JP4290604B2 - Multi-chamber container pinhole detector - Google Patents

Description

  The present invention relates to a detection device for detecting a pinhole in a partition wall of a flexible non-conductive resin-made multi-chamber container in which a partition wall that can communicate between the chambers is disposed and a conductive liquid is accommodated in each chamber. A multi-chamber container is a multi-chamber container in which a conductive fluid is accommodated in each of a plurality of chambers made of an electrically insulating flexible sheet, and a partition wall is disposed between adjacent chambers. Between the two chambers containing the infusion component and a partition wall that can be communicated by pressing between the two chambers by hand, and the present invention is provided between the chambers of such a multi-chamber container. The present invention relates to a pinhole detection device capable of reliably and quickly detecting the presence of a sealing failure in a partition wall that can be arranged, that is, the presence of a pinhole.

  Various multi-chamber containers have been developed that can separate and seal multiple substances and mix them immediately before use. In particular, in the field of pharmaceuticals, there is a great demand for a technology capable of filling a multi-chamber container with a plurality of drugs that cause a change over time such as coloring or deterioration due to interaction and mixing them immediately before use. For example, an infusion bag in which a partition wall that can be communicated by manually pressing between two chambers containing an infusion component for infusion and between both chambers is well known. In such an infusion bag, components such as glucose and amino acid that cause aging and deterioration due to interaction are stored separately in each chamber, and the infusion bag is pressed by hand immediately before administration to a patient. The septum is communicated to mix the infusion components in the two chambers.

  Since the partition wall of the infusion bag needs to be easily communicated by hand during use, it cannot be firmly welded during manufacture, and it is difficult to avoid poor sealing and pinholes. On the other hand, the bulkhead of the infusion bag has the ability to securely seal between the chambers of the infusion bag so that the infusion solution does not change over time or deteriorate until it is communicated for use after the infusion bag is manufactured. It is necessary. Therefore, it is an important issue to reliably and rapidly detect the sealing failure and the presence of pinholes in the partition wall of the infusion bag after manufacture.

Patent Document 1 (Japanese Patent Application Laid-Open No. 5-10913) discloses a sealing failure inspection apparatus between independent chambers of a multi-chamber container. This device includes a first electrode and a second electrode disposed close to two independent chambers of a multi-chamber container, an AC power source connected to the first electrode, and a space between the first electrode and the second electrode. Current measuring means for measuring the alternating current. When there is no sealing failure at the boundary between the two independent rooms, the measured current value is small, and when there is a sealing failure, the measured current value is increased, so that the sealing failure can be detected. In addition, since it is difficult to detect a sealing failure of 50 μm or less in the above method, the sealing failure of 50 μm or less is based on the difference in light intensity generated at the boundary between two independent chambers instead of current measurement. Can be detected.
However, in the current measuring means for measuring current using an AC power source, a dark current is large in principle, a sufficient S / N ratio cannot be obtained, and detection of a pinhole of 50 μm or less is extremely difficult. The light intensity measuring means for detecting the spark light must be used in combination. For this reason, two techniques are required, which is not preferable because it is a complicated and expensive device.
JP-A-5-10913 Japanese Patent Laid-Open No. 3-189531

  Patent Document 2 (Japanese Patent Application Laid-Open No. 3-189531) discloses an isolation means for a container containing a liquid material comprising a container isolated into a plurality of chambers by an isolation means and a liquid material isolated and enclosed in the plurality of chambers. A method for detecting a pinhole that has occurred is disclosed. In this method, a voltage or an electric current is applied to a liquid material sealed in one chamber via a container wall of the one chamber, and an electrical change generated in the liquid material of the other chamber is caused to occur in the container of the other chamber. Pinholes generated between both chambers are detected by measuring through the wall. In the invention of Patent Document 2, a non-conductive plastic plate is brought into contact with an object to be inspected, and a capacitor is not formed between the plastic plate and the liquid in the room, and a sufficient effect is obtained. Absent.

  The present invention detects a pinhole in a partition wall of a flexible multi-chamber container made of a flexible non-conductive resin in which a partition wall that can communicate between two adjacent chambers is disposed and a conductive fluid is accommodated in each chamber. In the detection device, the detection accuracy is improved, and even when the diameter (opening width) of the pinhole is smaller than 50 μm, it is possible to detect accurately and at high speed. Another object of the present invention is to provide an optimal shape structure arrangement of the electrodes in order to improve the accuracy of the detection device. Another object of the present invention is to provide an optimum structure of the transport facility in order to improve the detection speed of the detection device. Other objects and advantages of the present invention will be clarified in the following description.

The flexible non-conductive resin multi-chamber container to be inspected by the pinhole detection device of the present invention includes at least two chambers for storing the conductive fluid and a partition wall disposed between the adjacent chambers, The partition wall is opened by applying pressure from the outside before use, and the adjacent chambers communicate with each other. According to a first aspect of the present invention, the detection device includes an electrode having a contact surface made of at least two conductive materials, and at least one DC power source and ammeter connected to each electrode. After each contact with the outer wall, a pinhole in the partition wall is detected based on a current value detected by an ammeter when a voltage is instantaneously applied from the DC power source to the outer wall of each chamber.

According to a second aspect of the present invention, the detection device includes an electrode having a contact surface made of at least two conductive materials, and at least one DC power source and an ammeter connected to each electrode. Is capable of being placed in contact with the outer wall of each chamber, applying a voltage from the DC power source to each electrode, moving each electrode or the outer wall of each chamber, and instantaneously contacting them with an ammeter A pinhole in the partition is detected based on the detected current value. In the present invention, a fluid means a fluid that moves in a flexible and non-conducting resin multi-chamber container that does not solidify, and is used for medical infusion, various medical and household fluids. Includes animals. In the present invention, the fluid further contains low-viscosity substances such as water, fruit juice, milk, soy sauce, sauce, mirin, vinegar, oil and dialysate, and semi-solid substances such as miso and grated wasabi. Pouches with very high viscosity, sticky, mayonnaise, ketchup, roux, cream, roux miso, yogurt, oral nutrition, enteral nutrition, liquid detergents and creamy cosmetics Includes functional foods such as product contents, sports drinks and liquid supplements, curry, soup, miso soup, liquid foods, and other retort foods containing liquids as a medium.

The detection device of the present invention can include the following features. (1) The instant is within 1 millisecond. (2) The contact surface of each electrode with the outer wall of each chamber is 10 cm ² or more. (3) The DC power supply supplies a high voltage of 3000 volts or more. (4) Each chamber of the multi-chamber container contains an infusion component, and the partition wall communicates by pressing the adjacent chambers from the outside so that the infusion components in the adjacent chambers can be mixed. (5) Each said electrode is arrange | positioned in the conveyance path of the conveyance facility which conveys the said multi-chamber container. (6) The electrodes are raised when the chambers of the multi-chamber container transported by the transport facility are positioned above the electrodes, and the electrodes are instantaneously brought into contact with the outer walls of the chambers.

  FIG. 1 is a layout diagram illustrating the principle of detecting pinholes (adhesion failure) in the partition wall 32 that can communicate between the first chamber 12 and the second chamber 22 of the infusion bag 10 using the detection device 40 of the present invention. Yes, the infusion bag 10 is shown by a schematic cross-sectional view. FIG. 2 is a schematic plan view of the infusion bag 10. As shown in FIGS. 1 and 2, the infusion bag 10 includes a first chamber 12 that stores the chemical solution M1, a second chamber 22 that stores the chemical solution M2, and a partition wall 32 that is disposed between both chambers. A port portion 18 for sending the drug solution from the inside of the infusion bag to the outside and a hole 26 for suspension are provided. The chemical liquid M1 and the chemical liquid M2 are conductive, and the first chamber, the second chamber, the partition wall 32, and the like are made of a flexible nonconductive resin.

  As shown in FIGS. 1 and 2, the first chamber 12 and the second chamber 22 are formed by firmly bonding the peripheral portions 14, 16, and 24 of the flexible non-conductive resin film 20 stacked on each other. The bag-shaped space to be formed is formed by partitioning with a partition wall 32. The partition wall 32 is formed by adhering the upper and lower surfaces of the resin film 20 so that they can communicate (peel) by a method such as heating and melting. The partition wall 32 is opened by pressing the chemical solution in the first chamber or the second chamber from the outside, whereby the first chamber and the second chamber of the infusion bag 10 are communicated, and the chemical solutions M1 and M2 are mixed. Since the partition wall 32 is bonded with a weak adhesive force so as to communicate with each other, the partition wall 32 often includes an adhesion failure, that is, a pinhole, that allows the first chamber 12 and the second chamber 22 to communicate with each other.

  In FIG. 1, a detection device 40 that detects a pinhole includes a first electrode 42 having a metal surface (contact surface of a conductive material) disposed in contact with an outer wall 44 of the first chamber 12, and an outer wall of the second chamber 22. 54 includes a second electrode 52 having a metal surface disposed in contact with 54, an ammeter 62 connected between the first electrode 42 and the second electrode 52, and a DC power supply 64. The metal surface of the first electrode 42 is in contact with the outer wall 44 of the first chamber, the metal surface of the second electrode 52 is in contact with the outer wall 54 of the second chamber, and a voltage is applied to both electrodes from the DC power supply 64. Occasionally, a sealing failure in the partition wall 32, that is, a pinhole, is detected based on the current value detected by the ammeter 62.

To apply the voltage, after the chemical bag is conveyed, the first electrode 42 is brought into contact with the outer wall 44 of the first chamber and the metal surface of the second electrode 52 is brought into contact with the outer wall 54 of the second chamber. Thus, the DC power source 64 passes through the ammeter 62 and the metal surface of the first electrode 42 to the outer side 44 of the first chamber, and the DC power source 64 passes through the metal surface of the second electrode 52 to the outer wall 54 of the second chamber. It can be done simultaneously and instantaneously. Further, the chemical solution bag is instantaneously moved onto the first electrode 42 and the second electrode 52 which are connected to the DC power source 64 and applied with a voltage, or each electrode is moved instantaneously to move the outer 44 of the first chamber. The metal surface of the first electrode 42 and the outer wall 54 of the second chamber can be simultaneously and instantaneously brought into contact with the metal surface of the second electrode 52. In the detection device 40 of FIG. 1, the metal surface of the first electrode 42 and the metal surface of the second electrode 52 are both 10 cm ² or more, and the DC power supply 64 supplies a high voltage of 3000 volts or more. The current value detected by the ammeter 62 is a current for charging the electric capacity formed by the multi-chamber container, that is, the infusion bag 10 between the first electrode 42, the second electrode 52, and both electrodes. For example, assuming that the electrode area S = 10 cm ² , the outer wall thickness d of the chemical solution bag = 300 μm, the dielectric constant ε ₀ = 2.3 of the outer wall, and the dielectric constant ε = 8.85 × 10 ^{−12 of} the vacuum, The capacitance C between the chemicals is C = ε ₀ ε (S / d) = 670 pF. The charging current when a DC voltage is applied to the capacitance is maximum at time t = 0 and decreases with the passage of time.

  Examples of the drugs M1 and M2 contained in the infusion bag shown in FIGS. 1 and 2 are obtained by adding an amino acid solution to a sugar / electrolyte solution for high-calorie infusion that can be used as a starting solution or maintenance solution for transcentral parenteral nutrition therapy. Infusion formulation. In this case, the amino acid solution is accommodated in the first chamber 12, the sugar and the electrolyte solution are accommodated in the second chamber 22, and during the administration, the first chamber or the second chamber is pressed from the outside to separate the separating means, thereby separating the liquid in both chambers. Mix. In the case of three or more types of infusions, fat emulsions and vitamins are in a preferred infusion formulation by being accommodated in three or more drug storage chambers other than the first chamber or the second chamber. If it is a thing, it will not be limited to this.

  The thermoplastic resin forming the infusion bag 10 is, for example, polyolefin such as polyethylene, polypropylene, ethylene-α-olefin copolymer, polyester such as polystyrene, polycarbonate, polyethylene terephthalate or polybutylene terephthalate, polyacetal, polyamide, polyphenylene ether, poly Examples thereof include ether sulfone, polysulfone, ethylene-vinyl acetate copolymer, polyvinyl chloride, polyvinylidene chloride, polyphenylene sulfide, fluororesin, acrylic resin, and cyclic polyolefin. Among these, polyethylene, polypropylene, ethylene-α-olefin copolymer, and polyethylene terephthalate are preferable. The port member 18 includes a rubber stopper (not shown) through which a hollow needle can be inserted, and is configured to be able to inject a chemical solution into the first chamber 12 or extract a chemical solution from the first chamber 12. The cylindrical portion of the port member 18 can be formed of a propylene / α-olefin random copolymer having a VICAT softening point of 121 ° C. or higher.

  FIG. 3 is a schematic plan view of the conveyor facility 80 in which the first electrode and the second electrode of the detection apparatus of the present invention are incorporated, and FIG. 4 is a schematic side view of the conveyor facility 80 of FIG. The conveyor facility 80 includes four first conveyor belts 72, 74, 76, 78, a first drive shaft 70 having drive surfaces 71, 73, 75, 77 that engage with each first belt, and each first belt. Engaging driven pulleys 71 ', 73', 75 ', 77' are included. The conveyor facility 80 is further engaged with three second conveyor belts 92, 94, 96, a second drive shaft 90 having drive surfaces 91, 93, 95 that engage with each second belt, and each second belt. Including driven pulleys 91 ′, 93 ′, 95 ′.

  The infusion bag 10 is normally conveyed from the first conveyor belts 72, 74, 76, 78 to the second conveyor belts 92, 94, 96, and when inspection shows that the partition wall is poorly sealed or pinholes are present, 4, the driven pulley side of the second conveyor belts 92, 94, 96 is raised by the air cylinder 101 and removed from the conveyance path. Holding bases 98 and 99 are arranged in parallel to the three second conveyor belts 92, 94 and 96, and support the infusion bag 10 to be conveyed.

  As shown in FIG. 3, the first to third upper surfaces 82, 83, and 84 of the conveyor facility 80 are disposed between the first conveyor belts 72, 74, 76, and 78, and are moved up and down in synchronization with the movement of the infusion bag 10. Is done. The metal surface 42 ′ of the first electrode 42 and the metal surface 52 ′ of the second electrode 52 are attached to the first upper surface 82 and the second upper surface 84, respectively. The second upper surface 83 supports the central portion of the infusion bag 10 when the electrode is not disposed and rises. As will be described later, when the infusion bag 10 is moved onto the first to third upper surfaces 82, 83, 84, these upper surfaces are raised.

  The conveyor facility 80 includes a crankshaft 87, a connecting rod 86, elevating guides 89 and 89 ', etc., for elevating the first to third upper surfaces. The rotational movement of the crankshaft 87 is controlled by control means (not shown) so that the raising / lowering operation of the first to third upper surfaces 82-84 is synchronized with the position of the infusion bag 10. The rotational speed of the crankshaft 87 is, for example, 33 revolutions per minute. The metal surface 42 'of the first electrode disposed on the first upper surface 82 and the metal surface 52' of the second electrode disposed on the third upper surface 84 are raised in synchronization with the movement of the infusion bag 10, and are shown in FIG. As shown, each of the infusion bags 10 contacts the outer wall 44 of the first chamber 12 and the outer wall 54 of the second chamber 22 simultaneously and instantaneously.

  When the metal surface 42 ′ of the first electrode contacts the outer wall 44 of the first chamber 12 of the infusion bag 10 and at the same time the metal surface 52 ′ of the second electrode contacts the outer wall 54 of the second chamber 22 of the infusion bag 10, the outer wall 44 An electric capacity C1 is formed by the metal surface 42 'and the first chemical liquid M1 that sandwich the outer wall 45, and an electric capacity C2 is formed by the metal surface 52' and the second chemical liquid M2 that sandwich the outer wall 45. When there is no pinhole due to adhesion failure or the like in the partition wall 32, there is an electric capacity C3 due to the first chemical solution M1 and the second chemical solution M2 sandwiching the partition wall 32. The electric capacity C3 has a relatively small value because the partition wall 32 has a certain width and the first chemical liquid M1 and the second chemical liquid M2 are relatively separated from each other. This state is shown in the equivalent circuit of FIG. 5, where the combined capacitance formed by C1, C2 and C3 is small. Therefore, the ammeter 62 detects a relatively small charging current value. In FIG. 5, the resistance values of the first chemical liquid M1 and the second chemical liquid M2 are very small, and are not shown in this figure.

  If there is a pinhole due to adhesion failure or the like in the partition wall 32, there is almost no electric capacity between the first chemical solution M1 and the second chemical solution M2 sandwiching the partition wall 32. As shown in the equivalent circuit of FIG. There is an electrical resistance R formed by a certain chemical. The combined capacitance formed by C1, C2 and the resistor R is larger than in the case of FIG. 5, so that the ammeter 62 detects a relatively large charging current value.

  FIG. 7 is a chart showing the results of an experiment using the detection device and the infusion bag as shown in FIGS. 1 and 2, and shows the detected current value when the electrode area and the electrode configuration are changed. In FIG. 7, “pressing application” means that a first electrode and a second electrode are respectively installed below the first chamber and the second chamber of the chemical solution bag to be measured, and a DC voltage of 10 kV is applied between both electrodes. It refers to the case where it is applied instantaneously. “Moving application” is a state in which a DC voltage of 10 kV is applied between the first electrode and the second electrode in advance, and the first chamber and the second chamber of the chemical solution bag to be measured are respectively connected to the first electrode and the second electrode. This refers to the case where the electrode is gradually moved onto the electrode. “Good” and “Good” refer to those in which the infusion bag has a good partition wall and the partition wall has no sealing failure or pinhole, and “defective product” and “defective” are infusion solutions for comparison. It refers to an infusion bag in which the partition of the bag is opened and the first chamber and the second chamber are communicated.

FIG. 7 is analyzed as follows.
(1) In both “pressing application” and “moving application”, and in both “defective product” and “good product”, the current value is large when the electrode area is large.
(2) In both “pressing application” and “moving application”, the current value in the case of “defective product” is generally larger than the current value in the case of “good product”.
(3) In the case of “pressing application”, the sensitivity (ratio of defective / good current value) is generally higher than in the case of “moving application”.
(4) In “pressing application”, when the electrode area is large, the sensitivity (ratio of defective / good current value) is high.
(5) In the form of FIG. 7, it is possible to determine the presence or absence of pinholes in the partition wall of the infusion bag with high accuracy by “pressing application” and increasing the electrode area.
The applied voltage is preferably a high voltage of 3000 volts or higher, more preferably a high voltage of 8000 volts or higher. The electrode area is set according to the outer wall area of the multi-chamber container and the dielectric breakdown distance between the electrodes, more preferably 10 cm ² or more, and about 100 cm ² is preferable in a general multi-chamber container. .

  FIG. 8 is a table showing the results of an experiment using the detection apparatus (power source is a DC voltage of 10 kV) as shown in FIG. 1 and an infusion bag (PTN Twin-2 / manufactured by Ajinomoto Pharma). In the table of FIG. 8, the open state is indicated by the diameter of the pinhole (opening width, μm) and the opening location. The “center”, “right end”, and “left end” of the opening locations correspond to the center, upper end, and lower end of the partition plane (FIG. 2), respectively. The detected value [μA] is the maximum value among the five measured values. The method for creating each opening width includes a step of strongly welding the partition wall by sandwiching a metal wire having a thickness of each opening width between the partition walls, and then extracting the metal wire. In the table of FIG. 8, the S / N ratio is the ratio of the detected value [μA] to the current value [10 μA] in the case of a non-defective product. According to the table of FIG. 8, when the opening width is 20 μm to 4000 μm, the S / N ratio is sufficiently large regardless of the opening position, and it is possible to determine whether or not there is a pinhole with high accuracy.

  FIG. 9 shows a pinhole (adhesion failure) in the partition wall 32 that can communicate between the first chamber 12 and the second chamber 22 of the infusion bag 110 using the detection device 140 of the present invention, the second chamber 22 and the third chamber. 112 is a layout diagram showing the principle of detecting pinholes in the partition walls 132 that can communicate with each other, and the infusion bag 110 is shown by a schematic cross-sectional view. The infusion bag 110 shown in FIG. 9 is disposed between the first chamber 12 that stores the chemical M1, the second chamber 22 that stores the chemical M2, the third chamber 112 that stores the chemical M3, and the first and second chambers. The partition wall 32 that can be communicated, the partition wall 132 that can be communicated between the second chamber and the third chamber, the port portion 18 for sending the drug solution from the inside of the infusion bag to the outside, and the hole 26 for suspension Is provided. The chemical liquids M1 and M2 and the chemical liquid M3 are conductive, and the first chamber, the second chamber, the third chamber, the partition wall 32, and the like are made of a flexible nonconductive resin.

  9, the infusion bag 110 is the same as the infusion bag of FIG. 1 except that the infusion bag 110 includes a third chamber containing the drug solution M3 and a partition wall 132 between the second chamber and the third chamber. The chamber 12, the second chamber 22, and the third chamber 112 form a bag-shaped space formed by firmly bonding the peripheral portions of the two overlapping non-conductive resin films 20 to each other by partition walls 32 and 132. It is formed by partitioning. The partition walls 32 and 132 are formed by adhering the upper and lower surfaces of the resin film 20 so that they can communicate with each other by a method such as heating and melting. The partition wall 32 is opened by pressing the chemical solution in the first chamber or the second chamber from the outside, whereby the first chamber and the second chamber of the infusion bag 110 are communicated, and the chemical solutions M1 and M2 are mixed. The partition wall 132 is opened by pressing the chemical solution in the second chamber or the third chamber from the outside, whereby the second chamber and the third chamber of the infusion bag 110 are communicated, and the chemical solutions M2 and M3 are mixed.

  Since the partition wall 32 is bonded with a weak adhesive force so as to communicate with each other, the partition wall 32 often includes an adhesion failure, that is, a pinhole, that allows the first chamber 12 and the second chamber 22 to communicate with each other. Similarly, since the partition wall 132 is bonded with a weak adhesive force so as to communicate with each other, the partition wall 132 often includes an adhesion failure, i.e., a pinhole, that allows the second chamber 22 and the third chamber 112 to communicate with each other. For example, M1 is a sugar / electrolyte solution, M2 is an amino acid solution, and M3 is a fat / vitamin solution.

  In the layout diagram of FIG. 9, the detection device 140 for detecting a pinhole is disposed in contact with the first electrode 42 having a metal surface disposed in contact with the outer wall 44 of the first chamber 12 and the outer wall 54 of the second chamber 22. A second electrode 52 having a metal surface, a third electrode 142 having a metal surface disposed in contact with the outer wall 144 of the third chamber 112, a DC power source 64 connected to each electrode, and an ammeter 62. The metal surface of the first electrode 42 is in contact with the outer wall 44 of the first chamber, the metal surface of the second electrode 52 is in contact with the outer wall 54 of the second chamber, and the metal surface of the third electrode 142 is in contact with the outer wall 144 of the third chamber. Are contacted, a positive voltage is applied from the DC power source 64 to the second electrode 52, and a negative voltage is applied from the DC power source 64 to the first electrode 42 and the third electrode 142 via the ammeter 62. On the basis of the current value detected by the ammeter 62, a sealing failure, that is, a pinhole in the partition wall 32 and the partition wall 132 is detected.

  In the layout diagram of FIG. 9, when neither the partition wall 32 nor the partition wall 132 has a pinhole and is a non-defective product, the ammeter shows a small current value, and either one or both of the partition wall 32 and the partition wall 132 has a pinhole. In some cases, the ammeter shows a large current value. Therefore, in the arrangement shown in FIG. 9, it is impossible to detect which partition is defective, but it is possible to determine whether or not there is a pinhole in the partition of the multi-chamber container. In an infusion bag or the like, if any of the plurality of partition walls is defective, it becomes a defective product, and thus such determination can be used. The metal surfaces of the first to third electrodes are in contact with the outer walls of the first to third chambers simultaneously and instantaneously.

In the above embodiment, since one ammeter is used in the detection device for detecting the pinhole of the partition of the multi-chamber container having three chambers, it cannot be detected which partition is defective, but the first electrode 42 If a current meter is connected between the DC power source 64 and between the third electrode 142 and the DC power source 64, it is possible to detect which partition wall is defective. Further, even if a direct current power source and an ammeter are connected between the electrodes, the object can be achieved, and pinholes in the partition walls of the multi-chamber container having three or more rooms can be detected with high accuracy.
Although the metal surface of the 1st electrode thru | or the 3rd electrode contacted the outer wall of the 1st chamber thru | or the 3rd chamber simultaneously and instantaneously, the form which can detect the sealing defect of each partition simultaneously was shown, but first the 1st electrode And the metal surface of the second electrode are instantaneously brought into contact with the outer walls of the first chamber and the second chamber to detect a sealing failure between the partition walls of the first chamber and the second chamber, and then the second electrode and the third electrode Needless to say, the metal surface can be instantaneously brought into contact with the outer walls of the second chamber and the third chamber to accurately detect the sealing failure between the partition walls of the second chamber and the third chamber.

Any material can be used for the electrode in the present invention as long as it is conductive, but examples thereof include conductive materials such as metals, carbon, and conductive resins. Preferably, it is a metal. More preferably, it is stainless steel in consideration of hygiene and corrosion resistance.
In addition, the electrode shape of the present invention includes a flat surface, a concave surface, a convex surface, or the like that is in close contact with the shape of the wall surface of the multi-chamber container.
The electrode area of the electrode of the present invention that contacts the object to be inspected is preferably as large as possible without causing disturbance, and is preferably 10 cm ² or more.

  Since the present invention is characterized in that a DC power supply is applied instantaneously, in principle, there is little dark current, the influence of disturbances affecting detection accuracy can be minimized, and a sufficient S / N ratio can be obtained. Therefore, highly accurate detection is possible with a single device. The DC voltage is applied instantaneously, but preferably rises to a predetermined voltage within 1 millisecond, more preferably within 0.1 millisecond.

  By pushing up the electrode from below and pressing the outer wall of the infusion bag, the electrode is reliably pressed by the outer wall of the infusion bag, and in addition, the outer wall of the container is pressed against the electrode of the multi-chamber container by its own weight. Adhering well, the capacitance between them is constant, and a more accurate current measurement is obtained. If the second upper surface 83 is lifted together with the electrode, the central portion is supported, so that the shape of the flexible multi-chamber container is not bent as compared with the case where only the electrode is lifted, so that good contact with the electrode is obtained. It is done. Further, by pushing up the electrode from below, unnecessary pressure is not applied to the multi-chamber container, and the risk that an unintended partition due to pressing at the time of inspection is communicated can be avoided. If the electrode in this device is placed in the transport path of the transport facility and the multi-chamber container is pressed by the rising of the electrode along with the transport of the infusion bag, the time for stopping the inspection object on the conveyor is minimized and the Inspection can be performed at high speed while transporting continuously.

The layout which shows the principle which detects the pinhole (adherence defect) in the partition which can communicate between the 1st chamber and the 2nd chamber of an infusion bag using the detection apparatus of this invention. The schematic plan view of the infusion bag which can be test | inspected with the detection apparatus of FIG. The schematic plan view of the conveyor installation in which the electrode of the detection apparatus of this invention was integrated. It is a schematic side view of the conveyor installation of FIG. It is an electrical equivalent circuit diagram which shows the principle of the detection apparatus of this invention, and is an equivalent circuit diagram which shows the state which test | inspects the infusion bag without a pinhole. It is an electrical equivalent circuit diagram which shows the principle of the detection apparatus of this invention, and is an equivalent circuit diagram which shows the state which test | inspects the infusion bag with a pinhole. It is a graph which shows the measured value of the electric current at the time of changing an electrode area and an electrode form. It is a table | surface which shows the result of one experiment using the detection apparatus and infusion bag of this invention. The pinhole in the 1st partition which can communicate between the 1st chamber and the 2nd chamber of an infusion bag using the detecting device of the present invention, and the pinhole in the 2nd partition which can communicate between the 2nd chamber and the 3rd chamber FIG.

Explanation of symbols

10: infusion bag, 12: first chamber, 14, 16: peripheral portion, 18: port portion, 22: second chamber, 24: peripheral portion, 26: hanging hole, 32: partition wall, 40: detection device, 42 : First electrode, 42 ': metal surface of the first electrode, 44: outer wall, 52: second electrode, 52': metal surface of the second electrode, 54: outer wall, 61: conducting wire, 62: ammeter, 64: DC power supply, 70: first drive shaft, 71, 73, 75, 77: first drive surface, 72, 74, 76, 78: first conveyor belt, 71 ′, 73 ′, 75 ′, 77 ′: first Driven pulley, 80: conveyor equipment, 82: first upper surface, 83: second upper surface, 84: third upper surface, 86: connecting rod, 87: crankshaft, 89, 89 ′: lifting guide, 90: second drive shaft, 91, 93, 95: second drive surface, 92, 94, 96: second conveyor belt, 91 ', 93 , 95 ': second driven pulley, 98 and 99: holder, 101: air cylinder, 112: third chamber, 132: second partition wall. 142: third electrode, 144: outer wall. C1, C2, C3: condenser, M1: first chemical solution, M2: second chemical solution, M3: third chemical solution, R: resistance.

Claims (7)

A detection device for detecting a pinhole in a partition wall of a multi-chamber container made of a flexible non-conductive resin including a partition wall disposed between at least two chambers for storing a conductive fluid and adjacent chambers. ,
An electrode having a contact surface made of at least two conductive materials, and at least one DC power source and ammeter connected to each electrode, each electrode being in contact with the outer wall of each chamber,
A detection device that detects a pinhole in a partition wall based on a current value detected by an ammeter when a voltage is instantaneously applied from the DC power source to the electrode after each electrode contacts an outer wall of each chamber. A detection device for detecting a pinhole in a partition wall of a multi-chamber container made of a flexible non-conductive resin including a partition wall disposed between at least two chambers for storing a conductive fluid and adjacent chambers. ,
An electrode having a contact surface made of at least two conductive materials, and at least one DC power source and ammeter connected to each electrode, each electrode being in contact with the outer wall of each chamber,
Detection that detects a pinhole in the partition wall based on a current value detected by an ammeter when a voltage is applied to each electrode from the DC power source and an outer wall of each electrode or each chamber is moved and brought into contact with each other instantaneously apparatus. The detection device according to claim 1, wherein the instant is within 1 millisecond. The detection device according to any one of claims 1 to 3 , wherein a contact surface of each electrode with an outer wall of each chamber is 10 cm ² or more, and the DC power supply supplies a high voltage of 3000 volts or more. The chambers of the multi-chamber container each contain an infusion component, and the partition walls communicate with each other by pressing the adjacent chambers from the outside so that the infusion components in the adjacent chambers can be mixed. 5. The detection device according to any one of 4 above. Each said electrode is a detection apparatus of any one of Claim 1 thru | or 5 arrange | positioned in the conveyance path of the conveyance facility which conveys the said multi-chamber container. The said each electrode is raised when each room | chamber of the multi-chamber container conveyed by the said conveyance equipment is located in the upper direction, Each said electrode is contacted to the outer wall of each room | chamber instantaneously. Detection device.

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