JP3799151B2 - Topical skin preparation - Google Patents

Description

【００２８】
実験例２ 美肌作用
実施例１の化粧水、実施例３の乳液、比較例１の従来の化粧水および比較例２の従来の乳液を用いて、肌荒れに悩む女性１５人（２１〜４６才）を対象に１ヶ月間の使用試験を行った。使用後、肌荒れの改善効果をアンケートにより判定した。その結果を表２に示した。その結果、磯松の抽出物を含有することを特徴とする皮膚外用剤は優れた美肌作用を示した。
【００２９】
【表２】

【００３０】
実施例２のクリーム、実施例４のゲル剤、実施例５の軟膏、実施例６のパック、実施例７のファンデーション、実施例８のヘアークリームおよび実施例９の浴用剤についても同様に使用試験を行ったところ、優れた美肌作用を示した。
以上示したように、本発明の磯松の抽出物は優れたヒスタミンの遊離を抑制する作用を有し、さらに、その抽出物を含有することを特徴とする皮膚外用剤は優れた美肌作用を示した。[0001]
[Industrial application fields]
The present invention relates to a skin external preparation characterized by containing an extract of pine cones.
[0002]
[Prior art]
In the Nansei Islands, pine pine is used for the treatment of arthritis by drinking stems and leaves, but it has been cultivated for viewing purposes.
On the other hand, there is skin inflammation caused by ultraviolet rays or the like as a cause of rough skin, and an external preparation for skin that subsides the inflammation and improves rough skin is desired. As one of the treatment methods, there is a method for suppressing the release of histamine, which is a inflammatory substance that occurs during inflammation. However, most conventional skin external preparations having an inhibitory action on histamine release contain substances obtained by chemical synthesis such as steroids, and there is a risk of side effects. An excellent natural product-derived skin external preparation is desired.
[0003]
[Problems to be solved by the invention]
Therefore, as a natural product, we examined the application of pine pine extract to the topical skin preparation. As a result, it is highly safe, exhibits excellent anti-inflammatory action (histamine release inhibitory action) and skin beautification, and can also be formulated. Thus, the present invention has been completed.
[0004]
[Means for Solving the Problems]
The present invention is a skin external preparation characterized by containing an extract of pine cones.
Limonium wrightii O. Kuntze in the present invention is a dicotyledonous small shrub perennial plant belonging to the genus Isomatsuaceae, and is distributed from Izu-Nanashima, south of Yakushima to Taiwan and Ogasawara. In addition, this pine is also called Haidian in Taiwan.
[0005]
The extract of juniper pine used in the present invention is obtained by extracting from a part of a plant of pine pine leaves, stems, flowers, berries, roots or whole plants. Preferably, it is obtained by extraction from one or both of leaves and stems. The preparation method is not particularly limited, and for example, it may be extracted by heating or may be extracted at room temperature. Examples of the solvent to be extracted include water, lower monohydric alcohols (methanol, ethanol, 1-propanol, 2-propanol, 1-butanol, 2-butanol, etc.), liquid polyhydric alcohols. (1,3-butylene glycol, propylene glycol, etc.), esters (ethyl acetate, isopropyl myristate, etc.), hydrocarbons (benzene, hexane, pentane, liquid paraffin, etc.), ketones (acetone, methyl ethyl ketone, etc.), ether (Ethyl ether, tetrahydrofuran, propyl ether, etc.), acetonitrile and the like. These solvents may be used alone or in combination of two or more. Preferably, one or two or more of water or a water-soluble solvent (a solvent that can be mixed with water in an arbitrary ratio, such as ethanol, 1,3-butylene glycol, propylene glycol, etc.) may be used. .
[0006]
Moreover, the extract of Juniper may be used as it is, or may be used after being subjected to treatments such as concentration, dilution, and filtration as necessary.
[0007]
Oils and waxes, waxes, hydrocarbons, fatty acids, alcohols, esters, which are components used in normal skin external preparations, as long as they do not impair the effect of the extract of pine cones , Surfactants, metal soaps, pH adjusters, preservatives, fragrances, moisturizers, powders, UV absorbers, thickeners, dyes, antioxidants, cosmetic ingredients, chelating agents, etc. it can.
[0008]
The skin external preparation of the present invention can be used for any of pharmaceuticals, quasi drugs, and cosmetics. Examples of the dosage form include skin lotions, creams, emulsions, gels, aerosols, ointments, and patches. Agents, paste agents, plaster agents, essences, packs, cleaning agents, bath preparations, foundations, powders, lipsticks and the like.
[0009]
The compounding amount of the extract of pine cone used in the present invention is 0.0001% by weight or more, preferably 0.001 to 10% by weight in terms of the dry solid in the total amount of the external preparation for skin of the present invention. If it is less than 0.001% by weight, a sufficient effect cannot be expected. When it exceeds 10% by weight, the effect is not enhanced and it is uneconomical. In addition, the addition method may be added in advance or during the production, and may be appropriately selected in consideration of workability.
[0010]
【Example】
EXAMPLES Next, although an Example is given and this invention is demonstrated in detail, this invention is not limited to this. In addition, the part of the compounding amount shown in the Examples means part by weight, and% means% by weight.
[0011]
Manufacture example 1 Juniper hot water extract 1000 ml of water is added to 50 g of a mixture of Juniper stalk and leaves, extracted at 95-100 ° C. for 2 hours, filtered, and the filtrate is concentrated to dryness. 10.5 g of extract was obtained.
[0012]
Production Example 2 Juniper ethanol extract 1000 ml of ethanol was added to 50 g of mushroom leaves, extracted at room temperature for 7 days, filtered, and the filtrate was concentrated and dried to obtain 4.0 g of Juniper ethanol extract.
[0013]
Production Example 3 Juniper 1,3-Butylene Glycol Extract To 1000 g of 1,3-butylene glycol was added to 50 g of dried pine pine herb, extracted for 10 days at room temperature, filtered, and Jematsu 1,3-butylene glycol 800 g of extract was obtained.
[0014]
Example 1 lotion formula
1. Kashimatsu hot water extract (Production Example 1) 0.1 part
2. 1,3-Butylene glycol 8.0
3. Glycerin 2.0
4. Xanthan gum 0.02
5. Citric acid 0.01
6. Sodium citrate 0.1
7. Ethanol 5.0
8. Methyl paraoxybenzoate 0.1
9. Polyoxyethylene hydrogenated castor oil (40E.O.) 0.1
10. Perfume appropriate amount
11. Make the total amount to 100 with purified water [Production method] Components 1 to 6, 11 and 7 to 10 are uniformly dissolved, mixed and filtered to obtain a product.
[0015]
Comparative Example 1 Conventional lotion In Example 1 of the conventional lotion, the hot spring water extract was replaced with purified water.
[0016]
Example 2 Cream formulation
1. Junimatsu ethanol extract (Production Example 2) 0.05 part
2. Squalane 5.5
3. Olive oil 3.0
4. Stearic acid 2.0
5. Beeswax 2.0
6. Octyldodecyl myristate 3.5
7. Polyoxyethylene cetyl ether (20E.O.) 3.0
8. Behenyl alcohol 1.5
9. Glycerol monostearate 2.5
10. 1,3-Butylene glycol 8.5
11. Methyl paraoxybenzoate 0.2
12. Ethyl paraoxybenzoate 0.05
13. Fragrance 0.1
14. Make the total amount to 100 with purified water [Production method] Components 2 to 9 are dissolved by heating and mixed, and kept at 70 ° C to obtain an oil phase. Ingredients 1, 10-12, and 14 are heated and dissolved and mixed, and kept at 75 ° C. to form an aqueous phase. Add the aqueous phase to the oil phase, emulsify, cool with stirring, add component 13 at 45 ° C, and cool to 30 ° C to make the product.
[0017]
Example 3 Emulsion formulation
1. Kashimatsu 1,3-butylene glycol extract (Production Example 3) 1.0 part
2. Squalane 5.0
3. Olive oil 5.0
4. Jojoba oil 5.0
5. Cetanol 1.5
6. Glycerol monostearate 2.0
7. Polyoxyethylene cetyl ether (20E.O.) 3.0
8. Polyoxyethylene sorbitan monooleate (20E.O.) 2.0
9. Propylene glycol 1.0
10. Glycerin 2.0
11. Methyl paraoxybenzoate 0.2
12. Fragrance 0.1
13. Make the total amount to 100 with purified water [Production Method] Components 2 to 8 are dissolved by heating and mixed, and kept at 70 ° C to obtain an oil phase. Ingredients 1, 9-11, and 13 are heated and dissolved and mixed, and kept at 75 ° C. to form an aqueous phase. Add the aqueous phase to the oil phase, emulsify, cool with stirring, add component 12 at 45 ° C, and cool to 30 ° C to make the product.
[0018]
Comparative Example 2 Conventional Emulsion In Example 3, the conventional emulsion was prepared by replacing the Kamamatsu 1,3-butylene glycol extract with 1,3-butylene glycol.
[0019]
Example 4 Gel formulation formulation
1. Kashimatsu 1,3-butylene glycol extract (Production Example 3) 5.0 parts
2. Ethanol 5.0
3. Methyl paraoxybenzoate 0.1
4. Polyoxyethylene hydrogenated castor oil (60E.O.) 0.1
5. Perfume appropriate amount
6. 1,3-Butylene glycol 5.0
7. Glycerin 5.0
8. Xanthan gum 0.1
9. Carboxyvinyl polymer 0.2
10. Potassium hydroxide 0.2
11. Make the total amount 100 with purified water [Manufacturing method] Components 2 to 5 and components 1 and 6 to 11 are uniformly dissolved, mixed and filtered to obtain a product.
[0020]
Example 5 Ointment Formulation Amount
1. Kashimatsu hot water extract (Production Example 1) 1.0 part
2. Polyoxyethylene cetyl ether (30E.O.) 2.0
3. Glycerol monostearate 10.0
4. Liquid paraffin 5.0
5. Cetanol 6.0
6. Methyl paraoxybenzoate 0.1
7. Propylene glycol 10.0
8. Make the total amount to 100 with purified water [Production Method] Components 2 to 5 are heated and dissolved and mixed, and kept at 70 ° C to obtain an oil phase. Ingredients 1 and 6 to 8 are dissolved by heating and mixed, and kept at 75 ° C to form an aqueous phase. Add the water phase to the oil phase, emulsify, and cool to 30 ° C with stirring to make the product.
[0021]
Example 6 Pack formulation
1. Hamamatsu Hot Water Extract (Production Example 1) 0.5 part
2. Polyvinyl alcohol 12.0
3. Ethanol 5.0
4. 1,3-Butylene glycol 8.0
5. Methyl paraoxybenzoate 0.2
6. Polyoxyethylene hydrogenated castor oil (20E.O.) 0.5
7. Citric acid 0.1
8. Sodium citrate 0.3
9. Perfume appropriate amount
10. Make the total amount to 100 with purified water. [Production method] Dissolve components 1 to 10 uniformly to make a product.
[0022]
Example 7 Foundation formulation
1. Kashimatsu 1,3-butylene glycol extract (Production Example 3) 1.0 part
2. Stearic acid 2.4
3. Polyoxyethylene sorbitan monostearate (20E.O.) 1.0
4. Polyoxyethylene cetyl ether (20E.O.) 2.0
5. Cetanol 1.0
6. Liquid lanolin 2.0
7. Liquid paraffin 3.0
8. Isopropyl myristate 6.5
9. Butyl paraoxybenzoate 0.1
10. Carboxymethylcellulose sodium 0.1
11. Bentonite 0.5
12. Propylene glycol 4.0
13. Triethanolamine 1.1
14. Methyl paraoxybenzoate 0.2
15. Titanium dioxide 8.0
16. Talc 4.0
17. Bengala 5.0
18. Perfume appropriate amount
19. Make the total amount 100 with purified water [Manufacturing method] Add component 10 well swelled with component 10 and dissolve component 13 in the remaining component 19, then components 1, 11 Add ~ 14 and mix uniformly to make the aqueous phase. Ingredients 2-9 are dissolved by heating and kept at 80 ° C. to form an oil phase. Ingredients 15 to 17 are pulverized with a pulverizer, added to the aqueous phase, stirred with a homomixer and kept at 75 ° C. Add oil phase to this water phase with stirring, cool, add component 18 at 45 ° C, cool to 30 ° C with stirring to make the product.
[0023]
Example 8 Hair cream formulation
1. Stearic acid 2.0 parts
2. Stearyl alcohol 2.0
3. Liquid paraffin 8.0
4. Glycerol monostearate 2.3
5. Sorbitan monooleate 2.5
6. Polyoxyethylene sorbitan monooleate (10E.O.) 0.8
7. Juniper 1,3-butylene glycol extract (Production Example 3) 0.2
8. Glycerin 6.0
9. Methyl paraoxybenzoate 0.1
10. Perfume appropriate amount
11. Make the total amount to 100 with purified water [Production method] Components 1 to 6 are dissolved by heating and mixed, and kept at 70 ° C to form an oil phase. Ingredients 7 to 10 are heated and dissolved and mixed, and kept at 75 ° C. to form an aqueous phase. Add the water phase to the oil phase, emulsify, cool with stirring, add component 10 at 45 ° C, and cool to 30 ° C to make the product.
[0024]
Example 9 Formulation for bath preparation
1. Sodium bicarbonate 50.0 parts
2. Kashimatsu hot water extract (Production Example 1) 0.5
3. Yellow 202 No.
4. Perfume appropriate amount
5. Make the total amount 100 with sodium sulfate. [Production method] Ingredients 1 to 5 are uniformly mixed to make a product.
[0025]
【The invention's effect】
The pine extract of the present invention has an excellent histamine release inhibitory action (anti-inflammatory action), and the skin external preparation characterized by containing the pine extract has an excellent skin beautifying action.
Next, experimental examples will be given to explain the effects of the present invention in detail.
[0026]
Experimental Example 1 Action to suppress histamine release (anti-inflammatory action)
Histamine release inhibitory action was measured using mast cells collected from the abdominal cavity of male Spraque-Dawley rats. That is, the effect of inhibiting histamine release from mast cells by 1 μg / ml compound 48/80 was determined as the release inhibition rate. Mast cells were collected by the method of Sullivan et al. (J. Immunology, 114 (5), 1473, 1975), and histamine was quantified by the method of May et al. (J. Allergy, 46, 12-20, 1970). The results of the experiment are shown in Table 1. As a result, the pine extract showed an excellent inhibitory effect on histamine release. The sample used was a freeze-dried product of the extracts of Production Examples 1 and 2, and an evaporation residue of the extract of Production Example 3.
[0027]
[Table 1]

[0028]
Experimental Example 2 Skin beautification 15 women (21 to 46 years old) who suffer from rough skin using the lotion of Example 1, the emulsion of Example 3, the conventional lotion of Comparative Example 1 and the conventional emulsion of Comparative Example 2. A one-month use test was conducted on the subjects. After use, the improvement effect of rough skin was judged by a questionnaire. The results are shown in Table 2. As a result, the external preparation for skin characterized by containing an extract of pine cones showed an excellent skin beautifying action.
[0029]
[Table 2]

[0030]
The use test was similarly applied to the cream of Example 2, the gel of Example 4, the ointment of Example 5, the pack of Example 6, the foundation of Example 7, the hair cream of Example 8, and the bath preparation of Example 9. As a result, it showed an excellent skin effect.
As described above, the pine extract of the present invention has an excellent inhibitory effect on the release of histamine, and the external preparation for skin characterized by containing the extract exhibits an excellent skin beautifying effect. It was.

Claims (1)

A skin external preparation characterized by containing an extract of pine cones.