JP4452875B2 - Arterial blood vessel detection device, pressure pulse wave detection device, and arteriosclerosis evaluation device - Google Patents

Description

  The present invention is an arterial blood vessel detection device for detecting an artery under the skin using light, a pressure pulse wave detection device for detecting a pressure waveform that is an internal pressure of the artery under the skin, and a light receiving element thereof. The present invention relates to an arteriosclerosis evaluation apparatus that determines an arteriosclerosis evaluation index based on the detected signal and a signal detected by a pressure detection element.

  Various attempts have been proposed to collect pressure pulse waves in living arteries and to evaluate the heart function, pulse wave velocity, blood vessel hardness, peripheral circulation, organ circulation, etc. from the pressure pulse waves. ing. For example, in the pressure pulse wave detection device described in Patent Document 1, when the artery is pressed by a pressing surface in which a large number of pressure detection elements (sensor arrays) are embedded, the pressure detection element that outputs the largest signal is the optimal position. The pressure pulse wave detected by the pressure detection element at the optimum position is output.

However, in the pulse wave detection device having a pressing surface in which a large number of pressure detection elements are embedded as described above, a bridge including a pressure-sensitive resistor is used as a pressure detection element by heavily using photolithography on a semiconductor substrate. Since advanced processing and measurement techniques are required for each configuration, the cost increases. In addition, since the relationship between the pressure detection element and the blood vessel is unclear, there is a limit in measurement accuracy.
Japanese Patent Laid-Open No. 08-015440 Japanese Patent Application Laid-Open No. 08-049733

  The present invention has been made against the background of the above circumstances, and the object of the present invention is to provide an arterial blood vessel detection device that can easily detect the blood vessel position of a subcutaneous artery, a structure that is simple and highly accurate. An object of the present invention is to provide a pressure pulse wave detection device capable of measuring a pulse wave and an arteriosclerosis evaluation device capable of easily evaluating arteriosclerosis of a living body.

  As a result of various studies on the background of the above circumstances, the present inventors have found that when light of a predetermined wavelength is incident from the light emitting element on the skin to the portion where the artery is present under the skin, The reflected light reflected by the tube wall is detected by the light receiving element arranged on the light emitting element side, and at the same time, the reflected light is inverted by the light receiving element arranged on the opposite side of the light emitting element with the artery as a boundary. We found that waveform arterial vascular transmitted light was detected, and started to analyze the phenomenon using a theoretical simulation. The present invention has been made based on such findings.

That is, the invention according to claim 1, that is, the gist of the first invention is an arterial blood vessel detection device for detecting the position of a blood vessel placed on the skin of a living body and existing under the skin, a) a body disposed on the skin of the living body; and (b) a light emitting element provided on one surface of the body so as to emit light of a predetermined wavelength toward the skin of the living body; A first reflected light receiving element provided adjacent to the light emitting element on one surface of the main body in order to receive the first reflected light from the vessel wall of the blood vessel existing under the skin; and (d) the lower skin to receive the light transmitted through the blood vessels present in a position sandwiching the vessel during the one surface of the body from the light emitting element and the first reflected light receiving element with a predetermined distance spaced apart and the light emitting element a transmitted light receiving element provided, the calling in one aspect of the (e) said body Is provided between the element and the transmitted light receiving element, and a pressure detection element to be pressed against the blood vessel is to contain.

  The gist of the invention according to claim 2 is that, in the first invention, the light emitting element is located on a line parallel to a major axis direction of the blood vessel passing through the first reflected light receiving element on one surface of the main body. And a second reflected light receiving element that receives the second reflected light from the vessel wall of the blood vessel and is located on the opposite side of the first reflected light receiving element.

The gist of the invention according to claim 3 is that, in the first invention, the first reflected light detected by the first reflected light receiving element or the second reflected light detected by the second reflected light receiving element. And a position parameter calculating means for calculating a position parameter indicating a position in the crossing direction with respect to the long axis of the artery based on the transmitted light detected by the transmitted light receiving element.

The gist of the invention according to claim 4 is that, in the first invention, based on the position parameter calculated by the position parameter calculation means, the position of the main body in the crossing direction with respect to the major axis of the artery is determined. Display control means for displaying on the display device is further included.

The gist of the invention according to claim 5 is that, in the first invention, (a) a positioning device that drives and positions the main body in a crossing direction of the long axis of the artery; and (b) the pressure detecting element. And a radial drive control means for controlling the positioning device based on the position parameter calculated by the position parameter calculation means so that is positioned directly above the artery.

The gist of the invention according to claim 6 is that, in the first invention, (a) a rotation angle changing device for changing a rotation angle of the main body around an axis perpendicular to the skin, and (b) the first First reflected light detected by the first reflected light receiving element and the second reflected light receiving element so that a line passing through the first reflected light receiving element and the second reflected light receiving element is parallel to the major axis of the blood vessel. And rotation angle control means for controlling the rotation angle changing device based on the second reflected light.

The invention according to claim 7 , that is, the gist of the second invention, is: (a) any one of the pressure pulse wave detecting devices related to the second invention, and (b) a pressure detecting element of the pressure pulse wave detecting device. A blood pressure value determining means for determining a blood pressure value of the living body based on a pressure pulse wave corresponding to the pressure in the artery detected by (c), and (c) detected by the first reflected light receiving element of the pulse wave detecting device Based on the amplitude of the first reflected light, the second reflected light detected by the second reflected light receiving element, or the transmitted light detected by the transmitted light receiving element, the blood vessel diameter corresponding to the blood vessel diameter change of the artery A blood vessel diameter change parameter calculating means for calculating a change parameter; and (d) an artery based on the pulse pressure of the blood pressure value determined by the blood pressure value determining means and the blood vessel diameter change parameter calculated by the diameter change parameter calculating means. Dynamics that determine the cure index A pulse hardening evaluation index determining means.

In the invention according to claim 1, that is, the first invention, the arterial blood vessel detection device is arranged on the skin of the living body to detect the position of the blood vessel existing under the skin. (B) a light-emitting element provided on one surface of the body so as to emit light of a predetermined wavelength toward the skin of the living body, and (c) a blood vessel existing under the skin. In order to receive the first reflected light from the tube wall, the first reflected light receiving element provided adjacent to the light emitting element on one surface of the main body, and (d) transmitted through the blood vessel existing under the skin to receive the transmitted light, the transmitted light receiving element provided at positions sandwiching the vessel during the one surface of the body from the light emitting element and the first reflected light receiving element with a predetermined distance spaced apart and the light emitting element If, (e) and the light emitting element in one surface of the body transmitted light receiving element Provided between, since it contains a pressure sensing element to be pressed against the blood vessel, the relative position with respect to the artery under the skin on the basis of the transmitted light and transmitted through the first reflected light and the blood vessels from the tube wall of the vessel Since it is detected, the position of the arterial blood vessel is easily detected and positioning with respect to the artery is facilitated. Further, the pressure pulse wave detecting device is the arterial blood vessel detecting device according to the first invention, wherein the pressure detecting element to be pressed by the blood vessel is disposed between the light emitting element and the transmitted light receiving element on one surface of the main body. Since it is provided, the pressure detecting element can be positioned right above the artery, so that the structure is simplified and the pressure pulse wave can be measured with high accuracy.

  In the invention according to claim 2, the arterial blood vessel detection device is located on a line parallel to the major axis direction of the blood vessel passing through the first reflected light receiving element on one surface of the main body and sandwiching the light emitting element. Since it further includes a second reflected light receiving element that is located on the opposite side of the first reflected light receiving element and receives the second reflected light from the vessel wall of the blood vessel, for example, the first reflected light and the second reflected light are included. And the center line (optical sensor axis) of the main body can be orthogonal to the long axis of the artery.

In a third aspect of the present invention, the pressure pulse wave detector includes a first reflected light detected by the first reflected light receiving element or a second reflected light detected by the second reflected light receiving element; Based on the transmitted light detected by the transmitted light receiving element, the apparatus further includes a position parameter calculating means for calculating a position parameter indicating a position in the crossing direction with respect to the long axis of the artery. Thus, the relative position between the artery and the main body can be known.

In the invention according to claim 4 , the pressure pulse wave detection device uses the position parameter calculated by the position parameter calculation means to display the position of the main body in the crossing direction with respect to the long axis of the artery. Since it further includes display control means for displaying, the pressure detection element can be easily positioned on the artery by displacing the main body while looking at the position displayed on the display by the display control means.

In the invention which concerns on Claim 5 , a pressure pulse wave detection apparatus is (a) the positioning apparatus which drives and positions the said main body in the crossing direction of the long axis of the said artery, (b) The said pressure detection element is the said artery. Further including radial drive control means for controlling the positioning device based on the position parameter calculated by the position parameter calculation means so that the pressure detection element is located on the artery. Thus, the main body is automatically positioned by the radial direction drive control means.

In the invention according to claim 6 , the pressure pulse wave detection device comprises: (a) a rotation angle changing device that changes a rotation angle around an axis perpendicular to the skin of the main body; and (b) the first reflected light. The first reflected light and the second reflected light detected by the first reflected light receiving element and the second reflected light receiving element so that a line passing through the light receiving element and the second reflected light receiving element is parallel to the long axis of the blood vessel. Rotation angle control means for controlling the rotation angle changing device based on the reflected light, the rotation angle control means rotates the main body until the first reflected light and the second reflected light have the same intensity, for example. By controlling the rotation angle changing device as described above, the center line (optical sensor axis) of the main body can be automatically made orthogonal to the long axis of the artery.

In the invention according to claim 7 , that is, the second invention, the arteriosclerosis evaluation device comprises: (a) any one of the pressure pulse wave detection devices related to the second invention, and (b) the pressure of the pressure pulse wave detection device. A blood pressure value determining means for determining a blood pressure value of the living body based on a pressure pulse wave corresponding to the pressure in the artery detected by the detecting element; and (c) detected by the first reflected light receiving element of the pulse wave detecting device. Corresponding to the blood vessel diameter change of the artery based on the amplitude of the first reflected light, the second reflected light detected by the second reflected light receiving element, or the transmitted light detected by the transmitted light receiving element A blood vessel diameter change parameter calculating means for calculating a blood vessel diameter change parameter; and (d) a blood pressure value determined by the blood pressure value determining means and a blood vessel diameter change parameter calculated by the blood vessel diameter change parameter calculating means. Based on arteriosclerosis assessment finger Since the arteriosclerosis evaluation index determining means for determining the number is included, the arteriosclerosis of the living body can be evaluated non-invasively and easily.

  Hereinafter, an embodiment of the present invention will be described in detail with reference to the drawings. FIG. 1 is a block diagram illustrating a circuit configuration of an arteriosclerosis evaluation apparatus 8 including an arterial blood vessel detection apparatus or a pressure pulse wave detection apparatus to which the present invention is applied.

  In FIG. 1, a pressure pulse wave detection device 10 is attached to a part of a living body such as a patient or a measurement subject, for example, the upper arm 12 and non-invasively detects a pressure pulse wave in the brachial artery 22 under the skin of the upper arm 12. And a pressure pulse wave detection probe 14 mounted on the upper arm 12 by a mounting band 16. As shown in detail in the bottom view of the main part of FIG. 2 and the cross-sectional view of the main part of FIG. 3, the pressure pulse wave detection probe 14 is connected to the mounting band 16 so A sensor housing 18 having a container shape, a sensor 20 housed in the sensor housing 18 and supported through a diaphragm 19 so as to be able to enter and exit from the opening of the sensor housing 18, and the sensor 20 in the radial direction, that is, the brachial artery 22 A pair of bellows 24 and 26, which are actuators interposed between the sensor housing 18 and the sensor 20 in order to move in a direction perpendicular to the major axis of the sensor, are provided.

As shown in detail in FIG. 3, the sensor 20 includes a sensor case 30 to which the center portion of the diaphragm 19 is fixed, and a main body provided to be rotatable relative to the sensor case 30 around a vertical axis C _1. 32, and an electric motor 31 provided in the sensor case 30 to change its angular position by driving the main body 32 about a vertical axis C _1. A male screw 34 fixed to the output shaft of the electric motor 31 is screwed into a bracket 36 fixed to the main body 32, and the angular position of the main body 32 is changed according to the rotation of the output shaft. The electric motor 31, the male screw 34, the bracket 36, and the like constitute a rotation angle changing device 38.

On the pressing surface 40 of the main body 32, a light emitting element 42, for example, a strain formed from an LED that outputs monochromatic light of, for example, about 800 nm along the center line that is the center in the width direction, that is, the optical sensor axis C _2. A pressure detection element 44 including a semiconductor pressure detection element such as an electric bridge including a resistance element, a pressure diode, and a pressure transistor, and a transmitted light receiving element 46 are sequentially arranged. Pressure detection element 44 is disposed in the intermediate (middle) position between the optical sensor axis on C ₂ and the light emitting element 42 and the transmitted light receiving element 46. Further, in the above-mentioned pressing surface 40, as shown in FIG. 4, a the longitudinal axis, parallel lines C ₄ to line C ₃ indicating a long axis direction of the street and the brachial artery 22 of the pressure detection element 44 A first reflected light receiving element 48 and a second reflected light receiving element 50 are disposed at positions adjacent to the pressure detecting element 44 with the pressure detecting element 44 interposed therebetween. The transmitted light receiving element 46 receives the transmitted light transmitted through the brachial artery (blood vessel) 22 existing under the skin 28, and the light emitting element 42 and the first second reflected light on the pressing surface (one surface) of the main body 32. The brachial artery (blood vessel) 22 is provided at a position spaced apart from the light receiving elements 48 and 50 by a predetermined distance and between the light emitting element 42 and the first and second reflected light receiving elements 48 and 50.

  Under the skin 28, light incident from the light emitting element 42 is reflected by the tube wall of the brachial artery 22 as shown by an arrow (solid line) in FIG. 3, and a part of the reflected light is received by the first reflected light. Light is received by the element 48 and the second reflected light receiving element 50. Further, a part of the light incident from the light emitting element 42 passes through the tube of the brachial artery 22 as shown by an arrow (broken line) in FIG. 3 and is received by the transmitted light receiving element 46. At this time, it is repeated that the brachial artery 22 becomes large diameter (thick) or small diameter (thin) in synchronization with the pulse. Since the first reflected light and the second reflected light received by the first reflected light receiving element 48 and the second reflected light receiving element 50 are smaller in distance and larger in intensity as the brachial artery 22 becomes larger in diameter. 5, the signal waveform changes in synchronization with the pulsation of the diameter of the brachial artery 22, that is, the blood pressure waveform. On the other hand, the transmitted light received by the transmitted light receiving element 46 becomes longer as the brachial artery 22 has a larger diameter and the amount of absorption increases and the intensity decreases. Therefore, as shown in the lower part of FIG. Furthermore, the pulsation of the diameter of the brachial artery 22, that is, a signal waveform that is inverted and changed to a blood pressure waveform.

  Returning to FIG. 1, the electronic control device 60 includes a CPU 62, a ROM 64, a RAM 66, an A / D converter 70, and the like. The CPU 62 processes an input signal stored in advance in the ROM 64 while using the temporary storage function of the RAM 66, and an LED drive circuit 68 that drives and controls the light emitting element 42, and a rotary motor drive circuit 72 that drives and controls the electric motor 31. The pressure control valve drive circuit 74 for driving and controlling the pressure control valve 73, the position control valve drive circuit 76 for driving and controlling the position control valve 75, and the display 78 are controlled. The pressure control valve 73 uses the pressure from the pump 80 that pumps compressible or incompressible fluid as the original pressure, and the pressure in the airtight space formed by the sensor housing 18 and the diaphragm 19 is the electronic control device 60. To control the pressing force of the sensor 20 against the skin 28. The pump 80, the pressure control valve 73, the sensor housing 18, the diaphragm 19, and the like constitute a pressing device 98 for pressing the pressure detection element 44 provided on the pressing surface 40 of the main body 32 against the brachial artery 22. The position control valve 75 controls the radial position of the sensor 20 by adjusting the pressure difference between the pair of bellows 24 and 26 in accordance with a command from the electronic control unit 60 using the pressure from the pump 80 as a source pressure. These position control valve 75, pump 80, bellows 24 and 26, etc. constitute a positioning device 94 that determines the radial position of the main body 32.

FIG. 6 is a functional block diagram for explaining a main part of the control operation of the electronic control device 60. In FIG. 6, the first signal reading means 82 includes a first reflected light signal R ₁ indicating the first reflected light and the second reflected light detected by the first reflected light receiving element 48 and the second reflected light receiving element 50, and read the second reflected light signal R ₂ sequentially. The rotation angle drive control means 84 sequentially controls the electric motor 31 so that the magnitude, for example, the amplitude or effective value of the first reflected light signal R ₁ and the second reflected light signal R ₂ are equal to each other. The center line, that is, the optical sensor axis C ₂ is perpendicular to the line C ₃ indicating the longitudinal direction of the brachial artery 22.

The second signal reading means 86 indicates the first reflected light signal R ₁ indicating the first reflected light detected by the first reflected light receiving element 48 or the second reflected light detected by the second reflected light receiving element 50. The second reflected light signal R ₂ and the transmitted light signal T indicating the transmitted light received by the transmitted light receiving element 46 are sequentially read. Area calculating means 88, for example, transmitted to the area M ₁ of them first one period of the reflected light signal R ₁ based on the first reflected light signal R ₁ and the transmission optical signal T read by the second signal reading means 86 The area M ₂ of one cycle of the optical signal T is sequentially calculated. The area M ₁ and the area M ₂ are obtained by integrating the sizes of time discrete data points indicating the first reflected light signal R ₁ and the transmitted light signal T. The position parameter calculation means 90 sequentially calculates the area ratio R _S (%) [= 100 × M ₁ / (M ₁ + M ₂ )] based on the area M ₁ and the area M ₂ , for example. The area ratio R _S is an amount corresponding to a position parameter representing the relative position of the pressure detection element 44 on the main body 32 with respect to the brachial artery 22. If the area ratio R _S is, for example, 50%, the pressure detecting element 44 is positioned directly above the brachial artery 22. If the area ratio R _S is greater than 50%, the brachial artery 22 is positioned at a position lower than the pressure detecting element 44. 1 shows the state of movement to the first reflected light receiving element 48 and the second reflected light receiving element 50 side, and when it is smaller than 50%, the brachial artery 22 moves to the transmitted light receiving element 46 side from the position directly below the pressure detecting element 44. Shows the state.

Based on the area ratio R _S corresponding to the position parameter, the radial drive control unit 92 moves the main body 32 in the radial direction, that is, the direction orthogonal to the brachial artery 22 so that the brachial artery 22 is located immediately below the pressure detecting element 44. Move to. For example, the radial direction drive control means 92 is set so that the area ratio R _S coincides with the target value of 50%, or within a predetermined target range centered on 50%, for example, within a range of 40 to 60%. Then, the position control valve 75 is controlled to position the main body 32 in a direction perpendicular to the brachial artery 22. The display control means 100 causes the display 78 to display the position in the crossing direction with respect to the brachial artery 22 of the main body 32 based on the area ratio R _S corresponding to the position parameter. For example, as shown in FIG. 7, the display 78 has a central position display unit 110 for indicating a state in which the pressure detection element 44 is located immediately above the brachial artery 22. The left position display unit 112 for indicating a state in which the brachial artery 22 is positioned closer to the transmitted light receiving element 46 than the pressure detection element 44, the pressure detection element 44 is on the right side of the brachial artery 22, that is, the brachial artery 22 is the pressure detection element 44. The display control means 100 is provided with a right side position display unit 114 for indicating a state of being located closer to the light emitting element 42, and the display control means 100 has an area ratio R _S within a predetermined target range, for example, within a range of 40 to 60%. If there is, the center position display unit 110 is lit and displayed. If the area ratio R _S is lower than the lower limit value of the target range, for example, 40%, the left position display unit 114 is lit and the area ratio When R _S exceeds the upper limit value of the target range, for example, 60%, the right position display unit 114 is turned on.

  The pressing force control means 96 controls the pressing control valve 98 based on a signal from the pressure detection element 44. For example, the pressure pulse wave detected by the pressure detection element 44 in the process of changing the pressing force of the pressure detection element 44 positioned directly above the brachial artery 22 by controlling the radial position and the rotation angle position of the main body 32. The optimum pressing force with the maximum amplitude is determined, and the pressing force of the main body 32 is held at the optimum pressing force during the blood pressure measurement period based on the pressure pulse wave.

The blood pressure value determining means 102 determines the minimum blood pressure value of the living body based on the actual lower peak value (minimum value) and upper peak value (maximum value) of the pressure pulse wave detected by the pressure detection element 44 from the relationship obtained in advance. Determine BP _DIA (mmHg) and systolic blood pressure BP _SYS (mmHg). As said relationship, what was calibrated to the value measured using the cuff by the oscillometric blood pressure measuring device is used suitably. The blood vessel diameter change parameter calculating means 104 is configured to transmit the first reflected light signal R ₁ detected by the first reflected light receiving element 48, the second reflected light signal R ₂ detected by the second reflected light receiving element 50, or the transmitted light. Based on the amplitude of the transmitted light signal T detected by the light receiving element 46, the blood vessel diameter change parameter corresponding to the diameter change of the brachial artery 22 is calculated. The amplitude value A of the first reflected light signal R ₁ , the second reflected light signal R ₂ , or the transmitted light signal T indicates the change in the vascular diameter of the brachial artery 22, that is, the displacement of the tube wall.

The arteriosclerosis evaluation index determining means 106 includes a pulse pressure PP (= BP _SYS −BP _DIA ) that is a difference between the systolic blood pressure value BP _SYS and the systolic blood pressure value BP _DIA determined by the blood pressure value determining means 102, and a change in blood vessel diameter. The arteriosclerosis evaluation index is determined based on the amplitude value A corresponding to the displacement of the vessel wall of the brachial artery 22 indicated by the blood vessel diameter change parameter calculated by the parameter calculation unit 104. As the arteriosclerosis evaluation index, the displacement A / PP of the tube wall per unit pressure change or its reciprocal is used. The A / PP is large when the brachial artery 22 is highly flexible, but the A / PP is small when the brachial artery 22 is hard.

FIG. 8 is a flowchart for explaining a main part of the control operation of the electronic control device 60. In FIG. 8, in a step (hereinafter, step is omitted) S1 corresponding to the first signal reading means 82, the first reflected light detected by the first reflected light receiving element 48 and the second reflected light receiving element 50 and The first reflected light signal R ₁ and the second reflected light signal R ₂ indicating the second reflected light are sequentially read. Next, in the rotation angle drive control means 84 corresponding to S2, the size for example amplitude or effective value of the first reflected light signal R ₁ and the second reflected light signal R ₂ is the electric motor 31 to be equal to each other The center line of the pressing surface 40 of the main body 32, that is, the optical sensor axis C ₂ is controlled to be orthogonal to the line C ₃ indicating the major axis direction of the brachial artery 22.

In S3 corresponding to the second signal reading means 86, the first reflected light signal R ₁ or the second reflected light signal R ₂ and the transmitted light signal T indicating the transmitted light received by the transmitted light receiving element 46 are read. It is. In S4 corresponding to the area calculating means 88, for example, the area M ₁ of the first reflected light signal R ₁ and the area M ₂ of the transmitted light signal T is sequentially calculated. Then, step S5 corresponding to the positional parameter calculation means 90, which first based on the area M ₁ of the reflected light signal R ₁ and the area M ₂ of the transmitted light signal T, the area ratio R _S corresponding to the position parameters (%) [= 100 × M ₁ / (M ₁ + M ₂ )] is calculated.

Next, in S6, it is determined whether or not the area ratio R _S is within a preset target range. This target range is a range between a lower limit value R _L set to 40% and an upper limit value R _U set to 60%, for example. If it is determined in S6 that the area ratio R _S is smaller than the lower limit value R _L , the first reflected light receiving element 48 is moved closer to the brachial artery 22 in S7 corresponding to the radial drive control means 92. The position control valve 75 is controlled so that the main body 32 is moved. Next, in S8 corresponding to the display control means 100, the left position display section 112 of the display 78 is turned on to show a state where the brachial artery 22 is located on the transmitted light receiving element 46 side with respect to the pressure detecting element 44. It is done. On the other hand, if it is determined in S6 that the area ratio R _S is larger than the upper limit value R _U , the first reflected light receiving element 48 is separated from the brachial artery 22 in S9 corresponding to the radial drive control means 92. The position control valve 75 is controlled so that the main body 32 is moved in the direction to be moved. Next, in S10 corresponding to the display control means 100, the right position display unit 114 is turned on to show a state where the brachial artery 22 is located on the light emitting element 42 side with respect to the pressure detecting element 44.

When the area ratio R _S falls within the preset target range by the operation of S6 to S10 and the determination of S6 is affirmed, in S11 corresponding to the pressing force control means 96 and the display control means 100, the display device is displayed. When the central position display unit 78 is turned on, the state in which the pressure detection element 44 is positioned right above the brachial artery 22 is displayed. At the same time, the pressing force when the pressure pulse wave signal detected by the pressure detecting element 44 has the maximum amplitude is determined as the optimum pressing force against the skin 28 of the sensor 20, and the pressing force is maintained at the optimum pressing force. The Next, in S12 corresponding to the blood pressure value determining means 102, the lower peak value (minimum value) and upper peak value (maximum value) of the actual pressure pulse wave signal detected by the pressure detection element 44 from the relationship obtained in advance. Based on the above, the minimum blood pressure value BP _DIA and the maximum blood pressure value BP _{SYS of} the living body are determined. Subsequently, in S 13 corresponding to the blood vessel diameter change parameter calculation means 104, the first reflected light signal R ₁ detected by the first reflected light receiving element 48 and the second reflection detected by the second reflected light receiving element 50. Based on the optical signal R ₂ or the amplitude A of the transmitted light signal T detected by the transmitted light receiving element 46, the blood vessel diameter change parameter corresponding to the blood vessel diameter change of the brachial artery 22 is calculated. In S14 corresponding to the arteriosclerosis evaluation index determining means 106, the pulse pressure PP (= BP _SYS −BP _DIA ) which is the difference between the maximum blood pressure value BP _SYS and the minimum blood pressure value BP _DIA determined in S12 is obtained. Based on the amplitude value A corresponding to the displacement of the tube wall of the brachial artery 22 indicated by the blood vessel diameter change parameter determined in S13, the arteriosclerosis evaluation index, for example, the displacement A / PP of the tube wall per unit pressure change is determined. Are displayed on the display 78.

  As described above, according to the present embodiment, in order to detect the position of the brachial artery 22 located on the skin 28 of the living body and existing under the skin 28, (a) the skin (skin) 28 of the living body A main body 32 disposed above, and (b) a light emitting element 42 provided on a pressing surface (one surface) 40 of the main body 32 so as to emit light having a predetermined wavelength, for example, 800 nm toward the skin 28 of the living body. (C) First reflected light provided adjacent to the light emitting element 42 on the pressing surface 40 of the main body 32 in order to receive the first reflected light from the tube wall of the brachial artery 22 existing under the skin 28. A light receiving element 48; and (d) a predetermined light from the light emitting element 42 and the first reflected light receiving element 48 on the pressing surface 40 of the main body 32 in order to receive the transmitted light transmitted through the brachial artery 22 existing under the skin 28. Spaced apart and its light emitting element 42 and Since an arterial blood vessel detecting device including a transmitted light receiving element 46 provided at a position sandwiching the brachial artery 22 between the first reflected light receiving element 48 and the first reflected light receiving element 48 is provided, Since the relative position of the pressure detecting element 44 with respect to the brachial artery 22 below the skin 28 is detected based on the reflected light and the transmitted light that has passed through the blood vessel, the position of the brachial artery 22 is easily detected, and the brachial artery is detected. Positioning with respect to 22 becomes easy.

Further, according to the present embodiment, the arterial blood vessel detection device is located on the line C ₄ parallel to the longitudinal direction of the brachial artery 22 passing through the first reflected light receiving element 48 on the pressing surface 40 of the main body 32 and Since it further includes a second reflected light receiving element 50 that is positioned opposite to the first reflected light receiving element 48 across the light emitting element 42 and receives the second reflected light from the tube wall of the brachial artery 22, For example, the center line (photosensor axis) C ₂ of the pressing surface 40 of the main body 32 is orthogonal to the brachial artery 22 by rotating the main body until the first reflected light and the second reflected light have the same intensity. be able to.

  In addition, according to the present embodiment, the pressure pulse wave detecting device 10 includes a light emitting element on the pressing surface 40 of the main body 32, the pressure detecting element 44 for pressing against the brachial artery 22 in the arterial blood vessel detecting device. Since the pressure detecting element 44 is positioned directly above the brachial artery 22, the structure is simplified and the pressure pulse wave can be measured with high accuracy. Can do.

Further, according to the present embodiment, the pressure pulse wave detection device 10 includes the first reflected light detected by the first reflected light receiving element 48 or the second reflected light detected by the second reflected light receiving element 50; Based on the transmitted light detected by the transmitted light receiving element 46, it further includes a position parameter calculating means 90 for calculating a position parameter indicating the position of the brachial artery 22 in the crossing direction with respect to the major axis of the brachial artery 22, that is, an area ratio R _S. Therefore, the relative position between the brachial artery 22 and the main body 32, that is, the pressure detecting element 44 can be known using the position parameter, that is, the area ratio R _S.

Further, according to the present embodiment, the pressure pulse wave detection device 10 is configured such that the main body 32 intersects the major axis of the brachial artery 22 based on the position parameter calculated by the position parameter calculation means 90, that is, the area ratio R _S. Since the display control means 100 for displaying the position of the direction on the display 78 is further included, the pressure detection element 44 can be manually operated by shifting the main body 32 while looking at the position displayed on the display 78 by the display control means 100. Can be easily positioned on the brachial artery 22.

In addition, according to the present embodiment, the pressure pulse wave detection device 10 includes (a) a positioning device 94 that drives and positions the main body 32 in the crossing direction of the long axis of the brachial artery 22, and (b) a pressure detection element 44. Further includes radial drive control means 92 for controlling the positioning device 94 based on the position parameter calculated by the position parameter calculation means 90, that is, the area ratio R _S , so that is positioned just above the brachial artery 22. Thus, the main body 32 is automatically positioned by the radial drive control means 92 so that the pressure detecting element 44 is positioned on the brachial artery 22.

In addition, according to the present embodiment, the pressure pulse wave detection device 10 includes (a) a rotation angle changing device 38 that changes the rotation angle around the axis C ₁ perpendicular to the skin 28 of the main body 32, and (b) the second. The first reflected light receiving element 48 and the second reflected light receiving element 50 detect the line C ₄ passing through the first reflected light receiving element 48 and the second reflected light receiving element 50 in parallel with the brachial artery 22. Rotation angle control means 84 for controlling the rotation angle changing device 38 based on the first reflected light and the second reflected light, the rotation angle drive control means 84 is equivalent to, for example, the first reflected light and the second reflected light. By controlling the rotation angle changing device 38 so as to rotate the main body until the intensity becomes equal, the center line (photosensor axis) C ₂ of the main body 32 is automatically orthogonal to the long axis of the brachial artery 22. Can do.

Further, the arteriosclerosis evaluation device 8 of the present embodiment includes (a) the pressure pulse wave detection device 10 described above and (b) the brachial artery 22 detected by the pressure detection element 44 of the pressure pulse wave detection device 10. A blood pressure value determining means 102 for determining the minimum blood pressure value BP _DIA and the maximum blood pressure value BP _SYS of the living body based on the pressure pulse wave corresponding to the pressure; and (c) the first reflected light receiving element 48 of the pulse wave detecting device 10. The diameter change of the brachial artery 22 based on the amplitude A of the first reflected light detected by the second reflected light detected by the second reflected light receiving element 50 or the transmitted light detected by the transmitted light receiving element 46 A blood vessel diameter change parameter calculation means 104 for calculating a blood vessel diameter change parameter corresponding to the blood pressure value, and (d) a blood pressure PP determined by the blood pressure value determination means 102 and the blood vessel diameter change parameter calculation means 104 Blood vessel diameter change para Data, that is, an arteriosclerosis evaluation index, for example, an arteriosclerosis evaluation index determining means 106 for determining the tube wall displacement A / PP per unit pressure change based on the amplitude A indicating the displacement of the tube wall. Atherosclerosis can be assessed non-invasively and easily.

  As mentioned above, although one Example of this invention was described based on drawing, this invention is applied also in another aspect.

For example, in the above-described embodiment, the area ratio R _S between the first reflected light signal R ₁ and the transmission term signal T is used as the blood vessel position parameter calculated by the position parameter calculation unit 90. Alternatively, it may be an amplitude ratio or an amplitude difference between the first reflected light signal R ₁ and the transmission term signal T. Further, the second reflected light signal R ₂ may be used instead of the first reflected light signal R ₁ .

  In the above-described embodiment, the pressure pulse wave detected by the pressure detection element 44 is used to determine the blood pressure value. However, the difference in the propagation time of the artery between the two parts of the living body and the pulse wave obtained therefrom. It may be used for determining the propagation speed PWV and the amplitude increase index AI.

In the above-described embodiment, the first and second reflected light signals R ₁ and R ₂ and the transmitted light signal T for obtaining the position parameter and the blood vessel diameter change parameter, or the brachial pulse wave for obtaining the blood pressure and the time difference. May be obtained from a pulse wave of one beat, or may be obtained using a mean value or the like from a pulse wave of a preset time interval or a preset number of beats.

  The pressure pulse wave detection device 10 described above detects the pressure pulse wave of the brachial artery 22. However, the subcutaneous arteries of other parts such as the carotid artery, the radial artery, the dorsal artery, and the superficial temporal artery. It may be used for such as.

  In the pressure pulse wave detection device 10 described above, one of the first reflected light receiving element 48 and the second reflected light receiving element 50 provided on the pressing surface 40 of the main body 32 may be removed. In this case, the rotation angle changing device 38 and the rotation angle drive control means 84 are not necessary.

  In the above-described embodiment, when used as the pressure pulse wave detection device 10, the blood pressure value determining means 102, the blood vessel diameter change parameter calculating means 104, and the arteriosclerosis evaluation index determining means 106 are not necessarily required.

  As mentioned above, although the Example of this invention was described in detail based on drawing, this is an embodiment to the last, and this invention is implemented in the aspect which added various change and improvement based on the knowledge of those skilled in the art. Can do.

1 is a block diagram illustrating a circuit configuration of an arteriosclerosis evaluation apparatus including an arterial blood vessel detection apparatus or a pressure pulse wave detection apparatus according to an embodiment of the present invention. It is a bottom view which shows the opening part of the pressure pulse wave detection probe of FIG. It is a principal part of the pressure pulse wave detection probe of FIG. 1, Comprising: It is a fragmentary sectional view which shows the cross section of the sensor of use condition. It is a figure explaining the state by which the pressing surface of the main body of the pressure pulse wave detection apparatus of FIG. 1 was pressed by skin. The signal waveform of the first reflected light signal R ₁ detected by the first reflected light detection element provided on the pressing surface of the main body of the pressure pulse wave detection device of FIG. 1 and the transmitted light signal T detected by the transmitted light detection element. Respectively. It is a functional block diagram explaining the principal part of the control function of the electronic control apparatus of FIG. 1. A part of the display of FIG. 1, which is lit to indicate the relative position between the brachial artery under the skin and the pressure detection element of the pressure pulse wave detection device, the center position display part, the right position It is a figure which shows a display part. It is a flowchart explaining the principal part of the control action of the electronic controller of FIG.

Explanation of symbols

8: Arteriosclerosis evaluation device 10: Pressure pulse wave detection device 22: Brachial artery (artery)
28: Skin 32: Body 38: Rotation angle changing device 40: Pressing surface (one surface)
42: light emitting element 44: pressure detecting element 46: transmitted light receiving element 48: first reflected light receiving element 50: second reflected light receiving element 60: electronic calculation control device 78: display 84: rotation angle control means 90: Position parameter calculation means 92: radial drive control means 94: positioning device 84: time difference calculation means 86: heart disease determination means 100: display control means 102: blood pressure value determination means 104: diameter change parameter calculation means 106: arteriosclerosis evaluation index Decision means

Claims (7)

An arterial blood vessel detection device for detecting a position of a blood vessel placed on the skin of a living body and existing under the skin,
A main body disposed on the skin of the living body;
A light emitting element provided on one surface of the main body so as to emit light of a predetermined wavelength toward the skin of the living body;
A first reflected light receiving element provided adjacent to the light emitting element on one surface of the main body in order to receive the first reflected light from the vessel wall of the blood vessel existing under the skin;
To receive the light transmitted through the blood vessels that are present under the skin, the blood vessels between the predetermined distance spaced and luminescent element from the light emitting element and the first reflected light receiving element in one side of the body A transmitted light receiving element provided at a sandwiched position;
A pressure detecting element provided between the light emitting element and the transmitted light receiving element on one surface of the main body and pressed against the blood vessel;
An arterial blood vessel detection device comprising:   One surface of the main body is positioned on a line parallel to the long axis direction of the blood vessel passing through the first reflected light receiving element and on the opposite side of the first reflected light receiving element with the light emitting element interposed therebetween, The arterial blood vessel detection device according to claim 1, further comprising a second reflected light receiving element for receiving the second reflected light from the tube wall. Based on the first reflected light detected by the first reflected light receiving element or the second reflected light detected by the second reflected light receiving element and the transmitted light detected by the transmitted light receiving element, pulse wave detecting apparatus according to claim 1 is intended to include positional parameter calculating means for calculating the positional parameters indicating the position of the cross direction relative to the artery. 4. The pressure pulse wave detection device according to claim 3 , further comprising display control means for displaying a position of the main body in a direction intersecting with the major axis of the artery on a display based on the position parameter calculated by the position parameter calculation means. A positioning device for driving and positioning the body in the crossing direction of the artery;
As the pressure detecting element is positioned right above the artery, according to claim 3 and a radial drive control means for controlling the positioning device based on the positional parameters calculated by the positional parameter calculating means, it is intended to include Pressure pulse wave detector. A rotation angle changing device for changing a rotation angle around an axis perpendicular to the skin of the main body;
The first reflected light detected by the first reflected light receiving element and the second reflected light receiving element so that a line passing through the first reflected light receiving element and the second reflected light receiving element is parallel to the blood vessel; The pressure pulse wave detection device according to any one of claims 1 to 5 , further comprising: a rotation angle control unit that controls the rotation angle changing device based on the second reflected light. A pressure pulse wave detecting apparatus according to any one of claims 1 to 6,
A blood pressure value determining means for determining a blood pressure value of the living body based on a pressure pulse wave corresponding to the pressure in the artery detected by the pressure detecting element of the pressure pulse wave detecting device;
First reflected light detected by the first reflected light receiving element of the pressure pulse wave detection device, second reflected light detected by the second reflected light receiving element, or transmitted light detected by the transmitted light receiving element Blood vessel diameter change parameter calculating means for calculating a blood vessel diameter change parameter corresponding to the blood vessel diameter change of the artery based on the amplitude of
An arteriosclerosis evaluation index determining means for determining an arteriosclerosis evaluation index based on the pulse pressure of the blood pressure value determined by the blood pressure value determining means and the blood vessel diameter change parameter calculated by the blood vessel diameter change parameter calculating means; An arteriosclerosis evaluation apparatus comprising:

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