JP3523009B2 - Aqueous thickened gel composition and liquid oil-in-water emulsion composition - Google Patents

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to an aqueous thickening gel composition and a liquid oil-in-water emulsion composition, and more particularly to improving the composition of a thickening gelling agent.

[0002]

2. Description of the Related Art In the fields of pharmaceuticals, cosmetics and the like, various aqueous thickening gelling agents have been used for the purpose of gelation for retaining the dosage form or thickening for improving usability. For example, organic compounds include polysaccharides, natural polymers such as casein, chemically modified polysaccharides, synthetic polymers such as polyethylene glycol and acrylic acid polymers, and inorganic compounds include various types such as montmorillonite. Clay minerals, silica, etc. are appropriately used depending on the intended effect.

On the other hand, a liquid oil-in-water type emulsion composition, that is, an emulsion, is not only a water-based gel composition, but also a drug, a cosmetic, etc., in which an oil component is further mixed, that is, an emulsion is a feel, stability and rheology at the time of its use. Characteristics and the like become important problems, and it is desired that the material has good spreadability and stability during use. In order to prevent creaming of oil droplets, it is necessary for these emulsion compositions to thicken and gelate the external water phase by some method, and it is desirable that the water phase has high thixotropy. Has been. Therefore, under the present circumstances, various aqueous thickening gelling agents as described above are also blended in order to maintain the stability of the emulsion against creaming.

When such a thickening gelling agent is used as an external preparation for the skin, it is required not only to have a high level of safety for the skin and the like but also to have a good feeling in use. Further, in consideration of various usage situations, it is desirable to have good stability such as temporal stability and temperature stability. Furthermore, normal human skin is covered with a weakly acidic sebum coating, and the pH is constantly controlled to a normal weakly acidic level by the secretion of an acidic substance against external contact with an alkaline substance. Considering that the thickening gelling agent to be added to the external preparation for skin exists on the skin for a long time, it is desired to have a weak acidity as close as possible to the pH of normal human skin.

[0005]

However, a thickening gelling agent having all of these characteristics has not been known so far. For example, it is known that high-molecular-weight thickening gelling agents are relatively safe and some of them exhibit good thickening gelling ability even when added in a small amount. Produces a "slickness" peculiar to polymers, and gives an unfavorable feeling of use. Further, the clay mineral has a high thixotropic property and has a refreshing and pleasant feeling to use, but it is likely to cause syneresis and is unstable with time.

Further, a combination of a hydrophilic nonionic surfactant and an amphipathic substance, an ionic surfactant such as a higher fatty acid salt or a monoalkyl quaternary ammonium salt and an amphipathic substance forms a complex. , It is well known that the complex forms a network structure and gels in the aqueous phase. And, it is relatively easy to prepare a stable cream with a combination of a surfactant and an amphipathic substance known so far, but the liquid oil-in-water emulsion composition of the present invention, that is, the emulsion It is difficult to prepare. The reason is that when emulsions are prepared with these systems, stability (creaming) remains a problem, and the thickening gelling agent is inevitably used in large amounts. Even if a stable product can be obtained without using (a composition in combination with a cationic surfactant), these are not preferable in terms of safety as an external preparation for skin.

Recently, a gel having a thixotropic property is obtained by once heating an aqueous solution containing an N-long-chain acyl acidic amino acid salt and water in a weight ratio of 5/95 to 30/70 and then rapidly cooling it. It has been reported that a solid composition can be obtained (JP-A-6-57290), and since the monosalt of N-long-chain acyl acidic amino acid is weakly acidic, it is attracting attention as a weakly acidic thickening gelling base.

However, in recent years, it has been widely recognized that surfactants have some irritating effect on the skin, and it is desirable to reduce the amount of surfactants used as much as possible. ing. Although N-long-chain acyl acidic amino acid salt is a surfactant with relatively low irritation, there is no change in the desire to reduce the amount of surfactant used as much as possible, and it exhibits thickening gelation ability at lower concentrations. It was desired to do.

Further, when the amount of the N-long chain acyl acidic amino acid salt used is large, it is not possible to obtain a smooth feeling of use as a composition and a slimy feeling is produced. It was desired to reduce the amount. further,
The N-long chain acyl acidic amino acid salt alone has a low melting point of its hydrate, which may cause a problem in high temperature stability.
The present invention has been made in view of the above-mentioned problems of the prior art, and its purpose is stability over time, safety, excellent usability, and a weakly acidic aqueous thickening gel having a good thickening gelation ability in water. The object of the present invention is to provide a liquid composition and a liquid oil-in-water emulsion composition thickened thereby.

[0010]

Means for Solving the Problems As a result of intensive studies to achieve the above-mentioned object, the present inventors have found that an N-long-chain acyl acidic amino acid monosalt and an amphipathic substance are associated with each other in water. The present invention has been completed by finding out that it is formed, and that it exhibits an excellent thickening gelling ability.

That is, the aqueous thickened gel-like composition according to the present invention comprises (A) an N- containing long-chain acyl group having 16 or more carbon atoms.
Long chain acyl acidic amino acid monosalt, (B) amphipathic substance, (C) water, and (A) long chain having 16 or more carbon atoms
The amount of the N-long-chain acyl acidic amino acid monosalt having an acyl group is 0.5 part by weight to 100 parts by weight of water (C).
5 parts by weight , and the molar ratio of (A) and (B) is from 1: 1 to
It is characterized by being 1: 5 .

Further, in the composition according to the present invention,
It is more preferable that the molar ratio of (A) and (B) is 1: 2 to 1: 4.

Further, in the composition according to the present invention,
(B) The amphipathic substance preferably contains at least one kind of higher alcohol or higher fatty acid having 12 or more carbon atoms, or N-long chain acyl acidic amino acid having an acyl group having 12 or more carbon atoms. is there.

Further, in the composition according to the present invention,
(B) The amphipathic substance further contains at least one kind of higher alcohol or higher fatty acid having 16 or more carbon atoms, or N-long chain acyl acidic amino acid having an acyl group having 16 or more carbon atoms. It is suitable. Further, in the composition according to the present invention, N-long-chain acyl acidic amino acid di-salt is present, and the amount thereof is 0.25 times the molar amount of (A) N-long-chain acyl acidic amino acid mono salt. The following is preferable.

Further, in the composition according to the present invention,
It is preferable that (A) N-long-chain acyl acidic amino acid monosalt and (B) amphipathic substance form an association in water. Further, in the composition according to the present invention, the pH of the composition is preferably 5.5 to 7. A liquid oil-in-water emulsion composition according to the present invention is characterized by containing at least one of the thickening composition and (D) oil.

In the emulsion composition according to the present invention, (D) / ((A) + (B) + (C)) = 1/99 to
It is preferable to include in the range of 80/20. Further, in the emulsion composition according to the present invention, it is preferable that the viscosity thereof is 500 to 10,000 cps at 25 ° C.

[0017]

BEST MODE FOR CARRYING OUT THE INVENTION Embodiments of the present invention will be described in detail below. In the present invention, the N-long-chain acyl acidic amino acid of the N-long-chain acyl acidic amino acid monosalt is
A long-chain acyl group is covalently bonded to the nitrogen atom of an acidic amino acid, and an N-long-chain acyl acidic amino acid monosalt is one carboxyl group of a plurality of carboxyl groups of the N-long-chain acyl acidic amino acid. It means neutralized salt.

The long-chain acyl group bonded to the acidic amino acid may be linear or branched, and may be saturated or unsaturated. The long-chain acyl group has 16 or more carbon atoms . When the number of carbon atoms is small and the chain length is short, an aggregate may not be formed or sufficient gelling ability may not be obtained.

The N-long chain acyl acidic amino acid monosalt used in the present invention is, for example, N-stearoyl-L.
-Glutamic acid monosalt, N-palmitoyl-L-glutamic acid monosalt, N-myristoyl-L-glutamic acid monosalt , N-coconut oil-L-glutamic acid monosalt, N-stearoyl-L-aspartic acid monosalt, N-palmitoyl -L-aspartic acid monosalt, N-myristoyl-L
-Aspartic acid monosalt , N-coconut oil-L-aspartic acid monosalt, N-long chain acyl-L-aspartic acid monosalt, N-stearoyl-4-aminobutyric acid monosalt, N-palmitoyl-4-aminobutyric acid Monoshio, N- myristoyl-4-aminobutyric acid mono salt, N- coconut oil 4-aminobutyric acid mono salt.

The counter ion of the N-long chain acyl acidic amino acid is not particularly limited, but for example, sodium, potassium, triethanolamine, arginine and the like are preferable.
As the N-long chain acyl acidic amino acid monosalt used in the present invention, sodium salt, potassium salt, triethanolamine salt and the like may be used as they are, and the N-long chain acidic acidic amino acid contained in the system is hydroxylated. You may use what was neutralized using sodium, potassium hydroxide, triethanolamine, etc.

The N-long-chain acyl acidic amino acid has at least two carboxyl groups in the molecule, and the N-long-chain acyl acidic amino acid of acidic form changes from N-long chain acyl acidic amino acid to N as the carboxyl group neutralization ratio increases in water. -The form is changed to a long-chain acyl acidic amino acid mono salt and an N-long-chain acyl acidic amino acid di salt.

For example, the N-long-chain acyl acidic amino acid is N
In the case of -stearoyl-L-glutamic acid, one amino group and two carboxyl groups are present in one molecule, and when the neutralization rate is 0, as shown in (1-a) of FIG. It is thought that all are present in acidic form. When alkali, such as sodium hydroxide, is added to the mixture for neutralization, the proportion of monosodium salt type (1-b) gradually increases, and at a neutralization rate of 50%, all N-stearoyl-L-
Glutamic acid is considered to be in the monosodium salt form (1-b). When sodium hydroxide is further added, the monosodium salt type becomes the disodium salt type (1-c).
Therefore, at a neutralization rate of 100%, all N-stearoyl-
It is considered that L-glutamic acid becomes a disodium salt type (1-c).

As described above, the N-long-chain acyl acidic amino acid changes its form depending on the neutralization ratio, but the acidic form of the N-long-chain acyl acidic amino acid is used as the amphipathic substance of the present invention as described later. Is possible. For example, when an alkali is used in combination with N-stearoyl-L-glutamic acid so that the neutralization rate is 25%, N-stearoyl-
The molar ratio of the acidic form and the monosalt form of L-glutamic acid is considered to be 1: 1. Each of them acts as an amphipathic substance and an N-long chain acyl acidic amino acid monosalt, and the aqueous phase Can be thickened and gelled. As will be described later, from the range of a suitable mixing molar ratio of the N-long-chain acyl acidic amino acid monosalt and the amphipathic substance, the N-long-chain acyl acidic amino acid mono-salt and the acidic form of the N-long-chain acyl acidic amino acid are When present, the amount of the acid type present is preferably equal to or less than the amount of the mono salt present in a molar ratio.

On the other hand, the N-long-chain acyl acidic amino acid di-salt also forms an association product with the amphipathic substance, but it is more gel than the association product formed between the mono-salt and the amphipathic substance. It has low chemical potential and cannot exert its full effect. Further, when the di-salt is used, the pH of the system becomes 11 or more and becomes a strong alkali, which is not suitable for practical use. Therefore, when the N-long-chain acyl acidic amino acid and the alkali are separately added to form the N-long-chain acyl acidic amino acid monosalt in the system, if the alkali is excessively added, the N-long-chain acyl acidic amino acid is mixed. The ratio of the acidic amino acid present as the di-salt type is large, and the sufficient amount of the mono-salt type is present, so that sufficient gelling ability cannot be obtained. The abundance is 1 in molar ratio with respect to monosalt
It is necessary that the amount is not more than the double amount, more preferably not more than 0.25 times the amount, and particularly preferably blended so as to be not more than 0.1 times the amount.

Examples of the alkali for neutralizing the N-long chain acyl acidic amino acid include potassium hydroxide, sodium hydroxide, triethanolamine and the like. In the present invention, the amphipathic substance is a substance that has surface activity but is highly hydrophobic in itself and does not have surface activity as much as a general surfactant, and examples thereof include higher fatty acids, higher aliphatic alcohols, monoglycerides, and glycerol. Examples thereof include monoalkyl ethers, monoalkylamines, and sterols, and as described above, free N
It is also possible to use long-chain acyl acidic amino acids.
Of these, higher fatty acids, higher aliphatic alcohols, and N-long-chain acyl acidic amino acids are preferable, and higher fatty acids and higher aliphatic alcohols are particularly preferable.

The higher fatty acid and the higher aliphatic alcohol preferably have 12 or more carbon atoms, particularly 1 carbon atom.
It is preferably 6 or more. The N-long-chain acyl acidic amino acid preferably has a long-chain acyl group having 12 or more carbon atoms, as in the case of the N-long-chain acyl acidic amino acid monosalt, and particularly preferably has 16 or more carbon atoms. Preferably there is. When the number of carbon atoms is small, an aggregate may not be formed with the N-long chain acyl acidic amino acid monosalt, or sufficient gelability may not be obtained.

Specific examples include lauric acid, myristic acid, palmitic acid, stearic acid and behen (behenin).
Acid, oleic acid, 12-hydroxystearic acid, undecylenic acid, tallic acid, isostearic acid, linoleic acid,
Higher fatty acids such as linoleic acid, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), N-stearoyl-L-glutamic acid, N-palmitoyl-L-glutamic acid, N-myristoyl-L-glutamic acid, N
-Lauryl-L-glutamic acid, N-coconut oil-L-glutamic acid, N-stearoyl-L-aspartic acid, N
-Palmitoyl-L-aspartic acid, N-myristoyl-L-aspartic acid, N-long chain acyl-L-aspartic acid, N-lauryl-L-aspartic acid, N-coconut oil-L-aspartic acid, N-stearoyl N-long chain acyl such as 4-aminobutyric acid, N-palmitoyl-4-aminobutyric acid, N-myristoyl-4-aminobutyric acid, N-lauryl-4-aminobutyric acid, N-coconut oil-4-aminobutyric acid Linear amino acids such as acidic amino acids, lauryl alcohol, cetyl alcohol, stearyl alcohol, behenyl alcohol, myristyl alcohol, oleyl alcohol, cetostearyl alcohol, higher grades such as monostearyl glycerin ether (batyl alcohol), 2-decyltetradecinol, and lanolin alcohol. Fatty alcohol, choles Roll, sterols such as phytosterols, monoglycerides, glycerol monoalkyl ethers, monoalkyl amines.

In the thickened gel composition of the present invention, N-
The long-chain acyl acidic amino acid monosalt and the amphipathic substance form an aggregate in water, which can thicken the aqueous phase. The formation of a gel with an N-long-chain acyl acidic amino acid monosalt and an amphipathic substance has not been reported so far, and it has been clarified for the first time by the present invention.

The formation of an association between the N-long-chain acyl acidic amino acid monosalt and the amphipathic substance can be confirmed by DSC (differential scanning calorimeter) measurement. Hereinafter, as a specific example, N-stearoyl-L-glutamic acid monosodium salt (molecular weight about 435) is used as the N-long-chain acyl acidic amino acid monosalt, and behenyl alcohol (molecular weight about 326) is used as the amphipathic substance. explain.

FIG. 2 shows a system consisting of N-stearoyl-L-glutamic acid monosodium salt (hereinafter referred to as monosalt), behenyl alcohol and water in which the molar ratio of N-stearoyl-L-glutamic acid monosodium salt to behenyl alcohol is changed. The change of the temperature rising curve at the time of preparing an aqueous solution and performing DSC measurement on the aqueous solution is shown. The aqueous solution was prepared by mixing the components, heating and dissolving the mixture, and allowing it to cool. Further, in the present invention, the DSC (differential scanning calorimeter) measurement is specifically carried out by using DSC120 (manufactured by Seiko Denshi Kogyo Co., Ltd.), and the endotherm observed in the obtained DSC temperature rising curve. The temperature at the top of the peak was taken as the transition temperature.

In FIG. 2, an endothermic peak of a hydrate of a monosalt is observed around 43 ° C. in an aqueous solution of N-stearoyl-L-glutamic acid monosodium salt alone. When the ratio of behenyl alcohol to the monosalt increases, the endothermic peak of the monosalt gradually decreases, and instead, an aggregate peak appears at around 76 ° C., which is different from the endothermic peak of behenyl alcohol. The endothermic peak of this aggregate gradually increases as the molar ratio of behenyl alcohol increases. Then, when the molar ratio of behenyl alcohol to the monosalt is around 1: 3, almost only the peak of the aggregate around 76 ° C. is detected singly. Furthermore, when the molar ratio of behenyl alcohol exceeds 1: 3 and increases, the endothermic peak of behenyl alcohol comes to be detected at around 69 ° C.

From this fact, the aggregate gel is 76
It can be seen that it does not break below ℃ and has excellent high temperature stability.
Preferred amphiphiles or mixtures thereof can be selected by such measurements. That is, it is a necessary condition that a peak of a newly formed aggregate is generated, and the transition temperature thereof is preferably 60 ° C or higher, more preferably 70 ° C or higher. Tables 1 and 2 show the composition ratios of the aqueous solutions having the respective molar ratios, properties, viscosities, and pHs. In addition, these evaluations were performed by the method described later.

[0033]

[Table 1] ────────────────────────────────────        Component amount (% by weight) ──────────────────────────────────── N-stearoyl-L-glutamic acid Na 2 2 2 2 2 2 2 2 behenyl alcohol                  0 0.3 0.5 0.75 1.5 2 3 Ion-exchanged water 100 100 100 100 100 100 100 ────────────────────────────────────   Molar ratio (:) − 5: 1 3: 1 2: 1 1: 1 1: 1.3 1: 2 ────────────────────────────────────   Properties Liquid Liquid Little Viscous Viscous Liquid Gel Gel Gel   Viscosity (cps) 3 100 400 500 1400 1800 2000   pH 7.48 7.19 7.03 6.92 6.79 6.72 6.55 ────────────────────────────────────

[0034]

[Table 2] ────────────────────────────────────        Component amount (% by weight) ──────────────────────────────────── N-stearoyl-L-glutamic acid Na 2 2 2 2 2 2 behenyl alcohol                  4 4.5 6 7.5 8 10 Ion-exchanged water 100 100 100 100 100 100 ────────────────────────────────────   Molar ratio (:) 1: 2.7 1: 3 1: 4 1: 5 1: 5.3 1: 6.7 ────────────────────────────────────   Properties Gell Gell Gell Solid Phase Deposition Solid Phase Deposition Out   Viscosity (cps) 2400 3100 3500 3800 4300 6500   pH 6.44 6.4 6.45 6.45 6.41 6.41 ────────────────────────────────────

As can be seen from Tables 1 and 2, the system thickened as the amount of behenyl alcohol added increased, and a good gel composition was obtained when the molar ratio of monosalt to behenyl alcohol was about 1: 1 to 1: 5. was gotten. On the other hand, when the molar ratio of behenyl alcohol was 1: 5 or more, the viscosity was not changed so much, but the smoothness in use was deteriorated, and the precipitation of higher alcohol was also observed in appearance.

From the above, it is considered that the N-long-chain acyl acidic amino acid monosalt and the amphipathic substance form an association in water, and this association causes the aqueous phase to gel. In order to obtain a sufficient gelling ability and a good feeling in use in the present invention, a suitable blending molar ratio of the N-long chain acyl acidic amino acid monosalt to the amphipathic substance is 1: 1 to 1: 5, particularly 1:
It is understood that it is 2-1: 4.

The transition temperature of the aggregate (about 76 ° C. in the case of the aggregate of N-stearoyl-L-glutamic acid monosodium salt and behenyl alcohol) is higher than that of the hydrate of N-long-chain acyl acidic amino acid monosalt. Since it is on the high temperature side and the aggregate does not break below this transition temperature, N
It is possible to obtain a thickened gel composition excellent in high temperature stability as compared with the case of using a long-chain acyl acidic amino acid monosalt alone.

When a similar test was carried out using a disodium salt instead of the monosodium salt, the endothermic peak of the aggregate was observed by DSC measurement, but its strength was low and sufficient gelling ability was observed. It was not demonstrated. For example,
2 parts by weight of disodium salt, 4.5 parts by weight of behenyl alcohol, 100 parts by weight of deionized water have a viscosity of 1.00.
The gelling ability was 0, which was about 1/3 that of the monosalt. Furthermore, when the pH of the system was measured, it showed a value of 12 or more, and a slimy feeling was generated. From these, it is easily understood that the use of di-salt causes a problem in safety and usability when applied to the skin and the like, and is not suitable as an external preparation for skin and the like.

Next, the present inventors also examined the properties of the system and the feeling of use depending on the amount of the N-long-chain acyl acidic amino acid monosalt compounded. That is, N-stearoyl-L-glutamic acid monosodium salt was used as the N-long-chain acyl acidic amino acid monosalt, and behenyl alcohol was used as the amphipathic substance. Predetermined amounts shown in Tables 3 and 4 were mixed with water at 80 ° C. Each sample liquid was prepared by dissolving with stirring and cooling. In addition, in the table, the compounding amount is shown by weight%. Also,
Regarding the sample solution in which N-stearoyl-L-glutamic acid monosodium salt was used in combination with behenyl alcohol, the molar ratio of both was fixed to about 1: 2.7. The sample liquids 1 to 8 were evaluated for properties, pH, viscosity, stability, and feeling of use. The evaluation method is as follows.

Properties The appearance was visually observed. pH Measured with a pH meter. Viscosity Using a Vismetron rotational viscometer (made by Shibaura System Co., Ltd.), the rotor No. The measurement was performed under the conditions of 3, 25 ° C. and 12 rpm. Stability The sample solution was stored at 0 ° C., room temperature and 50 ° C., and changes in properties and viscosity were examined. The storage period was 50 ° C. for 1 month, and the rest was 6 months. Feeling of use Apply the sample solution to the backs of the hands of 20 healthy female panelists,
A questionnaire survey was conducted on the feeling of use at that time, and evaluation was made according to the following criteria. ○ ... When there are 4 or less panelists who feel slimy. Δ: 5 to 10 panelists who felt slimy. × ... When there are 10 or more panelists who feel slimy.

[0041]

[Table 3] ────────────────────────────────────       Sample solution No. 1 2 3 4 5 6 ──────────────────────────────────── N-stearoyl-L-glutamic acid Na 0 0.1 0.2 0.4 0.5 2 Behenyl alcohol                4 0.2 0.4 0.8 1.0 4 Ion-exchanged water 100 100 100 100 100 100 ────────────────────────────────────  Property Separation Separation Separation A little viscous gel gel  Viscosity 3 5 10 200 1,200 2,800  pH 7 6.75 6.35 6.35 6.35 6.4  Stability − − − ○ ○ ○  Feeling (slimming) − − − ○ ○ ○ ────────────────────────────────────

[0042]

[Table 4] ────────────────────────────────────       Sample solution No. 7 8 9 10 11 ──────────────────────────────────── N-Stearoyl-L-Glutamic acid Na 4 5 10 5 10 Behenyl alcohol                8 10 20 0 0 Ion-exchanged water 100 100 100 100 100 ────────────────────────────────────  Property Gell Gell Gell Gell  Viscosity 6,700 12,000 23,000 6,800 11,000  pH 6.44 6.45 6,42 7.06 6.51  Stability ○ ○ ○ × ×  Feeling (sliminess) ○ ○ × × × ────────────────────────────────────

Even when the amphipathic substance (behenyl alcohol) is used alone as in the sample liquid 1 or when the monosalt and the amphipathic substance are used in combination as in the sample liquids 2 to 4, the compounding amount of the monosalt is 0.4. When the content was less than 10% by weight, the amphipathic substance was separated from water, and the viscosity was low and sufficient thickening gelling ability was not obtained. Further, in the sample liquids 10 and 11 which are systems of N-long chain acyl acidic amino acid monosalt alone, although pH is neutral to weakly acidic and the system can be gelled, high temperature stability is poor, and The stickiness was great.

On the other hand, as with the sample solutions 5 to 9, N-
Long-chain acyl acidic amino acid monosalt (N-stearoyl-L
-Glutamic acid monosodium salt) and an amphipathic substance were used in combination, and in any system in which at least 0.5% by weight or more of the monosalt was mixed, the system could be thickened and gelled. The gelling ability can be understood by comparing the sample liquid 8 with the sample liquid 10 and the sample liquid 9 with the sample liquid 11, for example,
By using the monosalt and the amphipathic substance in combination, it was possible to obtain a gelling ability about twice that of the monosalt alone.
Moreover, all the sample solutions were very excellent in high temperature stability as compared with the case of using monosalt alone.

In addition, in a system in which a monosalt and an amphipathic substance are used in combination, the viscosity can be further increased by increasing the amount of the monosalt. If it exceeds 5 parts by weight with respect to 100 parts by weight of water, a slimy feeling is felt when applied to the skin,
In addition, when applied, the touch was rather hard, and the usability tended to be poor. Therefore, the N-long-chain acyl acidic amino acid monosalt and the amphipathic substance are used in combination, and the blending amount of the N-long-chain acyl acidic amino acid monosalt is 0.5 to 100 parts by weight of water.
When the amount is 5 parts by weight, good gelling ability, usability and stability can be obtained.

As described above, the inventors of the present invention formed a thermodynamically stable aggregate of a monosalt of N-long-chain acyl acidic amino acid and an amphipathic substance in water to thicken and gelate the system. It was found that, when such an aggregate is used, a high thickening and gelling ability can be obtained in a very small amount range of N-long-chain acyl acidic amino acid salt used that does not cause sliminess, and it is stable. It has been found that a thickened gel composition excellent in properties, safety and usability can be obtained.

The thickened gel composition according to the present invention can be applied to medicines, cosmetics and the like, and is suitable for, for example, a skin external preparation. The moisturizing effect can be enhanced by adding a polyhydric alcohol or a moisturizing agent to the thickened gel composition of the present invention within a range not impairing the effect of the present invention.

For example, as the polyhydric alcohol, ethylene glycol, propylene glycol, trimethylene glycol, 1,2-butylene glycol, 1,3-butylene glycol, tetramethylene glycol, 2,3-
Butylene glycol, pentamethylene glycol, 2-
Dihydric alcohols such as butene-1,4-diol, hexylene glycol and octylene glycol, trihydric alcohols such as glycerin, trimethylolpropane, 1,2,6-hexanetriol, and tetrahydric alcohols such as pentaerythritol. Alcohols, pentavalent alcohols such as xylitol, hexavalent alcohols such as sorbitol and mannitol, polyhydric alcohols such as diethylene glycol, dipropylene glycol, triethylene glycol, polypropylene glycol, triglycerin, tetraglycerin and polyglycerin Combined, ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol nomobutyl ether, ethylene glycol monophenyl ether, ethylene glycol monohexyl ether Le, ethylene glycol mono -2
-Methylhexyl ether, ethylene glycol isoamyl ether, ethylene glycol benzyl ether,
Divalent alcohol alkyl ethers such as ethylene glycol isopropyl ether, ethylene glycol dimethyl ether, ethylene glycol diethyl ether, ethylene glycol dibutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol monobutyl ether, diethylene glycol dimethyl ether, diethylene glycol diethyl ether, diethylene glycol diether Butyl ether, diethylene glycol methyl ethyl ether, triethylene glycol monomethyl ether, triethylene glycol monoethyl ether, triethylene glycol monoethyl ether, propylene glycol monomethyl ether, propylene glycol monoethyl ether Divalent alcohol alkyl ethers such as propylene glycol monobutyl ether, propylene glycol monoisopropyl ether, dipropylene glycol methyl ether, dipropylene glycol ethyl ether, dipropylene glycol butyl ether, ethylene glycol monomethyl ether acetate, ethylene glycol monoethyl ether acetate, Ethylene glycol monobutyl ether acetate, ethylene glycol monophenyl ether acetate, ethylene glycol diabate, ethylene glycol disuccinate, ethylene glycol monoethyl ether acetate, diethylene glycol monobutyl ether acetate, propylene glycol monomethyl ether acetate, propylene glycol Monoethyl ether acetate, propylene glycol monopropyl ether acetate, dihydric alcohol ether esters such as propylene glycol monomethyl ether acetate, hexyl alcohol, selachyl alcohol, glycerol monoalkyl ethers such as batyl alcohol,
Sugar alcohols such as sorbitol, maltitol, maltotriose, mannitol, sucrose, erythritol, glucose, fructose, starch-decomposing sugar, maltose, xylitose, starch-decomposing sugar reducing alcohol,
Glysolid, tetrahydrofurfuryl alcohol,
POE tetrahydrofurfuryl alcohol, POP butyl ether, POP / POE butyl ether, chill polyoxypropylene glycerin ether, POP glycerin ether, POP glycerin ether phosphate, PO
P.POE pentaerythritol ether and the like can be mentioned.

As the moisturizing agent, chondroitin sulfate, hyaluronic acid, mucoitin sulfate, caronic acid, atelocollagen, cholesteryl-12-hydroxystearate, sodium lactate, bile acid monosalt, dl-pyrrolidone carboxylic acid monosalt, short chain soluble collagen , Isosa yoyobara extract, and yarrow extract.

The thickened gel-like composition of the present invention may be an emulsified composition such as cream, emulsion, beauty essence, lotion or the like, or a solubilized composition. For example, in the case of an oil-in-water emulsion composition, N is added to the composition previously emulsified by a general method.
A method for obtaining a desired thickened gel composition by mixing a long-chain acyl acidic amino acid monosalt, an amphipathic substance, and a thickened gel composition composed of water, an amphipathic substance in an oil phase, and an aqueous phase N-
Examples of the method include adding a long-chain acyl acidic amino acid monosalt and emulsifying the composition to obtain the desired thickened gel-like composition. In any case, an aggregate is formed within the quantitative range of the present invention. The system becomes a thickened gel and can be a composition excellent in stability and usability. Such compositions are also within the scope of the thickened gel-like composition of the present invention. In addition, previously prepared N-long-chain acyl acidic amino acid monosalt, amphipathic substance,
A method of mechanically emulsifying by adding and mixing an oil component to a thickened gel composition composed of water is also possible.

On the other hand, the oil-in-water emulsion composition according to the present invention has a viscosity of 500 to 10,000 cps at a rotation speed of 60 rpm using a B type viscometer at 25 ° C. 500c
It is difficult to stabilize below ps, and 10,000
At cps or higher, the state is close to that of cream. The preferred viscosity is 700 to 70 in terms of stability and use feeling.
It is 00 cps. In the oil-in-water emulsion composition according to the present invention, the combined amount of the N-long chain acyl acidic amino acid monosalt and the amphipathic substance is preferably 0.8% or more and 7% or less. If it is 0.8% or less, it is difficult to stabilize against creaming, and if it is 7% or more, a fluid oil-in-water emulsion composition cannot be prepared and a cream is formed. The preferred range is 1% to 5%.

In the oil-in-water emulsion composition according to the present invention, the oily component to be mixed in the system may be a liquid oil component, a solid oil component, a semi-solid oil component, or a water-insoluble substance. For example, avocado Oil, camellia oil, turtle oil, macadamia nut oil, corn oil, mink oil, olive oil, rapeseed oil, egg yolk oil, sesame oil, persic oil, wheat germ oil,
Southern oil, castor oil, linseed oil, safflower oil, cottonseed oil, eno oil, soybean oil, peanut oil, teaseed oil, kaya oil, rice bran oil, cinnamon oil, Japanese tallow oil, jojoba oil, germ oil,
Triglycerin, glyceryl trioctanoate, glyceryl triisopalmitate, cocoa butter, coconut oil, horse fat, hardened coconut oil, palm oil, beef tallow, sheep fat, hardened beef tallow, palm kernel oil, lard, beef bone fat, mokuro kernel Oil, hydrogenated oil, beef tallow, mokuro, hydrogenated castor oil, beeswax, candelilla wax, cotton wax, carnauba wax, bayberry wax, ivorot wax,
Whale wax, montan wax, nuka wax, lanolin, kapok wax, lanolin acetate, liquid lanolin, sugar cane wax,
Lanolin fatty acid isopropyl, hexyl laurate, reduced lanolin, jojoba wax, hard lanolin, shellac wax, POE lanolin alcohol ether, POE lanolin alcohol acetate, POE cholesterol ether,
Lanolin fatty acid polyethylene glycol, POE hydrogenated lanolin alcohol ether, hydrocarbon oil as liquid paraffin, ozokerite, squalene, pristane, paraffin, ceresin, squalene, petrolatum, microcrystalline wax, ester oil as diethyl phthalate, cholesterol isostearate And the like. Among them, the melting point is lower than room temperature and is distinguished from liquid oil, and the melting point is higher than room temperature is distinguished from solid and semi-solid oil. In addition to these oily components, chain polysiloxanes such as dimethylpolysiloxane, methylphenylpolysiloxane, methylhydrogenpolysiloxane, octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane, tetra Cyclic polysiloxane such as methyltetrahydrogencyclotetrasiloxane, amino-modified silicone oil, epoxy-modified silicone oil, epoxy-polyether-modified silicone oil, polyether-modified silicone oil, carboxy-modified silicone oil, alcohol-modified silicone oil, alkyl-modified silicone Silicone resins capable of forming a three-dimensional network structure such as oil, ammonium salt-modified silicone oil, fluorine-modified silicone oil, trimethylsiloxysilicic acid, or the like, Polymerization dimethylpolysiloxane, can be formulated highly polymerized methylphenylsiloxane, highly polymerized methyl polysiloxane, such as highly polymerized methylvinylpolysiloxane, silicone oils such as highly polymerized amino-modified methylpolysiloxane. In addition, as substances that are poorly soluble in water, para-aminobenzoic acid (hereinafter referred to as PABA), PABA monoglycerin ester, N, N-dipropoxy PABA ethyl ester,
N, N-diethoxy PABA ethyl ester, N, N-dimethyl PABA
Ethyl ester, N, N-dimethyl PABA butyl ester, N,
Benzoic acid type ultraviolet absorbers such as N-dimethyl PABA tyl ester, anthranilic acid type ultraviolet absorbers such as homomenthyl-N-acetylanthranilate, amyl salicylate,
Salicylic acid UV absorbers such as menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p-isopropanol phenyl salicylate, octylcinnamate, ethyl-4-isopropylcinnamate, methyl-2,5
-Diisopropylcinnamate, ethyl-2,4-diisopropylcinnamate, methyl-2,4-diisopropylcinnamate, propyl-p-methoxycinnamate, isopropyl-p-methoxycinnamate, isoamyl-p-methoxycinnamate, octyl -p-Methoxycinnamate
(2-ethylhexyl-p-methoxycinnamate), 2-ethoxyethyl-p-methoxycinnamate, cyclohexyl-p-methoxycinnamate, ethyl-α-cyano-β
-Phenylcinnamate, 2-ethylhexyl-α-cyano
cinnamic acid type UV absorbers such as β-phenyl cinnamate, glyceryl mono-2-ethylhexanoyl-diparamethoxycinnamate, 2,4-dihydroxybenzophenone,
2,2'-dihydroxy-4-methoxybenzophenone, 2,2 '
-Dihydroxy-4,4'-dimethoxybenzophenone, 2,
2 ', 4,4'-Tetrahydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid monosalt , 4-phenylbenzophenone, 2-ethylhexyl-4'-phenyl-benzophenone-2-carboxylate, 2-hydroxy-4-n-
Benzophenone-based UV absorbers such as octoxybenzophenone and 4-hydroxy-3-carboxybenzophenone,
3- (4'-methylbenzylidene) -d, 1-camphor, 3-benzylidene-d, 1-camphor, urocanic acid, urocanic acid ethyl ester, 2-phenyl-5-methylbenzoxazole, 2,2'- Hydroxy-5-methylphenylbenzotriazole, 2- (2'-hydroxy-5'-t-octylphenyl)
Benzotriazole, 2- (2'-hydroxy-5'-methylphenylbenzotriazole, dibenzalazine, dianisoylmethane, 4-methoxy-4'-t-butyldibenzoylmethane, 5- (3,3-dimethyl-2- UV absorbers such as norbornylidene) -3-pentan-2-one, preservatives such as parabens, vitamins such as ubiquinone and vitamin P, chlorhexidine hydrochloride, trichlorocarbanilide, imegassan DP3
Examples thereof include bactericides such as 00 and drugs such as dexamethasone acetate.

In the liquid oil-in-water emulsion composition of the present invention, the emulsion composition can be formed without adding a surfactant, but a small amount of a surfactant is added to obtain further emulsion stability. It can also be added.

Examples of the ionic surfactant include soap-like base, fatty acid soap such as sodium laurate and sodium palmitate, higher alkyl sulfate ester salt such as sodium lauryl sulfate and potassium lauryl sulfate, POE lauryl sulfate triethanolamine. , PO
E Alkyl ether sulfate ester salts such as sodium lauryl sulfate, N-acyl sarcosinic acid such as sodium lauroyl sarcosine, N-myristoyl-N-methyl taurine sodium, coconut oil fatty acid methyl tauride sodium, higher fatty acids such as sodium lauryl methyl tauride Amidosulfonic acid monosalt, POE oleyl ether phosphate sodium, POE stearyl ether phosphate and other phosphate ester salts, sodium di-2-ethylhexyl sulfosuccinate, monolauroyl monoethanolamide polyoxyoxyethylene sulfosuccinate sodium,
Sulfosuccinic acid monosalts such as sodium lauryl polypropylene glycol sulfosuccinate, sodium linear dodecylbenzene sulfonate, triethanolamine linear dodecylbenzene sulfonate, alkylbenzene sulfonic acid monosalts such as linear dodecylbenzene sulfonate,
Hardened coconut oil fatty acid Glycerin higher fatty acid ester sulfate ester salt such as sodium sulfate, sulfated oil such as funnel oil,
POE alkyl ether carboxylic acid, POE alkyl allyl ether carboxylic acid mono salt, α-olefin sulfonic acid mono salt, higher fatty acid ester sulfonic acid mono salt, secondary alcohol sulfate ester salt, higher fatty acid alkylolamide sulfate ester salt, lauroyl monoethanol Anionic surfactants such as sodium amidosuccinate, ditriethanolamine N-palmitoyl aspartate and sodium caseinate, 2-undecyl-N, N, N-
(Hydroxyethylcarboxymethyl) -2-imidazoline sodium, 2-cocoyl-2-imidazolinium hydroxide-1-carboxyethyloxy disodium salt and other imidazoline-based amphoteric surfactants, 2-heptadecyl-N-carboxymethyl- Amphoteric surface-active substances such as betaine-based amphoteric surface active agents such as N-hydroxyethylimidazolinium betaine, lauryldimethylaminoacetic acid betaine, alkyl betaine, amidobetaine and sulfobetaine can be mentioned.

Examples of the nonionic surfactant include sorbitan monooleate, sorbitan isostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan trioleate and penta. Sorbitan fatty acid esters such as 2-ethylhexyl acid diglycerol sorbitan, tetra-2-ethylhexyl acid diglycerol sorbitan, monocotton oil fatty acid glycerin, monoerucic acid glycerin, sesquioleic acid glycerin, monostearate glycerin, α, α'-
Glycerin oleate pyroglutamate, glycerin monostearate glycerin polyglycerin fatty acid such as malic acid, propylene glycol fatty acid ester such as propylene glycol monostearate, hydrogenated castor oil derivative, lipophilic nonionic surfactant such as glycerin alkyl ether , POE sorbitan monooleate, PO
P of E sorbitan monostearate, POE sorbitan monooleate, POE sorbitan tetraoleate, etc.
OE sorbitan fatty acid esters, POE sorbit monolaurate, POE sorbit monooleate, PO
POE sorbit fatty acid esters such as E sorbit pentaoleate and POE sorbit monostearate,
POE glycerin monostearate, POE glycerin fatty acid ester such as POE glycerin triisostearate, POE monooleate, POE distearate, POE dioleate, POE fatty acid ester such as ethylene glycol distearate, POE lauryl ether, POE oleyl ether, POE stearyl POE alkyl ethers such as ether, POE behenyl ether, POE 2-octyldodecyl ether, POE cholestanol ether, POE octylphenyl ether, POE nonylphenyl ether, POE alkylphenyl ethers such as POE dinonylphenyl ether, Pluronics such as Pluronic Type POE / P
OP cetyl ether, POE / POP2-decyl tetradecyl ether, POE / POP monobutyl ether,
POE / POP hydrogenated lanolin, POE / POP alkyl ethers such as POE / POP glycerin ether, tetraPOE / tetraPOP ethylenediamine condensate such as Tetronic, POE castor oil, POE hydrogenated castor oil,
POE hydrogenated castor oil monoisostearate, POE hydrogenated castor oil triisostearate, POE hydrogenated castor oil monopyroglutamic acid monoisostearate diester,
POE hydrogenated castor oil POE such as maleic acid POE castor oil hydrogenated castor oil derivative, POE such as POE sorbit beeswax
Alkanol amides such as beeswax lanolin derivative, coconut oil fatty acid diethanolamide, lanolinic acid monoethanolamide, and fatty acid isopropanolamide, POE propylene glycol fatty acid ester, POE alkylamine, POE fatty acid amide, sucrose fatty acid ester, PO
Examples thereof include hydrophilic nonionic surfactants such as E nonylphenylformaldehyde condensate, alkylethoxydimethylamine oxide, and trioleylphosphoric acid.

Further, it is possible to add a water-soluble polymer to the extent that the feeling of use, pH and the like of the aqueous thickened gel composition or liquid oil-in-water emulsion composition of the present invention are not impaired. The natural water-soluble polymer, for example, gum arabic, tragacanth gum, galactan, guar gum, carob gum, karaya gum, carrageenan, pectin, agar,
Plant polymers such as quince seed (quince), algecoloid (duck extract), starch (rice, corn, potato, wheat), glycyrrhizic acid, microbial polymers such as xanthan gum, dextran, succinoglucan, pullulan, collagen, Animal-based polymers such as casein, albumin and gelatin can be mentioned.

As the semi-synthetic water-soluble polymer, for example,
Starch polymers such as carboxymethyl starch and methyl hydroxypropyl starch, methyl cellulose, nitrocellulose, ethyl cellulose, methyl hydroxypropyl cellulose, hydroxyethyl cellulose, sodium cellulose sulfate, hydroxypropyl cellulose, sodium carboxymethyl cellulose (CM
C), cellulose-based polymers such as crystalline cellulose and cellulose powder, and alginate-based polymers such as sodium alginate and propylene glycol alginate.

As the synthetic water-soluble polymer, for example, polyvinyl alcohol, polyvinyl methyl ether-based polymer, polyvinyl pyrrolidone, vinyl-based polymer such as carboxyvinyl polymer (CARBOPOL 940, 941; BF Goodrich), polyethylene glycol 20. 2,000, polyethylene glycol 6,000, polyethylene glycol 4,000, and other polyoxyethylene-based polymers, polyoxyethylene polyoxypropylene copolymers and other copolymer-based polymers, sodium polyacrylate, polyethyl acrylate, poly Acrylic polymer such as acrylamide,
Examples thereof include polyethyleneimine, cationic polymers, N-vinylpyrrolidone-N, N-dimethylaminoethylmethacrylic acid copolymer diethyl sulfate monosalt and the like. Examples of the inorganic water-soluble polymer include bentonite, magnesium aluminum silicate (veegum), laponite, hectorite, and silicic acid anhydride.

Further, the thickened gel composition of the present invention may contain other components which are usually blended in cosmetics and pharmaceuticals depending on the purpose and application. For example, B vitamins,
Vitamin C and its derivatives, pantothenic acid and its derivatives, water-soluble physiologically active substances such as vitamins such as biotin, sodium glutamate, arginine, aspartic acid, buffers such as citric acid, tartaric acid and lactic acid, chelating agents such as EDTA, In addition to various dyes, fragrances, preservatives and the like, powders, pigments and the like can be added.

Examples of the inorganic pigments include talc, kaolin, calcium carbonate, zinc white, titanium dioxide, red iron oxide, yellow iron oxide, black iron oxide, ultramarine blue, titanium coated mica, bismuth oxychloride, red iron oxide, and caking pigment. , Gunjo pink, chromium hydroxide, mica titanium, chromium oxide, aluminum oxide cobalt, navy blue, carbon black, silicic acid anhydride, magnesium silicate, bentonite,
Mica, zirconium oxide, magnesium oxide, zinc oxide, titanium oxide, light calcium carbonate, heavy calcium carbonate, light magnesium carbonate, light magnesium carbonate,
Examples include niramine.

Examples of the inorganic powders include, in addition to the above inorganic pigments, anhydrous silicic acid monosalt, sericite, nylon powder, polyethylene powder, cellulose powder, acrylic resin and the like. These inorganic powders and inorganic pigments may be blended as they are, or may be blended after being made hydrophobic by silicone treatment, fluorine treatment, metal soap treatment, and activator treatment. Further, in the oil phase dispersed phase, an oil-soluble drug, an antioxidant, an ultraviolet absorber such as octyl methoxycinnamate,
The above-mentioned lipophilic surfactant and the like can be added.

[0062]

[Examples] Specific examples of the thickened gel composition according to the present invention are shown below, but the present invention is not limited thereto. Unless otherwise specified, the blending amount is shown in% by weight.

Example 1 Gel-like beauty essence (1) N-stearoyl-L-glutamate monosodium 1.5% by weight (2) Behenyl alcohol 2.5 (3) Glycerin 5.0 (4) Ascorbic acid derivative 0.2 (5) Ion-exchanged water 90.8 (Production method) (1) to (5) are stirred and mixed at 80 ° C.,
The gel-like beauty essence was obtained by cooling to room temperature as it was.

Example 2 Gel whitening beauty liquid (1) N-stearoyl-L-glutamic acid 1.5% by weight (2) Behenyl alcohol 2.5 (3) Glycerin 5.0 (4) Arbutin 3.0 (5) Potassium hydroxide 0.1 (6) Ion-exchanged water 87.9 (Production method) (1) to (6) are stirred and mixed at 80 ° C.,
The gel-like beauty essence was obtained by cooling to room temperature as it was.

Example 3 Nutrition cream (1) Liquid paraffin 30.0% by weight (2) Pluronic 4.0 (3) Vitamin E acetate 0.2 (4) Paraben 0.2 (5) Perfume 0.1 (6) ) N-palmitoyl-L-glutamate monopotassium 1.5 (7) Stearic acid 1.5 (8) Glycerin 30.0 (9) Purified water 32.5 (Production method) (1) to (5) and (6). ~ (9) separately 70
The mixture was heated to C, and (1) to (5) were added to (6) to (9) with stirring to emulsify and then cooled to obtain a nutrition cream.

Example 4 Whitening beauty essence (1) Liquid paraffin 5.0% by weight (2) Vaseline powder 1.0 (3) Vitamin E acetate 0.2 (4) Placenta extract 0.2 (5) Methylparaben 0. 2 (6) N-stearoyl-L-glutamic acid 2.1 (7) Perfume 0.05 (8) N-stearoyl-L-glutamate monosodium 0.9 (9) Dynamite glycerin 7.0 (10) 1,3 -Butylene glycol 8.0 (11) Trisodium edetate 0.01 (12) Sodium 2-hydroxy-4-methoxybenzophenone-5-sulfonate 0.05 (13) Ion-exchanged water 75.29 (Production method) (1 )-(7) are mixed by stirring at 70 ° C. This is added to a solution obtained by heating and dissolving the mixed solution of (8) to (13) at 70 ° C. with stirring to emulsify. Then, it cooled and obtained the whitening beauty essence.

Example 5 Beauty essence (1) Behenyl alcohol 1.7% by weight (2) Stearyl alcohol 0.5 (3) N-stearoyl-L-glutamic acid 1.0 (4) Squalane 4.5 (5) 2- Cetyl ethylhexanoate 1.5 (6) L-ascorbic acid derivative 0.2 (7) Methylparaben 0.2 (8) Dynamite glycerin 8.0 (9) Potassium hydroxide 0.1 (10) Perfume 0.05 ( 11) Trisodium edetate 0.01 (12) Ion-exchanged water 82.24 (Production method) (1) to (5) are stirred and mixed at 70 ° C. This is added to a solution obtained by heating and dissolving the mixed solution of (6) to (12) at 70 ° C. with stirring to emulsify. Then, it cooled and obtained the beauty essence.

Example 6 Beauty essence (1) Behenyl alcohol 2.5% by weight (2) Stearic acid 1.0 (3) Squalane 3.5 (4) Cetyl 2-ethylhexanoate 1.0 (5) Octyl cinnamate 0.2 (6) Methylparaben 0.1 (7) N-stearoyl-L-glutamate monosodium 1.5 (8) Dynamite glycerin 5.0 (9) Perfume 0.05 (10) Trisodium edetate 0.01 (11) Ion-exchanged water 85.14 (Production method) (1) to (5) are stirred and mixed at 70 ° C. This is added to a mixture obtained by heating and dissolving the mixed solution of (6) to (11) at 70 ° C. with stirring to emulsify. Then, it cooled and obtained the beauty essence.

Example 7 Gel whitening cosmetic formulation A; (1) N-stearoyl-L-aspartate monosodium 1.0% by weight (2) Behenyl alcohol 2.0 (3) Purified water 97.0 Formula B; (1) Squalane 40.0 (2) Stearic acid 2.0 (3) Paraben 0.1 (4) Perfume 0.1 (5) Triethanolamine 1.0 (6) Propylene glycol 20.0 (7) Arbutin 3.0 (8) Purified water 33.8 (Manufacturing method) Formula A was prepared by stirring and mixing (1) to (3) at 80 ° C. to dissolve them, followed by cooling to obtain a gel composition. Formulation B was emulsified by a conventional method to give an oil-in-water emulsion composition. 70 g of the gel composition obtained in Formulation A and 30 g of the emulsion obtained in Formulation B were mixed and cooled to 25 ° C. to obtain a gel whitening cosmetic composition.

Example 8 Gel-type beauty essence formulation A; (1) N-stearoyl-L-glutamate monopotassium 1.2% by weight (2) Behenyl alcohol 1.9 (3) Paraben 0.1 (4) Purified water 96 .8 Formulation B; (1) squalane 20.0 (2) stearic acid 2.0 (3) fragrance 0.1 (4) triethanolamine 1.0 (5) propylene glycol 20.0 (6) ascorbic acid derivative 1.0 (7) Carbopol 940 0.05 (8) Potassium hydroxide 0.2 (9) Purified water 55.65 (Production method) Formula A was prepared by stirring and mixing (1) to (4) at 80 ° C. It was dissolved and cooled as it was to obtain a gel composition. Formulation B was emulsified by a conventional method to give an oil-in-water emulsion composition. 70 g of the gel composition obtained by the formulation A and 30 g of the emulsion obtained by the formulation B were mixed to obtain a gel cosmetic liquid.

Example 9 Gel-type beauty essence formulation A; (1) N-stearoyl-L-glutamate monosodium 1.5% by weight (2) Stearyl alcohol 0.5 (3) Behenyl alcohol 1.3 (4) Glycerin 5 0.0 (5) Dipropylene glycol 5.0 (6) Ascorbic acid derivative 1.2 (7) Ion-exchanged water 85.5 Formulation B; (1) Carbopol 940 0.06 (2) Sodium hydroxide 0.2 (3) Ion-exchanged water 99.74 (Preparation method) Formulation A was prepared by stirring and mixing (1) to (7) at 80 ° C. to dissolve, and then cooling to obtain a gel composition. Formulation B was prepared by mixing (1) to (4) with stirring at room temperature to obtain a gel composition. 90 g of the gel composition obtained by the formulation A
And 10 g of the gel composition obtained in Formulation B were mixed to obtain a gel cosmetic liquid.

The cosmetics obtained in Examples 1 to 9 above are
It had a pH of 5.5 to 7 and exhibited a gel form, and in addition, there was no slimy feeling or irritation, and the feeling of use was good. It was also excellent in stability over time and stability at high temperatures. Moreover, Examples 1 to 9
DSC measurement of the cosmetic of No. 2 showed an endothermic peak of the aggregate of the N-long-chain acyl acidic amino acid monosalt and the amphipathic substance.

Example 10 Liquid whitening emulsion (1) Squalane 9.0 (2) Vaseline P 1.0 (3) Vitamin E acetate 0.2 (4) Stearyl alcohol 1.8 (5) Placenta extract 0.2 ( 6) Methylparaben 0.2 (7) N-palmitoyl-L-glutamic acid 0.5 (8) N-stearoyl-L-glutamic acid Na 1.0 (9) Dynamite glycerin 7.0 (10) 1,3-butylene glycol 5.0 (11) Fragrance 0.05 (12) Trisodium edetate 0.01 (13) Ion-exchanged water The remaining amounts (1) to (3) are mixed with stirring at 70 ° C. This (4)
The mixture of (10) to (10) was heated and dissolved at 70 ° C., added with stirring, emulsified and then cooled to obtain a whitening emulsion. Viscosity in the above measurement method is 2000 cps, -5 ℃
It was stable at -40 ° C for 3 months or longer. Moreover, the feeling of use was also favorable.

Example 11 Liquid whitening emulsion (1) Behenyl alcohol 0.8 (2) Stearyl alcohol 0.4 (3) Squalane 7.0 (4) Cetyl 2-ethylhexanoate 3.0 (5) Arbutin 3.0 (6) Methylparaben 0.2 (7) N-stearyl-L-glutamate Na 0.5 (8) Dynamite glycerin 8.0 (9) Perfume 0.05 (10) Trisodium edetate 0.01 (11) ion Exchanged water The remaining amounts (1) to (4) are mixed with stirring at 70 ° C. This (5)
The mixture of (11) to (11) was heated and dissolved at 70 ° C., added with stirring, emulsified and then cooled to obtain a whitening emulsion. The viscosity in the above measuring method is 900 cps, -5 ° C ~
It was stable at 40 ° C. for 3 months or more. In addition, the feeling of use was very favorable.

Example 12 Liquid nutritional beauty liquid (1) Squalane 3.5 (2) Olive oil 6.5 (3) Beeswax 1.0 (4) Vaseline 2.0 (5) Vitamin E acetate 0.2 (6) ) Behenyl alcohol 1.8 (7) Behenic acid 1.0 (8) N-palmitoyl-4-aminobutyric acid Na 1.8 (9) Methylparaben 0.2 (10) Dynamite glycerin 7.0 (11) Triethanolamine 0 .1 (12) Fragrance 0.05 (13) Ion-exchanged water The remaining amounts (1) to (7) are mixed with stirring at 70 ° C. This (8)
The mixture liquids of (13) to (13) were added to the mixture heated and dissolved at 70 ° C. with stirring, emulsified and then cooled to obtain a whitening emulsion. The viscosity in the above measuring method is 5000 cps, -5 ° C
It was stable at -40 ° C for 3 months or longer. Moreover, the feeling of use was also favorable.

Example 13 Liquid emollient emulsion (1) Stearic acid 1.0 (2) Behenyl alcohol 2.7 (3) Liquid paraffin 5.0 (2) Olive oil 10.0 (4) Vaseline P 5.0 (5) Beeswax 3.0 (6) Methylparaben 0.2 (7) N-stearyl-L-glutamate Na 1.8 (8) Dynamite glycerin 10.0 (9) 1,3-Butylene glycol 5.0 (10) Perfume 0.1 (11) Ion-exchanged water The remaining amounts (1) to (5) are mixed by stirring at 70 ° C. This (5)
The mixture of (11) to (11) was heated and dissolved at 70 ° C., added with stirring, emulsified and then cooled to obtain a whitening emulsion. Viscosity in the above measurement method is 7000 cps, -5 ℃
It was stable at -40 ° C for 3 months or longer. Moreover, the feeling of use was also favorable.

Example 14 Liquid whitening emulsion (1) Squalane 7.5 (2) Polydimethylsiloxane 1.5 (3) Vitamin E acetate 0.5 (4) Methylparaben 0.2 (5) Behenyl alcohol 2.5 (6) ) N-myristoyl-L-glutamic acid 0.5 (7) N-stearoyl-L-glutamic acid Na 1.8 (8) arbutin 3.0 (9) dynamite glycerin 5.0 (10) 1,3-butylene glycol 3 0.0 (11) Perfume 0.05 (12) Trisodium edetate 0.01 (13) Ion-exchanged water The remaining amounts (1) to (5) are mixed with stirring at 70 ° C. This (6)
The mixture liquids of (13) to (13) were added to the mixture heated and dissolved at 70 ° C. with stirring, emulsified and then cooled to obtain a whitening emulsion. Viscosity in the above measurement method is 2000 cps, -5 ℃
It was stable at -40 ° C for 3 months or longer. Moreover, the feeling of use was also favorable.

Example 15 Liquid sun protector (1) Cetyl isooctanoate 10.0 (2) Stearyl alcohol 1.8 (3) Neopentyl glycol dicaprate 4.5 (4) Glyceryl mono-2-ethylhexanoyl 1.5-diparamethoxycinnamate (5) methylparaben 0.2 (6) N-palmitoyl-L-aspartic acid Na 1.2 (7) 1,3-butylene glycol 7.0 (8) dynamite glycerin 8. 0 (9) Perfume 0.05 (10) Ion-exchanged water The remaining amounts (1) to (4) are mixed with stirring at 70 ° C. This (5)
The mixture of (10) to (10) was heated and dissolved at 70 ° C., added with stirring, emulsified and then cooled to obtain a whitening emulsion. Viscosity in the above measurement method is 3000 cps, -5 ℃
It was stable at -40 ° C for 3 months or longer. Moreover, the feeling of use was also favorable.

Example 16 Liquid emollient emulsion (1) Behenic acid 0.4 (2) Stearic acid 0.2 (3) Behenyl alcohol 0.8 (4) Stearyl alcohol 0.4 (5) Liquid paraffin 5.0 (6) ) Olive oil 15.0 (7) Vaseline 7.0 (8) Shortening oil 3.0 (9) Bees wax 3.0 (10) N-stearyl-L-glutamate Na 1.2 (11) Dynamite glycerin 10.0 (12) Methylparaben 0.2 (13) Perfume 0.1 (14) Ion-exchanged water The remaining amounts (1) to (9) are mixed with stirring at 70 ° C. This is (1
The mixed solution of 0) to (14) was added to a solution which was heated and dissolved at 70 ° C. with stirring, emulsified and then cooled to obtain a whitening emulsion. The viscosity in the above measuring method is 2500 cps,
-Stable for 3 months or more at 5 to 40 ° C. or,
The feeling of use was also favorable.

Example 17 Liquid cleansing emulsion (1) Behenyl alcohol 0.8 (2) Cetyl isooctanoate 10.0 (3) Liquid paraffin 50.0 (4) Vaseline P 5.0 (5) Methylparaben 0.2 (6) N-stearyl-L-glutamic acid Na 0.4 (7) 1,3-butylene glycol 5.0 (8) Ion-exchanged water The remaining amounts (1) to (4) are mixed with stirring at 70 ° C. This (5)
The mixture solution of (8) to (8) was heated and dissolved at 70 ° C., added with stirring, emulsified and then cooled to obtain a whitening emulsion. The viscosity in the above-mentioned measuring method is 1500 cps, -5 ° C ~
It was stable at 40 ° C. for 3 months or more. Moreover, the feeling of use was also favorable.

Example 18 Liquid massage emulsion (1) Stearyl alcohol 0.5 (2) Behenyl alcohol 1.5 (3) Liquid paraffin 25.0 ( 4 ) Olive oil 15.0 ( 5 ) Vaseline P 15.0 ( 6 ) Beeswax 8.0 ( 7 ) Methylparaben 0.2 ( 8 ) N-stearyl-L-glutamic acid Na 0.8 ( 9 ) dynamite glycerin 2.0 ( 10 ) 1,3-butylene glycol 5.0 ( 11 ) Fragrance 0.05 ( 12 ) Ion-exchanged water The remaining amounts (1) to ( 5 ) are mixed with stirring at 70 ° C. This ( 6 )
The mixture of (11) to (11) was heated and dissolved at 70 ° C., added with stirring, emulsified and then cooled to obtain a whitening emulsion. The viscosity in the above measuring method is 4500 cps, -5 ° C
It was stable at -40 ° C for 3 months or longer. Moreover, the feeling of use was also favorable.

[0082]

EFFECTS OF THE INVENTION According to the thickened gel composition of the present invention, the N-long-chain acyl acidic amino acid monosalt and the amphipathic substance are used in combination so that the water can be used at a very low concentration of the surfactant. It is possible to obtain a weakly acidic thickened gel-like composition which is capable of forming a thickened gel in the phase and is excellent in stability, safety and usability. Further, according to the liquid oil-in-water emulsion composition of the present invention, it is possible to obtain an emulsion composition that is stable and has excellent feeling of use without using a large amount of other surfactants or thickening gelling agents. You can

[Brief description of drawings]

FIG. 1 is a diagram showing the existence form in water according to the neutralization rate of N-stearoyl-L-glutamic acid.

FIG. 2 shows N-stearoyl- according to an embodiment of the present invention.
It is a DSC measurement figure of the thickened gel composition which consists of monosodium L-glutamate, behenyl alcohol, and water.

─────────────────────────────────────────────────── ─── Continuation of the front page (72) Hideo Nakajima Inventor Hideo Nakajima, Shibaido Daiichi Research Center, 1050 Shinba-cho, Kohoku-ku, Yokohama-shi, Kanagawa (56) References Japanese Patent Laid-Open No. 1-100112 (JP, A) Kai 64-83011 (JP, A) JP 2-228387 (JP, A) JP 9-301847 (JP, A) JP 7-206666 (JP, A) JP 7-69829 ( JP, A) JP-A-6-145024 (JP, A) JP-A-6-57290 (JP, A) JP-A-5-17342 (JP, A) JP-A-56-106999 (JP, A) (58 ) Fields surveyed (Int.Cl. ⁷ , DB name) A61K ^7/ 00-7/50 C09K 3/00 103

Claims (10)

(57) [Claims] 1. (A) Long-chain acyl having 16 or more carbon atoms
A long chain having an N-long chain acyl acidic amino acid mono salt having a group , (B) an amphipathic substance, (C) water, and (A) having 16 or more carbon atoms
The amount of the N-long-chain acyl acidic amino acid monosalt having an acyl group is 0.5 part by weight to 100 parts by weight of water (C).
5 parts by weight , and the molar ratio of (A) and (B) is from 1: 1 to
Aqueous thickening gel-like composition characterized in that it is 1: 5 . 2. The composition according to claim 1, wherein (A)
An aqueous thickening gel composition, wherein the molar ratio of (B) and (B) is 1: 2 to 1: 4 . 3. The composition according to claim 1 , wherein the (B) amphipathic substance has a higher alcohol or fatty acid having 12 or more carbon atoms, or N having an acyl group having 12 or more carbon atoms. -Long-chain acyl acidic amino acid 1
An aqueous thickening gel-like composition comprising one or more species. 4. The composition according to claim 1 or 2 , wherein (B) the amphipathic substance has a higher alcohol or higher fatty acid having 16 or more carbon atoms, or N having an acyl group having 16 or more carbon atoms. -Long-chain acyl acidic amino acid 1
An aqueous thickening gel-like composition comprising one or more species. 5. The composition according to any one of claims 1 to 4 , wherein an N-long-chain acyl acidic amino acid di-salt is present, and the amount thereof is (A) N-long-chain acyl acidic amino acid mono-salt. On the other hand, the aqueous thickening gel composition is characterized in that the molar ratio is 0.25 times or less. 6. A composition according to any one of claims 1 to 5, and (A) N-long chain acyl acidic amino acid monosalt,
(B) An aqueous thickening gel-like composition characterized in that an amphipathic substance forms an aggregate in water. 7. The thickened gel-like composition according to any one of claims 1 to 6 , wherein the composition has a pH of 5.5 to 7. 8. claims 1-7 and thickening composition according to any one of the described, (D) a liquid oil-in-water emulsified composition characterized by comprising an oil. 9. The composition according to claim 8 , wherein (D)
Oil content is (D) / ((A) + (B) + (C)) = 1/99
The liquid oil-in-water emulsion composition is contained in the range of 80/20. 10. The composition of claims 8-9 ,
A liquid oil-in-water emulsion composition having a viscosity of 500 to 10,000 cps at 25 ° C.