JP3610340B2 - Functional food for suppressing blood sugar or blood pressure rise - Google Patents

Description

[0001]
BACKGROUND OF THE INVENTION
The present invention relates to a functional food for suppressing an increase in blood sugar or blood pressure.
[0002]
[Prior art]
Today, lifestyle-related diseases such as diabetes and hypertension are spreading mainly in developed countries in Europe and the United States, and Japan is no exception, and the rapid increase in lifestyle-related diseases associated with the westernization of the food environment has become apparent. As a result, the number of cases where malignant tumors and circulatory disorders of the brain and heart cause death is increasing in recent years.
[0003]
[Problems to be solved by the invention]
However, conventional medical drugs with high therapeutic effects for diabetes and hypertension are generally not suitable for long-term use due to the strong side effects and the problem of multiple toxicity due to multiple doses. .
[0004]
The present invention has been devised to solve such conventional problems, and its main purpose is to safely suppress the progression of diabetes or hypertension, which is the core of lifestyle-related diseases. To provide functional food.
[0005]
[Means for Solving the Problems]
In order to achieve such an object, in the present invention, a functional food for suppressing an increase in blood sugar or blood pressure is a kind of Citrusaceae and Citrus genus, native to the Philippines and southern China, and widely cultivated in Southeast Asia. The squeezed liquid of the whole fruit (fruit including a skin) of the dwarf citrus fruit which consists of the hybrid of the kumquat and the mandarin orange which are made to contain is characterized by the above-mentioned.
[0006]
DETAILED DESCRIPTION OF THE INVENTION
The present invention is described in detail below.
[0007]
The functional food containing squeezed juice from the whole fruit according to the present invention, that is, the fruit including the skin, is used for prevention of diseases associated with elevated blood sugar selected from the group consisting of insulin-dependent diabetes and non-insulin-dependent diabetes , Improvement, or treatment. The functional food containing the whole fruit juice according to the present invention is accompanied by an increase in blood pressure selected from the group consisting of essential hypertension and secondary hypertension such as renal hypertension, and borderline hypertension. It is also effective in preventing, improving, or treating diseases.
[0008]
Hereinafter, specific examples of the present invention will be described.
[0009]
The functional foods of the present invention are called Calamondin (international variety name), Shikikan (Shikitsu / Japanese name), Tangkinkan (Japanese name), Kalamansi (Philippine name), Shiki Tachibana (Chinese name). , scientific name is selected Citrus microcarpa Bunge, C. mitis Blanco , C. m ed ica var. limetta F.-V III, C. medurensis Lour, from Pseudofortunella madure ns is (louer.) these groups are Tseng Juice extracted from the whole fruit of citrus fruits (generally called calamancy in the Philippines, native to southern China and widely regarded as a hybrid of kumquats and citrus fruits widely grown in Southeast Asia) It is based on.
[0010]
By squeezing or centrifuging the whole fruit of the fertile citrus fruits, the juice juice can be easily obtained. Even if this undiluted undiluted solution is an undiluted undiluted solution, the undiluted undiluted juice or concentrated solution exhibits an effect of suppressing blood sugar or blood pressure increase. Therefore, for example, it is best to use 1 to 20% of the diluted solution as a drink in view of the fact that it can be easily ingested on a daily basis and the intake amount can be easily grasped.
[0011]
Further, the juice of whole fruit of the present invention can be obtained by spray-drying or freeze-drying the concentrated fruit juice to obtain a powder or a solid food. It can be easily ingested in various forms, such as being added to other foods.
[0012]
Then the verification results of the blood glucose increase inhibitory effect of the aqueous solution containing the pressed juice from whole-fruit dwarf citrus according to the invention (calamondin) will be described.
[0013]
Eight-week-old male spontaneously hyperglycemic (KKA ^y ) mice were subjected to blood glucose measurement and state observation while feeding solid chow during the pre-feeding period, and the average value of blood sugar at full and fasting was almost constant. 6 animals were divided into 2 groups. And each of the groups was distilled water for one day and an aqueous solution containing squeezed liquid from Calamancy as a test substance for the other, once a day for 28 days continuously, Changes in blood glucose levels were measured at the start of administration, on the 14th, 21st, and 28th days, at 10 am on the day of measurement, at 10 am, on the day of fasting, and at 10 am on the next day after fasting for 18 hours. The blood was collected from the orbital venous plexus and measured.
[0014]
The test substance was used in an amount equivalent to 200 mg / kg. The test results were expressed as mean values ± standard deviation, and student's-t was used for the significance test.
[0015]
As a result, as shown in FIGS. 1 and 2, the blood glucose level of the positive control group to which only distilled water was given, that is, the test substance was not given, was 366 mg / dl at the start of the test, 137 mg / dl at the fasting time. On the other hand, after 28 days, the diabetic blood glucose level was 436 mg / dl at the time of fullness and 140 mg / dl at the time of fasting, and the blood glucose level was on the rise.
[0016]
On the other hand, in the group administered with the test substance, the blood glucose level in the satiety shows a significant blood glucose rise inhibitory effect (311 mg / dl) with respect to the positive control group by 21 days after administration, and the blood glucose level in the fasting state is after the administration. By 14 days, a significant blood glucose elevation inhibitory effect was exhibited with respect to the positive control group (126 mg / dl), and thereafter the blood glucose elevation was significantly suppressed.
[0017]
Thus, the aqueous solution containing pressed juice from calamondin was demonstrated that a blood glucose elevation inhibitory effects on spontaneous hyperglycemia (KKA ^y) mice.
[0018]
Next, the verification result of the blood pressure increase inhibitory effect of the aqueous solution containing the squeezed liquid from the whole fruit of the fertile citrus fruits (calamancy) according to the present invention will also be described.
[0019]
For 8 weeks old, male spontaneously hypertensive (SHRSP) rats, blood pressure measurement and state observation were performed while feeding solid chow during the pre-feeding period, and 6 rats each so that the average value of systolic blood pressure was almost constant. Divided into 2 groups. And each of the groups was distilled water for one day and an aqueous solution containing squeezed liquid from Calamancy as a test substance for the other, once a day for 28 days continuously, The change in blood pressure was measured using the tail cuff method at the start of administration, on days 14, 21, and 28. The test substance was equivalent to 200 mg / kg, and the rats were kept in a holder kept at 38 ± 1 ° C. The test results were expressed as mean values ± standard deviation, and student's-t was used for the significance test.
[0020]
As a result, as shown in FIG. 3, the maximum blood pressure value of the positive control group that received only distilled water, that is, the test substance was not increased from 197 mmHg at the start of the test to 229 mmHg after 28 days and exhibited hypertension, In contrast, the group administered with the test substance showed a significant blood pressure increase inhibitory effect with respect to the positive control group by the 21st day after administration (208 mmHg), and the blood pressure increase was suppressed thereafter. .
[0021]
Based on the above, it was demonstrated that an aqueous solution containing the juice of test substance from calamancy has an effect of suppressing blood pressure elevation in spontaneously hypertensive (SHRSP) rats.
[0022]
【The invention's effect】
As described in detail above, according to the functional food of the present invention containing the juice from Karamanshi, it is possible to obtain an action of suppressing an increase in blood pressure as well as an action of suppressing an increase in blood sugar. . Therefore, according to the present invention, a great effect is obtained in suppressing the progression of the disease related to diabetes without causing side effects, and also effective in suppressing the progression of the disease related to hypertension without causing side effects. Is.
[Brief description of the drawings]
[Fig. 1] Blood glucose level fluctuation graph at full stomach [Fig. 2] Blood glucose level fluctuation graph at fasting [Fig. 3] Blood pressure level fluctuation graph

Claims (4)

It is a kind of Citrus family and Citrus genus. It contains squeezed juice of all fruit (including fruit skin) of fertile citrus fruits, which are native to the Philippines and southern China and are a mixture of kumquats and citrus fruits widely cultivated in Southeast Asia. A functional food for suppressing an increase in blood sugar. The citrus fruits are called Calamondin (international varieties), Shikikan (Shikitsu / Japanese name), Tangkinkan (Tokitsukan / Japanese name), Kalamansi (Philippine name), Shiki Tachibana (Chinese name). Citrus microcarpa Bunge, C. mitis Bla nc o, C. medica var. limetta F.-V III, C. medurensis Lour, Pseudofortunellamadurensis (louer.) is Tseng claims, characterized in that it is selected from these groups 2. A functional food for suppressing an increase in blood glucose according to 1. It is a kind of Citrus family and Citrus genus. It contains squeezed juice of all fruit (including fruit skin) of fertile citrus fruits, which are native to the Philippines and southern China and are a mixture of kumquats and citrus fruits widely cultivated in Southeast Asia. A functional food for suppressing an increase in blood pressure. The citrus fruits are called Calamondin (international varieties), Shikikan (Shikitsu / Japanese name), Tangkinkan (Tokitsukan / Japanese name), Kalamansi (Philippine name), Shiki Tachibana (Chinese name). Citrus microcarpa Bunge, C. mitis Bla nc o, C. medica var. limetta F.-V III, C. medurensis Lour, Pseudofortunellamadurensis (louer.) is Tseng claims, characterized in that it is selected from these groups 3. A functional food for suppressing an increase in blood pressure according to 3.

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