JP3763322B2 - Method for producing flexible intraocular lens - Google Patents

Description

【００４６】
モノマー混合物を注入後、成形型の下型３を図示していない上型により密閉し、窒素圧２．０ｋｇ／ｃｍ²、温度１１０℃で２時間加熱重合を行ない、得られた重合物を成形型から離型して、図４に示すように、ワイヤ状部材５ａ，５ｂが埋入されている軟性光学部６を得た。
【００４７】
次に軟性光学部６からワイヤ状部材５ａ，５ｂを抜き取り、図５に示すように、光学部６を貫通する支持部孔７ａ，７ｂを有する軟性光学部６を得た。
【００４８】
次にＰＭＭＡ製フィラメントを熱成形することによって得た支持部８ａ，８ｂを支持部孔７ａ，７ｂの入口側から挿入し、支持部８ａ，８ｂの先端を支持部孔７ａ，７ｂの出口側からはみ出させた。
【００４９】
次に支持部孔７ａ，７ｂの出口からはみ出した支持部８ａ，８ｂの先端部を、光学部−支持部接合用プレポリマー（メチルメタクリレートモノマーに重合開始剤を添加し、温度８０℃で２〜３時間反応させたもの）の浴に接触させ、毛管現象によりプレポリマーを支持部孔７ａ，７ｂ内へ侵入させた。
【００５０】
支持部孔７ａ，７ｂ内にプレポリマーが侵入した後、約８０℃の温度中に２４時間静置して、プレポリマーを重合させ、光学部と支持部の接合を行なった。
【００５１】
このようにして図６に示すように、光学部６内の支持部孔７ａ，７ｂに支持部８ａ，８ｂが挿入され、光学部６と強固に接合されている軟性眼内レンズが得られた。この軟性眼内レンズは、これをガラスビーズと研磨剤と水の入ったボトルに入れバレル研磨を５日間行なった。
【００５２】
このようにして、光学部が、該光学部を貫通して設けられた支持部孔を有し、該支持部孔に支持部の先端部が挿入固定されている眼内レンズであって、支持部の先端部が、光学部の外周面と共に楕円形状を形成するように湾曲状に配置された眼内レンズが得られた。
【００５３】
本実施例で得られた軟性眼内レンズは、光学部に支持部材料の先端が強固に接合されており、光学部と支持部との接合強度を上記引張試験により求めたところ約５０ｇであった。
【００５４】
なお、本実施例において光学部の外周面と支持部の先端部とによって形成される楕円形状は図６に示すように中間部が比較的に薄い偏平形状であるが、中間部がこれよりも厚い楕円形状であってもよい。楕円形状は、眼内レンズ製造時の支持部材料の挿入性、眼内レンズにおける支持部と光学部との接合性などを考慮して適宜決定される。
【００５５】
（実施例２）
軟性光学部用モノマー混合物として、

からなるポリジメチルシリコーン系モノマー混合物を用い、重合を恒温槽中で８０℃、４８時間行なった以外は実施例１と同様にして軟性眼内レンズを得た。
【００５６】
得られた軟性眼内レンズにおいて、引張試験による光学部と支持部との接合強度は、約５０ｇであり、光学部と支持部とは強固に接合していた。
【００５７】
（比較例１）
側面部にワイヤ状部材挿入用の穴を有しない通常の成形型の下型内に、実施例１と同一の組成のモノマー混合物を注入して実施例１と同条件で重合を行なって軟性光学部を形成した。重合後、成形型ごとフリーザー中に入れ、冷却しながら軟性光学部に支持部挿入孔を微細ドリルで設けた。しかし、軟性光学部完成後に支持部挿入孔を設けるには、かなりの複雑な手間と時間が必要であった。また、挿入孔には、ドリルの跡が残り孔はきれいに作製できなかった。
【００５８】
次に、実施例１と同様にＰＭＭＡ製フィラメントを熱成形することによって得た支持部を、光学部に設けられた支持部挿入孔に挿入して、適当な一点にステーキングを施した。この操作でロッドが押し当てられた部分の軟性材料は、白化し粉状になってしまった。
【００５９】
得られた眼内レンズの光学部と支持部の接合強度を引張試験により求めたところ約１０ｇであり、接合強度が低かった。
【００６０】
（比較例２）
側面部にワイヤ状部材挿入用の穴を有しない通常の成形型内に、実施例１と同一の組成のモノマー混合物を注入して実施例１と同条件で重合を行なって軟性光学部を形成した。重合後、比較例１と同様な操作で支持部孔を設けた。
【００６１】
支持部孔作製後、支持部孔（０．１７ｍｍ程度）に光学部−支持部接合用モノマーおよびプレポリマーを各々注入しようとしたが、いずれも困難であった。
【００６２】
また、支持部孔作製後、ＰＭＭＡ製フィラメントを熱成形することによって得た支持部を支持部孔挿入前にモノマーおよびプレポリマー各々に浸漬させ、モノマーおよびプレポリマーが各々塗布された状態の支持部を支持部挿入孔に挿入した。しかし、支持部挿入の際、光学部の光学面あるいは支持部挿入孔の周りの部分にモノマー等が付着するなどの問題が生じた。また、支持部に塗布されたモノマーおよびプレポリマーが支持部挿入孔の縁の部分で挿入の際に大部分削り取られてしまった。
【００６３】
得られた眼内レンズの光学部と支持部の接合強度を引張試験により求めたところ約２０ｇであり、接合強度が低かった。
【００６４】
【発明の効果】
以上詳しく述べたように本発明によれは支持部材料が光学部と強固に接合された軟性眼内レンズを容易に製造できる方法が提供された。
【図面の簡単な説明】
【図１】本発明の実施例で用いた成形装置を示す斜視図である。
【図２】本発明の実施例で用いた成形装置を示す平面図である。
【図３】成形型の下型内にワイヤ状部材を配置した状態を示す平面図である。
【図４】重合後に得られた、ワイヤ状部材が埋入している光学部を示す平面図である。
【図５】ワイヤ状部材を抜き取った後の光学部を示す平面図である。
【図６】最終的に得られた軟性眼内レンズを示す平面図である。
【符号の説明】
１ 成形装置
２ 台座
３ 成形型の下型
４ａ，４ｂ，４ｃ，４ｄ ワイヤ状部材挿入穴
５ａ，５ｂ ワイヤ状部材
６ 光学部
７ａ，７ｂ 支持部孔
８ａ，８ｂ 支持部[0001]
BACKGROUND OF THE INVENTION
The present invention relates to a method for manufacturing an intraocular lens, and more particularly, to a method for manufacturing a soft intraocular lens that can be inserted through a small incision by bending an optical part during intraocular insertion.
[0002]
[Prior art]
The intraocular lens is used as an alternative lens for a lens that has been removed or damaged due to a disease or accident such as a cataract, and the intraocular lens includes an optical unit that functions as an alternative lens and an optical unit that is placed in a capsule. In order to fix and hold at the center position, it is comprised from the support part fixedly arranged by the outer periphery of the said optical part.
[0003]
Conventionally, polymethyl methacrylate (PMMA), which is a hard material, has been mainly used as the material of the optical part. The reason why PMMA is used as an optical part of an intraocular lens is that an excellent lens can be obtained because it is excellent in transparency, safety in the body, and machinability. On the other hand, PMMA, polypropylene (PP), etc. are frequently used as the material of the support part. The support part is often formed by preparing a support part member as a material separately from the optical part, and fixing (joining) the support part material at a predetermined position of the optical part, As such a support portion material, an arc-shaped molded product of a filament made of the above-mentioned material is mainly used.
[0004]
In recent years, with the spread of ultrasonic emulsification and the like, intraocular lenses that can be inserted through small incisions have been developed for the purpose of reducing postoperative astigmatism and surgical invasion. This intraocular lens is made of a soft polymer material as an optical part material, so that the optical part can be bent and inserted from a small incision, and is called a soft intraocular lens. .
[0005]
However, it is difficult to subject the soft polymer material to machining, particularly cutting and polishing processes conventionally performed when manufacturing an intraocular lens made of PMMA. Therefore, the optical part is obtained by a cast molding method or the like in which a monomer, a prepolymer, or the like, which is a raw material for forming the optical part, is polymerized in a mold. Also, as a method for attaching the support material, it is difficult to mechanically provide a small hole in the optical part as in the conventional case, and therefore, a method different from the conventional method must be used.
[0006]
As a method for manufacturing such a soft intraocular lens, Japanese Patent Laid-Open Nos. 62-142558 and 62-152450 disclose that a bulb-like mechanical engaging portion is integrally formed at the tip of a filament. The support part material formed in the above, or the support part material formed by joining another member that forms a mechanical engagement part to the tip of the filament, and the tip part of these support part materials are inserted into the mold After that, a method of manufacturing an intraocular lens having a support portion that is difficult to be detached is disclosed by injecting a raw material of a flexible polymer material to be an optical portion and performing heat polymerization.
[0007]
JP-A-4-292609 discloses the following method. That is, after the monomer for the soft optical part is polymerized in the mold to obtain the soft optical part, the mold is cooled in the freezer to increase the hardness of the soft optical part, and the support material is inserted under this condition. A small hole (support part material insertion hole) for insertion and a small hole (anchor filament insertion hole) for inserting the anchor filament are mechanically provided. Next, the support material is inserted into the support material insertion hole provided in the soft optical part, and the filament of the same material as the support material is also inserted into the anchor filament insertion hole, at the intersection of the support material and the anchor filament. A laser beam is irradiated and heat fusion is performed. Further, the intraocular lens is manufactured by irradiating the laser beam along the insertion hole until the anchor filament insertion hole is filled with the filament material.
[0008]
U.S. Pat. No. 5,266,241 also discloses another method for producing a soft intraocular lens, in which a wire having a cross-sectional diameter smaller than the cross-sectional diameter of the support material is disclosed. After placing the shaped member in the mold, the optical part monomer is injected, then the optical part monomer is polymerized to obtain the optical part, and then the wire-like member is removed from the optical part to form the support part hole. Then, the support part material is inserted into the support part hole to expand the support part hole, thereby obtaining a soft intraocular lens in which the support part material is combined with the optical part.
[0009]
[Problems to be solved by the invention]
As described above, there are various methods for producing a soft intraocular lens, all of which involve complicated and complicated operations.
[0010]
That is, in the methods disclosed in Japanese Patent Application Laid-Open Nos. 62-142558 and 62-152450, a filament (support material) serving as a support part is heated so that the tip part has a complicated shape. Must be processed. The filament serving as the support portion has a diameter of about 0.15 mm, and it is necessary to provide a very complicated and fine processing step in order to process all the tip portions into the same shape by heat melting.
[0011]
In the method described in JP-A-4-292609, the soft optical part monomer is polymerized in the mold to obtain the soft optical part, and then the mold is cooled in the freezer to thereby adjust the hardness of the soft optical part. In this state, it is necessary to mechanically provide a support material insertion hole and an anchor filament insertion hole. In addition to melting and fusing the support material inserted into the support material insertion hole and the anchor filament inserted into the anchor filament insertion hole by laser beam irradiation, until the anchor filament insertion hole is filled with the filament material A laser beam must be irradiated.
[0012]
In the method described in US Pat. No. 5,266,241, the support material is inserted into the support hole having a cross-sectional diameter smaller than the cross-sectional diameter of the support material. The operation up to this point is not easy, and the insertion difficulty is particularly remarkable when the support material is polymethyl methacrylate (PMMA).
[0013]
Accordingly, an object of the present invention is to provide a method that can eliminate the drawbacks of the prior art and can easily manufacture a soft intraocular lens in which a support material is firmly joined to an optical part.
[0014]
[Means for Solving the Problems]
The present invention has been made in order to achieve the above object, and an intraocular lens having an optical part and a support part having a tip inserted into a support part hole provided through the optical part. A method,
(I) a step of disposing a wire-like member at a position corresponding to a support hole of the intraocular lens in the lower mold of the optical part forming mold;
(II) After injecting the monomer or prepolymer for the optical part into the lower mold of the mold, the mold is sealed with the upper mold of the mold and the monomer or prepolymer for the optical part is polymerized to embed the wire-like member. Forming an optical part,
(III) A step of extracting the wire-like member from the optical part and forming a support part hole penetrating the optical part, and (IV) an optical part existing in the support part hole after inserting the support part material into the support part hole- the supporting portion bonding monomer or prepolymer is polymerized saw including a step of bonding a support material in the optical portion,
In step ( IV ), after inserting the support part material, the tip of the support part material protruding from the exit side of the support part hole is brought into contact with the optical part-support part joining monomer or prepolymer, and the optical part-support is obtained by capillary action. A soft intraocular lens characterized in that an optical part-support part joining monomer or prepolymer is present in the support part hole by allowing the part joining monomer or prepolymer to enter the support part hole. The manufacturing method is as a gist.
[0015]
DETAILED DESCRIPTION OF THE INVENTION
The present invention relates to a method for manufacturing an intraocular lens having an optical part and a support part having a distal end inserted into a support part hole provided through the optical part, and includes steps (I) to ( IV) is included as an essential process.
[0016]
Hereinafter, steps (I) to (IV) will be sequentially described.
[0017]
Step (I) is a step of arranging a wire-like member at a position corresponding to the support hole of the intraocular lens in the lower mold of the optical part forming mold.
[0018]
As the mold for forming an optical part, a mold having any shape capable of forming an optical part by polymerizing a monomer or a prepolymer for an optical part can be used. The mold usually consists of an upper mold and a lower mold, and the lower mold has a cavity for containing the monomer or prepolymer for the optical part, and the cavity has an inner bottom surface of the lower mold and an inner bottom surface of the lower mold. It is formed by a circular side surface portion formed in a plan view.
[0019]
In this step (I), a wire-like member is arranged at a position corresponding to the support hole of the intraocular lens in the lower mold of the optical part forming mold described above.
[0020]
Any wire-like member may be used as long as it does not affect the optical part during the formation of the optical part. For example, polyolefin such as polypropylene (PP); polyvinylidene fluoride (PVDF), ethylene / tetrafluoride Fluoropolymers such as ethylene copolymer (ETFE), tetrafluoroethylene / hexafluoropropylene copolymer (FEP), perfluoroalkoxy fluororesin (PFA), polytetrafluoroethylene (PTFE); iron, aluminum, Examples include those made of metal such as brass. As will be described later, since the support portion hole is formed by this wire-like member, and the support portion is finally inserted and fixed in this support portion hole, the cross-sectional diameter of the wire-like member is equal to the cross-sectional diameter of the support portion or It is preferably slightly larger.
[0021]
In this step (I), the wire-shaped member is disposed in the lower mold of the mold at a position corresponding to the support hole of the intraocular lens. In particular, the wire-shaped member is disposed on the inner periphery of the lower mold of the mold. It is preferable to arrange in a curved shape so as to form an elliptical shape with the surface. The reason for this is that by arranging the wire-like member in this way, a support portion hole having the same curved shape is obtained. According to the support portion hole having such a curved shape, the support portion material in the post-process (IV) will be described later. This is because the insertion is performed very smoothly.
[0022]
When it is desired to obtain an intraocular lens in which two support portions are fixed to the optical portion, the arrangement of the two wire-like members in this step (I) is set to 1 at a position where the side surface portion of the lower mold faces substantially. It is preferable to use a mold having a pair of wire-like member insertion holes, insert a wire member from one hole of each pair of wire-like member insertion holes, and protrude the wire member from the other hole.
[0023]
In the step (II) performed after the step (I), the monomer or prepolymer for the optical part is injected into the lower mold of the mold, and then the mold is sealed with the upper mold of the mold. This is a step of polymerizing the prepolymer to form an optical part in which the wire-like member is embedded.
[0024]
As the monomer or prepolymer for the optical part used in this step (II), any monomer or prepolymer capable of forming a soft optical part by polymerization can be used, and in particular, a (meth) acrylate monomer or prepolymer, Examples include silicone monomers or prepolymers, hydrogel monomers or prepolymers, and the like. In the present specification, the “prepolymer” means a liquid polymer obtained by prepolymerizing a monomer, and is a concept including an oligomer and the like.
[0025]
Since this step (II) is the same as the optical part forming operation by polymerization of a normal optical part monomer or prepolymer, except that an optical part in which a wire-like member is embedded is obtained, detailed steps are not required. Description is omitted.
[0026]
The step (III) performed after the step (II) is a step of extracting the wire-like member from the optical part and forming a support part hole penetrating the optical part.
[0027]
As described above, the wire-shaped member is made of, for example, polyolefin, fluororesin, metal, etc., and has no affinity with the optical part monomer or prepolymer and the optical part obtained by polymerization of these monomers or prepolymers. In step (III), the wire-like member is extracted from the optical part very smoothly. As a result, the inner surface of the formed support part hole is also very smooth.
[0028]
Note that the wire-like member can be easily extracted from the optical portion using tweezers or the like.
[0029]
In the step (IV) performed after the step (III), the support part material is inserted into the support part hole, and then the optical part-support part joining monomer or prepolymer existing in the support part hole is polymerized to polymerize the optical part. It is the process of joining support part material to.
[0030]
In this step (IV), the support portion material is smoothly inserted into the support portion hole since the support portion hole has a smooth inner surface as described above. If the cross-sectional diameter of the support hole is slightly larger than the cross-sectional diameter of the support material, the insertion of the support material into the support hole is further facilitated.
[0031]
In this step (IV), the optical part-support part joining monomer or prepolymer present in the support part hole is then polymerized to join the support part material to the optical part.
[0032]
The optical part-support part bonding monomer or prepolymer is not particularly limited as long as it can bond the optical part and the support part, but a (meth) acrylate monomer or prepolymer, a silicone monomer or A prepolymer, an epoxy resin, a photocurable resin, or the like is used.
[0033]
There are various methods for allowing the monomer or prepolymer for joining the optical part to the support part to exist in the support part hole. For example, the tip of the support part material protruding from the exit side of the support part hole after the support part material is inserted is used as the optical part. -A method of bringing the optical part-support part joining monomer or prepolymer into the support part hole by capillarity by contacting with the support part joining monomer or prepolymer is preferable.
[0034]
In this step (IV), polymerization of the optical part-support part joining monomer or prepolymer present in the support part hole is performed under normal conditions, and the support part material is firmly joined to the optical part by polymerization. An intraocular lens is obtained.
[0035]
According to the intraocular lens manufacturing method of the present invention, the following technical advantages are obtained.
[0036]
(A) It is not necessary to form a bulb-like mechanical engagement portion at the tip of the support portion material, and the support portion material can be used as it is.
[0037]
(B) Unlike conventional methods in which laser beam irradiation is performed after cooling in a freezer as a pretreatment for joining the flexible optical portion and the support portion, such treatment is unnecessary. The manufacturing operation is simple.
[0038]
(C) The support part material is smoothly and quickly inserted into the support part hole, and the optical part and the support part material are joined using a bonding agent, so that the optical part and the support part material are firmly joined.
[0039]
【Example】
EXAMPLES The present invention will be further described below with reference to examples, but these examples are illustrative and do not limit the present invention.
[0040]
In addition, a tensile test was performed in order to evaluate the bondability between the support part and the optical part of the intraocular lens obtained in the following examples. In this test, the tensile strength was determined by fixing the optical part of the intraocular lens. It was obtained by pulling the support part in the vertical direction and measuring the force (g) required for the support part to be detached from the optical part. Detailed measurement conditions are as follows.
[0041]
Measuring machine: Instron universal tensile testing machine Measuring temperature: 25 ° C
Measurement humidity: 65%
Sample support method: Chuck load cell: 1kg
Tensile speed: 5.0 mm / min [0042]
Example 1
1 is a perspective view, and FIG. 2 is a plan view. In this molding apparatus 1, a lower mold 3 of a molding die for accommodating an optical part forming monomer is provided at the center of a pedestal 2. A pair of holes 4a and 4b are provided in the side surface portion of the lower mold 3 of the molding die, and another pair of holes 4c and 4d are provided in the side surface portion substantially facing the holes 4a and 4b.
[0043]
A wire-like member 5a made of fluororesin (polyvinylidene fluoride) is inserted from one of the pair of holes 4a, 4b of the lower die 3 of the molding die, and the wire-like member 5a in the lower die 3 of the molding die is shown in FIG. Then, the tip of the wire-like member 5a was taken out from the other hole. Similarly, a wire member 5b made of fluororesin is inserted from one of the other pair of holes 4c and 4d of the lower mold 3 of the mold, and the wire member 5b in the lower mold 3 of the mold is shown in FIG. Then, the tip of the wire-like member 5b was taken out from the other hole. In this manner, the wire-like members 5a and 5b are arranged in the mold 3 at positions corresponding to the support hole of the intraocular lens.
[0044]
Next, a monomer mixture for forming a flexible optical part having the following composition was injected into the lower mold 3 of the mold.
[0045]

[0046]
After injecting the monomer mixture, the lower mold 3 of the mold is sealed with an upper mold (not shown), and heat polymerization is performed at a nitrogen pressure of 2.0 kg / cm ² and a temperature of 110 ° C. for 2 hours, and the resulting polymer is molded. After releasing from the mold, as shown in FIG. 4, the flexible optical part 6 in which the wire-like members 5a and 5b were embedded was obtained.
[0047]
Next, the wire-like members 5a and 5b were extracted from the flexible optical part 6 to obtain a flexible optical part 6 having support part holes 7a and 7b penetrating the optical part 6 as shown in FIG.
[0048]
Next, the support portions 8a and 8b obtained by thermoforming the PMMA filament are inserted from the entrance side of the support portion holes 7a and 7b, and the tips of the support portions 8a and 8b are inserted from the exit side of the support portion holes 7a and 7b. I let it stick out.
[0049]
Next, the tips of the support parts 8a and 8b protruding from the outlets of the support part holes 7a and 7b are added to the optical part-support part bonding prepolymer (a polymerization initiator is added to the methyl methacrylate monomer, And the prepolymer was allowed to enter the support holes 7a and 7b by capillary action.
[0050]
After the prepolymer entered the support portion holes 7a and 7b, the prepolymer was allowed to stand at a temperature of about 80 ° C. for 24 hours to polymerize the prepolymer, and the optical portion and the support portion were joined.
[0051]
Thus, as shown in FIG. 6, the support portions 8 a and 8 b are inserted into the support portion holes 7 a and 7 b in the optical portion 6, and a soft intraocular lens that is firmly bonded to the optical portion 6 is obtained. . This soft intraocular lens was placed in a bottle containing glass beads, abrasive and water and barrel polished for 5 days.
[0052]
In this way, the optical unit is an intraocular lens having a support part hole provided through the optical part, and the tip of the support part is inserted and fixed in the support part hole. An intraocular lens was obtained in which the tip of the part was arranged in a curved shape so as to form an elliptical shape together with the outer peripheral surface of the optical part.
[0053]
In the soft intraocular lens obtained in this example, the tip of the support portion material was firmly bonded to the optical portion, and the bonding strength between the optical portion and the support portion was determined by the tensile test to be about 50 g. It was.
[0054]
In this embodiment, the elliptical shape formed by the outer peripheral surface of the optical part and the tip part of the support part is a flat shape with a relatively thin middle part as shown in FIG. It may be a thick oval shape. The elliptical shape is appropriately determined in consideration of the insertion property of the support portion material at the time of manufacturing the intraocular lens, the bonding property between the support portion and the optical portion in the intraocular lens, and the like.
[0055]
(Example 2)
As a monomer mixture for flexible optics,

A soft intraocular lens was obtained in the same manner as in Example 1 except that the polymerization was carried out in a thermostatic bath at 80 ° C. for 48 hours.
[0056]
In the obtained soft intraocular lens, the bonding strength between the optical part and the support part by a tensile test was about 50 g, and the optical part and the support part were firmly bonded.
[0057]
(Comparative Example 1)
A monomer mixture having the same composition as in Example 1 is injected into a lower mold of a normal mold that does not have a hole for inserting a wire-like member on the side surface, and polymerization is performed under the same conditions as in Example 1 for soft optics. Part was formed. After the polymerization, the mold was placed in a freezer and a support insertion hole was provided in the soft optical part with a fine drill while cooling. However, in order to provide the support portion insertion hole after the completion of the soft optical portion, a considerably complicated work and time are required. Moreover, the trace of the drill remained in the insertion hole, and the hole could not be made cleanly.
[0058]
Next, the support part obtained by thermoforming the PMMA filament as in Example 1 was inserted into the support part insertion hole provided in the optical part, and staking was performed at an appropriate point. The soft material of the portion where the rod was pressed by this operation was whitened and powdered.
[0059]
When the joint strength between the optical part and the support part of the obtained intraocular lens was determined by a tensile test, it was about 10 g, and the joint strength was low.
[0060]
(Comparative Example 2)
A monomer mixture having the same composition as in Example 1 is injected into a normal mold having no hole for inserting a wire-like member on the side surface, and polymerization is performed under the same conditions as in Example 1 to form a flexible optical part. did. After the polymerization, a support hole was provided by the same operation as in Comparative Example 1.
[0061]
After the support hole was made, an attempt was made to inject the optical part-support part bonding monomer and prepolymer into the support hole (about 0.17 mm), but both were difficult.
[0062]
In addition, after the support part hole is prepared, the support part obtained by thermoforming the PMMA filament is immersed in each of the monomer and the prepolymer before the support part hole is inserted, and the support part in a state where the monomer and the prepolymer are respectively applied. Was inserted into the support portion insertion hole. However, when the support portion is inserted, there arises a problem that a monomer or the like adheres to the optical surface of the optical portion or a portion around the support portion insertion hole. In addition, most of the monomer and prepolymer applied to the support part were scraped off at the edge of the support part insertion hole during insertion.
[0063]
When the joint strength between the optical part and the support part of the obtained intraocular lens was determined by a tensile test, it was about 20 g, and the joint strength was low.
[0064]
【The invention's effect】
As described above in detail, according to the present invention, a method for easily producing a soft intraocular lens in which the support material is firmly bonded to the optical part is provided.
[Brief description of the drawings]
FIG. 1 is a perspective view showing a molding apparatus used in an embodiment of the present invention.
FIG. 2 is a plan view showing a molding apparatus used in an example of the present invention.
FIG. 3 is a plan view showing a state in which a wire-like member is disposed in a lower mold of a mold.
FIG. 4 is a plan view showing an optical part in which a wire-like member is embedded, obtained after polymerization.
FIG. 5 is a plan view showing an optical unit after a wire-like member is extracted.
FIG. 6 is a plan view showing the finally obtained soft intraocular lens.
[Explanation of symbols]
DESCRIPTION OF SYMBOLS 1 Molding apparatus 2 Base 3 Lower molds 4a, 4b, 4c, 4d of molding die Wire-like member insertion holes 5a, 5b Wire-like member 6 Optical part 7a, 7b Support part hole 8a, 8b Support part

Claims (9)

A method for producing an intraocular lens having an optical part and a support part having a tip inserted into a support part hole provided through the optical part,
(I) a step of disposing a wire-like member at a position corresponding to a support hole of the intraocular lens in the lower mold of the optical part forming mold;
(II) After injecting the monomer or prepolymer for the optical part into the lower mold of the mold, the mold is sealed with the upper mold of the mold and the monomer or prepolymer for the optical part is polymerized to embed the wire-like member. Forming an optical part,
(III) A step of extracting the wire-like member from the optical part and forming a support part hole penetrating the optical part, and (IV) an optical part existing in the support part hole after inserting the support part material into the support part hole- the supporting portion bonding monomer or prepolymer is polymerized saw including a step of bonding a support material in the optical portion,
In step ( IV ), after inserting the support part material, the tip of the support part material protruding from the exit side of the support part hole is brought into contact with the optical part-support part joining monomer or prepolymer, and the optical part-support is obtained by capillary action. A soft intraocular lens characterized in that an optical part-support part joining monomer or prepolymer is present in the support part hole by allowing the part joining monomer or prepolymer to enter the support part hole. Manufacturing method.   In step (I), the wire-shaped member is arranged in a curved shape so as to form an elliptical shape with the inner peripheral surface of the lower mold of the molding die, and as a result, a curved support hole is formed in step (III). The method of claim 1.   In step (I), in order to arrange two wire-like members in the lower die of the optical part forming die, a pair of wire-like member insertion holes are provided at positions substantially facing the side surface portion of the lower die. The method according to claim 1, wherein a mold is used.   The method according to claim 1, wherein the wire-like member is made of polyolefin, fluororesin, or metal.   The method according to claim 1, wherein the optical part monomer or prepolymer is selected from a (meth) acrylate monomer or prepolymer, a silicone monomer or prepolymer, a hydrogel monomer or prepolymer.   The method according to claim 1, wherein the support material is constituted by polypropylene, polymethyl methacrylate, a copolymer of methyl methacrylate and other monomers, polyamide, polyvinylidene fluoride, polyimide, or polycarbonate.   The method according to claim 1, wherein the monomer or prepolymer for joining the optical part and the support part is selected from a (meth) acrylate monomer or prepolymer, a silicone monomer or prepolymer, an epoxy resin, and a photocurable resin. An optical unit is an intraocular lens having a support hole provided through the optical unit, and the tip of the support is inserted and fixed in the support hole. An intraocular lens obtained by the method according to claim 2, which is arranged in a curved shape so as to form an elliptical shape together with the outer peripheral surface of the optical part. The intraocular lens according to claim 8 , wherein the optical portion and the distal end portion of the support portion material are bonded together by a bonding agent.

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