JP3665899B2 - Deodorant made from Dokudami family - Google Patents

Description

[0001]
BACKGROUND OF THE INVENTION
The present invention relates to a deodorant that can be safely taken and can easily eliminate bad breath, has a strong deodorizing effect, and is easily available.
[0002]
[Prior art]
Prior art deodorants have various deodorants that have odor masking or complete odor elimination, but can be safely consumed and easily removed, making them easily available. Green tea was used as a deodorant.
[0003]
[Problems to be solved by the invention]
It is a conventional deodorant that can be safely taken and can easily eliminate bad breath, and as a readily available plant deodorant, there was green tea, but its deodorizing action was weak. For example, garlic In order to completely eliminate the bad breath, there was a problem that a large amount of green tea had to be taken.
[0004]
[Means for Solving the Problems]
In order to solve the above problems, it is known that the deodorant of the present invention, which is made from the Asteraceae plant, has a pharmacological action as a traditional Chinese medicine used as a safe medicine. Deodorant components exhibiting deodorant activity are separated and purified by a specified extraction and purification method using Saururaceae plants, which belong to the swordfish (scientific name: Houttuynia cordata Thunb) and Hangensho (scientific name: Saururus chinensis Baill). It is a thing.
[0005]
DETAILED DESCRIPTION OF THE INVENTION
An optimal embodiment of the deodorant of the present invention is a predetermined extraction and purification means using a living body consisting of the whole plant including raw leaves, flowers, stems and roots of Saururaceae plants or a dried body thereof as a raw material. This is a product obtained by separating and purifying a deodorant component compound having a specific specific physical property and chemical characteristics , which is secured by separating the deodorant component exhibiting deodorant activity .
[0006]
That is, using a slightly polar porous polymer, an extraction solution obtained by solvent extraction with water or alcohol using a living body consisting of the whole plant including fresh leaves, flowers, stems and roots of Saururaceae plants or a dried body thereof as a raw material. The substance is obtained by separating and purifying the diethyl ether eluate by thin layer chromatography after eluting with diethyl ether, eluting the components after washing with water, and having the following properties: Agent.
(1) Hydrophobic.
(2) Ether-soluble.
(3) It is a low molecule.
(4) Volatile.
[0007]
Further, as another embodiment of the deodorant of the present invention, a Saururaceae plant is used as a raw material, and it is secured by a predetermined cutting means from the raw material of a living body consisting of whole plants such as fresh leaves, flowers, stems and roots. is, can be processed generated and used for in vivo of small pieces is in solid form.
[0008]
In still another embodiment, the Saururaceae plant is used as a raw material, and the raw material of the living body composed of the whole plant such as fresh leaves, flowers, stems, roots, and the like is dried and ground into a powder form. It is ensured by pulverizing means, and can be processed and produced into a dry powder in solid form .
[0009]
Specific examples of the Saururaceae plant used as a raw material for the deodorant of the present invention are Dokudami (scientific name: Houttuynia cordata Thunb) and Hangensho (scientific name: Saururus chinensis Baill) .
[0010]
Dokudami (scientific name: Houttuynia cordata Thunb) is a perennial grass that grows under lowland forests and roadsides. The rhizomes are long and spread, the stalks are upright, the whole is soft, the leaves are alternating, there are large cocoon leaves, short spikes at the end of the stem, and many small flowers. Honshu: Widely distributed in Okinawa, China, Himalayas, and Southeast Asia. It has pharmacological action and is used as a traditional Chinese medicine. It is used for the treatment of antipyretic, detoxification, diuresis, eczema, swelling, insect bites, cuts, eyewash, anthelmintic, skin disease or gastrointestinal disease. The odor is decanoyl acetaldehyde. When it is dried, decanoyl acetaldehyde is oxidized and converted to methyl nonyl ketone, so the odor disappears.
[0011]
Hangensho (scientific name: Saururus chinensis Baill) is a perennial that grows in warm waters and wetlands. The rhizomes are long, the ground stems are upright, the whole is soft, the leaves are alternating, and they form long, narrow spikes at the ends of the stems, with many small flowers. It is distributed in the south of Kanto, Shikoku, Kyushu, Okinawa, China, and the Philippines. It has a pharmacological action and is used as a traditional Chinese medicine. It is used for antipyretic, detoxification, and beriberi.
[0012]
The raw material is a living body consisting of the whole plant including fresh leaves, flowers, stems and roots, but a dry powder consisting of the whole plant can also be used.
[0013]
In the deodorizer of the present invention , the predetermined extraction / purification means first immerses the raw material in the predetermined solvent in the solvent extraction step (S1), performs solvent extraction, uses distilled water as the solvent, Extraction can be performed from a living body or a dry state, but if an organic solvent such as methanol or acetone is used, the extraction efficiency can be increased, and a predetermined extraction solution containing the deodorant component is secured. Next, in the adsorption step (S2), a plurality of slightly polar porous polymer beads, which are gas chromatographic fillers, are adsorbed and collected, and in the next component elution step (S3), a plurality of the beads are collected. Is eluted with diethyl ether to obtain a diethyl ether eluate containing the deodorant component. The eluate is then used in a thin layer chromatographic purification step (S4). The deodorant component is separated and purified using a glass, the thin layer plate is coated with silica gel on a glass plate, the lower end portion of the thin layer plate is immersed in a developing solvent, and is placed vertically, and A horizontal line drawn at the height of the thin layer plate near the developing solvent liquid surface is determined, and the line from the original line to the vicinity of the upper end of the thin layer plate is divided into 10 equal parts. The diethyl ether eluate containing a deodorizing component is dropped, and the developing solvent is developed from the lower end of the thin layer plate toward the upper end. The deodorizing activity of the eluted component contained in each fraction is 9 / The strongest deodorant activity was obtained in 10 fractions (Rf = 0.9), and the deodorant component contained in the fractions was scraped off the silica gel of the same fraction in the filter paper adsorption step (S5), The deodorant component contained is eluted with diethyl ether, and the eluate is added dropwise to filter paper. After evaporation of the can also be ensured adsorbed adsorbed filter paper (3) the digestion odor component.
[0014]
By the way , the predetermined extraction and purification means can use a gas chromatographic purification step instead of the above-described thin layer chromatographic purification step (S4). Because it is volatile.
[0015]
Here, the specific physical properties and chemical characteristics of the deodorant component compound indicate the following items.
1: Solid at least at room temperature.
2: Soluble in organic solvents such as methanol and diethyl ether.
3: Low polarity compound.
4: Deodorant component compound collected and separated into 9/10 fractions (Rf = 0.9) in the thin-layer chromatographic purification step (S4).
[0016]
The deodorant made from the Asteraceae plant of the present invention is the grated garlic odor, bad breath after eating garlic, fecal odor, diaper malodor, garbage odor, and fish odor. Compared to green tea, which is a deodorant of the prior art, it has a significant deodorizing effect.
[0017]
The deodorant made from the Asteraceae plant of the present invention is close, easily available at a low cost, can be taken harmlessly to the human body, has safety, and its deodorizing effect is It is not an odor masking action, but a complete odor elimination action, and has a deodorizing action about 50 times or more than the deodorizing effect of green tea as a conventional deodorant.
[0018]
The deodorant made from the Asteraceae plant of the present invention has the effect of safely deodorizing the foul odor of the refrigerator for a predetermined period by using a predetermined amount.
[0019]
The deodorant made from the Asteraceae plant of the present invention has a function of completely deodorizing bad breath such as alveolar pyorrhea for a predetermined time.
[0020]
The deodorant made from the Asteraceae plant of the present invention has a significant deodorizing action against odor, foot odor, and other body odors.
[0021]
The deodorant made from the Asteraceae plant of the present invention has an action of eliminating various bad breath by eating a deodorized ingredient hardened with gelatin and made into a confectionery such as gummy.
[0022]
【Example】
Embodiments of the present invention will be described below with reference to the accompanying drawings based on experimental facts. Here, FIG. 1 shows details of the sample classification in the example deodorant, and shows details of Samples 1, 2, 3 and a comparative sample. FIG. 2 is a process flow diagram relating to extraction and purification of sample 3 which is an example deodorant. FIG. 3 is an explanatory diagram showing the deodorizing effect evaluation criteria used in the evaluation examples of the example deodorants. FIG. 4 is an explanatory diagram showing a deodorant evaluation for bad breath after a grated garlic meal, which is Evaluation Example 1 of the Example deodorant. FIG. 5 is explanatory drawing which shows the deodorization evaluation to the garbage odor which is the evaluation example 2 of an Example deodorizer. FIG. 6 is an explanatory view showing the deodorization evaluation for fish odor, which is evaluation example 3 of the example deodorant.
[0023]
As shown in FIG. 1, the use form of the example deodorant of the sample 1 is a raw material (1), which is a scorpion belonging to the family of Saururaceae (scientific name: Houttuynia cordata Thunb), and from the raw material of its fresh leaves , It consists of small leaves of raw leaves with a width of about several millimeters secured by a predetermined cutting means.
[0024]
In addition, as shown in Fig. 1 , the use of the deodorant of Example 2 in Sample 2 was made from raw leaves, flowers, and stems, using as a raw material (1) the dough dam (Saunauraceae) plant (scientific name: Houttuynia cordata Thunb). The raw material of the living body consisting of the whole plant such as roots is dried and pulverized into a powder form, and is made of a dry powder having a diameter of about 0.1-2 mm secured by a predetermined dry pulverization means .
[0025]
In addition, as shown in Fig. 1 , the use of the deodorant in Example 3 of Sample 3 was made from raw leaves, flowers, stems, using as a raw material (1) dodami (Houttuynia cordata Thunb) belonging to the Saururaceae plant. , Deodorant components exhibiting deodorant activity are separated and secured from the raw material of the whole plant, such as roots, by specific extraction and purification means, and adsorbed to filter paper having specific physical properties and chemical characteristics It can be secured as a deodorant component compound .
[0026]
In order to evaluate the deodorizing effect of Sample 1, Sample 2 and Sample 3 described above , as shown in FIG. 1, comparative samples of comparative examples according to the prior art were simultaneously evaluated, and the deodorizing effect was compared. As the comparative sample, a green tea dry powder containing a green tea flavonoid exhibiting deodorant activity, which is widely known from the prior art, was used.
[0027]
Here, a predetermined extraction and purification method will be described for the deodorant of Sample 3 which is an optimal embodiment of the present invention. As shown in FIG. 2, first, in the solvent extraction step (S1), the raw material (1) was immersed in a predetermined solvent to perform solvent extraction. The deodorizing component of the raw material can be extracted from the living body and the dried state of the raw material with the solvent of distilled water. However, when an organic solvent such as methanol or acetone is used, the extraction efficiency of the extraction solution (2) is increased. In the case of distilled water, extraction for 20 hours was about 50% by weight for biological raw materials and about 30-40% by weight for dry raw materials, but extraction efficiency of 80% by weight or more was obtained for methanol. In this way, the predetermined extraction solution (2) containing the deodorant component was secured.
[0028]
Next , the extraction solution (2) adsorbs and collects the deodorant component in the adsorption step (S2) using a plurality of micropolar porous polymer beads based on Ethylvinilbenzene and Divinilbenzene, which are gas chromatographic packing materials. In the next component elution step (S3), the plurality of beads are first washed well with distilled water and eluted with diethyl ether to obtain a diethyl ether eluate containing the concentrated deodorant component.
[0029]
Next, in the thin layer chromatographic purification step (S4), the deodorized component is separated and purified from the diethyl ether eluate using a thin layer plate. The thin layer plate is coated with silica gel on a glass plate (20 cm square shape), and the lower end of the thin layer plate is immersed in a developing solvent (volume ratio: pentane: diethyl ether = 8: 2), and vertically Set a horizontal line drawn at a height of about 2 cm from the developing solvent liquid level of the thin layer plate, and divide the original line to the vicinity of the upper end of the thin layer plate into 10 equal parts. The diethyl ether eluate containing the deodorant component is dropped on the original line. The developing solvent develops by capillarity from the lower end to the upper end of the thin layer plate, and the deodorizing component on the original line also develops upward due to its affinity. When the deodorizing activity of the eluted component contained in each fraction was examined in a predetermined evaluation example, it was 9/1 one lower than the upper end of the solvent development (10/10 fraction, ie, Rf = 1.0). The strongest deodorizing activity was obtained in 10 fractions (Rf = 0.9).
[0030]
Deodorant component contained in silica gel of the 9/10 fraction (Rf = 0.9) is then in filter paper adsorption step (S5), scraping the same fractions of silica gel, the digested odor component containing After elution with diethyl ether, the diethyl ether eluate was dropped onto a filter paper (2 cm × 4 cm) to volatilize diethyl ether, and an adsorption filter paper (3) adsorbing the deodorant component was secured.
[0031]
Here, the specific physical properties and chemical characteristics of the deodorant component compound of the sample 3 of the example deodorant are as follows, as is clear from the chemical properties in the deodorant component extraction and purification process by the extraction and purification means. Indicated.
1: Solid at least at room temperature (15-20 ° C).
2: Soluble in organic solvents such as methanol and diethyl ether. [That is, the above-mentioned property (1) hydrophobicity and property (2) ether solubility. ]
3: Low polarity compound. This low-polarity compound characteristic can be seen from a phenomenon that can be developed and collected up to a high position of the 9/10 fraction (Rf = 0.9) in the thin-layer chromatographic purification step (S4). [In other words, the above-mentioned property (3) is a low molecule. ]
4: A deodorant component compound exhibiting the strongest deodorant activity that is collected and separated into 9/10 fractions (Rf = 0.9) in the thin-layer chromatographic purification step (S4). [That is, the above-mentioned property (4) Volatility. ]
[0032]
In order to evaluate the deodorizing effect of Sample 1, Sample 2 and Sample 3 of the embodiment of the present invention, the comparative sample of the comparative example according to the prior art is evaluated at the same time. As shown in Fig. 4, an evaluation was performed based on the evaluation score corresponding to the evaluation content described in the deodorant effect evaluation criteria, and an integer obtained by rounding the average value was adopted as the evaluation result.
[0033]
Sample 1, Sample 2, Sample 3, and Comparative Example of Comparative Example 1 of the embodiment of the present invention, as shown in FIG. 4, are for the purpose of evaluating the deodorization of bad breath after grated garlic food. Suppose that there are four 21-year-old men and drink 100 ml (about 85 ° C.) of consomme (0.5 g solid) soup with 5 g of garlic. 30 minutes later, eight evaluators (a total of eight males and four females from 21 to 25 years old) exhale strongly at a position 20 cm away directly from the subject's mouth. After sniffing and memorizing the intensity of garlic odor contained in exhaled breath, the subject person was extracted and purified by means of sample 1: 1 g of docami leaves 1 g, sample 2: 1 g of dokudami dry powder, sample 3: 2 g of dokudami dry powder, Extracted and purified adsorbent filter paper (3) adsorbing deodorant components and comparison sample: 1 g of green tea powder was taken, and 30 minutes later, the evaluator sniffs the breath of the subject again, and garlic of dokudami The deodorizing effect on odor was evaluated. As shown in Evaluation Example 1 in FIG. 4, Sample 1, Sample 2, and Sample 3 using dokudami as a raw material (1) showed a significant deodorizing effect as compared with the comparative sample of the prior art: green tea powder.
[0034]
Sample 1 of the embodiment of the present invention, sample 2, sample 3, and comparative sample evaluation example 2 of the comparative example, as shown in FIG. Extraction and purification by means of extraction and purification from sample 1: 0.5 g of dokudami fresh leaf small pieces, sample 2: 2 g of dried dokudami powder, sample 3: 2 g of dried dokudami powder The adsorbent filter paper (3) adsorbing the deodorant component and the comparative sample: 2 g of green tea powder were added, and as described above, eight evaluators smelled the odor and evaluated the deodorizing effect. As shown in Evaluation Example 2 of FIG. 5, Sample 1, Sample 2, and Sample 3 using dokudami as a raw material (1) showed a significant deodorizing effect as compared with the comparative sample of the prior art: green tea powder.
[0035]
Sample 1, Sample 2, Sample 3, and Comparative Sample Evaluation Example 3 of the embodiment of the present invention were crushed, raw for the purpose of deodorizing fish odor as shown in FIG. 5 g of cocoon was collected in a 100 ml beaker, sample 1: 0.1 g of fresh leaf leaf, sample 2: 1 g of dried dokudami powder, sample 3: 2 g of dried dokudami powder, extracted and purified by adsorbing means, adsorbed deodorant components Adsorbed filter paper (3) and comparative sample: 1 g of green tea powder was added, and as described above, eight evaluators sniffed and evaluated the deodorizing effect. As shown in Evaluation Example 3 in FIG. 6, Sample 1, Sample 2 and Sample 3 using dokudami as a raw material (1) showed a significant deodorizing effect as compared with the comparative sample of the prior art: green tea powder.
[0036]
Sample 2 of the example of the present invention and Comparative Example 4 of the comparative sample were evaluated for the purpose of evaluating the deodorizing effect ratio of the sample 2 and the comparative sample, and 1 g of grated garlic was placed in a 100 ml beaker. Dry powder and comparative sample: Green tea powder, 0.1 mg to 500 mg, added in 6 different weights, garlic odor 30 minutes after addition, 8 evaluators sniff the odor, deodorizing effect evaluated. According to the evaluation of the deodorizing effect ratio, the weight of the comparative sample: green tea powder was 500 mg, which gave the same deodorizing effect corresponding to 10 mg of the dried sample powder 10 mg. Therefore, the deodorizing effect of Sample 2: Dokudami Dry Powder was about 50 times or more than the deodorizing effect of Comparative Sample: Green Tea Powder.
[0037]
【The invention's effect】
The present invention is carried out in the form as described above, and has the following effects.
[0038]
The deodorant made from the Asteraceae plant of the present invention is familiar, easily available at a low cost, can be safely used without harm to the human body, and its deodorizing effect is not an odor masking action, It has a complete odor elimination effect and has a deodorizing effect that is more than tens of times the deodorizing effect of green tea, which is a conventional deodorant.
[0039]
The deodorant made from the Asteraceae plant of the present invention has a wide variety of deodorants such as grated garlic odor, bad breath after eating garlic, fecal odor, diaper odor, garbage odor, and fish odor. It has a significant deodorizing effect.
[0040]
The deodorant made from the Asteraceae plant of the present invention has the effect of safely deodorizing the foul odor of the refrigerator for a predetermined period by using a predetermined amount.
[0041]
The deodorant made from the Asteraceae plant of the present invention has an effect of completely deodorizing bad breath such as alveolar pus leakage for a predetermined time.
[0042]
The deodorant made from the Asteraceae plant of the present invention has a significant deodorizing effect on the odor, foot odor and other body odors.
[0043]
The deodorant made from the Asteraceae plant of the present invention has an effect of eliminating various bad breaths by eating deodorized ingredients hardened with gelatin and made into a candy-like form such as gummi.
[Brief description of the drawings]
FIG. 1 is an explanatory diagram of sample classification in an example deodorant and shows details of samples 1, 2, 3 and a comparative sample.
FIG. 2 is a process flow chart relating to extraction and purification of sample 3 which is an example deodorant.
FIG. 3 is an explanatory diagram showing deodorant effect evaluation criteria used in an evaluation example of an example deodorant.
FIG. 4 is an explanatory view showing evaluation of deodorization to bad breath after eating grated garlic, which is evaluation example 1 of an example deodorant.
FIG. 5 is an explanatory diagram showing evaluation of deodorization of garbage odor, which is an evaluation example 2 of an example deodorant.
FIG. 6 is an explanatory diagram showing evaluation of deodorization to fish odor, which is evaluation example 3 of the deodorant in Example.
[Explanation of symbols]
1 Raw material 2 Extraction solution 3 Adsorption filter paper

Claims (1)

Saururaceae Using a slightly polar porous polymer to adsorb an extraction solution obtained by solvent extraction with water or alcohol, using as a raw material a living body consisting of the whole plant , including the raw leaves, flowers, stems and roots of the plant, or its dried body. A deodorant, which is a substance obtained by concentrating, washing with water, eluting components with diethyl ether, and separating and purifying the diethyl ether eluate by thin layer chromatography, having the following properties.
(1) Hydrophobic.
(2) Ether-soluble.
(3) It is a low molecule.
(4) Volatile.

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