JP4035009B2 - A simple method for producing an iodine-containing article, an iodine gas sustained-release device having water resistance, and a disinfection system using them. - Google Patents

Description

[0001]
BACKGROUND OF THE INVENTION
The present invention relates to a simple method for producing an iodine-containing article using an iodine sustained-release polymer compound adsorbed with iodine as an iodine gas generation source.
[0002]
[Prior art]
Attempts have been made to adsorb iodine to a fiber sheet to develop a bactericidal effect. For example, JP-A-1-124688 discloses a bactericidal fabric containing an iodo complex adduct and describes fibers such as nylon and acrylic as the fabric. JP-A-11-50376 discloses a vinylon nonwoven fabric carrying an iodine compound. In any of these, a fiber sheet is immersed or applied in an iodine compound solution to adsorb iodine to the fiber. However, the treatment of the fiber sheet using the iodine solution has a problem that the operation is complicated and the treatment of the waste liquid containing iodine is necessary.
[0003]
On the other hand, disinfection of hands and instruments is extremely important in hospitals to prevent infection by microorganisms, but commonly used biguanide fungicides, quaternary ammonium salt fungicides, polyvinylpyrrolidone and iodine complexes, Alcohol has problems such as rough hand, antibacterial spectrum and usability, and is not satisfactory in all aspects. Therefore, development of a more excellent disinfectant or disinfection system is desired.
[0004]
In addition, in order to protect the sterile water faucet for hand washing used in hospital operating rooms from microbial back-contamination, plastic beads that have adsorbed iodine are inserted into the faucet, and iodine eluted from the beads is used. . The purpose of this method is to prevent contamination from the faucet by disinfecting the water remaining in the faucet. Need not be released. Therefore, limiting the release of iodine during use increases the period of use of the beads. However, in the conventional method, since the beads are in direct contact with water, there is a disadvantage that iodine is wasted due to the heated water when the apparatus is used.
[0005]
Conventionally, in hospitals and the like, ultraviolet rays, formaldehyde gas, and the like are often used to disinfect instruments, but there are problems in that expensive equipment is required and there is danger to the human body.
[0006]
Furthermore, it cannot be said that there is a sufficiently simple and reliable method for disinfection of hospital rooms and floors. In addition, disinfection performed by general users like contact lenses is safe and reliable for disinfection in which equipment is immersed in a liquid. However, the ideal situation has not yet emerged.
[0007]
[Problems to be solved by the invention]
The present invention has been made in the background as described above, and the object of the present invention is to manufacture iodine-containing articles that can be easily and safely manufactured at hospitals and homes for disinfection, particularly the production of fiber sheets containing iodine. It is to provide a method.
[0008]
[Means for Solving the Problems]
As a result of various studies to achieve the above object, the present inventors have succeeded in achieving the object by using a polymer compound adsorbed with iodine as an iodine gas generation source, and reached the present invention.
[0009]
That is, the gist of the present invention is a method for producing an iodine-containing article characterized in that iodine is adsorbed on the article using a polymer compound adsorbing iodine as an iodine gas generation source. As a polymer compound adsorbing iodine, beads, powders, fibers, films, fabrics, selected from the group consisting of ABS resin, AS resin, ethylene / vinyl alcohol copolymer, polyamide, polyvinyl alcohol, formalized polyvinyl alcohol, etc. Nonwoven fabric or gel is used.
[0010]
A fiber sheet containing a polyamide epichlorohydrin resin or a polyamine / polyamide epichlorohydrin resin is preferably used as an article for adsorbing iodine gas from the polymer compound adsorbing iodine, and the iodine-containing fiber sheet is wetted with water. Can be used to provide a powerful disinfection method.
[0015]
Note that. In JP-A-9-67217, JP-A-9-122655, and JP-A-10-165960, an antibacterial composition that gradually releases iodine in water by adsorbing iodine to plastic and bringing it into contact with water. However, the present invention has developed a novel method in which iodine is adsorbed on a plastic and used as an iodine gas sustained-release agent without contacting it with water.
[0016]
DETAILED DESCRIPTION OF THE INVENTION
In the present invention , as the polymer compound adsorbed with iodine used as an iodine gas generation source, a compound obtained by adsorbing iodine to a polymer compound having iodine adsorptivity is used. Plastics having iodine adsorptivity include ABS resin, AS resin, ethylene / vinyl alcohol copolymer (EVOH), ethylene / vinyl acetate copolymer, polyamide, polyacrylonitrile, acrylonitrile / vinyl chloride copolymer resin, polyurethane resin, Cellulose acetate resin, polyvinyl alcohol, formalized polyvinyl alcohol, polyester, polyethylene oxide resin, starch, polyvinylpyrrolidone copolymer (for example, vinylpyrrolidone / methyl methacrylate copolymer) and the like are used. Moreover, even if it is resin with poor iodine adsorptivity, it becomes useable by mixing and shape | molding said iodine adsorptive resin.
[0017]
Among these plastics, ABS resin, AS resin, and ethylene / vinyl alcohol copolymer (EVOH) are particularly desirable because they are excellent in iodine adsorption. In general, those commercially available as ABS resins are 20 to 30% by weight of the acrylonitrile component, 40 to 70% by weight of the styrene component, and 10 to 30% by weight of the butadiene component, but any of them can be used in the present invention. It is. As the EVOH-based resin, one having an ethylene content of 20 to 50 mol% in the copolymer is preferably used. As commercial products, any of the various types of Soarnol manufactured by Nippon Synthetic Chemical Industry Co., Ltd. and various types of Eval manufactured by Kuraray Co., Ltd. can be used.
[0018]
The polymer compound adsorbed with iodine can be used in various forms such as beads, powder, fiber, woven fabric or nonwoven fabric, film or gel. Also, a molded product by thermoforming such as injection molding, extrusion molding, compression molding or the like can be used. The preferred form varies depending on the method of use, application, etc., but from the viewpoint of the ease of the iodine adsorption process, a bead or powder is preferred. As a bead-like form, plastic material injection molding pellets are advantageous because commercially available products can be used as they are. It is also possible to use a finely pulverized injection molding pellet.
[0019]
In order to obtain a polymer compound in which iodine is adsorbed from an iodine adsorbing polymer compound material (hereinafter abbreviated as a polymer material), it is necessary to adsorb iodine in the polymer material. The liquid phase method in which a polymer material is immersed in an iodine solution may be used for adsorption of iodine. However, it is easier to operate by the gas phase method, the adsorption amount can be easily increased, and waste liquid can be produced. It is advantageous because it is not. The method for adsorbing iodine to a polymer material is described in detail in JP-A-10-165960. That is, the vapor phase adsorption of iodine is performed by putting the polymer material and solid iodine in a sealed container and heating to 50 ° C to 110 ° C. The heating is performed until all the solid iodine is adsorbed on the polymer material, but the time varies depending on the kind and form of the polymer material and the amount of iodine to be adsorbed.
[0020]
The amount of iodine adsorbed on the polymer material is preferably 5 to 200% by weight. A material having a large surface area such as a powder may have a relatively small amount of iodine adsorption, and a material having a small surface area requires a relatively large amount. A desirable adsorption amount is 10 to 200% by weight, particularly preferably 30 to 150% by weight (with respect to plastic weight) in the form of beads. In the case of powder, the iodine adsorption amount is suitably about 10 to 100% by weight (vs. plastic weight).
[0021]
For example, when adsorbing 100% by weight of iodine to an ABS resin molding pellet, the iodine is mixed by mixing with solid iodine equivalent to the resin pellet in an airtight container and heating at 50 to 100 ° C. for 1 to 10 hours. Can be completely adsorbed.
[0022]
When iodine is adsorbed on the polymer material and then heat treatment is performed at a temperature higher than the temperature at the time of adsorption, iodine penetrates further into the polymer material. In this case, the iodine sustained release rate from the polymer compound adsorbed with iodine decreases, but iodine can be released gradually for a longer time. The sustained release rate of iodine can be adjusted by the amount of iodine adsorbed and the heat treatment conditions. When the polymer material is a fine powder, iodine penetrates into the inside without performing heat treatment, but since the release of iodine is fast, the time for sustained release becomes shorter.
[0023]
As the polymer compound to which iodine is adsorbed, a gel of a hydrophilic polymer compound impregnated with an iodine solution can be used in addition to the polymer compound in which iodine is adsorbed as described above.
[0024]
In the present invention, an iodine-containing article can be easily produced by adsorbing iodine to an iodine-adsorbing article using the above-described polymer compound adsorbing iodine as an iodine gas generation source. Here, the iodine adsorbing article means an article having an ability to adsorb iodine.
[0025]
As iodine-adsorbing articles, polymer compounds such as cellulose, polyacrylonitrile-based polymer, polyamide, polyester, ethylene / vinyl alcohol copolymer, polyvinyl alcohol, and partially formalized polyvinyl alcohol are used. Resins are poor in iodine adsorption. Glass, earthenware, etc. have no adsorptivity.
[0026]
A specific example of a method for producing an iodine-containing article by adsorbing iodine to an iodine-adsorbing article using a polymer compound that has adsorbed iodine as an iodine gas generation source is a removable lid provided with a packing. The iodine-adsorbing article adsorbs iodine gas that is slowly released from the iodine-adsorbing polymer compound simply by placing the iodine-adsorbing polymer compound and iodine-adsorbing article in a closed container having Thus, iodine-containing articles are automatically manufactured.
[0027]
The iodine-containing article may be produced at room temperature or warmed. When heated, the amount of iodine gas generated increases, and iodine can be adsorbed to the iodine-adsorbing article in a short time. The temperature for heating is preferably about 30 to 60 ° C. The time for adsorbing iodine from the iodine gas sustained-release agent to the iodine-adsorbing article varies depending on the form of the iodine-adsorbing article, the iodine sustained-release amount of the iodine-releasing agent, etc., but is usually 1 hour to 1 month at room temperature. When heated to 40-50 ° C., the time can be shortened to a fraction.
[0028]
When the polymer compound adsorbing iodine is in the form of beads or powder, it can be used by being coated with a material having iodine resistance, such as using a nonwoven fabric such as polyolefin-based fibers and putting it in a bag such as a tee bag.
[0029]
According to the method for producing an iodine-containing article of the present invention, an iodine-containing article can be obtained in the gas phase by using a polymer compound that adsorbs iodine as an iodine generation source and coexisting with the iodine-adsorbing article. Compared with conventional methods, iodine-containing articles can be manufactured much more easily. That is, the polymer compound adsorbed with iodine used in the present invention does not generate intense iodine gas unlike solid iodine, and gently releases iodine, so it is easy to handle and is handled in an open ordinary room. I can do it. Further, as described above, it is easy to adjust the sustained release amount of iodine depending on the production conditions. Moreover, since it is not necessary to use water, there is no waste liquid and there is no concern about exhaust. Therefore, according to the method of the present invention, an iodine-adsorbing article for disinfection can be prepared easily and safely even in a hospital room or at home.
[0030]
The iodine-containing article produced by the method for producing an iodine-containing article of the present invention can be used as an antibacterial article or material. It is also useful for disinfecting applications.
[0031]
Among the iodine-containing articles produced by the method of the present invention, a particularly useful form is a fiber sheet. The fiber sheet may be paper, non-woven fabric, woven fabric, or knitted fabric. In order to produce an iodine-containing fiber sheet material, it is sufficient that the fibers constituting the sheet material have an ability to adsorb iodine. Cellulosic fibers (cotton, regenerated cellulose fibers, acetate fibers), polyamides, polyesters, and acrylic fibers all have iodine adsorption ability. For production of the iodine-containing fiber sheet material, for example, the polymer compound adsorbing iodine is stored in a closed container having a detachable lid, and the iodine-adsorbing fiber sheet material is placed in the container. When the fiber sheet is adsorbed with sufficient iodine under the conditions described below, it can be removed from the container and used as an iodine-containing fiber sheet. In this case, it is necessary to adjust the necessary adsorption time depending on the amount of the polymer compound that has adsorbed iodine and the rate of sustained release of iodine gas.
[0032]
It is preferable to use hydrophilic cellulosic fibers as the fiber sheet for disinfection. For this reason, cotton gauze, regenerated cellulose nonwoven fabric and the like can be used, but these require a long time for adsorption because of their relatively low iodine adsorption capacity. On the other hand, when the cellulose fiber sheet is treated with a polyamine / polyamide-based or polyamide epichlorohydrin-based resin, the iodine adsorbing ability is increased and a large amount of iodine can be adsorbed in a short time. The fiber sheet is immersed in an aqueous solution of the resin and squeezed, and then dried at 100 to 110 ° C. to crosslink with the hydroxyl group of cellulose, thereby increasing the water resistance of the sheet and at the same time a fiber sheet having a high iodine adsorption capacity. Things are obtained. These epichlorohydrin-based resins are generally used as wet paper strength enhancers for paper, and are commercially available, for example, as “Harmide PY-410” and “Harmide PY-430” from Harima Kasei Co., Ltd.
[0033]
The above-mentioned wet paper strength enhancer is usually used for tissue papers and paper wipers currently on the market. For this reason, commercially available tissue papers and wipers can be advantageously used as materials for iodine-containing fiber sheets. In particular, JK wipers, Keidry, and Kimwipes commercially available from Crecia Co., Ltd. are preferred because of their excellent iodine adsorption. Commercially available tissue paper can also be used, but the iodine adsorptivity is somewhat low. Among them, for example, Lmore from Kami Shoji Co., Ltd. can be used because it is relatively excellent in iodine adsorption.
[0034]
When a fiber sheet-like material having high iodine adsorptivity is used, the time required for iodine adsorption is usually 2, 3 to 30 hours at room temperature. In the case of cellulose fibers alone such as cotton gauze and pure regenerated cellulose nonwoven fabric, it takes 30 hours or more. When the temperature is increased, the time required for adsorption is greatly reduced. The amount of iodine adsorbed on the fiber sheet is usually about 0.01% to 2.5% by weight. As a disinfectant fiber sheet, a sufficient effect can be exhibited even at 0.5% by weight or less.
[0035]
The iodine-containing fiber sheet can be used for various purposes, but is particularly useful for disinfecting fingers and instruments. In order to use the iodine-containing fiber sheet for the purpose of disinfection, the objective can be achieved by wiping the fingers, instruments and the like by wetting the iodine-containing fiber sheet with water such as tap water. Moreover, since iodine elutes in water when an iodine-containing fiber sheet is immersed in water, iodine water for disinfection can be easily produced. Such a disinfection method can be used in a wide range of fields such as hospitals, clinics, food industries, food cooking places, nursing homes, home care.
[0061]
【Example】
In order to clarify the present invention more specifically, some examples will be shown below.
[0062]
Experimental example 1
200 g of Diapet ABS (variety PS-505) molding pellets (Mitsubishi Rayon Co., Ltd.) and 260 g of iodine flakes (Nippon Natural Gas Co., Ltd.) were placed in a polypropylene bottle, sealed, and sealed at 65 ° C. The iodine was completely adsorbed by heating with occasional shaking in the oven. Subsequently, after heating at 80 degreeC for 12 hours, it heat-processed at 105 degreeC for 24 hours. From the increase in the weight of the pellet, it was found that 130% by weight of iodine was adsorbed on the pellet with respect to the ABS weight. 12 g of this pellet was packed into a bag for a tee bag and heat sealed.
[0063]
Example 1
Six pieces of ABS resin pellets adsorbed with iodine obtained in Experimental Example 1 are placed in a 18 × 12 × 6 cm plastic square container, and 20 pieces of JK Wiper (Crea Co., Ltd.) are put into a lid with packing. And sealed with a clip. After leaving for 24 hours at room temperature, the JP wiper was taken out and one of them was immersed in 200 ml of water to obtain iodine water with a concentration of 18 ppm. It was found that sufficient iodine was adsorbed for disinfection. Moreover, even after repeating this operation 30 times, the amount of iodine adsorbed on the JP wiper hardly changed, and it was confirmed that it could be used many times.
[0064]
Example 2 and Comparative Example 1
The hand disinfection effect of the iodine-containing article produced by the method of the present invention was examined. First, in order to examine the germs of the palm before disinfection, tryptosoy agar medium (Pearl Core “Eiken” lot 13102) was placed in a disposable petri dish with a diameter of 35 mm and a depth of 10 mm and pressed against the palms of four subjects. Next, as Comparative Example 1, one JP wiper was wetted with sterilized ion-exchanged water, and after squeezing, the palm of four subjects was wiped for 10 seconds, and then the medium was pressed against the palm in the same manner as above. Next, as Example 2, one JP wiper on which iodine was adsorbed in Example 1 was wetted with sterilized ion-exchanged water, and after squeezing, the palms of four subjects were wiped for 10 seconds. Pressed. Each medium was cultured at 33 ° C. for 48 hours, and then the growth state of the bacteria was observed. Regarding the palm before wiping with a wiper and the palm wiped with an iodine non-adsorbed wiper, a large number of bacterial colonies were observed for any subject, but for any subject with a palm wiped with an iodine-adsorbed wiper The fungus was almost gone. Thereby, the outstanding disinfection effect of the iodine containing article of the present invention was confirmed.
[0065]
Example 3 and Comparative Example 2
The disinfection effect of the container using the iodine-containing article produced by the method of the present invention was examined. As a model of a table having a rough surface, the inner surface of a plastic petri dish was scratched with a cutter in the shape of a grid at intervals of 0.5 cm. A bacterial solution of S. aureus ATCC 6538 (5.0 × 10 ⁶ cfu / ml) was prepared, and 100 μl thereof was added to the petri dish and spread over the whole. As Comparative Example 2, one JP wiper was wetted with sterilized ion-exchanged water, and after squeezing, the inner surface of the petri dish was wiped for 10 seconds, then 2 ml of an inactivating agent-containing diluent (DPPBST solution) was added and vortexed with the petri dish. Was collected, diluted appropriately, and cultured at 33 ° C. for 48 hours using a soy bean casein medium (SCDLP medium) containing an inactivating agent. The number of viable bacteria was determined, and the viable cell count was 1.1 × 10 ^5. It was. In addition, as Example 3, one JP wiper on which iodine was adsorbed in Example 1 was wetted with sterilized ion-exchanged water, and after squeezing, the inner surface of the petri dish was wiped for 10 seconds in the same manner as in Comparative Example 2, and the same as in Comparative Example 2 When the viable cell count was measured after treatment, the viable cell count was 0. Next, a bacterial solution of E. coli ATCC 8739 (5.2 × 10 ⁶ cfu / ml) was prepared and tested in the same manner as above. As for the wiper not adsorbing iodine, 6.0 × 10 6 was obtained. ⁴ cfu / ml viable bacteria were detected. On the other hand, for the wiper on which iodine was adsorbed in Example 2, the viable cell count was zero. Thereby, it was confirmed that the iodine-containing article of the present invention is effective for disinfection of the container.
[0077]
【The invention's effect】
According to the present invention, an iodine-containing article such as an iodine-containing fiber sheet can be safely prepared as shown in Example 1 by using an iodine gas sustained-release agent as an iodine gas generation source. Its preparation is very simple and inexpensive. Moreover, the iodine gas sustained release agent of an iodine gas generation source can be used repeatedly many times.
[0078]
The obtained fiber sheet-like material becomes a powerful disinfecting sheet simply by immersing in tap water or the like, and can be used for disinfection of fingers, disinfection of equipment, etc. as shown in Examples 2 and 3. This is simple and effective compared to the conventional method. The disinfecting system of the present invention can also be used for disinfecting around the iodine gas sustained-release agent and disinfecting gauze and cloths.

Claims (6)

Iodine that is sustainedly released from an iodine sustained-release polymer compound that adsorbs 10 to 200% by weight of iodine ,
A method for producing an iodine-adsorbing fiber sheet , wherein iodine is adsorbed by contacting with one or more fiber sheet-like materials selected from the group consisting of cellulosic fibers, polyamide fibers, polyester fibers, and acrylic fibers . The iodine sustained-release polymer compound is composed of ABS resin, AS resin, ethylene / vinyl alcohol copolymer, polyamide, polyacrylonitrile, polyacrylonitrile / vinyl chloride copolymer, polyvinyl alcohol, and formalized polyvinyl alcohol adsorbed with iodine. The method for producing an iodine-adsorbing fiber sheet according to claim 1, which is a polymer compound selected from the group consisting of: The method for producing an iodine-adsorbing fiber sheet according to claim 1 or 2 , wherein the iodine sustained-release polymer compound is in the form of beads, powders, fibers, films, woven fabrics, nonwoven fabrics or gels. The iodine sustained-release polymer compound is disposed in a closed container having a lid that can be opened and closed, and the closed container is selected from the group consisting of cellulose fibers, polyamide fibers, polyester fibers, and acrylic fibers. The method for producing an iodine-adsorbing fiber sheet according to any one of claims 1 to 3, wherein at least one fiber sheet is allowed to coexist . The method for producing an iodine-adsorbing fiber sheet according to any one of claims 1 to 4, wherein the fiber sheet-like product is treated with a polyamide epichlorohydrin resin or a polyamine / polyamide epichlorohydrin resin.   6. The method for producing an iodine-adsorbing fiber sheet according to claim 5, wherein the fiber sheet-like material is paper or non-woven fabric using a polyamide epichlorohydrin resin or a polyamine / polyamide epichlorohydrin resin as a paper strength enhancer.