JP4808991B2 - Deodorant film preparation - Google Patents

Description

  The present invention relates to a deodorizing film preparation for preventing malodor from the body.

Traditionally, for bad odors from the body, especially odors (odor odors) and foot odors, you can take a bath frequently, take a shower to remove sweat and dirt, and shave your side hair to bacterium. It is common to use antiperspirant / deodorant agents in addition to daily skin care that suppresses the growth of the skin (for example, Patent Document 1).
However, its deodorizing effect is inadequate, and with respect to scents, by inserting heat into the pores and applying heat to weaken the function of the apocrine sweat gland, the apocrine sweat gland outlet is blocked and sweat that causes odor comes out. There are permanent hair removal and surgery to remove apocrine sweat glands with scissors (pruning method), but it is not a perfect method, and it is painful in addition to going to hospital, and it has a heavy physical and financial burden Currently.
There is no special treatment for the smell of the foot, and in addition to the use of antiperspirant / deodorant agent in addition to the small washing of the foot and changing the socks, it does not have a sufficient deodorizing effect Is the current situation.
Also, in sports and leisure (golf, baseball, racing, driving, etc.) that use gloves, deodorants may be applied to the fabric itself such as gloves, but even the body itself has even taken anti-odor measures. There is no current situation.
JP-A-4-257514

By the way, the odor is a state where the armpit smells and is called “smelly odor”, but the cause of the odor is sweat under the armpit. There are two types of sweat glands that produce sweat: eccrine sweat glands and apocrine sweat glands. The eccrine sweat gland is in the whole body and plays a role in regulating body temperature by secreting sweat, and the apocrine sweat gland is only in specific parts such as the armpits, vulva, breasts, navel, and anal area, and there is mental tension. Secretes sweat when strong.
Apocrine sweat glands develop during secondary growth and are therefore considered to be closely related to sex hormones. The sweat produced from apocrine sweat glands contains proteins, lipids, sugars, and the like. Among these components, particularly lipids are decomposed by resident bacteria (resident bacteria) on the skin surface, become lower fatty acids, and have a unique odor (poisonous odor).
In addition, the smell of the foot generates a unique odor by degrading the protein derived from the sweat and the stratum corneum of the skin secreted from the eccrine line on the sole of the foot, by resident bacteria on the skin surface.

Anti-perspirant and deodorant agents in addition to daily skin care, such as taking frequent baths, taking showers, and shaving the eyelashes to improve the high humidity environment where bacteria are likely to propagate However, commercially available antiperspirant / deodorant agents contain antibacterial ingredients that temporarily block sweat holes by local astringent action and prevent bacterial growth. Most of them were temporary, had an insufficient deodorizing effect and were not durable.
Most of the preparations are external preparations such as creams and ointments. However, application to the affected area is troublesome, and there are many formulation defects that require washing after use or soiling clothes and socks with the applied preparation. In addition, there is a high probability of being washed away by daily bathing or showering, and it was necessary to reapply each time.

  The present invention has been made in view of the above problems, and the inventor of the present invention has a drawback of conventional antiperspirant / deodorant agents by forming a water-resistant film on the skin (dirt of hand to be applied, The problem of the present invention is simply to prevent the odor and foot odor. An object of the present invention is to provide a preparation that can improve the sustainability of the deodorizing action and can effectively prevent the deodorization.

The present inventor has conducted various experiments on what kind of substance should be used for what kind of formulation to easily and hygienically and continuously prevent the odor and foot odor. .
As a result of taking into account the weaknesses of conventional external preparations such as creams, ointments, and gels, the preparation itself dries after application, and if a film is formed, it eliminates stains on clothes and applied hands due to the preparation after application. The ODT effect (sealing) of the affected area improved the penetration of the drug into the skin and improved the drug's effect and persistence.
In addition to covering the affected area with a coating, the effect of confining the odor itself and blocking the air by blocking the air, there is also no loss of the drug due to washing the affected area by bathing or showering. I realized that I could expect a lasting deodorant effect. As a result of further research based on this fact, the inventor was able to complete the present invention.

That is, in order to solve the above-mentioned problem, the invention of claim 1 dissolves nitrocellulose in a solubilizer of 3-methylbutyl acetate (isopentyl acetate) , isobutyl acetate, or acetone, or a mixture thereof, The preparation is made by adding ethyl alcohol. After application to the skin, the solvent is volatilized, and the affected part is sealed by forming a transparent or translucent film of nitrocellulose with a thickness of 10μ to 100μ on the skin. In addition, it is a deodorizing film preparation characterized by preventing the odor and odor of feet and the like from spreading.
The invention according to claim 2 is characterized in that natural oil is added to the solubilizer to improve the fluidity of the preparation and the toughness of the film after film formation. It is.
The invention according to claim 3 is the deodorant film preparation according to claim 2, wherein the natural oil is selected from perilla oil, sesame oil, sesame oil, olive oil, horse oil, castor oil, and hinoki oil.
The invention according to claim 4 is an antibacterial and / or bactericidal action selected from salicylic acid, menthol, peppermint oil, perilla seed extract, propolis, cinnamon extract (cinnamaldehyde), hinokitiol, and isopropylmethylphenol. 2. The deodorizing film preparation according to claim 1, wherein a natural or synthetic substance having the above is added.
The invention according to claim 5 is the deodorizing film preparation according to claim 1, wherein the preparation contains a sulfur compound.
The invention according to claim 6 is the deodorizing film preparation according to claim 5, wherein the sulfur compound is methylsulfanylmethane (MSM).
The invention of claim 7 is the deodorizing film preparation according to claim 1, characterized in that the preparation contains a substance having a local convergence action.
According to an eighth aspect of the present invention, the substance having a local astringent action is potassium potassium sulfate, zinc oxide, kaolin, plant extract (hypericum extract, Atlantic kizuta extract, maroni extract, grape leaf extract, shinano extract, hamamelis extract, cornflower) The odor-preventing film preparation according to claim 7, which is a substance selected from an extract and the like.

  Therefore, the deodorizing film preparation according to the present invention dissolves nitrocellulose, which is a film forming body, with isoamyl acetate, isobutyl acetate, acetone, or a mixture thereof, and further increases the amount by adding ethyl alcohol. Antibacterial agents, astringents, natural oils, sulfur compounds are dissolved and contained, and after dissolution of isoamyl acetate, isobutyl acetate, and ethyl alcohol, which are solubilizing agents applied to the affected area, in a few minutes due to body temperature, A nitrocellulose 10 μm to 100 μm transparent film is formed on the skin surface of the affected area, and the affected skin is covered with the formed transparent film.

Further, the blending ratio of nitrocellulose as the film forming body and isoamyl acetate, isobutyl acetate and acetone as the dissolving agent is 3: 1 to 1:10, preferably 2: 1 to 1: 5, more preferably 1: 1. This is because when the amount of nitrocellulose is large, it is difficult to uniformly apply to the skin, and when the amount is small, it is difficult to form a sealed film. Further, the amount of ethyl alcohol added to the nitrocellulose solution is 2 : 1 to 1:10, preferably 1: 1 to 1: 7, more preferably 1: 2 to 1: 5, for the same reason. Here, the use of ethyl alcohol has a bactericidal effect on the ethyl alcohol itself, and after the target portion is sterilized, a sealing film is formed with nitrocellulose, so that the deodorizing effect is improved.
In order to improve the fluidity of the formulation and the toughness of the film after film formation, for the base made by adding ethyl alcohol to the nitrocellulose solution, perilla oil, sesame oil, sesame oil, olive oil, horse oil, Natural oils such as castor oil and hinoki oil may be blended, and the blending ratio of these natural oils is 0.01% to 20%, preferably 0.05 to 10%, more preferably 0.1% to 5%. Although it is good, this is also because it becomes difficult to form a sealed film if it is too much.
In addition, the antibacterial agents salicylic acid, menthol, mint oil, perilla extract, propolis, cinnamon extract (cinnamaldehyde), hinokitiol, isopropylmethyl, which are antibacterial agents incorporated in the formulation, to the extent that the sealed film formation of the formulation is not inhibited Phenol or the like may be blended, and for the same reason, 0.01% to 20%, preferably 0.05 to 10%, more preferably 0.1 to 5% can be blended freely.

Furthermore, methylsulfanylmethane (MSM), which is a sulfur compound, may be blended in the film preparation of this example. This is because MSM strengthens epithelial tissues such as skin, nasal mucosa, gastrointestinal tract, This is because it plays a role in strengthening the barrier against allergens, promotes collagen synthesis, and helps to create healthy skin. In addition, the MSM in the film preparation of this example forms a film as a crystal when a film is formed on the skin. When sweat is applied, the crystal dissolves by the sweat, resulting in the formation of ultrafine pores in the film. Therefore, it has an effect of preventing skin covering, and this makes it possible to use the preparation for a long time.
The blending ratio of the MSM to the film preparation is preferably 0.01% to 20%, preferably 0.05 to 10%, more preferably 0.1 to 5%. The formation of a hermetic film is not hindered.
Similarly, aluminum sulfate potassium, zinc oxide, kaolin, and plant extract, which are substances having a local astringent action, are 0.01% to 10%, preferably 0.05% to 5%, more preferably 0.1 to 3%. % Can be freely blended.

According to deodorizing film preparation of the present invention, methylbutyl acetate (isopentyl acetate), isobutyl acetate, or a single acetone, or volatilization nitrocellulose dissolved in a mixture is at body temperature with ethyl alcohol as a solvent, coating site After evaporation A 10 μm to 100 μm film is formed on the skin and the affected part (sweaty part) is covered to confine the odor emitted from the affected part, thereby exhibiting the deodorizing effect.
This effect of sealing the affected area results in an indirect deodorizing effect by suppressing the growth of the resident skin bacterium, which is the cause of odor generation, in order to avoid direct contact with air. Moreover, since ethyl alcohol itself has a bactericidal effect, it leads to a deodorizing effect as described above.
In addition to the characteristics of this formulation, antibacterial agents are added to the formulation to further enhance the bactericidal effect, and by adding a local astringent, sweat generation from sweat glands is suppressed, and the supply of odor raw materials and decomposition of them are performed. Deodorizing effect with a comprehensive effect of suppressing bacteria that generate odors.
In addition, the formulation features such as covering the affected area with an extremely thin transparent film can contaminate the hands, contaminate clothes and socks, and eliminate all the uncomfortable feelings (jukju sensation, cloudiness of the skin) of the affected area. It becomes possible. In addition, since it is a colorless and transparent very thin film layer that is in close contact with the skin, even if it is used on a part where the skin is exposed, it does not stand out even when viewed by others. However, even if it is translucent, the action and effect are the same as long as the skin can be seen through.
Furthermore, since the medicine in the affected area does not flow down due to daily bathing or showering, there is a reliable and continuous deodorizing effect.

[Example]
A preferred embodiment of the deodorizing film preparation of the present invention will be described. First, the blending ratio of this embodiment is as shown in the following [Table 1].

[Table 1] [Composition ratio]
Nitrocellulose ... 2.0%
Ethyl alcohol ... 55.0%
Isobutyl acetate: 20.0%
3-methylbutyl acetate: 10.0%
Methylsulfanylmethane ... 3.0%
Menthol ... 2.0%
Perilla extract ... 5.0%
Potassium aluminum sulfate ... 3.0%

[Adjustment method]
The deodorant film preparation of this example is prepared by the following procedure so that the composition ratio is as described above.
First, after nitrocellulose is dissolved in isobutyl acetate, isopentyl acetate is further added and stirred well. Next, after adding ethyl alcohol to this solution and stirring well, methylsulfanylmethane, menthol, perilla extract, and alum are added in small portions under sequential stirring and allowed to stand at room temperature for 24 hours for production.

[Odor control test]
The effect | action and effect of the deodorizing film formulation of the Example manufactured with said composition and the adjustment method were verified on the following conditions.
(1) Subject: Deodorant film preparation (Formulation in the above example: hereinafter referred to as “Example product”)
Control product: Ordinary commercially available deodorant cream (Combination of isopropylmethylphenol manufactured by Company C: hereinafter referred to as “comparative product”)
(2) Subjects: 5 adult volunteers (male 25-38 years old)
(3) Test method: Dosage, administration method and administration period
(A) After bathing on the first day of the test, the appropriate amount of the example product was applied to the starboard once, and the comparative product was applied to the left port, and after 5 minutes, each was covered with absorbent cotton (5 cm × 5 cm, double). Later, it was fixed with adhesive bandage. Thereafter, the absorbent cotton was sequentially replaced every 24 hours. The replaced cotton wool was sealed in a plastic bag, and used as a sensory test sample. Each formulation was limited to one application for the first time in principle.
(B) The test period is 7 days. During the test period, do not use any scents such as perfume and eau de cologne, and instruct each subject to refrain from taking foods that affect body odor such as garlic and leek. Thorough.

(4) Observation items: Absorbent cotton worn on both sides of the subject was taken out from the plastic bag, and the odor intensity was determined by three odor appraisers according to the following criteria.
Judgment was performed using an intermediate judgment result among the three appraisers.
(5) Odor degree criteria 3: Quite 2: Slight 1: Smell 0: Slightly odor 0: Almost no odor The above evaluation criteria and the experimental results are shown in Table 2 in FIG. It is.
(6) Odor improvement criteria
From the results of “Deodorization effect test results” in [Table 2], the odor improvement degree was determined in four stages according to the following criteria in principle.
Significant improvement (++): 3 → 0 2 → 0
Improvement (+): 3 → 2 3 → 1 2 → 1 1 → 0
Invariant (±): 3 → 3 2 → 2 1 → 1
Deterioration (-): Deterioration According to the above criteria, marked improvement (++), improvement (+), unchanged (±), and deterioration (-) are shown in [Deodorization improvement degree 1] in FIG. This is [Table 3], and this is expressed as the number of people in [Table 4] of [Deodorization improvement degree 1] in FIG. 3. Further, in order to clarify the comparison of the effect, the improvement ratio is expressed in%. This is expressed in [Table 5] of “improvement rate for each judgment day” in FIG.

(7) Feeling of use The ease of application of the preparation, the state after application, etc. were comprehensively judged, and the evaluation of this example for the comparative product was taken in a questionnaire format.
1: Very good. 2: Good. 3: No change. 4: Bad As a result, “1: very good” was 4, “2: good” was 1, “3: not changed” and “4: bad” were 0. That did this in the graph, a pie chart "feel" of the present embodiment product in comparison with comparative examples of FIG.

[Verification of test results]
The effect is verified from the test results.
It can be seen from the “improvement rate for each judgment day” in FIG. 4 [Table 5] of the final result created based on the results of “Deodorization effect test results” in [Table 2] in FIG. On the first day after application, 80% of the subjects showed “significant improvement” in the deodorizing film preparation, and maintained until 3 days thereafter, 60% from the 4th day to the 5th day, then 40% on the 6th day, 7th day. Although the rate of “significant improvement” gradually decreased with time of 20% over time, 100% was maintained during the test period above “improvement”.
On the other hand, in the commercial cream of the comparative example, “significant improvement” was observed only once from the first day after application, and thereafter no change was observed until the seventh day after the end of the test.
In addition, even if the rank was lowered and the comparative product was ranked “improvement” or higher, 100% was maintained from the first day to the third day after application, but it was reduced to 60% on the fourth day and 40% on the fifth day. However, it was 0% from the sixth day to the seventh day after the end of the test, and no deodorizing effect was observed.

From the above results, the example products of the deodorizing film preparation based on the present invention have a deodorizing effect that is far more reliable and superior in sustainability than the comparative example that is a cream preparation aiming at conventional deodorizing. It turns out that it is a formulation.
Furthermore, from the graph of FIG. 5, the results of the questionnaire on the feeling of use indicate that the example product of the deodorant film preparation is very good compared with the comparative example product of the conventional deodorant cream preparation, but 80% is good, but 20% is good Thus, it was clarified that the product of this example was far superior in usability than the commercially available comparative product in terms of usability.

  In addition, as long as the characteristics of the present invention are not impaired, the present invention is not limited to the above-described examples, and 3-methylbutyl acetate (isopentyl acetate), isobutyl acetate, or acetone may be used alone as a solubilizer. Alternatively, 3-methylbutyl acetate (isopentyl acetate), or isobutyl acetate, or acetone may be mixed. In order to improve the fluidity of the preparation and the toughness of the film after film formation, perilla oil, sesame oil, sesame oil Natural oils such as olive oil, horse oil, castor oil and cypress oil may be added, and antibacterial and / or bactericidal salicylic acid, menthol, mint oil, perilla seed extract, propolis, cinnamon extract (cinnamaldehyde) ), Natural or synthetic substances such as hinokitiol and isopropylmethylphenol may be added, Sulfur compounds such as tilsulfanyl methane (MSM) may be included, and potassium aluminium sulfate, zinc oxide, kaolin, plant extracts (hyperperum extract, horseshoe extract, maronier extract, grape leaf extract) that have local astringent action , Shinano extract, Hamamelis extract, cornflower extract, etc.) and the like.

It is a figure of Table 2 of the deodorization effect test result of an Example product and a comparative example product. It is a figure of Table 3 of the deodorization improvement degree 1 of an Example product and a comparative example product. It is a figure of Table 4 of the deodorization improvement degree 2 of an Example product and a comparative example product. It is a figure of Table 5 of the improvement rate for every judgment day of an example product and a comparative example product. It is the figure of the pie chart of the example product "usability" compared with the comparative example product.

Claims (8)

Nitrocellulose is dissolved in a solubilizer of 3-methylbutyl acetate, isobutyl acetate, acetone, or a mixture thereof, and further, ethyl alcohol is added to form a preparation. After application to the skin, the solvent evaporates. And a transparent or translucent film of nitrocellulose having a thickness of 10 μm to 100 μm is formed on the skin to seal the affected area and prevent the odor, foot, and other odors from spreading. .   2. The deodorant film preparation according to claim 1, wherein natural oil is added to the solubilizer to improve the fluidity of the preparation and the toughness of the film after the film is formed.   The deodorizing film preparation according to claim 2, wherein the natural oil is selected from perilla oil, sesame oil, sesame oil, olive oil, horse oil, castor oil, and hinoki oil.   Adding a natural or synthetic substance having antibacterial and / or bactericidal action selected from salicylic acid, menthol, mint oil, perilla extract, propolis, cinnamon extract, hinokitiol, isopropylmethylphenol into the preparation. The deodorizing film preparation according to claim 1, which is characterized by the following.   The deodorizing film preparation according to claim 1, wherein the preparation contains a sulfur compound.   6. The deodorizing film preparation according to claim 5, wherein the sulfur compound is methylsulfanylmethane.   2. The deodorizing film preparation according to claim 1, wherein the preparation contains a substance having a local convergence action.   The substance having a local astringent action is a substance selected from potassium sulfate, zinc oxide, kaolin, hypericum extract which is a plant extract, horse chestnut extract, maroonnier extract, grape leaf extract, shinano extract, hamameris extract, cornflower extract The deodorizing film preparation according to claim 7, wherein

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