JP4152103B2 - Prefilled syringe - Google Patents

Description

[0001]
BACKGROUND OF THE INVENTION
The present invention relates to a syringe, and more particularly to a prefilled syringe in which a medicine is stored in advance.
[0002]
[Prior art]
A prefilled syringe in which a medicine is stored in advance is known. The prefilled syringe includes an outer cylinder having a mouth portion reduced in diameter on the distal end side, a gasket inserted into the outer cylinder from a proximal end opening of the outer cylinder, and a pusher (plunger rod) connected to the gasket. The powdered medicine is stored in a sealed state in a space surrounded by the outer cylinder and the front end surface of the gasket.
[0003]
In such a prefilled syringe, an operation of pulling the pusher in the proximal direction is performed, the gasket is slid in the proximal direction in the outer cylinder, and a liquid such as an infusion is sucked and introduced from the mouth of the distal end of the outer cylinder. And after melt | dissolving a chemical | medical agent in this liquid and obtaining a chemical | medical solution, operation which pushes a pushing element is performed, a gasket is slid in a front-end | tip direction within an outer cylinder, and a chemical | medical solution is discharged | emitted from an opening | mouth part.
[0004]
However, in such a prefilled syringe, it is necessary to perform both the operation of pulling the pusher and the operation of pushing, and there is a problem that the operation is complicated. In particular, in the operation of pulling the pusher, since the pusher is pulled with the other hand while holding the outer cylinder with one hand, it is necessary to use both hands, and the operation cannot be completed with only one hand.
[0005]
[Problems to be solved by the invention]
An object of the present invention is to provide a prefilled syringe that does not require an operation of pulling a pusher when introducing a liquid and is excellent in operability.
[0006]
[Means for Solving the Problems]
Such an object is achieved by the present inventions (1) to (5) below. Moreover, it is preferable that it is following (6)-(13).
[0007]
(1) a bottomed cylindrical outer cylinder having a mouth portion through which liquid can enter and exit on the tip side;
A gasket that is arranged in the outer cylinder and slides with its entire circumference in close contact with the inner peripheral surface of the outer cylinder;
A pusher connected to the gasket and moving the gasket in the longitudinal direction of the outer cylinder;
A sealing member that seals the proximal end opening of the outer cylinder and has an insertion hole for inserting the pusher;
Fixing means for fixing the sealing member to the base end portion of the outer cylinder and immobilizing the sealing member;
A prefilled syringe comprising a medicine housed in a first space surrounded by the outer cylinder and the gasket located on the distal end side of the gasket,
The pusher has a close sliding portion that slides while its outer peripheral surface is in close contact with at least a part of the insertion hole,
The second space surrounded by the outer cylinder, the gasket and the sealing member located on the base end side of the gasket, and the first space are respectively in a reduced pressure state,
A portion of the pusher is inserted through the second space in a reduced pressure state ;
When the liquid flows into the first space from the mouth and the pressure in the first space increases and the differential pressure with the second space increases, the differential pressure causes the gasket to move to the base end. The prefilled syringe is configured such that the gasket and the pusher connected to the gasket are automatically moved in the proximal direction in response to a force in the direction .
[0008]
(2) It has a ventilation part on the base end side from the contact sliding part of the pusher, and air flows into the second space through the ventilation part, thereby reducing the decompressed state of the second space. The prefilled syringe according to (1), which is configured to be released.
[0009]
(3) The pre-filled syringe according to (2), wherein the ventilation portion is configured by a groove formed on an outer peripheral surface of the pusher.
[0010]
(4) When the volume of the first space is V ₁ and the volume of the second space is V ₂ , V ₂ / V ₁ is 0.3 to 50 above (1) to (3) The prefilled syringe in any one.
[0011]
(5) When the pressure of the first space is P ₁ [atmospheric pressure] and the pressure of the second space is P ₂ [atmospheric pressure], P ₂ / P ₁ is 0.2 to 5 above (1 The prefilled syringe according to any of (4) to (4).
[0012]
(6) The prefilled syringe according to any one of (1) to (5), wherein the gasket and the pusher are connected by screwing.
[0013]
(7) The prefilled syringe according to any one of (1) to (6), wherein at least a portion of the sealing member that comes into contact with the contact sliding portion is made of an elastic material.
[0014]
(8) The part of the sealing member that contacts the close sliding portion is configured by at least one ring-shaped protrusion that protrudes from the inner surface of the insertion hole toward the center. The prefilled syringe according to any one of (7).
[0015]
(9) The prefilled syringe according to any one of (1) to (8), further including a fixing unit that fixes the sealing member to a proximal end portion of the outer cylinder.
[0016]
(10) The prefilled syringe according to any one of (1) to (9), wherein the sealing member is made of a gas-impermeable material.
[0017]
(11) The prefilled syringe according to any one of (1) to (10), wherein the mouth is sealed with an openable film.
[0018]
(12) The prefilled syringe according to (11), wherein the membrane is opened by being pierced with a needle body.
[0019]
(13) The prefilled syringe according to any one of (1) to (12), wherein the medicine is in a powder form.
[0020]
DETAILED DESCRIPTION OF THE INVENTION
Hereinafter, the prefilled syringe of the present invention will be described in detail based on preferred embodiments shown in the accompanying drawings.
[0021]
FIGS. 1 and 2 are longitudinal sectional views showing an exploded state and an assembled state in the embodiment of the prefilled syringe of the present invention, respectively, and FIGS. 3 to 7 are respectively when the prefilled syringe shown in FIGS. 1 and 2 is used. FIG. For convenience of explanation, the upper side in FIGS. 1 to 7 is referred to as a “base end”, and the lower side is referred to as a “tip”.
[0022]
A prefilled syringe (hereinafter simply referred to as “syringe”) 1 of the present embodiment is a syringe in which a medicine is stored in advance in the syringe, and slides within an outer cylinder (syringe outer cylinder) 2 and the outer cylinder 2. A gasket 3 to be obtained, a pusher (plunger rod) 4 for moving and operating the gasket 3, and a sealing member 5 for sealing the proximal end opening of the outer cylinder 2 are provided. The gasket 3 is connected to the tip of the pusher 4.
[0023]
The outer cylinder 2 is formed of a bottomed cylindrical member, and a reduced diameter part 22 that is reduced in diameter relative to the body part of the outer cylinder 2 is integrally formed at the center of the bottom part 21. The reduced diameter portion 22 forms a mouth portion through which liquid can enter and exit.
[0024]
A film 24 made of an elastic material is attached to the tip of the reduced diameter portion 22 as a sealing member, and the lumen 23 of the reduced diameter portion 22 is hermetically sealed.
[0025]
A cap 25 is fitted and fixed to the outside of the reduced diameter portion 22. An opening 26 is formed at the tip of the cap 25, and the membrane 24 is hermetically sealed by sandwiching the outer periphery of the membrane 24 between the edge of the opening 26 and the tip surface of the reduced diameter portion 22. Liquid-tight).
[0026]
The reduced diameter portion 22, the film 24, and the cap 25 are preferably bonded or fused together with an adhesive.
[0027]
The membrane 24 can be pierced by a needle body such as a double-ended needle described later. In this case, as long as the membrane 24 can be pierced by the needle body, the form is not limited to the membrane shape, and may be a block shape (plug body), for example.
[0028]
As the constituent material of the film 24, for example, those listed as constituent materials of the gasket 3 described later can be used. In particular, it is preferably made of a material having gas impermeability (gas barrier properties).
[0029]
The cap 25 is used by being connected to a holder 7 described later, and also functions as a connection part with the holder 7.
[0030]
A plate-like flange 27 is integrally formed on the outer periphery of the base end of the outer cylinder 2. When the pusher 4 is moved relative to the outer cylinder 2, the operation can be performed by placing a finger on the flange 27.
[0031]
Further, a locking portion (fixing means) 28 for locking to the outer edge portion of the fixing portion 54 of the sealing member 5 to be described later and fixing the sealing member 5 is formed on the outer peripheral portion proximal end side of the flange 27. Has been. In the present embodiment, the locking portion 28 is formed in a ring shape over the entire circumference of the flange 27, but is not limited thereto, and may be formed partially such as a claw member, for example.
[0032]
As a constituent material of the outer cylinder 2, for example, polyvinyl chloride, polyethylene, polypropylene, cyclic polyolefin, polystyrene, poly- (4-methylpentene-1), polycarbonate, acrylic resin, acrylonitrile-butadiene-styrene copolymer, Various resins such as polyesters such as polyethylene terephthalate and polyethylene naphthalate, butadiene-styrene copolymers, and polyamides (for example, nylon 6, nylon 6,6, nylon 6,10, nylon 12) can be mentioned. Resins such as acrylic resins and polyesters are preferred because they are easy to mold and have gas impermeability (gas barrier properties).
[0033]
In addition, it is preferable that the constituent material of the outer cylinder 2 is substantially transparent in order to ensure internal visibility.
[0034]
Moreover, the scale 29 is formed in the outer peripheral surface of the outer cylinder 2 (refer FIG. 1). Thereby, the liquid quantity of the liquid (infusion 82, chemical | medical solution 61, etc.) in the syringe 1 can be grasped | ascertained.
[0035]
In such an outer cylinder 2, a gasket 3 made of an elastic material is accommodated. A plurality of ring-shaped protrusions 31 and 32 are formed on the entire outer periphery of the gasket 3. By sliding the protrusions 31 and 32 in close contact with the inner peripheral surface 20 of the outer cylinder 2, the air tightness (liquid tightness) can be more reliably maintained and the slidability can be improved.
[0036]
In the present embodiment, two protrusions 31 and 32 are formed along the longitudinal direction of the gasket 3. That is, protrusions 31 and 32 are formed on the base end portion and the tip end portion of the gasket 3, respectively. Of these, the proximal end side of the protrusion 32 on the distal end side of the gasket preferably has a tapered surface whose outer diameter gradually increases toward the distal end.
[0037]
In the present invention, the position and number of the protrusions 31 and 32, the cross-sectional shape, and the like are not limited thereto.
[0038]
Further, the gasket 3 is formed with a hollow portion 33 opened to the base end surface thereof. In the hollow portion 33, a head portion of a pusher 4 described later is inserted (screwed). A female screw 34 is formed on the inner surface of the hollow portion 33.
[0039]
The constituent material of the gasket 3 is not particularly limited. For example, various rubber materials such as natural rubber, butyl rubber, isoprene rubber, butadiene rubber, styrene-butadiene rubber, silicone rubber, polyurethane, polyester, polyamide, Examples thereof include elastic materials such as various thermoplastic elastomers such as olefins and styrenes, or mixtures thereof.
[0040]
The gasket 3 only needs to have at least an outer peripheral portion made of the elastic material as described above. For example, the gasket 3 has a core portion (not shown) made of a resin material. The thing of the structure by which the elastic material is arrange | positioned so that it may cover may be used. In this case, the female screw 34 is formed in the core part.
[0041]
The gasket 3 is connected (attached) with a pusher 4 for moving the gasket 3 in the longitudinal direction within the outer cylinder 2.
[0042]
The pusher 4 has a main body portion 40 having a rod shape, preferably a round bar shape, and a flange-like (plate-like) finger contact portion 45 is formed at the base end of the main body portion 40. The pusher 4 is moved in the distal direction by pressing the finger rest 45 with a finger or the like.
[0043]
The main body 40 has a close contact sliding portion 41 whose outer peripheral surface slides while being in close contact with protrusions 52 and 53 of the sealing member 5 described later. The contact sliding portion 41 has a solid round bar shape (or a hollow round bar shape) with a circular cross section.
[0044]
Further, on the proximal end side of the main body portion 40 with respect to the close sliding portion 41, a ventilation portion 42 is formed which allows ventilation of a second space 92 described later and outside air. The ventilation part 42 is configured by a groove (slit) extending along the longitudinal direction of the main body part 40. In the present embodiment, three grooves are formed along the circumferential direction of the main body portion 40, but the number of grooves and the positions where they are formed are not limited thereto.
[0045]
A head portion (connecting portion) 43 that is inserted into the hollow portion 33 of the gasket 3 and connected to the gasket 3 is formed on the distal end side of the main body portion 40.
[0046]
On the outer periphery of the head portion 43, a male screw 44 that can be screwed with the female screw 34 on the inner surface of the hollow portion 33 is formed. The male screw 44 and the female screw 34 are screwed together to connect the gasket and the pusher 4 (see FIG. 2).
[0047]
As a constituent material of the pusher 4, for example, polyvinyl chloride, polyethylene, polypropylene, polystyrene, poly- (4-methylpentene-1), polycarbonate, acrylic resin, acrylonitrile-butadiene-styrene copolymer, polyethylene terephthalate, Various resins such as polyesters such as polyethylene naphthalate, butadiene-styrene copolymers, and polyamides (for example, nylon 6, nylon 6,6, nylon 6,10, nylon 12) can be mentioned. Among them, molding is easy. And a resin such as acrylic resin, polyester, and poly- (4-methylpentene-1) is preferable in that it has gas impermeability (gas barrier property).
[0048]
As described above, since the gasket 3 and the pusher 4 are connected by a screwed structure (an example of a mechanism having no play), the connection can be reliably performed. 3 and the pusher 4 are not detached, and the pusher 4 can be easily attached to and detached from the gasket 3.
[0049]
In the present invention, the connection structure between the gasket 3 and the pusher 4 may be a mechanism other than screwing, for example, a mechanism that does not have any play such as adhesion, fusion, or the like, or A mechanism with play such as loose fitting may be used.
[0050]
A sealing member 5 that seals the proximal end opening of the outer cylinder 2 is attached to the proximal end side of the outer cylinder 2. The sealing member 5 is entirely made of an elastic material and has a substantially cylindrical main body 50. An insertion hole 51 through which the main body 40 of the pusher 4 is inserted is formed at the center of the main body 50. A flange-shaped (plate-shaped) fixing portion 54 is formed on the outer peripheral portion of the main body 50 of the sealing member 5.
[0051]
A plurality (two) of ring-shaped protrusions 52 and 53 projecting from the inner surface of the insertion hole 51 toward the center part are formed on the inner periphery of the insertion hole 51 over the entire circumference. Since the protrusions 52 and 53 are in close contact with the outer peripheral surface of the close contact sliding portion 41 of the pusher 4, the airtightness of the second space 92 can be maintained, and the slidability of the pusher 4 is also improved. improves.
[0052]
In the present embodiment, the two protrusions 52 and 53 are formed along the axial direction of the insertion hole 51 of the sealing member 5, but the position and number of protrusions, the cross-sectional shape, and the like are limited to this. It is not something.
[0053]
In such a sealing member 5, the main body portion 50 is fitted into the proximal end opening of the outer cylinder 2 so that the outer peripheral surface of the main body portion 50 is in close contact with the inner peripheral surface 20 of the outer cylinder 2 and the outer edge portion of the fixing portion 54. Is sandwiched and fixed by the locking portion 28, so that the distal end surface of the fixing portion 54 comes into close contact with the proximal end surface of the flange 27 (see FIG. 2). Further, as described above, the protrusions 52 and 53 of the sealing member 5 are in close contact with the close contact sliding portion 41 of the pusher 4. Thereby, the base end opening of the outer cylinder 2 can be sealed almost airtight, and the airtightness of the second space 92 is maintained.
[0054]
The sealing member 5 also has a function of preventing the gasket 3 from coming off from the outer cylinder 2.
[0055]
And by installing such a sealing member 5, the sterility in the outer cylinder 2 can be maintained at a higher level. Further, when the syringe 1 is assembled, even if the syringe 1 is packaged in a non-sterile environment after the pusher 4 is mounted, the sterility of the syringe can be maintained, so that the sterility of the packaging process is not required. There is also an advantage that it is advantageous.
[0056]
The constituent material of the sealing member 5 is not particularly limited. For example, various rubber materials such as natural rubber, butyl rubber, isoprene rubber, butadiene rubber, styrene-butadiene rubber, silicone rubber, polyurethane, polyester, polyamide Examples thereof include various thermoplastic elastomers such as olefins, olefins, and styrenes, or elastic materials such as a mixture thereof. Among these, as a material having gas impermeability (gas barrier properties), for example, butyl rubber or styrene-butadiene rubber is preferably used for all or part of the sealing member 5.
[0057]
As shown in FIG. 2, the gasket 3 is positioned in the middle of the outer cylinder 2 in the longitudinal direction before the syringe 1 is used. Further, the close contact sliding portion 41 of the pusher 4 is located in the insertion hole 51 of the sealing member 5, and the ventilation portion 42 is located on the proximal side from the insertion hole 51. Thus, a first space 91 surrounded by the outer cylinder 2 and the gasket 3 is formed on the distal end side of the gasket 3, and the outer cylinder 2, the gasket 3, and the sealing member 5 are formed on the proximal end side of the gasket 3. A second space 92 surrounded by is formed. The first space 91 and the second space 92 are both decompressed.
[0058]
In the syringe 1, since the gasket 3 is located in the middle of the longitudinal direction of the outer cylinder 2, a part of the pusher 4 is inserted into the outer cylinder 2, and as a result, the syringe 1 before use. Can be made shorter. The fact that the total length of the syringe 1 is short is convenient for transportation, storage, etc. of the syringe 1.
[0059]
Considering this, there is a preferable range for the volume ratio between the first space 91 and the second space 92. That is, when the volume of the first space 91 is V ₁ and the volume of the second space 92 is V ₂ , V ₂ / V ₁ is preferably 0.3 to 50, and preferably 1 to 50. Is more preferable.
[0060]
When V ₂ / V ₁ is less than 0.3, the position of the gasket 3 in the outer cylinder 2 is relatively on the proximal end side, and the effect of shortening the overall length of the syringe 1 is reduced.
[0061]
Further, if V ₂ / V ₁ exceeds 50, a space for storing the medicine 6 cannot be secured sufficiently, and the amount of the medicine 6 to be stored may be restricted, and in the operation shown in FIG. May not be smoothly implemented.
[0062]
Both the first space 91 and the second space 92 are in a reduced pressure state, but the pressures in both the spaces 91 and 92 may be the same or different.
[0063]
When the pressure of the first space 91 is P ₁ [atmospheric pressure] and the pressure of the second space 92 is P ₂ [atmospheric pressure], P ₂ / P ₁ is preferably 0.2 to 5, 0.5 to 2 is preferred.
[0064]
When P ₂ / P ₁ is less than 0.2, high airtightness is required for the gasket 3, and the room for selecting the material of the gasket 3 is narrowed. Further, the pusher 4 may move before use.
[0065]
On the other hand, when P ₂ / P ₁ exceeds 5, similarly, high airtightness is required for the gasket 3, and the material selection for the gasket 3 is narrowed. Further, the pusher 4 may move before use. Furthermore, after the value of P ₂ becomes relatively high (close to atmospheric pressure), the membrane 24 is pierced by the needle tip 73 and the infusion 82 is introduced into the first space 91, the gasket 3 is moved in the proximal direction. There is a risk that the power to perform will be insufficient.
[0066]
Note _{that the} value of P 1, _{P 2} is not particularly limited, for example, _{P 1} and _{P 2,} respectively, may be 0.05 to 0.5 [pressure] degree.
[0067]
In the syringe 1 of the present embodiment, the medicine 6 is stored in advance in the first space 91 (see FIG. 2).
[0068]
The drug 6 may be liquid or solid, but is preferably a solid, and particularly preferably a powder (granular) solid. Examples of the powdered material include a lyophilized product. Moreover, such a powdery thing may be solidified into the tablet shape, for example.
[0069]
Specific examples of such a drug 6 include vitamins (general vitamins), various amino acids, antithrombotics such as heparin, insulin, antibiotics, antitumor agents, analgesics, cardiotonics, intravenous anesthetics, anti Examples include Parkinson's agent, ulcer treatment agent, corticosteroid agent, arrhythmia agent, correction electrolyte and the like. Needless to say, the present invention is not limited to these examples.
[0070]
In addition, in the syringe 1 before use, you may cover the whole or a part of syringe 1 with films (not shown) made from resin. Thereby, the airtightness of the syringe 1 becomes higher, and the decompressed state of the first space 91 and the second space 92 can be maintained at a higher level.
[0071]
Next, based on FIGS. 2-7, an example of the usage method of the syringe 1 is demonstrated. The method described below is an example in which a syringe with a double-ended needle is connected to the syringe 1 and a drug solution is mixedly injected into the infusion container.
[0072]
As shown in FIG. 3, the holder 7 connected to the syringe 1 includes a bottomed cylindrical holder body 71, a double-ended needle (needle tube) 72 having sharp needle points 73 and 74 at both ends, and a double-ended needle 72. And a hub (support member) 75 for supporting the. The double-ended needle 72 is fixed to a hub 75, and the hub 75 is attached to the center of the bottom of the holder body 71 by screwing.
[0073]
The infusion container 8 has a bottle shape or a bag shape, and an infusion solution 82 is housed in a liquid-tight manner inside. A stopper 81 made of an elastic material is attached to the mouth of the infusion container 8. With the stopper 81, the infusion container 8 is sealed in a liquid-tight manner.
[0074]
The plug body 81 can be pierced by a double-ended needle 72 or other needle tube such as a bottle needle. When the needle tube is pulled out, the piercing hole is closed due to self-occlusion and ensures liquid tightness.
[0075]
[1] The holder 7 and the infusion container 8 as described above are prepared. First, the needle tip 74 of the holder 7 is pierced through the stopper 81 of the infusion container 8 (see FIG. 3).
[0076]
Next, the holder main body 71 of the holder 7 is fitted (covered) on the cap 25 of the syringe 1. As a result, the needle tip 73 penetrates the membrane 24 and enters the lumen 23 of the reduced diameter portion 22 (see FIG. 3). In this state, the first space 91 of the syringe 1 and the internal space of the infusion container 8 communicate with each other via the double-ended needle 72.
[0077]
[2] When the first space 91 of the syringe 1 and the internal space of the infusion container 8 communicate with each other, the first space 91 is in a reduced pressure state, so that the infusion in the infusion container 8 passes through the double-ended needle 72. Are sucked and introduced into the space 91 (see arrows in FIG. 3).
[0078]
When the infusion 82 flows into the first space 91, the pressure in the first space 91 increases, and the differential pressure with respect to the second space 92 gradually increases. Due to this differential pressure, the gasket 3 receives a force in the proximal direction and automatically moves in the proximal direction. As the gasket 3 moves, the infusion 82 in the infusion container 8 is further sucked and introduced into the first space 91 via the double-ended needle 72 (see FIG. 4).
[0079]
When the gasket 3 moves in the proximal direction, the pusher 4 slides while the surface of the close contact sliding portion 41 is in close contact with the protrusions 52 and 53 of the sealing member 5. Almost no air flows into the second space 92.
[0080]
[3] When the movement of the gasket 3 is stopped, the syringe 1 is shaken or vibrated to dissolve or disperse the drug 6 in the infusion solution 82 introduced into the first space 91, and the drug solution 61 containing the active ingredient of the drug 6. (See FIG. 5). In addition, as the chemical | medical solution 61, the melt | dissolution solution, suspension (emulsion), etc. of the chemical | medical agent 6 are mentioned.
[0081]
Further, if necessary, the syringe 1 may be temporarily detached from the holder 7 (the fitting between the cap 25 and the holder main body 71 is released), and then an operation of swinging or vibrating the syringe 1 may be performed.
[0082]
[4] A finger is applied to the finger contact portion 45 of the pusher 4 to press the pusher 4 in the distal direction. Thereby, the chemical | medical solution 61 in the 1st space 91 is discharged | emitted through the double-ended needle 72, and is mix | blended with the infusion solution 82 of the infusion container 8 (refer FIG. 6).
[0083]
The pressing movement of the pusher 4 is performed until the tip surface 35 of the gasket 3 comes into contact (or approaches) the bottom 21 of the outer cylinder 2 (see FIG. 7). Thereby, the residual liquid amount in the syringe 1 of the chemical | medical solution 61 can be decreased as much as possible, and the chemical | medical solution 61 can be mix | blended without waste.
[0084]
As the second space 92 increases as the gasket 3 moves in the distal direction due to the pressing of the pusher 4, the pressure in the second space 92 gradually decreases. However, when the tip surface 35 of the gasket 3 moves to a position where it contacts (or approaches) the bottom 21 of the outer cylinder 2, the ventilation portion 42 formed in the pusher 4 is inserted into the insertion hole 51 of the sealing member 5. Then, outside air flows into the second space 92 through the ventilation portion 42 (see FIG. 7). Thereby, since the second space 92 is in an atmospheric pressure state, the gasket 3 does not move in the proximal direction even if the finger is released from the pusher 4 to release the pressing force.
[0085]
[5] When a medicine having different components is further blended in the infusion container 8, the syringe 1 is removed from the holder 7 while the needle tip 74 of the double-ended needle 72 is pierced through the stopper 81, and a new blending is attempted. The same syringe 1 containing the medicine is set in the holder 7 in the same manner as in [1], and the same operations as in [2] to [4] are performed. As described above, when a plurality of types of drugs having different components are blended, a plurality of syringes 1 in which the respective drugs are stored may be prepared and used by appropriately replacing them. Therefore, the operation is extremely simple. The time required for blending is also short. The order of blending can also be arbitrarily selected. Furthermore, in such a chemical formulation, there is very little opportunity to come into contact with the outside air, and there is no risk of bacterial contamination or contamination.
[0086]
As can be seen from the operations [1] to [5], in the syringe 1 of the present invention, the operation of pulling the pusher 4 does not have to be performed when the chemical solution is blended. And the operation which pushes the pusher 4 may be one time. Therefore, the operation is simple and can be operated with one hand.
[0087]
Although the illustrated embodiment of the syringe of the present invention has been described above, the present invention is not limited to this. In particular, the structure of the pusher, the structure of the gasket, the structure of the sealing member, and the like are not limited to the illustrated structure, and can be any structure that can exhibit the same function.
[0088]
【The invention's effect】
As described above, according to the prefilled syringe of the present invention, medicine can be blended without performing the operation of pulling the pusher, and the operation is extremely simple.
[0089]
Moreover, since the full length of the prefilled syringe before use can be shortened, it is small and convenient for transportation, storage and the like.
Moreover, the inside aseptic maintenance is high, and it is excellent also in terms of hygiene and safety.
[0090]
Further, when the vent is provided in the pusher, the pusher can be prevented from returning after the liquid is discharged.
[Brief description of the drawings]
FIG. 1 is a longitudinal sectional view showing an embodiment (disassembled state) of a prefilled syringe of the present invention.
FIG. 2 is a partial longitudinal sectional view showing an embodiment (assembled state) of the prefilled syringe of the present invention.
FIG. 3 is a longitudinal sectional view showing an operating state when the prefilled syringe shown in FIGS. 1 and 2 is used.
FIG. 4 is a longitudinal sectional view showing an operating state when the prefilled syringe shown in FIGS. 1 and 2 is used.
FIG. 5 is a longitudinal sectional view showing an operating state when the prefilled syringe shown in FIGS. 1 and 2 is used.
6 is a longitudinal sectional view showing an operating state when the prefilled syringe shown in FIG. 1 and FIG. 2 is used.
FIG. 7 is a longitudinal sectional view showing an operating state when the prefilled syringe shown in FIGS. 1 and 2 is used.
[Explanation of symbols]
1 Syringe (Prefilled syringe)
2 Outer cylinder 20 Inner peripheral surface 21 Bottom portion 22 Reduced diameter portion 23 Lumen 24 Membrane 25 Cap 26 Opening 27 Flange 28 Locking portion 29 Scale 3 Gasket 31 Protrusion portion 32 Protrusion portion 33 Hollow portion 34 Female screw 35 Tip surface 36 Base end surface 4 Pusher 40 Main Body 41 Adhesive Sliding Part 42 Ventilation Part (Groove)
43 Head portion 44 Male screw 45 Finger rest portion 5 Sealing member 50 Main body portion 51 Insertion hole 52 Protrusion portion 53 Protrusion portion 54 Fixing portion 55 Tip surface 6 Drug 61 Drug solution 7 Holder 71 Holder main body 72 Double-headed needle 73 Needle tip 74 Needle tip 75 Hub 8 Infusion container 81 Plug body 82 Infusion 91 First space 92 Second space

Claims (5)

A bottomed cylindrical outer tube having a mouth part through which liquid can enter and exit on the tip side;
A gasket that is arranged in the outer cylinder and slides with its entire circumference in close contact with the inner peripheral surface of the outer cylinder;
A pusher connected to the gasket and moving the gasket in the longitudinal direction of the outer cylinder;
A sealing member that seals the proximal end opening of the outer cylinder and has an insertion hole for inserting the pusher;
Fixing means for fixing the sealing member to the base end portion of the outer cylinder and immobilizing the sealing member;
A prefilled syringe comprising a medicine housed in a first space surrounded by the outer cylinder and the gasket located on the distal end side of the gasket,
The pusher has a close sliding portion that slides while its outer peripheral surface is in close contact with at least a part of the insertion hole,
The second space surrounded by the outer cylinder, the gasket and the sealing member located on the base end side of the gasket, and the first space are respectively in a reduced pressure state,
A portion of the pusher is inserted through the second space in a reduced pressure state ;
When the liquid flows into the first space from the mouth and the pressure in the first space increases and the differential pressure with the second space increases, the differential pressure causes the gasket to The prefilled syringe is configured so that the gasket and the pusher connected to the gasket are automatically moved in the proximal direction in response to a force in a direction .   A vent portion is provided on the proximal end side of the contact sliding portion of the pusher, and air is introduced into the second space through the vent portion so that the decompressed state of the second space is released. The prefilled syringe according to claim 1 which is constituted.   The prefilled syringe according to claim 2, wherein the ventilation portion is configured by a groove formed on an outer peripheral surface of the pusher. Wherein _{V 1} to the volume of the first space, wherein, when the volume of the second space and a _{V 2,} prefilled according to any one of claims 1 to 3 V 2 / _{V 1} is 0.3 to 50 Syringe. 5. The pressure of P ₂ / P ₁ is 0.2 to 5 when the pressure of the first space is P ₁ [atmospheric pressure] and the pressure of the second space is P ₂ [atmospheric pressure]. The prefilled syringe in any one.

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