JP3526330B2 - Skin cosmetics - Google Patents

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION The present invention is excellent in the effect of improving rough skin, particularly oily rough skin, and can adjust the texture of the skin.
Moreover, it relates to safe skin cosmetics.

[0002]

2. Description of the Related Art Rough skin is a skin trouble experienced by a large number of people, and is dealt with by cosmetics and the like. Generally, rough skin is dry, and it tends to occur on the cheeks and lips where sebum secretion tends to be inadequate, resulting in a dry, dry, and white powdery skin. It is known that such dry skin roughness is associated with a decrease in the amount of the water-soluble component NMF and intercellular lipid in the stratum corneum, especially the amount of ceramide. A method of externally replenishing, for example, a method of using a combination of ceramide and an α-hydroxy acid such as 2-ketooctanoic acid, glycolic acid or lactic acid (JP-A-6-157283) is effective.

On the other hand, in addition to such dry skin roughness, there is also a type of skin roughness that should be called oily skin roughness. The oily skin roughening mainly occurs in a portion where sebum secretion is active, has a large amount of sebum, becomes unclear in texture such as a skin groove and a cuticle, and becomes a skin condition accompanied by scale-like scaling. It is considered that sebum, bacteria, vitamin metabolism, etc. are involved in the occurrence of such oily skin roughness (seborrheic dermatitis), but details are unknown. In addition, even if you take the same treatment as for dry skin,
Not enough effect.

It is known that a vitamin D ₃ derivative is effective for oily rough skin (Japanese Patent Laid-Open No. 169711/1987).
No.) and Vitamin Ds have a problem of excess disease, and are not satisfactory in terms of safety and effect. Further, although it is known that hydroxy acid is effective against excess sebum secretion (Japanese Patent Laid-Open No. 6-192032), no effect on oily skin roughness has been known.

Accordingly, the present invention is to provide a skin cosmetic which is safe and has an excellent effect of improving greasy skin roughness.

[0006]

Under such circumstances, as a result of intensive studies by the present inventors, the use of a combination of a specific carboxylic acid and an amide derivative results in excellent skin safety and oily skin roughening improving effect. The inventors have found that a cosmetic can be obtained and completed the present invention.

That is, the present invention provides the following components (A) and (B): (A) General formula (1); R ^1- (CH ₂ ) _n -COOH ... (1) (wherein R ¹ is hydroxymethyl group, 1-hydroxyethyl group, 2-hydroxyethyl group, 1,2-dihydroxyethyl group, 1-hydroxypropyl group, 1-hydroxybutyl group, 1-hydroxypentyl group, 1-hydroxyhexyl group. Group, a 1-hydroxyheptyl group or a 1-hydroxy-1-methylethyl group, and n represents a number of 7 to 10), and a compound selected from salts, ester derivatives and amide derivatives thereof, (B) General formula (2)

[0008]

[Chemical 2]

[In the formula, R ² represents a straight-chain or branched saturated or unsaturated hydrocarbon group having 10 to 26 carbon atoms, and R ³ represents a straight-chain or branched saturated or unsaturated hydrocarbon group having 9 to 25 carbon atoms. Represents an unsaturated hydrocarbon group, Y and Z are each a hydrogen atom or-(CH
₂ ) _n -OH (n is a number of 1 to 3), A is a single bond or -O-CH _2- (where an oxygen atom is bonded to R ² )] The present invention provides a skin cosmetic containing.

The carboxylic acid as the component (A) used in the present invention is represented by the above general formula (1). In the formula,
R ¹ is a hydroxymethyl group, a 1-hydroxyethyl group,
2-hydroxyethyl group, 1,2-dihydroxyethyl group, 1-hydroxypropyl group, 1-hydroxybutyl group, 1-hydroxypentyl group, 1-hydroxyhexyl group, 1-hydroxyheptyl group or 1-hydroxy-
1-methylethyl group, especially from the terminal (ω-position) to ω-
A linear alkyl group having a hydroxyl group at the 6-position is preferred. Moreover, n shows the number of 7-10.

A specific combination of R ¹ and n is as follows: when n = 7, R ¹ is 1-hydroxypropyl group; when n = 8, R ¹ is hydroxymethyl group, 1-hydroxyethyl group. Or 1-hydroxy-1-methylethyl group; n
When R = 9, R ¹ is a hydroxymethyl group; n = 10
When R ¹ is a hydroxymethyl group or a 1-hydroxyheptyl group, R ¹ is a 1-hydroxyethyl group when n = 8; R ¹ when n = 9 It is preferably a hydroxymethyl group.

The component (A) may be a salt, ester derivative or amide derivative of such a carboxylic acid. Examples of carboxylic acid salts include alkali metal salts such as sodium salts and potassium salts; alkaline earth metal salts such as calcium salts; ammonium salts; alkylamine salts such as triethylamine salts; triethanolamine salts, triisopropanolamine salts and the like. Examples thereof include alkanolamine salts; amino acid salts such as lysine salts and arginine salts; guanidine salts; sugar amines such as glucosamine salts, and ammonium salts, alkanolamine salts and amino acid salts are particularly preferable. As the salts of these carboxylic acids, those which are salted by a known method in advance can be used, and
The carboxylic acid and the base may be added separately to form a salt in the composition.

Examples of the ester derivative of carboxylic acid include alkyl esters such as methyl and ethyl; branched alkyl esters such as 2-ethylhexyl; aryl esters containing an aromatic ring such as benzyl; glycerin, propylene glycol, polyethylene glycol and the like. Examples thereof include esters with polyhydric alcohols.

As the amide derivative of carboxylic acid, an amide obtained by a reaction with ammonia; an alkylamide obtained by a reaction with methylamine, ethylamine, propylamine, etc .; a reaction with monoethanolamine, diethanolamine, etc. Alkyl amides substituted by a hydroxyl group that can be obtained; amides obtained by reaction with amino acids such as glycine and phenylalanine.

As a preferable compound as the component (A), for example, 9-hydroxynonanoic acid (9-hydrox) is used.
nonanoic acid, 10-hydroxydecanoic acid (10-Hydroxydecanoic ac)
id) 10,11-dihydroxyundecanoic acid (1
0,11-Dihydroxyundecanoica
cid), 9-hydroxyundecanoic acid (9-Hydr
10-hydroxyundecanoic acid (10-Hydroxyundecanoi)
c acid), 10-hydroxyundecanoic acid sodium salt (Sodium 10-Hydroxyundec)
anoate), 10-hydroxy-10-methylundecanoic acid (10-Hydroxy-10-methyl)
undecanoic acid), 11-hydroxyundecanoic acid (11-Hydroxyundecano)
ic acid), sodium 11-hydroxyundecanoate (Sodium 11-hydroxyunde)
canoate), 11-hydroxyundecane amide (11-Hydroxyundecanamide),
Ethyl 11-hydroxyundecanoate (Ethyl 1
1-Hydroxyundecanoate), 12-
Hydroxydodecanoic acid (12-Hydroxydode
canoic acid), 13-hydroxytridecanoic acid (13-Hydroxytridecanoic
acid), 14-hydroxytetradecanoic acid (14-
Hydroxytetradecanoic aci
d), N- (2-hydroxyethyl) -11-hydroxyundecane amide [N- (2-Hydroxyetheth
yl) -11-hydroxyundecanamid
e], N- (11-hydroxyundecanoyl) -glycine [N- (11-hydroxyundecanoy
l) glycine], triisopropanolamine 9-hydroxyundecanoate (Triisopropan)
olamine9-hydroxyundecanoa
te), 10-hydroxyundecanoic acid triethanolamine (Triethanolamine 10-hy)
Droxyundecanoate, 10-hydroxyundecanoic acid arginine salt (Arginine 10)
-Hydroxyundecanoate, ammonium 10-hydroxyundecanoate (Ammonium
10-hydroxyundecanoate), 1
1-hydroxyundecanoic acid triethanolamine (T
riethanolamine 11-hydroxy
undecanoate), 11-hydroxyundecanoic acid arginine salt (Arginine 11-hydr)
oxyundecanoate), ammonium 11-hydroxyundecanoate (Ammonium 11-h
hydroxyundecanoate), 12-hydroxydodecanoic acid triethanolamine (Trietha)
nolamine 12-hydroxodeca
Noate), 12-hydroxystearic acid (12-
Hydroxysteric acid) and the like, and commercially available products can be used as they are.

As the component (A), the above-mentioned carboxylic acid,
In addition, one or more selected from salts, ester derivatives and amide derivatives thereof can be used, and it is preferable to add 0.001 to 50% by weight (hereinafter referred to simply as%) in the total composition, particularly 0.01-30%, further 0.1
It is preferable to mix it in an amount of 10% because the higher effect can be obtained and the feeling is good.

The amide derivative of the component (B) used in the present invention is represented by the above general formula (2). In the formula, R ² represents a linear or branched saturated or unsaturated hydrocarbon group having 10 to 26 carbon atoms, and specific examples thereof include
Decyl group, undecyl group, dodecyl group, tridecyl group,
Alkyl groups such as tetradecyl group, pentadecyl group, hexadecyl group, octadecyl group, octadecyl group, eicosyl group, docosyl group, tetracosyl group, pentacosyl group, hexacosyl group, 2-ethyloctyl group, 3-ethyloctyl group; oleyl group, linoleyl group, etc. Examples thereof include an alkenyl group; an alicyclic hydrocarbon group such as anthracenyl group; and an aromatic hydrocarbon group such as diphenylmethyl group and naphthyl group. Also, R ³
Represents a linear or branched saturated or unsaturated hydrocarbon group having 9 to 25 carbon atoms, and specific examples thereof include a nonyl group,
Examples thereof include alkyl groups such as 2-methyloctyl group; aromatic hydrocarbon groups such as mesityl group; and those having 25 carbon atoms among the above hydrocarbon groups. R ² has 1 carbon atom
An alkyl group having 2 to 18 is preferable, and an alkyl group having 9 to 17 carbon atoms is preferable as R ³ .

The amide derivative (2) is prepared by a known method [for example, Polish Journal of Chemistry (Pol. J. Chem.) 52 , 1059 (197).
8); ibid. 52 , 1283 (1978); JP-A-54-1.
No. 17421, No. 54-144308, No. 54-14
7937 gazette]. That is, it can be produced by acylating the compound (5) obtained from the glycidyl ether (3) and the alkanolamine (4) according to the reaction formula shown below, and then selectively hydrolyzing the ester group.

[0019]

[Chemical 3]

[Wherein R ² , R ³ , Y and Z have the same meanings as described above, Z'is an anion group obtained by removing a hydrogen atom from Z when Z is-(CH ₂ ) _n -OH. , And when Z is a hydrogen atom, it represents a single bond.]

Among these amide derivatives, particularly preferred are the following general formulas (2-a) and (2-b).
Is represented by.

[0022]

[Chemical 4]

[In the formula, R ² and R ³ have the same meanings as described above.]

In the present invention, the amide derivative of the component (B) can be used alone or in combination of two or more,
It is preferable to add 0.001 to 50% of the total composition,
It is particularly preferable to add 0.01 to 30%, more preferably 0.1 to 10%.

In the skin cosmetic of the present invention, it is preferable to add sterols in addition to the components (A) and (B) because the effects of the present invention can be further enhanced. Examples of such sterols include cholesterol; cholesterol fatty acid esters such as cholesterol isostearate and cholesterol palmitate; provitamin D
₃ , campesterol, stigmasteranol, stigmasterol, 5-dihydrocholesterol, α-spinasterol, paristerol, clionasterol, γ
-Sitosterol, stigmasterol, salgasterol, avenasterol, ergostanol, sitosterol, colpisterol, chondrilasterol, polyferrasterol, haliclonasterol, neospongosterol, fucosterol, aptostanol,
Ergostadienol, ergosterol, 22-dihydroergomaterol, brassicasterol, 24-methylenecholesterol, 5-dihydroergosterol, dehydroergosterol, fungisterol, cholestanol, coprostanol, dimosterol, 7
-Hetocholesterol, latosterol, 22-dehydrocholesterol, β-sitosterol, cholestatriene-3β-ol, coprostanol, cholestanol, ergostyrol, 7-dehydrocholesterol, 24-dehydrocholestrethan-3β-ol, Examples include equilenin, equilin, estrone, 17β-estradiol, androst-4-ene-3β, 17β-diol, dehydroepiandrosterone, and mixtures thereof.

Of these sterols, cholesterol, cholesterol isostearate, phytosterol, provitamin D ₃ , 5-dihydrocholesterol are preferred, and cholesterol and cholesterol isostearate are particularly preferred.

The sterols can be used alone or in combination of two or more, and 0.01 to 10% in the total composition.
It is preferably blended, in particular, 0.05 to 5%, more preferably 0.
It is preferable to add 1 to 2% because the feel is more excellent.

The skin cosmetic of the present invention further comprises oil, water,
It is possible to add desired components such as emulsification type, dispersion type, two-layer type, solubilization type, gel, etc. by adding components such as surfactants which are usually used in cosmetics, lotion, emulsion, cream, pack. Agents, foundations, etc. can be used.

As the oil component, for example, the general formula (6)

[0030]

[Chemical 5]

(Wherein ^one of Z ¹ and Z ² is R ⁵ -Y ^1- ,
The other represents a hydroxyl group or R ⁶ -Y-. R ⁴ , R ⁵ and R ⁶ represent a hydrocarbon group having a total carbon number of 13 to 40,
The hydrocarbon group may be substituted with a silicone residue. X and Y ^{1 each} represent an oxygen atom or a group —COO—) and a glycerin derivative represented by the formula and an oil agent usually used in cosmetics can be used. The oil agent is not particularly limited, and examples thereof include vegetable oils such as avocado oil, camellia oil, macadamia nut oil, olive oil and jojoba oil; beef tallow, lard,
Animal oils such as egg yolk fats; fatty acids such as oleic acid and isostearic acid; alcohols such as hexadecyl alcohol and oleyl alcohol; cetyl 2-ethylhexanoate, 2-ethylhexyl palmitate, 2-octyldodecyl myristate, di- Esters such as neopentyl glycol 2-ethylhexanoate, 2-octyldodecyl oleate, isopropyl myristate, glycerol triisostearate, di-paramethoxycinnamic acid-glyceryl mono-2-ethylhexanoate; dimethylpolysiloxane, Dimethylcyclopolysiloxane, methylphenylpolysiloxane, methylhydrogenpolysiloxane, octamethylcyclotetrasiloxane, octamethylcyclopentasiloxane, decamethylcyclopentasiloxane, fluid Ruffin, squalane, vaseline,
Examples include hydrocarbons such as solid paraffin. When blending these oils, 0.01 to 9 is added to the skin cosmetic.
It is preferable to add 9.99%, especially 0.1 to 99%
It is preferable to mix them.

Water can be used as a base together with ethanol and a water-soluble polyhydric alcohol. In particular, the use of a water-soluble polyhydric alcohol is preferable because it can provide further moisturizing ability. The water-soluble polyhydric alcohol contains two or more hydroxyl groups in the molecule, for example, ethylene glycol, propylene glycol, 1,3-butylene glycol, 1,4-butylene glycol, dipropylene glycol, glycerin and diglycerin. , Triglycerin, polyglycerin such as tetraglycerin, glucose, maltose, maltitol, sucrose, fructose, xylitol, sorbitol, maltotriose,
Examples thereof include threitol, erythritol, and starch-decomposing sugar reducing alcohol, and these can be used alone or in combination. When these water, ethanol, and water-soluble polyhydric alcohol are blended, the blending amount in the skin cosmetic can be appropriately set according to the dosage form, but the total amount thereof is usually 0.01 to 75%. It is preferable to mix such that the amount is 0.1 to 25%.

When the skin cosmetic of the present invention is emulsified or solubilized, it is preferable to add a surfactant. Examples of the surfactant include polyoxyethylene fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene sorbitol fatty acid ester, glycerin fatty acid ester, polyoxyethylene hydrogenated castor oil alkyl sulfate ester, polyoxyethylene alkyl sulfate ester, and fatty acid. Examples thereof include alkali metal salts, sorbitan fatty acid esters, glycerin fatty acid esters, and alkyl glyceryl ethers, and these can be used alone or in combination. When these surfactants are blended, 0.01 to 50% in skin cosmetics
It is preferable to mix it, especially 0.1 to 30% is preferable.

The skin cosmetic of the present invention may further contain silicones as an oil or a surfactant.
The silicones are not particularly limited as long as they are usually blended in cosmetics, and include, for example, octamethylpolysiloxane, tetradecamethylpolysiloxane, methylpolysiloxane, highly polymerized methylpolysiloxane, methylphenylpolysiloxane. In addition to siloxane, octamethylcyclotetrasiloxane, methyl polycyclosiloxane such as decamethylcyclopentasiloxane, trimethylsiloxysilicic acid, and further modified polyether modified silicone, polyether alkyl modified silicone, alkyl glyceryl ether modified silicone, etc. Silicone etc. can be mentioned. When blending these silicones, the blending amount in the skin cosmetic is such that dimethylpolysiloxane or the like is used as an oil component, polyether modified silicone or the like, or as a surfactant. Alternatively, the total amount with the surfactant may be adjusted so as to be the above amount.

The skin cosmetic of the present invention may be further blended with a powder to obtain a make-up cosmetic such as a foundation. Examples of the powder include mica, talc, sericite, kaolin, nylon powder, extender pigments such as polymethylsilsesquioxane, inorganic pigments such as pearl, red 202, red 226, yellow 4, and organic such as aluminum lake. Pigment, titanium oxide, zirconium oxide,
Inorganic powders such as iron oxide for protection against ultraviolet rays can be mentioned. These powders are treated with silicone such as methylhydrogenmethylpolysiloxane, trimethylsiloxysilicic acid and methylpolysiloxane, fluorine treatment with perfluoroalkyl phosphate ester, perfluoroalcohol and the like, amino acid treatment with N-acylglutamic acid and the like, Those treated with lecithin, metal soap, fatty acid, alkyl phosphate, etc. can also be used. When these powders are blended, the blending amount in the skin cosmetic can be appropriately set according to the dosage form, but it is usually preferable to blend 0.1 to 50%, and especially 1 to 30%. Preferably.

Further, the skin cosmetic of the present invention may contain various components usually contained in cosmetics, quasi-drugs, pharmaceuticals, etc. within a range not impairing the object of the present invention. Examples of such components include inorganic salts such as magnesium sulfate, potassium sulfate, sodium sulfate, magnesium chloride, sodium chloride; polyvinyl alcohol, carboxyvinyl polymer, carboxymethyl cellulose, gelatin, tragacanth gum, xanthan gum,
Examples thereof include viscosity adjusting agents such as hyaluronic acid, tuberose extract, agarose and sodium alginate; antiseptics such as parabens, ultraviolet absorbers, dyes, medicinal ingredients, and fragrances.

[0037]

EFFECTS OF THE INVENTION The skin cosmetic of the present invention is excellent in the effect of improving rough skin, particularly greasy rough skin, capable of adjusting the texture of the skin, and also excellent in safety.

[0038]

EXAMPLES Next, the present invention will be further described with reference to examples, but the present invention is not limited to these examples.

Example 1 A skin cosmetic having the composition shown in Table 1 was produced by a conventional method, and its skin roughening improving effect and skin texture adjusting effect were evaluated.
The results are shown in Table 2.

(Evaluation method) (1) Rough skin improving effect: Female panelist 1 aged 20 to 29
The skin cosmetics shown in Table 1 were applied to 2 persons for 6 weeks. The skin condition before and after application was measured with a direct skin analyzer (SCALAR) (x200 times), 10 each.
The resulting image was binarized according to the brightness, and the area of the high brightness area was quantified as the area of the whitened portion due to scaling. The evaluation was performed by the following formula as the degree of improvement from the area of the whitened portion before coating, and the average value thereof was shown by the following criteria.

[0041]

[Equation 1]

A: The degree of improvement is 50% or more. ◯: Improvement degree is 30 to 50%. Δ: The degree of improvement is 10 to 30%. X: The degree of improvement is less than 10%.

(2) Effect of adjusting skin texture: 20 to 29
Twelve year-old female panelists applied the control skin cosmetics shown in Table 1 to the right side of the face and the product of the present invention or the comparative product to the left side of the face for 6 weeks, and then replicated on the left and right cheeks (silicone resin). , Tosicon injection, manufactured by Toshiba Silicone Co., Ltd.). 3D-SKIN captures the replica surface into an image with a TV camera connected to a stereoscopic microscope
Using SCANNER (manufactured by Ichimaru Falcos Co., Ltd.), the shape analysis of the skin groove and crest was performed. The number of peaks and depressions of the uneven shape derived from the skin groove and crest is compared on the left and right cheeks, and it is effective when there is a clear increase in the number of peaks and a decrease in the peak interval, and there is a clear difference. If not, it was evaluated as invalid. The results are shown as the number of people evaluated.

[0044]

[Table 1]

[0045]

[Table 2]

Example 2 A lotion having the composition shown below was produced by a conventional method. The obtained lotion had an excellent effect of improving greasy skin roughness, was able to condition the texture of the skin, and was also good in safety.

[0047]

[Table 3] (Components) (%) 10-hydroxyundecanoic acid arginine salt 1.5 Amide derivative 2 ^{* 2} 0.6 Isostearyl alcohol 0.8 Polyoxyethylene methyl glucoside (20EO) 0.5 Polyethylene glycol 1000 4. 0 Glycerin 4.5 Glycine betaine 0.2 Sodium hydroxide 0.05 Methylparaben 0.1 Ethanol 5.0 Polyoxyethylene (40EO) hydrogenated castor oil 3.5 Water balance Perfume Micrometer 100.0 * 2: N - (3-hexadecyloxy-2-hydroxypropyl)-N-2-hydroxyethyl-hexadecanol cyanamide [general formula ^{(2), R 2 = -C} 16 H 33, R 3 = -C 15 H 31, A = -O-CH _2- , Y = H, Z = -CH ₂ CH ₂ OH)

Example 3 An emulsion having the composition shown below was produced by a conventional method. The obtained emulsion had an excellent effect of improving greasy skin roughness, was able to condition the texture of the skin, and was also good in safety.

[0049]

[Table 4] (Component) (%) 12-hydroxydodecanoic acid 1.5 Amide derivative 1 ^{* 1} 2.0 Amide derivative 2 ^{* 2} 0.5 Amide derivative 3 ^{* 3} 0.5 Polyoxyethylene (60EO) cured castor Oil 1.0 Sorbitan monostearate 0.5 Squalane 4.0 Stearic acid 1.0 Monocholesteryl alkenyl succinate 0.1 Glycerin 3.0 Propylene glycol 1.0 Methylparaben 0.3 Water balance Fragrance micrometer 100. 0 * 1: same as in Example 1 * 2: same as in Example 2 * 3: N- (3-tetradecyloxy-2-hydroxypropyl) -N-2-hydroxyethyl decanamide [general formula (2) Medium, R ² = -C ₁₄ H ₂₉ , R ³ = -C ₉ H ₁₉ , A = -O-CH _2- , Y = H, Z = -C H ₂ CH ₂ OH)

Example 4 A gel having the composition shown below was produced by a conventional method. The obtained gel had an excellent effect of improving greasy skin roughness, was able to condition the texture of the skin, and was also good in safety.

[0051]

[Table 5] (Components) (%) Amide derivative 2 ^{* 2} 0.4 11-Hydroxyundecanoic acid ethyl 1.2 Silicone KF96A (6cs) (manufactured by Shin-Etsu Chemical Co., Ltd.) 4.0 Polyoxyethylene-modified silicone SH3771E (Toray Dow Corning) 0.5 Polyoxyethylene (40EO) hydrogenated castor oil 0.2 Xanthan gum 0.1 Allantoin 0.1 Polyvinyl acrylate 0.2 KOH 0.05 Ethanol 12.0 Hydrogen phosphate 2Na 0.3 Succinic acid 0.15 Methylparaben 0.2 1,3-Propanediol 1.0 Water balance Perfume Micrometer 100.0 * 2: Same as Example 2.

Example 5 An emulsion having the composition shown below was produced by a conventional method. The obtained emulsion had an excellent effect of improving greasy skin roughness, was able to condition the texture of the skin, and was also good in safety.

[0053]

[Table 6] (Components) (%) N- (11-hydroxyundecanoyl) glycine 1.0 Amide derivative 2 ^{* 2} 2.0 Polyoxyethylene (20EO) sorbitan monostearate 1.5 Sorbitan monostearate 0 0.5 Cholesterol 0.5 Ethanol 8.0 Polyoxyethylene methyl glucoside (20EO) 1.0 Nylon powder 3.0 Glycerin 1.0 Zinc p-phenol sulfonate 0.4 Polyvinyl acrylate 0.2 Calcium hydroxide 0 .05 water balance fragrance micrometer 100.0 * 2: same as in Example 2

─────────────────────────────────────────────────── ─── Continuation of the front page (58) Fields surveyed (Int.Cl. ⁷ , DB name) A61K ^7/ 00-7/50

Claims (4)

(57) [Claims] 1. The following components (A) and (B): (A) General formula (1); R ^1- (CH ₂ ) _n -COOH ... (1) (wherein R ¹ is hydroxy. Methyl group, 1-hydroxyethyl group, 2-hydroxyethyl group, 1,2-dihydroxyethyl group, 1-hydroxypropyl group, 1-hydroxybutyl group, 1-hydroxypentyl group, 1-hydroxyhexyl group, 1- A carboxylic acid represented by a hydroxyheptyl group or a 1-hydroxy-1-methylethyl group, and n represents a number of 7 to 10, and a compound selected from a salt thereof, an ester derivative and an amide derivative, (B) general Formula (2) [In the formula, R ² represents a linear or branched saturated or unsaturated hydrocarbon group having 10 to 26 carbon atoms, and R ³ represents 9 to 2 carbon atoms.
5 represents a straight chain or branched chain saturated or unsaturated hydrocarbon group, Y and Z each represent a hydrogen atom or-(CH ₂ ) _n- OH (n represents a number of 1 to 3), and A Is a single bond or -O-CH _2-
(Provided that an oxygen atom is bonded to R ² )], which is a skin cosmetic containing an amide derivative. 2. The component (A) is 0.001 to 50% by weight,
The skin cosmetic according to claim 1, which contains 0.001 to 50 parts by weight of the component (B). 3. The method according to claim 1, further comprising sterols.
Or the skin cosmetic according to 2. 4. The skin cosmetic according to claim _3, wherein the sterol is selected from cholesterol, cholesterol isostearate, plant sterol, provitamin D ₃ and 5-dihydrocholesterol.