JP3568988B2 - Drug volatilization device and method for producing the same - Google Patents

Description

【００６９】
［実験２］
実験１と同様にして、表２に示す下層及び上層の配合により、参考例１，２，３の各芳香剤を製作し、各参考例についてそれぞれ、上層の厚みを１〜１５ｍｍの範囲で変化させ、芳香の持続性を測定し、その結果を表２に示す。
【００７０】
この参考例１〜３においては、それぞれ上層のモノマーとして、不飽和結合を一つ有するラウリルアクリレート、二つ有するジエチレングリコールジメタクリレート及び、四つ有するジトリメチロールプロパンテトラアクリレートを使用しており、上層のモノマー成分の不飽和結合の違いによる揮散性薬剤の揮散速度の差を調べるものである。
【００７１】
【表２】

【００７２】
以上の実験の結果から、次のことが理解できる。
すなわち図２において、各実施例及び比較例のグラフの傾斜角度は、単位期間当りの香料の減少量を表わすのであって、傾斜角度が大きいことは単位期間当り大量の香料が揮散して強い芳香を発し、傾斜角度が小さいときには香料の揮散速度が小さく芳香が弱いことを示している。
【００７３】
而して図２によれば、上層のない比較例１においては、初期の傾斜角度が極端に大きく、急速に香料が揮散し、強烈な芳香を発していることが判る。そして約１．５ケ月程度で香料の８０％が揮散し、それ以後は傾斜角度が小さくなり、揮散速度が小さく、ほとんど芳香を発していない。
【００７４】
従って比較例１の芳香剤では、使用の初期においては香料が大量に揮散し、激しい芳香を発してかえって不快感を生じる。そしてかかる激しい芳香が収まった後は、最早芳香を生じなくなってしまう。
【００７５】
これに対し実施例１，２，３によれば、初期の揮散速度は小さく芳香は穏やかであり、また期間が経過しても傾斜角度は殆ど変らず、揮散量が減少することはなく、長期間に亙って芳香が持続する。
【００７６】
比較的揮散速度が大きい実施例１でも６．５ケ月程度の持続性を有しており、また実施例２，３では８〜１０ケ月程度の持続性を有しているのであって、穏やかな芳香が長期間持続するのである。
【００７７】
また実施例６では上層に少量の香料を添加しているが、この例では実施例２〜５に較べて持続性が低下しており、上層に少量の揮散性薬剤を添加することにより全体の揮散速度を速める作用をすることが理解できる。しかしながら比較例３のように、上層に多量の香料を添加すると、揮散速度が速くなりすぎて、持続性が低下する。
【００７８】
また実験２の結果によれば、上層のゲル状樹脂におけるゲル基剤のモノマー成分が有する不飽和結合の数により、また上層の厚みにより、下層に含まれる香料の揮散速度に差が生じることが理解できる。
【００７９】
すなわち前記モノマー成分の不飽和結合が少いほど、また上層の厚みが小さいほど、香料の揮散速度が速く持続性が小さい。また前記モノマー成分の不飽和結合が多くなるに従い、また上層の厚みが大きなるほど、香料の揮散速度は遅くなり、持続性は大きくなる。
【００８０】
上層のモノマー成分が単一の不飽和結合を有する参考例１では持続性が短く、芳香を持続させるためには上層の厚みを厚くし、少くとも２ｍｍ以上とするのが好ましい。それに対し２以上の不飽和結合を有する参考例２，３では、上層の厚みが１ｍｍ程度でも持続性を十分に向上させることができるが、その半面上層を過度に厚くすると香料の揮散速度が遅くなるので、厚くても１０〜１２ｍｍ程度に抑えるのが適当である。
【図面の簡単な説明】
【図１】本発明の薬剤揮散具の中央縦断面図
【図２】薬剤揮散具における経時的な薬剤の揮散量を示すグラフ
【符号の説明】
１ 薬剤揮散具
２ 容器
３ ゲル状樹脂
４ 下層
５ 上層[0001]
[Industrial applications]
The present invention relates to a drug volatilization device for volatilizing a drug such as a fragrance, an animal attractant, or a repellent, and a method for producing the same.
[0002]
[Prior art]
2. Description of the Related Art Conventionally, a so-called fragrance has been known in which a fragrance is contained in a gel-like resin contained in a container, and the fragrance is gradually volatilized to fill a room or a car interior with a fragrance.
[0003]
[Problems to be solved by the invention]
These fragrances contain a fragrance in the gel resin and emit fragrance by volatilization of the fragrance from the surface of the gel resin, but it is difficult to control the volatilization rate of the fragrance. Was.
[0004]
Therefore, a large amount of the fragrance is volatilized in the early stage of use, and the fragrance may be too strong to be unpleasant. Further, since the volatilization speed is high, the fragrance volatilizes in a short period of time, and the effect is lost early.
[0005]
The present invention has been made in view of such circumstances, and has as its object to suppress the volatilization rate of a fragrance, prevent excessive fragrance from being generated, and maintain fragrance for a long period of time.
[0006]
The drug volatilization device of the present invention is not limited to the case where it is used as a so-called fragrance containing a fragrance in a gel resin, but contains a volatilizing drug such as a repellent or an attractant for animals. Is also included.
[0007]
[Means to solve the problem]
Thus, the first invention of the drug volatilization device of the present application is a drug volatilization device containing a gel resin containing a volatile drug in a container and exposing the gel resin to the outside air, wherein the gel resin is A lower layer containing a volatile agent and an upper layer containing no volatile agent or containing a smaller amount than the lower layer, wherein the gel-like resin is composed of an oligomer and a monomer having an unsaturated bond curable by light energy. The gel base is cured by light, the monomer component in the gel resin of the upper layer has a single unsaturated bond, and the thickness of the upper layer is 2 to 20 mm It is characterized by the following.
[0008]
The second invention of the drug volatilization device of the present application is a drug volatilization device in which a gel resin containing a volatile drug is contained in a container and the gel resin is exposed to the outside air, wherein the gel resin is volatilized. Gel comprising a lower layer containing a volatile agent and an upper layer containing no volatile agent or containing a smaller amount than the lower layer, wherein the gel-like resin is composed of an oligomer and a monomer having an unsaturated bond curable by light energy. The base is cured by light, and the monomer component in the gel resin of the upper layer has 2 to 6 unsaturated bonds, and the thickness of the upper layer is 1 to 12 mm. It is a feature.
[0009]
In the present invention, the content of the volatile agent in the gel resin of the lower layer is suitably from 5 to 50% by weight, and when the volatile agent is contained in the gel resin of the upper layer, The amount is suitably not more than 5% by weight.
[0010]
In addition, as the volatile agent in the present invention, a fragrance or an attractant or repellent for insects, birds, animals, and the like can be used.
[0011]
Further, in the drug volatilization device of the present invention, it is preferable that the container is made of a transparent material, and the upper layer and the lower layer are colored in different colors.
[0012]
Next, a first invention of a method for producing a drug volatilization device comprises an oligomer and a monomer having an unsaturated bond curable by light energy of 40 to 95% by weight, a volatile agent of 5 to 50% by weight, And an amount of a polymerization initiator and a sensitizer that can cure the monomer, and the mixture is poured into a container, cured by irradiating light to form a lower-layer gel resin, and then cured by light energy. An oligomer having an unsaturated bond and a monomer having a single unsaturated bond, and an amount of a polymerization initiator and a sensitizer capable of curing the oligomer and the monomer, and 5% by weight or less of a volatile agent Is added or not added, and this is injected onto the lower layer gel-like resin so as to have a thickness of 2 to 20 mm, and is irradiated with light and cured to form an upper layer gel-like resin. Things.
[0013]
Further, the second invention of the method for producing a drug volatilization device comprises 40 to 95% by weight of an oligomer and a monomer having an unsaturated bond curable by light energy, 5 to 50% by weight of a volatile drug, An amount of a polymerization initiator and a sensitizer capable of curing a monomer are mixed, and the mixture is poured into a container, irradiated with light, and cured to form a lower gel resin, and then cured by light energy. The resulting oligomer having an unsaturated bond and the monomer having 2 to 6 unsaturated bonds are mixed with an amount of a polymerization initiator and a sensitizer capable of curing the oligomer and the monomer, and 5% by weight or less of a volatile agent Is added or not added, and this is injected onto the lower layer gel resin so as to have a thickness of 1 to 12 mm, and is cured by irradiation with light to form an upper layer gel resin. Things.
[0014]
The drug volatilization device 1 of the present invention will be described with reference to the drawings. In FIG. 1, reference numeral 2 denotes a container, which is preferably made of a transparent material such as glass. The container 2 contains a gel-like resin 3, and the gel-like resin 3 is composed of two layers, a lower layer 4 and an upper layer 5.
[0015]
The upper opening of the container 2 is closed by a lid 7 having a large number of holes 6, and the gel resin 3 is in contact with the outside air through the holes 6 of the lid 7. Note that the lid 7 may be a mesh-shaped lid 7 instead of the structure in which the holes 6 are formed.
[0016]
The gel resin 3 in the container 2 needs to be exposed to the outside air, and the lid 7 may be any as long as it can maintain the state and prevent intrusion of dust and the like. Further, the lid 7 may not be used.
[0017]
As the gel resin 3, it is preferable to use, for both the lower layer 4 and the upper layer 5, a gel base composed of an oligomer and a monomer having an unsaturated bond which can be cured by light energy and cured by light.
[0018]
As the oligomer used as the gel base, a (meth) acrylic low polymer is suitable. For example, polyester (meth) acrylate, epoxy (meth) acrylate, urethane (meth) acrylate, alkyd resin (meth) acrylate , Spirane resin (meth) acrylate, silicone resin (meth) acrylate, and the like.
[0019]
The monomer is suitably a (meth) acrylate monomer, and a monomer having a single unsaturated bond or a monomer having 2 to 6 unsaturated bonds can be used.
[0020]
For example, monomers having a single unsaturated bond include (meth) acrylate esters of higher aliphatic alcohols such as lauryl (meth) acrylate and stearyl (meth) acrylate, and 2-ethylhexyl ( (Meth) acrylate, 2-hydroxypropyl (meth) acrylate, tetrahydrofurfuryl (meth) acrylate, 2-hydroxyethyl (meth) acrylate, phenoxyethyl (meth) acrylate, nonylphenoxyethyl (meth) acrylate, tetrahydrofurfuryloxyethyl Examples thereof include (meth) acrylate, tetrahydrofurfuryloxyhexanolide (meth) acrylate, and (meth) acrylate of ε-caprolactone adduct of 1,3-dioxane alcohol.
[0021]
The monomers having two unsaturated bonds include hexanediol di (meth) acrylate, neopentyl glycol di (meth) acrylate, diethylene glycol di (meth) acrylate, tripropylene glycol di (meth) acrylate, and polyethylene glycol di (meth) acrylate. ) Acrylate, neopentyl glycol di (meth) acrylate hydroxypivalate, di (meth) acrylate of neopentyl glycol adipate, di (meth) acrylate of 1,6-hexanediol diglycidyl ether, and the like.
[0022]
Further, as monomers having three or more unsaturated bonds, trimethylolpropane tri (meth) acrylate, dipentaerythritol propionate tri (meth) acrylate, ditrimethylolpropanetetra (meth) acrylate, dipentaerythritol tetrapropionate ( (Meth) acrylate, dipentaerythritol pentapropionate (meth) acrylate, dipentaerythritol hexa (meth) acrylate, trimethylolpropane ethylene oxide adduct tri (meth) acrylate, trimethylolpropane ethylene oxide or propylene oxide adduct (Meth) acrylate, penta (meth) acrylate of 1,3-dioxanepentanol, and ε-caprolactone adduct of dipentaerythritol Such as hexa (meth) acrylate.
[0023]
The mixing ratio between the oligomer and the monomer is not particularly limited, but generally, when the amount of the oligomer is large, the viscosity in an uncured state is increased, and bubbles are hardly removed at the time of filling in a container, and workability is deteriorated. In addition, the shrinkage ratio during curing increases, and the gel base material easily falls off from the container.
[0024]
Also, when the amount of the monomer is too large, it tends to be too soft to volatilize the fragrance quickly and hardly harden.
[0025]
Therefore, the ratio between the oligomer and the monomer should be adjusted according to the type of the oligomer and the monomer, in consideration of the fluidity of the uncured gel base material, workability, material and shape of the container, volatilization time of the fragrance, and the like. . Generally, the ratio of oligomer: monomer is suitably about 5:95 to 70:30, more preferably about 10:90 to 50:50.
[0026]
Further, a photopolymerization initiator or a photosensitizer is blended into the gel base material mainly composed of these oligomers and monomers so that they can be polymerized and gelled by light energy.
[0027]
Examples of the photopolymerization initiator or photosensitizer include benzyl dimethyl ketal, benzoin isobutyl ether, benzoin isopropyl ether, benzoin ethyl ether, benzoin methyl ether, 1-phenyl 1,2-propanedione-2- (o- Ethoxycarbonyl) oxime, 2,2-dimethoxy-2-phenylacetophenone, hydroxycyclohexylphenylketone, diethoxyacetophenone, 2-hydroxy-2-methyl-1-phenylpropan-1-one, benzophenone, p-chlorobenzophenone, chloro Thioxanthone, isopropylthioxanthone, 2-methylthioxanthone, halogen-substituted benzophenone, halogen-substituted alkyl-aryl ketone, 1-hydroxycyclohexylphenyl ketone, (1-6 -Cumene) (η-cyclopentadienyl) iron (1+) hexafluorophosphate (1-), 2-methyl- [4- (methylthio) phenyl] -2-morpholino-1-propanone, triethanolamine, Diethylethanolamine and the like can be mentioned.
[0028]
The amount of the photopolymerization initiator or photosensitizer to be added is usually about 3% by weight based on the gel base material.
[0029]
In the lower layer 4 and the upper layer 5 in the gel resin 3, the combination and the mixing ratio of the oligomer and the monomer may be the same or may be different.
[0030]
In the present invention, the lower layer 4 of the gel resin 3 contains a volatile agent such as a fragrance, and the upper layer 5 does not contain the volatile agent or the amount of the volatile agent even if it is included. Is limited to small amounts.
[0031]
As the volatile agent used in the present invention, a repellent or attractant for insects or beasts can be used in addition to a flavor.
[0032]
As the fragrance, steam-distilling musk musk, animal fragrance such as civet, castreum, ambergris, and the like, and roots, branches and leaves, flowers, flower buds, pericarp, seeds and the like of plants are steam-distilled. Natural fragrances such as vegetable fragrances obtained by the method, and extracted fragrances isolated from those natural fragrances, artificial fragrances such as synthetic fragrances obtained by chemical synthesis, and compounded fragrances obtained by appropriately mixing these. be able to.
[0033]
Examples of attractants for pests include methyl eugenol, 4- (p-acetoxyphenyl) -2-butanone, anethole, α-guaien, δ-guaien, β-brunessen, guayol, eugenol, methyl eugenol, stearic acid, elemol, Cascalic acid, palmitic acid, aldehydes, terpinyl acetate, borneol, nerolidol, palipranone-B, hinoki oil, lauan peel oil, cascarilla oil, altinyl alcohol, alkenyl aldehyde, alkenyl fatty acid ester, pheromone, furanone derivative , Vegetable alcohols, lactones and the like.
[0034]
Further, repellents for animals include the following. That is, for insects, dimethylphthalate, N, N-dimethyl-m-triamide, diethylcaprylate, benzaldehyde, diethyltriamide, 1,8-cineole, eugenol, cinnamyl alcohol, 3-hydroxyphenlandral, dibutyl Phthalate, naphthalene, β-naphthol dialdisulfide, citral, succinate, nonyl stil ketone, whiskey lactone, geranium, isobornyl thiocyanoaceteheth, dehydroacetic acid, safrole, d-limonene, salicylic acid, benzylformate, azalone, pine oil , Lemongrass oil, Japanese mint oil, sandalwood, spare mint oil, rose and the like.
[0035]
As repellents for birds, ethyl methylphenyl, glycidate, citonellal, bornyl acetate, octanal, methyl benzoate, limonene, citral, linalool, cashimiloride, γ-chloralose, diallyl disulfide, tetramethylthiuram disulfide, n-hexyl aldehyde , Decanal, heptanal, nonanal, undecanal, dodecanal, γ-nonalactone, γ-undecalactone, ethyl methylphenylglycidate and the like.
[0036]
Furthermore, for dogs and cats, 2,6-dimethyl-octadiene- (2,6) -al (8) (citral), O, O-diethyl S-2-ethylthioethyldithiophosphate (ETP), O, O-dimethyl S-2-isopropylthioethyldithiophosphate (MIP), cyclopentadecanone, cyclopentadecanolide, ambrettolide, cyclohexadecanolide, 1,1-oxahexadecanolide, ethylene Examples thereof include brush rate, 1,2-oxahexadecanolide, 1, O-oxahexadecanolide, cibetone, and muscone.
[0037]
The amount of these volatile agents in the lower layer 4 of the gel resin 3 varies depending on the type of the volatile agents and the purpose of use, but is preferably set in the range of 5 to 50% by weight.
[0038]
If the amount of the volatile drug is small, the efficacy of the drug is weak and the drug is not sustained. If the amount is too large, curing of the gel base material by light energy is often hindered, and sufficient hardness cannot be obtained. In addition, there is a large difference in physical properties from the upper layer, which causes a problem that the upper layer is warped. In addition, even if the drug is weak, a sufficient effect can be obtained if 50% is blended, so that using a more expensive drug increases the cost and is uneconomical.
[0039]
It is preferred that the upper layer 5 of the gel resin 3 does not contain a volatile agent. However, if the volatile agent incorporated in the lower layer 4 has poor volatility, a very small amount of the same type of agent is added to the upper layer 5. It is also preferable to mix them.
[0040]
The amount of the volatile agent in the upper layer 5 should be smaller than that in the lower layer 4, and should be kept at most 5% by weight or less. When a large amount of a volatile drug is blended in the upper layer 5, a route where the drug easily migrates after the drug is volatilized occurs, and the volatilization rate of the volatile drug blended in the lower layer 4 tends to increase through the route, which is preferable. Absent.
[0041]
The thickness of the gel-like resin 3 of the upper layer 5 in the present invention varies depending on the type and amount of the volatile chemical compounded, the purpose of use, and the like, but is preferably about 1 to 20 mm.
[0042]
However, when a substance having a single unsaturated bond is used as the monomer component of the gel base in the upper layer 5, the volatile chemical compounded in the lower layer 4 tends to easily migrate through the upper layer 5. Therefore, it is appropriate to slightly increase the thickness of the upper layer 5 to 2 to 20 mm.
[0043]
When the monomer component in the upper layer 5 has two or more unsaturated bonds, the migration speed of the volatile agent is low, so that the thickness of the upper layer 5 is preferably in the range of 1 to 12 mm.
[0044]
In the present invention, if the container 2 is a transparent body, the gel resin 3 can be appropriately colored to give a color to the appearance. Examples of the dyes used include azo dyes, anthraquinone dyes, indigoid dyes, phthalocyanine dyes, carbonium dyes, quinone imine dyes, methine dyes, quinoline dyes, nitro dyes, nitroso dyes, benzoquinone dyes, naphthoquinone dyes, naphthalimide dyes, and verinone Dyes and the like can be mentioned.
[0045]
Further, in this case, the lower layer 4 and the upper layer 5 of the gel resin 3 can be colored in different colors, so that a more varied appearance can be exhibited.
[0046]
Further, in the present invention, it is also preferable to add an ultraviolet absorber and a light stabilizer to the gel base.
[0047]
To manufacture the drug volatilization device 1 of the present invention, first, the gel base of the lower layer 4 obtained by mixing the oligomer and monomer, the volatilizable drug, the polymerization initiator and the sensitizer is poured into the container 2, The gel base is irradiated with light and cured to form the gel resin 3 of the lower layer 4.
[0048]
Next, the gel base of the upper layer 5 in which a small amount of a volatile agent is added or not added to the oligomer and the monomer, and further, a polymerization initiator and a sensitizer are mixed, is mixed with the gel resin 3 of the lower layer 4 in the container 2. The gel resin 3 of the upper layer 5 is formed by injecting light into the upper portion and irradiating the light to cure the resin.
[0049]
[Action]
In the present invention, the gel resin 3 is divided into a lower layer 4 and an upper layer 5, a volatile agent is mixed in the lower layer 4, and a volatile agent is not mixed in the upper layer 5. Since the amount is small, the volatile agent does not volatilize directly from the surface of the gel resin 3.
[0050]
The volatile chemicals contained in the lower layer 4 migrate to the upper layer 5 and gradually exude to the surface and volatilize. Therefore, the volatilization speed is reduced, and the volatile chemical does not volatilize in a short period of time. The effect lasts for a period.
[0051]
When a small amount of a volatile drug is blended in the upper layer 5, the volatile drug is volatilized to produce an effect of the drug in the early stage of use, and the volatile drug contained in the lower layer 4 is removed from the upper layer 5. It acts to induce migration to the surface and promotes volatilization of the volatile drug in the lower layer 4.
[0052]
【The invention's effect】
Therefore, according to the present invention, the gel resin 3 is divided into the lower layer 4 and the upper layer 5, and the volatile agent is mainly blended only in the lower layer 4. Therefore, the upper layer 5 suppresses the volatilization of the volatile agent, A large amount of the drug is not volatilized at the beginning of use, and the effect is not lost due to the volatilization of the drug at an early stage.
[0053]
In particular, in the case of conventional fragrances, when they are used, they are filled with strong fragrances and feel unpleasant, and when the excessive fragrance is calmed down, fragrance does not quickly occur and the effect is lost. there were.
[0054]
However, when the present invention is used as a fragrance, the rate of volatilization of the fragrance is low, so that an unduly strong fragrance does not cause discomfort and a gentle fragrance lasts for a long period of time, making it an ideal fragrance.
[0055]
Further, according to the present invention, by changing the thickness of the upper layer 5, the volatilization rate of the volatile drug can be adjusted. That is, by making the upper layer 5 thicker, the transfer of the volatile drug in the lower layer 4 can be suppressed, the volatilization speed can be reduced, and the duration of the effect can be extended. Conversely, if the upper layer 5 is made thinner, the volatilization rate of the volatile drug is increased, and the duration is shortened.
[0056]
The volatilization rate of the volatile agent can be adjusted by the number of unsaturated bonds of the monomer component in the gel base used for the gel resin 3 of the upper layer 5. That is, the smaller the number of unsaturated bonds in the monomer component, the faster the volatilization rate. If the number of unsaturated bonds increases, the volatilization rate decreases and the durability increases.
[0057]
Further, by blending a small amount of a volatile agent in the upper layer 5, the volatilization rate of the volatile agent can be increased.
[0058]
Therefore, by setting these conditions variously, it is possible to adjust the volatilization rate of the volatile drug and freely adjust the sustainability.
[0059]
【Example】
[Experiment 1]
Manufacture of air fresheners
For each Example and Comparative Example in Table 1, oligomers, monomers, and fragrances were blended according to the column for lower layer blending of each example, and thoroughly mixed to obtain a lower layer gel base. Then, into a glass container having an inner diameter of 60 mm and a depth of 35 mm, the lower layer gel base was filled with a thickness of 15 mm, and irradiated with ultraviolet rays for 20 seconds using a high-pressure mercury lamp under a temperature condition of 25 ° C. This was cured to form the gel resin 3 of the lower layer 4.
[0060]
Next, according to the column of the upper layer composition of each example in Table 1, oligomers and monomers and, in some cases, perfume were blended and thoroughly mixed to obtain an upper layer gel base. The lower layer 4 in the glass container is filled with the upper layer gel base having a thickness of 5 mm, and is irradiated with ultraviolet light under the same conditions as the lower layer to cure the gel base and remove the gel resin 3 of the upper layer 5. Formed.
[0061]
In Comparative Example 1, the gel resin 3 was not separated into an upper layer and a lower layer, and the upper layer was not formed.
[0062]
In addition, the oligomer in the lower layer composition and the upper layer composition of Table 1 was previously blended with 3% by weight of 2,2-dimethoxy-2-phenylacetophenone (Irgcure 651 manufactured by Ciba Geigy) as a photopolymerization initiator.
[0063]
performance test
Physical properties of gel resin
For each of the examples and comparative examples, the curability and hardness of the upper layer and the lower layer were examined, and the occurrence of warpage of the gel resin 3 after curing was observed.
[0064]
Reduction of gel resin
The fragrance using each of the gel resins of Example 1, Example 2, Example 3, and Comparative Example 1 was placed in a constant temperature room at 40 ° C., and its weight was measured over 300 days to evaporate the fragrance. Was measured and the results are shown in the graph of FIG.
[0065]
Aroma persistence
For each of the examples and comparative examples, the period until the weight corresponding to 80% of the blended fragrance was reduced was measured, and is shown in Table 1 in months.
[0066]
The volatilization rate of the volatile agent mixed in the gel-like resin is considered to be the life of the drug-evaporating device because the volatilization rate decreases rapidly after about 80% of the compounding amount evaporates. Can be.
[0067]
However, a long duration means that the volatilization rate of the volatile drug is slow, and it is not preferable that the duration is excessively large, and about 3 to 12 months is appropriate.
[0068]
[Table 1]

[0069]
[Experiment 2]
In the same manner as in Experiment 1, the fragrances of Reference Examples 1, 2, and 3 were produced by blending the lower layer and the upper layer shown in Table 2, and the thickness of the upper layer was changed in the range of 1 to 15 mm for each Reference Example. Then, the fragrance persistence was measured, and the results are shown in Table 2.
[0070]
In Reference Examples 1 to 3, lauryl acrylate having one unsaturated bond, diethylene glycol dimethacrylate having two, and ditrimethylolpropane tetraacrylate having four are used as monomers of the upper layer, respectively. The purpose of this study is to examine the difference in the rate of volatilization of volatile chemicals due to the difference in unsaturated bonds of components.
[0071]
[Table 2]

[0072]
The following can be understood from the results of the above experiments.
That is, in FIG. 2, the inclination angles of the graphs of the examples and the comparative examples represent the amount of perfume decrease per unit period. A large inclination angle indicates that a large amount of perfume is volatilized per unit period and a strong fragrance is emitted. When the inclination angle is small, it indicates that the volatilization rate of the fragrance is small and the fragrance is weak.
[0073]
According to FIG. 2, it can be seen that in Comparative Example 1 having no upper layer, the initial inclination angle was extremely large, the fragrance volatilized rapidly, and an intense fragrance was emitted. After about 1.5 months, 80% of the fragrance was volatilized, and thereafter, the inclination angle became small, the volatilization speed was small, and almost no fragrance was emitted.
[0074]
Therefore, in the fragrance of Comparative Example 1, the fragrance volatilizes in a large amount in the early stage of use and emits an intense fragrance, which in turn causes discomfort. After the intense scent has subsided, the scent no longer occurs.
[0075]
On the other hand, according to Examples 1, 2, and 3, the initial volatilization rate was small and the fragrance was gentle, and the inclination angle hardly changed even after the period had elapsed, and the volatilization amount did not decrease. Aroma persists over time.
[0076]
Example 1 having a relatively high volatilization rate also has a sustainability of about 6.5 months, and Examples 2 and 3 have a sustainability of about 8 to 10 months. The fragrance lasts for a long time.
[0077]
Also, in Example 6, a small amount of fragrance was added to the upper layer. However, in this example, the persistence was lower than in Examples 2 to 5, and by adding a small amount of volatile agent to the upper layer, the overall It can be understood that it acts to increase the volatilization speed. However, when a large amount of fragrance is added to the upper layer as in Comparative Example 3, the volatilization rate becomes too high, and the sustainability decreases.
[0078]
According to the results of Experiment 2, the volatilization rate of the fragrance contained in the lower layer may differ depending on the number of unsaturated bonds in the monomer component of the gel base in the gel resin in the upper layer and the thickness of the upper layer. It can be understood.
[0079]
That is, the smaller the unsaturated bond of the monomer component and the smaller the thickness of the upper layer, the higher the volatilization rate of the fragrance and the lower the persistence. Further, as the unsaturated bond of the monomer component increases and the thickness of the upper layer increases, the volatilization rate of the fragrance decreases, and the sustainability increases.
[0080]
In Reference Example 1 in which the monomer component of the upper layer has a single unsaturated bond, the durability is short, and in order to maintain the fragrance, it is preferable that the thickness of the upper layer be thick, and at least 2 mm or more. On the other hand, in Reference Examples 2 and 3 having two or more unsaturated bonds, the persistence can be sufficiently improved even when the thickness of the upper layer is about 1 mm. Therefore, it is appropriate to suppress the thickness to about 10 to 12 mm even if it is thick.
[Brief description of the drawings]
FIG. 1 is a central longitudinal sectional view of a drug vaporizer of the present invention.
FIG. 2 is a graph showing the amount of a drug volatilized over time in a drug volatilization device.
[Explanation of symbols]
1 Chemical vaporizer
2 containers
3 Gel resin
4 lower layer
5 Upper layer

Claims (7)

In a drug volatilization device containing a gel-like resin containing a volatile agent in a container and exposing the gel-like resin to the outside air, the gel-like resin does not contain a lower layer containing a volatile agent and a volatile agent. Or consists of two layers and an upper layer containing a smaller amount than the lower layer, wherein the gel-like resin is obtained by curing a gel base comprising an oligomer and a monomer having an unsaturated bond capable of being cured by light energy, Wherein the monomer component in the gel resin of the upper layer has a single unsaturated bond, and the thickness of the upper layer is 2 to 20 mm , In a drug volatilization device containing a gel-like resin containing a volatile drug in a container and exposing the gel-like resin to the outside air, the gel-like resin does not contain a volatile layer and a lower layer containing a volatile drug. Or consists of two layers and an upper layer containing a smaller amount than the lower layer, wherein the gel-like resin is obtained by curing a gel base comprising an oligomer and a monomer having an unsaturated bond capable of being cured by light energy, The monomer component in the gel resin of the upper layer has 2 to 6 unsaturated bonds, and the thickness of the upper layer is 1 to 12 mm A drug volatilization device characterized by being The content of the volatile agent in the lower layer gel-like resin is 5 to 50% by weight, and the content of the volatile agent in the upper layer gel-like resin is 0 to 5% by weight. The drug volatilization device according to claim 1 or 2. 3. The device according to claim 1 , wherein the volatile agent is a fragrance, an attractant or a repellent for insects, birds, animals, and the like. 4. 3. The chemical vaporizer according to claim 1 , wherein the container is made of a transparent material, and the upper layer and the lower layer are colored in different colors. 4. 40 to 95% by weight of an oligomer and a monomer having an unsaturated bond curable by light energy, 5 to 50% by weight of a volatile agent, and an amount of a polymerization initiator and a sensitizer capable of curing the oligomer and the monomer. And the mixture is poured into a container, and cured by irradiating light to form an underlying gel-like resin, and then an oligomer having an unsaturated bond which can be cured by light energy and a single unsaturated bond a monomer having a mixture of a polymerization initiator and a sensitizer in an amount capable of curing the oligomer and monomer, with or without the addition of 5 wt% or less of the volatile agent, the lower the gel it A method for producing a drug volatilization device , comprising injecting a resin to a thickness of 2 to 20 mm , irradiating light, and curing the resin to form an upper gel resin. 40 to 95% by weight of an oligomer or monomer having an unsaturated bond curable by light energy, 5 to 50% by weight of a volatile agent, and an amount of a polymerization initiator and a sensitizer capable of curing the oligomer and monomer. And the mixture is poured into a container, irradiated with light, and cured to form a lower-layer gel-like resin, and then an oligomer having an unsaturated bond which can be cured by light energy and 2 to 6 unsaturated monomers A monomer having a bond is mixed with an amount of a polymerization initiator and a sensitizer capable of curing the oligomer and the monomer, and 5% by weight or less of a volatile agent is added or not added, and this is mixed with the gel of the lower layer. 1 to 12 on resin mm A method for producing a drug volatilization device, comprising: injecting the mixture so as to have a thickness, and irradiating light to cure the mixture to form an upper gel resin.

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