JP4743486B2 - Medical diagnosis support system using capillary blood flow at fingertips. - Google Patents

Description

  The present invention relates to a medical diagnosis support system using capillary blood flow for observing the movement of capillary blood flow in the nail epithelium of a fingertip.

  Conventionally, by continuously observing the blood flow of capillaries (Fig. 1 (a)) in the nail epithelium at the fingertips, continuous and dynamic changes such as capillary diameter, blood velocity, flow rate, and blood vessel density You can make measurements. As shown in FIG. 1 (b), when the nail epithelium A2 at the boundary between the nail A1 of the fingertip A and the skin is magnified with a microscope, the skin is thin and the capillary A3 is seen through the blood. In particular, the movement of hemoglobin in red blood cells can be observed. Based on this measurement result, it can be used to find and treat many diseases, such as heart disease, burns, hepatitis, leukemia, anemia, bronchial asthma, diabetes, rheumatism, pneumonia, pregnancy toxemia, etc. Can be used for discovery and treatment.

For this reason, a microscope for observing the blood flow in the capillary has been developed in order to enlarge and observe the movement of the blood flow in the capillary at the nail epithelium of the fingertip. Patent Document 2 is proposed.
The outline of the inventions of Patent Document 1 and Patent Document 2, which are prior arts, are an objective lens corresponding to a fingertip that is an observation object in an apparatus for magnifying and observing the blood flow of capillaries in the nail epithelium of the fingertip. A plurality of small light sources, for example, light emitting diodes are arranged close to each other so as to irradiate the observation target with light having a wavelength of 410 nm to 580 nm, and light having a wavelength that reacts with hemoglobin in the blood. , Irradiates the nail epithelium of the fingertips so that the movement of blood flow in capillaries can be accurately grasped, and is placed near the periphery of the objective lens to make a capillary blood flow observation device that is small and easy to handle. is there.
Further, Patent Document 3 discloses a technique for managing the health condition by observing and measuring the movement of blood flow in capillaries in the nail epithelium of the fingertip.
Japanese Patent No. 3025671 JP 2000-206118 A JP 2002-277747 A

However, the technique for managing the health situation disclosed in the above-mentioned Patent Document 3 by simply observing the blood flow of the fingertip capillaries simply classifies patterns (shapes) from image observations and compares them with standard patterns. However, the technology of how to support diagnosis is not disclosed, and the health situation is not objectively judged. However, the disclosed technique of Patent Document 3 is the same as those disclosed in Patent Document 1 and Patent Document 2 as long as the image results of these apparatuses are analyzed. It is basically the same as the disclosed technology.
That is, in a conventional capillary blood flow apparatus for observing the movement of capillary blood flow in the nail epithelium of a fingertip, a medical diagnosis support system that automatically and objectively analyzes a health condition and displays the result Is not provided.
The present invention has been made in view of the above-mentioned problems, and the problem is that by automatically observing a color moving image in which the blood flow of capillaries in the nail epithelium of the fingertip is enlarged, The present invention provides a medical diagnosis support system based on capillary blood flow in the nail epithelium of a fingertip that objectively analyzes a health condition and displays the result.

In order to solve the above-mentioned problem, the invention of claim 1 is a system for observing blood vessels and blood flow with a color moving image obtained by enlarging a capillary vessel portion of a fingertip nail epithelium . The density is calculated by counting the number of capillaries per unit length, the thickness of the blood vessels is calculated by measuring the diameter of the capillaries' import or export ports, and the shape of the blood vessels is twisted or deformed blood vessels. Count the number of blood vessels and calculate the ratio to the total number of capillaries and set it as a numerical value. As the blood flow velocity, observe the red blood cells moving in the capillaries and set the flow velocity as a numerical value . These numerical values are stored in the system in advance. Compared with the numerical data in the standard table, the data is classified into classes, and the classified data is analyzed and evaluated by the analysis evaluation means, and the result is output to the display means as a comprehensive evaluation of the health condition. It is a medical diagnosis support system according to claim Rukoto.
According to a second aspect of the present invention, in the medical diagnosis support system according to the first aspect, the blood flow velocity in the moving image is synchronized with the moving direction and speed of the red blood cells in the blood vessel of the color moving image. A mark is selected from the speed table of the measurement operation unit, it is confirmed that the mark is almost synchronized, and a flow velocity is calculated from the selected mark by a calculation means of the system to obtain a numerical value for the analysis evaluation .
According to a third aspect of the present invention, in the medical diagnosis support system according to the first aspect, the blood vessel density in the moving image is input by the operator by counting the number of snare capillaries in the color moving image and inputting it from the operation terminal. The number per unit length is calculated from the input number by the calculation means of the system to obtain a numerical value .

  According to the medical diagnosis support system using capillary blood flow at the fingertip of the present invention, the operator observes the thickness, length, density, shape, blood flow movement, etc. of the capillary at the nail epithelium of the fingertip, and the operator operates the operation terminal. By inputting predetermined marks and numerical values into the color moving image, automatically and objectively acquire the numerical value of the target item, analyze the objective health condition based on the acquired numerical value, and obtain the result It can be displayed and can be used for medical diagnosis support.

  According to the study by the present inventors, the wavelengths that strongly react with the hemoglobin of the blood vessels in the nail epithelium of the fingertip are 540 nm and 576 nm, which penetrates the living tissue of the nail epithelium of the fingertip relatively well, and the oxygenated state of hemoglobin As the light source with wavelengths of 540 nm and 576 nm is known, the amount of light at this wavelength can be changed. By using a mercury lamp containing a lot and using a halogen lamp as a light source with a wavelength range of about 700 nm to 950 nm, blood vessels and blood flow in the nail epithelium of the fingertip can be clearly confirmed compared to conventional devices In addition, the biological tissue of the nail epithelium can be clearly confirmed, and various numerical data can be acquired by inputting predetermined marks on the moving image surface based on the clear color moving image displayed by this device. This One of the features is that the acquired data and the analysis data accumulated so far are compared and analyzed, the health condition is analyzed automatically and objectively, and the result is displayed.

First, an embodiment suitable for a capillary blood flow observation device of a fingertip used in the present invention will be described based on the drawings.
FIG. 2 is a diagram showing an outline of the entire capillary blood flow observation device for observing the nail epithelium portion A2 of the fingertip, but the outline is optically enlarged mainly on the nail epithelium portion A2 of the fingertip that is the observation target. An optical processing mechanism B for creating an image is provided, and a fingertip fixing mechanism C for fixing a fingertip is provided on the base 2 so as to correspond to the optimum position of the objective lens of the optical processing mechanism B. This fingertip fixing mechanism C A fingertip irradiation mechanism D for irradiating light to an optimal position of the nail epithelium portion A2 fixed to the object is provided in the vicinity of the objective lens, and a light source mechanism E connected by an optical fiber is connected to the fingertip irradiation mechanism D.
On the other hand, an imaging mechanism F that electrically processes an enlarged image by the optical processing mechanism B is provided on the upper portion of the optical processing mechanism B, and the imaging mechanism F is an analysis system such as a personal computer that analyzes an image including a captured moving image ( (Analysis mechanism) G is connected.

[Optical processing mechanism B]
The optical processing mechanism B is provided with an objective lens 11 at the lower end and an imaging mechanism F for electrically processing the image of the fingertip A2 at the upper end, and an objective distance for focusing according to a predetermined objective lens. The adjustment knob 12 is used to adjust the vertical movement mechanism 13 so that a clear image of the capillary A3 (FIG. 1) on the nail epithelium A2 (FIG. 1) of the fingertip A2 is formed.
The up-and-down moving mechanism 13 may be a known mechanism, and is optical by rotating a gear (not shown) interlocked with the adjustment knob 12 with respect to a toothed rod (not shown) provided on the base 2 of the observation apparatus. The entire processing mechanism B is configured to slide, and is adjusted so as to form a clear image of the objective lens 11 and the capillary A3 (FIG. 1).

[Fingertip fixing mechanism C]
The fingertip fixing mechanism C fixes the fingertip corresponding to the optimum position of the objective lens 11 of the optical processing mechanism B, and is provided on the base 2 under the objective lens of the optical processing mechanism B. On the upper surface of the base 2, a fingertip fixing member 3 for placing and fixing the fingertip A so that the fingertip does not move freely, and this fixing member 3 are rotatable (arrows in FIG. 3 (a)) and are positioned in a horizontal plane. A horizontal movement mechanism 4 for operating a movable upper board 41 that moves freely is provided.
As shown in FIGS. 3 and 4, the fingertip fixing member 3 is a disc 31 having a diameter of about 3 to 4 cm and a thickness of about 1 cm, and has a semicircular cross section including the center of the disc 31. The groove 32 is provided, and as shown in FIG. 3 (b), the fingertip completely enters the groove 32, and the fingertip is fixed. A rotating shaft 34 is provided at the center of the bottom surface 33 of the disc 31 and is supported rotatably at a substantially central portion of the moving upper board 41 of the horizontal moving mechanism 4.

Further, as shown in FIGS. 4 and 5, the horizontal movement mechanism 4 (41 to 48) is provided between the base 2 and the moving upper board 41, and moves the moving upper board 41 in the left-right (X) direction. As a mechanism, a toothed rod 42 is provided on the lower surface of the moving upper board 41, and a gear 43 meshing with the rod 43 and a left / right (X) direction adjustment knob 44 for movement adjustment are connected to the gear shaft 431. The lower end of the shaft 431 is supported by a bearing 432 on the base 2 side.
Similarly, a moving mechanism in the front / rear (Y) direction is installed between the upper surface of the moving mechanism in the left / right (X) direction and the moving upper plate 41. A rod 45 is provided, and a gear 46 that meshes with the rod 45 is provided, and this gear 46 is connected to a longitudinal movement adjusting knob 47 for movement adjustment in the longitudinal (Y) direction on the hollow gear shaft 461. The shaft 431 is coaxially and rotatably supported in the hollow gear shaft 461, and an intermediate portion of the hollow gear shaft 461 is supported by a bearing 48. The bearing 48 is fixed to the base 2 side.
As shown in FIG. 5, the gear shaft 431 that adjusts the left-right direction and the hollow gear shaft 461 that adjusts the front-rear direction are provided coaxially, and the adjustment knob part is also integrated, with the left-right movement at the upper end. The adjustment knob 44 is integrally provided with a longitudinal movement adjustment knob 47 below it.
Therefore, when the operator moves the moving upper panel 41, the left / right movement adjustment knob 44 and the forward / backward movement adjustment knob 47 can be operated only by moving a fingertip by placing a hand on one adjustment knob portion.

  It is important to observe the nail epithelium part A2 of the fingertip because the magnification is very large, so even a little movement is shifted from the target range of the objective lens 11, and this shift is reduced as much as possible. Is to find the nail epithelium part A2. For this reason, the [fingertip fixing mechanism C] is necessary, and the [fingertip irradiation mechanism D] that reacts with blood vessels and skin tissues as described below is also essential.

[Fingertip irradiation mechanism D]
The fingertip is fixed to the fingertip fixing mechanism C, and the nail epithelium part A2 is adjusted to the optimal position corresponding to the objective lens 11 by adjusting the right / left movement adjusting knob 44 and the longitudinal movement adjusting knob 47. To do. Here, it is necessary to irradiate light of a wavelength that reacts with hemoglobin in the blood of the nail epithelium A2 of the fingertip in an optimal state by the fingertip irradiation mechanism D. The optical fiber fingertip irradiation section 5 of this fingertip irradiation mechanism D As shown in FIGS. 6 and 7, an optical fiber 51 whose outer periphery is coated with a vinyl coating material 511 is connected, and an irradiation portion 52 at the end (tip) of the optical fiber 51 is fitted and fixed with a metal hollow support member 53. ing.
The hollow support member 53 rotates around the objective lens 11 and is supported by a cylindrical irradiation part support member 55 having a hollow hole 551 at the center so as to be freely slidable up and down (slid in the direction of the arrow in FIG. 6). An operation knob 531 for operation is provided on the other end of the support member 53, and the operation knob 531 is operated to be fixed at a desired position to the position of the hollow support member 53 by a fixing screw 553.

The irradiation support member 55 has a side portion 552 fixed to a skew support plate 56 having a predetermined angle with respect to a horizontal plane. The skew support plate 56 is connected to a horizontal support plate 57 positioned horizontally. The horizontal support plate 57 is provided with a rotation support hole 571 to be attached to the objective lens 11, and the rotation support hole 571 has an appropriate pressing force on the fitting groove 111 provided on the outer periphery in the vicinity of the objective lens 11. Is attached so as to be freely rotatable.
Accordingly, the hollow support member 53 is rotatable about the objective lens 11, has a predetermined angle with respect to the vertical of the nail epithelium A2 of the fingertip, and enables irradiation from an oblique side surface of 360 degrees, The distance between the irradiation part 52 at the tip of the optical fiber and the nail epithelium A2 at the fingertip can be adjusted.

[Light source mechanism E]
2 and 8, the light source mechanism E is connected to the irradiation mechanism D by optical fibers 51, 51a, 51b and supplies light. The light source 6 of the light source mechanism E is provided in the light source frame 61. Is provided with a light source power source control unit 62 and a light source chamber 63. The light source chamber 63 is provided with two types of light sources, a mercury lamp 64 and a halogen lamp 65, and the light from each lamp is temporarily collected by condensing mirrors 66 and 67. Supply to each optical fiber 51a, 51b, join the optical fibers 51a, 51b, combine the two kinds of light with the optical multiplexer 68, supply to the optical fiber 51, the combined light from the tip irradiation unit 52 to the fingernail Irradiate on epithelium A2.
The front ends of the optical fibers 51a and 51b on the light source chamber 63 side are covered with metal hollow support members 58a and 58b, and fixed to the fitting holes 591a and 591b of the fixing members 59a and 59b on the light source chamber 63 side, respectively. It is fixed with screws 592 and the like. Here, the hollow support member 58a and the hollow support member 58b have different outer diameters, and the corresponding fitting holes 591a and fitting holes 591b also have different inner diameters, so that the optical fibers 51a and 51b are connected to the light source chamber. Even if they are mistaken when reattached to the 63 fixing members 59a, 59b, either one can be inserted into the fitting hole, so that no mistake is made.
Here, the two types of mercury lamp 64 and halogen lamp 65 are used because the light having a wavelength near 540 nm and 576 nm is light having a wavelength that optimally reacts with hemoglobin in blood. This is because the main wavelength of the light is around 540 nm and 576 nm, and the state of hemoglobin in the blood can be more clearly discriminated, and light with a wavelength of about 700 nm to 950 nm is relatively well transmitted through living tissue such as skin. This is because the state of the nail epithelium A2 is irradiated in a distinguishable manner, and the main wavelength of the halogen lamp 65 is 780 nm within the above range.

Here, the details of the power supply device of the light source power supply control unit 62 will be described with reference to FIG. 8. This power supply device is supplied with power such as AC 100 V from a commercial power supply 621, and firstly mercury through a main power switch 622. The lamp (main light source) 64 is supplied with power by the main light source power circuit 623.
In addition, power is supplied to the halogen lamp (sub-light source) 65 via the main power switch 622. First, the halogen lamp (sub-light source) is supplied by the sub-light source power circuit 625 and the light amount adjustment circuit 626 via the sub-light source power switch 624. ) 65 light quantity can be adjusted to an appropriate amount. The adjustment of the light quantity adjustment circuit 626 can be easily operated by a light quantity adjustment knob 627 provided on the front panel of the power supply device.
Here, FIG. 9 is a monochrome photograph of a nail epithelium of a fingertip irradiated with a conventional mercury lamp (main light source) 64, and a mercury lamp (main light source) 64 and a halogen lamp (sub-light source) 65 are combined. A monochrome photograph of the irradiated microscope is shown in FIG. 10, and it can be seen that blood vessels, blood flow, and skin are clearly clear when the halogen lamp (sub-light source) 65 is also used.
However, although FIGS. 9 and 10 are monochrome, FIG. 10 is actually clearer in a color photograph, and the change in the color of the nail epithelium can be discriminated.
As described above, this device can irradiate the capillaries of the nail epithelium part of the fingertip with light in an accurate wavelength range as compared with the conventional capillary blood vessel observation device of the nail epithelium part of the fingertip, and the corresponding fingertip The blood vessels and blood flow in the nail epithelium can be clearly confirmed, and the living tissue of the nail epithelium can also be clearly confirmed.

[Imaging mechanism F]
An imaging mechanism F that electrically processes an enlarged image by the optical processing mechanism B is rotatably provided on the upper portion of the optical processing mechanism B as shown in FIG. Here, the imaging mechanism F is rotatable so that the screen of the next personal computer screen is rotated so that the examiner can easily see the blood vessel state. Of course, it may be rotated by the image processing means on the personal computer screen.
The operation of the image pickup mechanism F and the analysis system (analysis mechanism) G will be described with reference to the block diagram of FIG. 11. The image pickup mechanism F includes a high-definition image pickup unit 71 having about 5 million pixels such as a CCD and an image. A processing unit 72 is provided to electrically process images of blood vessels, blood flow, and skin tissue of the fingertip nail epithelium A2 processed optically, and connect to an analysis system (analysis mechanism) G such as the next personal computer. To do.
Of course, if the resolution is high, it is clear even if the color moving image is enlarged.

[Analysis system (analysis mechanism) G]
In this analysis system (analysis mechanism) G, the captured image is once displayed on the monitor 81 which is a display terminal of the analysis system (analysis mechanism) G, and from the displayed screen, the skin under the nail epithelium is displayed. The measurement operation unit (keyboard) 82, which is an operation terminal, is used to operate the capillaries in the blood vessel and the state of blood flowing through the capillaries. The imaging data acquisition unit / measurement data acquisition unit 83 allows the operator to operate the operation terminal. The measurement operation unit (keyboard) 82 is used to mark a predetermined position on the color moving image surface of the monitor 81, or the number is input, and the measurement value is automatically calculated by the calculation means of the analysis system, or The data is manually taken in, the analysis unit 84 analyzes the health condition of the subject based on the taken data, and the result is displayed again on the monitor 81 as a display terminal.
The measurement data captured by the measurement data capture unit 83 is processed into numerical values such as length and speed and input to the analysis unit 84. The specific configuration of the analysis unit 84 is roughly composed of the data comparison unit 85 and the analysis evaluation. And means 86.
In the data comparison means 85, a first comparison is made between the numerical values of the processed measurement data and the predetermined numerical data calculated from the experience values stored in the first reference table (1) 852 in the system. The comparison and evaluation means 86 first compares the comparison data from the comparison means 851 with the analysis rank classification means 861 and distributes them to each rank, all these data distributed by the analysis rank classification means 861 or predetermined data. The second comparison means 862 compares this data with predetermined numerical data calculated from the empirical values stored in the second reference table (2) 863 in the analysis system G. The comprehensive evaluation is output by the means 864, and the result is subjected to predetermined signal processing by the analysis unit 84 and displayed on the monitor 81 which is a display means.

As mentioned above, the claw epithelium is thin and the capillaries can be seen through a microscope by continuous and dynamic measurement of the diameter, blood velocity, flow rate, blood vessel density, etc. It is possible to observe the movement of hemoglobin in blood, especially red blood cells, and it can be used for the detection and treatment of many diseases such as heart disease, burns, hepatitis, leukemia, anemia, bronchial asthma, diabetes, rheumatism, pneumonia, pregnancy toxemia etc. it can.
Therefore, a procedure and a process for automatically acquiring the operation of the operator and the measurement value will be described with reference to FIG. 12 which is the screen of the monitor 81 of this apparatus.
The specific vascular state observations for that purpose are the sharpness of the snare capillaries (difference between (a) and (d) in FIG. 12), the snare capillaries density (the snare capillaries per single length) ), The diameter of the capillary import (inflow) port appearing on the skin of the nail epithelium (x1 in FIG. 12 (c)), and the diameter of the capillary export (outflow) port (in FIG. 12 (c)) x2), the ratio of these apertures, the tip diameter of the snare (x3 in FIG. 10 (c)), the length of the snare (x4 in FIG. 12 (b)), the number of twisted blood vessels (FIG. 13 (e)), The number of deformed blood vessels (FIG. 13 (f)), the flow velocity (x5 in FIG. 12 (a)), and the like.

In other words, these are based on the data obtained by the inventor's many years of experience,
(1) Regarding the clarity of the snare capillaries, if the tissue metabolism is normal, the reflection of the blood vessels becomes clear, and if it is unclear, the metabolism may be abnormal.
(2) the snare vascular density (number of snare capillaries per single digit length), in order to maintain the metabolism of tissue to a normal state, since it is required a certain number of capillaries, predetermined If it is less than the density, the metabolism may be abnormal.
(3) The diameter (x1) of the capillary import (inflow) port appearing on the skin of the nail epithelium is positively correlated with the amount of blood flowing from the artery, so an indicator of whether the blood flow is normal or not Become.
(4) The diameter (x2) of the capillary export (outflow) port is related to the return of blood in the capillary to the vein, and this is also an indicator of whether the blood flow is normal.
(5) The ratio of export / import caliber represents the ratio of blood volume entering and exiting capillaries, so whether the blood flow is normal as in (3) and (4) above. It becomes an indicator.
(6) The diameter of the snare crest (x3) represents the stagnation of blood in the capillaries, and if the caliber is too narrow, it becomes an index of blood stagnation.
(7) The length of the snare (x4) is the length of the capillaries, but is related to the area to be metabolized.
(8) The number of twisted blood vessels (e) indicates that the blood vessel wall is easily damaged and blood flow is liable to occur.
(9) The number of deformed blood vessels (f) represents vascular damage or abnormal state of the blood vessels, and there is a possibility that there is a disorder.
(10) The blood flow velocity (x5) in the blood vessel is related to blood viscosity and cardiac contraction force, and deviating from the predetermined flow velocity may indicate a problem with the heart and blood viscosity. .

Therefore, the fact that these numerical values deviate from normal values can be used as an index for the discovery and treatment of many diseases described above.
The numerical values for (1) to (10) described above (although there are other numerical values) are acquired by operating the input means of the operator, and stored in the comprehensive evaluation means of the system health examination. Compared with the data of 1 standard table, it sorts by rank, analyzes from each of these distributed data, evaluates each data comprehensively with the 2nd standard table by comprehensive evaluation means, and displays the result Is displayed on the monitor 81. Furthermore, it prints with a printer as needed.

Next, each data acquisition procedure will be described.
[1] Regarding (1) blood vessel definition, “1” if the blood vessel can be clearly recognized from the image of the monitor 81, “0” if the blood vessel cannot be recognized, and “2” if neither can be said. Is input to the analysis system G by the measurement operation unit 82, and the input data is input to the analysis unit 84 and is used as a judgment material for the comprehensive evaluation means 864 for system health diagnosis.
[2] Similarly, the (2) for snare vascular density (number of snare capillaries per single digit length), (in this example 1mm) units cuticle length number per ( Although in FIG. 1 (b) to enter by counting the number seven) on the screen, the actual screen both ends of the color video plane distance, magnification automatically read by the computing means from the imaging data acquisition unit 83 The density is also automatically calculated by the calculation means 83 of the system. This density is usually 7 / mm or less, and the numerical value is normal, and if it is higher than that, it becomes abnormal. Depending on the degree, the analysis rank from the first reference table (1) 852 stored in the analysis system G It is assigned to a predetermined rank by the dividing means 861 and becomes a judgment material of the comprehensive evaluation means 864.

[3] Regarding (7) concerning length measurement (the same applies to (3), (4), and (6)), the procedure for measuring the snare length (x4) will be described with reference to FIG. . As shown in FIG. 10, the snare capillaries mean horseshoe-shaped capillaries.
First, in step 1, about three clear snare capillaries are selected from the blood vessels in FIG. 1B and FIG. The white circle y1 is input by the cursor operation, and the black circle y2 is input by the cursor operation at the blood vessel export entrance in step 2. Thereby, the calculation means (calculation circuit) 83 of the system G calculates the distance x4 between y1 and y2, that is,
(Formula 1) x4 = √ ((y0−y1) ² + (y0−y2) ² )
In step 3, the average value of the three snare capillaries x4 is calculated by the calculation means 83, and the obtained numerical value is input to the analysis unit 84 of the system, and the first reference value table ( X4 = 200 μm, which is the data of 1), is assigned as a normal value to a predetermined rank by the analysis rank dividing means 861 of the analysis system G and becomes a judgment material of the comprehensive evaluation means 864.
[4] The calculation of the export / import ratio in (5) above is based on the above (3) and (4). The predetermined numerical data in one reference table (1) 852 is compared with the comparison means 851, and is distributed to a predetermined rank by the analysis rank dividing means 861, which becomes the judgment material of the comprehensive evaluation means 864.
[5] The operator inputs the number of (8) the number of twisted blood vessels, (9) the number of deformed blood vessels, and the total number of the blood vessels from the image of the monitor 81, and inputs the twist, (Or) The density (ratio) of deformed blood vessels is calculated by the arithmetic circuit of the analysis system G, and assigned to a predetermined rank from the first reference table stored in the analysis system G.

[6] As described above, the movement of red blood cells (hemoglobin) in the blood can be observed, but the measurement of the flow velocity (x5) in the blood vessel of (10) is based on the color moving image of the monitor 81 (( Confirm red blood cell migration as shown in a). As procedure 1, here, the same measurement direction as the flow direction of red blood cells that can be confirmed is selected from the direction pattern displayed on the screen by the operation terminal 82, or the direction is manually set. Select a speed close to the speed from the speed table.
Then, on the line r in the selected or set direction, the white circle mark ○ a1 in FIG. 12A moves along the selected direction toward the black circle mark ● a2 at the selected speed. In step 3, the operator compares this white circle mark ○ with the movement of red blood cells to confirm whether the movement of the red blood cells and white circle marks ○ is almost synchronized. Select from the speed table and correct it so that it is almost synchronized. In step 5, if you confirm that it is almost synchronized and press the Enter key on the measurement operation unit 82, the flow rate is automatically calculated by the calculation means 83 of the system. The obtained numerical value is input to the analysis unit 84 of the analysis system G, and the predetermined speed (μm / s) is obtained from the table of the first reference table (1) 852 stored in the system G in the same manner as each numerical value described above. (Movement distance / movement time) is compared with the first comparison means 851, and is assigned to a predetermined rank by the analysis rank division means 861, which is used as a judgment material for the comprehensive evaluation means 864.

  The comprehensive evaluation means 864 uses the numerical data ranked by the analysis rank classification means 861 for each target item as the material, and the data of the second reference table (2) 863 previously calculated from the experience data and all the measured data. Or, the predetermined data is analyzed and evaluated by the second comparing means 862. For example, the health status is output as an analytical evaluation. (1) If all the numerical values are within the normal range, (2) If the indicator is not very important and slightly deviates from the normal value, [Minor abnormality], (3) If there is an abnormal value in one important indicator, [Severe abnormality] indicate. In other words, the analysis judgment extracted from the data of the second reference table based on the data obtained from the accumulation of experience so far is output, and the degree of normality / abnormality is displayed on the screen of the monitor 81 which is a display terminal Then, it is printed out by a printer as necessary.

As described above in detail, according to the present embodiment, the thickness, density, shape of the snare capillaries of the nail epithelium of the fingertips and the movement of the blood flow are observed, and the color moving image is operated by the operation terminal such as the operator's keyboard. By inputting a predetermined mark or numerical value into the image, the numerical value of the target item is automatically and objectively acquired, and the objective health condition is analyzed based on the acquired numerical value and the result is displayed. Can be used for medical diagnosis support.
In addition, it is possible to accurately irradiate the capillaries of the nail epithelium of the fingertip with an appropriate amount of light, and to quickly and accurately fix the fingertip nail epithelium corresponding to the microscope objective lens at the optimal position. Data on the state of capillaries under the nail epithelium skin and blood flowing in the nail epithelium can be taken in quickly and accurately, and the biological tissue of the nail epithelium can be clearly confirmed.
Needless to say, the present invention is not limited to the above-described embodiments as long as the features of the present invention are not impaired.

It is the figure which expanded nail epithelium part A2 with the microscope, and appeared on the display terminal screen. 1 is an overall schematic view of a capillary blood flow observation device according to an embodiment of the present invention. 3A is a perspective view of a fingertip fixing member of the fingertip fixing mechanism in FIG. 2, FIG. 3B is a perspective view in which the fingertip is fixed to the member, and FIG. 3C is a sectional view of the member. It is. It is a top view of the horizontal movement mechanism of the fingertip fixing | fixed part mechanism of FIG. FIG. 5 is a cross section of the main part of the horizontal movement mechanism of the fingertip fixing part mechanism taken along line (5)-(5) in FIG. 4. FIG. 3 is a perspective view of a fingertip irradiation mechanism D in the vicinity of the objective lens in FIG. 2. It is sectional drawing of the fingertip irradiation mechanism D of FIG. FIG. 3 is a block diagram of a light source power source control unit 62 in FIG. 2. It is a monochrome photograph figure of the microscope of the fingernail nail epithelium irradiated only with the conventional mercury lamp. It is the photograph figure which made the color photograph of the microscope of the fingernail nail epithelium irradiated by combining a mercury lamp and a halogen lamp into a monochrome. It is a block diagram explaining the action | operation of the imaging mechanism F and the analysis system (analysis mechanism) G of the Example of this invention. It is explanatory drawing explaining the procedure which acquires numerical data from the image displayed on the monitor of the Example of this invention. It is explanatory drawing which showed the specific example of the twisted blood vessel and the malformed blood vessel in the image displayed on the monitor of the Example of this invention.

Explanation of symbols

A ... fingertip, A1 ... nail, A2 ... nail epithelium, A3 ... snail capillary B ... optical processing mechanism, C ... fingertip fixing mechanism, D ... fingertip irradiation mechanism,
E ... Light source mechanism, F ... Imaging mechanism, G ... Analysis system (analysis mechanism),
11 ... objective lens, 111 ... fitting groove, 12 ... objective lens distance adjustment knob,
13: Vertical movement mechanism,
2 ... the base,
DESCRIPTION OF SYMBOLS 3 ... Fingertip fixing member, 31 ... Disc, 32 ... Groove, 33 ... Bottom, 34 ... Rotating shaft 4 ... Horizontal movement mechanism, 41 ... Moving upper board, 42, 45 ... Toothed rod, 43, 46 ... Gear,
431 ... Gear shaft, 432 ... Bearing, 44 ... Left / right adjustment knob, 461 ... Hollow gear shaft,
47 ... Longitudinal adjustment knob, 48 ... Bearing,
5 ... Optical fiber fingertip irradiation unit, 51, 51a, 51b ... Optical fiber,
511 ... Vinyl covering part, 52 ... Tip irradiation part, 53, 58a, 58b ... Hollow support member,
531 ... Operation knob, 55 ... Irradiation part support member, 551 ... Hollow hole, 552 ... Side part,
553,592 ... Fixing screw, 56 ... Skew support plate, 57 ... Horizontal support plate, 571 ... Rotation support hole,
59a, 59b ... fixing member, 591a, 591b ... fitting hole,
6 ... light source, 61 ... light source frame,
62 ... Light source power control unit, 621 ... Commercial power supply, 622 ... Main power switch,
623 ... Main light source power circuit, 624 ... Sub light source power switch, 625 ... Sub light source power circuit,
626 ... Light quantity adjustment circuit, 627 ... Light quantity adjustment knob, 63 ... Light source room,
64 ... Mercury lamp, 65 ... Halogen lamp, 66,67 ... Condenser mirror, 68 ... Optical multiplexer,
71 ... High-definition imaging unit, 72 ... Image processing unit,
81 ... Monitor (display terminal), 82 ... Measurement operation unit (operation terminal),
83 ... Shooting data fetching unit / Measurement data fetching unit / Calculation means, 84 ... Analysis unit,
85 ... Data comparison means, 851 ... First comparison means, 852 ... First reference table (1),
86 ... Analysis evaluation means, 861 ... Analysis rank division means, 862 ... Second comparison means,
863 ... second reference table (2), 864 ... comprehensive evaluation means,

Claims (3)

In a system that observes blood vessels and blood flow with a color moving image that enlarges the capillary blood vessels of the nail epithelium at the fingertip, the number of capillaries per unit length is counted from the obtained moving image as the density of blood vessels. The thickness of the blood vessel is the numerical value obtained by measuring the diameter of the import or export port of the capillary, and the shape of the blood vessel is calculated by calculating the ratio to the total number of capillaries by counting the number of twisted or deformed blood vessels. As the blood flow velocity, the red blood cells moving in the capillaries are observed, and the flow velocity is set as a numerical value . These numerical values are compared with the numerical data of the reference table stored in the system in advance, and are classified into classes. A medical diagnosis support system characterized in that these classified data are analyzed and evaluated by an analysis and evaluation unit, and the result is output to a display unit as a comprehensive evaluation of the health condition. Regarding the blood flow velocity in the moving image, the operator selects a mark that synchronizes with the moving direction and velocity of red blood cells in the blood vessel of the color moving image from the velocity table of the measurement operation unit, and confirms that it is almost synchronized. The medical diagnosis support system according to claim 1, wherein a flow velocity is calculated from the selected mark by a calculation means of the system to obtain a numerical value for the analysis evaluation . Regarding the density of blood vessels in the moving image, the operator counts the number of snuff capillaries in the color moving image and inputs it with the operation terminal, and calculates the number per unit length from the input number by the calculation means of the system. The medical diagnosis support system according to claim 1, wherein the medical diagnosis support system is a numerical value .

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