JP3973420B2 - Method for producing wound dressing - Google Patents

Description

[0001]
BACKGROUND OF THE INVENTION
The present invention relates to a method for manufacturing a wound dressing material that covers and protects a wound surface of a body, such as a bandage and a dressing agent.
[0002]
[Prior art]
Conventionally, as disclosed in, for example, Japanese Patent Application Laid-Open No. 59-139267, a jelly-like disinfectant for the purpose of sterilization and cleaning of the skin surface has been proposed by mixing gelatin or agar with a disinfectant to jelly. Yes. In addition, a wound adhesive plaster or the like in which a sterilizing / disinfecting solution is blister packed, and the pack is destroyed during use and a chemical solution is soaked into a pad portion.
[0003]
[Problems to be solved by the invention]
The above prior art has drawbacks such as high manufacturing costs, long-term stability of the product, and difficult operations such as breaking the pack during use.
[0004]
The present invention has been made in view of the above-described conventional problems, and provides a method for manufacturing a wound dressing that is easy to manufacture, inexpensive, easy to use, and capable of maintaining a bactericidal effect for a long time. For the purpose.
[0005]
[Means for Solving the Problems]
The present invention is a wound dressing material having a hydrogel layer in which a disinfectant is dissolved in a pad portion. The hydrated gel layer is held on a gel support, the gel support is held on an adhesive support, and the hydrated gel layer, gel support, and adhesive support are all made of a transparent material. May be.
[0006]
The hydrated gel layer is a hydrated gel layer containing a drug such as ethyl alcohol or a water-soluble disinfectant. The hydrated gel layer is made of a water-soluble polymer material such as a polymer polysaccharide that dissolves by heating and solidifies by cooling. The water-soluble polymer material of the above-mentioned polymer polysaccharide is mannan, agar, gelatin, gellan gum, gum arabic, or tragacanth rubber, and may be polyvinyl pyrrolidone, or a polymer composed of one or more materials selected from these. Material.
[0007]
The hydrogel layer is made of a water-soluble polymer material that is solidified by a chemical reaction. The water-soluble polymer material is a synthetic polymer containing sodium alginate or polyvinyl alcohol.
[0008]
The gel support is a non-woven fabric, a woven fabric, or a nylon net that is a nylon net. The hydrated gel layer is provided in a shallow container formed of a resin film.
[0009]
Moreover, the adhesive support material is a nonwoven fabric, a woven fabric, a resin film, or the like, as long as it can apply the adhesive. In particular, when composed of a woven fabric or a non-woven fabric, moisture evaporation from the hydrated gel layer is promoted, and the cooling effect on the wound surface is enhanced.
[0010]
Further, the present invention also includes an aqueous solution of a water-soluble polymer, which is a polymeric polysaccharide constituting a hydrous gel, partially adsorbed on one side of a gel support and gelled, and then the gel support is used as an adhesive support. It is a manufacturing method of the wound dressing material affixed on this adhesive layer. The hydrated gel layer is formed integrally on the sheet-like gel support, formed into a predetermined size by punching, and the gel support is affixed to the pressure-sensitive adhesive layer of the pressure-sensitive adhesive support.
[0011]
DETAILED DESCRIPTION OF THE INVENTION
Hereinafter, embodiments of the present invention will be described with reference to the drawings. 1 and 2 show a first embodiment of the present invention. A wound dressing 10 according to this embodiment is a pressure-sensitive adhesive support made of a thin film such as a thin polyester film or tape, or other thin woven or non-woven fabric. A material 12, a pressure-sensitive adhesive layer 14 provided on one surface of the pressure-sensitive adhesive support material 12, and a water-containing gel layer 16 provided at the center of the surface on which the pressure-sensitive adhesive layer 14 is formed are provided. The hydrogel layer 16 is held by a gel support 18 to form a pad portion 15 and is attached to the pressure-sensitive adhesive layer 14.
[0012]
The pressure-sensitive adhesive layer 14 may be formed on one side, but has air permeability by being partially formed on the surface of the pressure-sensitive adhesive support material 12 by wave coating or the like, and the moisture content of the hydrogel layer 16 Does not interfere with evaporation.
[0013]
Further, by forming the pressure sensitive adhesive support material 12, the pressure sensitive adhesive layer 14, the hydrated gel layer 16 and the gel support body 18 from a transparent material, the affected area is externally attached with the wound dressing material 10 of the present invention applied thereto. Can be observed from.
[0014]
The water-containing gel layer 16 is a gel layer made of a water-soluble polymer material of polymer polysaccharide that is mixed with water, heated and dissolved, and solidified by cooling. The water-soluble polymer material is composed of one or more materials selected from mannan, agar, gelatin, gellan gum, polyvinyl pyrrolidone, gum arabic, or tragacanth gum. The compounding quantity of a gel formation material is about 0.1 to 5% of the whole.
[0015]
The material of the hydrogel layer 16 may be a water-soluble polymer material that gels by a chemical reaction. This water-soluble polymer material is a synthetic polymer containing sodium alginate or polyvinyl alcohol.
[0016]
The gel support 18 is a non-woven fabric or a thin woven fabric, and has a basis weight of 30 to 100 g / m ² , preferably 50 to 70 g / m ² , and is most preferably a stretchable non-woven fabric. As the fibers forming the gel support 18, fibers such as rayon, pulp and cotton can be used in addition to synthetic fibers such as polyester, polypropylene and acrylic. Alternatively, a nylon net that is a nylon net may be used.
[0017]
The hydrogel layer 16 and the pressure-sensitive adhesive layer 14 are covered with a release film 20 of a polyester film embossed or coated with silicon so that it can be easily peeled off.
[0018]
The water-containing gel layer 16 contains, as a disinfectant, acrinol, chlorhexidine gluconate, cetylpyridium, ethyl alcohol, isopropanol, benzalkonium chloride, chlorpheniramine maleate, and the like. Furthermore, you may mix | blend chemical | medical agents, such as lidocaine as a local anesthetic, and allantoin as a skin repair agent.
[0019]
Further, glycerin, isopropyl alcohol, ethylene glycol, polypropylene glycol, polyethylene glycol, 1,3-butylene glycol, other polyglycerin, and the like can be used for the hydrogel layer 16 as a moisturizing agent. The blending amount of the humectant is about 0.1 to 10%, preferably 0.5 to 5% with respect to the weight of the hydrated gel layer 16.
[0020]
In the water-containing gel layer 16 of this embodiment, organic salts, oils, surfactants, inorganic powders, inorganic salts, preservatives, pH adjusters, pigments, fragrances, and other medicinal ingredients are used according to the purpose of use. be able to.
[0021]
Next, the manufacturing method of the wound dressing 10 of this embodiment is demonstrated. First, the water-containing gel layer 16 is formed by heating and pouring an aqueous solution of a water-soluble polymer into a predetermined thin mold, and before the aqueous solution gels, the gel support 18 such as a nonwoven fabric is placed on the water-soluble polymer layer 16. The solution is placed on the surface of the aqueous solution, soaked into the gel support 18 and gelled. Alternatively, a water-soluble polymer aqueous solution may be flowed on the surface of a support-type material such as a large nonwoven fabric to cause gelation, and then the hydrogel layer 16 and the gel support 18 may be cut into a predetermined shape. In this case, the water-containing gel layer 16 having an arbitrary size can be obtained.
[0022]
After the hydrogel layer 16 is gelled, a gel support 18 having a predetermined shape is attached to the central portion of the pressure-sensitive adhesive layer 14. And the peeling film 20 is affixed on the adhesive layer 14 and the water-containing gel layer 18 surface, and seals and packages.
[0023]
According to the wound dressing of this embodiment and the manufacturing method thereof, the hydrogel layer 16 is in contact with the wound surface of the skin, so that natural healing can be accelerated without interfering with cell proliferation. In addition, since the surface of the hydrogel layer 16 is smooth and flexible, it can be in close contact with the uneven wound surface, and the drug in the gel acts uniformly on the wound site and reliably prevents bacteria from entering. To do. The hydrogel layer 16 does not adhere to the wound site, cures quickly, and has no pain when the wound dressing 10 is replaced. Further, since the gel support 18 has air permeability, the affected part can be cooled by heat of vaporization due to evaporation of moisture from the hydrogel layer 16. Furthermore, when the adhesive support material 12 is comprised with a woven fabric or a nonwoven fabric, the moisture evaporation from a water-containing gel layer is accelerated | stimulated and the cooling effect of a wound surface is high. Moreover, since the gel of the water-containing gel layer 16 is easily broken by pressing the pad portion 15 including the water-containing gel layer 16 by hand to separate the gel solution, the drug in the gel permeates the wound surface. It's easy to do.
[0024]
Next, a second embodiment of the present invention will be described. In the wound dressing 24 of this embodiment, the hydrogel layer 16 is accommodated in a thin CPP film container 26, and the adhesive layer 14 is also covered by the film extension 28 of the film container 26.
[0025]
In the method of manufacturing the wound dressing 24 of this embodiment, first, a water-soluble polymer aqueous solution similar to the above is poured into the film container 26, and the gel support 18 such as a nonwoven fabric is opened in the film container 24 before gelation. The gel support 18 is soaked with the water-soluble polymer solution. Thereafter, the water-containing gel layer 16 is formed by cooling, and the pressure-sensitive adhesive layer 14 of the pressure-sensitive adhesive support material 12 is attached to the gel support 18 and the extension 28 of the film container 26. Then, seal and package.
[0026]
According to this embodiment, the same effect as described above can be obtained, and further, the hydrogel layer 16 is protected from being deformed after packaging.
[0027]
In addition, the wound dressing material of this invention and its manufacturing method are not limited to said each embodiment, A perforated resin film, a thin cloth, a nonwoven fabric, etc. may be sufficient as an adhesive support material. Moreover, the shape of the hydrogel layer can be set as appropriate. The disinfectant and other chemicals may be mixed in the water-containing gel layer in addition to being dissolved or emulsified or dispersed.
[0028]
【Example】
Hereinafter, the wound dressing of the first embodiment of the present invention will be described. In this example, 1.5 parts of agar is mixed with 97.3 purified water and dissolved by heating, and 1 part of glycenline and 0.2 part of acrinol are sequentially mixed and dissolved while keeping at 90 ° C. 2.225 g of this solution is dropped into a resin container having a size of 50 mm × 45 mm and a depth of 1 mm, and the container is filled with the liquid. Then, before the solution gels, a polypropylene nonwoven fabric having a basis weight of 100 g / m ² cut to 53 mm × 48 mm is placed on the opening of the container, the solution is soaked into the nonwoven fabric, the solution is cooled and solidified, and the nonwoven fabric and the hydrous gel Integrate the layers. After gelling, the nonwoven fabric integrated with the hydrogel layer is separated from the resin container, the non-woven fabric surface is attached to the adhesive tape, and a silicone-coated polyester film is applied to the adhesive surface and the hydrogel layer, Seal and package.
[0029]
Next, a wound dressing according to a second embodiment of the present invention will be described. In this example, 1.5 parts of agar was mixed with 82.1 parts of purified water and dissolved by heating. While keeping at 90 ° C., 15 parts of ethyl alcohol was mixed with 0.1 part of benzalkonium chloride, 1 part of lidocaine hydrochloride, A solution in which 0.1 part of naphazoline hydrochloride and 0.2 part of chlorpheniramine maleate are dissolved is dispersed and mixed. 0.3 g of this solution is dropped into a container made of a CPP resin film having a recess of 20 mm × 14 mm and a depth of 1 mm and silicon-coated on the surface of the recess, and the container is filled with the solution. Then, before the solution is gelled, a polypropylene nonwoven fabric having a basis weight of 100 g / m ² cut to 22 mm × 16 mm on the solution surface is placed on the container opening so that the solution soaks into the nonwoven fabric, and the solution is cooled and solidified. The nonwoven fabric and the hydrogel layer are integrated. After the gelation, an adhesive tape is attached to the film container with the nonwoven fabric exposed on the surface and its extended portion, and hermetically packaged.
[0030]
【The invention's effect】
According to the method for manufacturing a wound dressing of the present invention, a wound dressing can be manufactured at low cost with a simple apparatus. And since a hydrous gel layer contacts the wound surface of skin, natural healing can be accelerated | stimulated without interfering with the proliferation of a cell compared with the adhesive bandage which gauze etc. contact | wins a wound surface. In addition, since the surface of the hydrogel layer is smooth and flexible, it can adhere to an uneven wound surface without damaging the wound surface. Certainly prevent intrusion. Furthermore, the hydrogel layer does not adhere to the wound site, cures quickly, and does not cause pain when the wound dressing is replaced. Further, the affected part can be cooled by heat of vaporization caused by evaporation of water from the hydrous gel layer.
[Brief description of the drawings]
FIG. 1 is a plan view of a wound dressing according to a first embodiment of the present invention.
FIG. 2 is a cross-sectional view of the wound dressing of this embodiment.
FIG. 3 is a cross-sectional view of a wound dressing according to a second embodiment of the present invention.
[Explanation of symbols]
DESCRIPTION OF SYMBOLS 10 Wound dressing material 12 Adhesive support material 14 Adhesive layer 15 Pad part 16 Hydrous gel layer 18 Gel support 20 Release film

Claims (1)

A sheet-like nonwoven gel support made of rayon, pulp or cotton fibers before the aqueous solution of the water-soluble polymer material of the polymer polysaccharide constituting the hydrogel is thinly spread and cooled, and the aqueous solution gels. Is applied to the surface of the aqueous solution to allow the aqueous solution to permeate the gel support, integrally form a layer of the hydrogel on the sheet-like gel support, and the aqueous solution gels. A gel support formed by punching a support in a predetermined shape at the center of the pressure-sensitive adhesive layer of a cloth pressure-sensitive adhesive support formed by punching the support into a predetermined size and having a pressure-sensitive adhesive layer on one side Is attached to the central portion of the pressure-sensitive adhesive layer of the pressure-sensitive adhesive support material .

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