JP4700313B2 - Composition comprising proanthocyanidins and sphingolipids - Google Patents

Description

  The present invention is effective in preventing skin dullness, preventing rough skin, improving skin color such as spots, and preventing wrinkles, and can be used regularly as a food and can be ingested continuously. The present invention relates to a supplement containing a factor that causes anxiety, a composition containing proanthocyanidins and sphingolipids suitable for so-called supplements, and a food that is processed easily.

  The desire for health is a place where human beings are equally seeking regardless of whether it is east or west, but in recent years there have been many supplements on the market that have become particularly strong and expect various effects. Consumers are looking for something that is as effective as possible, and suppliers are striving to meet this demand.

  In such a situation, one of the strong demands is skin health. There is a strong desire to maintain the health of skin, such as firm skin, skin with little wrinkles, youthful skin, and skin with few spots.

  In addition to aging, the amount of ultraviolet rays on the surface due to changes in the global environment, various skin disorders caused by these, sunburn spots, wrinkles, sagging, etc. are generated, making you feel old. On the one hand, while trying to deepen the way of life as a person, on the one hand, efforts are being made to maintain youthfulness that does not make you feel any aging at all, rather than leaving it to work. Is real.

  In such a situation, various attempts have been made. For example, foods containing proanthocyanidins are provided as foods for antioxidant and anti-inflammatory. Proanthocyanidins are flavonoid compounds, and are a general term for a group of compounds in which two or more polycondensation units are mainly composed of flavan-3-ol and / or flavan-3,4-diol. .

  A polycondensation product having a polymerization degree of 2 to 4 and comprising flavan-3-ol and / or flavan-3,4-diol as a structural unit is called an oligomeric proanthocyanidin (OPC), particularly among proanthocyanidins. As it is said that the antioxidant action is so strong that it is said to be 20 times that of vitamin C and 50 times that of vitamin E, it is used in various modes for eliminating superoxide, which is regarded as an aging promoting factor.

  OPC is also known to have functions such as anti-oxidation, blood vessel strength, elasticity recovery, blood cholesterol and LDL reduction, blood pressure reduction for hypertension, and cholesterol adhesion prevention. Because of these functions, they are used to protect blood vessels, improve blood flow, and prevent arteriosclerosis.

However, since proanthocyanidins have strong astringency, bitterness, and astringency, they are resistant to ingestion as they are, and attempts have been made to improve them.
For example, a proanthocyanidin preparation that has been mixed and dissolved with a starch hydrolyzate having a molecular weight of 1000 to 2000 and then dried by a method such as spray drying is described (Patent Document 1).

  Next, sphingolipid is a general term for a series of compounds containing in the molecule an amide bond between a sphingosine or a long-chain amino alcohol having a structure similar to this and a fatty acid such as a long-chain fatty acid. A group of compounds called ceramides are widely known as representative compounds of sphingolipids.

  Sphingolipid attracts attention as a substance having functions such as skin moisturization, moisture regulation, elasticity retention, collagen protection, and vitamin C and E stabilization, and as a functional material in the field of cosmetics and foods. Use is planned. Recently, it has been found that an antigenic substance is suppressed or prevented from entering the body from the outside world and is effective in suppressing atopic dermatitis, and is being developed as a pharmaceutical.

  Health food containing ceramide (Patent Document 2), cosmetic material containing glycolipid, cosmetic and food (Patent Document 3), collagenase inhibitor, moisturizing Agents and cosmetics and foods containing the same (Patent Document 4) are known.

About the extraction method of sphingolipid, it describes in well-known literature etc. (patent documents 5, patent documents 3 , patent documents 7, and patent documents 8), and moisturizes, beautiful skin, rough skin by ingesting sphingolipid orally, for example. It has been reported that there are cosmetic effects such as prevention and wrinkle prevention (see Non-Patent Document 1 and Non-Patent Document 2).

  Sphingolipids have a peculiar taste to lipids, and when they are ingested alone, the bad aftertaste remains in the mouth forever. Yes.

  To achieve this solution, sphingolipids are added to agar, casein, dextrin, cyclodextrin, gelatin, pectin, starch, cellulose, carboxymethylcellulose, carrageenan, alginic acid or salts thereof, protein, calcined or uncalcined calcium, calcium carbonate, Although powdered by spray drying method and freeze-drying method with silicon etc. is put on the market, it is inevitable that the bad aftertaste remains in the mouth forever during ingestion.

Under such circumstances, despite the fact that they are proanthocyanidins and sphingolipids that have valuable functions, it is mysterious that the combination of both is not known in any form. is there.
JP 2001-199886 A JP-A-11-113530 JP-A-11-92781 JP 2000-26228 A Special table hei 6-507653 JP-A-11-92781 JP 2001-97983 A JP 2003-3192 A Fragrance Journal Vol. 23, no. 1,81-89,1995 New drugs and clinics Vol. 5, no. 9, 62 (890) to 72 (900), 2002

  In the situation described above, the present invention provides a composition comprising proanthocyanidins and sphingolipids having a taste driven by improvement in taste such as aftertaste, continuation of the composition, and temptation to regular consumption. It is to provide.

  The composition or food according to the present invention can be obtained by mixing proanthocyanidins and sphingolipids or a premix containing these, and can be ingested as food in an appropriate form. Therefore, it is provided by processing with appropriate excipients.

That is, the present invention
(1) A composition comprising proanthocyanidins and sphingolipids,
(2) The composition according to the above (1), wherein the ratio of proanthocyanidins and sphingolipids is a ratio of 3.7: 1 to 150: 1 by weight ratio,
(3) The composition according to the above (1) or (2), wherein the ratio of proanthocyanidins and sphingolipids is a ratio of 8.3: 1 to 100: 1 by weight ratio,
(4) The composition according to any one of (1) to (3) above, wherein the proanthocyanidin is a condensation polymer of flavan-3-ol and / or flavan-3,4-diol,
(5) The composition according to the above (4), wherein the polymerization degree of the condensation product of flavan-3-ol and / or flavan-3,4-diol is 2 to 4,
(6) The composition according to any one of (1) to (5) above, wherein the proanthocyanidins are derived from a pine bark extract,
(7) The composition according to any one of (1) to (5), wherein the sphingolipid is a substance containing a long-chain fatty acid amide structure of sphingosine,
(8) The composition according to any one of (1) to (7), wherein the proanthocyanidin is a condensation polymer of flavan-3-ol and / or flavan-3,4-diol, and the sphingolipid is ceramide. object,
(9) The composition according to (8), wherein the degree of polymerization of the condensation polymer is 2 to 4,
(10) A food comprising the composition according to any one of (1) to (9),
(11) The food according to (10), wherein the shape is a tablet,
(12) The food according to (10) or (11), which has a skin beautifying action,
(13) A food containing the composition according to the above (1) to (9), having a skin beautifying action, and having a display indicating that it is used to obtain the skin beautifying action,
(14) The food according to (1), (2) or (13), wherein the skin beautifying action is prevention of dull skin, prevention of rough skin, improvement of skin color, or prevention of wrinkles, and (15) said (1 ) To (9) a skin quality improving agent comprising the composition according to any one of
It is about.

  According to the present invention, the peculiar bitterness, astringency, and astringent taste of proanthocyanidins and the peculiar bad aftertaste of sphingolipids change depending on the mixture of the two, resulting in a gustatory continuation. A composition that does not feel uncomfortable to use regularly, and that allows the user to feel the efficacy of proanthocyanidins and sphingolipids after ingestion due to a new taste born from mixing the two. Goods, foods or medicines can be obtained.

  The proanthocyanidins used in the present invention are constituted by a group of compounds generically called flavonoids, and mainly contain flavan-3-ol and / or flavan-3,4-diol as structural units. A group of compounds including a polycondensation polymer. Therefore, in addition to these, for example, flavones, flavonols, flavonanols, isoflavones and the like may be included, and those including these are also referred to as proanthocyanidins in the present invention and are the subject of the present invention. is there.

  Proanthocyanidins are also called the seventh nutrient after dietary fiber, and for the human body, they must not be taken in other than ingestion. Sometimes they are also called polyphenols. As mentioned above, they have a very strong antioxidant power. It is what.

  Proanthocyanidins used in the present invention are bark such as pine, persimmon, wild peach, grape, blueberry, raspberry, cranberry, strawberry, avocado, false acacia, cowberry fruit or seed, barley, wheat, soybean, black soybean, It is said that it is abundant in cacao, red beans, tomato husks, peanut skins, ginkgo biloba, West African cola nuts, Peruvian lanania roots, Japanese green tea. These are said to be rich in oligomeric proanthocyanidins (OPC) mainly composed of the aforementioned flavan-3-ols and / or flavan-3,4-diols. These plant extracts are processed on the market in powder or with additives.

  In the present invention, as the proanthocyanidins, food raw materials such as bark, fruit or seed crushed material rich in OPC, or extracts thereof can be used. In particular, it is preferable to use an extract of pine bark. Since pine bark is rich in OPC among proanthocyanidins, it is preferably used as a raw material for proanthocyanidins in the present invention.

Hereinafter, a method for preparing proanthocyanidins will be described using an example of an extract of pine bark containing OPC.
Pine bark extracts include Pinus Martina, larch, Japanese black pine, Japanese red pine, Japanese pine, Japanese pine, Korean pine, Japanese pine, Ryukyu pine, Utsukushima, Japanese pine, Japanese pine An extract of the bark of a plant belonging to is preferably used. Among them, a pine bark extract of French maritime pine (Pinus Martina) is preferable.
French coastal pine is a marine pine that grows on the Atlantic coast of southern France. This French coastal pine bark contains proanthocyanidins, organic acids, and other physiologically active ingredients, and it is known that proanthocyanidins, which are the main ingredients, have a strong antioxidant action to remove active oxygen. Yes.

  The pine bark extract is obtained by extracting the pine bark with water or an organic solvent. When water is used, warm water or hot water is used. As an organic solvent used for extraction, an organic solvent that is acceptable for the production of food or drugs is used. For example, methanol, ethanol, 1-propanol, 2-propanol, 1-butanol, 2-butanol, acetone, hexane, cyclohexane , Propylene glycol, hydrous ethanol, hydrous propylene glycol, ethyl methyl ketone, glycerin, methyl acetate, ethyl acetate, diethyl ether, dichloromethane, edible oils and fats, 1,1,1,2-tetrafluoroethane, and 1,1,2- Trichloroethene is mentioned. These water and organic solvent may be used alone or in combination. In particular, hot water, hydrous ethanol, and hydrous propylene glycol are preferably used.

A method for extracting proanthocyanidins from pine bark is not particularly limited, and for example, a warm extraction method, a supercritical fluid extraction method, or the like is used.
The supercritical fluid extraction method is a method of performing extraction using a supercritical fluid that is a fluid that exceeds the critical point (critical temperature, critical pressure) of a gas-liquid substance. As the supercritical fluid, carbon dioxide, ethylene, propane, nitrous oxide (laughing gas) or the like is used, and carbon dioxide is preferably used.
The supercritical fluid extraction method includes an extraction step of extracting a target component with a supercritical fluid and a separation step of separating the target component and the supercritical fluid. In the separation step, any one of extraction separation by pressure change, extraction separation by temperature change, or extraction separation using an adsorbent / absorbent may be performed.

Moreover, you may perform supercritical fluid extraction by the entrainer addition method. In this method, 2 to 20 W of ethanol, propanol, n-hexane, acetone, toluene, other aliphatic lower alcohols, aliphatic hydrocarbons, aromatic hydrocarbons, or ketones are added to the supercritical fluid. / V% is added, and supercritical fluid extraction is performed with the obtained extraction fluid, thereby dramatically increasing the solubility of the target substance such as OPC and catechins in the extraction fluid, or selection of separation It is a method for enhancing the sex, and a method for efficiently obtaining a pine bark extract.
Since the supercritical fluid extraction method can be operated at a relatively low temperature, it can be applied to substances that are altered or decomposed at high temperatures; the advantage that the extraction fluid does not remain; and the recycling of the solvent is possible. There is an advantage that the process can be omitted and the process becomes simple.

Extraction from pine bark may be performed by a liquid carbon dioxide batch method, a liquid carbon dioxide reflux method, a supercritical carbon dioxide reflux method, or the like, in addition to the above method.
Extraction from pine bark may be combined with a plurality of extraction methods. By combining a plurality of extraction methods, it becomes possible to obtain pine bark extracts having various compositions.

  Therefore, the proanthocyanidins, particularly OPCs used in the present invention, can be suitably used those that are provided on the market as extracts from the above-mentioned plants. For example, products such as trade name Flavangenol (manufactured by Toyo Shinyaku Co., Ltd.) and trade name Pycnogenol (manufactured by Tradepia Co., Ltd.) can be mentioned.

The sphingolipid referred to in the present invention is a group of compounds (referred to as ceramide) in which a higher amino alcohol having 16 to 22 carbon atoms, mainly 18 carbon atoms, and a fatty acid are amide-bonded, which is called sphingosine. .
The fatty acid may be either a saturated fatty acid or an unsaturated fatty acid, and various kinds of fatty acids exist depending on the length of the fatty acid chain.
The present invention is not intended only for those having a specific chain length, but is intended for all what are called sphingolipids.

  The chain length of the fatty acid to be given to the amide bond is not particularly limited, but may be a straight chain or branched chain having 8 to 26 carbon atoms, preferably 14 to 18 carbon atoms, and one or more hydroxyl groups May be substituted.

  In addition, since the higher amino alcohol constituting the sphingolipid has two hydroxyl groups, one or several kinds of sugar, phosphoric acid, sialic acid, choline, ethanolamine, etc. may be bonded to these. A compound to which is bound can also be used. Glucose, mannose, galactose, or the like may be bonded to the hydroxyl group as a sugar, and it is particularly preferable that 1 to 4 glucoses are bonded.

The ceramide referred to in the present invention includes glucosylceramide in which a sugar (mainly galactose) is bonded to a glycosyl ether in sphingolipid.
The sphingolipid used in the present invention is obtained by extracting from seeds such as rice, soybean, corn, safflower, sesame, rape, sunflower, oil palm, coconut palm, olive, cotton, wheat and the like containing this. It can be preferably used. The extraction method has already been described in the above-mentioned patent documents.

  Extracted sphingolipids are agar, casein, dextrin, cyclic oligosaccharide, gelatin, pectin, starch, cellulose, carboxymethylcellulose, carboxymethylcellulose calcium, carrageenan, alginic acid or its salt, protein, calcium carbonate, silicon dioxide, baking Alternatively, since it is solidified and powdered by a method such as spray drying or freeze drying together with uncalcined calcium or the like, it is provided on the market, so that it can be used. Therefore, the products obtained in these markets may not necessarily be 100% sphingolipids. For example, it is commercially available with a content of 3 w / w% to 6 w / w%.

  Examples of sphingolipids that can be obtained from the market include, for example, trade name: Orizaceramide-P (produced by Oriza Oil Chemical Co., Ltd.), trade name: Konjac Ceramide (powder type) (produced by Unitika Ltd.), trade name: Nissan N-ceramide ( Nippon Oil & Fats Co., Ltd.), Nipcerceramide RPS (Nippon Flour Mills Co., Ltd.) and the like.

  The composition according to the present invention comprises proanthocyanidins and sphingolipids, but it is possible to add other appropriate additives without any problem. It is the target.

  In the composition according to the present invention, the ratio of proanthocyanidins to sphingolipids is 3.7: 1 to 150: 1, preferably 8.3: 1 to 100: 1, by weight. This ratio is an important factor from the relationship with the taste of the composition according to the present invention. In the case of foods and health foods that are intended for supplementation, it is an essential requirement that they must be continuously ingested, so the taste during intake is extremely important. This is because it will be forgotten if it is not just the sweetness, acidity, hotness, bitterness, and satisfaction that can be expected from the effect.

It is important to remember from the taste that the so-called taste is unforgettable and that you want to try it again. For example, if the bitterness of bitter gourd disappears, it can be said that the charm of eating disappears.
Therefore, the taste of the material is not erased or changed, but is left as it is. As a result, an effect is expected, and it is attracted by the taste, and it is possible to cause a desire to continue to ingest. From such a meaning, in the present invention, the expression of effectiveness is used.

  As described above, when using a commercially available product, various additives may be included. Further, even when these products are used, it is possible to appropriately use additives without any problem. Including such cases, as additives, for example, vitamins (such as vitamin C), lactose, cellulose, sucrose, glucose, corn starch, potato starch, wheat starch, dextrin, sorbitol, mannitol and the like are usually used. There are some things.

  Besides these, lubricants such as magnesium stearate, calcium stearate, sucrose fatty acid ester, talc, binders such as hydroxypropylcellulose, hydroxypropylmethylcellulose, gelatin, starch paste, and disintegrants such as carboxymethylcellulose calcium In addition, those on the market as colorants and flavoring agents can be used as appropriate.

The composition according to the present invention can be produced by mixing proanthocyanidins extracted from plants and sphingolipids, optionally using appropriate additives. Alternatively, it can be produced by processing the extracted proanthocyanidins and sphingolipids and mixing the above-mentioned products available on the market, optionally using additives.
The compounding amount of proanthocyanidins in the composition may be determined on the basis that the intake of proanthocyanidins is 10 mg to 300 mg, preferably 40 mg to 200 mg per day per adult.

  As the method for mixing, those having a stirring and mixing function such as a commonly used V-type mixer, fluidized bed granulator, kneader mixer and the like can be used.

  The composition according to the present invention may be any composition in which proanthocyanidins and sphingolipids are uniformly mixed, and may be granulated using a binder or simply mixed. .

The form of the food or pharmaceutical product according to the present invention is not particularly limited, and any form from jelly, yogurt, noodle products, breads to tablets such as pharmaceuticals, capsules, granules, troches, etc. Although it may be in the form of a tablet, the tablet form is preferred from the viewpoint of convenience of carrying, ease of ingestion by chewing or the like, and ease of handling. Such a tablet can be produced in accordance with a method commonly used in the field of food and medicine, for example, a method described in the Japanese Pharmacopoeia, and can be colored appropriately by coating or the like.
For example, when manufacturing a tablet, the above-mentioned mixed composition can be compression-molded by a conventional method using a rotary tableting machine or the like.

Evaluation of the composition obtained by this invention employ | adopts the method by the sensory test by five expert panelists. The paneler contains 0.3 g of the proposed powder directly in the mouth, disperses it in the oral cavity with saliva, confirms the taste, and performs according to the following criteria.
4 points: Astringent taste, astringent taste, aftertaste, etc. are inferior, but have high efficacy.
3 points: Astringency, astringency, and aftertaste are slightly inferior, but have a sense of efficacy.
2 points: Astringency, astringency, and aftertaste are slightly good, but have a slightly low efficacy.
1 point: Good taste such as astringency, astringency, and aftertaste, but almost no efficacy.
Based on the above, the evaluation is performed in increments of 0.5 points, the points are totaled to obtain an average value, and those that do not exceed 2.0 and 3.5 are preferred. A value of 2.0 or more and not exceeding 3.0 is more preferable.

  Hereinafter, the present invention will be described in detail with reference to examples, but the present invention is not limited thereto.

Example 1
OPC-containing plant extract (trade name: Flavangenol, manufactured by Toyo Shinyaku Co., Ltd.) and sphingolipid-containing rice extract (80% by weight of cellulose (trade name: Theola ST-02, manufactured by Asahi Kasei Co., Ltd.) A composition having a mixed powder ratio of 20% by weight was manufactured using a product name: Orizaceramide-P (containing 3% by weight of sphingolipid, manufactured by Oriza Oil Chemical Co., Ltd.). The charging amount was about 1 kg, and mixing was performed by mixing plastic bags. Each composition was subjected to a sensory test according to the above-mentioned criteria and evaluated by five expert panelists.
Table 1 shows the change in the mixing ratio and the evaluation of the produced composition.

Example 2
Composition as in Example 1 except that konjac koji extract (product name: konjac ceramide (powder type sphingolipid 3 wt%, including cyclodextrin), manufactured by Unitika Ltd.) was used as the sphingolipid-containing material. A product was manufactured and evaluated in the same manner.
Table 2 shows the change in the mixing ratio and the evaluation of the produced composition.

Example 3
Example 1 except that wheat extract (trade name: Nissan N-ceramide (including 4% by weight of sphingolipid, including purified wheat flour and silicon dioxide), manufactured by Nippon Oil & Fats Co., Ltd.) was used as the sphingolipid-containing material. A composition was produced in the same manner as described above and evaluated in the same manner.
Table 3 shows the change in the mixing ratio and the evaluation of the produced composition.

Example 4
Except for using a rice germ extract (trade name: Nipinceramide RPS (containing 6% by weight of sphingolipid, containing cyclic oligosaccharide) manufactured by Nippon Flour Co., Ltd.) as the sphingolipid-containing material, the same as in Example 1. The compositions were manufactured and evaluated in the same manner.
Table 4 shows the change in the mixing ratio and the evaluation of the produced composition.

Example 5
OPC-containing plant extract (trade name: Pycnogenol, manufactured by Tradepia Co., Ltd.) and sphingolipid-containing rice extract (trade name) against 80% by weight of cellulose (trade name: Theola ST-02, manufactured by Asahi Kasei Corporation) : Orizaceramide-P (containing 3% by weight of sphingolipid, including calcium carbonate, starch degradation product), mixed powder of 20% by weight of Oriza Oil Chemical Co., Ltd.) Manufactured. The charging amount was about 1 kg, and mixing was performed by mixing plastic bags. The sensory evaluation of the produced composition was the same as in Example 1.
Table 5 shows the change in the mixing ratio and the evaluation of the produced composition.

Example 6
69 g of sample (6) in Example 1, 777 g of fire spine extract, 111 g of vitamin C (VC-80R, manufactured by NOF Corporation), sucrose fatty acid ester (Ryoto Sugar Ester S-370F, Mitsubishi Chemical Foods Co., Ltd.) ) 25 g and fine silicon dioxide (Silopage 760, manufactured by Fuji Silysia Chemical Ltd.) 18 g were weighed and mixed. The obtained mixture was pressure-molded so that the weight of one tablet was 290 mg to obtain tablets.
As a result of taking the tablets, it was determined that continuous drinking is possible because there was no difficulty in drinking such as a strong bitter taste and there was a feeling of efficacy of weak astringency.

Example 7
Using the tablets prepared in Example 6, the skin beautifying effect was evaluated.
The tablet of Example 6 was used as a test food, and a double-blind test with placebo was performed. The subjects were 13 healthy women in their 40s and 50s, and the study was randomly divided into 6 test food groups and 7 placebo groups. The placebo was prepared with the same appearance as the test food. That is, lactose (lactose (200M), manufactured by Megre Japan Co., Ltd.) 730g, cellulose (Theola ST-02, manufactured by Asahi Kasei Co., Ltd.) 160g, gardenia pigment (natural yellow FT-6B, manufactured by Ikeda Sacchar Co., Ltd.) 67 g, 25 g of sucrose fatty acid ester (Ryoto Sugar Ester S-370F, manufactured by Mitsubishi Chemical Foods Co., Ltd.) and 18 g of fine silicon dioxide (Silopage 760, manufactured by Fuji Silysia Chemical Co., Ltd.) were weighed and mixed. The obtained mixture was pressure-molded so that the weight of one tablet was 290 mg to obtain placebo tablets.
The intake period was 2 months. The test food and placebo were to be ingested freely 4 times a day for each group. The examination was performed immediately before the start of intake and immediately after the end of intake (2 months after the intake).
The evaluation items were the amount of melanin, the amount of water, and the amount of water transpiration as an index of skin beautifying effect. The measurement site for the amount of melanin and water was the cheek, and the measurement site for the water transpiration was the upper arm. In order to maintain the same environment as much as possible, prepare a room (room temperature 20 ± 5 ° C, relative humidity 50 ± 10%) set to the specified conditions before the measurement. We had you wait calmly for more than 20 minutes in the set room.
The measurement of the amount of melanin used Curage + Khazaka Electronic GmbH "Mexameter MX18". This apparatus measures light reflected from the skin by irradiating the skin with light having wavelengths of 660 nm and 880 nm.
The moisture content was measured by using “Corneometer CM825”, Courage + Khazaka Electronic GmbH. This apparatus uses the fact that the electrokinetic constant of water is significantly different from the dielectric constant of other substances, and indirectly calculates the amount of stratum corneum from the capacitance that varies depending on the amount of water in the stratum corneum.
As the amount of water transpiration, “Tewameter TM210” of Corporation + Khazaka Electronic GmbH was used. This device assumes that the water evaporating from the surface of the skin or object diffuses according to Fick's law, and calculates the transpiration rate (g / hm2) from the value by measuring the temperature and humidity of the water passing through the sensor. Is.

<Result>

As a result, a marked improvement effect was observed for each item of the amount of melanin (Table 6), the amount of water (Table 7), and the amount of water transpiration (Table 8) compared to the placebo group of the test food group. In particular, the effect on the amount of melanin was remarkable. These improvement effects are effects that are effective for skin beautification such as prevention of dull skin, prevention of rough skin, improvement of skin color, or prevention of wrinkles.
From the above, it was confirmed that the composition of the present invention has a skin beautifying effect such as prevention of dull skin, prevention of rough skin, improvement of skin color, or prevention of wrinkles.

The composition according to the present invention can assist in eating habits as food, in particular, health food, so-called supplements. Therefore, the present invention is used for industries in the field.

Claims (30)

Look contains a proanthocyanidin and sphingolipids, composition for oral administration, wherein the ratio of proanthocyanidin and sphingolipid is the ratio from 8.3: 1 100: 1 by weight. The composition according to claim 1, wherein the proanthocyanidins are formulated to be orally administered at 10 mg to 300 mg per day per adult. The composition according to claim 1 or 2 , wherein the proanthocyanidin is a condensation polymer of flavan-3-ol and / or flavan-3,4-diol. The composition according to claim 3 , wherein the degree of polymerization of the condensation product of flavan-3-ol and / or flavan-3,4-diol is 2-4. The composition according to any one of claims 1 to 4 , wherein the proanthocyanidins are derived from a pine bark extract.   The composition according to any one of claims 1 to 5, wherein the sphingolipid is a substance containing a long-chain fatty acid amide structure of sphingosine. The composition according to any one of claims 1 to 6 , wherein the proanthocyanidin is a condensation polymer of flavan-3-ol and / or flavan-3,4-diol, and the sphingolipid is ceramide. The composition according to claim 7 , wherein the degree of polymerization of the condensation polymer is 2 to 4. A food comprising the composition according to any one of claims 1 to 8 . The food according to claim 9 , wherein the shape is a tablet. The food according to claim 9 or 10, which has a beautifying effect. A food containing the composition according to any one of claims 1 to 8, having a skin-beautifying effect, and having a display indicating that it is used for obtaining the skin-beautifying effect. The food according to claim 11 or 12 , wherein the skin beautifying action is prevention of dull skin, prevention of rough skin, improvement of skin color, or prevention of wrinkles. The skin quality improving agent containing the composition in any one of Claims 1 thru | or 8 . The dullness prevention agent of the skin containing the composition in any one of Claims 1 thru | or 8. The melanin production inhibitor in the skin containing the composition in any one of Claims 1 thru | or 8. A skin beautifying agent comprising proanthocyanidins and sphingolipids, wherein the ratio of proanthocyanidins and sphingolipids is a ratio of 3.7: 1 to 150: 1 by weight. The skin beautifying agent according to claim 17, wherein the proanthocyanidins are formulated so as to be orally administered at 10 mg to 300 mg per day per adult. The skin beautifying agent according to claim 17 or 18, wherein the ratio of proanthocyanidins and sphingolipids is 8.3: 1 to 100: 1 by weight. The skin beautifying agent according to any one of claims 17 to 19, wherein the proanthocyanidins are a condensation polymer of flavan-3-ol and / or flavan-3,4-diol. The skin-beautifying agent according to claim 20, wherein the degree of polymerization of the condensation product of flavan-3-ol and / or flavan-3,4-diol is 2-4. The skin beautifying agent according to any one of claims 17 to 21, wherein the proanthocyanidins are derived from a pine bark extract. The skin beautifying agent according to any one of claims 17 to 22, wherein the sphingolipid is a substance containing a long-chain fatty acid amide structure of sphingosine. The skin beautifying agent according to any one of claims 17 to 23, wherein the proanthocyanidins are a condensation polymer of flavan-3-ol and / or flavan-3,4-diol, and the sphingolipid is ceramide. The skin-beautifying agent according to claim 24, wherein the degree of polymerization of the condensation polymer is 2-4. The skin beautifier according to any one of claims 17 to 25, which is used for preventing skin dullness, preventing rough skin, improving skin color, preventing wrinkles, or suppressing melanin production in skin. A proanthocyanidin taste improver comprising sphingolipid, wherein the sphingolipid is mixed in a weight ratio of 3.7: 1 to 150: 1 with respect to proanthocyanidins. 28. The taste improver according to claim 27, wherein the ratio of proanthocyanidins and sphingolipids is 8.3: 1 to 100: 1 by weight. A method for improving the taste of proanthocyanidins, comprising mixing proanthocyanidins and sphingolipids in a weight ratio of 3.7: 1 to 150: 1. 30. The method for improving taste according to claim 29, wherein the ratio of proanthocyanidins and sphingolipids is from 8.3 to 1 to 100 to 1 in weight ratio.