JP3492954B2 - Skin discoloration agent - Google Patents

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a skin discoloring agent useful as an oral cosmetic composition. The skin discoloring agent is capable of easily, safely, and actively changing the skin to brown as a healthy color by ingesting orally.

[0002]

2. Description of the Related Art As a recent trend, sunburn is considered a symbol of good health. This is because people who are active in the field are more likely to get sunburn and their skin turns brown when exposed to the sun, which is one of the health promotion methods. Therefore, as one fashion, an increasing number of people are striving to have their skin brown and exposed to direct sunlight or irradiated with artificial ultraviolet rays.
Also, cosmetics applied to the skin to adjust the color tone,
Widely sold.

However, in the case of direct exposure to natural sunlight or artificial irradiation of the skin with ultraviolet rays or the like, the irradiation is likely to be passive. Therefore, it is difficult to adjust the color tone, and it is often impossible to obtain a desired brown color. In particular, in the case of a person whose skin color is relatively white, even if he / she wants to get a sunburn, his / her skin often turns red and cannot reach brown. In addition, a sunburn portion, a sunburn portion, or a sunburn-inhibited portion is generated, and the skin color has a shade.

Furthermore, if the skin is irradiated with too much radiation, the skin becomes inflamed, and it is accompanied by tingling pain, and after a few days, the skin is mottled and unsightly. Furthermore, not only these inconveniences, but too much exposure to ultraviolet rays, stains,
It is a well known fact that freckles can cause skin cancer in severe cases. At the same time, it is difficult for a busy person to appropriately continue to receive sunlight or artificially irradiate ultraviolet rays or the like.

Therefore, there has been a demand for a technique capable of easily and safely adjusting the skin to a brown color as a healthy color and maintaining it.

[0006]

DISCLOSURE OF THE INVENTION The present invention overcomes the above-mentioned problems in the conventional method, and easily and safely changes the color of the skin of the entire body including the face, and actively, brown as a health color. It is a technical subject to provide a skin discoloring agent as a cosmetic that changes into

[0007]

Means for Solving the Problems The present inventor, who has migrated from Japan to Brazil in South America, has focused on the use of carotenoid pigments obtained from the seeds of Bixa orellana for the purpose of solving the above problems. . In other words, it is said that, in the old days, Amazonian indians wondered that white feathered birds might turn reddish-brown in nature, and after careful observation, they discovered that they eat seeds of the alder tree. It is also said that when Europeans went on an Amazon expedition and lived with the Indios, they ate their food together and turned their bodies reddish brown. It is a fact that the present inventor himself also participated in a joint work 12 years ago in order to strengthen the color of chicken meat at a poultry farm, to finely grind the seeds of the alder tree and add them to the feed.

[0008] Based on such knowledge and experience, the present inventor has found that when the extract of soybean cypress seeds is taken, the skin color changes. Based on this recognition, as a result of further research, we found that oral administration of norbixin, a kind of carotenoid pigment obtained from the seeds of Rhododendron japonica, caused the skin to turn brownish.
In particular, it has an advantage that a desired color tone can be obtained by appropriately adjusting the dose and the period of administration, and that the color of the skin can be easily returned to the original color by stopping the administration. . The present invention has been completed based on these findings.

[0009] That is, the gist of the present invention is an oral skin discoloring agent characterized by containing norbixin as an essential component. By taking this skin discoloring agent orally, it is possible for the recipient to have a brownish color tone (e.g., light wheat color, light yellow reddish brown, light brown and yellow brown) that is like a healthy tan. Give skin.

Norbixin is the main pigment component of water-soluble atners that has hitherto been marketed as an edible pigment. That is, the water-soluble annatto is a reddish-brown to brown liquid, lump, powder or paste-like substance obtained by hydrolyzing the red coating of Rhododendron seeds, and its main pigment component is an alkali salt of norbixin. (Eg potassium or sodium salts). The content of norbixin is usually about 1% by weight when the water-soluble annatto is in a liquid state and 1 when it is in a powder state.
It is around 0% by weight (sometimes more). As food dye, water-soluble Anato is used as it is,
For example, as a cheese color, it is used for coloring cheese, butter, ice cream, etc., and for coloring the surface of a wiener sausage because of its particularly excellent dyeing power. Recently, it has been proposed to use it as a safe toner for electrophotography because it does not affect the human body even if it is absorbed into the body and has excellent coloring power (Japanese Patent Laid-Open No. Hei 5 (1999)).
-216278).

As described above, the water-soluble annatto is originally used as a pigment for food additives and has a high degree of safety, and the Japanese Food Additive Standards also stipulates that acute toxicity, subacute toxicity, and chronic toxicity. It is reported that no abnormalities or disorders were confirmed in any of the tests for specific toxicity and specific toxicity.

The skin discoloring agent of the present invention may be norbixin alone, which is an essential component thereof, but it is usually prepared in an appropriate dosage form together with an acceptable carrier so that it can be easily taken orally. The use of water-soluble annatto itself is not preferable because a large amount must be taken to achieve the desired discoloration, in which case side effects such as diarrhea and vomiting may be observed. Therefore, norbixin used as an essential component of the skin discoloration agent of the present invention is a substantially pure product.
Norbixin purified to the extent that it is recognized as (about 95 to 98%). Norbixin may be an alkali salt, but normally free norbixin is preferably used.

The skin discoloration agent of the present invention can be prepared into various dosage forms suitable for oral administration such as powders, granules, tablets, capsules and syrups. The carrier used in the preparation of these, water, vegetable oil, talc, lactose,
Various substances suitable for oral administration such as sucrose and corn starch can be mentioned, and as needed, various additives such as ascorbic acid, citric acid, tartaric acid, vitamins, yeast extract and the like can be added. . For example, when preparing a capsule, norbixin may be filled into a hard capsule alone or with a solid carrier such as talc or lactose, or norbixin may be filled into a soft capsule together with a liquid carrier such as a vegetable oil such as olive oil or sunflower oil. . The norbixin content per unit dose is 40% by weight or more.

The skin color-changing agent of the present invention is, in view of its use,
You may take the right amount at the right time, but usually, the oral dose is usually taken daily. By adjusting the dose appropriately, the skin of the whole body including the face can be easily, safely, and actively desired to have a light yellow reddish brown, a yellowish brown or a light wheat color, a light brown to dark brown color. You can change the color of. If you stop taking it, it will easily fade and
Within a few days you will be able to return to your original skin color.

Generally speaking, in an adult with a body weight of 50 to 70 kg, norbixin 50 to 800 mg per dose
Oral administration of (particularly 100-500 mg) three times daily in the morning, daytime, and evening, will cause a change in blood color on the face and limbs within 5 to 10 days, resulting in about 3
Within a week it changes to the desired healthy pale tan or tan, pale wheat or pale tan. At this point, if the dose is reduced to about half and the administration is continued in the same manner, the healthy color is maintained. If you stop taking the drug, 5 to 1
You can return to the original skin in about 0 days.

As a standard example, for an adult female (Oriental) weighing 50 kg, generally, 2 or 3 capsules each containing 300 mg of norbixin (free) per capsule, Oral administration is continued three times daily in the morning and afternoon. After 5 to 7 days, a change in blood color will be observed on the face and limbs, and a healthy wheat color will appear for about 15 to 20 days. When the desired color is reached, the dose can be reduced to about half, and if the dose is continued, the color can be maintained. In addition, if necessary, the dose can be appropriately adjusted to change and maintain a desired healthy color.

The relationship between the dose of the skin discoloring agent of the present invention and the degree of discoloration caused by it varies greatly among individuals, such as race, age, sex and weight. In any case, the desired health color is
The specific dose of the skin discoloring agent of the present invention may be appropriately determined by the individual taking the above-mentioned general description and the description of the standard example, because it depends on the individual preference. In this respect, the active ingredient norbixin is an extremely safe substance, and at least in the range of the usual amount used as the skin discoloring agent according to the present invention, it does not exert any harmful effects. I can say.

[0018]

EXAMPLES Examples will be shown below to enhance the understanding of the present invention, but the technical scope of the present invention should not be construed as being limited to these examples.

Example 1 (Preparation of pure norbixin) 2 L of 0.25N sodium hydroxide solution was added to 3 L at room temperature.
Soak 00 g of alder seeds without crushing.
Stir for about 20 minutes, and stop when the seed surface becomes blackish brown. Then filter through a gauze-like cloth,
Separate the seed part and norbixin solution. Then transfer the norbixin solution to another beaker and stir 0.2
Neutralize with 5N hydrochloric acid solution. Further, when a hydrochloric acid solution is added until the pH becomes 2, norbixin crystallizes. The obtained crystallized norbixin mixture is filtered through a filter paper for qualitative analysis, and the norbixin residue is dried in a dryer at 70 to 80 ° C. for about 5 to 8 hours until the water content becomes about 2%. The dried norbixin is crushed to give norbixin powder.
As a result, 21g of pure norbixin (about 95-98%)
Is obtained.

Example 2 (Preparation of skin discoloration agent) (1) Hard capsule preparation 200 mg to 500 mg of norbixin powder is mixed with 200 mg of lactose and filled into hard capsules. Alternatively, 200 mg to 500 mg of norbixin powder (pure product) is directly filled in a hard capsule. (2) Soft capsules Norbixin powder 200mg-500mg 100mg
Mix with ˜500 mg vegetable oil (eg olive oil, sunflower oil) and fill into soft capsules.

Example 3 (Dose Example) Subjects: 3 white women (25 years old, 23 years old, 20 years old), 2 Oriental people (25 years old, 23 years old). 2 capsules each at breakfast, lunch and dinner for subjects with no skin disease or allergies
(Containing 300 mg of norbixin per capsule) was taken. Oriental women had a change in the color of the face and limbs around the 5th day, and Caucasian women had a change in the color of the face and limbs around the 7th day. When the same amount was continued to be taken, both the white women and the Oriental women changed their whole body including the face into a tan or tan, and reached a peak around the 20th day. After that, the dosage was cut in half and continued to be taken, and the whole body kept a healthy color.

[0022]

INDUSTRIAL APPLICABILITY As described above, according to the present invention, by ingesting a small amount of a skin discoloring agent containing norbixin daily orally, the skin color of the whole body can be easily, safely, and actively obtained with a desired pale yellow color. It can be changed to reddish brown, yellowish brown or light brown or light brown.

Continuation of front page (51) Int.Cl. ⁷ Identification code FI A61P 17/00 A61P 17/00 (72) Inventor Kazuyuki Kawagoe Brazil, Sao Paulo, Sao Paulo, Peredices, Rua Santarem Numbero 242 (56) References JP-A-3-160946 (JP, A) JP-A-2000-63249 (JP, A) JP-A-11-209642 (JP, A) JP-A-8-231351 (JP, A) JP-A-2000-342219 (JP, A) Special table 2000-511923 (JP, A) (58) Fields surveyed (Int.Cl. ⁷ , DB name) A61K ⁷ /00-7/50 A61K 9/48 A61K 31/194 WPI (DIALOG )

Claims (4)

(57) [Claims] 1. An oral skin discoloring agent containing norbixin as an essential component. 2. At least 40% by weight per unit dose
The skin discoloring agent according to claim 1, which comprises the norbixin. 3. The skin discoloring agent according to claim 1, which contains norbixin together with an acceptable carrier. 4. The skin discoloring agent according to claim 1, which is prepared as a capsule.