JP4598359B2 - Liquid injection device - Google Patents

Description

[0001]
BACKGROUND OF THE INVENTION
  The present invention relates to a liquid injection device.
[0002]
[Prior art]
  A prefilled syringe in which a chemical solution or the like is previously stored is known. The prefilled syringe includes an outer cylinder having a discharge port at the tip, a gasket inserted into the outer cylinder, and a plunger (pushing element) connected to the gasket, and is surrounded by the outer cylinder and the gasket. The chemical solution is stored in the space.
[0003]
  Further, in order to keep the chemical solution from leaking out from the discharge port and to maintain the sterility of the chemical solution, a film for liquid-tightly sealing the discharge port is attached to the discharge port.
[0004]
  In such a prefilled syringe, when a drug solution in an outer cylinder is administered to a patient, first, a film that seals the discharge port is peeled off, and then an injection needle equipped with a needle body is attached to the distal end portion of the outer cylinder. . In this state, the needle body is punctured into the patient's blood vessel, and the plunger is pressed toward the distal end of the outer cylinder to inject the drug solution into the blood vessel.
[0005]
  However, since the above operation is performed in the atmosphere, there is a risk that the chemical solution may be contaminated with bacteria or the like after the film is peeled off, or foreign substances may be mixed in the chemical solution. This operation is complicated. is there.
[0006]
[Problems to be solved by the invention]
  An object of the present invention is to provide a liquid injection device capable of preventing contamination by foreign substances and bacteria with a simple configuration, and further a liquid injection device capable of completing preparations for injecting a liquid such as a chemical solution by a simple operation. Is to provide.
[0007]
[Means for Solving the Problems]
  Such purposes are as follows (1) to (8This is achieved by the present invention.
[0008]
  (1) an outer cylinder having a liquid storage space inside;
  A liquid introduction part that protrudes from an end of the outer cylinder and has a flow path communicating with the liquid storage space inside;
  A valve mechanism that is installed on the outer periphery of the liquid introduction part and opens and closes the flow path;
  An operation member that operates the valve mechanism by rotating around the axis of the liquid introduction part;
  The valve mechanism is composed of a cylindrical inner plug installed between the outer periphery of the liquid introduction part and the operation member,The inner plug is configured to maintain liquid tightness between the liquid introduction portion and the operation member,
  The inner plug has a liquid introduction path that communicates with the flow path and opens the flow path, and an engagement portion that engages with the liquid introduction section and prevents separation from the liquid introduction section. ,
  The inner plug rotates with the rotation of the operation member, and a first position where the flow path and the liquid introduction path are blocked, and a second position where the flow path and the liquid introduction path communicate with each other. When the inner plug is in the second position, the liquid introduction path and the liquid storage space communicate with each other through the flow path,
  When the operation member is rotated 90 ° clockwise or counterclockwise from the state where the inner plug is in the first position,The operation member and the inner plug do not move in the axial direction of the liquid introduction part,The liquid injection device, wherein the inner plug is configured to be displaced to the second position.
[0013]
  (2The end of the channel opposite to the liquid storage space forms a side hole that opens to the side surface of the liquid introduction unit.(1)The liquid injection device as described.
[0014]
  (3(1) The above (having a marker indicating the position of the liquid introduction path and / or the side hole)2) Liquid injection device.
[0015]
  (4(1) to (1) having a lock means for defining a rotation position of the operation member with respect to the liquid introduction portion.3) The liquid injection device according to any one of the above.
[0016]
  (5The lock means has a function of positioning the operation member at least at the first position and the second position.4) Liquid injection device.
[0017]
  (6The operation member holds the needle tube at the tip thereof (1) to (1)5) The liquid injection device according to any one of the above.
[0018]
  (7The operation member is also a hub of the needle tube (6) Liquid injection device.
[0019]
  (8(1) to (1), wherein the liquid injection device is a prefilled syringe.7) The liquid injection device according to any one of the above.
[0020]
DETAILED DESCRIPTION OF THE INVENTION
  Hereinafter, the liquid injection device of the present invention will be described in detail based on a preferred embodiment shown in the accompanying drawings. In the following description, a liquid injection device in which liquid is stored in advance will be described as a representative. In addition, the needle tip side in the figure is the distal end, and the plunger side is the proximal end.
[0021]
  FIG. 1 is a partial cross-sectional view of the liquid injection device of the present invention, FIG. 2 is a longitudinal cross-sectional view showing the configuration of the tip of the liquid injection device of the present invention (the state where the inner plug is in the flow path blocking position), FIG. 2 is a sectional view taken along line AA in FIG. 2, FIG. 4 is a sectional view taken along line BB in FIG. 2, and FIG. 5 is a configuration of the tip of the liquid injection device of the present invention. 6 is a cross-sectional view taken along the line CC in FIG. 5, and FIG. 7 is a cross-sectional view taken along the line DD in FIG. In the following description, the upper side in FIGS. 1, 2, and 5 is referred to as a “base end”, and the lower side is referred to as a “tip”.
[0022]
  A liquid injection device 1 shown in FIG. 1 includes a liquid injection device main body (prefilled syringe) 2, an inner plug 7 installed at the tip of the liquid injection device main body 2, and the liquid injection device main body via the inner plug 7. 2 is provided. Hereinafter, the configuration of each unit will be described.
[0023]
  The liquid injection device main body 2 includes an outer cylinder (syringe outer cylinder) 3, a liquid guide part 4 formed to project from the tip of the outer cylinder 3, a gasket 5 that can slide in a liquid-tight manner in the outer cylinder, and a gasket 5 and a plunger (presser) 6 for moving the gasket 5 within the outer cylinder 3.
[0024]
  The outer cylinder 3 is composed of a bottomed cylindrical member having a bottom 31, and a liquid storage space 33 is formed in a portion surrounded by a gasket 5 described later.
[0025]
  The liquid Q is stored in the liquid storage space 33. Examples of the liquid Q to be stored include sugar injection solutions such as glucose, electrolyte correction injection solutions such as sodium chloride and potassium lactate, vitamin agents, vaccines, antibiotic injection solutions, contrast agents, steroid agents, and proteolytic enzymes. Examples include inhibitors, fat emulsions, anticancer agents, anesthetics, stimulants, narcotics, distilled water, disinfectants, liquid foods, alcohol, and the like.
[0026]
  A plate-like flange 32 is provided on the outer periphery of the base end of the outer cylinder 3. When the plunger 6 is moved and operated relative to the outer cylinder 3, the operation can be performed by putting a finger on the flange 32. The flange 32 may be integrally formed on the outer periphery of the proximal end of the outer cylinder 3, or the flange 32 and the outer cylinder 3 may be separately manufactured and joined.
[0027]
  As a constituent material of each of the outer cylinder 3 and the plunger 6 described later, for example, cyclic polyolefin (for example, ethylene and tetracyclo [4.4.0.1^2.5. 1^7.10] -3-dodecene copolymer, etc.), polyvinyl chloride, polyethylene, polypropylene, polystyrene, poly- (4-methylpentene-1), polycarbonate, acrylic resin, acrylonitrile-butadiene-styrene copolymer, polyethylene terephthalate, etc. And various resins such as polyester, butadiene-styrene copolymer, polyamide (for example, nylon 6, nylon 6,6, nylon 6,10, nylon 12), polyethersulfone, and polysulfone. Among these, cyclic polyolefins (for example, ethylene and tetracyclo [4.4.0.1] are easy to mold.^2.5 . 1^7.10] -3-dodecene copolymer, etc.), polypropylene, poly- (4-methylpentene-1), polyethersulfone, and polysulfone are preferred.
[0028]
  In addition, it is preferable that the constituent material of the outer cylinder 3 is substantially transparent in order to ensure internal visibility.
[0029]
  In addition, a liquid introduction part 4 that is reduced in diameter from the body part of the outer cylinder 3 and protrudes toward the distal end is integrally formed at the center of the bottom 31 at the distal end of the outer cylinder 3.
[0030]
  The liquid introduction part 4 has a substantially cylindrical shape, and a flow path 41 communicating with the liquid storage space 33 is formed therein. An end portion of the flow path 41 opposite to the liquid storage space 33 forms a pair of side holes 42 opened on the side surface of the liquid introduction portion 4. These side holes 42 are provided on the substantially opposite side (at intervals of 180 °) via the axis of the liquid introduction part 4.
[0031]
  In addition, a ring-shaped concave portion 43 that is recessed inward is formed on the outer periphery of the tip portion of the liquid introduction portion 4. An engaging portion 72 of the inner plug 7 described later is engaged with the recess 43.
  On the outer periphery (periphery) of the liquid guiding part 4, a later-described inner plug 7 is attached (installed).
[0032]
  A gasket 5 made of an elastic material is accommodated in the outer cylinder 3. The gasket 5 has a hollow portion 51, and a head portion 63 of a plunger 6 described later is fitted into the hollow portion 51.
[0033]
  The gasket 5 can be slid in the axial direction (longitudinal direction) of the outer cylinder 3 either on the proximal end side or on the distal end side by operating the plunger 6.
[0034]
  A ring-shaped protrusion 52 may be formed on the outer peripheral portion of the gasket 5 along the axial direction thereof. By sliding the projecting portion 52 in close contact with the inner peripheral surface 34 of the outer cylinder 3, the liquid tightness is more reliably maintained and the slidability is improved. In addition, the formation position and the number of the protrusions 52 are not particularly limited.
[0035]
  The constituent material of the gasket 5 is not particularly limited. For example, various rubber materials such as natural rubber, butyl rubber, isoprene rubber, butadiene rubber, styrene-butadiene rubber, silicone rubber, polyurethane, polyester, polyamide, Examples thereof include elastic materials such as various thermoplastic elastomers such as olefins and styrenes, or mixtures thereof.
[0036]
  The gasket 5 only needs to have at least an outer peripheral portion made of the elastic material as described above. For example, the gasket 5 has a core portion (not shown) made of a resin material. The thing of the structure by which the elastic material is arrange | positioned so that it may cover may be used.
[0037]
  The gasket 5 has an outer periphery, for example, polytetrafluoroethylene or a copolymer thereof, ethylene-tetrafluoroethylene copolymer, tetrafluoroethylene, PVDF (polyvinylidene fluoride), PCTFE (polychlorotrifluoro). You may coat | cover with the film comprised with fluororesins, such as ethylene), TFE (tetrafluoroethylene), and FEP (fluorinated ethylene propylene). Thereby, the slidability with respect to the internal peripheral surface 34 of the outer cylinder 3 of the gasket 5 improves.
[0038]
  A plunger 6 that moves the gasket 5 in the axial direction within the outer cylinder 3 is connected to the gasket 5.
[0039]
  In FIG. 1, the plunger 6 is constituted by a plate piece having a cross-shaped cross section, and a plate member 61 is integrally formed on the tip side thereof. A plate-like flange 62 is provided at the base end of the plunger 6. The plunger 6 is operated by putting the flange 62 on a finger or the like. The flange 62 may be formed integrally with the proximal end portion of the plunger 6, or the flange 62 and the plunger 6 may be separately manufactured and joined.
[0040]
  In addition, a mushroom-like head portion (connecting portion) 63 that is inserted and fitted into the hollow portion 51 of the gasket 5 is formed at the distal end portion of the plunger 6.
[0041]
  On the outer periphery of the liquid introduction part 4, a substantially cylindrical inner plug 7 is installed so as to be rotatable relative to the liquid introduction part 4 about the axis of the liquid introduction part 4.
[0042]
  The inner plug 7 constitutes a valve mechanism having a function of opening and closing the flow path 41 of the liquid introduction unit 4.
  The inner plug 7 is formed with a liquid introduction path 71 that communicates with the flow path 41 of the liquid introduction section 4 and opens the flow path 41. The liquid introduction path 71 is formed in the middle of the side portion of the inner plug 7 and extends to the tip of the inner plug 7 along the axial direction.
[0043]
  The inner plug 7 is in the first position where the flow path 41 and the liquid introduction path 71 are blocked, that is, the position shown in FIG. 2 (hereinafter, the position of the inner plug 7 is referred to as “flow path blocking position”). Then, each side hole 42 is liquid-tightly sealed. As a result, the liquid Q stored in the liquid storage space 33 only stops filling the flow path 41 and is prevented from leaking out of the liquid injection instrument body 2.
[0044]
  On the other hand, the inner plug 7 has a second position at which the flow path 41 and the liquid introduction path 71 communicate with each other, that is, the position shown in FIG. ), The liquid introduction path 71 communicates with the liquid storage space 33 via the flow path 41, and the liquid Q stored in the liquid storage space 33 can be discharged to the outside of the liquid injection instrument body 2. .
[0045]
  A ring-shaped engagement portion 72 that protrudes inward is formed on the inner periphery of the distal end portion of the inner plug 7. When the engaging portion 72 is engaged with the concave portion 43 of the liquid guiding portion 4, the inner plug 7 is more reliably prevented from being detached (detached) from the liquid guiding portion 4.
[0046]
  Further, a ring-shaped protrusion 73 protruding outward is formed on the outer periphery of the tip end portion of the inner plug 7. The protrusion 73 engages with a recess 112 of the hub 11 described later.
[0047]
  As a constituent material of such an inner plug 7, when the inner peripheral surface of the inner plug 7 is in close contact with the outer peripheral surface of the liquid guiding portion 4 and the inner plug 7 is in the flow path blocking position, each side hole 42 is liquid-filled. Any material can be used as long as it can be tightly sealed. For example, HDPE (high density polyethylene), LDPE (low density polyethylene), PP (polypropylene), PE (polyethylene), etc. Similar ones can be used.
[0048]
  A hub 11 provided in a later-described injection needle 10 is attached to the outer periphery of the inner plug 7. That is, the inner plug 7 is installed between the liquid introduction part 4 and the hub 11.
[0049]
  The injection needle 10 has a hub 11 and a needle tube 12 fixed (held) to the distal end portion of the hub 11.
[0050]
  The hub 11 is formed of a substantially cylindrical member, and the inner plug 7 is inserted into the inner cavity portion 111 thereof, and the inner peripheral surface of the hub 11 and the outer peripheral surface of the inner plug 7 are in close contact with each other. 7 is liquid-tightly fitted.
[0051]
  For this reason, for example, in a state where the liquid injection device main body 2 is held and fixed by a hand or the like, the hub is held by the other hand or the like, and the hub 11 is rotated clockwise (or counterclockwise around the axis of the liquid introduction part 4 When rotating clockwise, the inner plug 7 rotates in the same direction around the axis of the liquid introduction part 4 as the hub 11 rotates. As a result, the inner plug 7 is displaced between the flow path blocking position (first position) and the flow path communication position (second position).
[0052]
  In other words, the hub 11 also functions as an operation member that operates the inner plug (valve mechanism) 7 by rotating around the axis of the liquid introduction part 4.
[0053]
  Further, the hub 11 is formed with a concave portion 112 that engages with the protrusion 73 of the inner plug 7 by being recessed in a ring shape toward the outside on the inner periphery of the distal end portion of the hub 11. By engaging the recess 112 and the protrusion 73, the hub 11 is securely (liquid-tightly) attached by the inner plug 7. Therefore, the hub 11 (injection needle 10) is more reliably prevented from being detached (detached) from the inner plug 7.
[0054]
  The hub 11 may be bonded (attached) to the inner plug 7 only by a fitting force. For example, the hub 11 may be fused (heat fusion, high frequency fusion, ultrasonic fusion, etc.), or by an adhesive. It may be fixed (fixed) by a method such as adhesion.
[0055]
  The hub 11 is preferably made of a transparent (colorless and transparent), colored transparent or translucent resin, and the internal visibility is ensured. Thereby, the liquid introduction part 71 of the inner stopper 7 can be visually recognized from the outside.
[0056]
  The constituent material of the hub 11 is not particularly limited. Polyolefin such as polyethylene, polypropylene, polybutadiene, and ethylene-vinyl acetate copolymer, polyvinyl chloride, polyurethane, polystyrene, polymethyl methacrylate, polycarbonate, polyamide, and polyethylene. Examples thereof include various resin materials such as polyesters such as terephthalate and polybutylene terephthalate, acrylic resins, ABS resins, AS resins, ionomers, polyacetals, polyphenylene sulfides, and polyether ether ketones.
[0057]
  A hollow needle tube 12 is fixed (fixed) to the tip of the hub, and the lumen 121 of the needle tube 12 communicates with the lumen 111 of the hub 11.
[0058]
  The needle tube 12 is made of, for example, a metal material such as stainless steel, aluminum or an aluminum alloy, titanium or a titanium alloy. A sharp needle tip 122 is formed at the tip of the needle tube 12. The shape of the needle tip 122 is not particularly limited, and may be a shape having a blade surface inclined at a predetermined angle with respect to the axis of the needle tube 12 as shown in the figure.
[0059]
  Examples of a method for fixing (fixing) the needle tube 12 to the hub include a method such as fitting, caulking, fusing, adhesion using an adhesive, or a method using these in combination.
[0060]
  Moreover, the cap P that encloses the needle tip 12 may be attached to the distal end side of the hub 11 in the liquid injection device 1 when not in use. The cap P has a function of preventing danger and preventing contamination of the needle tube 12.
[0061]
  As the constituent material of the cap P, for example, the same constituent materials as those described for the outer cylinder 3 and the plunger 6 can be used.
[0062]
  Such a liquid injection device 1 may be provided with a lock means 8 that defines the rotational position of the hub (operation member) 11 with respect to the liquid introduction part 4.
[0063]
  In the present embodiment, as the hub 11 is rotated about the axis of the liquid introduction unit 4, the inner plug 7 rotates about the axis of the liquid introduction unit 4 integrally (or in conjunction). It is configured. Therefore, if the rotation position of the inner plug 7 with respect to the liquid introduction part 4 is defined, the rotation position of the hub 11 with respect to the liquid introduction part 4 is also defined. Therefore, the locking means 8 in the present embodiment is configured to define the rotational position of the inner plug 7 with respect to the liquid introduction part 4.
[0064]
  Below, the locking means 8 is demonstrated based on FIG. 4 and FIG.
  The inner plug 7 has a mountain-shaped convex portion 81 formed on the inner periphery of the base end portion so as to protrude inward. In the cross-sectional shape of the mountain-shaped convex portion 81, the top portion 811 forms an angle of less than 180 ° (in the present embodiment, a substantially right angle).
[0065]
  On the other hand, on the outer periphery of the base end portion of the liquid introduction portion 4, a total of three valley-shaped recesses, which are a pair of valley-shaped recesses 82 and a valley-shaped recess 83 provided therebetween, are in the shape of the mountain-shaped protrusions 81. Correspondingly formed. The pair of valley-shaped recesses 82 is installed on the substantially opposite side via the axis of the liquid introduction part 4 corresponding to the side holes 42, respectively, and the valley-shaped recess 83 is substantially in the middle of the pair of valley-shaped recesses 82, that is, It is installed at a position that makes approximately 90 ° with each valley-shaped recess 82.
  The mountain-shaped convex portion 81 and the valley-shaped concave portions 82 and 83 constitute the locking means 8.
[0066]
  In addition, a small-diameter portion 84 having an outer diameter set to a small diameter by a predetermined length is formed at a base end portion of the liquid introduction portion 4 at a portion between the valley-shaped concave portion 83 and the adjacent valley-shaped concave portion 82. Has been. Thereby, a gap is formed between the outer surface 841 of the small diameter portion 84 and the inner peripheral surface of the proximal end portion of the inner plug 7. The width of the gap (the length in the radial direction in FIGS. 4 and 7) is set to be shorter than the height of the mountain-shaped convex portion 81.
[0067]
  When the inner plug 7 is in the flow path blocking position (see FIG. 4), the mountain-shaped convex portion 81 is engaged with the valley-shaped concave portion 83, and the position thereof is defined (positioned). From this state, when the liquid injection device main body 2 is grasped by hand and, for example, the hub 11 is rotated approximately 90 ° counterclockwise in FIG. Rotates about 90 ° in the same direction around the axis of the liquid introduction part 4, reaches the flow path communication position (see FIG. 7), and the mountain-like convex part 81 engages with the valley-like concave part 82. As described above, when the inner plug 7 is in the flow path communication position, the side surface 812 of the mountain-shaped convex portion 81 comes into contact with the upper side surface 821 of the valley-shaped concave portion 82, so that the inner plug 7 is centered on the axis of the liquid introduction portion 4. Is prevented (restricted) from rotating in the same direction. That is, the inner plug 7 is defined (positioned) at the flow path communication position.
[0068]
  From the state where the inner plug 7 is in the flow path blocking position, the liquid injection device main body 2 is grasped by hand, and the hub 11 is rotated approximately 90 ° clockwise around the axis of the liquid introduction part 4 in FIG. In this way, the inner plug 7 can be set to the flow path communication position.
[0069]
  Further, such a liquid injection device 1 may have the marker 9 indicating the position of the liquid introduction path 71 of the inner plug 7 and the side holes 42 of the liquid introduction part 4.
[0070]
  In the figure, the marker 9 has a groove 91 formed at a position corresponding to the liquid guide path 71 on the outer periphery of the base end of the inner plug 6, and each side hole on the outer periphery of the distal end of the outer cylinder 3 (outer periphery near the bottom 31). And a pair of grooves 92 formed at positions corresponding to 42.
[0071]
  Thereby, for example, even when it is difficult to visually recognize the inside of the liquid injection device 1 (the flow path 41, the liquid introduction path 71, etc.), when the groove 91 coincides with one of the grooves 92 ( 5), it can be seen that the inner plug 7 is in the flow passage communication position, and when the groove 91 does not coincide with any of the grooves 92 and is separated from each groove 92 by approximately 90 ° (see FIG. 5). In FIG. 2), it can be seen that the inner plug 7 is in the flow path blocking position. For this reason, it is convenient (advantageous) when operating the liquid injection device 1.
[0072]
  Further, it is preferable that the groove 91 is provided substantially coincident with the position of the blade surface formed in the needle tip 122 of the needle tube 12. In this case, the groove 91 can also indicate the position of the blade surface. Accordingly, when the needle tube 12 is punctured into the blood vessel of the patient, for example, the operation is performed by using the liquid injection device 1 with the groove 91 positioned upward and the blade surface of the needle tube 12 facing upward. Can be performed more reliably.
[0073]
  The marker 9 is not limited to the one having the illustrated configuration, and may indicate only one of the liquid introduction path 71 and the side hole 42.
[0074]
  Further, the outer periphery of the outer end of the outer cylinder 3 (the outer periphery in the vicinity of the bottom 31) includes a position perpendicular to each side hole 42, that is, a position that can indicate that the inner plug 7 is in the flow path blocking position. Three grooves may be provided.
[0075]
  Further, the marker 9 may be formed by, for example, a protrusion, printing, a textured slit, or the like instead of the groove (the groove 91 and the groove 92).
[0076]
  Furthermore, it is preferable that at least the inside of such a liquid injection device 1 is subjected to sterilization such as high-pressure steam sterilization, gas sterilization, or radiation sterilization in advance.
[0077]
  Moreover, in such a liquid injection device 1, the inside plug 7 fitted to both the liquid introduction part 4 and the hub 11 is provided, and the liquid introduction path 71 and the flow path 41 of the inside plug 7 are communicated with each other. Since the channel 41 is opened, when the liquid Q is discharged from the liquid storage space 33, the amount of the liquid Q remaining in the liquid Q can be extremely small (for example, about 7 to 10 μL). . Therefore, particularly when an expensive chemical solution is stored as the liquid Q in the liquid storage space 33, there is an advantage that the chemical solution can be effectively used.
[0078]
  Moreover, since an existing product can be used as the injection needle 10, it is advantageous for reducing the manufacturing cost of the liquid injection device 1.
[0079]
  Next, an example of a method for using the liquid injection device 1 of the present invention will be described. In the following description, a case where the liquid Q is injected into the blood vessel of the patient will be described.
[0080]
  [1] First, the liquid injection device 1 stored in a packaging material (not shown) is taken out by opening the packaging material. In this state, the inner plug 7 is located at the flow path blocking position (first position) where the flow path 41 and the liquid introduction path 71 are blocked (see FIGS. 2 to 4). Thereby, the inner plug 7 liquid-tightly seals each side hole 42 and prevents the liquid Q in the liquid storage space 33 and the flow path 41 from leaking out of the liquid injection device body 2.
[0081]
  At this time, since the groove 91 and each groove 92 do not coincide with each other, it can be easily recognized that the inner plug 7 is in the flow path blocking position.
[0082]
  [2] Next, the outer cylinder 3 of the liquid injection device body 2 is gripped and fixed by hand, the hub 11 of the injection needle 10 is gripped by the other hand, and the hub 11 is centered on the axis of the liquid introduction part 4. 3 and 4, the inner plug 7 rotates in the same direction as the hub 11 around the axis of the liquid introduction part 4 as the hub 11 rotates. At this time, the top part 811 of the mountain-shaped convex part 81 gets over the shoulder part 842 of the small diameter part 84 (refer FIG. 3 and FIG. 4). Thereby, the mountain-shaped convex portion 81 is detached from the valley-shaped concave portion 83, and the engagement between the mountain-shaped convex portion 81 and the valley-shaped concave portion 83 is released.
[0083]
  [3] Further, when the hub 11 is rotated counterclockwise in FIG. 3 and FIG. 4 about the axis of the liquid introduction part 4, the inner plug 7 also has the same direction about the axis of the liquid introduction part 4. Rotate to. At this time, the top portion 811 of the mountain-shaped convex portion 81 moves in the same direction along the outer surface 841 while being in sliding contact with the outer surface 841 of the small diameter portion 84. For this reason, a rotational load acts on the hand of the operator who rotates the hub 11.
[0084]
  Next, when the top portion 811 passes through the shoulder portion 843 of the small diameter portion 84, the mountain-shaped convex portion 81 enters the valley-shaped concave portion 82 and engages with the valley-shaped concave portion 82. As a result, the inner plug 7 becomes a flow path communication position (second position), and the flow path 41 and the liquid guide path 71 communicate with each other.
[0085]
  At this time, the rotational load is reduced at once, and the change of the load is transmitted to the hand of the operator who rotates the hub 11 (so-called click feeling is obtained), so that the inner plug 7 is connected to the flow passage position. Can be easily confirmed.
[0086]
  Furthermore, at this time, since the groove 91 of the inner plug 7 and the groove 92 of the outer cylinder 3 coincide with each other, it can be recognized that the inner plug 7 has reached the flow path communication position.
[0087]
  From this state, even if the hub 11 is rotated counterclockwise in FIG. 7 about the axis of the liquid introduction portion 4, the side surface 812 of the mountain-shaped convex portion 81 and the upper side surface 821 of the valley-shaped concave portion 82 are Therefore, the inner plug 7 is prevented (restricted) from rotating counterclockwise in FIG. 7 about the axis of the liquid introduction part 4. Therefore, the hub 11 is prevented from rotating counterclockwise in FIG. 7 around the axis of the liquid introduction part 4. That is, the hub 11 is desirably locked at the flow path blocking position.
[0088]
  [4] Next, the cap P is removed from the liquid injection device 1. Thereby, the preparation for injecting the liquid Q in the liquid injection device 1 into the blood vessel of the patient is completed.
[0089]
  [5] Thereafter, the needle tube 12 of the liquid injection device 1 is punctured into the blood vessel of the patient. Thereby, the inside of the patient's blood vessel and the inside of the liquid storage space 33 communicate with each other via the flow path 41, the liquid introduction part 71, the lumen 121 of the needle tube 12, and the like.
[0090]
  [6] When the flange 62 of the plunger 6 is pressed toward the distal end direction with a finger or the like from the state of the step [5], the gasket 5 moves in the distal end direction and the volume of the liquid injection space 33 decreases. Thereby, the liquid Q sequentially passes through the flow path 41, the liquid guide path 71, the space at the tip of the lumen 111 of the hub 11, and the lumen 121 of the needle tube 12, and is administered (injected) into the blood vessel of the patient. The
[0091]
  In such a liquid injection device 1, (1) the hub 11 is operated to rotate the inner plug 7 with respect to the axis of the liquid introduction part 4, and the flow path 41 and the liquid introduction path 71 are communicated with each other. ) The preparation of injecting the liquid Q stored in the liquid injection device 1 into the blood vessel of the patient can be completed only by performing the two-stage operation of removing the cap P immediately before puncturing the patient's blood vessel. Since it is possible, it is excellent in operability. Moreover, in such a liquid injection device 1, since it is not necessary to connect the injection needle 10 to the liquid injection device main body in the atmosphere, foreign matter is mixed into the liquid Q, or the liquid Q is contaminated by bacteria or the like. Can be prevented more reliably.
[0092]
  In the liquid injection device 1 of the present embodiment, even when the hub 11 is rotated in the clockwise direction in FIGS. 3 and 4 about the axis of the liquid introduction part 4, the same effect as described above is produced.
[0093]
  As mentioned above, although the liquid injection device of this invention was demonstrated about embodiment of illustration, this invention is not limited to this, Each part which comprises a liquid injection device is arbitrary structures which can exhibit the same function. Can be substituted.
[0094]
  In addition, the liquid injection device of the present invention can be used not only for injecting liquid into a blood vessel of a patient, but also, for example, a liquid that needs to be adjusted for use in, for example, an infusion bag or bottle. Can also be used.
[0095]
  Moreover, in the liquid injection device of this invention, as what is accommodated in liquid storage space, it is not limited to a liquid, For example, a solid substance (a semi-solid substance is included) may be sufficient. In this case, the volume of the liquid storage space is increased by moving the plunger toward the proximal end in a state where the inner plug is in the flow path communication position. As a result, a liquid (for example, infusion solution) that can dissolve (or disperse) the solid substance in the liquid storage space is sucked once, and after the solid substance is dissolved (or dispersed), the liquid is injected (discharged). You just have to do it.
[0096]
  In the liquid injection device of the present invention, the side hole of the flow path only needs to be provided in at least one place on the side surface of the liquid introduction part. When only one side hole is provided, it is only necessary that the valley-shaped concave portion constituting the locking means, the groove functioning as the marker, and the like are formed at only one location.
[0097]
【The invention's effect】
  As described above, according to the present invention, since the valve mechanism can be opened and closed from the outside, contamination by foreign substances or bacteria can be prevented in preparation operations for injecting a liquid such as a chemical solution. Furthermore, the preparation can be completed with a simple operation.
[0098]
  Further, when the lock means is provided, it becomes easy to set the open / close state of the valve mechanism.
  Moreover, when a marker is provided, it becomes easy to confirm the open / closed state of the valve mechanism.
[Brief description of the drawings]
FIG. 1 is a partial cross-sectional view of a liquid injection device of the present invention.
FIG. 2 is a longitudinal sectional view showing the configuration of the tip of the liquid injection device of the present invention (in the state where the inner plug is at the flow path blocking position).
FIG. 3 is a cross-sectional view taken along line AA in FIG.
4 is a sectional view taken along line BB in FIG. 2. FIG.
FIG. 5 is a longitudinal sectional view showing the configuration of the tip of the liquid injection device of the present invention (in the state where the inner plug is at the flow channel communication position).
6 is a cross-sectional view taken along line CC in FIG.
7 is a cross-sectional view taken along the line DD in FIG.
[Explanation of symbols]
  1 Liquid injection device
  2 Liquid injection device body
  3 outer cylinder
  4 Liquid introduction part
  5 Gasket
  6 Plunger
  7 Inside plug
  8 Locking means
  9 Markers
  10 Injection needle
  11 Hub
  12 Needle tube
  P cap
  Q liquid

Claims (8)

An outer cylinder having a liquid storage space therein;
A liquid introduction part that protrudes from an end of the outer cylinder and has a flow path communicating with the liquid storage space inside;
A valve mechanism that is installed on the outer periphery of the liquid introduction part and opens and closes the flow path;
An operation member that operates the valve mechanism by rotating around the axis of the liquid introduction part;
The valve mechanism is configured by a cylindrical inner plug installed between the outer periphery of the liquid introduction part and the operation member, and the liquid stopper between the liquid introduction part and the operation member is formed by the inner plug. Is configured to preserve
The inner plug has a liquid introduction path that communicates with the flow path and opens the flow path, and an engagement portion that engages with the liquid introduction section and prevents separation from the liquid introduction section. ,
The inner plug rotates with the rotation of the operation member, and a first position where the flow path and the liquid introduction path are blocked, and a second position where the flow path and the liquid introduction path communicate with each other. When the inner plug is in the second position, the liquid introduction path and the liquid storage space communicate with each other through the flow path,
When the operation member is rotated 90 ° clockwise or counterclockwise from the state where the inner plug is in the first position, the operation member and the inner plug move in the axial direction of the liquid introduction part. The liquid injection device is configured such that the inner plug is displaced to the second position without being .   2. The liquid injection device according to claim 1, wherein an end portion of the flow path opposite to the liquid storage space forms a side hole that opens to a side surface of the liquid introduction portion.   The liquid injection device according to claim 2, further comprising a marker indicating a position of the liquid introduction path and / or the side hole.   The liquid injection device according to claim 1, further comprising a lock unit that defines a rotation position of the operation member with respect to the liquid introduction unit.   The liquid injection device according to claim 4, wherein the lock means has a function of positioning the operation member at least in the first position and the second position.   The liquid injection device according to claim 1, wherein the operation member holds a needle tube at a tip portion thereof.   The liquid injection device according to claim 6, wherein the operation member also serves as a hub of the needle tube.   The liquid injection device according to any one of claims 1 to 7, wherein the liquid injection device is a prefilled syringe.

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