JP4673334B2 - Soft capsule manufacturing apparatus and soft capsule manufacturing method - Google Patents

Description

  The present invention relates to a soft capsule manufacturing apparatus and a soft capsule manufacturing method for manufacturing soft capsules.

  Conventionally, soft capsules in which a drug solution is filled in a capsule film made of an animal raw material such as gelatin or a vegetable raw material such as starch are mainly known as pharmaceuticals. There are various types of soft capsules, and there are so-called double soft capsules. For example, as shown in the cross-sectional view of FIG. 8, the double soft capsule 8 includes a first film 81 made of gelatin or the like, a chemical liquid 82 filled in the first film 81, and a mixture in the chemical liquid 82. The plurality of included soft capsules 83, 83,. Each encapsulated soft capsule 83 includes a second film 831 and a chemical solution 832 filled in the second film 831. For example, when the double soft capsule 8 is taken, the first film 81 is first disintegrated in the stomach, and the internal soft capsules 83, 83,. Supplied. When the time further elapses, the second film 831 of the internal soft capsule 83 is collapsed, and the chemical solution 832 filled therein is supplied. Therefore, if this double soft capsule 8 is utilized, it becomes possible to supply a chemical | medical solution in a body with a time lag.

  This double soft capsule 8 is conventionally manufactured by a manufacturing method called a flat plate method, but since this flat plate method manufactures the double soft capsule 8 by hand, a large number of people are required, which is very laborious. The efficiency is low.

  Therefore, the present inventors tried to manufacture double soft capsules using a so-called rotary manufacturing apparatus. As this rotary manufacturing apparatus, for example, there is a soft capsule manufacturing apparatus described in Patent Document 1 below.

  The structure of the soft capsule manufacturing apparatus will be described with reference to FIGS. FIG. 4 is a perspective view showing the internal structure of the soft capsule manufacturing apparatus. The soft capsule manufacturing apparatus 1 includes a sheet forming unit 2, a chemical solution supply unit 3, a chemical solution filling unit 4A, and a capsule forming unit 5. When using this soft capsule manufacturing apparatus 1 to manufacture a general soft capsule, that is, a soft capsule in which a chemical solution is encapsulated in a film made of a gelatin sheet, first, the chemical solution is put into the hopper 31 of the chemical solution supply unit 3. In parallel with this, the sheet forming unit 2 forms a gelatin sheet.

  Next, the chemical liquid supplied into the hopper 31 is supplied to the chemical liquid filling unit 4 </ b> A via the supply tube 34 by the plunger pump 32. The chemical solution supplied to the chemical solution filling unit 4 </ b> A is jetted between the die rolls 51 and 51 of the capsule forming unit 5. On the other hand, in the sheet forming sections 2 and 2, the manufactured gelatin sheets 13 and 13 are conveyed to the die rolls 51 and 51 by the winding rollers 24 and 24, and the conveyed gelatin sheets 13 and 13 are between the die rolls 51 and 51. It is sandwiched between and heat sealed. At that time, a chemical solution is injected between the gelatin sheets 13 and 13, and the gelatin sheet is cut into a capsule shape with a die on the outer peripheral surface of the die rolls 51 and 51, thereby producing a soft capsule in which the gelatin film is filled with the chemical solution. Is done.

  The structure of the chemical solution filling unit 4A in the soft capsule manufacturing apparatus 1 will be described in more detail with reference to FIGS. 5-7 is a figure which shows the structure of this chemical | medical solution filling part 4A, FIG. 5 is a perspective view, FIG. 6 is a top view, FIG. 7 is a side view.

  As shown in FIG. 5, the chemical solution filling unit 4 </ b> A includes a tube assembly bottom 41 </ b> A, a first pad 42 </ b> A, a slide valve 43 </ b> A, a return pad 46, a dispersion plate 47, a second pad 44, and a wedge 45. FIG. 5 shows a state before connecting the respective members. Actually, these respective members are stacked and connected and installed in the soft capsule manufacturing apparatus 1.

  The tube assembly bottom 41A is provided with the same number of injection holes 415, 415,... As the number of supply tubes 34, 34,. The supply tubes 34, 34,... Are connected to the tube assembly bottom 41A via joints 416, 416.

  The slide valve 43 </ b> A is a member that functions to open and close a valve that allows the chemical solution supplied from the chemical solution supply unit 3 to pass through all the way or to return to the hopper 31 of the chemical solution supply unit 3. The tube assembly bottom 41A is laminated and connected via 42A. This valve opening / closing operation is performed by operating the lever 433. The slide valve 43A is provided with liquid passage holes 431, 431,... At positions corresponding to the injection holes 415, 415,... The chemical solution is passed through the dispersion plate 47 through 432, 432,. Further, a return hole 434 </ b> A through which a chemical solution to be returned to the hopper 31 is passed is provided at a substantially central portion thereof. In the first pad, passage holes 421A, 421A,..., Return holes are provided at positions corresponding to the liquid passage holes 431, 431,... And return holes 434A, 434A,. Holes 422A, 422A,... Are provided, respectively.

  The dispersion plate 47 disperses the chemical liquid that has passed through the slide valve 43 </ b> A into the central part and supplies it to the wedge 45, and the one that returns to the hopper 31 without being supplied to the wedge 45. It is a member having a function to make it. The dispersion plate 47 is laminated and connected to the slide valve 43 </ b> A via the return pad 46. In the return pad 46, passage holes 461, 461,... Are provided at positions corresponding to the liquid passage holes 431, 431,..., And an elongated return hole 462 is formed in the center. Is provided.

  Here, referring to FIG. 5, the chemical liquid is supplied to the dispersion plate 47 from the ten liquid passage holes 431, 431,... Of the slide valve 43 A, but the wedge 45 has supply holes 452, 452,. .. Are provided only seven, and three chemical liquids out of the chemical liquids supplied from the liquid passage holes 431, 431,... Are surplus. Therefore, in this dispersion plate 47, only seven chemical liquids out of ten liquid passing holes 431, 431,... Are centrally provided by supply holes 471, 471,. The liquid is collected in the section and supplied to the wedge 45. The remaining three chemicals are supplied to the return grooves 473, 473,... That do not penetrate, and the tubes are passed through the return hole 462, the return hole 434A, and the return hole 422A of the return pad 46. The product is returned to the hopper 31 through the return tube 35 connected to the return joint 418 of the assembly bottom 41A.

  The wedge 45 is configured to inject a chemical solution passed through the dispersion plate 47 toward the die roll 51, and has seven supply holes 452, 452,. Yes. The chemical solution is supplied from the dispersion plate 47 to the supply holes 452, 452,. The wedge 45 is laminated and connected to the dispersion plate 47 via the second pad 44. In the second pad 44, passage holes 441, 441,... Are provided at positions corresponding to the supply holes 452, 452,. The wedge 45 has a wedge shape so that it can be inserted between the die rolls 51 and 51. At the tip, there are provided discharge holes 451, 451,... Communicating with the supply holes 452, 452,..., And a chemical solution is ejected from the discharge holes 451, 451,.

  As described above, the chemical liquid that passes through the chemical liquid filling unit 4A is dispersed into the liquid that is passed by the dispersion plate 47 and the liquid that is returned, because the soft capsule manufacturing apparatus 1 is used for general purposes. That is, the number of the discharge holes 451, 451,... Of the wedge 45 varies depending on the size of the soft capsule to be manufactured and the amount of the chemical solution to be filled therein. It takes time and effort to adjust the number of. Therefore, such a dispersion plate 47 is used to manufacture various soft capsules.

  The inventors tried to manufacture a double capsule using the conventional soft capsule manufacturing apparatus 1 configured as described above, and could not manufacture it successfully. The reason will be described with reference to FIGS. Since the conventional soft capsule manufacturing apparatus 1 uses the dispersion plate 47 as described above, the chemical solution supplied from the injection hole 415 passes straight up to the supply hole 471 of the dispersion plate 47. The passage holes 441, the supply holes 452, and the discharge holes 451 after the dispersion plate 47 are supplied after being cranked once via the liquid collection groove 472. FIG. 7 (a) shows a chemical solution flow route R 1, and it can be seen that the chemical solution is cranked once at the dispersion plate 47. FIG. 7B is an enlarged view of this portion. After the chemical solution is supplied from the supply hole 471, it passes through the liquid collecting groove 472 orthogonal to the supply hole 471 and is discharged toward the passage hole 441. Become.

  In order to manufacture a double soft capsule by the soft capsule manufacturing apparatus 1, a solid mixed solution filled in the first film 81 shown in FIG. 8 in the hopper 31, that is, a liquid obtained by mixing the encapsulated soft capsule 83 in the drug solution 82 is filled. To do. Then, the solid mixed solution passes through the chemical solution filling unit 4A along the route R1 shown in FIG. 7A. However, the encapsulated soft capsule 83 in the solid mixed solution tends to be clogged in the portion shown in FIG. 7B, and the liquid ejected from the discharge hole 451 may not be mixed with the encapsulated soft capsule 83. The amount of the encapsulated soft capsule 83 contained in the jetted liquid varied considerably, and it was not possible to produce a double soft capsule well.

Japanese Patent No. 3836494

  The present invention has been made to solve the above-described problems, and an object of the present invention is to provide a soft capsule manufacturing apparatus and a soft capsule manufacturing method capable of efficiently mass-producing double soft capsules.

In order to achieve the above object, the soft capsule manufacturing apparatus according to the present invention conveys two coating sheets between a pair of die rolls that are arranged opposite to each other and rotate reversely , and a solid is contained in the liquid filled in the hopper. The mixed solid solution is injected through a wedge fitted above the outer periphery of the die roll, filled between the coating sheets, and bites the blades of the capsule pockets arranged on the outer peripheral surface of the die roll. A soft capsule manufacturing apparatus for manufacturing a soft capsule in which the solid mixed liquid is filled in a capsule film by simultaneously heat-sealing the film sheet and die-molding into a capsule shape, wherein the solid mixed liquid in the hopper is A tube assembly that distributes the pump to be pumped and the solid mixture pumped from this pump to the tube And a tube assembly bottom having a plurality of injection holes into which the solid mixed solution is fed from the tube assembly top through the tube, and a solid mixed solution fed from the tube assembly bottom. It is a hole through which the liquid is passed and has the same number of liquid holes as the injection hole, and can be operated between a slide valve that can be operated to pass all the solid mixed solution or all the return, and the die roll. It is a wedge-shaped shape, and is a hole for discharging the solid mixed solution fed to the tip thereof through the liquid passage hole between the die rolls, and has the same number of discharge holes as the liquid passage hole. The tube assembly bottom, and the slide valve. And formed by laminating connecting said wedge, the injection hole, the flow-through holes and the discharge holes, and wherein the communicating linearly.

Further, in order to achieve the above object, the soft capsule manufacturing method according to the present invention includes a pump for sending out a solid mixed liquid in which a solid is mixed in a liquid filled in a hopper, and a solid mixed liquid sent out from this pump. A tube assembly top that distributes the tubes, a tube assembly bottom that has a plurality of injection holes through which the solid mixed solution is fed from the tube assembly top, and is fed from the tube assembly bottom. A slide valve through which the solid mixed liquid is passed and has the same number of through holes as the injection hole, and can be operated to completely pass or return the solid mixed liquid; A hole that discharges the solid mixed solution fed through the liquid hole. And a wedge-shaped wedge having the same number of discharge holes as the number of liquid passing holes, and a pair of die rolls that are disposed opposite to each other with the front ends of the wedges interposed therebetween and that rotate in reverse from each other, A soft capsule manufacturing method using a soft capsule manufacturing apparatus in which the tube assembly bottom, the slide valve, and the wedge are laminated and connected, wherein two coating sheets are conveyed between the die rolls, while the solid mixing in the hopper The liquid is filled between the coating sheets by passing the liquid through the tube assembly top through the injection hole, the liquid passage hole, and the discharge hole in a straight line, and is ejected from the discharge hole. The coating sheet is heat-sealed by meshing the blades of the capsule pockets arranged on the outer peripheral surface. By die-cut into a capsule shape and simultaneously Le, the solid liquid mixture, characterized in that the production of soft capsules filled in the capsule shell.

  In the present invention, the injection hole of the tube assembly bottom of the soft capsule manufacturing apparatus, the liquid injection hole of the slide valve, and the discharge hole of the wedge are configured to communicate linearly. With this configuration, the number of tubes connected to the tube assembly bottom is the same as the number of injection holes, liquid passage holes, and discharge holes. Therefore, there is no surplus in the supplied solid mixed liquid, and no liquid is returned to the hopper in normal operation.

  As the solid mixed solution, for example, a soft capsule containing a chemical solution is mixed in the chemical solution.

  Further, in the present invention, as a raw material for the film sheet that becomes a capsule film, for example, animal raw materials such as gelatin contained in cattle, pigs, and fish can be used, and not limited to animal raw materials, for example, included in corn Vegetable raw materials such as starch and other raw materials can also be used.

  According to the present invention, in the soft capsule manufacturing apparatus, when the double soft capsule is manufactured by linearly communicating the injection hole of the tube assembly bottom, the liquid flow hole of the slide valve, and the discharge hole of the wedge, Solids in the solid mixture can be prevented from clogging, and double soft capsules can be mass-produced efficiently, and a conventional dispersion plate is not required, and the manufacturing cost of the soft capsule manufacturing apparatus can be reduced.

  Embodiments of the present invention will be described below with reference to the accompanying drawings. Note that the soft capsule manufacturing apparatus of the present invention has the same structure as the conventional soft capsule manufacturing apparatus shown in FIG. 4 except that the number of the chemical solution filling section and the supply tubes is different. Therefore, in the following description of the soft capsule manufacturing apparatus and the soft capsule manufacturing method of the present invention, FIG. 4 is also used, particularly the portions that are different from the prior art are described with emphasis, and the same portions are described in the background art. Detailed description is omitted.

  FIG. 1 is a perspective view showing the structure of a chemical solution filling unit of the soft capsule manufacturing apparatus of the present invention, FIG. 2 is a top view of the chemical solution filling unit, and FIG. 3 is a side view of the chemical solution filling unit. First, the structure of the chemical solution filling part, which is the main part of the present invention, different from the conventional soft capsule manufacturing apparatus (hereinafter referred to as “conventional example”) will be described with reference to FIGS. This will be explained later with reference to it.

  First, as shown in FIG. 1, the chemical solution filling unit 4 includes a tube assembly bottom 41 </ b> B, a first pad 42 </ b> B, a slide valve 43 </ b> B, a second pad 44, and a wedge 45. When the hopper 31 shown in FIG. 4 is filled with the solid mixed solution 12, that is, the one composed of the chemical solution 82 and the encapsulated soft capsule 83 filled in the first film 81 shown in FIG. The chemical solution filling unit 4 is passed through and ejected between the die rolls 51 and 51. Moreover, the internal soft capsule 83 in which the chemical | medical solution 832 is filled in the 2nd membrane | film | coat 831 as shown in FIG. 8 is manufactured previously by the seamless manufacturing method etc., for example. Unlike the conventional example, the return pad 46 and the dispersion plate 47 are not required.

  The tube assembly bottom 41B has a plurality of injection holes 411, 411,..., A supply tube 34, 34,... And injection holes 411, 411,. Are connected to the soft capsule manufacturing apparatus 1, and there are return joints 414 for connecting to the return tubes. .

  However, unlike the conventional tube assembly bottom 41A, the number of the injection holes 411, 411,... Is 7, and the supply is such that the central portion of the tube assembly bottom 41B is arranged in a straight line in the width direction. .., And the position of the return joint 414 is different. The number of the injection holes 411, 411,... And the supply tubes 34, 34,... Is not limited to seven, and can be appropriately changed by the user. ,... And the number of supply tubes 34, 34,.

  The slide valve 43B has liquid passage holes 431, 431,..., Followed by liquid passage pipes 432, 432,. The structure of the slide valve 43B is different in that the position of the return hole 422B is provided at a position different from the position of the conventional slide valve 43A because the position of the return hole 422B corresponds to the mounting position of the return joint 414. Only.

  The slide valve 43B is similar to the conventional example in that the slide valve 43B is laminated and connected via the tube assembly bottom 41B and the first pad 42B. However, the slide valve 43B is different from the conventional first pad 42A in that it has a return hole 422B. The position of is different.

  The structure of the wedge 45 and the second pad 44 is exactly the same as the conventional one, and the wedge 45 is laminated and connected via the slide valve 43B and the second pad 44.

  FIG. 1 shows a flow route R2 through which the solid mixed solution supplied from the hopper 31 flows, but unlike the conventional example, this flow route R2 has never been cranked. This will be described with reference to FIGS.

  FIG. 2 is a top view of the chemical liquid filling unit 4 and mainly describes the positional relationship between the injection holes 411, 411,..., The liquid passage hole 431 and the discharge hole 451. FIG. 3 is a side view of the chemical liquid filling unit 4 and mainly describes a liquid flow route R2.

  In the chemical solution filling unit 4 used in the present invention, it is understood that the injection holes 411, 411,..., The liquid passage hole 431 and the discharge hole 451 are arranged linearly with reference to FIG. In this way, since the injection holes 411, 411,..., The liquid passage hole 431 and the discharge hole 451 are linearly arranged, the liquid passage route R2 is not cranked as shown in FIG. It becomes a straight line.

  That is, the solid mixed solution supplied from each of the injection holes 411, 411,... Straightly passes through the chemical solution filling unit 4 without being cranked in the chemical solution filling unit 4, and the discharge holes 451, 451,... Further, unlike the conventional example, the solid mixed solution supplied to each of the injection holes 411, 411,... Does not return to the hopper 31 during normal operation, but all from the discharge holes 451, 451,. Erupted.

  Therefore, unlike the conventional example, the solid in the solid mixed solution is not clogged in the chemical solution filling unit 4 in the chemical solution filling unit 4, and the double soft capsule can be manufactured efficiently and satisfactorily.

  Next, another configuration of the soft capsule manufacturing apparatus 1 of the present invention will be described with reference to FIG.

  As shown in FIG. 4, the soft capsule manufacturing apparatus 1 according to the present invention includes a sheet molding unit 2, a chemical solution supply unit 3, a chemical solution filling unit 4, and a capsule molding unit 5. The sheet forming section 2 forms two film sheets (gelatin sheets) 13 and 13 from the solution (gelatin solution) 11, and the capsule forming section 5 heat seals the gelatin sheets 13 and 13 at the same time. A double soft capsule 15 in which the solid mixed liquid 12 is filled in a capsule film (gelatin film) is manufactured by injecting the solid mixed liquid 12 into a capsule shape. The double soft capsule 15 has a structure similar to the double soft capsule 8 shown in FIG.

  The sheet forming unit 2 is a mechanism unit for forming gelatin that becomes a film of the double soft capsule 15 into a continuous sheet, and includes a solution supply unit (gelatin supply unit) 21, a spreader box 22, a forming drum 23, and a winding roller 24. It is configured with.

  A gelatin supply unit (not shown) is composed of a tank for subdivision and a solution hose. For example, a gelatin solution 11 extracted and purified from various raw materials such as cattle, pigs and fish is stored in the tank, and the gelatin solution 11 is stored in the solution hose. Thus, it is transferred to the spreader box 22. In order to prevent the gelatin solution 11 from solidifying during the transfer, the temperature of the solution hose is adjusted by a heater and a sensor (not shown).

  The spreader box 22 has a function of storing a certain amount of the gelatin solution 11 transferred from the solution hose and spreading the gelatin solution 11 thinly on the molding drum 23. The gelatin solution 11 stored in the spreader box 22 is discharged from an elongated gate 221 opened at the bottom of the box, and applied to the surface of the molding drum 23 with a predetermined width and thickness. The spreader box 22 is provided with a heater 222 and a sensor. The heater 222 heats the box to maintain a predetermined temperature, and maintains the sol state of the gelatin solution 11 stored in the box.

  The molding drum 23 is installed directly under the spreader box 22 and is used for solidifying the gelatin solution 11 discharged from the gate 221. The forming drum 23 is rotatably supported by a drive system 27 to be described later, and the gelatin solution 11 applied to the drum surface is cooled and gelled substantially around the outer periphery of the drum, thereby having a predetermined width and thickness. A gelatin sheet 13 continuous in a band shape is formed.

  The hoisting roller 24 is installed at a position where the gelatin sheet 13 formed by the forming drum 23 has almost finished its circulation, and peels off the gelatin sheet 13 that is in close contact with the outer peripheral surface of the drum and supplies it to the capsule forming unit 5 at the subsequent stage. belongs to. In the winding roller 24, four rollers 241 to 244 are alternately rotated in reverse by a drive system 28 described later, and the gelatin sheet 13 peeled off from the forming drum 23 is wound around the roller, and the four rollers The sheet guide 25 is reached while passing in a zigzag manner. Further, the gelatin sheet 13 whose position is adjusted by the sheet guide 25 is supplied to the die roll 51 of the capsule forming unit 5 via the ribbon roller 26.

  The ribbon roller 26 is a roller for accurately guiding the conveyed gelatin sheet 13 to the die roll 51. The outer peripheral surface of the roller is coated with Teflon (registered trademark) so that the gelatin sheet 13 can be smoothly transferred. It has become.

  The first roller 241 located at the lowermost end of the four winding rollers is knurled on the outer peripheral surface of the roller to facilitate the peeling of the gelatin sheet 13 from the molding drum 23, and the gripping force for holding the gelatin sheet 13 is increased. It has been. In addition, the second roller 242 and the third roller 243 located in the middle of the gelatin sheet 13 from the outer peripheral surface of the roller in order to improve the slip of the gelatin sheet 13 sandwiched between the wedge 45 and the die roll 37 at the time of capsule molding. Apply oil to the back and then the front. The fourth roller 244 located at the uppermost end functions as a roller for making the oil application area of the third roller 243 the same as that of the second roller 242.

  The sheet forming unit 2 including the gelatin supply unit 21, the spreader box 22, the forming drum 23, and the winding roller 24 as described above is installed in pairs on the left and right sides centering on the capsule forming unit 5 as shown in FIG. Thus, the two gelatin sheets 13 and 13 formed by the pair of sheet forming portions 2 and 2 are conveyed to the capsule forming portion 5.

  The capsule forming part 5 is a part where the two gelatin sheets 13 and 13 conveyed from the sheet forming parts 2 and 2 on both the left and right sides are heat-sealed and simultaneously die-cut to form a soft capsule 15. Here, a pair of die rolls 51, 51 that rotate in reverse to each other are arranged close to each other, and a curved concave portion 511 for fitting the wedge 45 is formed on the upper periphery of both rollers. A plurality of capsule pockets 512, 512,... Are aligned and opened on the outer peripheral surface of the die roll 51 as a mold for punching the gelatin sheet 13 into a capsule shape, and between the adjacent capsule pockets 512, 512. Is formed with a blade portion (not shown) for cutting out the gelatin sheet 13.

  In the capsule forming unit 5, two gelatin sheets 13 and 13 are supplied between the pair of die rolls 51 and 51, and a wedge 45 is fitted into the upper position thereof, and the solid mixed solution 12 is discharged from the discharge holes 451, 451,. Is injected between the two gelatin sheets 13 and 13 sandwiched between the die rolls 51 and 51. At the same time, the wedge 45 is heated by the heater 453, the gelatin sheet 13 is melted by the heat to enhance the adhesive force, and heat sealing is performed with the pressure when passing through the narrowest portion between the rollers. Further, at this time, the gelatin sheet 13 is cut into a capsule shape by engaging the blade portions (not shown) of the right and left die rolls.

  A chute assembly 52 composed of a strip roller 521 and a mangle roller 522 is disposed at a position below the die roll 51 where the capsule molding has been completed in this way. In the chute assembly 52, the remaining gelatin sheet (remaining sheet) 14 after the mangle roller 522 is rotated to cut out the soft capsule 15 is pulled downward, and the soft capsule 15 left on the sheet side by the rotation of the strip roller 521 is pulled. And the remaining sheet 14 are separated, and only the soft capsule 15 is collected via a shooter disposed in front. The rotation speed of the mangle roller 522 is adjusted so that the remaining sheet 14 is not caught in the die roll 51 and the remaining sheet 14 is not torn off halfway.

  Next, a method for manufacturing a double soft capsule in the soft capsule manufacturing apparatus 1 of the present invention configured as described above will be described.

  As shown in FIG. 4, when the solid mixed solution 12 is supplied into the hopper 31, the solid mixed solution 12 in the hopper 31 is supplied to the supply tubes 34, 34,. To be supplied to the chemical solution filling unit 4. This supply timing control is performed as follows. In other words, the plunger pump 32 includes a plurality of plunger pins 321, 321,... That move forward and backward in the cylinder, and the valve that receives the pressure of the plunger pin 321 is attached to and detached from the seat surface. And the supply timing of the solid mixture 12 is controlled.

  Next, the solid mixed solution 12 supplied to the chemical supply unit 4 is linearly passed through the injection hole 411 of the tube assembly bottom, the liquid passage hole 431 of the slide valve, and the discharge hole 451 of the wedge, and from the discharge hole 451. Injected between the die rolls 51, 51.

  Thereafter, the ejected solid mixed liquid 12 is filled into the capsule film made of the gelatin sheet 13 by the capsule forming unit 5 as described above, and the double soft capsule 8 as shown in FIG. 8 is manufactured. It becomes.

  As described above, in the present invention, the solid mixed liquid 12 supplied from the hopper 31 to the chemical liquid filling unit 4 is jetted between the die rolls 51 and 51 without being cranked once in the chemical liquid filling unit 4. An injection hole 411, a liquid passage hole 431, and a discharge hole 451 were arranged, and the liquid passage was allowed to pass straight through them. As a result, the double soft capsule can be manufactured efficiently and satisfactorily without clogging the solid in the solid mixed solution in the chemical solution filling unit 4. In addition, by doing so, the return pad 46 and the dispersion plate 47 used in the conventional example are no longer necessary, so that the production cost of the soft capsule manufacturing apparatus can be reduced.

The perspective view which shows the structure of the chemical | medical solution filling part of the soft capsule manufacturing apparatus of this invention. The top view of the chemical | medical solution filling part. The side view of the chemical | medical solution filling part. The perspective view for demonstrating the structure of the conventional and the soft capsule manufacturing apparatus of this invention. The perspective view which shows the structure of the chemical | medical solution filling part of the conventional soft capsule manufacturing apparatus. The top view of the chemical | medical solution filling part shown in FIG. It is a figure of the chemical | medical solution filling part shown in FIG. 5, (a) is a side view, (b) is the elements on larger scale. Sectional drawing of a double soft capsule.

Explanation of symbols

1 Soft capsule manufacturing equipment 11 Solution (gelatin solution)
12 Solid mixture 13 Film sheet (gelatin sheet)
14 Remaining sheet 15 Double soft capsule 2 Sheet molding part 22 Spreader box 23 Molding drum 24 Hoisting roller 25 Sheet guide 26 Ribbon roller 3 Chemical liquid supply part 31 Hopper 32 Plunger pump 321 Plunger pin 33 Tube assembly top 34 Supply tube 35 Return Tube 4 Chemical solution filling portion 41B Tube assembly bottom 411 Injection hole 412 Joint 413 Mounting tool 414 Return joint 42B First pad 421B Pass hole 422B Return hole 43B Slide valve 431 Fluid hole 432 Fluid pipe 433 Lever 434B Return Hole 44 Second pad 441 Passing hole 45 Wedge 451 Discharge hole 452 Supply hole 453 Heater 5 Capsule molding part 51 Die roll 8 Double soft capsule 81 1 of the film 82 chemical 83 contained soft 831 second film 832 chemical R1, R2 mails solution route

Claims (2)

Two film sheets are transported between a pair of die rolls that are arranged opposite to each other and rotate reversely, and a solid mixed liquid obtained by mixing solids in the liquid filled in the hopper is fitted above the outer periphery of the die roll. The film is injected through the wedges, filled between the film sheets, the blades of the capsule pockets arranged on the outer peripheral surface of the die roll are meshed with each other, and the film sheet is heat-sealed and simultaneously demolded into a capsule shape. By this, a soft capsule manufacturing apparatus for manufacturing a soft capsule filled with the solid mixed solution in a capsule film,
A pump for sending out the solid mixture in the hopper;
A tube assembly top that distributes the solid mixture delivered from the pump into tubes;
A tube assembly bottom having a plurality of injection holes through which the solid mixed liquid is fed from the tube assembly top through the tube,
It is a hole through which the solid mixed solution fed from the tube assembly bottom passes, and has the same number of through holes as the injection hole, and can be operated to allow the solid mixed solution to pass through or return completely. A simple slide valve,
It is a wedge-shaped shape so as not to enter between the die rolls, and is a hole for discharging a solid mixed solution fed to the tip of the die roll through the liquid passing hole between the die rolls, and the number thereof is the number of the liquid passing holes. And a wedge having the same number of discharge holes,
The tube assembly bottom, the slide valve and the wedge are stacked and connected,
The soft capsule manufacturing apparatus, wherein the injection hole, the liquid passage hole, and the discharge hole communicate in a straight line. A pump for sending out a solid mixture obtained by mixing solids in a liquid filled in a hopper;
A tube assembly top that distributes the solid mixture delivered from the pump into tubes;
A tube assembly bottom having a plurality of injection holes through which the solid mixed liquid is fed from the tube assembly top through the tube,
It is a hole through which the solid mixed solution fed from the tube assembly bottom passes, and has the same number of through holes as the injection hole, and can be operated to allow the solid mixed solution to pass through or return completely. A simple slide valve,
A wedge-shaped wedge having a discharge hole, the number of which is the same as the number of the liquid flow holes, and a hole for discharging the solid mixed liquid fed through the liquid flow hole;
A pair of die rolls that rotate opposite to each other while the tip of the wedge enters between them, and
A soft capsule manufacturing method using a soft capsule manufacturing apparatus in which the tube assembly bottom, the slide valve, and the wedge are laminated and connected,
While transporting the two coating sheets between the die rolls, the solid mixed solution in the hopper is linearly passed through the tube assembly top through the injection hole, the liquid passage hole and the discharge hole. By spraying from the discharge holes, the film sheets are filled, the blades of the capsule pockets arranged on the outer peripheral surface of the die roll are meshed with each other, the film sheet is heat-sealed, and at the same time the mold is punched A soft capsule manufacturing method characterized by manufacturing a soft capsule filled with the above-mentioned solid mixed solution in a capsule film.

Images