JP3487617B2 - Cosmetics - Google Patents

Description

Description: BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to cosmetics having a high whitening effect and high safety. BACKGROUND OF THE INVENTION Cymbopogon nardus is a monocotyledonous plant net, a plant of the order of the order of the order of the Poaceae and of the genus Ogarukaya, which is used as a mosquito repellent, fragrance and soap. Used in medicine and antipyretic. [0003] Desmodiu Ganguechikum (Desmodiu)
m gangeticum) are dicots
It is a plant of the leguminous family and the genus Nervosa, and is used as a remedy for amenorrhea, abdominal pain, and so on. [0004] Cardiospermum halicaca
bum) is a divine cotyledon net, a petal flower subnet, a rodent order, a Scrophulariaceae, and a genus genus of the genus Oxodidae. It has been used as a therapeutic drug. [0005] Murraya koenigii
Is a species of dicotyledonous plant, leafy flower subassembly, pterosaur, and citrus, distributed in India and Sri Lanka and commonly found in dry lowlands. It has been used as a medicament for constipation, stomach colic, diarrhea, etc. [0006] Smilax zeyla
nica) was used as a remedy for sexually transmitted diseases, dysentery, and rheumatism in monocotyledonous nets, lilies, lilies, and genus plants. On the other hand, various substances having a whitening effect that can be used as a raw material of cosmetics are known.
Synthetic products are not guaranteed for long-term application to human skin, and their use is being restricted. On the other hand, many natural products have a weak whitening effect. However, it is a natural product that is safe for human skin, eaten by humans for many years, is guaranteed in terms of safety, has a strong whitening effect, and has other effects on skin. Was desired. [0008] An object of the present invention is to provide a cosmetic which is safe when applied to the skin, has a large whitening effect, and is excellent in safety. Means for Solving the Problems In order to solve the above-mentioned problems, the present inventors have screened and examined plants which have been edible for many years and whose safety to the human body has been confirmed. We examined what is useful as cosmetics. As a result, Kosuigaya, Desmodium
Gangechikum, Hydrangea, Muraya Koenigi,
Sumilux Zeilonica is a very cosmetic ingredient,
Alternatively, it has been found that it has an effect as a quasi-drug. [0010] That is, the present invention provides a beam Raya Koenigii (Murraya koenigii), Sumi Lux Zeiranika (Sm
ilax zeylanica) at least one selected from the group consisting of
A cosmetic comprising a solvent extract of the species. As a method for utilizing these plants, extraction is performed with water or a hydrophilic organic solvent such as ethanol, methanol, acetone or the like. However, it is a matter of course that extraction with water, ethanol or a mixed solvent thereof is preferable because it is the extraction of cosmetic raw materials. In some cases, a polyhydric alcohol such as glycerin, 1,3-butylene glycol, propylene glycol, or a mixture of polyhydric alcohol and water can also be used for extraction. It is also effective to freeze-dry and use it as a powder depending on the method of use. This substance is used as a raw material for other cosmetics such as liquid oils such as squalane and jojoba oil, solid oils such as beeswax and cetyl alcohol, various activators, humectants such as glycerin and 1,3 butylene glycol and various chemicals. It can be added to prepare various forms of cosmetics. For example, a use form may be considered depending on the purpose, such as a lotion, a cream, a milky lotion, and a pack. An embodiment which is an actual use method will be described below, but the present invention is not limited by this embodiment. The production examples of the extracts of Kosui-gaya, Desmodium ganguechikum, Fusenkazura, Muraya koenigi and Sumilux zeiranica used in the present invention are shown below. Production Example 1 300 g of 50% ethanol was added to 10 g of Rhizoma rhizome (dried product) and left for 5 days with occasional stirring. This was filtered and freeze-dried. (Production Example 2) 10 ml of whole plant (dried product) of desmodium ganguechikum was added with 300 ml of ethanol, and left for 5 days with occasional stirring. This was filtered and freeze-dried. (Production Example 3) 300 ml of a 50% aqueous ethanol solution was added to 10 g of the whole plant (dried product) of desmodium ganguechikum, and the mixture was allowed to stand for 5 days with occasional stirring. This was filtered and freeze-dried. (Production Example 4) 300 g of a 50% aqueous ethanol solution was added to 10 g of the whole plant (dried product) of Acacia catechu and left for 5 days with occasional stirring. This was filtered and freeze-dried. (Production Example 5) 300 ml of ethanol was added to 10 g of a branch (dry product) of Muraya koenigi and left for 5 days with occasional stirring. This was filtered and freeze-dried. (Production Example 6) 300 ml of a 50% aqueous ethanol solution was added to 10 g of Muraya koenigi branch (dry product), and the mixture was allowed to stand for 5 days with occasional stirring. This was filtered and freeze-dried. (Production Example 7) 300 ml of ethanol was added to 10 g of the roots (dry product) of Sumilux Zeiranica, and the mixture was left for 5 days with occasional stirring. This was filtered and freeze-dried. (Production Example 8) A 50% aqueous ethanol solution was added to 10 g of Sumilux Zeiranica root (dry product).
ml was added and left for 5 days with occasional stirring. This was filtered and freeze-dried. ( Reference Example 1) Lotion (% by weight) Olive oil 0.5 Extract of Production Example 1 0.5 Polyoxyethylene (20E.O.) Sorbitan monostearate 2.0 Polyoxyethylene (60E.O. ) Hardened castor oil 2.0 Ethanol 10.0 1.0% aqueous solution of sodium hyaluronate 5.0 Purified water 80.0 Reference Example 2 Cream (% by weight) A Squalane 20.0 Olive oil 2.0 Mink Oil 1.0 Jojoba oil 5.0 Beeswax 5.0 Cetostearyl alcohol 2.0 Glycerin monostearate 1.0 Sorbitan monostearate 2.0 Extract of Production Example 2 1.0 B Purified water 47.9 Polyoxy Ethylene (20E.O.) Sorbitan monostearate 2.0 Polyoxyethylene (60E.O.) hydrogenated castor oil 1.0 Glycerin 5.0 1.0% Hyaluronic Aqueous sodium 5.0 methyl parahydroxybenzoate 0.1 A and B were each weighed, warmed to 70 ° C., then it was added slowly with stirring A to B, while slowly stirring 30
Cooled to ° C. ( Reference Example 3) Reference lotion prepared by changing the extract of Production Example 1 of Example 1 to the extract of Production Example 3. ( Reference Example 4) A cream prepared by changing the extract of Production Example 2 of Reference Example 2 to the extract of Production Example 4. (Example 1 ) Reference lotion prepared by changing the extract of Production Example 1 of Example 1 to the extract of Production Example 5. [0027] (Example 2) cream that was created to change the extract of Preparation Example 2 of Reference Example 2 to the extract of Preparation Example 6. (Example 3 ) Reference lotion prepared by changing the extract of Production Example 1 of Example 1 to the extract of Production Example 7. Example 4 A cream prepared by changing the extract of Production Example 2 of Reference Example 2 to the extract of Production Example 8. (Tyrosinase activity inhibition test) (Test method) Mcllvaln buffer 0.9
ml, 1.66 mM Tyrosine (1.0 ml) solution, 0.1 wt / v% aqueous solution of the above-mentioned production example (lyophilized product) (If it is difficult to dissolve, add ethanol and dissolve, then add purified water, and evaporate. Then, ethanol was removed, and the mixture was adjusted to 0.1 wt / v% (1.0 ml) in a screw vial and heated in a constant temperature water bath at 37 ° C for 5 minutes or more. 0.1 ml of a tyrosinase solution (manufactured by Sigma, from mushrooms, 914 units / ml) was added, and 3
The temperature was kept in a constant temperature water bath at 7 ° C., and the absorbance was measured at 475 nm after 10 minutes. As a control, pure water was added instead of the sample solution, and the measurement was performed in the same manner. In this test, the final concentration of the sample was 0.1.
033%. (Calculation formula) Tyrosinase activity inhibition rate (%) = {B- (AP)} /
B × 100 where A: Absorbance of sample specimen B: Absorbance of control P: Absorbance due to coloring of sample specimen (3-fold dilution) The results are shown in Table 1. [Table 1] (Usage Test) The face of each of the five women was divided into left and right faces, one of which was applied with the lotion and cream of the example set, and the other was set with the lotion and cream of the comparative example. I got it. Comparative Example 1 is a lotion obtained by changing the extract of Production Example 1 of Reference Example 1 to water, and Comparative Example 2 is a cream obtained by changing the extract of Production Example 2 of Reference Example 2 to water. Every day, 1
They were used more than once, and after 3 months, they were given a score according to the following criteria. In addition, 20 persons were divided into four groups, and experiments were performed using the following samples. [Table 2] The criteria are as follows, and the total value of the scores is shown in Table 3. Example is very good 3 Example is considerably better 2 Example is slightly better 1 No difference 0 Comparative example is slightly better -1 Comparative example is much better -2 Comparative example It is much better -3 [Table 3] As is clear from the results of the tyrosinase activity inhibition test, the plant solvent extract of the present invention has an excellent tyrosinase activity inhibition effect. From the results of the use test, a remarkable whitening effect was recognized as compared with the cosmetics containing no cosmetics containing this extract. These plants have been used as internal and external medicines for many years, and their long-term safety to the human body is guaranteed.

──────────────────────────────────────────────────続 き Continuation of the front page (72) Inventor Kenji Shimomura 3-16-32 Funae, Ise-shi, Mie (72) Inventor Kayo Nakatani 774-11, Takano, Misonomura, Bakuai-gun, Mie (56) Reference Patent 3268695 (JP, B2) (58) Fields investigated (Int. Cl. ⁷ , DB name) A61K ^7/ 00-7/50 A61K 35/78

Claims (1)

(57) Claims: 1. A beam Raya Koenigii (Murraya Koenigi
i), Smilax zeylanica
A cosmetic comprising at least one solvent extract selected from the group consisting of: