JP3615312B2 - Skin non-uniformity improving agent and cosmetic containing the same - Google Patents

Description

【００２７】
［実施例９］
実施例１の化粧水を用いて、くすみに悩む女性１群２０名を用いて、使用テストを行った。即ち、検体の化粧水を朝、晩１日２回２ヶ月間塗布してもらい、くすみの改善をアンケートで答えてもらった。対照群は実施例１の肌の不均一性改善剤１を水に置換したものを用い、比較群１は実施例１の肌の不均一性改善剤１をヒアルロン酸ナトリウムに置換したものを用い、比較群２は実施例１の肌の不均一性改善剤１をアスコルビン酸に置換したものを用いた。結果を表２に示す。これより本発明の化粧料はくすみの改善作用に優れることが判る。
【００２８】
【表２】

【００２９】
【発明の効果】
本発明によれば、肌の不均一性を改善し、くすみを改善する素材が提供できる。[0001]
BACKGROUND OF THE INVENTION
The present invention relates to a skin non-uniformity improving agent and a cosmetic containing the skin non-uniformity improving agent suitable for improving and preventing dullness caused by aging and the like.
[0002]
[Prior art]
Everyone has a desire to be more beautiful than others. For this reason, a mechanism for making it look beautiful has been studied, and various cosmetics based on the results have been developed. For example, cosmetics containing moisturizing ingredients such as sodium hyaluronate can improve the moisture retention of the skin and prevent the formation of wrinkles, and cosmetics containing ascorbic acid derivatives suppress the production of melanin. It can prevent the skin color from becoming black. Among such technological innovations, the so-called “dullness” phenomenon has not yet been clarified in its mechanism, and cosmetics that improve it have not been developed yet. The “dullness” here is a state where the skin color looks dark with redness decreasing, and there is no vivid feeling and it feels sagging, and it has already increased with increasing physical condition and age It is known and no one wants to be in this state. “Dullness” can be improved by treating with cosmetics developed so far, but the moisturizing cosmetics can improve or prevent wrinkles, or the whitening cosmetics can produce melanin. The effect is not so great as to suppress whiteness and maintain whiteness. This is said to be because "dullness" makes these physiological phenomena different from their types and causes.
[0003]
Under these circumstances, the present inventors have intensively studied for the cause of “dullness” and, as a result, have found that “dullness” is caused by non-uniformity of the fine structure of the skin. However, with regard to materials that improve the non-uniformity of the skin microstructure caused by such non-uniformity of skin, that is, non-uniformity of low luminance distribution, non-uniformity of melanin or non-uniformity of stratum corneum peeling, The current situation is not known at all.
[0004]
On the other hand, it has not been known at all that the following plant essence improves such skin non-uniformity and as a result, “dullness”.
Birch family birch (Betula pendula Roth.), Jujube daisou (Zizyphus jujuba Mill.), Rose family (Rosa multiflora Thun.), Hypericum family H. , Lamiaceae sage (Salvia officinalis L.), Button family peonies (Paeonia lactiflora Pall), Nettle family nettle (Urtica thumbergiana Sie.), Ultica diica L. ce s.
[0005]
[Problems to be solved by the invention]
The present invention has been made under such circumstances, and an object of the present invention is to provide a material that improves skin non-uniformity.
[0006]
[Means for Solving the Problems]
In view of this situation, the present inventors have intensively studied for the cause of “dullness” and, as a result, have found that skin non-uniformity is a major factor. Based on this finding, as a result of further research for substances that have the effect of improving skin non-uniformity, we found such effects in the following plant essences. As a result of further investigations, it was confirmed that cosmetics containing these compounds had a superior effect of improving “dullness”, and the present invention was completed. Hereinafter, the present invention will be described in detail with a focus on embodiments of the invention.
Birch family birch (Betula pendula Roth.), Jujube daisou (Zizyphus jujuba Mill.), Rose family (Rosa multiflora Thun.), Hypericum family H. , Lamiaceae sage (Salvia officinalis L.), Button family peonies (Paeonia lactiflora Pall), Nettle family nettle (Urtica thumbergiana Sie.), Ultica diica L. ce s.
[0007]
DETAILED DESCRIPTION OF THE INVENTION
(1) Skin heterogeneity improving agent of the present invention The skin heterogeneity improving agent of the present invention comprises one or more of the following plant essences. Here, the essence is the plant itself, a processed product obtained by drying, pulverizing or chopping a part or all of the plant, a part or all of the plant, or a solvent extract of those processed products or removing the solvent thereof. Is a general term for products and their fractions. The most preferable of these essences is a part or all of a plant body, or a solvent extract of a processed product thereof or a solvent-removed product thereof. The solvent used for the solvent extraction is preferably a polar solvent. Examples of the polar solvent include alcohols such as methanol and ethanol, esters such as ethyl acetate and methyl formate, nitriles such as acetonitrile, ethers such as diethyl ether and tetrahydrofuran. Preferred examples thereof include halogenated hydrocarbons such as chloroform and methylene chloride, ketones such as acetone and methyl ethyl ketone, polyhydric alcohols such as 1,3-butanediol and glycerin, and water. These may be used alone or in combination of two or more. Among these, a more preferable method is extraction using one or more selected from alcohols, polyhydric alcohols, and water. The extraction method may be performed in accordance with a normal method, for example, by adding a solvent of 1 to 10 times to a plant body or a processed product of the plant body, immersed for several days at room temperature, or for several hours at a temperature near the boiling point. Just do it. Stirring can be added as appropriate. The extract thus obtained may be used as it is, or the solvent may be removed by distillation under reduced pressure, or it may be used after being purified by silica gel column chromatography or liquid-liquid extraction. A production example is shown below.
Birch family birch (Betula pendula Roth.), Jujube daisou (Zizyphus jujuba Mill.), Rose family (Rosa multiflora Thun.), Hypericum family H. , Lamiaceae sage (Salvia officinalis L.), Button family peonies (Paeonia lactiflora Pall), Nettle family nettle (Urtica thumbergiana Sie.), Ultica diica L. ce s.
[0008]
[Production Example 1] 1 Kg of 1,3-butanediol is added to 1 kg of birch leaves, bark, and xylem, heated at 90 ° C. for 3 hours, insolubles are filtered off, and skin unevenness improving agent 1 is added. 0.8 kg was obtained.
[0009]
[Production Example 2] 10 l of 50% ethanol aqueous solution was added to 1 kg of birch leaves, bark, and xylem, refluxed for 2 hours, insoluble matter was filtered off, and the solvent was distilled off to remove 68 g of skin non-uniformity. 2 was obtained.
[0010]
[Production Example 3] To 1 kg of dry matter of Taisou, 10 l of 50% ethanol aqueous solution was added and refluxed for 2 hours. Insoluble matter was filtered off, the solvent was distilled off, and 430 g of skin non-uniformity improving agent 3 was obtained. Obtained.
[0011]
[Production Example 4] To 1 kg of dried fruits of Agetsu, 10 l of 50% ethanol aqueous solution was added, refluxed for 2 hours, insoluble matters were filtered off, the solvent was distilled off, and 180 g of skin non-uniformity improving agent 4 was obtained. Obtained.
[0012]
[Production Example 5] To 1 kg of hypericum herb, 10 l of 50% ethanol aqueous solution was added and refluxed for 2 hours. Insoluble matter was filtered off, and the solvent was distilled off to obtain 144 g of skin nonuniformity improving agent 5. .
[0013]
[Production Example 6] 10 L of 50% ethanol aqueous solution was added to 1 Kg of Hypericum perforatum grass, refluxed for 2 hours, insoluble matters were filtered off, and the solvent was distilled off to obtain 138 g of skin heterogeneity improver 6. It was.
[0014]
[Production Example 7] To 1 kg of peony root, 10 l of 50% ethanol aqueous solution was added and refluxed for 2 hours. Insoluble matter was filtered off, and the solvent was distilled off to obtain 251 g of skin nonuniformity improver 7.
[0015]
[Production Example 8] To 1 kg of nettle leaves, 10 l of 50% aqueous ethanol solution was added and refluxed for 2 hours. Insoluble matter was filtered off, and the solvent was distilled off to obtain 165 g of skin nonuniformity improving agent 8.
[0016]
[Production Example 9] 10 l of 50% ethanol was added to 1 kg of lotus rhizome and refluxed for 2 hours. Insoluble matter was filtered off and the solvent was distilled off to obtain 123 g of a skin non-uniformity improving agent 9.
[0017]
(2) Cosmetics of the present invention The cosmetics of the present invention are characterized by containing the above-described skin non-uniformity improving agent. The skin non-uniformity improving agent may contain only one species or two or more species. The types of the cosmetics of the present invention are not particularly limited as long as they are generally known cosmetics, for example, basic cosmetics such as creams and emulsions, makeup cosmetics such as foundations and lip colors. Preferred examples include hair cosmetics such as hair oils, hair tonics, shampoos, and rinses, beauty nails such as manicures and pedicures, cleaning agents such as body shampoos and soaps, and bath preparations such as bath bubbles and bath essences. This is because the skin non-uniformity improving agent of the present invention can improve not only the non-uniformity of the skin but also the non-uniformity of the human body tissue close to the skin, and thus can exhibit a preferable effect on hair and nails. . The preferable content of the skin non-uniformity improving agent in the cosmetic of the present invention is 0.001 to 10% by weight, more preferably 0.01 to 5% by weight, and further 0.05 to 1% by weight. preferable. The cosmetic of the present invention can contain optional components usually used in cosmetics in addition to these skin non-uniformity improving agents. Such optional components include hydrocarbons such as petrolatum and microcrystalline wax, esters such as jojoba oil and gallow, triglycerides such as beef tallow and olive oil, higher alcohols such as cetanol and oleyl alcohol, stearic acid Fatty acids such as oleic acid, polyhydric alcohols such as glycerin and 1,3-butanediol, nonionic surfactants, anionic surfactants, cationic surfactants, amphoteric surfactants, ethanol, carbopol, etc. Examples thereof include a sticky agent, an antiseptic, an ultraviolet absorber, an antioxidant, a pigment, and powders. The cosmetic of the present invention can be produced by treating these raw materials by a usual method. The cosmetic of the present invention has the effect of improving skin unevenness by improving skin unevenness. Therefore, the cosmetic of the present invention can make the person who makes up look younger than the actual age, and is also suitable as a cosmetic for preventing and improving aging.
[0018]
【Example】
[Example 1]
A lotion was prepared according to the following prescription. That is, the prescription ingredients were heated and dissolved at 80 ° C., stirred and cooled to obtain a lotion.
1,3-butanediol 5 parts by weight Glycerin 5 parts by weight Sodium hyaluronate 0.1 part by weight Methylparaben 0.1 part by weight Skin unevenness improver 1 0.1 part by weight Benzalkonium chloride 0.1 part by weight Phosphoric acid Sodium dihydrogen 0.1 parts by weight Ethanol 7 parts by weight POE (60) hydrogenated castor oil 0.1 parts by weight Perfume 0.1 parts by weight Water 82.3 parts by weight
[Example 2]
A lotion was prepared according to the following prescription. That is, the prescription ingredients were heated and dissolved at 80 ° C., stirred and cooled to obtain a lotion.
1,3-butanediol 5 parts by weight Glycerin 5 parts by weight Sodium hyaluronate 0.1 part by weight Methylparaben 0.1 part by weight Skin non-uniformity improving agent 2 0.1 part by weight Skin non-uniformity improving agent 3 0. 5 parts by weight benzalkonium chloride 0.1 part by weight sodium dihydrogen phosphate 0.1 part by weight ethanol 7 parts by weight POE (60) hydrogenated castor oil 0.1 part by weight perfume 0.1 part by weight water 81.8 parts by weight 0020]
[Example 3]
A lotion was prepared according to the following prescription. That is, the prescription ingredients were heated and dissolved at 80 ° C., stirred and cooled to obtain a lotion.
1,3-butanediol 5 parts by weight Glycerin 5 parts by weight Sodium chondroitin sulfate 0.1 part by weight Methylparaben 0.1 part by weight Skin unevenness improver 4 0.5 part by weight Benzalkonium chloride 0.1 part by weight Phosphoric acid Sodium dihydrogen 0.1 parts by weight Ethanol 7 parts by weight POE (60) hydrogenated castor oil 0.1 parts by weight Perfume 0.1 parts by weight Water 81.9 parts by weight
[Example 4]
A cream was prepared according to the following formulation. That is, the components i, b, and c were dissolved by heating at 80 ° C., kneaded well, diluted with b, and gradually added with emulsification. This was stirred and cooled to obtain a cream.
1,3-butanediol 5 parts by weight 70% aqueous solution of maltitol 10 parts by weight methylparaben 0.3 parts by weight butylparaben 0.1 part by weight triglycerin diisostearate 4 parts by weight liquid paraffin 7 parts by weight carnauba wax 3 Parts by weight dimethicone (1 cs) 4 parts by weight water 66.5 parts by weight skin non-uniformity improving agent 5 0.5 parts by weight skin non-uniformity improving agent 6 0.5 parts by weight sodium hyaluronate 0. 1 part by weight [0022]
[Example 5]
A foundation was prepared according to the following prescription. That is, the components (a), (b) and (c) were heated and dissolved at 80 ° C., kneaded well, (b) was added and diluted, (d) was added and dispersed, and (c) was gradually added to emulsify. This was stirred and cooled to obtain a foundation.
1,3-butanediol 5 parts by weight 70% aqueous solution of maltitol 10 parts by weight methylparaben 0.3 parts by weight butylparaben 0.1 part by weight triglycerin diisostearate 4 parts by weight liquid paraffin 7 parts by weight carnauba wax 3 Parts by weight dimethicone (1 c.s.) 4 parts by weight water 49 parts by weight skin non-uniformity improver 7 0.5 parts by weight sodium hyaluronate 0.1 parts by weight titanium dioxide 8 parts by weight talc 3 parts by weight sericite 2 parts by weight yellow iron oxide 3 parts by weight Bengala 2 parts by weight
[Example 6]
A hair tonic was prepared according to the following prescription. That is, the formulation components were weighed and solubilized with stirring at room temperature to obtain a hair tonic.
Ethinylestradiol 0.1 parts by weight Pepper tincture 0.1 parts by weight Menthol 0.1 parts by weight Skin heterogeneity improving agent 8 0.1 parts by weight Ethanol 40 parts by weight 1,3-butanediol 5 parts by weight Water 54.6 Weight part [0024]
[Example 7]
A bath preparation was prepared according to the following formulation. That is, the formulation components were weighed in a kneader and kneaded well to obtain a bath agent.
Sodium sulfate 70 parts by weight Lavender oil 10 parts by weight 1,3-butanediol 10 parts by weight Skin unevenness improver 9 1 part by weight Glycerin 9 parts by weight
[Example 8]
About the skin nonuniformity improving agents 1-9 of this invention, the skin nonuniformity improvement effect was measured. That is, the upper arms of 20 volunteers were irradiated twice with 0.8 MED ultraviolet B to create a non-uniform skin model. The specimen was administered for 4 weeks, and the morphology was observed after 5 weeks. The observation items of the morphology were the determination of the distribution of the low-luminance part, the determination of the melanin distribution, and the non-uniformity of stratum corneum peeling. The distribution of the low-brightness part is determined by observing the uniformity of the distribution of the low-brightness part when the skin is irradiated with light at an angle of 45 degrees and captured as an image by a CCD camera: score 2: extremely uniform, score 1: uniform, score 0 .5: Slightly uniform, rating 0: non-uniform and judged by naked eyes. The distribution of melanin was determined according to the following criteria by stripping the stratum corneum with cellophane tape, performing Fontana-Masson staining and hematoxylin-eosin staining, observing the melanin distribution for each cell under the microscope with the naked eye. Score 2: very uniform distribution, score 1: uniform distribution, 0.5: somewhat uniform distribution, 0: non-uniform distribution. At the same time, the method of peeling the stratum corneum was also determined according to the following criteria. Score 2: very good peeling method, rating 1: uniform peeling method, 0.5: somewhat uniform peeling method, 0: non-uniform peeling method The results are shown in Table 1 as average scores. The specimens were prepared by dissolving each skin heterogeneity improving agent at a concentration of 1% in a 50% ethanol aqueous solution, and the control was a 50% ethanol aqueous solution. In the case of no treatment, no ultraviolet irradiation was performed and nothing was administered. From this, it can be seen that the skin non-uniformity improving agent of the present invention is excellent in skin non-uniformity improving action.
[0026]
[Table 1]

[0027]
[Example 9]
Using the skin lotion of Example 1, a use test was conducted using 20 women per group suffering from dullness. That is, the skin lotion of the sample was applied twice a day for two months in the morning and evening, and the improvement of dullness was answered by a questionnaire. In the control group, the skin heterogeneity improving agent 1 of Example 1 was replaced with water, and in Comparative Group 1, the skin heterogeneity improving agent 1 of Example 1 was replaced with sodium hyaluronate. Comparative group 2 was obtained by substituting ascorbic acid for skin nonuniformity improving agent 1 of Example 1. The results are shown in Table 2. From this, it can be seen that the cosmetic of the present invention is excellent in dullness-improving action.
[0028]
[Table 2]

[0029]
【The invention's effect】
ADVANTAGE OF THE INVENTION According to this invention, the raw material which improves the nonuniformity of skin and improves dullness can be provided.

Claims (2)

Consisting only of the essence of any plant following, non-uniformity of the low-intensity distribution, improves the non-uniformity of the microstructure of the skin caused by non-uniformity of heterogeneity or desquamating melanin distribution, skin A microstructural heterogeneity improver;
Birch (Betula pendula Roth.), Jujuba Mill., Rose multiflora Thun., Hypericum erectum Thun., Hypericum pericum , Lamiaceae sage (Salvia officinalis L.), Button family peonies (Paeonia lactiflora Pall), Nettle family nettle (Urtica thunbergiana Sie. Or Urtica dioica L.), Lotus family (Nelumbonaceae Nelumbo). The skin microstructural heterogeneity improving agent according to claim 1, wherein the essence is an extract of a plant body with a polar solvent or a solvent removed product thereof.