JP4301443B2 - Hair growth agent and patch containing the hair growth agent - Google Patents

Description

  The present invention relates to a hair restorer and a patch containing the hair restorer. An object of the present invention is to provide a hair growth agent excellent in transdermal absorbability and to be used by being directly applied to the skin, thereby gradually absorbing the hair growth agent over a long period of time and exhibiting an excellent hair growth effect. It is in providing the patch which can do.

It is known that “male hormone” is involved in male pattern baldness, which accounts for the majority of alopecia.
Male hormones such as testosterone are less active as they are. However, reductase 5-α-reductase is present in the sebaceous glands, and testosterone is reduced to highly active 5-α-dehydrotestosterone (DHT). Since DHT inhibits the conversion of nutrients taken up by hair matrix cells into the energy required for cell division, hair matrix cells cannot produce the energy required for cell division, which It is considered one of the causes of the disease.
Therefore, it is considered that alopecia can be prevented or treated by inhibiting the activity of 5-α-reductase that reduces male hormones such as testosterone to highly active DHT. As an inhibitor of 5-α-reductase, female hormones such as estradiol (see Patent Document 1) are known, but they have a high risk of side effects and have not been widely spread.

On the other hand, other causes of alopecia can include reduced function of hair matrix cells. If the function of the hair matrix cells can be restored to normal, it is considered that hair loss can be prevented and hair growth can be promoted.
Cell growth factors, blood circulation promoters, hair matrix cell activators, and the like are known as those that are thought to be able to normalize the function of hair matrix cells.
Known cell growth factors include dialkyl monoamine derivatives, maikai flower extract, ginkgo biloba extract, photosensitizer 301, butterfly extract, hawthorn extract, grosferrin, placenta extract, insulin-like growth factor (IGF · I), and the like. .
Known blood circulation promoters include assembly extract, tocopherol acetate, benzyl nicotinate, chili pepper, minoxidil, carpronium chloride and the like.
Known hair matrix cell activators include pentadecanoic acid glycerides and 6-benzylaminopurine (see Patent Document 2).

Japanese Patent Publication No. 6-010127 Japanese Patent No. 2636118

Most of the hair restorer compositions that are currently commercially available are used by being sprinkled on the scalp, applied to the scalp, or applied directly to the scalp. Since the active ingredient in the hair restorer composition acts on the hair matrix cells or the vicinity thereof, the hair restoration effect cannot be obtained unless the active ingredient is supplied to the hair papilla.
In order to penetrate the active ingredient of the hair-growing composition from the scalp to the hair papilla, the active ingredient must pass through the follicle side wall from the pores. However, the pores and hair follicles are in a lipophilic state due to the secreted sebum, and even if the area around the pores is cleaned by shampooing normally, the inside of the hair follicle is still clogged with sebum, The active ingredient of the hair-restoring composition that is water-soluble hardly penetrates around the hair matrix cells.

  Therefore, the conventional hair-restoring agent composition is going to acquire the hair-restoration effect by using it several times a day. However, even if the conventional hair restorer composition is used multiple times a day, the amount of active ingredient supplied to the scalp increases immediately after use, but the active ingredient cannot be supplied over a long period of time, and sufficient hair restoration is possible. It was difficult to obtain an effect. In addition, when used multiple times a day as in the conventional hair restorer composition, it may be forgotten to be used or may not be used when busy, and the conventional hair restorer composition is long. It was difficult to use continuously for a period.

  The present invention has been made to solve the above problems, and the invention according to claim 1 includes the following (A) macrocyclic synthetic musk, (B) nitro synthetic musk, (C) indane synthetic musk. And (D) a hair growth agent comprising at least one selected from the group consisting of tetralin synthetic musks.
(A) Macrocyclic synthetic musk
  Cybeton (9-cyclopentadecene-1-one), cyclopentadecanone, cyclohexadecenone (5-cyclohexadecene-1-one), cyclopentadecanolide, 12-ketocyclopentadecanolide (oxacyclohexadecane) -2,13-dione), cyclohexadecanolide, cyclohexadecenolide (7-cyclohexadecenolide), 12-oxa-16-hexadecanolide, 11-oxa-16-hexadecanolide, 10-oxa-16-hexadecanolide , Ethylene plasylate, ethylene dodecanedioate
(B) Nitro-based synthetic musk
  Musk ketone (2,6-dinitro-3,5-dimethyl-4-tert-butylbenzene), musk xylol (2,4,6-trinitro-5-tert-butylbenzene), musk ambullet (2,6-dinitro -3-Methoxy-1-methyl-4-t-butylbenzene), Muscutibeten (2,6-dinitro-3,4,5-trimethyl-t-butylbenzene), Musk Mosken (1,1,3,3,5) -Pentamethyl-4,6-dinitroindane)
(C) Indan synthetic musk
  6-acetylhexamethylindarin (6-acetyl-1,1,2,3,3,5-hexamethylindane), 4-acetyldimethyl-t-butylindarin (4-acetyl-6-t-butyl-) 1,1-dimethylindyne), 5-acetyltetramethylisopropylindane (5-acetyl-3-isopropyl-1,1,2,6-tetramethylindane)
(D) Tetralin-based synthetic musk
  6-acetylhexatetralin (6-acetyl-1,1,2,4,4,7-hexamethyltetralin), hexamethylhexahydrocyclopentabenzopyran (4,6,6,7,8,8-hexamethyl- 1,3,4,6,7,8-hexahydrocyclopentabenzopyran)
  The invention according to claim 2 is one or more selected from the group consisting of the following (A) macrocyclic synthetic musk, (B) nitro synthetic musk, (C) indane synthetic musk and (D) tetralin synthetic musk. It is related with the patch for hair growth characterized by containing.
(A) Macrocyclic synthetic musk
  Muscone (3-methylcyclopentadecanone), civetone (9-cyclopentadecene-1-one), cyclopentadecanone, cyclohexadecenone (5-cyclohexadecen-1-one), cyclopentadecanolide, 12 -Ketocyclopentadecanolide (oxacyclohexadecane-2,13-dione), cyclohexadecanolide, cyclohexadecenolide (7-cyclohexadecenolide), 12-oxa-16-hexadecanolide, 11-oxa- 16-hexadecanolide, 10-oxa-16-hexadecanolide, ethylene plasylate, ethylenedodecanedioate
(B) Nitro-based synthetic musk
  Musk ketone (2,6-dinitro-3,5-dimethyl-4-tert-butylbenzene), musk xylol (2,4,6-trinitro-5-tert-butylbenzene), musk ambullet (2,6-dinitro -3-Methoxy-1-methyl-4-t-butylbenzene), Muscutibeten (2,6-dinitro-3,4,5-trimethyl-t-butylbenzene), Musk Mosken (1,1,3,3,5) -Pentamethyl-4,6-dinitroindane)
(C) Indan synthetic musk
  6-acetylhexamethylindarin (6-acetyl-1,1,2,3,3,5-hexamethylindane) 4-acetyldimethyl-t-butylindarin (4-acetyl-6-t-butyl-1) , 1-dimethylindalin), 5-acetyltetramethylisopropylindane (5-acetyl-3-isopropyl-1,1,2,6-tetramethylindane)
(D) Tetralin-based synthetic musk
  6-acetylhexatetralin (6-acetyl-1,1,2,4,4,7-hexamethyltetralin), hexamethylhexahydrocyclopentabenzopyran (4,6,6,7,8,8-hexamethyl- 1,3,4,6,7,8-hexahydrocyclopentabenzopyran)
  The invention according to claim 3 includes a support and a base layer impregnated or laminated on the support, and the base layer includes (A) a macrocyclic synthetic musk according to claim 2, (B The present invention relates to a hair growth patch comprising one or more selected from the group consisting of :) a nitro-based synthetic musk, (C) an indane-based synthetic musk, and (D) a tetralin-based synthetic musk.

The hair restorer according to the present invention has an excellent hair growth effect. And since the hair restorer which concerns on this invention is excellent in percutaneous absorbability, it can exhibit the hair growth effect outstanding compared with the conventional hair restorer.
The patch according to the present invention can be used by directly sticking to the skin topical area, so that the hair restorer contained in the base layer can be gradually percutaneously absorbed over a long period of time, and an excellent hair restorer effect can be exhibited. Is possible. In addition, since the patch according to the present invention can be gradually percutaneously absorbed over a long period of time simply by sticking it on the skin, it can be used more easily than conventional hair restorer compositions. .

Hereinafter, the present invention will be described in detail. The patch according to the present invention contains a fragrance component having a musk-like fragrance as an essential component.
Musk, also called musk, is a dried scented secretion in the male abdomen of musk deer (Moschus moschiferus L.). Musk commerce is prohibited by the Washington Convention and is very expensive.

In this invention, the fragrance | flavor component which has a musk-like fragrance is an active ingredient of a hair restorer. The present inventors experimentally found that a perfume component having a musk-like aroma has a hair-growth effect, as shown in Test Examples described later. In particular, an excellent hair-growth effect can be exhibited by percutaneously absorbing a fragrance component having a musk-like fragrance from the skin local area.
Although musk can be used as a fragrance component having a musk-like fragrance, musk is very expensive and it is difficult to stably secure the required amount for a long period of time. use. A synthetic musk is a chemical synthesis of a perfume component contained in a musk, a chemical synthesis of a perfume component having an aroma similar to a musk, or a perfume component having a structure similar to a perfume component contained in a musk. They are synthesized and both have a musk-like aroma.
Specific examples of synthetic musks include macrocyclic synthetic musks, nitro synthetic musks, indane synthetic musks, and tetralin synthetic musks.

  As the macrocyclic synthetic musk, muscone (3-methylcyclopentadecanone) represented by (1) in Chemical Formula 1, sibetone (9-cyclopentadecene-1-one) represented by (2) in Chemical Formula 1, 1, cyclopentadecanone represented by (3), cyclohexadecenone (5-cyclohexadecen-1-one) represented by chemical formula (4), cyclopentadecanolide represented by chemical formula (5) 12-ketocyclopentadecanolide (oxacyclohexadecane-2,13-dione) represented by (6) in Chemical Formula 1, cyclohexadecanolide represented by (7) in Chemical Formula 2, (8) ), 12-oxa-16-hexadecanolide represented by chemical formula (9), and 11-oxa-16-hexadecene represented by chemical formula (10). Exemplifying nolide, 10-oxa-16-hexadecanolide shown in (11) of Chemical Formula 2, ethylene plasylate shown in (12) of Chemical Formula 2, ethylenedodecanedioate shown in (13) of Chemical Formula 2 Can do.

  Examples of the nitro musk include musk ketone (2,6-dinitro-3,5-dimethyl-4-tert-butylbenzene) represented by chemical formula (1) and musk xylol represented by chemical formula (2) (2). , 4,6-trinitro-5-t-butylbenzene), musk emblet (2,6-dinitro-3-methoxy-1-methyl-4-t-butylbenzene) represented by (3) of Chemical formula 3, Muscutibeten (2,6-dinitro-3,4,5-trimethyl-t-butylbenzene) represented by (3) in Chemical Formula 3, Musk Mosken (1,1,3,3,3) represented by (5) in Chemical Formula 3 5-pentamethyl-4,6-dinitroindane) and the like.

  Examples of the indane musk include 6-acetylhexamethylindarin (6-acetyl-1,1,2,3,3,5-hexamethylindane) represented by chemical formula (1) and chemical formula (2). 4-acetyldimethyl-t-butylindarin (4-acetyl-6-t-butyl-1,1-dimethylindalin) represented by formula (5), 5-acetyltetramethylisopropylindane (3) represented by formula (3) 5-acetyl-3-isopropyl-1,1,2,6-tetramethylindane) and the like.

  Examples of tetralin-based musks include 6-acetylhexatetralin (6-acetyl-1,1,2,4,4,7-hexamethyltetralin) represented by chemical formula (4) and chemical formula (5). Hexamethylhexahydrocyclopentabenzopyran (4,6,6,7,8,8-hexamethyl-1,3,4,6,7,8-hexahydrocyclopentabenzopyran) and the like can be exemplified. .

In the present invention, among the synthetic musks described above, one type of synthetic musk can be used alone, or a mixture of two or more types of synthetic musks can be used.
The synthetic musk described above is blended in the base layer to be described later to be a patch according to the present invention, but the content of the synthetic musk in the base layer is not particularly limited, but per 100 parts by weight of the base layer 0.0001 to 10 parts by weight, preferably 0.001 to 7 parts by weight, and more preferably 0.01 to 5 parts by weight. If the amount is less than 0.0001 parts by weight, it is difficult to exhibit the hair-growth effect. If the amount exceeds 10 parts by weight, not only a further hair-growth effect can be obtained, but a musk-like fragrance becomes strong.

  The patch according to the present invention contains a synthetic musk which is an active ingredient. By containing the active ingredient of the hair restorer in the patch, a certain amount of the active ingredient can be gradually percutaneously absorbed over a long period of time, so that an excellent hair restoring effect can be obtained.

The patch according to the present invention comprises a support and a base layer laminated or impregnated on the support, and a synthetic musk as an active ingredient is contained in the base layer.
The support body should just be a support body used for a normal patch, for example, a non-stretchable or stretchable film, a nonwoven fabric, a knitted fabric etc. can be illustrated.
Support materials include polyethylene, polyester, polypropylene, polyethylene terephthalate, polybutylene terephthalate, polyethylene naphthalate, polystyrene, nylon, cotton, rayon, rayon / polyethylene terephthalate, polyacrylonitrile, polyvinyl alcohol, acrylic resin, polyurethane, styrene. -Isoprene-styrene block copolymer, styrene-butadiene-styrene block copolymer, styrene-ethylene-propylene-styrene block copolymer, styrene-butadiene rubber, ethylene-vinyl acetate copolymer, cellophane, etc. Can do.
A polymer film can be laminated on the support. Examples of the polymer film include polyethylene, polypropylene, polyester, polyamide, polyvinyl alcohol, polyvinyl chloride, polyvinylidene chloride, polyurethane, polystyrene, ethylene-vinyl acetate copolymer, and polycarbonate.
The thickness of the support is not particularly limited, but is 1 μm to 1 cm, more preferably 100 μm to 1000 μm.

The support is laminated or impregnated with a base layer. The base layer has excellent adhesion to the skin surface, is easy to apply to the skin, and has excellent solubility of the active ingredient, and can be gradually released to absorb the active ingredient. is there. In the present invention, any base layer of a general patch can be used.
Specifically, a base layer composed of an adhesive or a water-soluble polymer can be exemplified.

Adhesives include rubber adhesives, vinyl acetate adhesives, ethylene-vinyl acetate adhesives, vinyl chloride adhesives, acrylic adhesives, polyamide adhesives, polyethylene adhesives, polysulfide adhesives, etc. It can be illustrated.
When the base layer is composed of a pressure-sensitive adhesive, the content of the pressure-sensitive adhesive is not particularly limited, but is 5 to 50 parts by weight, preferably 10 to 40 parts by weight, more preferably 15 to 35 parts per 100 parts by weight of the base layer. Parts by weight.

Examples of water-soluble polymers include natural polymers, semi-synthetic polymers, and synthetic polymers.
Examples of the natural polymer include gelatin, starch, agar, glucomannan, alginic acid or a salt thereof, gum arabic, tragacanth gum, locust bean gum, gum acacia, guar gum, carrageenan and the like.

  Examples of the semisynthetic polymer include methyl cellulose, methyl cellulose sodium, ethyl cellulose, hydroxyethyl cellulose, carboxymethyl cellulose, carboxymethyl cellulose sodium, and dextrin.

  Examples of synthetic polymers include polyacrylic acid or salts thereof, polyvinyl alcohol, polyvinyl pyrrolidone, polyvinyl methacrylate, methyl vinyl ether-maleic anhydride copolymer, carboxyvinyl polymer, polyethylene oxide, isobutylene-maleic anhydride copolymer, etc. can do.

The water-soluble polymer described above may be treated with a known crosslinking agent or polymerization agent. Moreover, the water-soluble polymer mentioned above can mix | blend 1 type, or 2 or more types.
When the base layer is composed of a water-soluble polymer, the content of the water-soluble polymer is 1 to 20 parts by weight, preferably 3 to 15 parts by weight, more preferably 5 to 10 parts per 100 parts by weight of the base layer. Parts by weight.

  Furthermore, in the present invention, water, a solubilizer, a transdermal absorption promoter, a moisturizer, a skin irritation relieving agent, a surfactant and the like can be blended in the base layer as necessary.

  When water is contained in the base layer, the water content is 20 to 80 parts by weight, preferably 30 to 70 parts by weight, and more preferably 40 to 60 parts by weight per 100 parts by weight of the base layer.

Soluble agents include oleic acid, propylene carbonate, propylene glycol, polyethylene glycol, isopropyl myristate, butyl myristate, isopropyl palmitate, cetyl palmitate, butyl stearate, isocetyl stearate, diethyl sebacate, diisopropyl sebacate, linol Examples thereof include ethyl acid, isopropyl linoleate, methyl salicylate, glycol benzyl alcohol salicylate, N-methyl-2-pyrrolidone, oleyl alcohol, dimethyl sulfoxide, peppermint oil, eucalyptus oil, castor oil, limonene and the like.
When mix | blending a solubilizer, the 1 type (s) or 2 or more types of the above-mentioned solubilizers can be mix | blended.
The content of the dissolving agent is 0.01 to 10 parts by weight, preferably 0.05 to 7 parts by weight, more preferably 0.1 to 5 parts by weight, per 100 parts by weight of the base layer.

As a transdermal absorption enhancer, diisopropyl adipate, lecithin, squalane, squalene, azone, menthol, polyethylene glycol, isopropyl myristate, crotamiton, mint oil, eucalyptus oil, limonene, oleic acid, diisopropyl adipate linoleate, dimethyl sulfoxide, etc. It can be illustrated.
When blending a percutaneous absorption enhancer, one or more of the percutaneous absorption enhancers described above can be blended.
The content of the transdermal absorption enhancer is 0.01 to 10 parts by weight, preferably 0.05 to 7 parts by weight, more preferably 0.5 to 5 parts by weight per 100 parts by weight of the base layer.

Examples of the humectant include glycerin, sorbitol, lactic acid, urea, propylene glycol, ethylene glycol, diethylene glycol, triethylene glycol, polyethylene glycol, 1,3-butylene glycol and the like.
When mix | blending a moisturizer, the 1 type (s) or 2 or more types of the moisturizer mentioned above can be mix | blended.
The content of the humectant is 10 to 70 parts by weight, preferably 20 to 60 parts by weight, more preferably 30 to 55 parts by weight per 100 parts by weight of the base layer.

Skin irritants include diphenhydramine hydrochloride, diphenhydramine tannate, chlorferamine maleate, pheniramine maleate, amlexanox, ibucilast, azelastine, oxatomide, cromoglycate, tazanolast, terfenadine, tranilast, ketotifen fumarate, levirinast, glycyrrhizin Examples thereof include glycyrrhetinic acid and cyclodextrin.
When mix | blending a skin irritation reducing agent, the 1 type (s) or 2 or more types of the skin irritation reducing agents mentioned above can be mix | blended.
The content of the skin irritation mitigating agent is 0.01 to 10 parts by weight, preferably 0.05 to 7 parts by weight, more preferably 0.1 to 5 parts by weight per 100 parts by weight of the base layer.

Surfactants include polyoxyethylene glycol fatty acid ester, propylene glycol fatty acid ester, glycerin fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyglycerin fatty acid ester, sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene sorbit fatty acid Examples include ester, polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil, polyoxyethylene sterol, polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene alkyl ether, polyoxyethylene alkylphenyl ether, and the like.
When mix | blending surfactant, the 1 type (s) or 2 or more types of the surfactant mentioned above can be mix | blended.
The content of the surfactant is 0.01 to 10 parts by weight, preferably 0.05 to 7 parts by weight, more preferably 0.1 to 5 parts by weight per 100 parts by weight of the base layer.

  Furthermore, in the present invention, an antioxidant such as ascorbic acid, stearic acid ester, gallic acid ester, etedate, dibutylhydroxytoluene, butylhydroxyanisole, and a preservative such as thymol, benzalkonium chloride, paraben, etc. PH adjusters such as phosphoric acid, boric acid, citric acid, acetic acid, malic acid, tartaric acid, lactic acid, sodium hydroxide, diethanolamine, triethanolamine, diisopropanolamine, kaolin, titanium oxide, talc, bentonite, zinc oxide, Tackifiers such as inorganic powders such as montmorillonite and silicic anhydride, polybutene, natural latex, vinyl acetate emulsion, polyacrylic ester emulsion, and polyacrylic acid emulsion can be arbitrarily blended as appropriate.

  It is desirable to cover and protect the exposed surface of the base layer with a release layer. The release layer is not particularly limited as long as it can be easily peeled off from the base layer at the time of use. Examples thereof include films of polyester, polyvinyl chloride, polyvinylidene chloride, polyethylene terephthalate, and the like.

The patch according to the present invention is used after being applied to the skin topic. The patch applied to the skin top can release the compound with musk-like fragrance, which is an active ingredient contained in the base layer, gradually over a long period of time to absorb the active ingredient, and has excellent hair growth effect Can be demonstrated.
The application location of the patch according to the present invention is not particularly limited, and can be suitably applied to all parts of the human body such as the head, arms, legs, waist, and shoulder.

  EXAMPLES Hereinafter, although this invention is demonstrated based on an Example, this invention is not limited to these Examples at all. In addition, a compounding quantity is weight%.

(Sample preparation)
Using each of the bases composed of the following composition and the synthetic musk described in Table 1 and a support made of a woven fabric made of polyethylene having a thickness of 100 μm, each patch of the examples according to a conventional method. Prepared. In addition, the patch of the control example which does not contain a synthetic musk at all was prepared similarly.
<Base composition>
Sodium polyacrylate 5.0
Sodium carboxymethylcellulose 3.0
Tartaric acid 0.5
D-sorbitol 20
Glycerin 20
Gelatin 3.0
Aluminum hydroxide 0.5
Methylparaben 0.1
Purified water
Synthetic musk 0.35
Total 100.0% by weight

(Test example)
For each adolescent male aged 18 to 40 years, apply each patch cut into a circle with a circumference of 3 cm on the left shoulder (change the applied patch twice a day in the morning and evening) And the increase / decrease in the number of hairs at the location where the patch was applied 3 months after the start of the test was examined and evaluated according to the following evaluation criteria. The results are listed in Table 1.
<Evaluation criteria>
The increase rate of hair before and after the test was 60% or more. ... A
The increase rate of hair before and after the test was 45 to 60%. ..B
The increase rate of hair before and after the test was 30 to 45%. ..C
The increase rate of hair before and after the test was 0 to 30%. ... D
The increase rate of the hair before the start of the test and after the end of the test was 0%.・ ・ ・ ・ ・ ・ E

As shown in Table 1, an increase in the number of hairs was confirmed in the samples of each Example blended with the synthetic musk. On the other hand, in the control sample containing no synthetic musk, no significant increase in the number of hairs was confirmed, confirming that the synthetic musk had a hair-growth effect.

Claims (3)

  It is characterized by comprising at least one selected from the group consisting of the following (A) macrocyclic synthetic musk, (B) nitro synthetic musk, (C) indane synthetic musk and (D) tetralin synthetic musk. Hair restorer.
(A) Macrocyclic synthetic musk
  Cybeton (9-cyclopentadecene-1-one), cyclopentadecanone, cyclohexadecenone (5-cyclohexadecene-1-one), cyclopentadecanolide, 12-ketocyclopentadecanolide (oxacyclohexadecane) -2,13-dione), cyclohexadecanolide, cyclohexadecenolide (7-cyclohexadecenolide), 12-oxa-16-hexadecanolide, 11-oxa-16-hexadecanolide, 10-oxa-16-hexadecanolide , Ethylene plasylate, ethylene dodecanedioate
(B) Nitro-based synthetic musk
  Musk ketone (2,6-dinitro-3,5-dimethyl-4-tert-butylbenzene), musk xylol (2,4,6-trinitro-5-tert-butylbenzene), musk ambullet (2,6-dinitro -3-Methoxy-1-methyl-4-t-butylbenzene), Muscutibeten (2,6-dinitro-3,4,5-trimethyl-t-butylbenzene), Musk Mosken (1,1,3,3,5) -Pentamethyl-4,6-dinitroindane)
(C) Indan synthetic musk
  6-acetylhexamethylindarin (6-acetyl-1,1,2,3,3,5-hexamethylindane), 4-acetyldimethyl-t-butylindarin (4-acetyl-6-t-butyl-) 1,1-dimethylindyne), 5-acetyltetramethylisopropylindane (5-acetyl-3-isopropyl-1,1,2,6-tetramethylindane)
(D) Tetralin-based synthetic musk
  6-acetylhexatetralin (6-acetyl-1,1,2,4,4,7-hexamethyltetralin), hexamethylhexahydrocyclopentabenzopyran (4,6,6,7,8,8-hexamethyl- 1,3,4,6,7,8-hexahydrocyclopentabenzopyran)   One or more types selected from the group consisting of the following (A) macrocyclic synthetic musk, (B) nitro synthetic musk, (C) indane synthetic musk and (D) tetralin synthetic musk are contained. A characteristic hair patch.
(A) Macrocyclic synthetic musk
  Muscon (3-methylcyclopentadecanone), civeton (9-cyclopentadecene-1-one), cyclopentadecanone, cyclohexadecenone (5-cyclohexadecen-1-one), cyclopentadecanolide, 12 -Ketocyclopentadecanolide (oxacyclohexadecane-2,13-dione), cyclohexadecanolide, cyclohexadecenolide (7-cyclohexadecenolide), 12-oxa-16-hexadecanolide, 11-oxa- 16-hexadecanolide, 10-oxa-16-hexadecanolide, ethylene plasylate, ethylenedodecanedioate
(B) Nitro-based synthetic musk
  Musk ketone (2,6-dinitro-3,5-dimethyl-4-tert-butylbenzene), musk xylol (2,4,6-trinitro-5-tert-butylbenzene), musk ambullet (2,6-dinitro -3-Methoxy-1-methyl-4-t-butylbenzene), Muscutibeten (2,6-dinitro-3,4,5-trimethyl-t-butylbenzene), Musk Mosken (1,1,3,3,5) -Pentamethyl-4,6-dinitroindane)
(C) Indan synthetic musk
  6-acetylhexamethylindarin (6-acetyl-1,1,2,3,3,5-hexamethylindane), 4-acetyldimethyl-t-butylindarin (4-acetyl-6-t-butyl-) 1,1-dimethylindyne), 5-acetyltetramethylisopropylindane (5-acetyl-3-isopropyl-1,1,2,6-tetramethylindane)
(D) Tetralin-based synthetic musk
  6-acetylhexatetralin (6-acetyl-1,1,2,4,4,7-hexamethyltetralin), hexamethylhexahydrocyclopentabenzopyran (4,6,6,7,8,8-hexamethyl- 1,3,4,6,7,8-hexahydrocyclopentabenzopyran)   It comprises a support and a base layer impregnated or laminated on the support, wherein the base layer comprises (A) a macrocyclic synthetic musk, (B) a nitro-based synthetic musk, (C (1) One or more types selected from the group consisting of indane-based synthetic musk and (D) tetralin-based synthetic musk are contained.