JP4594724B2 - Oil-in-water emulsion composition - Google Patents

Description

  The present invention relates to an oil-in-water emulsion composition that can be stably formulated with various oils and is useful for a wide range of cosmetics.

  Oil-in-water emulsified compositions are widely used in the fields of cosmetics, pharmaceuticals and the like because of their good feeling. However, an emulsion system formed with an oil agent, a surfactant and water does not have sufficient stability. In particular, it is important to stably emulsify since there are many crystalline hardly soluble substances among the components that exhibit various physiological effects on the skin.

  In order to solve this problem, conventionally, means such as reducing the blending amount of the crystalline component and increasing the amount of the surfactant have been adopted. However, if the amount of the hardly soluble substance is decreased, the action of the oil component cannot be obtained sufficiently, and if the amount of the surfactant is increased, there is a problem that irritation to the skin occurs, which is an essential solution. Not.

On the other hand, Patent Document 1 discloses a polysaccharide derivative having a thickening action that is higher in the temperature range than room temperature and higher than that at room temperature, and a stabilizing action of a hydrophobic substance in water, and a toiletry product containing the polysaccharide derivative. Patent Document 2 describes an oil-in-water emulsion in which a stable emulsified form is maintained even in a system in which a surfactant is present in a large amount by the polysaccharide derivative and the aqueous polyol solution. There has been no report of a method for stabilizing unstable systems containing substances.
WO 00/73351 JP 2003-226612 A

  Accordingly, an object of the present invention is to provide an oil-in-water emulsion composition in which a hardly soluble substance can be stably blended, its emulsification system is stable, and the skin feel is good.

  Therefore, the present inventor has studied to stably blend a poorly soluble substance. As a result, the polysaccharide derivatives and polyols described in Patent Documents 1 and 2 conventionally known as water-soluble thickeners and nonionic ions of HLB 4-9 are known. If the surfactant is used in combination with an oil agent, the emulsified particles can be made finer and more uniformly dispersed than before, and even if the oil agent contains a crystalline oily component, it is stable and feels to the skin. It was found that an oil-in-water emulsified composition that is good and can be widely used in the fields of cosmetics, pharmaceuticals and the like can be obtained.

That is, the present invention includes the following components (A), (B), (C), (D), (E) and (F):
(A) Some or all of the hydrogen atoms of the hydroxy group of the polysaccharide or derivative thereof are the following groups (a)
(A) a group represented by the following general formula (1) [the hydrogen atom of the hydroxy group of the substituent (a) may be further substituted with a substituent (a)]

[Wherein E ¹ represents a linear or branched divalent saturated hydrocarbon group having 1 to 6 carbon atoms which may be substituted by a hydroxy group or an oxo group, and n represents a number of 8 to 300. , N A ¹ are the same or different and each represents a linear or branched divalent saturated hydrocarbon group having 1 to 6 carbon atoms, and E ² represents an ether bond or an oxycarbonyl group (—OCO— or —COO -), R represents a linear or branched alkyl group having 4 to 30 carbon atoms which may be substituted by a hydroxy group. ]
Polysaccharide derivatives substituted with
(B) polyols,
(C) a nonionic surfactant of HLB 4-9,
(D) a hardly soluble substance,
(E) An oil agent for dissolving the component (D) (F) An oil-in-water emulsion composition containing water is provided.

  The oil-in-water emulsified composition of the present invention contains a poorly soluble substance stably and has a good feel when applied to the skin.

E ¹ in the general formula (1) of (a) of the polysaccharide (A) is preferably one having 2 or 3 carbon atoms, specifically ethylene, propylene, trimethylene, 2-hydroxytrimethylene, 1-hydroxymethyl. Ethylene, 1-oxoethylene, 1-oxotrimethylene, 1-methyl-2-oxoethylene and the like are preferable.

As A ¹ in the general formula (1), those having 2 or 3 carbon atoms are preferable, and specifically, ethylene, propylene and trimethylene are preferable. The degree of polymerization of (—OA ¹ —) represented by n is preferably 8 to 120, particularly 10 to 60 from the viewpoint of thickening effect and emulsion stability, and n A ¹ may be the same or different. Here, n means the average number of moles added. E ² is an ether bond or an oxycarbonyl group, and an ether bond is preferred.

  As R in the general formula (1), a linear or branched alkyl group having 5 to 25 carbon atoms, particularly 6 to 20 carbon atoms is preferable, and a linear alkyl group is preferable from the viewpoint of stability. Specifically, octyl group, decyl group, dodecyl group, tetradecyl group, hexadecyl group, octadecyl group, isostearyl group and the like are preferable.

  The degree of substitution by the substituent (a) in the polysaccharide derivative (A) is preferably 0.0001 to 1, more preferably 0.0005 to 0.5, and particularly preferably 0.001 to 0.1 per constituent monosaccharide residue.

  In addition to the above substituent (a), the polysaccharide derivative (A) may be further substituted with one or more groups selected from the following substituents (b), (c) and (d). Moreover, the hydrogen atom of the hydroxy group of substituent (a)-(d) may be further substituted by substituent (a)-(d).

(B) a C1-C5 sulfoalkyl group which may be substituted by a hydroxy group or a salt thereof As the substituent (b), a 2-sulfoethyl group, a 3-sulfopropyl group, a 3-sulfo-2-hydroxy Examples thereof include a propyl group and a 2-sulfo-1- (hydroxymethyl) ethyl group. Among them, a 3-sulfo-2-hydroxypropyl group is preferable from the viewpoint of stability and production. All or part of these substituents (b) may be salts with group 1 or group 2 elements such as Na, K, Ca and Mg, amines, and organic cations such as ammonium. The degree of substitution with these substituents (b) is preferably in the range of 0 to 1, more preferably 0 to 0.8, especially 0 to 0.5 per constituent monosaccharide residue.

(C) a carboxyalkyl group having 2 to 6 carbon atoms which may be substituted by a hydroxy group or a salt thereof As the substituent (c), carboxymethyl group, carboxyethyl group, carboxypropyl group, carboxybutyl group, carboxypentyl A carboxymethyl group is preferred from the standpoint of stability and production. All or part of these substituents (c) may be salts with group 1 or group 2 elements such as Na, K, Ca and Mg, and organic cations such as amine and ammonium. The degree of substitution by these substituents (c) is preferably in the range of 0 to 1, more preferably 0 to 0.8, especially 0 to 0.5 per constituent monosaccharide residue.

  (D) Group represented by the following general formula (2)

[Wherein D ¹ represents a linear or branched divalent saturated hydrocarbon group having 1 to 6 carbon atoms which may be substituted by a hydroxy group, and R ¹ , R ² and R ³ are the same or different. And a C 1-3 linear or branched alkyl group which may be substituted by a hydroxy group, and X ⁻ represents a hydroxy ion, a halogen ion or an organic acid ion. ]

As D ¹ in the cationic substituent (d), ^one having 2 or 3 carbon atoms is preferable, and specifically, ethylene, propylene, trimethylene, 2-hydroxytrimethylene, 1-hydroxymethylethylene and the like are preferable.

Examples of R ¹ , R ² and R ³ in the cationic substituent (d) include a methyl group, an ethyl group, a propyl group, and a 2-hydroxyethyl group, and among them, a methyl group and an ethyl group are preferable.

The halogen ion represented by X ⁻ in the cationic substituent (d) is a chlorine ion, bromine ion, iodine ion or the like, and the organic acid ion is CH ₃ COO ⁻ , CH ₃ CH ₂ COO ⁻ , CH ₃ ( CH ₂ ) ₂ COO _2- ^{and the} like. X ⁻ is preferably a hydroxy ion, a chlorine ion or a bromine ion.

  The degree of substitution with these cationic substituents (d) is preferably in the range of 0 to 0.5, particularly 0 to 0.3 per constituent monosaccharide residue.

  The polysaccharide derivative of component (A) used in the present invention is preferably a polymer compound having a molecular weight of 10,000 to 10,000,000, more preferably 10,000 to 2,000,000, particularly 30,000 to 1,500,000. Specific examples of the water-soluble polymer include a hydrophobic polysaccharide having a group represented by the formula (1) and a group represented by the formula (1) of 0.0001 to 0.1, preferably 0, based on the main chain monomer. A water-soluble polysaccharide derivative having a molecular weight of 10,000 to 2,000,000, preferably 30,000 to 1,500,000 is added at a ratio of 0.001 to 0.05.

  Examples of the polysaccharide to which the group of formula (1) is bonded include polysaccharides such as cellulose, guar gum, starch, pullulan, dextran, fructan, mannan, agar, carrageenan, chitin, chitosan, pectin, alginic acid, and hyaluronic acid. These include derivatives substituted with a methyl group, an ethyl group, a hydroxyethyl group, a hydroxypropyl group, or the like. These substituents can be substituted singly or in combinations of constituent monosaccharide residues. Examples of polysaccharide derivatives include hydroxyethyl cellulose, hydroxyethyl ethyl cellulose, hydroxyethyl guar gum, hydroxyethyl starch, methyl cellulose, methyl guar gum, methyl starch, ethyl cellulose, ethyl guar gum, ethyl starch, hydroxypropyl cellulose, hydroxypropyl guar gum, hydroxypropyl Examples include starch, hydroxyethyl methylcellulose, hydroxyethyl methyl guar gum, hydroxyethyl methyl starch, hydroxypropyl methyl cellulose, hydroxypropyl methyl guar gum, hydroxypropyl methyl starch and the like. Among these polysaccharides or derivatives thereof, cellulose, starch, hydroxyethyl cellulose, methyl cellulose, ethyl cellulose, and hydroxypropyl cellulose are preferable, and hydroxyethyl cellulose is particularly preferable. The weight average molecular weight of these polysaccharides or derivatives thereof is preferably 10,000 to 10,000,000, more preferably 10 to 5,000,000, and particularly preferably 200,000 to 2,000,000.

  The polysaccharide derivative (A) used in the present invention is exemplified by the following general formula when the case of using celluloses as the polysaccharide or its derivative is taken as an example.

[Wherein, R ⁴ , R ⁵ and R ⁶ are the same or different, and (1): a hydrogen atom, a methyl group, an ethyl group, a hydroxyethyl group, a hydroxypropyl group, etc. (2): a polyoxyalkylene group A substituent, (3): a sulfoalkyl group, (4): a carboxyalkyl group, (5): a group selected from cationic substituents, Q being the same or different, an alkylene group having 2 to 4 carbon atoms P, q and r are the same or different and represent a number of 0 to 10. QO group, R ⁴ group, R ⁵ group, R ⁶ group, p, q and r may be the same or different within a repeating unit or between repeating units. ]

  In the oil-in-water emulsion composition of the present invention, the water-soluble polymer of component (A) is 0.001 to 10% by mass, and further 0% from the viewpoint of emulsification stability, viscosity, and feel when applied to the skin. It is preferable to contain 0.01 to 5 mass%, especially 0.1 to 2 mass%.

  The polyols of the component (B) are polyhydric alcohols having two or more hydroxyl groups in the molecule, specifically, ethylene glycol, propylene glycol, 1,3-butylene glycol, 1,4-butylene glycol, etc. Polyalkylene glycols such as dipropylene glycol; sugar alcohols such as glucose, maltose, maltose, sucrose, fructose, xylitol, sorbitol, erythritol, maltotriose, and threitol; glycerin, polyglycerin, and amylolytic reduced alcohol 1 type or 2 types or more of these are used.

  Component (B) is 0.01 to 30% by mass, more preferably 0.5 to 20% by mass, in the oil-in-water emulsion composition of the present invention, in terms of emulsification stability, viscosity, and feel when applied to the skin. %, Particularly 1 to 10% by mass is preferable.

  The component (C) HLB 4 to 9 nonionic surfactant is important for stably emulsifying the oil in the oil-in-water emulsion composition of the present invention. When a nonionic surfactant having an HLB of less than 4 is used, the non-ionic surfactant having an HLB of 4 or more in order to maintain sufficient stability of the oil phase when a crystalline component is contained in the oil. It is preferable to add an ionic surfactant, and it is preferable to add a nonionic surfactant having an HLB of 9 or less in order to stabilize the emulsion system.

Here, the HLB value is
HLB = 7 + (logMw / logMo) Mw: Molecular weight of hydrophilic group, Mo: Molecular weight of lipophilic group. A preferable HLB is 5 to 9, and 6 to 9 is more preferable.

  Examples of the nonionic surfactant having 4 to 9 HLB include polyoxyethylene sorbitan fatty acid ester, sorbitan fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene hydrogenated castor oil, polyoxyethylene glycerin fatty acid ester, glycerin fatty acid ester , Alkyl glyceryl ether, alkyl polyglucoside and the like. Among these, sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene hydrogenated castor oil, and alkyl glyceryl ether are more preferable.

  These nonionic surfactants are 0.001 to 10% by mass, more preferably 0.01 to 5% by mass, especially 0 to 0% by mass in the oil-in-water emulsion composition from the viewpoint of emulsion stability and oil phase stability. It is preferable to contain 1-1.1 mass%.

  The poorly soluble substance of component (D) has a solubility at 25 ° C. when isopropyl palmitate is used as a solvent of 10% by mass or less of the composition comprising component (D) and isopropyl palmitate, and a melting point of 30 ° C. The above is said. The solubility is preferably 0.00001 to 10% by mass, more preferably 0.0001 to 10% by mass, and the melting point is preferably 40 to 200 ° C. These hardly soluble substances include 4-tert-butyl-4′-methoxybenzoylmethane, 2,4,6-tris [4- (2-ethylhexyloxy) anilino] -1,3,5-triazine, dimethoxybenzylidene. Ceramide Type 1 to 7 (for example, J. Lipid Res., 24: 759 (for example, amidated UV absorbers such as dioxoimidazolidinepropionate-2-ethylhexyl), sphingosine, dihydrosphingosine, phytosphingosine or sphingadienin. 1983) and natural ceramides such as porcine and human ceramides described in FIG. 4 of J. Lipid. Res., 35: 2069 (1994)) and ceramides such as cetyl PG hydroxyethyl palmitamide Analogues, camphene, menthol, α-terpineol, β-terpineol, γ-terpineol, dihydroterpineol, 4-tu Nord, 3 Tsuyanoru, alpha over fenchyl alcohol, borneol β over caryophyllene alcohol, perfume ingredients, such as cedrol.

  The oil agent of component (E) is not particularly limited as long as its solubility is 10% by mass or more of the composition comprising components (D) and (E) at 50 ° C. and used in the fields of cosmetics, pharmaceuticals and the like. However, higher alcohols, sterols, silicones, fluorine-based oils, other oily components, and the like can be mentioned.

  Examples of the higher alcohols include benzyl alcohol, isocetyl alcohol, isostearyl alcohol, behenyl alcohol, hexadecyl alcohol, phenylethyl alcohol, cetanol, stearyl alcohol, oleyl alcohol, 2-octyldodecanol, batyl alcohol, and 2-hexyldecanol. In particular, cetanol and stearyl alcohol are preferable.

Examples of the sterols include cholesterol, cholesteryl isostearate, provitamin D ₃ , campesterol, stegmasteranol, stigmasterol, 5-dihydrocholesterol, α-spinasterol, parisosterol, cryonasterol, γ-sitosterol, stigmasterenol. , Salgasterol, apenasterol, ergostanol, sitosterol, corvisterol, chondirasterol, polyferasterol, halicronasterol, neosbongosterol, fucostosterol, aptostanol, ergostadanol, ergosterol, 22-dihydroergosterol , Brassicasterol, 24-methylenecholesterol, 5-dihydroergosterol, dehydroergosterol , Fungisterol, Cholestanol, Coprostanol, Dimostosterol, 7-Hetcholesterol, Latosterol, 22-Dehydrocholesterol, β-Sitosterol, Cholestatrien-3β-ol, Coprostanol, Cholestanol, Ergosterol, 7-Dehydro Cholesterol, 24-dehydrocholestaglandin-3β-ol, echilenin, echrin, estrone, 17β-estradiol, androst-4-en-3β, 17β-diol, dehydroshrimp androsterone, cholesterol alkenyl succinate No. 294989). Of these, cholesterol, cholesteryl isostearate, and cholesteryl alkenyl succinate are particularly preferable.

  Examples of the silicones are those usually blended in toiletry products, such as octamethylpolysiloxane, tetradecamethylpolysiloxane, methylpolysiloxane, highly polymerized methylpolysiloxane, methylphenylpolysiloxane, octamethylcyclotetrasiloxane, Methyl polycyclosiloxane such as decamethylcyclopentasiloxane, trimethylsiloxysilicic acid, further alkyl-modified silicone, polyether-alkyl-modified silicone, amino-modified silicone, fluorine-modified silicone, alkylglyceryl ether-modified silicone, JP-A-6-72851 And modified silicones such as modified organopolysiloxanes described in the above publication.

  As the fluorinated oil, perfluoropolyether and fluorine-modified silicone, which are perfluoro organic compounds that are liquid at room temperature, are preferable. For example, perfluorodecalin, perfluoroadamantane, perfluorobutyltetrahydrofuran, perfluorooctane, perfluoro Nonane, perfluoropentane, perfluorodecane, perfluorododecane, perfluoropolyether, fluorine-containing ether compound represented by the following general formula (3)

(In the formula, Rf represents a linear or branched perfluoro group having 1 to 20 carbon atoms, R ¹ represents a linear or branched cycloalkyl group having 3 to 9 carbon atoms, and n represents a number of 1 to 8. And the like. Specific examples include 1,3-dimethylbutyl {2- (perfluorooctyl) ethyl} represented by the following formula (4).

  The other oily components may be volatile or non-volatile, for example, hydrocarbons such as solid or liquid paraffin, petrolatum, crystal oil, ceresin, ozokerite, montan wax, squalane, squalene; eucalyptus oil, Peppermint oil, camellia oil, macadamia nut oil, avocado oil, beef tallow, lard, horse tallow, egg yolk oil, olive oil, carnauba wax, lanolin, jojoba oil; glycerin monostearate, glyceryl distearate, glycerin monooleate, palmiticin Isopropyl, isopropyl stearate, butyl stearate, isopropyl myristate, neopentyl glycol dicaprate, diethyl phthalate, myristyl lactate, diisopropyl adipate, cetyl myristate, lactic acid Listyl, diisopropyl adipate, cetyl myristate, cetyl lactate, 1-isostearoyl-3-myristoylglycerol, cetyl 2-ethylhexanoate, 2-ethylhexyl palmitate, myristate-2-octyldodecyl, di-2-ethyl Ester oils such as neopentyl glycol hexanoate, oleic acid-2-octyldodecyl, glycerol triisostearate, di-paramethoxycinnamic acid-glyceryl mono-2-ethylhexanoate; higher grades such as stearic acid, palmitic acid, oleic acid, etc. Fatty acids; and natural essential oils such as rosemary, rooibos, royal jelly, and hamelis, lignans, vitamin E, oil-soluble vitamin C, vitamin A derivatives, and the like.

  The oil agent of component (E) is preferably contained in the oil-in-water emulsion composition of the present invention in an amount of 0.01 to 30% by mass, further 0.05 to 20% by mass, particularly 0.5 to 10% by mass.

  Even if the hardly soluble substance of component (D) is contained in the oil agent (E) in an amount of 0.01 to 30% by mass, further 0.05 to 20% by mass, particularly 0.1 to 15% by mass, Slightly soluble substances can be stably held in oil droplets.

  The water of the component (F) in the composition of the present invention is preferably 50 to 90% by mass, more preferably 70 to 90% by mass in the oil-in-water emulsion composition of the present invention.

  In the method for producing the oil-in-water emulsion composition of the present invention, the component (C) is added to and mixed with a solution or dispersion of some of the components (F), components (A) and (B), It is preferable to manufacture by diluting with the component (F). Furthermore, after adding and mixing components (C), (D), and (E) in a solution or dispersion of (1) component (F), a component (A) and (B), the remaining components A method of diluting with (F); and (2) adding component (C) to a solution in which a part of component (F), components (A), (B), (D) and (E) are dissolved or dispersed, It is more preferable to manufacture by the method of diluting with the remaining component (F) after mixing.

  The weight ratio of the composition obtained by adding and mixing the component (C) to the solution or dispersion containing the component (F), the components (A) and (B) and the remaining component (F) is 1/99. It is preferably in the range of ˜99 / 1, more preferably 1/99 to 65/35, particularly 1/99 to 50/50.

  The particle size of the oil droplets in the obtained emulsion composition of the present invention is preferably 10 μm or less, more preferably 0.1 to 10 μm, and particularly preferably 0.1 to 5 μm. When such fine particle oil droplets are formed, the stability is particularly good. Here, the particle diameter of the oil droplets can be measured by a laser diffraction / scattering particle size distribution analyzer (for example, HORIBA LA-910).

  The emulsified composition of the present invention is stable even if it contains a hardly soluble substance in the oil droplets, and can sufficiently exert the action and pharmacological action of the hardly soluble substance on the skin. Moreover, the form of a composition can also be made into mist form, a lotion, an emulsion, a cream, a bath agent, etc.

Examples 1-4 and Comparative Examples 1-5
Components (A), (B) and a part of water (1/4) are dispersed at 30 to 60 ° C., and components (C), (D) and (E) dissolved at 30 to 80 ° C. are added thereto. Then, after mixing at 30 to 60 ° C. for 30 to 60 minutes, it was diluted with the remaining water (3/4) to produce an oil-in-water emulsion composition (shown as Process I in FIG. 1).

Examples 5 and 6 and Comparative Example 6
Components (A), (B), (D), (E) and a part (1/4) of water are uniformly dispersed at 30 to 80 ° C., and then component (C) is added thereto and 30 to 60 ° C. For 30 to 60 minutes, and then diluted with the remaining water (3/4) to obtain an oil-in-water emulsion composition (shown as production method II in FIG. 1).

  The particle size of the oil droplets of the obtained emulsion composition was measured with a laser diffraction / scattering particle size distribution analyzer (HORIBA LA-910). Moreover, it was left to stand at 25 degreeC for 7 days, and the external appearance of the emulsion was observed. The results are shown in Table 1.

  As is clear from Table 1, the composition of the present invention containing components (A), (B), (C), (D), (E) and (F) is an emulsification system that stably holds an oil agent. On the other hand, when HLB does not contain the nonionic surfactant in the range of 4-9, the hardly soluble substance in an oil agent precipitates or an emulsification system isolate | separates.

It is a figure which shows the manufacturing method I and the manufacturing method II.

Claims (5)

The following components (A), (B), (C), (D), (E) and (F):
(A) Some or all of the hydrogen atoms of the hydroxy group of the polysaccharide or derivative thereof are the following groups (a)
(A) a group represented by the following general formula (1) [the hydrogen atom of the hydroxy group of the substituent (a) may be further substituted with a substituent (a)]

[Wherein E ¹ represents a linear or branched divalent saturated hydrocarbon group having 1 to 6 carbon atoms which may be substituted by a hydroxy group or an oxo group, and n represents a number of 10 to 60. , N A ¹ represents an ethylene group, E ² represents an ether bond or an oxycarbonyl group (—OCO— or —COO—), and R represents a carbon number of 4 to 30 which may be substituted by a hydroxy group. A linear or branched alkyl group is shown. ]
Polysaccharide derivatives substituted with
(B) a polyhydric alcohol having two or more hydroxyl groups in the molecule,
(C) 0.1 to 1% by mass of a nonionic surfactant of HLB 4 to 9,
(D) 0.01-30 % by mass of a compound selected from cedrol, 4-tert-butyl-4′-methoxybenzoylmethane and cetylpropyleneglycolhydroxyethylpalmitamide, based on component (E),
(E) Ester oil 0.01-30 mass%
(F) An oil-in-water emulsion composition containing water. Claim 1 Symbol placement of the oil-in-water emulsion composition content of 0.5 to 10 mass% of component (E). In the component (A), some or all of the hydrogen atoms of the hydroxy group of the polysaccharide derivative are further substituted with the following groups (b), (c) and (d):
(B) a sulfoalkyl group having 1 to 5 carbon atoms which may be substituted by a hydroxy group or a salt thereof (c) a carboxyalkyl group having 2 to 6 carbon atoms which may be substituted by a hydroxy group or a salt thereof (d) ) Group represented by the following general formula (2)

[Wherein D ¹ represents a linear or branched divalent saturated hydrocarbon group having 1 to 6 carbon atoms which may be substituted by a hydroxy group, and R ¹ , R ² and R ³ are the same or different. And a C 1-3 linear or branched alkyl group which may be substituted by a hydroxy group, and X ⁻ represents a hydroxy ion, a halogen ion or an organic acid ion. ]
A polysaccharide derivative substituted with one or more groups selected from [the hydrogen atom of the hydroxy group of these groups may be further substituted with a group (a), (b), (c) or (d)] The oil-in-water emulsion composition according to claim 1 or 2 . Claims obtained by adding and mixing component (C) into a solution or dispersion of some component (F), components (A) and (B), and then diluting with the remaining component (F). any one oil-in-water emulsion composition according 1-3. (1) After adding and mixing the components (C), (D), and (E) in a solution or dispersion of some of the components (F) and (A) and (B), the remaining components (F ) Or (2) Component (C) was added to and mixed with a solution in which some of component (F), components (A), (B), (D) and (E) were dissolved or dispersed. 4. The oil-in-water emulsion composition according to any one of claims 1 to 3 , obtained by a method of diluting with the remaining component (F).

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