JP4501025B2 - Skin tick control agent - Google Patents

Description

The present invention relates to a skin acaricide used to insecticidal skin mites

  Recent studies have discovered skin mites such as Demodex Brevis and Demodex Folicolorum. These skin mites live under the skin, such as sebaceous glands and hair roots, absorb nutrients such as sebum and damage cells, causing acne, rough skin, reduced skin metabolic function, and hair loss. For this reason, the removal of skin mites is one of the effective means for healing skin diseases and preventing hair loss.

Moon peach is said to be a substance that can control skin ticks. This moon peach has the scientific name Alpinia zerumbet cv. It is a plant belonging to the genus Gingaeaceae, which is a Variegata, and is distributed in subtropical climate areas such as the Ryukyu Islands. It has been known for a long time that moon peach has an insecticidal action and an antibacterial action. For this reason, it is used, for example, for wrapping and storing foodstuffs. When moon peach is used to control skin mites, essential oil is obtained from dried rhizome rhizomes, and this moon peach essential oil is blended into hair shampoos, hair tonics and the like. And, by using these to wash and style the hair, insects and insects that live on the scalp are killed and exterminated.
JP 2001-302411 A

  Moon peach essential oil is irritating because the raw moon peach is a ginger family plant, and it is considered that this irritant component will effectively act to control skin mites. However, with such moon peach essential oil, it is easy to induce skin diseases such as rough skin by continuing to use because of irritation, and even if it can control skin mites, It has skin problems and needs to be treated.

  In addition, skin mites have a short period of time of about 1 week until they become adults and many eggs are laid. Therefore, they can be controlled only after repeated use. On the other hand, as described above, the highly irritating moon peach essential oil is not suitable for repeated use. Thus, even if moon peach essential oil can control skin mites, it can only be controlled by temporary use. For this reason, the moon peach essential oil also has the problem which cannot remove a skin tick completely.

The present invention has been made in view of such conventional problems, and is less irritating to the skin and can be used repeatedly. By repeatedly using it, skin mites are reliably removed. It is an object of the present invention to provide a skin mite control agent capable of being treated.

Skin acaricides of the invention of claim 1, cypress water, Benibanaeki scan, U micro plum beetle oil, arnica extract, linden extract, horsetail extract, Hypericum extract, sage extract, yarrow extract, Zegna Oy extract, chamomile extract, and toe officinalis It contains a mixture of extracts as an active ingredient.

Skin acaricide as described in claim 1, together have a repellent efficacy against skin mites, irritation to the skin has a nil or small characteristics. Accordingly, repeated use does not induce skin diseases such as rough skin. Moreover, since it has the repellent effect of skin mites, it acts to gradually kill skin mites by repeated use. Therefore, by repeatedly using such a compound described in claim 1, it is possible to prevent the growth and egg laying of skin mites and to completely control skin mites.

Skin acaricides of the present invention, cypress water, safflower extract, c micro plum beetle oil, A Runikaekisu, linden extract, horsetail extract, Hypericum extract, sage extract, yarrow extract, Zegna Oy extract, chamomile extract, a mixture of Toukinsenkaekisu It is contained as an active ingredient.

  Cypress water is an aromatic oil extracted from cypress dry materials and leaves, and is used as a natural fragrance in cosmetics, soaps, and the like. The safflower extract is an oil and fat obtained from safflower seeds, and is used as an edible oil and fat, as well as in cosmetics and medicines. Sea buckthorn oil is used as a therapeutic agent for visceral diseases and a blood circulation improving agent.

  Arnica extract, linden extract, horsetail extract, hypericum extract, sage extract, Achillea millefolium extract, mallow extract, chamomile extract, and ginseng extract are all plant extract extracts used in cosmetics.

  Arnica extract is obtained by extraction from Arnica flower or root, linden extract is obtained by extraction from linden tree flower or leaf, Hypericum extract is obtained by extraction from Hypericum flower or leaf, sage extract Is obtained by extraction from sage grass. Achillea millefolium extract is obtained by extraction from Achillea millefolium grass, mallow extract is obtained by extraction from leaves or flowers of Uzbek mallow, chamomile extract is obtained by extraction from chamomile flowers, Obtained by extraction from flowers of eucalyptus.

As a result of many experiments and examinations by the inventor of the present invention, the above-described compounds have been found to have an effect of killing skin mites. This skin mite insecticide is because these compounds have the ability to repel skin mites, and does not kill skin mites in a short time, but acts to kill skin mites in a long time. In addition, these compounds are all approved for use in cosmetics, drugs or foods, are mild to the skin and are safe. The inventor has also verified this point. As a result of experiments conducted by the present inventor, it has been found that the above-mentioned compounds have the property of not inducing skin diseases even when used repeatedly on the skin .

In skin acaricides of the present invention, it uses a multi several more compounds as active ingredients, at the same time use it is enabled to more than use one of the compounds. It is because the utility of each compound becomes synergistic by using multiple types.

In consideration of the use mode of the skin such as viscosity, irritation to the skin by repeated use, or cost, it is preferable to dilute and use the compound so as to obtain a predetermined blending ratio. This blending ratio is appropriately changed according to the compound. For example, 0.1% to 12% by weight for cypress water, 0.01% to 1% by weight for safflower extract, and 0.001% to 1 % by weight for sea buckthorn oil are good. .

  The same applies to the arnica extract, linden extract, horsetail extract, hypericum extract, sage extract, sorghum extract, mallow extract, chamomile extract, and capsicum extract. , 0.001% to 1% by weight, cedar extract is 0.001% to 1% by weight, hypericum extract is 0.001% to 1% by weight, sage extract is 0.001% to 1% by weight %, Achillea millefolium extract is 0.001 wt% to 1 wt%, Xenopus extract is 0.001 wt% to 1 wt%, Chamomile extract is 0.001 wt% to 1 wt%, A range of 0.001% to 1% by weight is good.

  Arnica extract, linden extract, horsetail extract, hypericum extract, sage extract, yarrow extract, mallow extract, chamomile extract, capsicum extract are also used in the form of a mixture of these (hereinafter referred to as plant extract extract mixture) Can do. This is because these compounds exhibit a synergistic effect when mixed. In the case of a mixture, these may be blended in equal amounts or in different blending ratios. In addition, as a compounding ratio of each extract in a plant extract extract mixture, the range of 0.001 weight%-1 weight% is favorable.

The skin acaricides of the present invention, cypress water, Benibanaeki scan, U micro plum beetle oil, arnica extract, linden extract, horsetail extract, Hypericum extract, sage extract, yarrow extract, Zegna Oy extract, a mixture of chamomile extract and Toukinsenkaekisu Can be used in combination. With the combination of these compounds, it becomes possible to carry out extremely effective skin mite control, as shown in the examples described later.

  The diluent for the above compound is appropriately selected in consideration of the solubility of the compound. In the case of oil solubility, it is diluted with an oil or alcohol, and in the case of water solubility, distilled water is used. Dilute with purified water or alcohol. These diluents are selected to have low skin irritation and good skin wettability.

  For example, in the case of oils, vegetable oils such as olive oil, coconut oil, peanut oil, castor oil, rice bran oil, animal oils such as egg yolk oil, and other oils can be used. In the case of alcohol, ethyl alcohol, isopropyl alcohol, and other liquid alcohols can be used.

  In this case, an oil agent, alcohol, and water may be used in combination, and a thickener such as polyvinyl alcohol, dextrin, methylcellulose, carrageenan, and arginine may be added, or a vitamin agent and a hormone agent may be added. By adding a thickener, the adhesion to the skin is improved and the effect on skin mites can be maintained for a long time. By adding vitamins and hormones, the skin can be replenished.

  The application of the skin mite control agent to the skin is performed so that the control agent adheres to the skin, and can be performed by an appropriate means such as application, spray spraying, and immersion. In this way, the skin mites that live on the skin can be killed by simply attaching the skin mite control agent to the skin. In addition, when the skin tick repellent is attached to the skin, the penetration of the repellent into the skin can be promoted by stroking the skin surface with a finger or the like, thereby further improving the insecticidal effect of the skin mite. be able to.

  In addition, the application of the skin mite control agent to the skin is preferably performed by repeated use on the skin. As described above, the skin mite control agent has the ability to repel skin mites and gradually exerts an insecticidal effect on the skin mites. As repeated use, it is preferable to use it every day, but it may be used every other day.

  In the present invention, the above-mentioned skin mite control agent can be blended with an external base. By blending in an external base, it can be used as it is, and can be supplied as a product.

  As the external base, the above-mentioned water, oil and alcohol can be used. In addition, cosmetics and ointments can be used as a base for external use. As cosmetics, basic cosmetics such as lotion, milky lotion, cream, shampoo, rinse, cleansing agent, pack agent, soap and the like are good, but finished cosmetics such as foundation may also be used. When cosmetics are used as a base for external use, it becomes a habitual use, and therefore, it is used repeatedly. Therefore, insects of skin mites can be reliably killed.

  As an ointment, the material used for the base of an external medicine can be used. For example, an ointment in which fatty acids, waxes, squalene, etc. are mixed as materials can be used.

  As an external base, it is also possible to use a hair restorer and a bath agent. Hair restorer is a kind of cosmetics, and by blending in hair restorer, skin mite extermination acts in addition to the nutritional effect of hair restorer, and therefore hair loss caused by skin mite can be prevented. Moreover, it can be made to act when a pore expands at the time of bathing by mix | blending with a bath agent. That is, since the skin mite control agent can easily enter the pores, the skin mites that live in the pores can be effectively killed.

  Next, description will be made with reference to a formulation example when cosmetics are used as a base for external use.

Formulation Example 1 (for cosmetic cream)
a. Skin tick control agent Hinoki water 1.2% by weight
Safflower extract 0.1% by weight
Sea buckthorn oil 0.01% by weight
Plant extract extract (equal mix) 0.01% by weight
b. Cream base 1,3-butylene glycol (BG) 18.0% by weight
Glycerin 12.0% by weight
Squalane 4.0 wt%
Auroylglutamate di (phytosteryl 35.0% by weight
/ Octildodecyl)
Cypress water 1.2% by weight
Carbomer 0.2% by weight
(Acrylic acid / alkyl acrylate (C10 0.1 wt%
-30) copolymers)
Methylparaben 0.1% by weight
Propylparaben 0.1% by weight
Tocophenol 0.2% by weight
Roman chamomile oil 0.2% by weight
Arginine 0.1% by weight
Etidylene acid 4Na 0.1% by weight
Oat extract 0.08% by weight
Purified water residue

Formulation Example 2 (for lotion)
a. Skin tick control agent Hinoki water 1.2% by weight
Safflower extract 0.1% by weight
Sea buckthorn oil 0.001% by weight
Plant extract extract (equal mix) 0.01% by weight
b. Lotion base BG 8.0% by weight
Glycerin 3.4% by weight
Betaine 2.0% by weight
Methylparaben 0.1% by weight
Ethylparaben 0.1% by weight
Citric acid 0.05% by weight
Sodium citrate 0.02% by weight
Roman chamomile oil 0.01% by weight
Hydrogenated castor oil 0.01% by weight
Purified water residue

Formulation Example 3 (Shampoo)
a. Skin tick control agent Hinoki water 1.2% by weight
Safflower extract 0.1% by weight
Sea buckthorn oil 0.01% by weight
Plant extract extract (equal mix) 0.01% by weight
b. Shampoo base Laureth sulfate TEA 8.0% by weight
Laureth sulfate Na 5.0 wt%
Cocamidopropyl betaine 3.0% by weight
Lauramine oxide 1.0% by weight
Salicylic acid 0.1% by weight
EDTA-2Na 0.1% by weight
Methylparaben 0.2% by weight
Citric acid 0.1% by weight
Polyquaternium-10 0.1% by weight
Isopropanol 0.1% by weight
Sodium chloride 0.1% by weight
Sodium lauroyl glutamate 0.08% by weight
Glucose distearate 0.1% by weight
Roma chamomile oil 0.2% by weight
BG 0.5% by weight
Purified water residue
(Test Example 1)

  Skin mites were collected by collecting a certain amount of skin sebum from the skin nose of each subject using the subjects as samples. The skin was sprayed with 0.1% by weight cypress water diluted in water, 0.01% by weight safflower extract diluted in water, and 0.001% by weight plant extract extract diluted in water. The time to mite death was measured. Sample A is a 30-year-old man, Sample B is a 35-year-old woman, Sample C is a 35-year-old man, Sample D is a 36-year-old man, and Sample E is a 39-year-old woman. Table 1 lists the time to death of all skin mites. “Leave” is the time when the image is left as it is.

  As is apparent from Table 1, it is possible to kill skin ticks by bringing the skin tick control agent of this Example into contact with skin ticks.

Moreover, the skin mite control agent of Table 1 was impregnated in the tape, and it affixed on the skin of the sample AE mentioned above. The state of sticking was continued for 12 hours, 24 hours, and 3 days, and the influence on the skin was examined. As a result, no skin diseases such as red spots and sores occurred in any specimen. Thereby, it was found that the above-mentioned skin mite control agent has low irritation to the skin and high safety. Therefore, even if used repeatedly, there is no induction of skin diseases such as rough skin.
(Test Example 2)

In the same manner as in Test Example 1 , skin tick was collected by collecting a certain amount of skin sebum from the skin nose of the specimen (subject). In this example, the cypress water, safflower extract, and plant extract mixture used in Test Example 1 was mixed, and the composite extract was further mixed with 0.001% by weight of Umeuro-Umeodori oil diluted in water. The sample was used as a sample. Then, these samples were sprayed on the collected skin mites and the time until the death of skin mites was measured. Sample F is a 30 year old male, Sample G is a 31 year old female, Sample H is a 35 year old male, Sample I is a 36 year old male, and Sample J is a 39 year old female. Table 2 lists the time to death of all skin mites.

  As is clear from Table 2, in the case of a complex extract in which cypress water, safflower extract and a plant extract mixture are mixed, it takes a certain amount of time to remove skin mites. In some cases, it is possible to shorten the time for skin tick control. Thereby, it turns out that skin mite control is performed more effectively by the blending of Umuro buckthorn oil.

Moreover, the skin mite control agent of Table 2 was impregnated in the tape, and it affixed on the skin of the test substance FJ mentioned above. The state of sticking was continued for 12 hours, 24 hours, and 3 days, and the influence on the skin was examined. As a result, no skin diseases such as red spots and sores occurred in any specimen. Thereby, it was found that the above-mentioned skin mite control agent has low irritation to the skin and high safety. Therefore, even when repeatedly used, there is no induction of skin diseases such as rough skin.
(Test Example 3)

In the same manner as in Test Example 1 , skin tick was collected by collecting a certain amount of skin sebum from the skin nose of the specimen (subject). Then, the time until the skin mite was killed was measured by spraying it on the collected skin mite with a concentration of 0.001% by weight diluted in water. Sample K is a 30-year-old man, Sample L is a 35-year-old woman, Sample M is a 35-year-old man, Sample N is a 36-year-old man, and Sample O is a 39-year-old woman. Table 3 lists the time to death of all skin mites.

  As is clear from Table 3, it is possible to effectively remove skin ticks even with a single Umellium oil.

  In addition, the tape was impregnated with the above-described concentration of Umeuro dome oil and adhered to the skin of the specimens K to O described above. The state of sticking was continued for 12 hours, 24 hours, and 3 days, and the influence on the skin was examined. As a result, no skin diseases such as red spots and sores occurred in any specimen. As a result, the sea buckthorn oil is less irritating to the skin, has a high level of safety, and does not induce skin diseases such as rough skin even when used repeatedly.

In this example, skin mites were collected by collecting a certain amount of skin sebum from the skin nose of the specimen (subject). Then, the number of skin mites is counted, and the mixture ratio of the cypress water, safflower extract, sea buckthorn oil and plant extract used in the skin lotion shown in Formulation Example 2 is mixed with the collected skin mites. This was diluted with water to obtain a sample of this example. This sample was sprayed on skin mites and the time until the death of skin mites was measured. Sample P is a 30-year-old man, Sample R is a 31-year-old woman, Sample S is a 34-year-old man, Sample T is a 25-year-old man, and Sample U is a 20-year-old woman. Table 4 lists the time to death of all skin mites. “Leave” is the time when the image is left as it is. The samples T and U were carried out without counting the number of collected skin mites.

  Further, this sample was impregnated into a tape and adhered to the skin of the specimens P to U described above. The state of sticking was continued for 12 hours, 24 hours, and 3 days, and the influence on the skin was examined. As a result, no skin diseases such as red spots and sores occurred in any specimen. As a result, the irritation to the skin is small and the safety is high. Therefore, even when used repeatedly, skin diseases such as rough skin are not induced.

Subject P in Embodiment 1, R, with respect to S, coated with a sample of Example 1 in 1 month the skin, were counted reduction of skin mites inhabiting the skin nasal groove portion after 1 month. As a result, the sample P decreased from 12 to 0, the sample R decreased from 8 to 1, and the sample S decreased from 13 to 0.

  The cosmetic cream of Formulation Example 1, the lotion of Formulation Example 2, and the shampoo of Formulation Example 3 were allowed to be continuously used by 3 specimens (subjects) for one month, and the number of skin mites before and after use was determined. I counted. A skin tick confirms the number of individuals in the skin by collecting sebum from the skin of the specimen. Sample V is a 36 year old male, Sample W is a 39 year old female, and Sample X is a 35 year old female. Table 5 shows this result, showing that there is no or a drastic decrease in skin mites after one month of use, and this is effective in controlling skin mites.

  Since the skin mite control agent of the present invention kills skin mites, it can prevent acne, rough skin, reduced skin metabolic function, and hair loss. Since the skin external preparation of the present invention contains a skin mite control agent, it can control skin mites in addition to the original effects of the external preparation.

Claims (1)

  It contains a mixture of cypress water, safflower extract, sea buckthorn oil, arnica extract, linden extract, cedar extract, hypericum extract, sage extract, yarrow extract, mallow extract, chamomile extract, and eucalyptus extract as active ingredients A skin mite control agent.