JP3510751B2 - Whitening cosmetics - Google Patents

Description

Description: BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention is excellent in skin safety, has an effect of preventing skin inflammation due to ultraviolet rays, and has an effect of rapidly lightening darkened skin. Related to whitening cosmetics. More specifically, the present invention relates to a whitening cosmetic having a synergistically enhanced whitening effect by using nicotinamide and an oil-soluble licorice extract in combination, and having an effect superior to that of conventional cosmetics by containing them. [0002] Ultraviolet rays cause inflammation (erythema) of the skin and release various factors to stimulate melanocytes. As a result, the color tone changes and blackens. This darkening is due to overproduction of melanin, which is produced in melanocytes and passed to epidermal cells, and is produced by oxidation of tyrosine. Conventionally, vitamin C salts and fatty acid derivatives that prevent the oxidation of tyrosine, hydroquinone monobenzyl ether, hydrogen peroxide, A whitening cosmetic containing kojic acid or the like has been proposed. [0004] However, when kojic acid is added to these whitening cosmetics, the effect of suppressing inflammation and whitening by ultraviolet rays is not sufficiently exhibited. On the other hand, when hydroquinone monobenzyl ether or the like is blended in a whitening cosmetic, it has the effect of lightening dark-skinned skin, but has disadvantages such as a problem in skin safety. As described above, it is extremely difficult to obtain a whitening cosmetic having an excellent inflammation inhibitory effect, a whitening effect, high skin safety, and excellent storage stability. [0005] In view of such circumstances, the present inventors,
As a result of intensive studies to improve the difficulties of the prior art, when the oil-soluble licorice extract is blended alone, the anti-inflammatory, antibacterial, antioxidant, anti-tumour, antiplasmin, and melanin production inhibitory effects Was confirmed to have complex biological activity not found in other raw materials. However, the feeling of use when blended in the preparation was not sufficiently satisfied. [0006] Therefore, as a result of continuing research to further improve the complex physiological activity not found in other raw materials of the oil-soluble licorice extract, the whitening effect is synergistically enhanced when nicotinamide is used in combination. Was found. [0007] That is, the present invention, by using nicotinamide in combination with an oil-soluble licorice extract, has excellent ultraviolet absorbing effect, inflammation suppressing effect, whitening effect, high skin safety, and excellent feeling in use. The purpose is to provide whitening cosmetics. Means for Solving the Problems In order to achieve the above object, the present inventors have achieved excellent whitening effect by using nicotinamide in combination with an oil-soluble licorice extract while utilizing the characteristics of the oil-soluble licorice extract. The present inventors have found that a whitening cosmetic composition having high skin safety and excellent feeling in use can be obtained, and further, the inflammation-suppressing effect is further improved by a synergistic effect, and the present invention has been completed. Embodiments of the present invention will be described below in detail. [0010] Nicotinamide (a) used in the present invention is a known drug and is listed in the 13th revised edition of "Japan Pharmacopoeia". Its properties are white crystals or crystalline powder, no odor, and bitter taste. The molecular weight is 122.
13, easily soluble in water or ethanol, and hardly soluble in ether. It was used as a drug for peripheral circulatory disorders in the prevention and treatment of pellagra (which manifests symptoms such as nicotinic acid deficiency syndrome, dermatitis, photosensitivity, diarrhea, and psychiatric disorders). In modern times, it has become a useless drug. In addition, this drug does not have a vasodilatory effect like many skin disease drugs. Under such circumstances, in the field of cosmetics, nicotinamide has been attracting attention as a member of the vitamin B group. For example, it can be used as a softening agent for the skin, a prophylactic and therapeutic agent for dermatitis to a lesser extent, and an antioxidant. The oil-soluble licorice extract (b) used in the present invention is an oil-soluble licorice extract containing components such as glabridine, and is a specific type of licorice, that is, Glycyrrhiza glaba Linn.
e var. (commonly known as Russia, Afghan, Turkey licorice), and it is unique that this species alone has complex biological activity not found in other raw materials (Japanese Unexamined Patent Publication No.
-109314). In addition, as an extraction solvent of this extract, there are benzene, ethyl ether, chloroform, methylene chloride, ethyl acetate, n-butyl acetate, isobutyl acetate, n-propyl acetate and the like of intermediate polarity. The licorice to be subjected to the extraction treatment is immersed in about 5 to 15 times the amount of the above solvent or heated under reflux (Japanese Patent Application Laid-Open No. 3-109314). The amount of the nicotinamide used in the present invention in the whitening cosmetic is 0.0% in the total amount of the cosmetic.
1 to 10% by weight (hereinafter, abbreviated as wt%). [0013] The amount of the oil-soluble licorice extract of whitening cosmetic preparation for use in the present invention, as the total amount of the cosmetic total amount, the evaporation residue terms, 0.001～1.0Wt% der
You . [0014] The whitening cosmetic of the present invention, tar based dyes in addition to the essential ingredients, preservatives such path Raven, fatty acid soap, anionic surfactants such as sodium cetyl sulfate,
Polyoxyethylene alkyl ether, polyoxyethylene fatty acid ester, polyoxyethylene polyhydric alcohol fatty acid ester, polyoxyethylene hydrogenated castor oil,
Nonionic surfactants such as polyhydric alcohol fatty acid esters and polyglycerin fatty acid esters, cationic surfactants such as tetraalkylammonium salts, betaine type,
Sulfobetaine, sulfoamino acid type amphoteric surfactants such as N- stearoyl -L- sodium glutamate, lecithins, natural-based surfactants such as lysophosphatidylcholine, antioxidants such as dibutylhydroxytoluene and the like, It can be appropriately compounded within a range that does not impair the purpose of the present invention. [0015] Examples of the dosage form of the whitening cosmetic of the present invention include creams, emulsions, lotions, packs and the like. For example, in the case of an emulsion or the like, these can be produced by a usual method of emulsifying and dispersing a solution obtained by heating and dissolving an oil phase and an aqueous phase, respectively, followed by cooling. Further, the whitening cosmetic of the present invention can also be applied as pharmaceuticals and quasi-drugs. The present invention will be described in detail below with reference to examples and comparative examples. The concentration of each component blended in Examples and Comparative Examples is% by weight (hereinafter simply referred to as%). The oil-soluble licorice extract used in the Examples is a powder obtained by removing the solvent, and has a glabridine content of 75%. (1) Skin lightness recovery test, (2) Whitening practical test, (3) UV erythema suppression test,
The test methods of (4) optical patch test and (5) sensory test are as follows. (1) Skin color lightness recovery test The upper arm inner skin of 20 subjects (in a 2 × 2 cm section, 2
Location)) and an ultraviolet irradiation device (Dermalei, N-DMR)
After irradiating the minimum erythema amount of UVB in the UVB region for 3 days using a mold, manufactured by Toshiba Medical Supplies), the standard lightness (V0 value, V0 'value) of the sample-applied part and the base-applied part skin is colored It was measured by a color difference meter (CR-221 type, manufactured by Minolta). Subsequently, a 5 mg / cm ² sample and a base were applied three times a day for 4 consecutive weeks, and the skin lightness (Vn value, V
n ′ value), and the skin color recovery was evaluated according to the criteria shown in Table 1. In addition, evaluation is shown by the average value of the evaluation point of 20 test subjects after 4 weeks. [Table 1] (2) Whitening Practical Test The skin on both sides of the forearm flexed by 20 subjects was exposed to sunlight in summer.
Time (1.5 hours a day for 2 days). The left forearm flexor skin had a sample from the day exposed to sunlight, and the right forearm flexor skin had a base 5 mg / cm ² from the day exposed to sunlight.
, And applied once in the morning and evening for 13 consecutive weeks. In addition, the evaluation is shown by the number of subjects for which the effect of the sample application section was more remarkably confirmed than that of the base application section. (3) UV erythema suppression test The back skin of 10 Hartley-type guinea pigs whose hair had been removed
Using the same ultraviolet irradiation apparatus as described above, twice the minimum erythema amount of ultraviolet light in the UVB region was irradiated to two places (within a 2 × 2 cm section). 24 hours before and immediately after irradiation, 5 mg / cm ²
Table 2 shows the erythema state 24 hours after the sample and the base were applied to the sample and the base.
The evaluation was performed in accordance with the evaluation criteria. [Table 2] (4) Optical Patch Test A closed patch test was performed for 24 hours using a 1.0 cm diameter aluminum plate for patch test on which 50 mg of a sample was applied to the skin of the flexed side of the forearm of 25 subjects. ,
It was exposed to summer sunlight for 6 hours (3 hours a day, 2 days). In the evaluation, 24 hours after irradiation, the skin condition of 25 subjects was evaluated and determined according to the criteria shown in Table 3. In addition,
The results are shown by the number of people (±) or more. [Table 3] (5) Sensory Test Using 20 test subjects, an appropriate amount of the sample was applied to the face, and the characteristics of the sample after continuous application for 10 days were evaluated. The evaluation is shown by the number of respondents who answered "moisture on the skin", "good affinity for the skin", and "improved the gloss of the skin" for the questionnaire items such as wettability and affinity. Examples 1-4, Comparative Examples 1-3 (Skin Lotion) Skin lotions were prepared by mixing the active ingredients in the raw material composition shown in Table 4 as shown in Table 5, and the above tests were carried out. Carried out. [Table 4] [Table 5] (1) Preparation method After dissolving the B component and the C component uniformly in the D component and the A component in Table 4, the A component and the D component are uniformly mixed and stirred, and then filled in a container. And made it into a product. (2) The results of the various properties tests are also shown in Table 5. As shown in Table 5, Comparative Examples 1 to 3 did not show good results in various tests. On the other hand, the whitening cosmetics of the present invention of Examples 1 to 4 showed clearly good results in all tests. Further, in various tests using human skin, no skin irritation was observed during the test period and at the end of the test. Examples 5 to 8 and Comparative Examples 4 to 6 (skin cream) Skin creams were prepared by mixing the active ingredients as shown in Table 7 with the raw material compositions shown in Table 6, and the above tests were carried out. Carried out. [Table 6] [Table 7] (1) Preparation method The component C shown in Table 6 was mixed with the component A, and the component B was mixed with the component D, and each was heated and dissolved uniformly to reach a temperature of 80 ° C. Next, after injecting and emulsifying the D component in the A component, the mixture was cooled to 30 ° C. with stirring, and then filled into a container to obtain a product. (2) The results of the various properties tests are also shown in Table 7. As shown in Table 7, Comparative Examples 4 to 6 did not show good results in various tests. On the other hand, Examples 5 to 8 showed clearly good results in all of the tests. In addition, no skin irritation occurred in various tests on human skin. As described above, the present invention is excellent in an ultraviolet ray absorbing effect, is excellent in a skin inflammation suppressing effect by ultraviolet rays,
It is apparent that the present invention provides a whitening cosmetic having a rapid effect of lightening skin pigmentation and a useful feeling without skin irritation.

Claims (1)

(57) [Claims] (1) (a) 0.01 to 10 nicotinamide
A whitening cosmetic comprising: (b) an oil-soluble licorice extract in an amount of 0.001 to 1.0% by weight in terms of an evaporation residue. (However, it does not contain urea, ultraviolet absorbers, and ultraviolet scattering agents.)