JP4253296B2 - Health beauty food - Google Patents

Description

  The present invention relates to a health beauty food. More specifically, it is particularly effective in preventing, improving, and recovering from, for example, aging, fatigue, liver dysfunction, blood circulation disorder, hypertension, arteriosclerosis, joint disorders, diabetes, low back pain, stiff shoulders, and coldness. The present invention relates to health and beauty foods that also have beauty effects such as prevention, improvement, recovery, skin beautification, antioxidant and anti-pollution effects.

  In recent years, consumer interest in so-called lifestyle-related diseases has been increasing, and in response to this, development of various health foods and health drinks has been promoted.

  For example, a tableted health food containing citric acid, which has been the focus of attention as having been effective for blood pressure adjustment, obesity prevention, arteriosclerosis prevention, and the like, and further containing chitin chitosan, calcium, flavonoids, riboflavin, and polyphenols. It has been proposed (see, for example, Patent Document 1).

  In addition, salmon cartilage mainly composed of proteins such as collagen that activates metabolism and prevents aging, and mucopolysaccharides such as chondroitin sulfate that enhances biological defense functions such as anticancer effects, has been used in health foods and health drinks. For example, there has been proposed a health drink mainly composed of an extract obtained by ionizing the shark cartilage and a ginkgo biloba extract (for example, see Patent Document 2).

  Furthermore, for the purpose of improving liver function and preventing liver dysfunction such as liver disease, various herbal medicines that have been used as traditional treatments for liver diseases in India and China since ancient times are combined. Focusing on the use, for example, health foods containing extracts or dried products of six kinds of medicinal plants consisting of Maria thistle, turmeric, ginseng, licorice, red ginseng, and ebisu are proposed (for example, (See Patent Document 3).

  As described above, since various active ingredients used in conventional health foods have specific effects, these conventional health foods are combined with several active ingredients that exhibit similar effects. The majority have been done. Therefore, in order to cope with various lifestyle-related diseases of the present day, it is necessary to take a variety of health foods in a well-balanced combination, which is not only cumbersome, but when combining multiple health foods, On the other hand, there is a risk that the effects of each other may be offset, and sufficient care is required for the combination.

Also, especially among women, there is a high interest in beauty foods and beverages that prevent and improve rough skin, fine wrinkles, etc., and maintain moisture and tension of skin over a wide age group. Many consumers ingest with health food. As a result, the combination of these beauty foods and health foods requires more caution and may continue to be ingested over a relatively long period of time. Development is awaited.
JP 11-346711 A JP 2000-354476 A JP 2003-135023 A

  The present invention has been made in view of the background art, there is no complexity at the time of ingestion, and various excellent effects that can cope with various modern lifestyle diseases are synergistically expressed in a balanced manner, Furthermore, it aims at providing the health beauty food which also expresses a beauty effect.

That is, the present invention comprises citric acid 35 to 75% by weight , turmerics 5 to 50% by weight , α-lipoic acid 0.1 to 15% by weight , hyaluronic acid 0.1 to 15% by weight and collagen 1 to 30% by weight. The present invention relates to a health beauty food containing active ingredients formulated in proportions . Citric acid as an active ingredient, turmeric acids, alpha-lipoic acid, five hyaluronic acids and collagen, at the same time, a major feature of it is the invention formulated in a specific ratio, specific five thus The health beauty food of the present invention containing an active ingredient with a specific ratio of ingredients is, for example, aging, fatigue, liver dysfunction, blood circulation disorder, hypertension, arteriosclerosis, joint disorder, diabetes, low back pain, stiff shoulder, coldness It is particularly effective for prevention, improvement, and recovery of skin, and it also exhibits beauty effects such as prevention, improvement, recovery of skin and wrinkles, and beauty and skin effects, as well as anti-oxidation and anti-contamination effects. It is possible to obtain a beauty effect at the same time while preventing, improving, and recovering from these lifestyle-related diseases without ingesting food and beauty foods at the same time.

  Citric acid extract as citric acid, autumn turmeric as turmeric, a racemic mixture of D-isomer and L-isomer as α-lipoic acid, a complex of hyaluronic acid and protein as hyaluronic acid, particularly When the chicken crown extract is a collagen derived from fish as a collagen, especially a fish skin extract, the prevention, improvement, recovery and beauty effects of the lifestyle-related diseases are further improved.

Further, the active ingredients are 40 to 70% by weight of citric acid , 10 to 45% by weight of turmerics , 0 . 5-10 wt%, hyaluronic acid compounds 0. 5-10 wt%, and when it is blended in an amount of collagen 2-25% by weight, the effect of each component leads, efficacy is better expressed, increasingly synergistic effect is further prevention of the lifestyle-related disease , Improvement, recovery effect and beauty effect are further improved.

  In addition to the active ingredient, excipients, particularly sucrose fatty acid esters, for example, 0.5 to 5 parts by weight, further 1 to 3 parts by weight with respect to 100 parts by weight of the active ingredient, For example, preparation in the form of a tablet or the like can be performed more easily.

  The health beauty food of the present invention is particularly effective in preventing, improving, and recovering, for example, aging, fatigue, liver dysfunction, blood circulation disorder, hypertension, arteriosclerosis, joint disorders, diabetes, low back pain, stiff shoulders, coldness, etc. It also has beauty effects such as spots, wrinkles prevention, improvement, recovery, skin beautification, antioxidant and anti-contamination effects. Therefore, excellent health and beauty foods that are not complicated during ingestion and that are capable of coping with various lifestyle-related diseases of the present day, and that various excellent effects are synergistically expressed in a balanced manner, and also have cosmetic effects. It is.

(First embodiment)
The health beauty food of the present invention contains an active ingredient containing citric acid, turmeric, α-lipoic acid, hyaluronic acid and collagen. First, these active ingredients will be described below.

  Citric acid is a kind of hydroxy acid, and is a component mainly having effects such as blood pressure adjustment and arteriosclerosis prevention in addition to fatigue recovery effect. It is thought that citric acid exhibits such an effect because it acts in the body as follows.

  For example, when starch is ingested, starch changes from glucose to pyrogenic acid and is taken into the citric acid cycle. When you move your body, you need oxygen and vitamin B1 to turn the citric acid cycle, so you have to breathe and take oxygen to turn the cycle. However, when the rotation of the citric acid cycle becomes dull, the incorporated pyrogenic acid cannot be digested, and undigested pyrogenic acid becomes lactic acid and accumulates in the tissue. Since tissue is a protein, when lactic acid, which is an acid, accumulates in the arms and shoulders, it causes stiff shoulders, and when it accumulates throughout the body, it feels tired.

  When citric acid is ingested here, it reacts with alkaline sodium hydrogen carbonate in pancreatic juice, and citric acid produces alkaline sodium citrate. The action of sodium citrate softens muscles and tissues that have been hardened with lactic acid, recovers fatigue, and calcium ions in the blood are chelated to reduce blood concentration, compressing capillaries The blood pressure is restored to normal and arteriosclerosis can be prevented.

  Citric acid used in the present invention includes, for example, citrus extracts such as lemon, lime, summer tangerine, and fermented starches such as sweet potato and sugar cane. Among these, recovery from fatigue, adjustment of blood pressure, prevention of arteriosclerosis Citrus extract is particularly preferably used because it has a great effect on the water and is easy to handle. Moreover, the form is usually powdery, and a citric acid crystal containing about 0.5% water is preferable. In addition, in this invention, 1 type may be used individually as this citric acid, and 2 or more types may be mixed and used for it.

The amount of citric acid is 35% by weight or more, preferably 40% by weight or more of the total amount of the active ingredients so that the effects of recovery from fatigue, adjustment of blood pressure, prevention of arteriosclerosis and the like can be fully expressed. Oh Ru. In consideration of the blending ratio with other active ingredients such as turmeric, α-lipoic acid, hyaluronic acid and collagen, the citric acid content is 75% by weight or less, preferably 70% by weight or less of the total amount of the active ingredients. Oh Ru.

  Turmerics are perennials belonging to the genus Curcuma, a Chinese medicine, a component that mainly has the effect of preventing, recovering and improving liver dysfunction such as liver disease, and also cleansing blood and stomach It is a component that has an effect on the action, recovery of stomach sag and gastritis. About 50 kinds of turmerics are currently recognized, and examples of components contained in these turmerics include curcumin, turmerone, cineol, α-curcumene, curcumol, β-elemene, p-methytoyl cappinol, azulene, In addition to camphor, over 1000 types are recognized. Examples of turmerics used in the present invention include spring turmeric, autumn turmeric, purple turmeric, and the like, which are classified as Chinese medicine tops.

  Spring turmeric (namely herbal medicine) has a low curcumin content, but it contains a lot of essential oil components and minerals such as cineole, turmerone, α-curcumene, and curcumol, and in addition to the effects on liver dysfunction, cleansing action of blood and stomach It is a component having Autumn turmeric (herbal medicine name: turmeric) is a component that contains a large amount of curcumin, promotes the secretion of bile and improves the function of the liver, and has a great effect on the prevention, recovery, and improvement of liver dysfunction. Purple turmeric (herbal medicine name: Gajutsu) contains many essential oil components such as cineole, camphor, and azulene, and has an effect on the recovery of stomach sag and gastritis. Among these, autumn turmeric is particularly preferably used because it has a great effect on prevention, recovery and improvement of liver dysfunction and is easy to handle. Moreover, it is preferable that the form is usually a powder of rhizome or bulb. In the present invention, as the turmerics, one kind may be used alone, or two or more kinds may be mixed and used.

The amount of turmeric compound is an active ingredient in order to sufficiently prevent the liver dysfunction caused by such turmeric, recover it, improve it, cleanse the blood, stomach, stomach sag, and gastritis. total amount 5 wt% or more, preferably Ru der 10 wt% or more. In consideration of the blending ratio with other active ingredients such as citric acid, α-lipoic acid, hyaluronic acid and collagen, the amount of turmeric is 50% by weight or less, preferably 45% by weight or less of the total amount of active ingredients. Oh Ru.

  α-Lipoic acid (thioctic acid) is a compound with a five-membered ring containing a disulfide bond and an asymmetric center. There are D and L stereoisomers, mainly preventing aging, improving recovery and improving blood circulation disorders. It is a component having an effect.

  α-Lipoic acid is a component contained in meat such as vegetables and liver such as potato, spinach, broccoli, tomato, carrot, etc., but functions as a cofactor of energy production reaction essential for life support in the body, It is a component that also functions as an antioxidant. The biosynthesis of α-lipoic acid in the body is considered to be carried out in mitochondria using octainoic acid and L-cysteine as raw materials. Therefore, effective intake of α-lipoic acid is required.

  It is considered that α-lipoic acid exhibits the effects of preventing and recovering aging and improving blood circulation disorders in the body as follows.

  In the process of the cell's mitochondria producing energy in the body, a by-product called active oxygen is generated. This active oxygen not only attacks the mitochondrial wall, but also attacks the membrane of the cell itself, attacks the genetic material DNA, and causes cancer development and proliferation. In addition to oxidizing lipids in the blood and causing arteriosclerosis, it also causes age-related diseases such as arthritis and cataracts, which accelerates aging.

  Here, the amount of this active oxygen is controlled by the action of an antioxidant network containing α-lipoic acid, and the active oxygen is eliminated before the tissues and cells are attacked. In addition, α-lipoic acid activates other antioxidants to improve its effect and improve sustainability. Moreover, since α-lipoic acid acts inside and outside the cell membrane, it exhibits antioxidant effects throughout the body, and is an important water-soluble antioxidant produced in the body that remains intact when ingested from the outside. It is also possible to increase the concentration of glutathione that is difficult to take into the blood in a form.

  Examples of α-lipoic acid used in the present invention include D-isomer, L-isomer, racemic mixture of D-isomer and L-isomer, sodium salt, potassium salt, alkyl ester, alkenyl. Examples include esters, amides, and reductants such as dihydrolipoic acid and dihydrolipoamide. Among these, D has a great effect on prevention, recovery and improvement of blood circulation disorder, and is easy to handle. A racemic mixture of -isomer and L-isomer is particularly preferably used. The form is, for example, a crystal powder or a platelet crystal, and the particle size is preferably about 400 to 600 μm. In the present invention, one kind of α-lipoic acid may be used alone, or two or more kinds may be mixed and used.

The blending amount of α-lipoic acid is 0.1% by weight or more of the total amount of active ingredients in order to prevent the aging caused by such α-lipoic acid, and to fully exhibit the effect of recovery and improvement of blood circulation disorder, preferably Ru der least 0.5 wt%. In consideration of the blending ratio with other active ingredients such as citric acid, turmeric, hyaluronic acid and collagen, the blending amount of α-lipoic acid is 15% by weight or less, preferably 10% by weight or less of the total amount of the active ingredients. Oh Ru.

  Hyaluronic acids are hyaluronic acid and a substance containing the hyaluronic acid, and are mainly components having a skin beautifying effect that enhances joint damage prevention, recovery and moisturizing power.

  Hyaluronic acid is a kind of mucopolysaccharide, which is present in all vertebrates as a component of the extracellular matrix, particularly in the skin. The structure is composed of a disaccharide of D-glucuronic acid and N-acetyl-D-glucosamine as a repeating basic structural unit, which are linked by glycosidic bonds in which β-1,4 and β-1,3 are alternately repeated. A linear continuous structure. Hyaluronic acid is usually a polymer having an average molecular weight of about 500,000 to 5,000,000, and this level can also be used in the present invention. However, in order to improve the absorption rate into the body, the molecular weight is reduced. You can also use what you did.

  Although it is not certain that hyaluronic acid exhibits the effects of preventing joint damage, enhancing recovery and enhancing moisturizing power, for example, based on the network structure of hyaluronic acid, it has physical properties such as viscoelasticity or viscosity in vivo. It is thought that it may impart a shock-relaxing effect to the tissue in the joint, and a moisturizing effect to the skin based on the water retention ability of many hydroxyl groups in the molecule. This ability of synthesizing hyaluronic acid in the body, for example, decreases with age due to a decline in the action of the enzyme, and this also requires effective intake of hyaluronic acid.

  Examples of the hyaluronic acid used in the present invention include hyaluronic acid and a complex of hyaluronic acid and a protein such as collagen. Examples of the complex of hyaluronic acid and protein include chicken crown extract, elastin, Examples include ceramide. Of these, a complex of hyaluronic acid and protein, particularly a chicken crown extract, is preferably used because it has a great effect in preventing, recovering and improving the moisturizing power of joint disorders, and is easy to handle. In the case of a complex of hyaluronic acid and protein, the hyaluronic acid content is preferably about 5% or more. Moreover, it is preferable that the form is a powder form, for example. In the present invention, these hyaluronic acids may be used alone or in combination of two or more.

The blending amount of hyaluronic acid is 0.1% by weight or more of the total amount of the active ingredients, in order to prevent the joint damage caused by such hyaluronic acid, and to fully exhibit the skin beautifying effect that enhances the recovery effect and moisturizing power, preferably Ru der 0.5% by weight or more. In consideration of the blending ratio with other active ingredients such as citric acid, turmeric, α-lipoic acid and collagen, the blending amount of hyaluronic acid is 15% by weight or less, preferably 10% by weight or less of the total amount of active ingredients. Oh Ru.

  Collagen is a protein that exists in skin, bones, tendons and the like and is important for metabolism of the body, and is a component having a beautifying effect that mainly prevents skin aging. Collagen has a polypeptide chain with a triple helix structure. About one third of the constituent amino acids are glycine, and about 10% of hydroxyproline is produced by modifying proline during the synthesis process. It is.

  It is considered that collagen exerts a skin beautifying effect that prevents skin aging because it acts in the body as follows.

  The decline in metabolism of the proteins that make up the body is the cause of aging, but the environment surrounding the cells activates the metabolism of the cells themselves, and collagen plays a more important role at that time. Therefore, when the metabolism of collagen in the dermis, which is the essence of the skin, of the epidermis, dermis, and subcutaneous tissue that make up the skin declines, unnatural cross-linking between the collagens increases, and the part that retains moisture through this cross-linking As a result, the moisturizing effect is reduced and skin aging progresses.

  If collagen is ingested here and the metabolism of the dermis is activated, the increase in unnatural cross-linking of collagen can be prevented, and the ability to retain moisture is not reduced, preventing skin aging. . The synthetic function of the collagen in the body decreases with age, for example, and this also requires effective intake of collagen.

  Examples of the collagen used in the present invention include fish-derived collagen, meat-derived collagen, and the like. Fish-derived collagen is particularly preferably used because it is excellent in the action of activating metabolism of the dermis and is easily available.

  Examples of the fish-derived collagen include fish skin extract, fish bone extract, fish scale extract, etc., and among these, it is excellent in the action of activating metabolism of the dermis and has a large effect of preventing skin aging. From the standpoint, fish skin extract is preferred. The raw fish is not particularly limited, and for example, skipjack, tuna, cod, and salmon can be used as appropriate. In the present invention, one type of collagen may be used alone, or two or more types may be mixed and used.

  Collagen is usually a polymer having an average molecular weight of about 100,000, and can be used in the present invention as well. However, in order to further improve the absorption rate into the body, the enzyme is decomposed and the average molecular weight is, for example, Those having a low molecular weight of about 1000 to 10,000 are preferably used.

The amount of collagen, to ensure beautiful skin effect of preventing skin aging by such collagen is sufficiently expressed, the active ingredient total amount 1 wt% or more, preferably Ru der 2% by weight or more. Considering the blending ratio with other active ingredients such as citric acid, turmeric, α-lipoic acid and hyaluronic acid, the blending amount of collagen is 30% by weight or less, preferably 25% by weight or less of the total amount of active ingredients. Oh Ru.

  In addition, the said active ingredient adjusts suitably the mixture ratio of a citric acid, turmeric, (alpha) -lipoic acid, hyaluronic acid, and collagen so that the compounding quantity of each of these components may each be in a preferable range, and 100 weight% in total quantity What should be done.

  The health beauty food of the present invention contains an active ingredient in which five kinds of ingredients are mixed as described above, and the active ingredient itself can be ingested in a desired form. For example, in order to further improve the formulation, it is possible to contain a small amount of an excipient as necessary.

  The excipient used in the present invention is not particularly limited and may be those usually used in health foods and beauty foods. Examples thereof include sucrose fatty acid ester, cellulose, lactose, pine fiber, dextrin, and paindex. These can be used alone or as a mixture of two or more. Of these, sucrose fatty acid esters are preferred because they are well-familiar with the active ingredient and easy to handle.

  Examples of the sucrose fatty acid ester include esters of sucrose and fatty acids such as stearic acid, palmitic acid, myristic acid, oleic acid, lauric acid, behenic acid, erucic acid, and the like. Can be used.

  The content of the excipient is 0.5 parts by weight or more with respect to 100 parts by weight of the active ingredient so that the effect of improving the formulation by using such an excipient can be fully expressed. Is preferably 1 part by weight or more. Further, in order not to disturb the expression of the effect of each active ingredient, the content of the excipient should be 5 parts by weight or less, further 3 parts by weight or less with respect to 100 parts by weight of the active ingredient. Is preferred.

  Furthermore, in the present invention, in addition to the above-mentioned excipients, for example, emulsifiers, sweeteners, brighteners, processing aids, colorants, preservatives, antioxidants, and additives contained in normal health foods and beauty foods. Components such as a viscosity stabilizer, a sour agent, and a surface coating agent can be optionally contained as long as the object of the present invention is not impaired.

  The method for producing the health and beauty food of the present invention is not particularly limited, and a normal method for producing health food and beauty food may be adopted. For example, it can be produced by the following method.

  First, procure raw materials such as active ingredients, and if necessary, excipients and other ingredients, and perform inspections such as sensory inspection, physical property inspection, and hygiene inspection, and then manage them at a predetermined temperature and humidity for a predetermined time. . Next, the active ingredient whose blending ratio has been adjusted, excipients as necessary, other ingredients, and the like are weighed and fed into a mixer to be uniformly mixed under conditions such as a predetermined temperature, humidity, and time. Then, the obtained raw material mixture is subjected to inspections such as sensory inspection and physical property inspection. For example, it may be formulated into various forms as shown below, and the obtained health beauty food may be subjected to final inspection such as sensory inspection, hygiene inspection, and component inspection.

  The form of the health beauty food of the present invention is not particularly limited, and can be various forms such as tablets, capsules, powders, granules, and liquids. For example, when it is set as a tablet, the method of tableting the raw material mixture obtained as mentioned above with a pressure type tableting machine is employable. Alternatively, after the raw material mixture is uniformly dispersed in the oil and fat, beeswax or the like may be added to adjust the viscosity of the slurry as appropriate, and the mixture may be filled into soft capsules mainly composed of gelatin and glycerin using a soft capsule filling machine. Furthermore, the raw material mixture may be granulated and used as it is as a powder or granule, and the obtained powder or granule may be filled into a hard capsule mainly composed of gelatin, bullulan and cellulose by a hard capsule filling machine.

  The intake amount of the health beauty food of the present invention varies somewhat depending on individual symptoms and physiques, but the effects of the present invention such as prevention, improvement, recovery effect and beauty effect of lifestyle-related diseases should be fully expressed. For example, the daily dose is preferably about 1000 to 5000 mg, more preferably about 1500 to 4000 mg, and usually it is preferably taken continuously every day.

  Next, although the health beauty food of the present invention is explained in detail based on an example, the present invention is not limited only to these examples.

Example 1
Each component shown below was prepared as an active ingredient. When the quality inspection of each component was conducted, all were qualified as ingredients for health and beauty foods.
(1) Lemon citrate extract (manufactured by Maruzen Pharmaceutical Industry Co., Ltd., colorless crystal to white crystalline powder,
Batch number 1069486)
Citric acid crystals: 99.85%
Moisture: 0.11%
The quality inspection results are shown in Table 1 below.

(2) Turmeric autumn turmeric rhizome (yellow powder)
Antioxidant Curcumin: About 3.6%
The quality inspection results are shown in Table 2 below.

(3) α-lipoic acid Lipoec (registered trademark, manufactured by Cognis Japan Co., Ltd.), pale yellow crystal powder,
Lot number 405I001)
α-Lipoic acid: 99.6%
6,8-epitrithiooctanoic acid (0.08%)
Particle size: less than 600 μm The quality inspection results are shown in Table 3 below.

(4) Hyaluronic acid HCP (trade name, hyaluronic acid for food, manufactured by Maruha Co., Ltd., slightly tan powder,
Lot number 0401)
Chicken crown extract (containing low molecular weight hyaluronic acid)
Hyaluronic acid: 5.7%
Protein (collagen etc.): 91%
The quality inspection results are shown in Table 4 below.

(5) Collagen Fish Collagen WP (trade name, manufactured by Maruha Corporation, white to pale yellow powder,
Lot number 0406291)
Fish skin extract (containing low molecular weight collagen)
Collagen: 94.9%
The quality inspection results are shown in Table 5 below.

The active ingredient, sucrose fatty acid ester (excipient, trade name: DK ester F20W, manufactured by Daiichi Kogyo Seiyaku Co., Ltd.), calcium phosphate (processing aid, tricalcium phosphate, manufactured by Rasa Soei Co., Ltd.), Reduced maltose starch syrup (sweetener), carnauba wax (brightening agent) and shellac (surface coating agent) were controlled at room temperature and normal humidity, and then weighed so that the blending ratios shown in Table 6 below were obtained.

  Ingredients other than the weighed shellac were fed into a powder mixer and uniformly mixed at room temperature and humidity for about 20 minutes. The resulting raw material mixture is granulated with a fluid granulator, then compressed with a pressure tablet machine, surface coated with shellac, and is a round tablet with a diameter of about 9 mm and 350 mg / tablet. A food was prepared.

  The obtained health beauty food was subjected to 3 tablets once a day and 3 times a day for one month continuously. As a result, it was confirmed that fatigue, lower back pain, stiff shoulders, coldness were recovered, blood circulation was improved, blood pressure was reduced to a normal value, wrinkles were reduced, and skin moisture was restored.

  The health beauty food of the present invention is particularly effective for the prevention, improvement and recovery of aging, fatigue, liver dysfunction, blood circulation disorder, hypertension, arteriosclerosis, joint disorders, diabetes, low back pain, stiff shoulders, coldness, etc. While dealing with various lifestyle-related diseases, in addition to preventing and improving spots, wrinkles, beauty effects such as recovery, skin beautification, anti-oxidation and anti-contamination effects, it can eliminate the complexity of ingestion it can.

Claims (1)

Citric acid 56% by weight, turmeric acids 29 wt%, alpha-lipoic acid 2 wt%, hyaluronic acid 2 wt% and collagen 11 wt% health beauty food comprising the active ingredient formulated in a proportion of.