JP4637447B2

JP4637447B2 - Heat-producing sympathetic nerve activator and composition containing the same

Info

Publication number: JP4637447B2
Application number: JP2002281453A
Authority: JP
Inventors: 信三谷; 豊太田; 寿之福田
Original assignee: Pola Chemical Industries Inc
Current assignee: Pola Orbis Holdings Inc
Priority date: 2002-09-26
Filing date: 2002-09-26
Publication date: 2011-02-23
Anticipated expiration: 2022-09-26
Also published as: JP2004115440A

Description

【０００１】
【発明の属する技術分野】
本発明は、熱産生交感神経活性化剤及びそれを含有する経口投与用の組成物に関する。
【０００２】
【従来の技術】
栄養状態が改善されすぎた現代に於いて、肥満は大きな社会問題となっている。これを反映して、日本に於いては「ダイエット」と言う言葉は、食事制限による摂取カロリーの低減を直接的に意味するようになっている。又、所謂健康食品に於いても、「ダイエット」を訴求したものが少なくない。この様な「ダイエット」を訴求した健康食品は、大きく分けると、１）グルコマンナンの如く非消化性繊維或いはそれの作るゲル化物を投与し、物理的に食物が消化器に入らないように抑制する、（特開平６−１８１７０２号）２）カプサイシン乃至はキンギンカ等の様に熱産生タンパク質（Ｕｎｃｏｕｐｌｉｎg Ｐｒｏｔｅｉｎ；ＵＣＰ）の発現を促進し、脂質の熱エネルギーへの変換を高め、脂質の蓄積を抑制する（特開２０００−１８９１０８号）、の２種が存在する。しかしながら、熱産生を司る、熱産生交感神経を活性化させる方法は知られていない。更に、ウコギ科のタラノキ属植物及びスイレン科乃至はハス科のハス属植物のエキスと生体に於ける熱産生の関係も全く知られていない。又、複合的な脂質蓄積システムに於いて、過剰な脂質の蓄積を抑制するためには、単一のメカニズムのみならず、複合的なメカニズムでの対応が必要であり、その意味で新しい脂質蓄積抑制のメカニズムの解明と脂質蓄積抑制素材の開発が望まれていた。
【０００３】
一方、ウコギ科（Ａｒａｌｉａｃｅａｅ）のタラノキ属植物（Ａｒａｌｉａ）が、民間薬として、発汗、解熱、鎮痛薬とし、頭痛、歯痛、リウマチ、神経痛に用いられること、及び、スイレン科（Ｎｙｍｐｈａｃａｃｃａｃ）乃至はハス科（Ｎｅｌｕｍｂｏｎａｃｅａｅ）のハス属植物（Ｎｅｌｕｍｂｏ）が収斂作用、鎮静作用、軽度の滋養作用を目的に民間薬として使用されることも知られていたが、これらのエキスが、熱産生交感神経活性化作用を有することは全く知られていなかったし、熱産生交感神経活性化を目的に経口的に投与されることも行われていなかった。
【０００４】
【発明が解決しようとする課題】
本発明は、この様な状況下為されたものであり、新しい脂質蓄積抑制のメカニズムに基づいた脂質蓄積抑制素材を提供することを課題とする。
【０００５】
【課題を解決するための手段】
本発明者らは、この様な状況に鑑みて、新しい脂質蓄積抑制のメカニズムに基づいた脂質蓄積抑制素材を求めて、鋭意研究努力を重ねた結果、ウコギ科（Ａｒａｌｉａｃｅａｅ）タラノキ属植物（Ａｒａｌｉａ）のウド（Ａｒａｌｉａｃｏｒｄａｔａ）のエキスが熱産生交感神経を活性化させる作用を有しており、かかる作用により、脂質蓄積を抑制できることを見出し、発明を完成させるに至った。即ち、本発明は、以下に示す技術に関するものである。
（１）ウド（Ａｒａｌｉａｃｏｒｄａｔａ）のエキスを含有することを特徴とする、熱産生交感神経活性化用の経口投与用の組成物。
（２）熱産生交感神経を活性化させるために用いられるものである旨の表示を付した（１）に記載の熱産生交感神経活性化用の経口投与用の組成物。
（３）（１）又は（２）のいずれかに記載の熱産生交感神経活性化用の経口投与用の組成物を製造する方法であって、ウド（Ａｒａｌｉａｃｏｒｄａｔａ）のエキスと、経口投与用の組成物で使用されている任意の成分とを加工して前記熱産生交感神経活性化用の経口投与用の組成物を製造する方法。
【０００６】
【発明の実施の形態】
（１）本発明の熱産生交感神経活性化剤
本発明の熱産生交感神経活性化剤は、ウコギ科（Ａｒａｌｉａｃｅａｅ）のタラノキ属植物（Ａｒａｌｉａ）ウド（Ａｒａｌｉａｃｏｒｄａｔａ）のエキスからなる。使用する部位としては、特段の限定が無いが、根茎を用いることが特に好ましい。本発明で言う、これらのエキスとは、植物体そのものを粉砕など加工した加工物、植物体乃至はその加工物に溶媒を加え、抽出した抽出物、抽出物から溶媒を除去した溶媒除去物、抽出物乃至はその溶媒除去物を更にカラムクロマトグラフィーや液液抽出などで分画精製した、分画精製物などの総称を意味する。本発明の熱産生交感神経活性化剤としては、溶媒抽出物或いはその溶媒除去物が好ましい。溶媒抽出物は、植物体乃至はその加工物に、１〜１０重量倍の溶媒を加え、室温であれば数日間、沸点付近の温度であれば数時間浸漬することにより製造することができる。溶媒としては、通常この様な抽出に用いられている溶媒であれば特段の限定はされないが、極性溶媒が特に好ましく例示できる。極性溶媒としては、水、エタノール、イソプロパノール、ブタノール、１，３−ブタンジオール等のアルコール類、酢酸エチルや蟻酸メチルなどのエステル類、ジエチルエーテルやテトラヒドロフラン等のエーテル類、アセトンやメチルエチルケトン等のケトン類、クロロホルムや塩化メチレン等のハロゲン化炭化水素類、アセトニトリル等のニトリル類などが好ましく例示でき、水及び／又はアルコールが特に好ましい。これは、溶出特性と安全性の観点からである。かくして得られたウコギ科（Ａｒａｌｉａｃｅａｅ）のウド（Ａｒａｌｉａｃｏｒｄａｔａ）のエキスは、後記実施例に示す如く、優れた熱産生交感神経活性化作用を有する。この様な作用により、生体全体の熱エネルギー産生を促進し、過剰に存在する脂質を熱に変換させ、脂質の蓄積を抑制する。更に、次に示す如く、ウコギ科（Ａｒａｌｉａｃｅａｅ）ウド（Ａｒａｌｉａｃｏｒｄａｔａ）のエキスは、熱産生タンパク質も活性化するため、二つの異なるメカニズムにより、脂質の蓄積を抑制することができる。この意味に於いても、本発明の熱産生交感神経活性化剤は、従来にない優れた効果を有すると言える。本発明の熱産生交感神経活性化剤の好ましい用量は、成人１日あたり、２００〜１００００ｍｇを１回乃至は数回に分けて経口的に摂取することである。特に好ましい用量は一回の摂取量が２００ｍｇ以上であることである。この為には、本発明の経口投与用の組成物に於いては、本発明の熱産生交感神経活性化剤を５０〜９０重量％含有することが好ましい。
【０００７】
＜製造例１＞
ウコギ科(Araliaceae)のウド(Aralia cordata)の老根及び細い根５００ｇに５Ｌの５０％エタノールを加え、攪拌しながら２時間、９０℃で加熱し、室温まで冷却した後、濾過して不溶物を取り除き、更に減圧濃縮をして、その後、凍結乾燥し、本発明の熱産生交感神経活性化剤１を得た。
【０００８】
＜製造例２＞
ハス科（Nelumbonaceae）のハス(Nelumbo nucifera Gaertner)の種子の仁（蓮肉）５００ｇに５Ｌの５０％エタノールを加え、一週間室温で抽出後、濾過して不溶物を取り除き、更に減圧濃縮をして、その後、凍結乾燥し、本発明の熱産生交感神経活性化剤２を得た。
【０００９】
マウスの肩胛骨間褐色脂肪組織中の熱産生タンパク質の発現促進実験
８週齢のddY系雄性マウスを９匹を一群とし、飼料として基礎飼料ＭＦに精製ラードを２０％添加し、被験物質として熱産生交感神経活性化剤１又は２を５％添加し、マウスに４週間自由摂取させた。その後、肩胛骨間褐色脂肪組織を採取し、遠心分離により粗ミトコンドリア画分を得た。画分中のタンパク質濃度を５μｇ／１０μＬに希釈後、ウェスタンブロットによる熱産生タンパク質の検出を行った。検出されたバンド強度を数値化し、ベヒクル群の値を１００とした時の相対的な熱産生タンパク質含量を求めた。結果を表１に示す。これより、本発明の熱産生交感神経活性化剤は、熱産生タンパク質の発現も促進し、脂質を熱エネルギーに変換していることがわかる。
【００１０】
【表１】

【００１１】
（２）本発明の経口投与用の組成物
本発明の経口投与用の組成物は、上記本発明の熱産生交感神経活性化剤を含有することを特徴とする。かかる熱産生交感神経活性化剤は唯一種を含有させることもできるし、二種以上を組み合わせて含有させることもできる。本発明に言う経口投与用の組成物とは、経口で投与される製剤の総称を意味し、健康食品を含めた食品、飲料、経口投与医薬品等を包含する。本発明の経口投与用の組成物としては、食品が特に好ましい。これは、ウコギ科のタラノキ属植物及びスイレン科乃至はハス科のハス属植物の何れの植物も食品としての長い実績を有するためである。本発明の経口投与用の組成物は、必須成分であるウコギ科のタラノキ属植物及びスイレン科乃至はハス科のハス属植物のエキス以外に、通常上記の組成物で使用されている任意の成分を含有することができる。かかる任意成分としては、白糖等の糖衣剤、乳糖等の賦形剤、デンプンや結晶セルロースなどの崩壊剤、ゼイン、ゼラチン、シェラック等の被覆剤、ヒドロキシプロピルセルロースなどの結合剤、大豆レシチン、ショ糖脂肪酸エステル等の界面活性剤、ステアリン酸マグネシウム、タルク、ロウ類等の滑沢剤、軽質無水ケイ酸、乾燥水酸化アルミニウムゲル等の流動促進剤、生理食塩水、ブドウ糖水溶液等の希釈剤、矯味矯臭剤、着色剤、殺菌剤、防腐剤、香料等が好ましく例示できる。本発明の経口投与用の組成物は、必須成分の本発明の熱産生交感神経活性化剤と任意の成分を常法に従って処理することにより製造することができる。
【００１２】
【実施例】
以下に、実施例を挙げて、本発明について更に詳細に説明を行うが、本発明が、かかる実施例にのみ限定されないことは言うまでもない。
【００１３】
＜実施例１＞
熱産生交感神経活性化剤１を用いて、熱産生交感神経活性化用の経口投与組成物を作成した。即ち、重量５０ｍｇのカプセルに熱産生交感神経活性化剤１を１００ｍｇ充填し、本発明の経口投与用の組成物１（健康食品）を得た。
【００１４】
＜比較例１＞
熱産生交感神経活性化剤２を用いて、熱産生交感神経活性化用の経口投与組成物を作成した。即ち、重量５０ｍｇのカプセルに熱産生交感神経活性化剤２を１００ｍｇ充填し、本発明の経口投与用の組成物２（健康食品）を得た。
【００１５】
＜実施例３＞
ボランティアを用いて、実施例１、および比較例１の熱産生交感神経活性化用の経口投与組成物１、２の、熱産生交感神経への作用を調べた。即ち、１群３人、３群計９名を用い、１群はカプセルのみを服用し、１群は実施例１の熱産生交感神経活性化用の組成物１を２カプセル（２００ｍｇ）を服用し、残る１群は比較例１の熱産生交感神経活性化用の組成物２を２カプセル（２００ｍｇ）を服用し、酸素マスクを付け、呼気を集めた。又、心電図も装着した。呼気の炭酸ガスと酸素の割合より、常法に従い呼吸商（ＲＱ：ＲｅｓｐｉｒａｔｏｒｙＱｕｏｔｉｅｎｔ）を求め、心電図の波形のパワースペクトル分析（（１）ＨｉｄｅｔｏｓｈｉＵｅｅｔ．ａｌ．ＡｎｎａｌｓｏｆＮｏｎｉｎｖａｓｉｖｅＥｌｅｃｔｒｏｃａｒｄｉｏｌｏｇｙ（２０００）５，３３６−３４５、（２）ＩｎｔｅｒｎａｔｉｏｎａｌＪ．ｏｂｅｓｉｔｙ（１９９９）２３，７９３−８００）から、熱産生交感神経の活動指標（心拍変動パワー）を求めた。心拍変動パワーの大きさが大きいほど、熱産生に関与する交感神経の活動度が高く、熱産生を生体に促していることを示す。心拍変動パワーの結果を図１に示す。これより、本発明の熱産生交感神経活性化用の組成物が、熱産生交感神経を活性化し、脂質代謝を高め、脂質を優先的に燃焼させていることがわかる。
【００１６】
＜実施例４＞
以下に示す処方に従って、本発明の経口投与用の組成物である食品を作成した。即ち、イの成分を流動層造粒装置に仕込み、２０％エタノール２０重量部を噴霧しながら流動層造粒を行い、４０℃で５時間送風乾燥した後、１００ｍｇ錠に打錠成形し、これに糖衣パンにて、ロの液を噴霧、送風しながら被覆を行い、１５０ｍｇ錠に加工し、本発明の熱産生交感神経活性化用の組成物３（健康食品）を得た。
イ
結晶セルロース５０重量部
ヒドロキシプロピルセルロース５重量部
熱産生交感神経活性化剤１４５重量部
ロ
ゼイン９重量部
カプリル酸モノグリセリド１重量部
エタノール９０重量部
【００１７】
＜比較例２＞
以下に示す処方に従って、本発明の経口投与用の組成物である食品を作成した。即ち、イの成分を流動層造粒装置に仕込み、２０％エタノール２０重量部を噴霧しながら流動層造粒を行い、４０℃で５時間送風乾燥した後、１００ｍｇ錠に打錠成形し、これに糖衣パンにて、ロの液を噴霧、送風しながら被覆を行い、１５０ｍｇ錠に加工し、本発明の熱産生交感神経活性化用の組成物４（健康食品）を得た。
イ
結晶セルロース５０重量部
ヒドロキシプロピルセルロース５重量部
熱産生交感神経活性化剤２４５重量部
ロ
ゼイン９重量部
カプリル酸モノグリセリド１重量部
エタノール９０重量部
【００１８】
【発明の効果】
本発明によれば、新しい脂質蓄積抑制のメカニズムに基づいた脂質蓄積抑制素材を提供することができる。
【図面の簡単な説明】
【図１】実施例３の心電図のパワースペクトル分析の結果を示す図である。[0001]
BACKGROUND OF THE INVENTION
The present invention relates to a heat-producing sympathetic nerve activator and a composition for oral administration containing the same.
[0002]
[Prior art]
Obesity has become a major social problem in the present day when nutritional status has improved too much. Reflecting this, the word “diet” in Japan directly means a reduction in calorie intake due to dietary restrictions. Many so-called health foods have appealed for "diet". Health foods that appeal to such a “diet” can be broadly classified as follows: 1) Administer non-digestible fiber such as glucomannan or gelled product made from it to physically prevent food from entering the digestive tract. (Japanese Patent Laid-Open No. 6-181702) 2) Promotes the expression of heat-producing protein (Uncoupling Protein; UCP) like capsaicin or goldfish, enhances the conversion of lipid to thermal energy, and suppresses lipid accumulation There are two types (Japanese Patent Laid-Open No. 2000-189108). However, a method for activating the heat-producing sympathetic nerve that controls heat production is not known. Furthermore, there is no known relationship between the heat production in the living body and the extracts of the genus Arachnaceae, the water lily family, or the lotus family of the lotus family. Moreover, in order to suppress excessive lipid accumulation in a complex lipid accumulation system, it is necessary to deal with not only a single mechanism but also a complex mechanism. The elucidation of the mechanism of inhibition and the development of materials for inhibiting lipid accumulation have been desired.
[0003]
On the other hand, the Arachaceae plant (Araliaceae) is used as a folk medicine for sweating, antipyretic, analgesic, headache, toothache, rheumatism, neuralgia, and nymphacaccac or lotus It has been known that lotus plants of the family Nelumbonaceae (Nelumbo) are used as folk medicines for the purpose of astringency, sedation, and mild nourishment, but these extracts activate heat-producing sympathetic nerves It was not known at all to have an action, nor was it administered orally for the purpose of heat-generating sympathetic nerve activation.
[0004]
[Problems to be solved by the invention]
The present invention has been made under such circumstances, and an object of the present invention is to provide a lipid accumulation-inhibiting material based on a new lipid accumulation-inhibiting mechanism.
[0005]
[Means for Solving the Problems]
In view of such a situation, the present inventors have sought for a lipid accumulation-inhibiting material based on a new lipid accumulation-inhibiting mechanism, and as a result of earnest research efforts, the present inventors have succeeded in studying the genus Araliaceae (Aralia). It has been found that the extract of Udo (Aralia cordadata) has the action of activating the heat-producing sympathetic nerve, and that action can suppress lipid accumulation, and has led to the completion of the invention. That is, this invention relates to the technique shown below.
(1) A composition for oral administration for activation of heat-producing sympathetic nerves, which contains an extract of udo (Aralia corda).
(2) The composition for oral administration for activating the heat-producing sympathetic nerve according to (1), which is labeled to be used for activating the heat-producing sympathetic nerve.
( 3 ) A method for producing an orally administrable composition for activating the heat-producing sympathetic nerve according to any one of (1) and (2) , wherein an extract of udo (Aralia cordadata) and for oral administration The composition for oral administration for the said heat-producing sympathetic nerve activation is processed by processing the arbitrary components currently used in the composition of this.
[0006]
DETAILED DESCRIPTION OF THE INVENTION
(1) heat production sympathetic activator heat production sympathetic activator present invention of the present invention consists of extract of Aralia plants Araliaceae (Araliaceae) (Aralia) Udo (Aralia cordata). The site of use, but there is no particular limitation, it is particularly preferable to use rhizome. In the present invention, these extracts are a processed product obtained by pulverizing a plant body itself, a plant or a processed product added with a solvent, an extracted extract, a solvent removed product obtained by removing the solvent from the extract, It means a generic term for fractionated purified products obtained by fractionating and purifying extracts or their solvent-removed products by column chromatography or liquid-liquid extraction. As the heat-producing sympathetic nerve activator of the present invention, a solvent extract or a solvent removed product thereof is preferable. The solvent extract can be produced by adding 1 to 10 times by weight of a solvent to a plant or processed product and immersing it for several days at room temperature or for several hours at a temperature near the boiling point. The solvent is not particularly limited as long as it is a solvent usually used for such extraction, but a polar solvent can be particularly preferably exemplified. Polar solvents include water, ethanol, isopropanol, butanol, alcohols such as 1,3-butanediol, esters such as ethyl acetate and methyl formate, ethers such as diethyl ether and tetrahydrofuran, and ketones such as acetone and methyl ethyl ketone. Preferred examples include halogenated hydrocarbons such as chloroform and methylene chloride, and nitriles such as acetonitrile, with water and / or alcohol being particularly preferred. This is from the viewpoint of elution characteristics and safety. The extract of Araliaceae obtained in this way has an excellent heat-producing sympathetic nerve activation action as shown in the examples described later. By such an action, heat energy production of the whole living body is promoted, excess lipid is converted into heat, and lipid accumulation is suppressed. Furthermore, as shown below, the extract of Araliaceae udara (Aralia cordadata) also activates heat-producing proteins, and therefore, lipid accumulation can be suppressed by two different mechanisms. Also in this sense, it can be said that the heat-producing sympathetic nerve activator of the present invention has an excellent effect that has not been achieved conventionally. A preferred dose of the thermogenic sympathetic nerve activator of the present invention is to take 200 to 10000 mg orally in one or several divided doses per day for an adult. A particularly preferable dose is that a single intake is 200 mg or more. For this purpose, the composition for oral administration of the present invention preferably contains 50 to 90% by weight of the heat-producing sympathetic nerve activator of the present invention.
[0007]
<Production Example 1>
Add 5 L of 50% ethanol to 500 g of old and thin roots of Araliaceae (Araliaceae), heat at 90 ° C. with stirring for 2 hours, cool to room temperature, filter and insoluble matter Was further concentrated under reduced pressure, and then freeze-dried to obtain the heat-producing sympathetic nerve activator 1 of the present invention.
[0008]
<Production Example 2>
Add 5 liters of 50% ethanol to 500 g of seeds (Nelumbo nucifera Gaertner) of the lotus family (Nelumbon naceifera), extract at room temperature for one week, filter to remove insolubles, and concentrate under reduced pressure. Thereafter, freeze-drying was performed to obtain the heat-producing sympathetic nerve activator 2 of the present invention.
[0009]
Experiment on the promotion of the expression of heat-producing protein in the interscapular brown adipose tissue of mice Nine ddY male mice at 8 weeks of age were made into a group, 20% of purified lard was added to the basic feed MF as a feed, and heat was generated as a test substance The sympathetic nerve activator 1 or 2 was added at 5%, and the mice were ingested freely for 4 weeks. Thereafter, brown adipose tissue between the shoulder and ribs was collected, and a crude mitochondrial fraction was obtained by centrifugation. The protein concentration in the fraction was diluted to 5 μg / 10 μL, and then the heat-generated protein was detected by Western blot. The detected band intensity was quantified, and the relative thermogenic protein content was determined when the value of the vehicle group was 100. The results are shown in Table 1. From this, it can be seen that the heat-producing sympathetic nerve activator of the present invention also promotes the expression of heat-producing proteins and converts lipids into heat energy.
[0010]
[Table 1]

[0011]
(2) Composition for oral administration of the present invention The composition for oral administration of the present invention is characterized by containing the heat-producing sympathetic nerve activator of the present invention. Such a heat-producing sympathetic nerve activator can contain only one species or can contain two or more species in combination. The composition for oral administration referred to in the present invention means a general term for preparations administered orally, and includes foods including health foods, beverages, orally administered pharmaceuticals, and the like. As the composition for oral administration of the present invention, a food is particularly preferable. This is because all the plants of the genus Arachnaceae and the water lily family or the lotus family have a long track record as foods. The composition for oral administration of the present invention is an optional component that is usually used in the above-mentioned composition in addition to the essential component extracts of the genus Arachnaceae and the lotus family Can be contained. Such optional ingredients include sugar coatings such as sucrose, excipients such as lactose, disintegrants such as starch and crystalline cellulose, coating agents such as zein, gelatin and shellac, binders such as hydroxypropylcellulose, soybean lecithin, Surfactants such as sugar fatty acid esters, lubricants such as magnesium stearate, talc, waxes, glidants such as light anhydrous silicic acid, dry aluminum hydroxide gel, diluents such as physiological saline, aqueous glucose solution, Flavoring agents, coloring agents, bactericides, preservatives, fragrances and the like can be preferably exemplified. The composition for oral administration of the present invention can be produced by treating the heat-producing sympathetic nerve activator of the present invention, which is an essential component, and an optional component according to a conventional method.
[0012]
【Example】
Hereinafter, the present invention will be described in more detail with reference to examples. Needless to say, the present invention is not limited to such examples.
[0013]
<Example 1>
An orally administered composition for activating the heat-producing sympathetic nerve was prepared using the heat-producing sympathetic nerve activator 1. That is, a capsule having a weight of 50 mg was filled with 100 mg of the thermogenic sympathetic nerve activator 1 to obtain a composition 1 (health food) for oral administration of the present invention.
[0014]
< Comparative Example 1 >
Using the heat-producing sympathetic nerve activator 2, an oral administration composition for heat-producing sympathetic nerve activation was prepared. That is, a capsule having a weight of 50 mg was filled with 100 mg of the thermogenic sympathetic nerve activator 2 to obtain the composition 2 (health food) for oral administration of the present invention.
[0015]
<Example 3>
Using volunteers, the effects of the orally administered compositions 1 and 2 for activating the heat-producing sympathetic nerve of Example 1 and Comparative Example 1 on the heat-producing sympathetic nerve were examined. That is, 3 people per group, 9 people in 3 groups, 1 group taking only capsules, 1 group taking 2 capsules (200 mg) of composition 1 for activating the heat-producing sympathetic nerve of Example 1 Then, the remaining one group took 2 capsules (200 mg) of the composition 2 for activating the heat-producing sympathetic nerve of Comparative Example 1 , attached an oxygen mask, and collected exhaled breath. An electrocardiogram was also worn. The respiratory quotient (RQ: Respiratory Quotient) is obtained from the ratio of carbon dioxide and oxygen in the breath according to a conventional method, and the power spectrum analysis of the waveform of the electrocardiogram ((1) Hideto Ue et al. Anals of Nonelectroactive Electrocardiology 5, 2000) 336-345, (2) International J. obesity (1999) 23, 793-800), the activity index (heart rate variability power) of the heat-producing sympathetic nerve was determined. The larger the heart rate variability power, the higher the activity of sympathetic nerves involved in heat production, indicating that the body is promoting heat production. The result of the heart rate variability power is shown in FIG. This shows that the composition for activating the heat-producing sympathetic nerve of the present invention activates the heat-producing sympathetic nerve, enhances lipid metabolism, and preferentially burns the lipid.
[0016]
<Example 4>
According to the prescription shown below, the food which is the composition for oral administration of this invention was created. That is, the component (a) is charged into a fluidized bed granulator, fluidized bed granulated while spraying 20 parts by weight of 20% ethanol, blown and dried at 40 ° C. for 5 hours, and then compressed into 100 mg tablets. In a sugar-coated pan, coating was carried out while spraying and blowing the loquat liquid and processing into 150 mg tablets to obtain composition 3 (health food) for activating the heat-producing sympathetic nerve of the present invention.
A crystalline cellulose 50 parts by weight Hydroxypropyl cellulose 5 parts by weight Heat-producing sympathetic nerve activator 1 45 parts by weight Rosein 9 parts by weight Caprylic acid monoglyceride 1 part by weight Ethanol 90 parts by weight
< Comparative example 2 >
According to the prescription shown below, the foodstuff which is a composition for oral administration of this invention was created. That is, the component (a) is charged into a fluidized bed granulator, fluidized bed granulated while spraying 20 parts by weight of 20% ethanol, blown and dried at 40 ° C. for 5 hours, and then compressed into 100 mg tablets. In a sugar-coated bread, coating was carried out while spraying and blowing the loquat liquid and processed into 150 mg tablets to obtain the composition 4 (health food) for heat-producing sympathetic nerve activation of the present invention.
A crystalline cellulose 50 parts by weight Hydroxypropyl cellulose 5 parts by weight Heat-producing sympathetic nerve activator 2 45 parts by weight Rosein 9 parts by weight Caprylic acid monoglyceride 1 part by weight Ethanol 90 parts by weight
【The invention's effect】
ADVANTAGE OF THE INVENTION According to this invention, the lipid accumulation suppression raw material based on the new mechanism of lipid accumulation suppression can be provided.
[Brief description of the drawings]
FIG. 1 is a diagram showing the result of power spectrum analysis of an electrocardiogram of Example 3. FIG.

Claims

A composition for oral administration for heat-producing sympathetic nerve activation, comprising an extract of udo (Aralia corda).

The composition for oral administration for heat-producing sympathetic nerve activation according to claim 1, which is labeled as being used to activate the heat-producing sympathetic nerve.

A method for producing an orally administered composition for activating the heat-producing sympathetic nerve according to any one of claims 1 or 2 , comprising an extract of udo (Aralia cordadata) and an orally administered composition. A method for producing an orally administrable composition for activating the heat-producing sympathetic nerve by processing any of the ingredients used in the method.