JP4561978B2 - Solid dialysis agent and method for producing the same - Google Patents

Description

  The present invention relates to a dialysis preparation for use in hemodialysis therapy for patients with renal failure, particularly a solid dialysis agent comprising an electrolyte component, a pH adjuster and / or glucose, and a method for producing the same.

  Dialysis fluids used in recent hemodialysis treatments have been replaced by bicarbonate dialysis fluids that are less burdensome to patients than conventional acetic acid dialysis fluids. However, in bicarbonate dialysate, bicarbonate ions react with calcium and magnesium ions to produce insoluble compounds (metal carbonates such as calcium carbonate and magnesium carbonate), so it is difficult to formulate as a single agent. .

Therefore, in general, electrolytes of sodium chloride, potassium chloride, calcium chloride, magnesium chloride, and sodium acetate, a concentrated solution “A agent” containing glucose and a pH adjusting agent added as necessary, and powdered A two-agent configuration of “B agent” made of sodium hydrogen carbonate is employed.
However, the “A agent” which is this concentrated liquid is usually filled with 5 to 15 L of concentrated liquid in a polyethylene container. From its size and weight, transportation cost, securing of storage space in the hospital, and use The later disposal method is a big problem.

  Therefore, in order to solve these problems, powdering (solidification) of the agent A itself has been proposed (Patent Document 1, Patent Document 2, Patent Document 3, etc.) and has already been commercialized. The manufacturing method of this currently commercially available solid dialysis agent is to mix each raw material component (powder), optionally add a binder liquid, granulate, dry, sizing, etc. Generally done. In many cases, a granulating apparatus for granulating each component and a drying apparatus for drying the granulated product are manufactured using different apparatuses. Therefore, when the granulated product is transferred to the drying apparatus after granulation, the granulated product is in a wet state, so that it becomes a large lump and requires a pulverization process, and the fine powder increases due to crushing. There is a fault to be terrible. Furthermore, when this large lump is dried, it is necessary to increase the amount of dry air in order to prevent agglomeration of the granulated material, and there is a disadvantage that the amount of fine powder increases due to drying with this large amount of air. there were.

  In such a solid dialysis agent with a lot of fine powder, there is a problem that dust is easily generated when the preparation is put into a dissolution apparatus, and the acetic acid odor used as a pH adjuster at that time is quite strong. It is also a cause of worsening the work environment in the medical field.

  In addition, dirt on the electrolyte component particles that are the core of the solid dialysis agent or dirt that may be caused by contamination in the solidification manufacturing process may adhere to the dissolution apparatus. For example, such a problem is particularly likely to occur in a method in which a solid electrolyte for dialysis described in Patent Document 2 is stirred and mixed, pulverized, and then granulated.

Furthermore, in powder dialysis preparations using acetic acid as a pH adjuster, problems such as an increase in glucose degradation products due to acetic acid have been observed, and studies have been conducted on the production of agent A using glucose as a separate agent.
On the other hand, Patent Document 3 discloses a multi-layer solid dialysate solidified in a tablet shape with a multi-layer structure. However, in such a method, dust is not scattered and handling is easy. It is complicated, expensive to manufacture, and the melting apparatus is different from the conventional one, which is not realistic.
Japanese Patent Publication No.57-88116 Japanese Patent Laid-Open No. 2-311418 Japanese Patent Laid-Open No. 6-237991

  Therefore, in view of the above situation, the present invention provides a solid dialysate comprising an electrolyte component, a pH adjuster and / or glucose in a dialysis preparation used for hemodialysis therapy for patients with renal failure. Sodium chloride, potassium chloride, calcium chloride, An object of the present invention is to provide a method for producing a solid dialysis agent having an electrolyte component composed of magnesium and sodium acetate, and a solid dialysis agent comprising a pH adjuster, which has good uniformity of content, excellent solubility, and high production efficiency. And

  In order to solve such problems, the present inventors have conducted intensive research. As a result, the electrolyte components used in dialysis preparations are deliquescent, and each of calcium chloride and magnesium chloride, which are minor components, is dissolved separately. The resulting aqueous solution is used as a binder liquid, and the electrolyte components excluding the remaining calcium chloride and magnesium chloride are divided into two parts, and the above binder liquid is added separately and mixed, granulated, and dried for each granulation step. After obtaining the product, it was found that a solid dialysis agent having excellent uniformity in content and good solubility can be obtained by simply mixing the granulated product.

  In addition, by using a granulated product that uses calcium chloride binder liquid and magnesium chloride binder liquid separately, it is possible to adjust the amount of water for each granulation and change the blending ratio of sodium acetate, etc., and optimize granulation conditions. As a result of intensive studies, it has been found that the granulation time can be greatly shortened and the solid dialysis agent can be continuously mass-produced, and the present invention has been completed.

Accordingly, the present invention provides the following aspects:
1. Among the electrolyte components of sodium chloride, potassium chloride, calcium chloride, magnesium chloride and sodium acetate in the method for producing a solid dialysis agent comprising an electrolyte component, a pH adjuster and / or glucose for preparing a bicarbonate dialysate The component excluding calcium chloride and magnesium chloride is divided into two parts, and a solution obtained by dissolving calcium chloride in water is added as a binder liquid to one of them, and the granulated product is obtained by a granulating step of mixing, granulating and drying (1) A solution obtained by dissolving magnesium chloride in water as a remaining component is added as a binder liquid, and a granulated product (2) is obtained by a granulating step of mixing, granulating, and drying, and then each obtained granulated product is obtained. A method for producing a solid dialysis agent, comprising mixing the products (1) and (2),
2. In the granulation step of the granulated product (1), the calcium chloride concentration in the binder liquid is 15 to 61% as the solid content, The method for producing a solid dialysis solvent according to 1 above,
3. In the granulation step of the granulated product (2), the magnesium chloride concentration in the binder liquid is 10 to 42% as the solid content, The method for producing a solid dialysis solvent according to 1 above,
4). The method for producing a granulated product (1) according to 1 above, wherein an aqueous calcium chloride solution as a binder liquid is added in an amount of 25 to 500 parts by weight as an amount of water to 100 parts by weight of sodium acetate,
5). The method for producing a granulated product (1) according to 4 above, wherein the calcium chloride concentration in the binder liquid is 15 to 61% as a solid content,
6). The method for producing a granulated product (2) according to 1 above, wherein 5 to 100 parts by weight of a magnesium chloride aqueous solution as a binder liquid is added as an amount of water to 100 parts by weight of sodium acetate,
7). The method for producing a solid granulated product (2) according to 6 above, wherein the magnesium chloride concentration in the binder liquid is 10 to 42% as a solid content,
8). The method for producing a solid dialysis solvent according to 1 above, comprising mixing the granulated product (1) and the granulated product (2) obtained by the production method of 4 to 7,
9. A solid dialysis solvent produced by the production method according to any one of 1, 2, 3 or 8 above,
It is.

  When the electrolyte component is granulated in the conventional method for producing a solid dialysis agent, all the electrolyte components are mixed together and granulated. In that case, calcium chloride and magnesium chloride An aqueous solution in which both were dissolved was added as a binder liquid. However, in the present invention, a binder liquid in which calcium chloride as a trace component is dissolved in water and a binder liquid in which magnesium chloride is dissolved in water are added. Each is individually used and has one feature in that it is added to the electrolyte component and mixed and granulated.

According to the present invention, it is possible to produce a solid dialysis agent having excellent content uniformity and good solubility. In addition, the production method of the present invention uses a conventional aqueous solution in which both calcium chloride and magnesium chloride are dissolved as a binder solution, and is added to the electrolyte components of sodium chloride, potassium chloride and sodium acetate, mixed and granulated. Compared with the method, granulation and drying time can be greatly shortened. Furthermore, in the particle size distribution of the obtained granulated product, there are few large agglomerates and fine powders, good mixing properties, high productivity for mass production, and significant cost reduction. Can be achieved.
Therefore, when the solid dialysis agent of the present invention is put into the dissolution apparatus, dust is not generated, and there is almost no acetic acid odor used as a pH adjuster. It has the advantage of maintaining a good environment.

  The agent for solid dialysis provided by the present invention is an agent comprising an electrolyte component and a pH adjuster, and if necessary, glucose is added to form agent A, and agent B comprising sodium bicarbonate is added at an appropriate concentration. After being diluted and mixed, it is used as a perfusate for hemodialysis.

  In the solid dialysis agent provided by the present invention, the essential electrolyte components are sodium chloride, potassium chloride, calcium chloride, magnesium chloride, and sodium acetate, but sodium citrate may be added instead of sodium acetate. it can. Further, other electrolyte components can be used without particular limitation as required. Moreover, as a pH adjuster, what is generally used, such as an acetic acid, lactic acid, hydrochloric acid, a citric acid, malic acid, may be sufficient, but an acetic acid and a citric acid are especially preferable. At that time, it is more preferable to use sodium acetate as an electrolyte component in the case of acetic acid and sodium citrate in the case of citric acid.

For example, the amount of each component in such an agent (the prescription amount of the preparation) is generally as follows.
Na ⁺ 130-145 mEq / L
K ⁺ 0-4 mEq / L
Ca ⁺⁺ 0-4 mEq / L
Mg ⁺⁺ 0-2 mEq / L
Cl ^- 55-135 mEq / L
HCO ₃ ^- 20~45 mEq / L
Acetate ion 0-20 mEq / L
(Or citrate ion 0-10 mEq / L)

That is, as a solid (powder) dialysis agent to be contained when dissolved in a certain amount of water, Na ⁺ : 90 to 140 mmol, K ⁺ : 0 to 4 mmol, Ca ⁺⁺ : 0.5 to 2. 2 mmol, Mg ⁺⁺ : 0.2 to 1.0 mmol, Cl ⁻ : 90 to 140 mmol, CH ₃ COO ⁻ : 6 to 15 mmol, glucose: 4 to 12 mmol are preferable.
Further, it is preferable to use a combination of 0 to 2.0 g / L as glucose and Na ⁺ : 15 to 40 mmol and HCO ₃ ⁻ : 15 to 40 mmol as sodium bicarbonate.

  In the present invention, calcium chloride and magnesium chloride, which are small amount electrolyte components and have deliquescence, are separately dissolved in water and used as a binder liquid. The amount of water used in preparing the binder solution is different because the solubility of calcium chloride and magnesium chloride in water is different. For example, when preparing a binder liquid in which calcium chloride is dissolved, the calcium chloride concentration is about 15 to 61% as a solid content, more preferably about 25 to 45%, still more preferably about 35 to 43%. It is good to be about. When preparing a binder solution in which magnesium chloride is dissolved, the magnesium chloride concentration is about 10 to 42%, more preferably about 15 to 36%, more preferably about 20 to 36% as a solid content. It is good to be about.

  When the moisture content of the binder is small, the adhesion and aggregation action of each particle is small and granulation is difficult to proceed. Granulation becomes difficult.

  In the production of the solid dialysis agent of the present invention, the binder solution prepared by dissolving calcium chloride and the binder solution dissolving magnesium chloride are separately used, and the electrolyte excluding the remaining calcium chloride and magnesium chloride. The ingredients are divided into two parts, and the above-mentioned binder liquids are added individually, and each granulated product (1) and (2) is produced by a granulating step of mixing, granulating and drying.

  In this case, the remaining electrolyte components other than calcium chloride and magnesium chloride do not necessarily need to be exactly divided into two, and can be divided into amounts suitable for addition, mixing and granulation of the binder liquid described later. it can. In some cases, glucose can also be added.

  The amount of each binder solution added can be adjusted according to the weight of sodium acetate contained in the electrolyte components excluding the remaining calcium chloride and magnesium chloride to optimize granulation. Specifically, for example, in the case of a binder solution of calcium chloride, 25 to 500 parts by weight, preferably 40 to 400 parts by weight, as the amount of water contained in the calcium chloride aqueous solution as the binder liquid with respect to 100 parts by weight of sodium acetate. Parts, more preferably 60 to 300 parts by weight. In the case of a magnesium chloride binder solution, the amount of water contained in the magnesium chloride aqueous solution as the binder solution is 5 to 100 parts by weight, preferably 10 to 60 parts by weight, more preferably 100 parts by weight of sodium acetate. It is preferable to add 20 to 40 parts by weight.

  The addition method of the binder liquid in the granulation step in the production of the solid dialysis agent provided by the present invention prevents the formation of coarse particles and makes the preparation excellent in the uniformity of the content, so that the binder liquid can be distributed evenly. For example, a method of spraying or dropping the powder on the stirring and mixing is preferable. Moreover, it is preferable to filter the binder liquid to add before addition from a viewpoint of the stain | pollution | contamination prevention to the melt | dissolution apparatus at the time of melt | dissolution of the obtained powder dialysate. In this way, separate granulated products (1) and (2) excellent in content uniformity are produced by using and adding deliquescent calcium chloride and magnesium chloride as binder solutions individually dissolved and added. The

  The apparatus used in such a granulation step may be a general mixing granulator that can uniformly mix and granulate using the components crushed above and a binder solution, such as a stirring and mixing granulator, a universal mixing machine. Machine, kneader, fluidized bed granulator, rolling granulator and the like, but are not limited to these apparatuses as long as they have equivalent performance.

Next, the obtained granulated product is dried. The drying apparatus used in this drying step may be a general batch type or continuous type, and examples thereof include a fluidized bed dryer and a vacuum dryer.
Thereafter, in order to adjust the dried granulated product to a desired size, it is preferable to perform granulation. The apparatus used here may be a general one, for example, a crushing type granulator, a classifier or the like.

In the present invention, the granulated product (1) obtained by using the binder solution prepared by dissolving calcium chloride prepared above and the granulated product (2) obtained by using the binder solution dissolving magnesium chloride. ) To prepare a target solid dialysis agent. This mixing can be performed by, for example, a W-type, V-type, ribbon-type mixer or the like.
In this mixing, the granulated product (1) and the granulated product (2) produced above may be mixed in an amount capable of containing a desired electrolyte component as a final solid dialysis agent. The granule (1) and the granulated product (2) are each produced by a large amount of batch production, and then have an advantage that they can be easily produced by mixing in a desired amount.

  In the solid preparation, the granulated product (1) and the granulated product (2) of the present invention, it contains approximately 80% or more of sodium chloride, and by appropriately adjusting the sodium chloride particle size, The granulated products (1) and (2) can be efficiently produced, and a uniform solid dialysis agent can be easily obtained by mixing them.

  In the present invention, when the pH adjuster is a liquid such as acetic acid, the mixture of the granulated product (1) and the granulated product (2) mixed as described above contains an electrolyte component using a mixing device. By adding the particles and the pH adjusting agent while mixing them and sucking the odor, the intense acetic acid odor when being put into the dissolving apparatus can be reduced. Further, when the pH adjuster is a liquid such as acetic acid, it is added to either the granulated product (1) or the granulated product (2) while mixing the pH adjuster using a mixing device, The other granulated product (2) or granulated product (1) can also be mixed. In addition, glucose may be added and mixed before or after the addition of the pH adjusting agent. In this case, a general mixing device may be used, and examples thereof include W type, V type, and ribbon type mixers. The suction is performed using, for example, a vacuum pump, a blower pump, or the like. The granulated product produced by the present invention is porous and absorbs these pH adjusters well.

  When the pH adjuster is a solid such as citric acid, it is added as a raw material in the mixing process, or as a binder liquid in the granulating process, or mixed with the granulated product before or after the granulating process. The pH adjusting agent can be added depending on the method used.

The container packaging material of the present invention is preferably one that prevents permeation of water vapor and gas. For example, it is desirable to use a material having a moisture permeability (40 ° C., 90% RH) of 1.0 g / cm ² · 24 hr or less. Examples of the material include PET / glass vapor-deposited PET / PE, PET / aluminum oxide / nylon, PET / SiOx / CPP, PET / SiOx / nylon / CPP, and OPP / SiOx / CPP.

  The present invention is described in detail below based on examples, but the present invention is not limited to these examples.

Example 1:
Sodium chloride, potassium chloride, and sodium acetate were added to a stirring granulator (FSGS-5J, manufactured by Fukae Pautech Co., Ltd.) with the composition shown in granulated product A in Table 1 to be described later, and mixed (agitator: 200 rpm; chopper: 1800 rpm) was performed for 5 minutes, and then the calcium chloride aqueous solution shown in granulated product A in Table 1 was added all at once, and wet granulation was performed for 10 minutes (up to 5 minutes agitator: 300 rpm; chopper: 3600 rpm, 5 minutes and after Is agitator: 100 rpm; chopper: no rotation). The obtained granulated material is dried using a fluidized bed granulator / dryer (FLO-5 type, manufactured by Freund Sangyo Co., Ltd.) at a supply air temperature of 60 ° C. until the moisture value becomes 0.5% or less. Granule A was obtained.

  Similarly, sodium chloride, potassium chloride and sodium acetate were mixed in the formulation shown in granulated product B in Table 1, and then wet granulated with an aqueous magnesium chloride solution shown in granulated product B in Table 1 (within 5 minutes; agitator : 300 rpm; Chopper: 3600 rpm), and drying was performed at a supply air temperature of 80 ° C. using a fluidized bed granulator / dryer (FLO-5 type, manufactured by Freund Corporation) to obtain a granulated product B.

As for the obtained two types of granulated products A and B, the granulation time was both as short as 10 minutes or less, and the particle size distribution of both granulated products was measured by a sieving method. There was almost no agglomerate of 7 mm or more, and the average particle diameter showed similar physical properties, indicating that a good granulated product was obtained.
These results are summarized in Table 2 below.

  Next, about these granulated products obtained above, using a granulated product A 1200g, granulated product B 800g, mixing for 30 minutes with a container type mixer (LM-10, manufactured by Kotobuki Industries Co., Ltd.), A mixture having good mixing properties was obtained. In the addition of acetic acid as a pH adjuster, 1.6% acetic acid was added in several portions to the amount of granulated material and mixed for 30 minutes to obtain a powdered acetic acid dialysis agent.

Example 2:
Sodium chloride, potassium chloride and sodium acetate were added to a stirring granulator (FSGS-5J, manufactured by Fukae Pautech Co., Ltd.) with the composition shown in the granulated product C in Table 1 to be described later, and mixed (agitator: 200 rpm; chopper: 1800 rpm) was performed for 5 minutes, and then the calcium chloride aqueous solution shown in granulated product C in Table 1 was added all at once, and wet granulation was performed for 5 minutes (agitator: 300 rpm; chopper: 3600 rpm). The obtained granulated material is dried using a fluidized bed granulator / dryer (FLO-5 type, manufactured by Freund Sangyo Co., Ltd.) at a supply air temperature of 60 ° C. until the moisture value becomes 0.5% or less. Granule C was obtained.

  Similarly, after mixing sodium chloride, potassium chloride and sodium acetate with the formulation shown in granulated product D in Table 1, wet granulation was performed for 5 minutes with an aqueous magnesium chloride solution shown in granulated product D in Table 1 (agitator: 300 rpm; chopper: 3600 rpm), and drying was carried out at a supply air temperature of 80 ° C. using a fluidized bed granulator / dryer (FLO-5 type, manufactured by Freund Sangyo Co., Ltd.).

  With respect to the obtained two types of granulated products C and D, by changing the addition ratio of sodium acetate, the granulation time was both as short as 5 minutes, and the particle size distribution of both granulated products was measured by a sieving method. As a result, both of the granulated materials had almost no aggregate of 1.7 mm or more, the average particle diameter showed similar physical properties, and good granulated materials were obtained (see Table 2).

  Next, for these granulated products obtained above, 1800 g of the granulated product A and 1200 g of the granulated product B were mixed for 30 minutes with a container-type mixer (LM-10, manufactured by Kotobuki Industries Co., Ltd.) A mixture having good mixing properties was obtained. In the addition of acetic acid as a pH adjuster, 1.6% acetic acid was added in several portions to the amount of granulated material and mixed for 30 minutes to obtain a powdered acetic acid dialysis agent.

Comparative Example 1:
Sodium chloride, potassium chloride, and sodium acetate were added to a stirring granulator (FSGS-5J, manufactured by Fukae Pautech Co., Ltd.) with the composition shown in the granulated product E in Table 1 described later, and mixed (agitator: 200 rpm; chopper: 1800 rpm) was performed for 5 minutes, and then the calcium chloride / magnesium chloride aqueous solution shown in granulated product E in Table 1 was added all at once, and wet granulation was performed for 6 minutes (agitator: 300 rpm; chopper: 3600 rpm). A lump of about 2 to 3 cm was observed in the granulated product. The obtained granulated material is dried using a fluidized bed granulator / dryer (FLO-5 type, manufactured by Freund Sangyo Co., Ltd.) at a supply air temperature of 60 ° C. until the moisture value becomes 0.5% or less. Granule E was obtained. As a result of measuring the particle size distribution of the obtained granulated product E by a sieving method, a mass of about 2 to 3 cm does not collapse by drying, and the proportion of aggregates of 1.7 mm or more is very 35.5%. Many (see Table 2).

Comparative Example 2:
Sodium chloride, potassium chloride, and sodium acetate were added to a stirring granulator (FSGS-5J, manufactured by Fukae Pautech Co., Ltd.) with the composition shown in the granulated product F in Table 1 to be described later, and mixed (agitator: 200 rpm; chopper: 1800 rpm) was performed for 5 minutes, and then the calcium chloride / magnesium chloride aqueous solution shown in granulated product F in Table 1 was added all at once, and wet granulation was performed for 65 minutes (up to 5 minutes agitator: 300 rpm; chopper: 3600 rpm, After 5 minutes, agitator: 100 rpm; no chopper rotation). Sampling was performed at about 300 g after 25 and 45 minutes during granulation, and using a fluidized bed granulator / dryer (FLO-1 type, manufactured by Freund Sangyo Co., Ltd.), the moisture value was 0.5 at an air supply temperature of 60 ° C. It was made to dry until it became less than% (25 minute granulated material: F1, 45 minute granulated material: F2). The granulated product after 65 minutes is dried using a fluidized bed granulator / dryer (FLO-5 type, manufactured by Freund Sangyo Co., Ltd.) at an air supply temperature of 60 ° C. until the moisture value becomes 0.5% or less. A granulated product F3 was obtained, and the particle size distribution of the obtained granulated product was measured by a sieving method. Although the agglomerates of about 2 to 3 cm are greatly reduced by the gentle granulation conditions after 5 minutes and the granulation time, the proportion of agglomerates of 1.7 mm or more is 4% for 65 minutes granulation. (See Table 2).

  Tables 1 and 2 collectively show the formulations of the granulated products of the above-described Examples and Comparative Examples and their evaluations.

単位：ｇ

Unit: g

From the above results, when an aqueous solution in which both calcium chloride and magnesium chloride are dissolved is added as a binder liquid, it is necessary to lengthen the granulation time in order to prepare a good granulated product with few aggregates. there were.
On the other hand, when the calcium chloride aqueous solution and the magnesium chloride aqueous solution of the present invention are separated as binder solutions, respectively, and the granulation step is performed separately, it becomes possible to adjust the addition ratio of sodium acetate, and a comparative example Compared with, the granulation time was significantly shortened. From this, it was suggested that the method of the present invention is high in productivity, and a granulated product with good mixing property without agglomerates was obtained.

  As described above, in the production of the solid dialysis agent according to the present invention, calcium chloride and magnesium chloride are used for granulation of sodium chloride, potassium chloride, calcium chloride, magnesium chloride and sodium acetate which are electrolyte components by the wet granulation method. Calcium chloride aqueous solution and magnesium chloride aqueous solution are separately used as binder liquid to the mixed powder of electrolyte components excluding, and added and mixed in batches, granulated and dried, and then mixed the obtained granulated products In addition, by adding and mixing acetic acid as a pH adjuster, a solid dialysis agent excellent in content uniformity can be produced.

  The production method of the present invention is a conventional method in which an aqueous solution in which both calcium chloride and magnesium chloride are dissolved is used as a binder liquid, added to the electrolyte components of sodium chloride, potassium chloride and sodium acetate, mixed and granulated. In comparison, granulation and drying time can be greatly shortened.

  Further, the produced granulated product has a large particle size distribution and a small amount of agglomerates and fine powders, and has a good mixing property. Therefore, the solid dialysis agent of the present invention is put into a dissolution apparatus. At this time, dust is not generated, and there is almost no acetic acid odor used as a pH adjuster, and there is an advantage that the working environment in the medical field can be maintained well.

Further, in the mass production, the productivity is high, the mass production can be performed in a short time, and the cost can be greatly reduced. Therefore, the medical contribution is great.

Claims (9)

  Among the electrolyte components of sodium chloride, potassium chloride, calcium chloride, magnesium chloride and sodium acetate in the method for producing a solid dialysis agent comprising an electrolyte component, a pH adjuster and / or glucose for preparing a bicarbonate dialysate The component excluding calcium chloride and magnesium chloride is divided into two parts, and a solution obtained by dissolving calcium chloride in water is added as a binder liquid to one of them, and the granulated product is obtained by a granulating step of mixing, granulating and drying (1) A solution obtained by dissolving magnesium chloride in water as a remaining component is added as a binder solution, and a granulated product (2) is obtained by a granulating step of mixing, granulating, and drying, and then each obtained granulated product is obtained. A method for producing a solid dialysis agent, comprising mixing the products (1) and (2).   The method for producing a solid dialysis solvent according to claim 1, wherein in the granulation step of the granulated product (1), the calcium chloride concentration in the binder liquid is 15 to 61% as the solid content.   The method for producing a solid dialysis solvent according to claim 1, wherein in the granulation step of the granulated product (2), the magnesium chloride concentration in the binder liquid is 10 to 42% as the solid content.   The method for producing a granulated product (1) according to claim 1, wherein 25 to 500 parts by weight of a calcium chloride aqueous solution as a binder liquid is added as an amount of water to 100 parts by weight of sodium acetate.   The method for producing a granulated product (1) according to claim 4, wherein the calcium chloride concentration in the binder liquid is 15 to 61% as a solid content.   The method for producing a granulated product (2) according to claim 1, wherein 5 to 100 parts by weight of a magnesium chloride aqueous solution as a binder liquid is added as an amount of water to 100 parts by weight of sodium acetate.   The method for producing a solid granulated product (2) according to claim 6, wherein the magnesium chloride concentration in the binder liquid is 10 to 42% as a solid content.   The method for producing a solid dialysis solvent according to claim 1, wherein the granulated product (1) and the granulated product (2) obtained by the production method of claims 4 to 7 are mixed. A solid dialysis solvent produced by the production method according to claim 1.