JP4787964B2 - Culture schedule management device and culture schedule management program - Google Patents

Description

  The present invention relates to a technique for managing a schedule for performing a plurality of steps on a cell collected from a living organism and culturing the cell using one or a plurality of work spaces.

A technique for performing a plurality of steps on a cell collected from an organism and culturing the cell is known. Such a technique is used, for example, for human treatment or research on life forms.
When culturing cells, first, the cells are collected from the living organism, and the collected cells are stored in a culture chamber maintained in a predetermined state (temperature state, humidity state, etc.). At the same time, the cells are periodically removed from the culture chamber, and a predetermined process (enzyme treatment, etc.) is performed on the cells using a predetermined work space (clean bench, cell adjustment room, incubator, safety cabinet, inspection room, etc.). And culture the cells. In addition, the collected organisms, the types, the cells for different purposes, etc. are treated separately. Hereinafter, the differentiated cell is referred to as a specimen. When culturing cells, the cells are managed for each specimen.
When culturing a plurality of specimens, it is necessary to create a culture schedule for each specimen such as when and which work space is used for each process. In the work space for carrying out the process on cells, in order to prevent contamination (misplacement of cells, contamination, etc.), it is said that the process (process) should not be carried out on two or more specimens in the same work space at the same time. Safety standards are established. Therefore, the culture schedule of each specimen (that is, the implementation date and time and the implementation work space of each process) must be created so as not to overlap the implementation date and time and the implementation work space of each process of other specimens.
For the reasons described above, conventionally, the availability of a work space is managed by a work space manager, and each worker manually creates a culture schedule for each specimen while observing this availability.

  Patent Document 1 discloses an apparatus for creating a production schedule for products produced on a production line sharing the same equipment. However, the technique of Patent Document 1 does not relate to a technique for creating a schedule for culturing cells, and the safety standards as described above are not required when producing a product. Therefore, when creating a schedule for culturing cells, the technique of Patent Document 1 cannot be applied as it is.

Japanese Patent Laid-Open No. 7-234897

As described above, conventionally, each worker manually creates a culture schedule for each specimen while checking the availability of the work space. However, in order to culture cells, it is necessary to perform many steps on the cells. For this reason, it took a great effort to determine the implementation date and time and the implementation work space of each process while checking the availability of the work space.
Moreover, in order to culture | cultivate a cell efficiently, it is necessary to implement as many processes as possible in one working space. However, as described above, in order to prevent contamination of each specimen, it is necessary to perform a process so that the implementation date and time and the implementation work space do not overlap with other specimens. Therefore, even if an attempt is made to increase the number of culture samples per work space, there is no time in which the work space is free (time when the work space is not used), and a culture schedule for each sample cannot be created. As a result, there was a limit to the number of culture samples per work space.

  The present invention has been made in view of the above-described circumstances, can prevent contamination with high safety, and can increase the number of cells to be cultured (the number of specimens) per work space. An object of the present invention is to provide a culture schedule management device capable of automatically creating a cell culture schedule.

From the experience of culturing a large number of cells, the inventors of the present invention have a process that can be omitted as necessary from a process that must be performed (a highly important process) in each process of culturing cells. It has become possible to cultivate many cells in one working space by using this characteristic. In other words, if the work space is not available at the time when the low importance process is performed, the low importance process is omitted (decided not to be executed). Made possible.
The culture schedule management device of the present invention includes a first storage unit storing a standard schedule for each step of culturing cells, and a second storage unit storing importance indicating the necessity of performing each step. A third storage means for storing a work space use schedule indicating the use schedule of each work space, a setting means, a selection means, a first determination means, a first determination means, a second determination means, and a second determination means. And a calculation means having an input means for inputting the start time of culturing of a new cell to the calculation means . The setting means sets the scheduled execution time of each step of culturing the cell from the culture start time input by the input means and the standard schedule of the cell stored in the first storage means . The selection means selects one process to be performed first from among the processes for which the execution schedule and the execution work space are not determined, among the processes for which the scheduled execution time has been set by the setting means . The first determination means is a work space use schedule in which the third storage means stores whether or not there is an empty work space that can be used to execute the process at the scheduled execution time of the process selected by the selection means. Judgment is made from the work space availability shown in FIG. When it is determined by the first determination means that there is an available work space , the first determination means sets the usable time and work space as the execution time and work space of the process selected by the selection means. To decide . The second determination means reads the importance of the process selected by the selection means from the second storage means when the first determination means determines that there is no available work space, and based on the read importance Te to determine whether it is necessary to perform the process. The second determination unit determines not to perform the step selected by the selection unit when the second determination unit determines that the step selected by the selection unit does not need to be performed . As long as it is not determined when it is necessary to implement selected by the selecting means step by the second determination means, calculation means, selection means, the first judging means and the first determining means Wakashi Ku is selected means, first By operating the determination means, the second determination means, and the second determination means, the presence or absence of execution of each step of culturing cells or the execution timing and the execution work space are determined.
In this culture schedule management device, when there is no available work space available at the scheduled execution time of the selected process, the second determination means executes the selected process based on the importance of the selected process. Determine whether it is necessary. And when it is not necessary to implement the selected process, the 2nd determination means determines not to implement the selected process. Therefore, when there is no empty work space at the scheduled execution time of a process of low importance, a culture schedule that does not execute the process is created. Therefore, it is possible to create a culture schedule that does not overlap with other cells (specimens) and the implementation time and the implementation work space, and that can start culture at the start of culture.

The culture schedule management apparatus described above preferably updates the work space use schedule stored in the third storage means based on the execution time and the execution work space of each step determined by the first determination means .
According to such a configuration, since the culture schedule is reflected in the work space use schedule after the culture schedule is created, the culture schedule can be suitably created when a new cell culture schedule is created next time.

In addition, even if it is a process that must be performed among the processes for culturing cells, the timing for performing the process may be changed. Therefore, it is preferable that the culture schedule management apparatus described above further includes a fourth storage unit that stores a change allowable range of processes that must be performed . Moreover, it is preferable that a calculating means further has a 3rd determination means and a 3rd determination means. The third determination unit reads the change allowable range of the process from the fourth storage unit when the second determination unit determines that the process selected by the selection unit needs to be performed, and reads the read allowable change range. Whether or not there is a free work space that can be used to perform the process during the period is determined from the work space availability status indicated in the work space use schedule stored in the third storage means . When it is determined by the third determining means that there is an available work space , the third determining means sets the usable time and work space as the execution time and work space of the process selected by the selecting means. To decide .
According to such a configuration, when there is no available working space at the scheduled execution time of a process that must be performed, the third determination means can be used during the period of allowable change of the selected process. It is determined whether there is a free work space. Then, when there is an empty work space that can be used during the change allowable range, the usable time and work space are determined by the third determining means as the execution time and work space of the selected process. Therefore, even when there is no available work space available at the scheduled execution time of a process that must be performed, it is possible to create a culture schedule that can start culture at the start of culture and culture cells appropriately.

In the culture schedule management apparatus described above, it is preferable that the calculation means further includes a process addition means. The process adding means is configured such that the period between the process selected by the selection means and the previous process is a predetermined time by determining the execution time and execution work space of the process selected by the selection means by the third determination means. When it becomes longer than the above, a new process having a scheduled execution time is added in the period between the process selected by the selection means and the previous process .
According to such a configuration, when the period between the execution timing of the selected process and the execution timing of the previous process becomes longer than a predetermined time, a new scheduled execution time is set in that period. A process is added. Therefore, it is possible to create a culture schedule in which the period between steps does not exceed a predetermined time.

In the culture schedule management apparatus described above, it is preferable that the calculation means further includes a resetting means. The resetting means, when the execution time and execution work space of the process selected by the selection means are determined by the third determination means, the determined execution time and the cell stored in the first storage means From the standard schedule, the scheduled execution time of each process after the process selected by the selection means is reset . The selecting means selects one process to be executed first among the processes for which the execution time and the execution work space are not determined among the processes for which the scheduled execution time is set by the setting means or the resetting means.
According to such a configuration, it is possible to more suitably determine the execution time of the process after the process in which the execution time and the execution work space are determined by the third determining unit.

In addition, the present invention provides a culture schedule management program capable of starting culture at the start of culture and creating a culture schedule capable of suitably culturing cells even in a situation where there is not much free work space.
The culture schedule management program includes a first storage unit storing a standard schedule for each step of culturing cells, a second storage unit storing importance indicating the necessity of performing each step, A computer having third storage means for storing a work space use schedule indicating a work space use schedule, calculation means, and input means for inputting the start time of culturing of a new cell to the calculation means. Using one or a plurality of work spaces, a cell collected from a living organism is subjected to a plurality of steps and a schedule for culturing the cell is managed. That is, this program is a setting step for setting the scheduled execution time of each step of culturing the cell from the standard schedule of the cell stored in the first storage unit and the culture start time input by the input unit ; a selection step of selecting one step carried out in the earliest among the steps implemented timing and implementation work space has not been determined among the processes scheduled implementation time has been set in the setting step, is selected in the selection step Whether or not there is a free work space that can be used to execute the process at the scheduled execution time of the process is determined based on the work space availability status indicated in the work space use schedule stored in the third storage means . When it is determined that there is a free work space that can be used in the first determination step and the first determination step, the usable space can be used. A first determining step of determining a period and work space as an timing and implementation workspace step selected in the selection step, when it is determined that the free working space is not available in the first determination step, the selection step A second determination step for reading out the importance of the process selected in the second storage means, and determining whether or not the process needs to be performed based on the read importance , and the process selected in the selection step when it is determined in the second determination step is not necessary to implement, it is intended to execute a second determination step of determining that not performed selected in the selection step process calculating means. As long as it is not determined in the second determination step when it is necessary to perform the selected in the selection step process, the calculation unit, select step, first determination step and the first determining step Wakashi Ku is selected step, the The first determination step, the second determination step, and the second determination step are executed to determine whether or not each step for culturing cells is performed or when it is performed, and an execution work space.
With this culture schedule management program, create a culture schedule that does not overlap with other cells (specimens) and implementation time, and can start culture at the start of culture, even when there is not enough work space Can do.

The main features of the embodiments described in detail below are listed first.
(Embodiment 1) The culture schedule management device manages a schedule for culturing cells by performing a plurality of steps on cells collected from a human using one or a plurality of work spaces.
(Mode 2) The culture schedule management apparatus includes a first storage unit, a second storage unit, a third storage unit, a fourth storage unit, an input unit, a setting unit, a selection unit, and a first determination unit. And a first determining means, a second determining means, a second determining means, a third determining means, a third determining means, a process adding means, and a resetting means.
(Mode 3) The first storage means stores a standard schedule for each step of culturing cells.
(Form 4) The 2nd memory | storage means has memorize | stored the importance which shows the necessity of implementation of each process.
(Mode 5) The third storage means stores a work space use schedule indicating the use schedule of each work space.
(Mode 6) The fourth storage means stores a change allowable range of the execution time of the process having high importance.
(Mode 7) The input means inputs a start time of culturing of a cell for newly culturing.
(Mode 8) The setting means sets the scheduled execution time of each step of culturing the cell from the input culture start time and the standard schedule of the cell.
(Mode 9) The selecting means selects one of the plurality of steps for culturing the cell, the step to be performed first among the steps for which the execution time and the execution work space are not determined.
(Mode 10) The first determination means determines whether or not there is an empty work space that can be used to perform the process at the scheduled execution time of the selected process, based on the work space availability status indicated in the work space use schedule. judge.
(Embodiment 11) When it is determined by the first determination means that there is an empty work space that can be used, the first determination means performs the use time and the work space in which the work space is selected. Determine as.
(Mode 12) Whether or not the second determination means needs to perform the process based on the importance of the selected process when the first determination means determines that there is no available work space. Determine whether.
(Mode 13) The second determining means determines not to perform the selected process when it is determined that the process selected by the second determining means is not required to be performed.
(Embodiment 14) When it is determined that the process selected by the second determination means needs to be performed, the third determination means can be used to execute the process during the change allowable range of the process. Whether there is a free work space is determined from the work space free status indicated in the work space use schedule.
(Embodiment 15) When it is determined by the third determination means that there is a free work space that can be used, the third determination means performs the use time and the work space in which the work time and the work space are selected. Determine as.
(Mode 16) The process adding means is configured such that the execution time and execution work space of the selected process are determined by the third determining means, so that the period between the selected process and the previous process becomes a predetermined time or more. When it becomes long, a new process with a scheduled execution time is added in a period between the selected process and the previous process.
(Mode 17) The resetting means, when the execution time and execution work space of the selected process are determined by the third determination means, the process selected from the determined execution time and the standard schedule of the cell Reset the scheduled implementation time for each process.
(Embodiment 18) The culture schedule management device is the selection means, the first determination means and the first determination means or the selection means, the first determination means, unless it is determined by the third determination means that there is no available work space. , By operating the second determination means and the second determination means or the selection means, the first determination means, the second determination means, the third determination means, the third determination means, the step addition means, and the resetting means, Decide whether or not to perform each step of culturing, the timing of execution, and the working space.
(Mode 19) The culture schedule management apparatus updates the work space use schedule based on the determined execution time and execution work space of each process.

  Hereinafter, preferred embodiments of the present invention will be described with reference to the drawings. FIG. 1 shows a culture schedule management apparatus 10 of the present invention. The culture schedule management apparatus 10 is installed in a hospital or the like and manages a schedule for culturing cells collected from a patient. Before describing the culture schedule management apparatus 10, a process of culturing cells will be described.

  In hospitals, treatment is performed in which cells are collected from a patient's body, the collected cells are cultured, and the patient is treated using the cultured cells. When cells are collected from a patient's body by a doctor, the collected cells are transported to a cell processing center (hereinafter referred to as CPC (Cell Processing Center)). In CPC, a cell is transferred to a container, and an ID number for identifying the cell is assigned to the cell in the container. Hereinafter, a cell to which one ID number is assigned is referred to as one lot of cells. Since cells are collected from a large number of patients in a hospital, the cells of each patient are managed as different lots in CPC. In addition, cells collected from the same patient may be divided into a plurality of lots according to the purpose. Therefore, CPC manages many lots of cells. The cell to which the ID number is assigned is transferred together with the container into the culture chamber in the CPC and stored there. Cells stored in the culture chamber are periodically removed from the culture chamber and subjected to various processes. As a result, the cells are cultured. Each step to be performed on the cells is performed in a clean bench (a work place for performing work under aseptic conditions). Two clean benches X and Y are installed in the CPC of the present embodiment, and each process is performed by any one of the clean benches.

  The culture schedule management apparatus 10 manages the cell culture schedule for each lot. That is, the culture schedule of when and which clean bench is used to perform each step performed on the cells of each lot is managed. Moreover, the culture schedule management apparatus 10 creates a cell culture schedule for newly starting culture. As shown in FIG. 1, the culture schedule management apparatus 10 includes a server 20 and a plurality of communication terminals 42 to 48 connected to the server 20 via a communication line 40.

  The server 20 includes an arithmetic device 22, a storage device 24, an input device 26, and a display device 28. The storage device 24 stores process execution condition data 30, clean bench schedule data 32, culture schedule data 34, and a culture schedule creation program 36.

  As shown in FIG. 2, the process execution condition data 30 describes the standard execution date, standard processing time, importance, executable time, and change allowable range for each cell culturing process. The step of the process execution condition data 30 shows a standard series of steps for culturing cells. The standard execution date indicates the standard execution date (the number of days elapsed from the start date when cell culture is started) for each step in which cells can be suitably cultured. For example, the standard execution date of the pretreatment process is the first day of starting the culture, and the standard execution date of the final adjustment process is the 20th day after starting the culture. The standard processing time indicates the time required to perform the process. The standard processing time is set to the maximum necessary time when the process is normally performed. For example, the standard processing time of the pretreatment process is 2 hours, and the normal treatment time indicates that the pretreatment process can be completed within 2 hours. Note that the process, standard execution date, and standard processing time in FIG. 2 are standard schedules indicating the standard execution time of each process. The importance is determined based on the magnitude of the influence on the cells when the process is not performed. The importance level 2 indicates that the process must be performed, and the importance level 1 indicates that the process does not necessarily have to be performed. The feasible time indicates a time during which each step can be performed. The feasible time is determined according to the importance of each process. The importance 2 process can be performed from 9:00 to 17:00 on weekdays, and the importance 1 process can be performed from 9:00 to 19:00 on weekdays and holidays. Yes. The change allowable range is a change allowable range of the implementation date of the process of importance level 2 and indicates how late the process may be performed.

  As shown in FIG. 3, the clean bench schedule data 32 is data indicating the use schedule of the clean benches X and Y. That is, the clean bench schedule data 32 indicates which process is used for which lot of cells the clean benches X and Y are used in each time zone. For example, from 9:00 to 10:00 on 2006/7/3, clean bench X is used to perform a pretreatment step on lot A cells, and clean bench Y is applied to lot E cells. It is used to carry out the recovery and passage process.

  As shown in FIG. 4, the culture schedule data 34 is data indicating the execution time of each process of the cells of each lot and the clean bench used for performing the process. For example, it is shown that the pretreatment process of the cells of lot A is performed using clean bench X at 9:00 to 11:00 on 2006/7/3.

  The culture schedule creation program 36 is read out and executed by the arithmetic unit 22. As a result, the processing unit 22 is caused to execute a process for creating a cell culture schedule for newly starting culture.

  The input device 26 includes a keyboard, a mouse, and the like and is connected to the arithmetic device 22. A signal is input to the arithmetic device 22 by operating the input device 26.

  The display device 28 is connected to the arithmetic device 22 and displays an image according to a signal input from the arithmetic device 22.

  The arithmetic device 22 is constituted by a CPU, a ROM, a RAM, and the like. The arithmetic device 22 is connected to a storage device 24, an input device 26, and a display device 28. Various signals are input from the input device 26 to the arithmetic device 22. The arithmetic device 22 is connected to the communication line 40. The arithmetic device 22 receives various data transmitted from the communication terminals 42 to 48 via the communication line 40. The arithmetic device 22 performs an arithmetic operation according to a signal input from the input device 26 or data received from the communication line 40. The calculation result by the calculation device 22 is displayed on the display device 28. Moreover, the arithmetic unit 22 creates a culture schedule for cells to be newly started by executing the culture schedule creation program 36. The computing device 22 executes the culture schedule creation program 36 to set the setting means, the selection means, the first determination means, the first determination means, the second determination means, the second determination means, and the third described in the claims. It functions as a determination unit, a third determination unit, a process addition unit, and a resetting unit.

The communication terminal 42 is installed in the CPC. The communication terminal 42 is connected to the server 20 via the communication line 40. The communication terminal 42 includes an arithmetic device 42a, an input device 42b, and a display device 42c.
The input device 42b includes a keyboard, a mouse, and the like, and is connected to the arithmetic device 42a. A signal is input to the arithmetic device 42a by operating the input device 42b.
The display device 42c is connected to the arithmetic device 42a and displays an image according to a signal input from the arithmetic device 42a.
The arithmetic device 42a is configured by a CPU, a ROM, a RAM, and the like. The arithmetic device 42 a is connected to the server 20 via the communication line 40. The arithmetic device 42a is connected to the input device 42b and the display device 42c. The computing device 42a performs computation according to the signal input from the input device 42b, and displays the computation result on the display device 42c.
For example, by operating the input device 42 b of the communication terminal 42 and inputting a predetermined signal to the arithmetic device 42 a, the process execution condition data 30 stored in the arithmetic device 42 a via the communication line 40 is stored in the process execution condition data 30. The bench schedule data 32, the culture schedule data 34, and the like can be read, and the data read by the arithmetic device 42a can be displayed on the display device 42c. Therefore, the operator in the CPC can confirm the culture schedule of each lot by the communication terminal 42.

  The communication terminal 44 is installed in the room of a quality control department that manages the quality of the cell culture process. The communication terminal 44 is connected to the server 20 via the communication line 40. The communication terminal 44 is configured in the same manner as the communication terminal 42, and includes an arithmetic device 44a, an input device 44b, and a display device 44c.

  The communication terminal 46 is installed in a room of a document management department that manages documents relating to each process performed by the CPC. The communication terminal 46 is connected to the server 20 via the communication line 40. The communication terminal 46 is configured in the same manner as the communication terminal 42, and includes an arithmetic device 46a, an input device 46b, and a display device 46c.

  The communication terminal 48 is installed in a doctor's office that collects cells from a patient. The communication terminal 48 is connected to the server 20 via the communication line 40. The communication terminal 48 is configured in the same manner as the communication terminal 42, and includes an arithmetic device 48a, an input device 48b, and a display device 48c. Further, the communication terminal 48 can transmit a signal instructing the execution of the culture schedule creation program 36 to the server 20 by operating the input device 48b.

  Next, a process of creating a culture schedule for cells to be newly cultured by the culture schedule management apparatus 10 will be described with reference to the flowchart of FIG. When determining the date of surgery for collecting cells from the patient's body by meeting with the patient, the doctor operates the input device 48b of the communication terminal 48, so that the culture schedule creation program 36 is transferred from the arithmetic device 48a to the server 20. A signal for instructing execution is transmitted. When the arithmetic device 22 of the server 20 receives the transmitted signal, it reads out the culture schedule creation program 36 from the storage device 24 and executes it. As a result, the creation of a cell culture schedule for starting a new culture is started.

  When the culture schedule creation program 36 is executed, the arithmetic device 22 transmits predetermined data to the communication terminal 48 and requests the display device 48c of the communication terminal 48 to input the culture start date of the cell to be newly started. Display a message. When the doctor operates the input device 48b to input the culture start date, the arithmetic device 48a transmits data indicating the input culture start date to the server 20. When the computing device 22 of the server 20 receives the transmitted data indicating the culture start date (step S2), it reads the process performance condition data 30 from the storage device 24. Then, based on the standard execution date (see FIG. 2) of each process indicated by the process execution condition data 30 and the received data indicating the culture start date, the execution date data 38 in which the execution date of each process is set is obtained. Create (step S4). At this time, the arithmetic unit 22 starts the culture on the culture start date indicated by the data received in step S2, and sets the scheduled execution date data 38 so as to execute each process according to the standard execution date indicated by the process execution condition data 30. calculate. For example, when the doctor inputs 2006/7/3 as the culture start date, the calculation device 22 calculates the scheduled execution date data 38 in which the scheduled execution date of each step is set as shown in FIG.

  In step S6, the computing device 22 is a process in which the execution date / time (determined in steps S10 and S22 described later) is not determined or is not determined to be performed (determined in step S14 described later). The process performed first is selected. For example, in the first step S6, since the execution date and time of any process is not determined, the preprocessing process that is the first process is selected. Moreover, in step S6 after determining the implementation date and time of the pretreatment process, the primary culture process is selected.

When the process is selected, the arithmetic device 22 reads the clean bench schedule data 32 from the storage device 24. Then, based on the clean bench empty status (see FIG. 3) indicated by the clean bench schedule data 32 and the standard processing time and the feasible time (see FIG. 2) indicated by the process execution condition data 30, the scheduled execution date data 38 is obtained. It is determined whether or not there is an empty clean bench capable of performing the process on the scheduled execution date of the selected process shown (step S8).
For example, let us consider a case where the computing device 22 has selected a pre-processing step in which a scheduled date of execution is set as shown in FIG. 6 and the clean bench is in the situation shown in FIG. At this time, the possible time for the pretreatment process is 9:00 to 17:00 on weekdays. Therefore, the time when the clean bench X is vacant on 2006/7/3, which is the scheduled execution date of the pretreatment process, is 13: 00 to 17:00 from FIG. Moreover, there is no time when the clean bench Y is vacant. On the other hand, the standard processing time of the pretreatment process is 2 hours. Therefore, since the pretreatment process can be performed on the clean bench X in the time zone from 13:00 to 17:00 (that is, the clean bench X is available for 2 hours or more), the arithmetic unit 22 performs the pretreatment process. It is determined that there is an empty clean bench that can be implemented.

When the computing device 22 determines that there is an empty clean bench that can perform the selected process, the computing device 22 determines a time zone in which the scheduled execution date can be performed as the execution date and time of the selected process, The selected process is determined as a clean bench (step S10). At this time, the arithmetic unit 22 determines the earliest time zone among the time zones in which the selected process can be performed as the execution date and time of the selected process.
For example, in the case of the pretreatment process described above, the implementation date is determined at 13: 00 to 15:00 on 2006/7/3, and the clean bench to be implemented is determined as the clean bench X.
When the execution date and time of the process selected in step S10 and the clean bench to be executed are determined, the arithmetic unit 22 executes step S28 described later.

If the arithmetic unit 22 determines that there is no empty clean bench capable of executing the selected process (NO in step S8), the arithmetic unit 22 determines whether the importance of the selected process is 1 (step S12). When the importance of the selected process is 1, the arithmetic unit 22 determines not to perform the selected process (step S14).
For example, when the computing device 22 selects the cell observation process shown in A of FIG. 6 (the cell observation process with the scheduled execution date of 2006/7/5) in step S6, the calculation device 22 performs the determination in step S8. As shown in FIG. 3, if the clean benches X and Y are not vacant on 2006/7/5, the arithmetic unit 22 determines in step S8 that there is no empty clean bench capable of performing the cell observation step A. Moreover, since the importance of the cell observation process A is 1, the arithmetic unit 22 determines YES in step S12. Then, the arithmetic unit 22 determines not to perform the cell observation process A in step S14.
When it is determined not to perform the selected process, the arithmetic unit 22 executes step S28 described later.

If the arithmetic unit 22 determines that the importance is not 1 (that is, the importance is 2) (NO in step S12), the change allowable range (see FIG. 2) of the selected process indicated by the process execution condition data 30 is determined. The changeable period of the process is calculated from the scheduled execution date of the process (step S16). At this time, the changeable period is calculated from the day after the scheduled execution date of the selected process.
For example, when the collection / passage process (cell observation process whose scheduled execution date is 2006/7/9) shown in B of FIG. 6 is selected, 2006/7/9 is Sunday. Since the execution time of the passaging process is 9:00 to 17:00 on weekdays, the arithmetic unit 22 determines NO in step S8. Further, since the importance of the recovery / passage process is 2, the arithmetic unit 22 determines NO in step S12. Then, the arithmetic unit 22 allows the recovery / passage process change allowable range (as shown in FIG. 2, the recovery / passage process change allowable range is 3 days) and the recovery / passage process B scheduled execution date. From 2006/7/9, the period of 2006/7/10 to 2006/7/12 is calculated as the changeable period of the recovery / passage process B.

When the computing device 22 calculates the changeable period of the selected process, the empty cleanbench that can execute the process selected during the calculated changeable period based on the availability of the clean bench, the standard processing time, and the executable time. It is determined whether or not there is (step S18). If it is determined that there is no empty clean bench that can perform the process selected in the calculated changeable period, the computing device 22 sends data indicating that cell culture cannot be started on the culture start date received in step S2 to the communication terminal 48. Transmit (step S20). Then, the arithmetic device 48a of the communication terminal 48 receives the data and displays a message indicating that on the display device 48c. Thus, it is notified that the cell culture cannot be started on the culture start date input by the doctor. In this case, the arithmetic unit 22 terminates the process without changing any data such as the clean bench schedule data 32 and the culture schedule data 34 stored in the storage device 24.
For example, in the case where the recovery / passage process B described above is selected, the clean bench X and the standard processing time of the recovery / passage process for 3 hours or more in the period of 2006/7/10 to 2006/7/12 When Y is not free, the arithmetic unit 22 determines NO in step S18. Then, the arithmetic unit 22 executes step S20 and ends the process. At this time, the arithmetic unit 22 erases the execution date and time and the data of the clean bench to be executed for the process before the collection / passage process B, and does not change any data stored in the storage device 24.

If the arithmetic unit 22 determines that there is an empty clean bench that can perform the process selected during the changeable period (YES in step S18), the operation date / time is determined as the execution date / time of the selected process, and the process can be performed. The clean bench is determined as a clean bench for executing the selected process (step S22). At this time, the arithmetic unit 22 determines the earliest date and time among the dates and times when the selected process can be performed as the execution date and time of the selected process. When determining the execution date and time and the clean bench to be executed, the arithmetic unit 22 changes the scheduled execution date of the process after the selected process in accordance with the execution date of the selected process determined in step S22 (step S24). That is, the execution date of the selected process determined in step S22 is determined to be a date later than the scheduled execution date set in step S4. The computing device 22 delays the scheduled execution date of the process after the selected process by the amount of delay with respect to the scheduled execution date of the selected process. Next, the computing device 22 newly adds a cell observation process on the day between the process selected by the scheduled execution date data 38 and the previous process (step S26).
For example, when the above-described recovery / passage process B is a selected process, if the clean bench X is vacant in the time zone from 13: 00 to 17:00 on July 7, 2006, the recovery / passage process Since the clean bench X is vacant for 3 hours or more, which is the standard processing time for B, the arithmetic unit 22 determines YES in step S18. Then, the arithmetic unit 22 determines the implementation date / time of the collection / passage process B at 13:00 to 16:00 on 2006/7/11 in step S22. In addition, the arithmetic unit 22 determines the clean bench to perform the collection / passage process as the clean bench X. Then, in step S24, the arithmetic unit 22 sets the scheduled execution date of the process after the collection / passage process B in the scheduled execution date data 38 as the execution date of the recovery / passage process B (ie, 2006/7/11). Change to correspond to. Then, the scheduled execution date data 38 shown in FIG. 6 is changed as shown in FIG. Next, the arithmetic unit 22 newly performs cell observation on the day between the cell observation step and the collection / passage step B shown in FIG. 7C (that is, 2006/7/9 and 2006/7/10). Steps D and E are added. As a result, the scheduled execution date data 38 is changed as shown in FIG.

In step S <b> 28, the arithmetic unit 22 determines whether there is a process for which the execution date / time (or not to execute) is not determined among the processes indicated in the scheduled execution date data 38. If there is a process for which the execution date has not been determined, the arithmetic unit 22 selects a new process in step S6. Therefore, the arithmetic unit 22 repeatedly executes steps S6 to S28 until there is no process for which the execution date / time has not been determined, and determines the execution date / time of all the processes (or the cell culture on the received culture start date). Data indicating that it cannot be started is transmitted to the communication terminal 48). Thereby, the culture schedule which shows the implementation date of each process and the clean bench to implement is created.
As described above, in step S4, the arithmetic unit 22 selects a process to be performed first among processes whose execution dates and times are not determined. Therefore, when a cell observation process is added in step S26, the process performed first is selected among the added cell observation processes. In addition, when the execution dates and times of all the added cell observation steps are determined, in step S6, the next step after the step whose execution dates and times are determined in step S22 is selected.
For example, in the scheduled execution date data 38 shown in FIG. 8, the cell observation process D is selected in step S6 after the execution date of the collection / passaging process B is determined. When the execution date and time (or not to execute) of the cell observation step D is determined, the cell observation step E is selected. When the execution date / time of the cell observation process E is determined, the execution date / time of the collection / passage process B has already been determined, so the cell observation process shown in F is selected. In this way, the execution date and time of all the steps indicated by the scheduled execution date data 38 and the clean bench to be executed are determined, and a culture schedule is created as shown in FIG. Since the added cell observation steps D and E are steps of importance 1, the cell observation step is not performed unless a clean bench for performing the cell observation steps D and E is available. Therefore, the addition of the cell observation steps D and E does not affect the already determined recovery / passage step B.

  When the calculation device 22 determines the execution date and time of all the steps and the clean bench to be executed, it updates the culture schedule data 34 and the clean bench schedule data 32 based on the determined execution date and time of each step and the clean bench to be executed ( Step S30). As a result, the culture schedule of the cells to be newly cultured is reflected in the culture schedule data 34 and the clean bench schedule data 32. The computing device 22 transmits the updated culture schedule data 34 and clean bench schedule data 32 to the communication terminal 48 (step S32), and causes the communication terminal 48 to display the created culture schedule. As a result, the doctor is notified of the culture schedule of the cells to be newly cultured. When the arithmetic device 22 transmits the culture schedule data 34 and the clean bench schedule data 32 updated to the communication terminal 48, the processing ends.

  The execution date and time of each process determined as described above can be changed manually by operating the server 20 and the communication terminals 42 to 48. For example, when a manual change is performed by the server 20, the input device 26 is operated to cause the arithmetic device 22 to read the culture schedule data 34 and the clean bench schedule data 32 from the storage device 24. Then, the culture schedule data 34 and the clean bench schedule data 32 are displayed on the display device 28. Next, a process whose execution date / time is desired to be changed is selected by the input device 26, and the date / time when the process is desired to be specified is designated. Then, the arithmetic unit 22 determines whether there is an empty clean bench that can perform the selected process at the designated date and time. At this time, the arithmetic unit 22 determines whether or not there is an empty clean bench that can execute the process at the designated date and time based on the empty condition of the clean bench indicated by the clean bench schedule data 32 and the process execution condition data 30. To do. When there is an empty clean bench at the specified date and time, the arithmetic unit 22 changes the execution date and time of the selected process to the specified date and time. That is, the arithmetic unit 22 changes the execution date and time of the selected process in the culture schedule data 34 and the clean bench schedule data 32. If there is no empty clean bench that can perform the selected process at the designated date and time, the arithmetic unit 22 rejects the change and causes the display device 28 to display a message indicating that the change is rejected. This prevents inappropriate changes from being made.

  As described above, in the culture schedule management apparatus 10 according to the present embodiment, when there is no empty clean bench that can be used on the scheduled execution date of the selected process, the arithmetic unit 22 determines the importance of the selected process. It is determined whether or not it is necessary to carry out the process selected based on it. Then, when it is not necessary to carry out the selected process, it is decided not to carry out the selected process. Therefore, when there is no empty clean bench on the scheduled execution date of the process of importance level 1 (that is, the cell observation process), a culture schedule that does not execute the process is created. Therefore, even in a situation where there are not many empty clean benches, it is possible to create a culture schedule in which other cells (specimens) do not overlap with the implementation time and the clean bench to be implemented, and the culture can be started at the start of culture.

  Moreover, in the culture schedule management apparatus 10, the arithmetic unit 22 updates the clean bench schedule data 32 and the culture schedule data 34 based on the execution time of each step determined for the cell to be newly cultured and the clean bench to be executed. . Therefore, when a new cell culture schedule is created next time, the culture schedule can be suitably created in consideration of the already created cell culture schedule.

  Moreover, in the culture schedule management apparatus 10, when there is no empty clean bench on the scheduled execution date of the process of importance 2, the arithmetic unit 22 can be changed from the scheduled execution date and the allowable change range of the selected process. Calculate the period. If there is an empty clean bench that can carry out the selected process during the changeable period, the time when the process can be performed is determined as the execution time of the selected process, and the process is carried out for the executable clean bench. Decide on a clean bench. Therefore, even when there is no empty clean bench on the scheduled execution date of the process with the importance level 2, other cells (specimens) do not overlap with the execution time and the clean bench to be executed, and the culture can be started at the start of the culture. A culture schedule can be created.

  Moreover, in the culture schedule management apparatus 10, if the arithmetic unit 22 determines the implementation time of the process selected in step S22 on a date different from the scheduled execution date, the execution date of the process selected in step S26 and the execution date of the previous process are determined. A cell observation step with the date between and the scheduled date of execution is added to the scheduled date of execution data 38. Therefore, if the added cell observation step can be performed on the scheduled date of execution, a culture schedule for performing the cell observation step on the day between the selected step and the previous step is created.

  Further, in the culture schedule management apparatus 10, when the calculation device 22 determines the execution time of the process selected in step S22 on a date different from the scheduled execution date, the calculation apparatus 22 re-executes the scheduled execution date of each process after the process selected in step S24. Set. Therefore, the execution time of the process after the selected process is more suitably determined.

  In the culture schedule management apparatus 10 described above, since the cell culturing process is performed in either the clean bench X or Y, a cell culture schedule was created based on the use schedule of the clean bench X and Y ( That is, it can be said that the culture schedule management apparatus 10 created and managed the use schedule of the clean benches X and Y.) However, the present invention is not limited to such a form, and the technology of the present invention is a work space (that is, each process) occupied by one specimen (one cell) when performing each process of culturing cells. This method can be applied to the case of creating and managing a use schedule of a space that is set to be occupied by one specimen at the time of the work. For example, when the process of culturing cells is performed using other work spaces (for example, cell conditioning rooms, incubators, safety cabinets, inspection rooms, etc.), use schedules for those work spaces are created and A cell culture schedule can be created based on the usage schedule. In addition, when the work space used in each process is different (for example, when a laboratory is used for the cell observation process and a clean bench is used for other processes), a use schedule is created for each work space. The cell culture schedule may be created based on the use schedule.

  Moreover, although the culture schedule management apparatus 10 mentioned above created the culture schedule of the cell cultured by CPC, even when culture | cultivating a cell by comparatively small scales, such as a laboratory level, it creates a cell culture schedule. Can do.

  Moreover, in the culture schedule management apparatus 10 described above, when the cell observation process cannot be performed on the scheduled date of execution, the arithmetic unit 22 has decided not to perform the cell observation process, but the present invention is such an embodiment. Not limited to. For example, when the cell observation process cannot be continuously performed for two days or more, data indicating that the culture cannot be started on the culture start date when the arithmetic unit 22 is input may be output.

Moreover, in the culture schedule management apparatus 10 mentioned above, when the arithmetic unit 22 cannot perform the process of the selected importance 2 in a changeable period, the data which show that culture | cultivation cannot be started on the input culture start date are shown. Although output, the present invention is not limited to such an embodiment. For example, when the computing device 22 cannot perform the process of importance level 2 in the changeable period, the execution date and time of the process to be performed on the cells of other lots is changed, and the time when the change is made and the clean bench are changed. You may decide on the implementation time of a process, and the clean bench to implement.
That is, when the importance level 2 process cannot be performed in the changeable period, the computing device 22 determines whether there is a time zone for performing the importance level 1 process in the changeable period in the clean bench X or Y. Judge from. If there is a time zone in which the process of the importance level 1 is performed on the clean bench X or Y in the changeable period, it is next determined whether or not the process of the importance level 2 can be performed in the time zone. When the importance level 2 process can be performed, it is determined not to perform the importance level 1 process for the cells of other lots, and the importance level 2 process is determined to be performed during the time period. Furthermore, when the process of importance 2 cannot be performed in the changeable period, it is searched whether there is a time zone for executing the process of importance 2 in the changeable period, and the searched process of importance 2 can be changed. Determine whether or not. And if the already determined importance 2 process can be changed, the execution time of the already determined importance 2 process is changed, and the current importance 2 process is executed in the vacant place. To decide. For example, when the change period of the process of importance 2 already determined is long and the change period of the process of importance 2 to be determined this time is short, the process of importance 2 already determined is If it can be carried out within the change period, the execution time of the already determined importance 2 process is changed, and the importance 2 process to be determined this time is decided to be executed at that time.
In addition, when the schedule change of the cell of another lot is accompanied, it is preferable to program that the schedule change must be performed by the previous day (that is, it is preferable to program so that the schedule change of the day is prohibited). . Thereby, an operator's work mistake can be prevented. In addition, regarding the next day's work, each worker can confirm the work schedule before the next day's work, thereby eliminating work mistakes.

  In the above-described embodiment, the importance of the cell culturing process is divided into importance 1 and importance 2. However, the importance classification is not limited to this example. The importance of each process may be divided into a plurality of stages according to the importance of the process. For example, the importance level 1 can be omitted, the importance level 2 cannot be omitted, but the execution time can be changed, and the importance level 3 can be changed. For example, regarding the day of collecting cells from a patient (pretreatment process) and the day of performing treatment on a patient (final adjustment process), the implementation time may be a process that cannot be changed (that is, a process of importance 3). it can. In this way, by setting the importance level to three levels, it is possible to prevent the importance level 3 from being changed arbitrarily. In this case, when it is desired to change the execution time for the process of importance 3, it is preferable that only authorized personnel such as doctors and process managers can change the execution time.

Specific examples of the present invention have been described in detail above, but these are merely examples and do not limit the scope of the claims. The technology described in the claims includes various modifications and changes of the specific examples illustrated above.
The technical elements described in this specification or the drawings exhibit technical usefulness alone or in various combinations, and are not limited to the combinations described in the claims at the time of filing. In addition, the technology illustrated in the present specification or the drawings achieves a plurality of objects at the same time, and has technical utility by achieving one of the objects.

The block diagram of the culture schedule management apparatus 10. FIG. The figure which showed process execution condition data 30. FIG. The figure which showed the clean bench schedule data 32. The figure which showed the culture schedule data 34. FIG. The flowchart which showed the process of the arithmetic unit 22 at the time of culture schedule preparation. The figure which showed an example of the implementation date data 38 calculated by step S4. The figure which showed the implementation date data 38 by which the implementation date was changed by step S24. The figure which showed the implementation date data 38 to which the cell observation process was newly added by step S26. The figure which showed an example of the culture schedule produced with the culture schedule management apparatus 10. FIG.

Explanation of symbols

10: Schedule management device 20: Server 22: Computing device 24: Storage device 26: Input device 28: Display device 30: Process execution condition data 32: Clean bench schedule data 34: Culture schedule data 36: Schedule creation program 38: Implementation schedule Date data 40: communication line 42: communication terminal 42a: arithmetic device 42b: input device 42c: display device 44: communication terminal 44a: arithmetic device 44b: input device 44c: display device 46: communication terminal 46a: arithmetic device 46b: input device 46c: Display device 48: Communication terminal 48a: Arithmetic device 48b: Input device 48c: Display device

Claims (6)

An apparatus for managing a schedule for performing a plurality of steps on a cell collected from a living organism and culturing the cell using one or a plurality of work spaces,
First storage means storing a standard schedule for each step of culturing cells;
Second storage means storing importance indicating the necessity of performing each step;
Third storage means for storing a work space use schedule indicating the use schedule of each work space;
A calculation means having a setting means, a selection means, a first determination means, a first determination means, a second determination means, and a second determination means;
Input means for inputting the start time of culturing of cells to be newly cultured to the computing means ;
Have
Setting means, from the standard schedule for that cell culture at the start and the first storage unit which is input by the input means is stored, to set the scheduled implementation time of each step of culturing the cells,
Selection means, processes performed in the earliest among the steps implemented timing and implementation work space has not been determined among the processes scheduled implementation time is set one selected by the setting means,
The first determination means is a work space use schedule in which the third storage means stores whether or not there is an empty work space that can be used to execute the process at the scheduled execution time of the process selected by the selection means. it is determined from the work space availability shown in,
When it is determined by the first determination means that there is an available work space , the first determination means sets the usable time and work space as the execution time and work space of the process selected by the selection means. determined,
The second determination means reads the importance of the process selected by the selection means from the second storage means when the first determination means determines that there is no available work space, and based on the read importance It determines whether it is necessary to perform the step Te,
The second determination means determines that if it is determined when there is no need to implement the selected process by the selecting means by the second judging means, not performed is selected by the selecting means step,
Unless the second determination unit determines that the process selected by the selection unit needs to be performed, the calculation unit includes the selection unit, the first determination unit and the first determination unit or selection unit, the first determination unit, the second determination unit, and the second determination unit. A culture schedule management apparatus characterized by deciding whether or not to perform each step of culturing cells, or performing time and performing work space by activating the determining means and the second determining means. The culture schedule according to claim 1, wherein the work space use schedule stored in the third storage means is updated based on the execution time and the execution work space of each step determined by the first determination means. Management device. A fourth storage means for storing the allowable change range of the process that must be performed ;
The computing means further includes third determining means and third determining means,
The third determination unit reads the change allowable range of the process from the fourth storage unit when the second determination unit determines that the process selected by the selection unit needs to be performed, and reads the read allowable change range. period to determine whether the step has a free working space that can be used to implement the third working space availability for the storage unit is shown in the work space use schedule stored in,
When it is determined by the third determining means that there is an available work space , the third determining means sets the usable time and work space as the execution time and work space of the process selected by the selecting means. To decide ,
The culture schedule management apparatus according to claim 1 or 2, wherein The calculation means further includes a process addition means,
The process adding means is configured such that the period between the process selected by the selection means and the previous process is a predetermined time by determining the execution time and execution work space of the process selected by the selection means by the third determination means. When it becomes longer than the above, a new process in which the scheduled execution time is set in the period between the process selected by the selection means and the previous process is added .
The culture schedule management apparatus according to claim 3. The computing means further has a resetting means,
The resetting means, when the execution time and execution work space of the process selected by the selection means are determined by the third determination means, the determined execution time and the cell stored in the first storage means From the standard schedule, reset the scheduled execution time of each process after the process selected by the selection means ,
The selection means selects one process to be performed first among the processes for which the execution time and the implementation work space are not determined among the processes for which the scheduled execution time has been set by the setting means or the resetting means.
The culture schedule management device according to claim 3 or 4 , wherein A first storage means storing a standard schedule of each step for culturing cells, a second storage means storing importance indicating the necessity of performing each step, and a schedule for using each work space One or a plurality of operations in a computer having third storage means for storing a work space use schedule, calculation means, and input means for inputting the start time of culturing of a cell to be newly cultured to the calculation means A program for managing a schedule for culturing cells by performing a plurality of steps on cells collected from living organisms using a space,
A setting step for setting a scheduled execution time of each step of culturing the cell from the standard schedule of the cell stored in the first storage unit at the start of culture input by the input unit ;
A selection step for selecting one of the processes to be performed first among the processes for which the execution time and the execution work space are not determined among the processes for which the scheduled execution time is set in the setting step;
The empty work space indicated in the work space use schedule stored in the third storage means whether or not there is an empty work space that can be used to execute the process at the scheduled execution time of the process selected in the selection step. A first determination step for determining from the situation;
When it is determined that there is an available work space available in the first determination step, a first determination step of determining the usable time and work space as the execution time and work space of the process selected in the selection step When,
When it is determined that there is no available work space in the first determination step, the importance level of the process selected in the selection step is read from the second storage means, and the process is executed based on the read importance level. A second determination step for determining whether it is necessary;
A second determination step for determining not to perform the process selected in the selection step when it is determined in the second determination step that the process selected in the selection step does not need to be performed ;
Is executed by the calculation means ,
Unless it is determined in the second determination step that the process selected in the selection step needs to be performed, the calculation means includes a selection step, a first determination step and a first determination step or selection step, a first determination step, a second A culture schedule management program characterized by causing the determination step and the second determination step to be executed to determine whether or not each step of culturing cells is performed or when it is performed and when the work space is performed.

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