JP4286480B2 - Disinfectant - Google Patents

Description

【００４６】
【表２】

【００４７】
そして、上記で得られた殺菌液の各９．９ｍＬを試験管に入れ、これに、カンジダ・アルビカンス（Candida albicans IFO 1594）を１０⁸〜１０⁹ｃｆｕ／ｍＬ含む菌液の０．１ｍＬを加えて攪拌し、最終的に１０⁶〜１０⁷ｃｆｕ／ｍＬの菌数を含む菌懸濁液を、それぞれ調製した。その後、それらを２３℃で、１時間、放置した後に、かかる菌懸濁液の１ｍＬを取り出し、ブドウ糖ペプトン寒天培地の２０ｍＬを用いて、平板希釈法によりサンプル１ｍＬ中の生菌数を測定した。そして、この生菌数から、処理液１ｍＬ中の生菌数を算出した後、下記の計算式に従って、対数に換算した菌減少数（log reduction）を求め、その結果を、下記表３に示した。
菌減少数＝ｌｏｇ（調製直後の菌懸濁液１ｍＬ中の生菌数）
−ｌｏｇ（処理後の菌懸濁液１ｍＬ中の生菌数）
【００４８】
また、上記菌減少数（log reduction）の値から、殺菌効力の評価を行ない、その結果を、下記表３に併せ示した。なお、かかる評価基準は、ＩＳＯ１４７２９におけるFirst Criteria（殺菌に関する）を満たす場合に○、満たさない場合に×、とした。
【００４９】
【表３】

【００５０】
かかる表３の結果からも明らかなように、塩化ナトリウムの濃度、及び、リン酸及びその塩の合計濃度が、それぞれ、０〜０．２重量％、０〜０．５重量％となるように、塩化ナトリウム、リン酸及びその塩が何等含有せしめられておらず、且つ、本発明に従って採用される所定の等張化剤が含有せしめられてなる、実験例１〜１３に係る殺菌液にあっては、短時間で、優れた殺菌効果が実現され得ている。
【００５１】
【発明の効果】
以上の説明から明らかなように、本発明に従う殺菌液にあっては、塩化ナトリウム濃度が零とされると共に、リン酸及びその塩の合計濃度が零乃至は可及的に小ならしめられ、且つ、所定の等張化剤が、塩化ナトリウムに代わる等張化剤として含有せしめられているため、殺菌剤の殺菌能力が極めて効果的に発現せしめられ得ることとなるのであり、以て、かかる殺菌剤成分の殺菌液中の濃度を低く抑えても、高い殺菌効果乃至は防腐効果を有利に得ることが出来、またこれによって、生体に対する安全性が、より一層、向上せしめられ得るのである。[0001]
[Prior art]
The present invention relates to a bactericidal solution, and more particularly to a bactericidal solution that exhibits an excellent bactericidal or antiseptic effect that can be advantageously used as an eye drop, a bactericidal solution for contact lenses, a preservative for cosmetics, and the like.
[0002]
[Background]
As is well-known, liquids for contact lenses include bacteria components in addition to detergent components for removing dirt and proteins derived from tears and eye oils attached to contact lenses. A bactericide component for preventing contamination by microorganisms such as fungi and the like is contained.
[0003]
Various compounds have been conventionally studied as a bactericide component to be added to such a contact lens bactericidal solution. In order to satisfy practical requirements from the viewpoint of bactericidal or antiseptic, However, it was necessary to increase the amount of use. However, if the concentration of the bactericidal agent is high, the toxicity becomes strong, or the bactericidal agent is adsorbed on the contact lens, particularly the soft contact lens, and easily accumulates on the surface of the contact lens. A problem arises in terms of safety because it may cause irritation and cause damage. Therefore, at present, the composition of the bactericide has been studied so that a higher bactericidal efficacy can be obtained with a smaller content.
[0004]
For example, in Japanese Patent Application Laid-Open No. 10-108899, polyhexamethylene biguanide, which is a biguanide fungicide, is used as glycerin, propylene glycol, etc. as a solution for contact lenses that exhibits an excellent bactericidal effect and has safety for eyes. And a non-ionic isotonic agent, and a contact lens having an excellent disinfecting effect and sufficient safety for the eyes is disclosed in JP-A-11-249087. It has been proposed to use polyquaterium together with nonionic tonicity agents and / or amino acids as a solution for use, and the adoption of these solutions makes it possible to improve the bactericidal efficacy of contact lens solutions. However, there is still room for improvement in terms of its characteristics. Than in it had been in the range.
[0005]
[Solution]
Here, the present invention has been made against the background of such circumstances, and the problem to be solved is to reduce the toxicity to the living body as much as possible to ensure sufficient safety and to be excellent. Another object of the present invention is to provide a sterilizing solution capable of realizing a sterilizing effect or antiseptic effect.
[0006]
[Solution]
And, as a result of intensive studies to solve such problems, the present inventors have found that the sterilization solution containing a bactericide contains a chloride that is generally contained in order to adjust its osmotic pressure. Bactericidal ability inherent to bactericidal agents, such as strong electrolytes such as sodium and inorganic salt buffers such as phosphoric acid and its salts used to adjust the pH of bactericidal solutions In addition, the sodium chloride concentration and the total concentration of phosphoric acid and its salt are made zero or as low as possible. It has been found that by using a relatively small predetermined isotonic agent, an extremely excellent bactericidal effect or antiseptic effect can be exhibited as compared with the conventional case.
[0007]
Therefore, the present invention has been completed based on such knowledge, and the gist thereof is that in a bactericidal solution containing polyhexamethylene biguanide , xylose, mannitol, glucose, xylitol, inositol, At least one isotonic agent selected from the group consisting of fructose, sucrose, trehalose, trimethylglycine, creatinine, tranexamic acid, nicotinamide, urea, triethanolamine, N, N-dimethylacetamide and ethylene carbonate It is characterized by being adjusted so that the sodium chloride concentration in the sterilizing solution is 0% by weight and the total concentration of phosphoric acid and its salt is 0-0.5% by weight. It is in the sterilizing solution.
[0008]
In short, in such a sterilizing solution according to the present invention, since the sodium chloride concentration and the total concentration of phosphoric acid and its salts are made as small as possible, the sterilizing ability of the bactericide is extremely high. Therefore, even if the concentration of the bactericide component in the bactericidal solution is kept low, a high bactericidal or antiseptic effect can be obtained advantageously, and As a result, the safety to the living body can be further improved.
[0009]
Moreover, in the present invention, a predetermined isotonic agent in which the electrical conductivity of a 0.1 mol / L aqueous solution is 500 mS / m or less is used in place of conventional sodium chloride as a tonicity agent. Thus, the osmotic pressure of the sterilizing solution can be adjusted without adversely affecting the sterilizing ability of the sterilizing agent, so that the sterilizing effect of the sterilizing solution can be advantageously expressed. .
[0010]
The excellent sterilization mechanism relating to the sterilizing solution according to the present invention is not yet fully clarified, but according to the inventor's guess, it is scattered on the surface of microorganisms such as bacteria. If the positive site of the bactericidal agent contained in the bactericidal solution sticks to the negative site, the bactericidal action can be realized. By dissolving the buffer such as electrolyte and phosphoric acid, the relatively small size of positive ions and negative ions enter between the microorganism and the disinfectant, reducing the electrical attractive force, The disinfecting ability of the disinfectant may be inhibited, or the structure of the disinfectant itself in the solution may be changed by the electrolyte, thereby inhibiting the disinfecting ability of the disinfectant. And shall be considered, in the present invention, by eliminating such an inhibitory action, it being assumed that disinfecting effect is brought advantageously improved.
[0011]
By the way, in the sterilizing solution according to the present invention, preferably, the isotonic agent desirably has an electric conductivity of 100 mS / m or less in its 0.1 mol / L aqueous solution. As a result, a further excellent bactericidal effect can be exhibited.
[0012]
Further, according to one of the preferred embodiments of the bactericidal solution according to the present invention, the tonicity agent is a nonionic tonicity agent comprising at least one of a predetermined sugar and a reducing sugar. preferably, Examples of the nonionic tonicity agent, Ma N'nitoru, glucose, xylitol, inositol, fructose, sucrose or trehalose, and be needed use.
[0013]
Furthermore, according to one further preferred embodiment of the disinfection solution according to the present invention, as the isotonic agent, trimethyl glycine, creatinine, tranexamic acid, nicotinic acid amide, urea, triethanolamine, N, N-dimethyl at least one compound selected from the group consisting of acetamide and ethylene carbonate, and be needed use.
[0014]
Furthermore, according to this onset bright, as germicides, polyhexamethylene biguanide (PHMB) is used, the fungicide such as this, germicidal efficacy or sterilizing solution may be very highly exhibit antiseptic effect It will be.
[0015]
In addition, according to another preferred embodiment of the bactericidal solution according to the present invention, the isotonic agent has an osmotic pressure of 50 mOsm / kg or more in its 0.1 mol / L aqueous solution. Desirably, this makes it possible to keep the amount of isotonic agent added low.
[0016]
In addition, the sterilizing solution according to the present invention desirably has an osmotic pressure of 250 mOsm / kg or more, which can advantageously avoid problems such as irritation to the eyes and skin.
[0017]
Furthermore, according to one of the other desirable embodiments of the sterilizing liquid according to the present invention, the sterilizing agent is preferably contained in a ratio of 0.00001 to 0.1% by weight, and such a configuration is adopted. By doing so, the safety of the sterilizing solution can be ensured to a very high degree .
[0018]
Further, the gist of the present invention is a contact lens sterilization solution, particularly a soft contact lens sterilization solution, which is composed of the sterilization solution as described above. In such a contact lens sterilization solution or soft contact lens sterilization solution according to the present invention, the concentration of the bactericide added to the solution can be kept low in order to exert the intended sterilization effect. Therefore, even if the sterilization (disinfection) treatment by immersion of the contact lens or the soft contact lens is performed for a long time, the adsorption of the sterilizing agent on the surface of the contact lens or the soft contact lens is practically ignored. Therefore, the disinfectant adsorbed on the surface of the lens can be safely and effectively sterilized (disinfected) without causing any damage such as inflammation to the eye. Is possible. In particular, when used as a sterilizing solution for soft contact lenses, such a liquid agent has an advantage that it can be advantageously avoided that the soft contact lens swells. is there.
[0019]
DETAILED DESCRIPTION OF THE INVENTION
By the way, the sterilizing liquid according to the present invention mainly contains water, and contains a predetermined isotonic agent together with the sterilizing agent, and further contains a sodium chloride content that inhibits the sterilizing ability of the sterilizing agent, By making the total content of phosphoric acid and its salt zero or as small as possible, the bactericidal effect is exhibited extremely effectively, and there are exceptionally distinctive features. It has.
[0020]
Thus, in the present invention, in order to express the bactericidal or antiseptic effect of a bactericidal solution containing a bactericide extremely effectively, it has been generally used as a tonicity agent. it is not to want to make strong electrolyte such as sodium chloride and potassium chloride are prevented allowed containing all.
[0021]
However, and as thus, when the sodium chloride concentration is made to 0 by weight%, from where the osmotic pressure of the sterilizing liquid is too low, in the present invention, instead of such sodium chloride, 0 .1mol / L the electrical conductivity of the aqueous solution 500 mS / m or less, preferably, 300 mS / m or less, more preferably, so that the use of certain isotonic agent or less 100 mS / m. However, when the electrical conductivity of the isotonizing agent in the 0.1 mol / L aqueous solution exceeds 500 mS / m, the disinfecting ability of the disinfectant is inhibited and sufficient disinfecting effect cannot be realized. This is because the desired bactericidal effect cannot be obtained.
[0022]
As the tonicity agent used in the present invention such as to above, meet the above requirements, and high safety even so, for example, Ya nonionic tonicity agents predetermined sugars and reducing sugars , trimethyl glycine, creatinine, tranexamic acid, nicotinic acid amide, urea, triethanolamine, N, N- dimethylacetamide and ethylene carbonate can be cited, among them, at least one or more compounds are suitably It will be selected and used. Incidentally, such an isotonic agent has a feature of reducing a change in the lens size during the immersion treatment of the contact lens or causing no problem such as swelling.
[0023]
Here, as the nonionic tonicity agent for the sugar and reducing sugar, D-arabinose, L-arabinose, D-xylulose, L-xylulose, D-xylose, 2-deoxy-β-D-ribose, D -Lyxose, L-lyxose, D-ribulose, D-ribose, D-arabitol, ribitol, D-xylitol, D-altrose, D-allulose, D-allose, D-idose, D-galactose, L-galactose, D-quinobose, D-glucose, D-gulose, D-digitose, D-digitoxose, L-sorbose, D-tagatose, D-fucose, D-fructose, D-mannose, D-inositol, galactitol , D -mannitol Monosaccharides such as agarobiose, isomaltose, xylobiose, and gen Obiosu, kojibiose, sucrose, cellobiose, alpha, alpha-trehalose, maltose, lacto - scan, it can be exemplified oligosaccharides such as rutinose, among them, Ma N'nitoru, glucose, xylitol, inositol, fructose, sucrose or trehalose Is preferred.
[0024]
And, as described above, these isotonic agents are inorganic salts of strong electrolytes that have been conventionally used to adjust the osmotic pressure of the bactericidal solution, specifically, as an alternative to sodium chloride, potassium chloride, etc. In view of physiological osmotic pressure so as not to cause irritation to eyes or skin when using the bactericidal solution according to the present invention, it is usually about 250 to 400 mOsm. It is added and contained so as to be within a range equal to the physiological osmotic pressure, and is generally 0.5 to 7.0% by weight (w / w%), preferably 1.0 to 5.0% by weight (w / W%) in the sterilizing solution. In addition, when there is too little content of these tonicity agents, the osmotic pressure of a sterilization liquid will become low, and when too large, the problem of raising the osmotic pressure of the same liquid remarkably will be caused.
[0025]
In addition, in such an isotonic agent, in order to prevent the addition amount from becoming excessive, the penetration is usually 50 mOsm / kg or more, more preferably 80 mOsm / kg or more in the 0.1 mol / L aqueous solution. What has a pressure will be used especially suitably. However, if the osmotic pressure is too small, the amount of tonicity agent added to achieve the desired osmotic pressure increases, and therefore the bactericidal action of the bactericide tends to be disturbed. In addition, there is a risk that the bactericidal effect may be reduced, and there is a problem of solubility that the tonicity agent precipitates or cannot be dissolved, a cost increase, and a property change of the liquid such that the viscosity becomes high and the touch becomes poor. This is because there is a risk of being provoked.
[0026]
By the way, as the bactericidal agent used in the present invention, those having excellent bactericidal power, compatibility with contact lenses, eyes, and skin, and those that are difficult to cause allergies and other disorders, have been conventionally known. Among them , in particular, polyhexamethylene biguanide (PHMB) may be mentioned.
[0027]
The fungicides as described above are usually used in the range of about 0.00001 to 0.1% by weight (w / w%), preferably about 0.00001 to 0.01% by weight. An effective sterilizing effect or antiseptic effect is exhibited. When the content of such a bactericidal agent is too small, a sufficient bactericidal effect or antiseptic effect cannot be obtained. When the content exceeds 0.1% by weight, toxicity is increased. Thus, for example, there may be a problem in terms of safety, such as having an adverse effect on eyes and skin, and promoting the adsorption of a bactericide on the contact lens surface.
[0028]
In short, in the bactericidal solution according to the present invention, at least one or more predetermined tonicity agents excellent in safety are used as the tonicity agent instead of sodium chloride exhibiting high ion conductivity. from where you are, bactericidal activity of polyhexamethylene Biguani soil, it has become the leg sweep member can be extremely effectively expressed.
[0029]
By the way, in the bactericidal solution according to the present invention, depending on the use, etc., further, for pH drops, buffering agents, surfactants, chelating agents, thickeners, etc. Various known additives that are added to and contained in ophthalmic liquids such as bactericidal liquids and liquids such as cosmetics may be appropriately selected and contained.
[0030]
For example, when such a bactericidal solution according to the present invention is used as an ophthalmic solution such as an eye drop or a contact lens bactericidal solution or as a cosmetic, it may irritate or cause damage to the eyes and skin. The pH value is preferably adjusted to 5.0 to 8.0, particularly around 7.0. In order to advantageously realize such a pH range, sodium hydroxide or hydroxide A pH adjuster such as potassium or hydrochloric acid can be added. However, also a pH adjusting agent described above, similarly to the sodium chloride, from where a strong electrolyte, it is Ru must suppress the amount as low as possible.
[0031]
In addition, in order to effectively maintain the pH of the sterilizing solution in the above-described range and in a safe range for the eyes and skin, a buffering agent may be added in addition to the pH adjusting agent. As the buffering agent, it is appropriately selected and used from various conventionally known ones. Specifically, citrate buffer, phosphate buffer, borate buffer, carbonate buffer, tris (hydroxymethyl) aminomethane (TRIS) buffer, and Good-Buffer such as Bis-Tris In particular, it can be exemplified because it is safe for the eyes and can reduce the influence on the contact lens. The amount of the buffer added is generally about 0.01 to 2% by weight (w / w%), but the buffer exhibits a relatively large ionic conductivity when dissolved in water. For example, when using citric acid, phosphoric acid, or a salt thereof, the amount of addition should be reduced to zero because there is a possibility that the disinfecting ability of the disinfectant may be inhibited by the buffer. Need to be as low as possible.
[0032]
Specifically, when adjusting the pH using a phosphate buffer, in the case of a citrate buffer, the total concentration of phosphoric acid and its salt is 0-0.5 wt%. It is necessary to add so that the total concentration of citric acid and its salt is 0 to 0.1% by weight. When the concentration of such a buffering agent exceeds the above range, strong electrolytes such as sodium chloride Even if the addition amount is kept low, the action of the bactericidal agent is inhibited by the buffering agent, so that the intended bactericidal ability cannot be fully expressed.
[0033]
Furthermore, a surfactant as a cleaning agent may be added to the bactericidal solution according to the present invention in order to advantageously exhibit the effect of removing dirt such as eye grease (cleaning effect). Any agent known in the art can be used as long as it is highly safe to the living body and does not affect the contact lens material, etc., and at a concentration that does not impair the function and effect of the present invention. Are preferably added and contained.
[0034]
Specific examples of such surfactants include, for example, polyglycerin fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene / polyoxypropylene block copolymer, polyoxyethylene / polyoxypropylene ethylenediamine, and polyoxyethylene sorbitan. Fatty acid ester, polyoxyethylene alkyl phenyl ether formaldehyde condensate, polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl phenyl ether, polyoxyethylene glycerin fatty acid ester, polyoxyethylene sorbite fatty acid ester, polyoxyethylene castor oil, polyoxyethylene Sterol, polyoxyethylene hydrogenated sterol, polyoxyethylene fatty acid ester, polyoxyethylene poly Carboxymethyl propylene alkyl ethers, polyoxyethylene lanolin alcohol, polyoxyethylene alkyl amine, polyoxyethylene alkyl amide, polyoxyethylene alkyl ether phosphoric acid, can be mentioned polysorbate.
[0035]
The amount of the surfactant added is generally about 0.001 to 5% by weight (w / w%), preferably about 0.005 to 2% by weight when used as an ophthalmic solution. Therefore, it is more preferably about 0.01 to 1% by weight. However, if the amount added is too small, the resulting cleaning effect will be insufficient, and if it is too large, the cleaning effect will not change and may cause eye irritation. It is.
[0036]
Further, the sterilizing solution according to the present invention may further contain a thickener, if necessary, for example, various gums such as heteropolysaccharides, synthetic organic polymer compounds such as polyvinyl alcohol, poly-N- Thickeners such as vinyl pyrrolidone, polyethylene glycol, polypropylene glycol, polyacrylamide and the like, and further cellulose derivatives and starch derivatives can be appropriately used.
[0037]
Further, as other additive components, chelating agents and the like can be mentioned, but such additive components are safe for living bodies and do not adversely affect the material of contact lenses. For example, any conventionally known one can be used, and they can be contained in the sterilizing solution according to the present invention as necessary.
[0038]
In particular, when the sterilizing liquid according to the present invention is used as a sterilizing liquid for contact lenses, a metal chelating agent is used in order to prevent metal ions such as calcium in tears from adsorbing to contact lenses, particularly soft contact lenses. Such metal chelating agents include, for example, ethylenediaminetetraacetic acid (EDTA) and salts thereof, such as ethylenediaminetetraacetic acid · disodium (EDTA · 2Na), ethylenediaminetetraacetic acid · trisodium (EDTA · 3Na) and the like. In addition, the addition amount of such a metal chelating agent will be contained in the bactericidal solution within a quantitative range that does not inhibit the action / effect of the present invention, and is generally 0.01 to 1.0% by weight ( w / w%).
[0039]
By the way, in preparing the sterilizing solution according to the present invention containing the predetermined sterilizing agent or tonicity agent as described above, no special method is required, and it is the same as the case of preparing a normal aqueous solution. Furthermore, it can be easily obtained by dissolving each component in an aqueous medium such as purified water or distilled water.
[0040]
The sterilizing solution according to the present invention obtained as described above is added to, for example, a contact lens sterilizing solution, especially a soft contact lens sterilizing solution, an ophthalmic solution such as eye drops, and cosmetics. As a preservative to be used, it will be suitably used.
[0041]
For example, when cleaning the contact lens using the sterilizing solution according to the present invention as the contact lens sterilizing solution, first, the contact lens removed from the eyes is filled in a suitable container filled with the contact lens sterilizing solution according to the present invention. In addition, disinfection is performed by dipping for a predetermined time. When the contact lens is to be worn again, the contact lens is taken out from the solution, washed, and then worn. In such wearing, the disinfected contact lens is rinsed with physiological saline or the like. Furthermore, since the sterilizing solution is safe for the eyes, the contact lens immersed in the sterilizing solution can be taken out and directly applied to the eye. . Still further, the disinfection of the contact lens using the sterilizing solution may be performed after the contact lens is cleaned.
[0042]
In addition, as a contact lens which is the target of such a sterilizing solution for contact lenses, the type thereof is not limited at all, for example, soft contact lenses classified into all of non-water content, low water content, high water content, and the like, and The hard contact lens can be the object, and the material of the contact lens is not questioned when the contact lens bactericidal solution according to the present invention is applied. Among them, the contact lens bactericidal solution according to the present invention can be applied particularly advantageously to a soft contact lens in which the lens is not swollen.
[0043]
【Example】
Hereinafter, some experimental examples including examples of the present invention will be shown to clarify the present invention more specifically. However, the present invention is not limited by the description of such experimental examples. It goes without saying that it is not something that you receive. In addition to the following examples, the present invention includes various changes, modifications, and modifications based on the knowledge of those skilled in the art without departing from the spirit of the present invention, in addition to the above specific description. It should be understood that improvements and the like can be added.
[0044]
First, an osmotic pressure is set to about 290 mOsm / kg by adding a bactericide, an isotonic agent, and a chelating agent to a predetermined amount of distilled water at various ratios shown in Table 1 below. It was to prepare a germicidal solution according to the experimental example 1 and 1 3. As the fungicides, in sterilizing solution according to Experimental Example 1 and 1 3, I had use polyhexamethylene biguanide a (PHMB). In addition, as an isotonic agent, a 0.1 mol / L aqueous solution having electrical conductivity and osmotic pressure as shown in Table 2 below was used. As the chelating agent, ethylenediaminetetraacetic acid · disodium (EDTA · 2Na) was used.
[0045]
[Table 1]

[0046]
[Table 2]

[0047]
Then, each 9.9 mL of the bactericidal solution obtained above is put in a test tube, and 0.1 mL of a bacterial solution containing 10 ⁸ to 10 ⁹ cfu / mL of Candida albicans IFO 1594 is added thereto. Stirring was finally performed, and bacterial suspensions each finally containing 10 ⁶ to 10 ⁷ cfu / mL were prepared. Thereafter, they at 23 ° C., for 1 hour, after standing, removed 1mL of such cell suspension, using 20mL of Glucose Peptone agar medium, the number of viable bacteria in the sample 1mL was determined by plate dilution method . Then, after calculating the viable cell count in 1 mL of the treatment liquid from this viable cell count, the log reduction converted to logarithm was calculated according to the following formula, and the result is shown in Table 3 below. It was.
Number of bacteria reduced = log (number of viable bacteria in 1 mL of bacterial suspension immediately after preparation)
-Log (number of viable bacteria in 1 mL of bacterial suspension after treatment)
[0048]
Moreover, bactericidal efficacy was evaluated from the value of the above-mentioned log reduction, and the results are also shown in Table 3 below. In addition, this evaluation criteria was set to (circle) when satisfying First Criteria (related to sterilization) in ISO14729, and (x) when not satisfying.
[0049]
[Table 3]

[0050]
As is apparent from the results in Table 3, the sodium chloride concentration and the total concentration of phosphoric acid and its salt are 0 to 0.2% by weight and 0 to 0.5% by weight, respectively. , sodium chloride, phosphoric acid and its salts are not being allowed to contain any way, and, given isotonic agents employed in accordance with the present invention are thus the additional inclusion, the sterilization solution according to experimental example 1-1 3 In that case, an excellent sterilizing effect can be realized in a short time.
[0051]
【The invention's effect】
As apparent from the above description, in the sterilizing solution according to the present invention, the sodium chloride concentration is zero, or the total concentration of phosphoric acid and its salts zero crimped if small as possible And, since the predetermined tonicity agent is contained as an isotonic agent instead of sodium chloride, the bactericidal ability of the bactericide can be expressed very effectively, Even if the concentration of the bactericidal component in the bactericidal solution is kept low, a high bactericidal effect or antiseptic effect can be obtained advantageously, and the safety to the living body can be further improved thereby. .

Claims (6)

In a bactericidal solution containing polyhexamethylene biguanide , xylose, mannitol, glucose, xylitol, inositol, fructose, sucrose, trehalose, trimethylglycine, creatinine, tranexamic acid, nicotinamide, urea, triethanolamine, N, At least one tonicity agent selected from the group consisting of N-dimethylacetamide and ethylene carbonate is added, and the sodium chloride concentration in the sterilizing solution is 0% by weight , and phosphoric acid and its A bactericidal solution characterized in that the total concentration of the salt is adjusted to 0 to 0.5% by weight.   The sterilizing solution according to claim 1, wherein the tonicity agent has an electric conductivity of 100 mS / m or less in its 0.1 mol / L aqueous solution. The sterilizing liquid according to claim 1 or 2 , which has an osmotic pressure of 250 mOsm / kg or more. The sterilizing solution according to any one of claims 1 to 3 , wherein the polyhexamethylene biguanide is contained in a proportion of 0.00001 to 0.1% by weight. A sterilizing solution for contact lenses comprising the sterilizing solution according to any one of claims 1 to 4 . A sterilizing solution for soft contact lenses comprising the sterilizing solution according to any one of claims 1 to 4 .