JP4257002B2 - Oral composition - Google Patents

Description

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以上の実験結果から、本発明による練歯磨剤は経時安定性に優れ、且つ嗜好性、使用感についても優れていることが判る。また下記に示す実施例９〜２４の練歯磨剤についても上記の実験を行ったところ、全て上記と同様な結果が得られた。以下、実施例９〜２４の練歯磨剤の組成を示す。配合量の単位は質量％である。
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[0001]
BACKGROUND OF THE INVENTION
The present invention relates to a composition for oral cavity that is excellent in storage stability and excellent in palatability and use feeling.
[0002]
[Prior art]
Conventionally, it has been known to add an apatite such as hydroxyapatite to an oral composition such as a toothpaste, thereby providing a recalcification of tooth surfaces and an adsorption removal effect of dental plaque.
On the other hand, toothpastes containing apatites such as hydroxyapatite tend to be hard, have a rough appearance over time, cause liquid separation, and have a problem that sufficient storage stability cannot be obtained. In order to improve such stability over time, for example, a magnesium salt is proposed, but there is a problem that the palatability and feeling of use such as a rowing feeling and aftertaste are not sufficient.
Therefore, it is desired to improve palatability and feeling of use without impairing storage stability in an oral composition containing apatites.
[0003]
[Problems to be solved by the invention]
An object of the present invention is to provide an oral composition that exhibits excellent palatability and feeling of use without impairing storage stability while blending apatites.
[0004]
[Means for Solving the Problems]
As a result of intensive studies to solve the above problems, the present inventors have formulated a combination of magnesium salts and zeolites and / or hydrous aluminum silicates in oral compositions containing apatites. Thus, it has been found that an oral composition that does not become hard even when stored at a high temperature for a long period of time, maintains smoothness in appearance, does not cause liquid separation, and has excellent palatability and usability.
Therefore, the present invention is an oral composition containing at least one selected from the group consisting of hydroxyapatite, fluoroapatite, carbonate apatite, tricalcium phosphate, quaternary calcium phosphate and octacalcium phosphate, The present invention relates to an oral composition comprising 0.05 to 10% by mass of a magnesium salt and 0.1 to 20% by mass of at least one selected from the group consisting of zeolites and hydrous aluminum silicates.
[0005]
DETAILED DESCRIPTION OF THE INVENTION
Hereinafter, the present invention will be described in detail.
The oral composition in the present specification refers to dentifrices such as toothpastes and liquid dentifrices, troches, creams, ointments, attachments, mouthwashes, mouth fresheners, mouthwashes, chewing gum Or it includes gargle.
The apatite used in the present invention means hydroxyapatite, fluoroapatite, carbonate apatite, tricalcium phosphate, quaternary calcium phosphate, and octanoic calcium phosphate. In the present specification, hydroxyapatite, fluoroapatite, carbonate apatite, tricalcium phosphate, quaternary calcium phosphate and octacalcium phosphate are collectively referred to as apatites.
Each is represented by the following chemical formula.
Hydroxyapatite: Ca ₁₀ (PO ₄ ) ₆ (OH) ₂
Fluoroapatite: Ca ₁₀ (PO ₄ ) ₆ F ₂
Carbonate apatite: CO ₃ Ap
Tricalcium phosphate: Ca ₃ (PO ₄ ) ₂
Tetracalcium phosphate: Ca ₄ O (PO ₄ ) ₂
Eighth calcium phosphate: Ca ₈ (PO ₄ ) ₆・ 5H ₂ O
Of these, hydroxyapatite and tricalcium phosphate are preferably used.
[0006]
These apatites are the main components (inorganic components) of teeth and bones, and are extremely safe materials excellent in biocompatibility. For this reason, hydroxyapatite, tricalcium phosphate, and the like are also used as biomaterials in artificial joints and artificial tooth roots. Hydroxyapatite is known to be substituted with various trace elements in the position of calcium ion, phosphate ion, hydroxide ion, and the one in which hydroxide ion is replaced with fluorine ion becomes fluoroapatite, When carbonate ions are taken into the crystal, it becomes carbonate apatite.
Synthetic products are generally used for the apatites, and such commercially available synthetic products can also be used in the present invention. These are not particularly limited, but are supplied in the form of a white aqueous suspension or powder, and the average particle diameter is 1 to 70 μm.
[0007]
The content of at least one selected from the group consisting of hydroxyapatite, fluoroapatite, carbonate apatite, tricalcium phosphate, quaternary calcium phosphate, and octacalcium phosphate in the oral composition of the present invention is the total mass of the oral composition. 0.1-50 mass% is suitable based on this, Preferably it is 1-30 mass%. If this amount is less than 0.1% by mass, the recalcification of the tooth surface and the effect of removing and removing plaque are not exhibited. There may not be.
[0008]
As the magnesium salt used in the present invention, at least one selected from magnesium pyrophosphate, dibasic magnesium phosphate, tribasic magnesium phosphate and the like can be used.
Magnesium salts are used for the purpose of suppressing the conversion of calcium hydrogen phosphate, which is blended in foods and dentifrices, to hydroxyapatite, and some are commercially available. In the present invention, these commercially available products can be used. Content with respect to the total mass of the composition for oral cavity of magnesium salt is 0.05-10 mass%, Preferably it is 0.1-5 mass%. If it is less than 0.05% by mass, the expected effect is not exhibited, and if it exceeds 10% by mass, an effect commensurate with the content cannot be obtained and the usability may be impaired.
[0009]
Zeolite used in the present invention is widely used in dentifrices, cosmetics, detergent builders, industrial catalysts, paper materials, paints, resins, etc., and is used in these in the present invention. Commercially available products can be used.
The zeolite used in the present invention may be a natural zeolite or a synthetic zeolite, and examples of the natural zeolite include dysmondane, wylakite, lomontite, yugawaranite, shabasite, gallonite, govinsite, mordenite, and anal sym.
Synthetic zeolites include zeolite A, zeolite X, zeolite Y, synthetic mordenite, ZSM-5, and ZSM-11. Further, metallosilicates in which a part of aluminum contained in these zeolites is replaced with other trivalent metals may be used, for example, ferricsilicate, titanosilicate, gallosilicate, zincosilicate, borosilicate and the like. Further, it may be a zeolite analog in which a part of silicon in the zeolite is replaced with other tetravalent atoms, such as aluminophosphate. Among these, zeolite A, mordenite, ZSM-5, and zincosilicate are preferable.
Content with respect to the total mass of the composition for oral cavity of the zeolite used for this invention is 0.1-20 mass%, Preferably it is 0.5-10 mass%. If it is less than 0.1% by mass, the expected effect is not exhibited. On the other hand, even if it exceeds 20% by mass, an effect commensurate with the content cannot be obtained and the usability may be impaired.
[0010]
The hydrous aluminum silicates used in the present invention are widely used in dentifrices, cosmetics, paints, pigments, adsorbents, dispersion stabilizers, etc., and are used in the present invention. Commercially available products can be used.
Examples of hydrous aluminum silicates used in the present invention include kaolinite, halloysite, pyrophyllite, sericite, montmorillonite, chlorite, illite, uranium unmo, bentonite, and laponite. Among these, montmorillonite and bentonite are included. Is preferred.
The content of the hydrous aluminum silicate used in the present invention with respect to the total mass of the oral composition is 0.1 to 20% by mass, preferably 0.5 to 10% by mass. If it is less than 0.1% by mass, the expected effect is not exhibited. On the other hand, even if it exceeds 20% by mass, an effect commensurate with the content cannot be obtained and the usability may be impaired.
[0011]
Depending on the type of the composition for oral cavity of the present invention, in addition to the above-mentioned components, the following components can be blended as necessary within the range of normal use amounts.
<Abrasive>
Silica-based abrasives such as silica gel, precipitated silica, pyrogenic silica, hydrous silicic acid, anhydrous silicic acid, dicalcium phosphate dihydrate, dibasic calcium phosphate anhydrate, calcium pyrophosphate, aluminum hydroxide, alumina, Examples include light calcium carbonate, heavy calcium carbonate, magnesium carbonate, and synthetic resin-based abrasive, and one or more of these can be used in combination. As for the compounding quantity of the said abrasive | polishing agent, 3-60 mass% is preferable with respect to the whole composition, More preferably, it is 10-45 mass%.
[0012]
<Wetting agent>
One kind or two or more kinds of polyhydric alcohols such as glycerin, concentrated glycerin, diglycerin, sorbitol, maltitol, dipropylene glycol, propylene glycol, 1,3-butylene glycol, polyethylene glycol, and xylitol can be used. .
<Binder>
Carrageenan (ι, λ, κ), alginic acid, sodium alginate, propylene glycol alginate, calcium-containing sodium alginate, potassium alginate, calcium alginate, ammonium alginate and its derivatives, polyvinylpyrrolidone, xanthan gum, guar gum, gelatin, agar , Sodium carboxymethyl cellulose, hydroxyethyl cellulose, sodium polyacrylate, and the like, and one or more of these can be used in combination.
[0013]
<Foaming agent>
Sodium lauryl sulfate, sodium lauroyl sarcosine, sodium alkylsulfosuccinate, sodium coconut oil fatty acid monoglycerol sulfonate, sodium α-olefin sulfonate, N-acyl amino acid salts such as N-acyl glutamate, 2-alkyl-N-carboxymethyl -N-hydroxyethyl imidazolinium betaine, maltitol fatty acid ester, sucrose fatty acid ester, polyglycerin fatty acid ester, fatty acid diethanolamide, polyoxyethylene sorbitan monostearate, polyoxyethylene hydrogenated castor oil, polyoxyethylene fatty acid ester, etc. Of these, one or more of these can be used in combination.
[0014]
<Sweetener>
Saccharin sodium, aspartame, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidyl dihydrochalcone, perilartine, etc.
<Preservative>
Parabens such as methylparaben, ethylparaben, propylparaben, butylparaben, sodium benzoate, phenoxyethanol, alkyldiaminoethylglycine hydrochloride and the like.
[0015]
<Perfume ingredients>
Use one or more of l-menthol, anethole, menthone, cineol, limonene, carvone, methyl salicylate, ethyl butyrate, eugenol, thymol, cinnamic aldehyde, trans-2-hexenal, etc. Can do. Although these components may be mix | blended with a single item, you may mix | blend the essential oil etc. which contain these.
In addition to the above fragrance components, fragrance components such as aliphatic alcohols and esters thereof, terpene hydrocarbons, phenol ethers, aldehydes, ketones, and lactones, and essential oils may be blended within a range that does not interfere with the effects of the present invention. The blending amount of the fragrance is preferably 0.02 to 2% by mass with respect to the entire composition.
[0016]
<Active ingredient>
Lysozyme chloride, monofluorophosphate, sodium fluoride, potassium fluoride, sodium monofluorophosphate, hinokitiol, ascorbic acid, chlorhexidine salts, triclosan, isopropylmethylphenol, cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, bisabolol, acetic acid 1 tocopherol, ε-aminocaproic acid, tranexamic acid, aluminum hydroxyl allantoin, aluminum lactate, dihydrocholesterol, glycyrrhetinic acid, glycyrrhizinate, copper chlorophyllin salt, sodium chloride, guaiazulene sulfonate, dextranase, pyridoxine hydrochloride, etc. Species or two or more can be blended.
<Others>
Blue 1 and other pigments, pigments such as titanium oxide, antioxidants such as dibutylhydroxytoluene, chelating agents such as edetate, cha extract, tea dry distillation liquid, propolis extract, and flavoring agents such as sodium glutamate.
[0017]
The composition for oral cavity of this invention can be manufactured according to a conventional method, and a manufacturing method is not specifically limited. The obtained composition such as toothpaste can be used by being filled in an aluminum tube, a laminate tube, a glass vapor deposition tube, a plastic tube, a plastic bottle, an aerosol container or the like.
[0018]
【The invention's effect】
The oral composition of the present invention exhibits excellent storage stability because it has been prevented from changes over time such as hardening, roughening, and liquid separation, which are conventionally found in oral compositions containing apatites. In addition, it has excellent palatability and usability.
[0019]
【Example】
EXAMPLES Hereinafter, although an experiment example and an Example demonstrate this invention in detail, this invention is not restrict | limited to the following Example. In addition,% shown in the following example means the mass%.
Various toothpastes were prepared according to conventional methods with the formulations shown in Tables 1 and 2 (unit: mass%).
<Stability test>
After filling the above toothpaste into an aluminum tube, it was stored at 50 ° C. for 2 months. These stored products were subjected to a sensory evaluation of the stability of the toothpaste based on the following evaluation criteria.
"Evaluation criteria"
Toothpaste stability: The ease of extrusion from the tube, the appearance of the contents, and the liquid separation from the toothpaste were sensorially evaluated by touch and visual observation.
◎ …… Very stable.
○ …… Almost stable.
Δ: Slightly poor stability.
X: Very poor stability.
[0020]
<Monitor test>
Based on the following evaluation criteria, sensory evaluation on the feeling of use of various toothpastes was performed by 10 monitors.
"Evaluation criteria"
1) Tooth brushing feeling: Evaluate whether or not teeth are brushed.
4 points ... I felt I was able to polish it.
3 points: I felt that I was able to improve.
2 points ... Slightly polished.
1 point .... I feel very polished.
[0021]
2) Rowing feeling: The feeling of rowing after the end of brushing is evaluated by sensation.
4 points ... I felt bald enough.
3 points: I felt almost bald.
2 points ... Slightly poor feeling of rowing.
1 point ... Very poor feeling of rowing.
3) Aftertaste: The aftertaste after brushing is evaluated by sensation.
4 points ... It is refreshing without bitterness.
3 points ... Almost no bitterness.
2 points ... Some bitterness remains.
1 point ... Bitter taste remains.
In addition, about evaluation, the average value of 10 persons was calculated | required and it performed in the following four steps.
4 <◎ ≦ 3
3 <○ ≦ 2
2 <△ ≦ 1
1 <× ≦ 0
The results are shown in Table 1 and Table 2 together.
[0022]
[Table 1]

[0023]
[Table 2]

[0024]
From the above experimental results, it can be seen that the toothpaste according to the present invention is excellent in stability over time, and in terms of palatability and usability. Moreover, when said experiment was done also about the toothpaste of Examples 9-24 shown below, the same result as the above was obtained. Hereafter, the composition of the toothpaste of Examples 9-24 is shown. The unit of the amount is mass%.
[0025]
[Example 9]

[0026]
[Example 10]

[0027]
Example 11

[0028]
Example 12

[0029]
Example 13

[0030]
Example 14

[0031]
Example 15

[0032]
Example 16

[0033]
[Example 17]

[0034]
Example 18

[0035]
Example 19

[0036]
Example 20

[0037]
Example 21

[0038]
[Example 22]

[0039]
Example 23

[0040]
Example 24

Claims (4)

An oral composition containing at least one selected from the group consisting of hydroxyapatite, fluoroapatite, carbonate apatite and tricalcium phosphate, the group comprising magnesium pyrophosphate, dibasic magnesium phosphate and tribasic magnesium phosphate At least one magnesium salt selected from 0.05 to 10% by mass based on the total mass of the oral composition, and at least one selected from the group consisting of zeolites and hydrous aluminum silicates is 0.1 The composition for oral cavity characterized by containing -20 mass% (except when it contains calcium hydrogen phosphate). Furthermore, the composition for oral cavity of Claim 1 containing a silicic anhydride and / or a hydrous silicic acid. Furthermore, the composition for oral cavity of Claim 1 or 2 containing at least 1 sort (s) chosen from monofluorophosphate, sodium fluoride, and potassium fluoride. It is a dentifrice, The composition for oral cavity of any one of Claims 1-3 .