JP3517318B2

JP3517318B2 - Rafu-macha with cholesterol lowering action

Info

Publication number: JP3517318B2
Application number: JP06541496A
Authority: JP
Inventors: 恒雄難波; 征雄服部; 隆子横澤; 重利門田
Original assignee: Toyama Chemical Co Ltd
Current assignee: Toyama Chemical Co Ltd
Priority date: 1996-02-27
Filing date: 1996-02-27
Publication date: 2004-04-12
Anticipated expiration: 2016-02-27
Also published as: JPH09224623A

Description

【発明の詳細な説明】【０００１】【産業上の利用分野】本発明は、コレステロール低下作
用を有する羅布麻の葉をばい煎したお茶（以下、羅布麻
茶という。）に関する。【０００２】【従来の技術】羅布麻（学名：Apocynum venetum L.）
は、中国に広く分布しているキョウチクトウ科の多年生
宿草本（草本とは、俗に”草”と呼ばれているもの）植
物である。中国では、古来より羅布麻の葉をお茶の葉の
代わりとして利用しており、また、その羅布麻茶は、解
熱などの民間薬としても利用されている。さらに、中国
の複数の研究機関が民間薬として利用されている羅布麻
葉について医学的および薬学的に研究を重ねており、そ
の結果、高血圧、心不全、気管支炎、水腫等に有効であ
ることが報告されている。一方、日本においても羅布麻
茶は、例えば、商品名：燕龍茶として市販されており、
いろいろな作用を持つお茶として注目されている。【０００３】【発明が解決しようとする課題】高コレステロール血症
の治療には、種々の医薬が使用されているが、お茶の１
種である羅布麻茶が高コレステロール血症に対して、特
に、LDL-コレステロール値を低下させると同時に、HDL-
コレステロール値を上昇させ、動脈硬化の指標である動
脈硬化指数を低下させることは知られていない。【０００４】【課題を解決するための手段】本発明者等は、羅布麻葉
の循環器系に及ぼす効果に着目し、高コレステロール血
症に及ぼす効果を検討した結果、羅布麻茶が、コレステ
ロール低下作用を有することを見出し、本発明を完成す
るに至った。また、羅布麻葉は、お茶以外に、エキス、
粉末等の形態で食品に利用することができる。【０００５】【実施例】つぎに、本発明の羅布麻茶のコレステロール
低下作用について述べる。［サンプル］以下の羅布麻抽出物を使用した。・Rafuma １：茶葉^*12.7kgの水抽出物583g（21.59％）・Rafuma ２：茶葉^*21.3kgの水抽出物326g（25.08％）・Rafuma ３：茶葉^*3545.5gの水抽出物115g（21.06％）・Rafuma ４：茶葉^*41.3kgの水抽出物231g（17.76％）^*1 茶葉は、中国産羅布麻を天日乾燥したものを使用し
た。^*2 茶葉は、中国産羅布麻を一回ばい煎したものを使用
した。^*3 茶葉は、中国産羅布麻を加熱乾燥したものを使用し
た。^*4 茶葉は、中国産羅布麻を二回ばい煎したもの（商品
名：燕龍茶）を使用した。羅布麻抽出物は、それぞれ加熱抽出し凍結乾燥して得
た。［実験群］・Ｉ群：標準食（正常食）・II群：高コレステロール食（対照群）・III群：高コレステロール食＋Rafuma １・IV群：高コレステロール食＋Rafuma ２・Ｖ群：高コレステロール食＋Rafuma ３・VI群：高コレステロール食＋Rafuma ４【０００６】１群８匹のWistar系雄性ラット（６週令、
体重約170g）に、高コレステロール食｛粉末飼料（CE-
2、日本クレア製）にコレステロール１％、コール酸0.5
％を添加したもの｝を自由に与え、pair feeding sched
uleで飼育する。羅布麻抽出物を実験開始〜20日までは3
5mg／匹、21〜40日までは70mg／匹を連日投与し、投与
開始日より10日、20日、30日目に尾静脈から採血して、
遠心分離（3000rpm、15min）後、血清を分離し、総コレ
ステロールを測定した。また、実験終了40日目にはラッ
トを断頭により屠殺して、血清、肝組織を得、各種コレ
ステロールを比色法、Noma法でそれぞれ定量した。実験
結果は平均値±標準誤差で表示し、各群間の有意差検定
はFisherのProtected LSD（Least Significant Differe
nce）を用いた。結果を表１〜表７に示す。【０００７】【表１】［羅布麻茶のラット体重に対する効果］（単位：g） −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−− 群投与日数０ 10 20 30 40 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−− Ｉ 204.0±1.7 261.7±3.6 303.0±3.5 326.6±4.9 345.0±5.7 II 199.4±2.4 247.1±3.1 290.9±5.4 322.6±5.0 346.5±5.1 III 200.1±1.2 255.1±2.4 290.1±2.8 321.3±4.5 347.0±5.7 IV 200.5±2.8 252.5±3.1 287.0±3.8 315.6±5.4 338.9±7.6 Ｖ 200.5±3.2 257.1±4.9 283.9±5.5 318.8±7.0 350.8±8.1 VI 202.1±1.5 253.6±3.6 279.1±4.5 311.3±6.5 316.0±5.7^a −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−− 有意差：^ap<0.05対コレステロール食対照群値【０００８】【表２】［体重、食餌摂取量、肝重量］ −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−− 群体重(g) 食餌摂取量肝重量投与前投与後増加 (g/匹/日) (g/100g体重) −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−− Ｉ 204.0±1.7 345.0±5.7 141.0±4.5 21.37 3.28±0.08 II 199.4±2.4 346.5±5.1 147.1±4.4 21.38 3.69±0.14 III 200.1±1.2 347.0±5.7 146.9±5.4 21.18 3.53±0.15 IV 200.5±2.8 338.9±7.6 138.4±8.0 21.40 3.67±0.12 Ｖ 200.5±3.2 350.0±8.1 150.3±5.8 21.18 3.85±0.15 VI 202.1±1.5 316.0±5.7^a 113.9±5.4^b 20.44 3.48±0.12 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−− 有意差：^ap<0.05, ^bp<0.01対コレステロール食対照群値【０００９】【表３】［羅布麻茶の血清総コレステロール値に対する効果］（単位：mg／dl） −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−− 群投与日数 10 20 30 40 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−− Ｉ 73.8±3.2 63.8±1.3 70.8±2.2 58.7±2.8 II 126.2±9.8 123.2±6.3 125.2±3.1 117.7±6.1 III 118.2±5.3 122.0±7.6 117.2±5.1 103.4±5.6 IV 116.9±8.6 115.1±6.9 100.9±6.0 98.7±5.0 Ｖ 127.2±7.7 128.1±6.2 119.1±7.7 113.6±4.7 VI 116.8±6.2 119.9±6.9 109.6±3.4 95.9±5.4 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−− 【００１０】【表４】［40日目における羅布麻茶の血清成分に対する効果（１）］ −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−− 群総コレステロール遊離コレステロールエステル化コレステロールエステル比 (mg／dl) (mg／dl) (mg／dl) −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−− Ｉ 58.7±2.8 6.82±0.55 51.84±2.90 88.17±1.17 II 117.7±6.1 20.67±2.09 94.10±4.45 82.16±0.96 III 103.4±5.6 17.16±1.03 87.18±4.41 84.40±0.53 IV 98.7±5.0^a 16.25±1.11^a 82.42±4.04 83.43±0.49 Ｖ 113.6±4.7 19.81±1.27 91.68±3.94 82.28±0.69 VI 95.9±5.4^b 14.16±1.41^b 85.58±5.27 84.74±0.88^a −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−エステル比＝（総コレステロール−遊離コレステロール／総コレステロール）×100 有意差：^ap<0.05, ^bp<0.01対コレステロール食対照群値【００１１】【表５】［40日目における羅布麻茶の血清成分に対する効果（２）］ −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−− 群総コレステロール LDL-コレステロール HDL-コレステロール動脈硬化指数 (mg／dl) (mg／dl) (mg／dl) −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−− Ｉ 58.7±2.8 11.08±0.72 34.02±1.57 0.74±0.10 II 117.7±6.1 52.46±3.89 26.19±1.48 3.43±0.21 III 103.4±5.6 44.12±2.95^c 30.78±2.11 2.40±0.13^c IV 98.7±5.0^a 40.69±3.59^c 30.92±1.66^a 2.03±0.10^c Ｖ 113.6±4.7 48.93±4.17^c 32.40±1.60^a 2.52±0.19^c VI 95.9±5.4^b 42.17±6.02^c 32.27±2.34^a 2.08±0.28^c −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−− 動脈硬化指数：(総コレステロール−HDL-コレステロール)／HDL-コレステロール有意差：^ap<0.05, ^bp<0.01, ^cp<0.001対コレステロール食対照群値【００１２】【表６】［羅布麻茶の肝総コレステロール値に対する効果］ −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−− 群総コレステロール mg／g肝 mg／肝 mg／肝／100g体重 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−− Ｉ 5.96±0.37 67.3± 4.1 19.5±1.0 II 28.35±1.48 385.7±27.3 110.2±6.7 III 23.27±0.93 259.8±11.9 78.8±4.2 IV 21.15±1.00 283.7±12.8 83.9±4.0 Ｖ 22.23±0.64 295.9±13.5 84.7±3.7 VI 19.42±1.25 226.6± 9.5 67.4±4.4 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−− 【００１３】【表７】［羅布麻茶の全血中における総コレステロール量に対する効果］ −−−−−−−−−−−−−−−−−− 群総コレステロール(mg) −−−−−−−−−−−−−−−−−− Ｉ 15.55±0.75 II 30.59±1.67 III 27.73±1.82 IV 25.39±1.43^a Ｖ 30.55±1.18 VI 23.08±1.27^b −−−−−−−−−−−−−−−−−− 有意差：^ap<0.05, ^b<0.001対コレステロール食対照群値【００１４】表１および表２で、VI群において、食餌摂
取量は対照群と比較して有意差がないにもかかわらず、
体重の増加は対照群と比較して減少していることがわか
る。このことから、体重の減少は代謝回転の促進による
ものと考えられる。また、表３〜７では、IV群およびVI
群においては、血清総コレステロール、LDL-コレステロ
ールの低下、HDL-コレステロールの上昇および動脈硬化
指数の改善効果が、また、III群においては、LDL-コレ
ステロールの低下、Ｖ群においては、LDL-コレステロー
ルの低下、HDL-コレステロールの上昇および動脈硬化指
数の改善効果がみられる。よって、羅布麻茶には抗高コ
レステロール作用を有することが示された。【発明の効果】本発明に係る羅布麻茶は、高コレステロ
ール血症等の疾患に有効である。Description: BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to tea made by roasting rapeseed leaves having a cholesterol-lowering effect (hereinafter referred to as rapeseed tea). [0002] Rabo hemp (scientific name: Apocynum venetum L.)
Is a perennial inhabiting herbaceous plant of the Oleaceae family (commonly called "grass") that is widely distributed in China. In ancient China, Lufu hemp leaves have been used as a substitute for tea leaves since ancient times, and Rabo hemp tea has also been used as a folk medicine such as antipyretic. In addition, several research institutes in China have been conducting medical and pharmacological studies on Lufu Asaba, which is used as a folk medicine, and reported that it is effective for hypertension, heart failure, bronchitis, edema, etc. Have been. On the other hand, in Japan, Rafu-macha is commercially available, for example, under the trade name: Tsuryuucha.
It is attracting attention as a tea with various functions. [0003] Various medicaments have been used for the treatment of hypercholesterolemia.
Rabo-macha, a species that reduces cholesterol, especially LDL-cholesterol,
It is not known to raise cholesterol levels and lower the atherosclerosis index, an indicator of atherosclerosis. Means for Solving the Problems The present inventors have focused on the effect of Rafu-maha on the circulatory system and studied its effect on hypercholesterolemia. The present inventors have found that they have an effect, and have completed the present invention. In addition, Lufu Asaba is not only tea, but also extracts,
It can be used in foods in the form of a powder or the like. Next, the cholesterol lowering effect of Rabo-macha of the present invention will be described. [Sample] The following Rafu hemp extract was used.・ Rafuma 1: Tea leaf ^{* 1} 583g (21.59%) of 2.7 kg water extract ・ Rafuma 2: Tea leaf ^{* 2} 326 g (25.08%) 1.3 kg water extract ・ Rafuma 3: Tea leaf ^{* 3} 115 g of 545.5 g water extract (21.06%) ・ Rafuma 4: Tea leaves ^{* 4} 231 g (17.76%) of 1.3 kg of water extract ^{* 1 As for} tea leaves, sun-dried Chinese Lufu was used. ^{* 2 The} tea leaves used were roasted from Chinese Lufu once. ^{* 3} Tea leaves were made by heating and drying Chinese Lufu linen. ^{* 4 The} tea leaves used were roasted roasted Chinese bean twice (trade name: Yanlong tea). The Labo hemp extract was obtained by heating extraction and freeze-drying, respectively. [Experimental group] ・ Group I: standard diet (normal diet) ・ Group II: high cholesterol diet (control group) ・ Group III: high cholesterol diet + Rafuma 1 ・ Group IV: high cholesterol diet + Rafuma 2 ・ Group V: high cholesterol diet + Rafuma 3 · VI group: high cholesterol diet + Rafuma 4 [0006] Eight Wistar male rats (6 weeks old,
Weight about 170g), high cholesterol diet ｛powder feed (CE-
2, Clea Japan) 1% cholesterol, cholic acid 0.5
% Added freely, pair feeding sched
Keep in ule. From the start of the experiment on Rabo hemp extract to 3rd until 20th
5 mg / animal, 70 mg / animal was administered daily from 21 to 40 days, and blood was collected from the tail vein on days 10, 20, and 30 from the administration start date.
After centrifugation (3000 rpm, 15 min), serum was separated and total cholesterol was measured. On the 40th day after the experiment, the rats were sacrificed by decapitation, and serum and liver tissue were obtained. Various cholesterols were quantified by a colorimetric method and a Noma method, respectively. The experimental results are shown as the mean ± standard error, and the significance test between each group was performed using Fisher's Protected LSD (Least Significant Differe
nce) was used. The results are shown in Tables 1 to 7. [Effect of Rafu-ma-cha on body weight of rat] (Unit: g)-------------------------------------------------------------------------------- −−−−−−−− group Administration days 0 10 20 30 40 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−− −− I 204.0 ± 1.7 261.7 ± 3.6 303.0 ± 3.5 326.6 ± 4.9 345.0 ± 5.7 II 199.4 ± 2.4 247.1 ± 3.1 290.9 ± 5.4 322.6 ± 5.0 346.5 ± 5.1 III 200.1 ± 1.2 255.1 ± 2.4 290.1 ± 2.8 321.3 ± 4.5 347.0 ± 5.7 IV 200.5 ± 2.8 252.5 ± 3.1 287.0 ± 3.8 315.6 ± 5.4 338.9 ± 7.6 V 200.5 ± 3.2 257.1 ± 4.9 283.9 ± 5.5 318.8 ± 7.0 350.8 ± 8.1 VI 202.1 ± 1.5 253.6 ± 3.6 279.1 ± 4.5 311.3 ± 6.5 316.0 ± 5.7 ^a − −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−− Significant difference: ^a p <0.05 vs. cholesterol diet control group value [Table 2] [Body weight, dietary intake, liver weight] ---------------------- −−−−−−−−−−−−−−−−−−−− Group Body weight (g) Food intake Liver weight Before administration Increase after administration (g / animal / day) (g / 100g body weight) −− −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−− I 204.0 ± 1.7 345.0 ± 5.7 141.0 ± 4.5 21.37 3.28 ± 0.08 II 199.4 ± 2.4 346.5 ± 5.1 147.1 ± 4.4 21.38 3.69 ± 0.14 III 200.1 ± 1.2 347.0 ± 5.7 146.9 ± 5.4 21.18 3.53 ± 0.15 IV 200.5 ± 2.8 338.9 ± 7.6 138.4 ± 8.0 21.40 3.67 ± 0.12 V 200.5 ± 3.2 350.0 ± 8.1 150.3 ± 5.8 21.18 3.85 ± 0.15 VI 202.1 ± 1.5 316.0 ± 5.7 ^a 113.9 ± 5.4 ^b 20.44 3.48 ± 0.12 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−− ------ significant ^{^{difference: a p <0.05, b p}} <0.01 versus-cholesterol diet control group value [0009] [Table 3] [effects on serum total cholesterol value of Luo cloth hemp tea] (unit: mg / dl) −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−− − Group days of administration 10 20 30 40 −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−− I 73.8 ± 3.2 63.8 ± 1.3 70.8 ± 2.2 58.7 ± 2.8 II 126.2 ± 9.8 123.2 ± 6.3 125.2 ± 3.1 117.7 ± 6.1 III 118.2 ± 5.3 122.0 ± 7.6 117.2 ± 5.1 103.4 ± 5.6 IV 116.9 ± 8.6 115.1 ± 6.9 100.9 ± 6.0 98.7 ± 5.0 V 127.2 ± 7.7 128.1 ± 6.2 119.1 ± 7.7 113.6 ± 4.7 VI 116.8 ± 6.2 119.9 ± 6.9 109.6 ± 3.4 95.9 ± 5.4 −−−−−−−−−−−−−−−−−−−−−−−−−−−−− [Effect of Rabo-ma-cha on Serum Components on Day 40 (1)] --------------------------------------------------------------------------- −−−−−−−−−−−−−−−−− group Total cholesterol Free cholesterol esterified cholesterol ester ratio (mg / dl) (mg / dl) (mg / dl) −−−−−−− −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−− I 58.7 ± 2.8 6.82 ± 0.55 51.84 ± 2.90 88.17 ± 1.17 II 117.7 ± 6.1 20.67 ± 2.09 94.10 ± 4.45 82.16 ± 0.96 III 103.4 ± 5.6 17.16 ± 1.03 87.18 ± 4.41 84.40 ± 0.53 IV 98.7 ± 5.0 a 16.25 ± 1.11 a 82.42 ± 4.04 83.43 ± 0.49 V 113.6 ± 4.7 19.81 ± 1.27 91.68 ± 3.94 82.28 ± 0.69 VI 95.9 ± 5.4 ^b 14.16 ± 1.41 ^b 85.58 ± 5.27 84.74 ± 0.88 ^a −−−−−−−−−−−−−−−−−− ------------------- ester ratio = (total cholesterol - free cholesterol / total cholesterol) × 100 significant ^{^{differences: a p <0.05, b p}} <0.01 vs. cholesterol diet control Table 5 [Effect of Rafu-ma-cha on Serum Components on Day 40 (2)] --------------------------------------------------------------------------- −−−−−−−−−−−− group Total cholesterol LDL-cholesterol HDL-cholesterol Atherosclerosis index (mg / dl) (mg / dl) (mg / dl) −−−−−−−−−−−−− −−−−−− −−−−−−−−−−−−−−−−−−−− I 58.7 ± 2.8 11.08 ± 0.72 34.02 ± 1.57 0.74 ± 0.10 II 117.7 ± 6.1 52.46 ± 3.89 26.19 ± 1.48 3.43 ± 0.21 III 103.4 ± 5.6 44.12 ± 2.95 ^c 30.78 ± 2.11 2.40 ± 0.13 ^c IV 98.7 ± 5.0 ^a 40.69 ± 3.59 ^c 30.92 ± 1.66 ^a 2.03 ± 0.10 ^c V 113.6 ± 4.7 48.93 ± 4.17 ^c 32.40 ± 1.60 ^a 2.52 ± 0.19 ^c VI 95.9 ± 5.4 ^b 42.17 ± 6.02 ^c 32.27 ± 2.34 ^a 2.08 ± 0.28 ^c −−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−− Arteriosclerosis index: (total cholesterol -HDL- cholesterol) / HDL- cholesterol significant ^{^{difference: a p <0.05, b p}} <0.01, c p <0.001 vs. cholesterol diet control group value [0012] [Table 6] [liver total cholesterol of Luo cloth hemp tea Effect on Value] Group: Total cholesterol mg / g Liver mg / Liver:---------------------------- mg / liver / 100 g body weight -------- −−−−−−−−−−−−−−−−−−−−− I 5.96 ± 0.37 67.3 ± 4.1 19.5 ± 1.0 II 28.35 ± 1.48 385.7 ± 27.3 110.2 ± 6.7 III 23.27 ± 0.93 259.8 ± 11.9 78.8 ± 4.2 IV 21.15 ± 1.00 283.7 ± 12.8 83.9 ± 4.0 V 22.23 ± 0.64 295.9 ± 13.5 84.7 ± 3.7 VI 19.42 ± 1.25 226.6 ± 9.5 67.4 ± 4.4 −−−−−−−−−−−−−−−−−−−−− [Table 7] [Effect of Rafu-ma-cha on total cholesterol level in whole blood]-------------------------------------------------------------------------- −−−−−− group Total cholesterol (mg) −−−−−−−−−−−−−−−−−−− I 15.55 ± 0.75 II 30.59 ± 1.67 III 27.73 ± 1.82 IV 25.39 ± 1.43 ^a V 30.55 ± 1.18 VI 23.08 ± 1.27 ^b −−−−−−−−−−−−−−−−−− Significant difference: ^a p <0.05, ^b <0.001 vs. cholesterol diet control group values Tables 1 and 2 In group VI, food intake was significantly different from control group. In spite of the stomach,
It can be seen that the weight gain has decreased compared to the control group. This suggests that the weight loss is due to the promotion of turnover. In Tables 3 to 7, the groups IV and VI
In the group, serum total cholesterol, LDL-cholesterol lowering, HDL-cholesterol raising and atherosclerosis index improving effects were observed. In group III, LDL-cholesterol lowering was observed. Decreases, increases HDL-cholesterol and improves the atherosclerosis index. Therefore, it was shown that Rafu-macha has an anti-high cholesterol effect. The Rafu-macha according to the present invention is effective for diseases such as hypercholesterolemia.

───────────────────────────────────────────────────── フロントページの続き (56)参考文献特開平５−194464（ＪＰ，Ａ) ＮａｔｕｒａｌＭｅｄｉｃｉｎｅｓ，Ｖｏｌ．49，Ｎｏ．４（1995）, ｐ．475−477 (58)調査した分野(Int.Cl.⁷，ＤＢ名) A23L 2/00 - 2/38 A23L 1/30 A61K 35/78 ＪＳＴＰｌｕｓ（ＪＯＩＳ)──────────────────────────────────────────────────続き Continuation of front page (56) References JP-A-5-194464 (JP, A) Natural Medicines, Vol. 49, no. 4 (1995), p. 475-477 (58) Fields investigated (Int. Cl. ⁷ , DB name) A23L 2/00-2/38 A23L 1/30 A61K 35/78 JSTPlus (JOIS)

Claims

(57) [Claim 1] Rabo-mapa tea obtained from roasted Rafu-mapa leaves having an action of lowering LDL-cholesterol level and simultaneously raising an HDL-cholesterol level.