JP4695866B2 - Plastic multi-chamber bag with small bag - Google Patents

Description

  The present invention relates to a resin-made multi-chamber bag with a sachet, and more particularly, to a resin-made multi-chamber bag with a sachet having a plurality of chambers including small chambers separated by a weak seal portion that can be easily peeled off during use.

  Resin bags and containers that are formed with weak seal parts that can be peeled manually between container walls or between container walls and other members, and used when used in the fields of food, pharmaceuticals, cosmetics, etc. Has been. For example, when multiple drugs are mixed and administered to a patient, such as when vitamins are mixed with physiological saline and injected or instilled into the patient, depending on the type of drug, the quality may deteriorate Therefore, there are multi-chamber infusion containers that can contain a plurality of drugs separately and mix them immediately before use, and many researches have been conducted on methods for forming such boundary portions.

  In particular, when an infusion solution containing amino acids, sugars, fats, and / or electrolytes is administered to a patient for a long period of time, a small amount of vitamin is mixed with the infusion solution. In particular, mixing vitamins consumed by sugar metabolism is essential for long-term administration. Vitamin is an unstable substance, so if it is mixed in the infusion solution at the time of manufacture, it will decompose over time during the sterilization process and storage period due to heat, light, the action of other components in the infusion solution, etc. It has been known. Therefore, conventionally, it was mixed in an infusion container using a syringe or the like at the time of administration. However, since the amount of vitamins to be mixed is extremely diverse and in a very small amount, and maintenance of sterility is essential, the mixing operation at the time of administration takes time.

Therefore, a medicine such as a vitamin solution is sealed in the sachet, and the sachet is sealed together with the infusion solution in the infusion container, and the sachet is sealed with a weak seal that can be easily peeled off. By pressing, the weak seal part is peeled off so that drugs such as vitamin solutions can be added to the infusion, and the sachet is welded together at the periphery of the infusion container to limit the sachet floating in the container. In this case, there has been proposed one that is fixed (see, for example, Patent Document 1). However, in such a method, since one end of the sachet must be positioned at the peripheral edge of the infusion container at the time of manufacture, it takes time and labor for positioning and welding, and there is a problem that the work efficiency is hindered. It was. Further, when the sachet is thin, there is a problem that a sealing failure is likely to occur at the time of welding. In order to solve such a problem, a small partition portion that can accommodate the sachet and restrict its movement is formed in the container itself by partially welding the opposing bag inner wall surfaces of the container itself. In addition, there is a non-welded portion through which the liquid can flow at the boundary portion of the small compartment portion, and the small compartment portion is in contact with the peripheral weld portion formed by welding the inner wall surfaces of the bags facing each other at the periphery of the bag-like container itself. A bag-like container characterized by being provided has been developed (see, for example, Patent Document 2), and further, the chemical solution storage pouch is opened in conjunction with the pressing of the storage chamber or the accompanying opening of the partition of the storage chamber ring A chemical solution container with a chemical solution containing sachet (for example, see Patent Document 3) is disclosed.
However, since all of the sachets filled with vitamins or the like are inserted into the infusion solution from the outside and enclosed, it is impossible to completely remove foreign substances adhering to the outer surface of the sachets. In addition, there is a problem that, for example, it is easy to forget to check whether the sachet is completely opened during use.
JP-A-3-289478 JP 2001-37847 A JP 2003-62038 A

  In view of the above problems, the present invention accommodates three or more solutions without enclosing a sachet in the infusion solution, and can be easily mixed at the time of use, and the solution in the sachet can be easily confirmed, and the sachet is forgotten to be opened. An object of the present invention is to provide a resin multi-chamber bag with a small bag.

  As a result of intensive studies to solve the above problems, the present inventor has provided a small-capacity small chamber formed in a dimple shape in the middle portion of the weak seal portion in the multi-chamber bag divided by the weak seal portion. The present invention has been completed by finding that it is possible to produce a resin-made multi-chamber bag with a sachet that can completely prevent foreign matter from being inserted without the need to insert a sachet, and that can not forget to open the sachet.

That is, according to the first aspect of the present invention, in the multi-chamber bag having a plurality of chambers in which the first chemical solution storage chamber and the second chemical solution storage chamber are separated by the weak seal portion, the weak seal portion A small-capacity small chamber is provided in the middle portion to store the third chemical liquid molded in the dimple shape, and the thickness of the small chamber is 50 to 70% of the resin raw material constituting the multi-chamber bag. Thus, when the first or second storage chamber is pressed from the outside, the weak seal part is peeled off, and the third chemical liquid is easily mixed with the first chemical liquid and the second chemical liquid. A multi-bag bag made of resin is provided.

  According to a second aspect of the present invention, there is provided a resin-made multi-chamber bag with a small bag according to the first aspect, wherein the small-capacity chamber formed into a dimple shape is formed by vacuum forming. Is done.

  Since the resin multi-chamber bag with a sachet of the present invention can be molded without enclosing the sachet in the infusion solution, foreign substances from the outside can be completely eliminated and can be easily mixed at the time of use, and the liquid in the sachet can be confirmed. It is a multi-chamber bag that is easy and does not forget to open the sachet.

  The resin multi-chamber bag with a sachet according to the present invention forms a bag portion by strongly sealing the resin film seal layers with each other at the outer peripheral portion, and at the same time providing a weak seal portion inside the bag portion. In a resin-made multi-chamber bag that can be divided into a plurality of chambers, and only the weak seal portion is peeled off and combined with each other during use, a small chamber is provided at the center of the weak seal portion. Hereinafter, the resin multi-chamber bag with a sachet according to the present invention will be described in detail with reference to the drawings.

The resin-made multi-chamber bag with a sachet according to the present invention is formed by using a resin film having flexibility. A description will be given by taking as an example the resin-made multi-chamber bag with small bags shown in FIGS. FIG. 1 is a front view showing an example of a resin-made multi-chamber bag with a sachet according to the present invention. 2 is a cross-sectional view in the XX ′ direction, and FIG. 3 is a cross-sectional view in the YY ′ direction.
1 to 3, the multi-chamber bag 1 is provided with an easily peelable seal portion 13 that separates the storage chamber 2 for the first chemical solution, the storage chamber 3 for the second chemical solution, and the storage chamber 2 and the storage chamber 3. In addition, a small chamber 4 is provided at the center of the easy-peeling seal portion 13 for storing a small amount of chemical solution or the like formed in a dimple shape. The multi-chamber bag 1 is formed by strongly sealing the surface films 11 and 12 at the upper part 14, the lower part 15 and the side parts 16 and 17 at the peripheral part. The outlet 19 is provided and is strongly sealed.
In addition, 13 'shows a weak seal state and 16', 17 'shows a strong seal state.

The resin multi-chamber bag with a sachet of the present invention, when in use, when the storage chamber 2 or the storage chamber 3 is pressed from the outside, the easy peeling seal portion 13 is easily peeled off, and the first chemical solution in the storage chamber 2 and the like. And the second chemical solution in the storage chamber 3 are mixed. Moreover, since the width | variety of the liquid which exists in the small chamber 4 is narrower than the width | variety of the easy peel seal part 13 whole in the easy peel seal part, when the said storage chamber 2 or 3 is pressed, 13a, 13b is the first. Since it peels off and is completely mixed with the liquid in the storage chamber 2 or 3, there is an advantage that a problem such as forgetting to open is not caused.
As can be seen from FIGS. 2 and 3, the small chamber 4 is provided so as to protrude at the center of the easy-peeling seal portion 13, so that it is easy to confirm the presence or absence of the liquid present therein.
The size of the small chamber is appropriately determined depending on the amount of liquid present in the small chamber, but the widths of 13a and 13b are preferably 30 to 50% of the entire width of the easily peelable seal portion 13. Moreover, it is preferable that length is 20 to 40% of the length of the easy peel seal part 13 whole.
Further, the wall thickness of the small chamber is set to 50 to 70% of the resin raw material constituting the multi-chamber bag. Since a small amount of liquid is present in the small chamber than the chemical liquid stored in the storage chambers 2 and 3, it is preferable that the thickness is slightly thinner in order to confirm the contents.

The production of the resin-made multi-chamber bag with a small bag of the present invention is not particularly limited as long as the small chamber can be provided in the easily peelable seal portion, and a conventionally known method for producing a multi-chamber bag can be applied. For example, in the case of using a plate-like film, a dimple-like bulge is provided in advance by vacuum forming or the like on the portion corresponding to the easily peelable seal portion of one of the two films, and the two films are stacked. Then, a weak seal is formed so as to form a strong seal and a small chamber to form a bag.
In the case of a cylindrical film, it is used after being cut to an appropriate length, but in the process before film cooling and hardening at the time of film formation, it is used as a robot arm that operates in synchronization with the flow of the tube in part of the bubble. By attaching the attached silicone rubber suction pad and forming dimple-like recesses by vacuum forming, the dimple is continuously formed at the locations corresponding to the easily peelable seals to form bulges. It is possible to form a small chamber by weakly sealing only the part to be performed.

  In order to inject a chemical solution or the like into each of the chambered resin multi-chamber bags of the present invention, the upper 14, lower 15 and one side 17 in FIG. The storage chamber 2 and the storage chamber 3 are simultaneously injected from the same side with the chemical solution 2 and the second chemical solution, and finally the remaining side part 16 is strongly sealed, thereby shortening the process and manufacturing a multi-chamber bag containing the medicine. be able to. In addition, for the injection of the liquid into the small chamber 4, a passage leading to the small chamber is provided in the center of the weak seal portion on the unsealing side 16 (for example, a dotted line portion), and at the same time the chemical solution 1 and the chemical solution 2 are injected, the small chamber 4 from the same side. Therefore, the process can be shortened in time and an economical method can be obtained.

  The resin-made multi-chamber bag with a sachet of the present invention is formed from a synthetic resin film. The synthetic resin film may be a single layer film or a multilayer film, but is preferably a laminated film having at least an outer layer of a polyolefin resin and a sealant layer.

  The outer layer can be used without particular limitation as long as it is a polyolefin-based resin having transparency and flexibility. It must be durable against temperature conditions such as hot water sterilization and impact, and as the polyolefin resin having such characteristics, resins such as high-density polyethylene and polypropylene are preferable. The thickness of the outer layer is preferably 50 to 145 μm, more preferably 50 to 80 μm. Further, the outer layer is preferably in the range of 25 to 60%, preferably 20 to 45% of the total thickness of the laminated film. When it exceeds 60%, the entire bag becomes hard, and for example, when used as a medical bag, a uniform drainage flow rate cannot be obtained.

  The sealing layer is a layer that forms a weak seal portion that seals the outer peripheral portion of the entire bag with a strong seal of strong heat fusion, and at the same time can be easily peeled off by a weak seal of weak heat fusion and constitutes a plurality of chambers. It is. As a preferable sealing layer, there can be used at least two types of resin mixture layers of polyethylene resins having different melting points of 20 ° C. or higher, a polypropylene resin composition in which a modifier is blended with polypropylene, and the like.

  In the polyethylene resin constituting the resin mixture layer, examples of the high melting point polyethylene resin include high density polyethylene, medium density polyethylene, linear low density polyethylene, low density polyethylene and the like. Polyethylene, particularly metallocene catalyst linear low density polyethylene is preferred. Examples of the low melting point polyethylene-based resin include ethylene / α-olefin copolymers using α-olefins such as propylene and butene-1 as comonomers. Among these, ethylene-butene copolymer rubbers, Ethylene-propylene copolymer rubber and the like are preferable.

Due to the difference in melting point in the polyethylene resin mixture of 20 ° C or more, the strong seal (high temperature seal) melts the resin mixture completely to increase the seal strength, and does not peel easily and weakly seal (low temperature seal). Then, a melted part and an unmelted part exist and easy peelability is imparted. If the temperature difference between the melting points is too small, the conditions for forming a weak seal portion by welding in a peelable manner become narrow.
In addition, melting | fusing point of polyethylene-type resin is melting | fusing point measured by DSC.

  The mixing ratio of the high melting point polyethylene resin and the low melting point polyethylene resin is preferably 5 to 40 parts by weight, more preferably 10 to 25 parts by weight with respect to 100 parts by weight of the high melting point resin. is there. When the low melting point resin is less than 5 parts by weight, it becomes difficult to form a peelable weak seal part, and when it exceeds 40 parts by weight, it becomes difficult to form a peelable weak seal part and the thermal deformation temperature is lowered. When used as a bag, the bag is deformed by autoclaving. Moreover, the thickness of the sealing layer is preferably 10 to 50 μm, more preferably 25 to 35 μm. The sealing layer is preferably in the range of 15 to 38%, preferably 15 to 25% of the total thickness of the laminated film.

When polypropylene is used for the inner layer, polypropylene having a melting point of 20 ° C. or more lower than that of the polypropylene used for the outer layer is preferable in order to obtain effects such as flexibility, and in particular, propylene-ethylene random copolymer and metallocene catalyst. Polymerized propylene / α-olefin copolymer and the like are preferable.
The modifier added to the polypropylene is not particularly limited as long as it is a resin having a low melting point, an amorphous property, and excellent compatibility with polypropylene, but an ethylene / α-olefin copolymer rubber is preferable. Examples of the α-olefin in the ethylene / α-olefin copolymer include propylene and butene-1, and specific copolymer rubbers include ethylene-butene copolymer rubber and ethylene-propylene copolymer. Rubber etc. are mentioned. By blending these rubbers with polypropylene, a low-temperature seal and a high-temperature seal are possible in the heat-sealing of the seal layers. The blending ratio of the polypropylene and the modifier in the polypropylene resin composition is 55 to 95% by weight of polypropylene, preferably 65 to 95% by weight, and 5 to 45% by weight of the modifier, preferably 5 to 35% by weight. When the proportion of polypropylene is less than 55% by weight (when the modifier exceeds 45% by weight), it becomes difficult to form a weakly sealable part that can be peeled off, and the heat deformation temperature is lowered, so that it is used as a medical bag. In this case, the bag is easily deformed by high-pressure steam sterilization, and if it exceeds 95% by weight (the modifying agent is less than 5% by weight), it becomes difficult to form a weak seal portion that can be peeled off.

  Moreover, the thickness of an inner layer becomes like this. Preferably it is 30-80 micrometers, More preferably, it is 40-80 micrometers. The inner layer is preferably in the range of 5 to 30%, preferably 15 to 30% of the total thickness of the laminated film.

  The polyolefin-based laminated film can be manufactured by applying a known manufacturing method such as a water-cooled or air-cooled coextrusion inflation method, a coextrusion T-die method, a lamination method, and in particular, can be coextruded by a coextrusion method. Preferably, a resin layer having a substantially uniform thickness is molded and molding efficiency is increased. In addition, since deterioration of the resin during molding is small, characteristics of each layer are maintained, and a material having good transparency and flexibility can be obtained. The obtained laminated film may be a tube shape or a sheet shape. The temperature conditions in manufacture are 160-250 degreeC, More preferably, it is 165-230 degreeC. It is desirable to reduce the difference in the melt flow rate (MFR) of the resin used for the resin constituting each layer in order to maintain a substantially uniform layer thickness and moldability. Furthermore, the laminated film used in the present invention may be coextruded by dividing one layer into two or more layers, whereby the transparency of the entire film can be further improved.

  Moreover, when the chemical | medical solution with which the resin multi-chamber bag with a sachet is easy to deteriorate with gas, such as oxygen, and light, what has gas barrier property and light-shielding property may be used as a resin film. .

Here, the material enclosed in the storage chamber 2 and the storage chamber 3 is not particularly limited. For example, the drug may be any of a powder, a liquid, or a solid. Examples of the powder include an antibiotic and an anticancer agent. , Steroid agents, thrombolytic agents or vitamin agents, etc., hygroscopic, oxidizable and heat-denaturing substances, and liquid agents include, for example, physiological saline, glucose solution, distilled water for injection, electrolyte solution, amino acid Liquid, fat emulsion and the like.
The liquid stored in the small chamber 4 is generally used as an unstable chemical solution, a chemical solution that cannot be stored in a mixed state with other chemical solutions stored in the storage chamber 2 and the storage chamber 3, an amount used for infusion, etc. It is used for containing a small amount of a chemical solution, and specifically contains a vitamin, a trace element, etc. for mixing with a high calorie infusion (IVH).

The present invention will be described in detail based on examples, but the present invention is not limited to these examples.
Example 1
Using a water-cooled coextrusion inflation molding machine, high-density polyethylene (HDPE: Nippon Polychem HY540, melting point 135 ° C.) as an outer layer, metallocene catalyst-based linear low-density polyethylene (mLLDPE: Kernel KF271, Nippon Polychem) as an intermediate layer, Melting point: 102 ° C.) 100 parts by weight of metallocene catalyst-based linear low density polyethylene (mLLDPE: Kernel KF271 manufactured by Nippon Polychem, melting point: 102 ° C.) and ethylene-butene copolymer rubber (EBR: Tuffer manufactured by Mitsui Chemicals) as the sealing layer (A, melting point less than 50 ° C.) Using a mixture of 20 parts by weight, a laminated film having an outer layer of 140 μm, an intermediate layer of 75 μm, a seal layer of 75 μm, and a folding diameter of 250 mm was obtained. In the previous process of cooling and curing the tube-shaped laminated film, a silicon rubber suction pad attached to a robot arm that operates in synchronization with the flow of the tube is in close contact with a part of the bubble, and the size is 3.5 cm deep by vacuum molding. A dimple-like recess was provided. The laminated layers of the laminated film were overlapped with each other, the peripheral edge portion was strongly sealed, the center seal was weakly sealed, and a multi-chamber bag as shown in FIG. 1 was produced. The storage chamber 2 was filled with 20 cc of colored liquid, the storage chamber 3 was filled with 400 ml of 5% glucose solution, and the small chamber 4 was filled with 300 cc of 12% amino acid solution.
After filling, the container was sterilized with high pressure steam, and after cooling, the storage chamber 3 was pressed with both hands. As a result, the storage chamber 2-the small chamber 4-the storage chamber 3 communicated at once, and the liquids in each chamber were mixed.

(Example 2)
Using an extrusion molding machine equipped with a T-die, a polypropylene resin composition (a mixture of EA8: 90% by weight of Nippon Polychem Co., Ltd. and Kuraray Hibler 7125: 10% by weight) is used as the outer layer, 75 μm, and the polypropylene resin composition is used as the inner layer. Using a product (EA8: 50% by weight manufactured by Nippon Polychem Co., Ltd. and Kuraray Hibler 7125: 50% by weight), a tubular laminated film having an outer layer of 75 μm, an inner layer of 225 μm, and a fold diameter of 250 mm was formed, and the depth was 4 cm A dimple-like recess was provided using a circular silicon rubber suction pad. From this laminated film, a multi-chamber bag having small chambers was produced in the same manner as in Example 1.
After each container was filled with a liquid in the same manner as in Example 1, sterilized by high-pressure steam, cooled, and pressed the storage room 3 with both hands, the storage room 2-the small room 4-the storage room 3 communicated at once. The liquid was mixed.

  Since the resin multi-chamber bag with a sachet of the present invention can be molded without enclosing the sachet in the infusion solution, foreign substances from the outside can be completely eliminated and can be easily mixed at the time of use, and the liquid in the sachet can be confirmed. It is easy and it is a multi-chamber bag that does not forget to open the sachet, so it can be used as a medical multi-chamber bag that can store chemicals that cause chemical changes when mixed at the same time and can be mixed or dissolved at the time of use. it can.

It is a figure which shows an example of the polyolefin resin-made multi-chamber bag of this invention. FIG. 2 is a cross-sectional view in the X-X ′ direction of FIG. 1. FIG. 2 is a cross-sectional view in the Y-Y ′ direction of FIG. 1.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Multi-chamber bag with a sachet 2, 3 Chemical solution storage chamber 4 Small chamber 11, 12 Surface film 13 Easily peelable seal part 14, 15, 16, 17 Periphery strong seal part 18 Inlet 19 Outlet

Claims (2)

In the multi-chamber bag having a plurality of chambers in which the first chemical solution storage chamber and the second chemical solution storage chamber are separated by a weak seal portion,
A small-capacity chamber is provided in the middle portion of the weak seal portion to store the third chemical liquid formed in a dimple shape, and the wall thickness of the chamber is 50 to 50% of that of the original resin constituting the multi-chamber bag. By setting the ratio to 70%, when the first or second storage chamber is pressed from the outside, the weak seal part is peeled off, and the third chemical liquid is easily mixed with the first chemical liquid and the second chemical liquid. Characteristic plastic multi-chamber bag with small bag.   2. The resin-made multi-chamber bag with a sachet according to claim 1, wherein the small chamber having a small capacity formed in a dimple shape is formed by vacuum molding.

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