JP4824933B2 - Cosmetics - Google Patents

Description

  The present invention relates to an agent effective for alleviating skin irritation caused by ingredients of cosmetics and a cosmetic containing the skin irritation mitigating agent, and more particularly to the use of cosmetics, particularly hair cosmetics such as hair dyes. The present invention relates to an agent effective for the generation of irritation in the scalp and the reduction or suppression of erythema symptoms, and a cosmetic containing such an agent and having improved usability and biosafety.

In recent years, the so-called dyeing of hair, which begins with gray hair dyeing, has been established as a fashion or makeup method, taking the place of mere gray hair concealment. The number of people undergoing treatment is spreading.
This hair dyeing can be broadly divided into three methods: permanent hair coloring lasting for about 1 to 2 months, semi-permanent hair coloring for about 2 to 3 weeks, and temporary hair color that fades after washing. And nowadays, among them, permanent hair dyeing has become mainstream.
Permanent hair dyeing is a method in which an oxidation dye consisting of a dye precursor such as paraphenylenediamine and a coupler such as resorcin is allowed to penetrate into the hair in the presence of alkali, and this is oxidatively polymerized with an oxidizing agent such as hydrogen peroxide. If the hair dye adheres to the scalp during treatment, depending on the subject, sensitization to the oxidation dye paraphenylenediamine may cause erythema, or paraphenylenediamine, alkalis, and more There are many cases in which irritation or pain caused by hydrogen peroxide used as an oxidizing agent is felt, and various methods for improving this point have been studied.
As one of them, from the viewpoint that the occurrence of erythema and irritation is one of the inflammatory symptoms, attempts have been made to add an anti-inflammatory component to the hair dye, but the effect as expected is obtained. It has not reached. Further, in JP-A-8-81327, as a method for alleviating skin irritation in general, an external preparation for skin application, by using rice germ oil as a base of the application agent, and forming a protective film on the skin surface, It has been disclosed to protect sensitive skin from external irritation, and further, JP-A-2000-363953 proposes a stimulating agent for hair dyes comprising rice germ oil and azulene. However, it cannot be said that the stimulus mitigation effect obtained by these methods or agents can still be sufficiently satisfied.

JP-A-8-81327 JP 2000-363953 A

  The present invention has been made in view of the above-mentioned problems seen in the use of cosmetics, particularly hair cosmetics such as hair dyes. The object of the present invention is cosmetics, particularly hair dyes, etc. It is an object of the present invention to provide an agent effective for alleviating or suppressing skin irritation and erythema caused by the ingredients of hair cosmetics, and a cosmetic containing such an agent and having excellent usability and biosafety. Another object of the present invention is to provide a skin irritation relieving agent comprising a natural product-derived component, which itself does not exhibit irritation to the skin and has high biosafety, and a cosmetic comprising the same.

That is, the present invention firstly uses a proteolytic enzyme- treated product of an extract obtained by extracting red rice bran (excluding red rice cake of pigmented rice) with an acidic aqueous medium having a pH of 1 to 4. It relates to a skin irritation relieving agent. Secondly, the present invention relates to a hair dye containing the above-mentioned skin irritation relieving agent .
In the present invention, the term cosmetic is used in a broad sense including so-called cosmetics and quasi-drugs.

When the skin irritation mitigating agent comprising the rice bran extract of the present invention as an active ingredient is blended in cosmetics, particularly hair cosmetics such as hair dyes, skin irritation and erythema symptoms caused by stimulating substances in the cosmetic ingredients Is alleviated or suppressed, the feeling of use of the cosmetic is improved, and the safety to the skin is also improved. In addition, when this rice bran extract is hydrolyzed by proteolytic enzymes, the resulting hydrolyzate not only shows the same high skin irritation mitigating action as rice bran extract, but also decreases the effectiveness over time. And excellent storage stability with little change in properties.
Further, the skin irritation mitigating agent of the present invention may have an adverse effect such as irritation on the skin itself, because the active ingredient rice bran extract or its hydrolyzate may be derived from natural products. It is extremely safe.

Hereinafter, the present invention will be described in detail.
The rice bran extract used as an active ingredient in the skin irritation mitigating agent of the present invention is obtained by extracting with a solvent a so-called red rice bran composed mainly of a brown rice surface layer and germs produced during the process of scouring brown rice into refined rice. It is.
This rice bran is desirably subjected to enzyme deactivation treatment or degreasing treatment by heating from the viewpoint of storage stability or ease of handling.
As the extraction method, an immersion method, a countercurrent extraction method, or the like is used. In some cases, a supercritical extraction method may be used.

As an extraction solvent, water; lower alcohols such as methanol, ethanol, and propanol; higher alcohols such as oleyl alcohol, stearyl alcohol, and octyldodecanol; many solvents such as ethylene glycol, propylene glycol, 1,3-butylene glycol, and glycerin Monohydric alcohols; esters such as ethyl acetate, butyl acetate and methyl propionate; ketones such as acetone and methyl ethyl ketone; ethers such as ethyl ether and isopropyl ether; hydrocarbon solvents such as n-hexane, toluene and chloroform; These may be used alone or in admixture of two or more.
Among these extraction solvents, from the viewpoint of the skin irritation mitigating effect of the extract obtained, and easy to shift to the treatment process when subjecting the extract to the hydrolysis treatment described later, it can be widely applied to cosmetics In view of the above, it is preferable to use an aqueous medium, particularly water or a mixed solvent of water and a lower alcohol or a polyhydric alcohol, and most preferable to use water alone.
In the case of using a mixed solvent, the mixing ratio of lower alcohols and polyhydric alcohols to water is generally 70% by weight or less, and particularly preferably 50% by weight or less.

At the time of extraction, the pH of the extract may be any of acidic region, neutral region or alkaline region, and in any case, an extract having a skin irritation mitigating effect can be obtained. Extraction is preferably performed under such acidic conditions because it is most prominently observed in the extract obtained when the pH is 5 or less, particularly 1 to 4.
When performing extraction under acidic conditions, examples of acids used for pH adjustment include inorganic acids such as hydrochloric acid, sulfuric acid, and phosphoric acid, and organic acids such as acetic acid, malic acid, and citric acid. However, the use of lactic acid is most preferred.

  Extraction conditions such as extraction temperature and time vary depending on the type of solvent used, pH, and the like. For example, in the case of the immersion method, the extraction temperature is generally in the range of 1 to 80 ° C., preferably 2 to 40 ° C. The extraction time is generally 1 hour to 7 days in the case of room temperature extraction, preferably 15 to 30 hours, and generally 30 minutes to 24 hours in the case of warm extraction at 80 ° C., preferably 1 to 6 hours. Range.

When the extraction is completed, a solution containing the desired rice bran extract is obtained by applying solid-liquid separation means such as filtration and centrifugation to remove the extraction residue.
The rice bran extract obtained here has excellent relief or suppression action against skin irritation and erythema symptoms caused by irritating substances in cosmetic ingredients, and is useful as an active ingredient of skin irritation relieving agent It is.
In addition, when this rice bran extract is further hydrolyzed, the resulting hydrolyzate is in no way inferior to the extract in stimulating or suppressing action, while maintaining the quality and stability during long-term storage. In the present invention, it is particularly preferable to use such a hydrolyzate because it is superior to the extract.

The hydrolysis treatment can be carried out using an acid such as hydrochloric acid, sulfuric acid or phosphoric acid, or an alkali such as sodium hydroxide or potassium hydroxide, but a homogeneous hydrolyzate can be obtained with good reproducibility. Therefore, it is most preferable to use a proteolytic enzyme.
When hydrolyzing using a proteolytic enzyme, examples of the proteolytic enzyme include actinases such as actinase, pepsins such as pepsin, trypsins such as trypsin and chymotrypsin, papains such as papain and chymopapain, and glycyl. Examples thereof include peptidases such as glycine peptidase, carboxypeptidase and aminopeptidase, bromelain and the like, and these may be used alone or in combination of two or more.
Among these enzymes, actinases such as actinase, papains such as papain and chymopapain, and bromelain are particularly preferable.

Proteolytic enzyme treatment is carried out by adding one or more of the above enzymes to the rice bran extract solution, and carrying out the enzyme reaction under conditions near the optimum pH and temperature of the enzyme used. The When two or more kinds of enzymes are used in combination, two or more kinds of enzymes may be allowed to act simultaneously according to the characteristics of the enzyme used, or may be allowed to act sequentially without changing or changing the reaction conditions. .
The amount of the enzyme used is preferably in the range of 0.001 to 50 parts by weight, more preferably 0.1 to 10 parts by weight per one enzyme with respect to 100 parts by weight of the solid content of the rice bran extract solution. Range. The enzyme treatment time varies depending on the type of enzyme used and the like, but is generally in the range of 0.5 to 24 hours, preferably in the range of 1 to 6 hours.
In addition, the proteolytic enzyme treatment described above may be performed simultaneously with the extraction treatment, which is the previous step, in some cases.
Thus, when the treatment with the proteolytic enzyme is completed, the rice bran extract hydrolyzate having good storage stability can be obtained by inactivating the enzyme using an appropriate method such as heating the enzyme treatment solution to 80 ° C. or higher. A solution is obtained.

  The above-described rice bran extract solution or the hydrolyzate solution obtained here may generally be adjusted to a pH of 4 to 8 and then directly added to a cosmetic as a skin irritation mitigating agent. You may mix | blend with cosmetics adjusted to the predetermined density | concentration by vacuum concentration etc. In some cases, powders prepared by conventional methods such as spray drying and freeze drying can be blended in cosmetics as a skin irritation relieving agent.

Cosmetics that are particularly effective when blended with the skin irritation mitigation agent of the present invention prepared as described above are hair cosmetics such as hair dyes, hair treatments, hair nicks, hair growth / hair restorations, hair shampoos, hair rinses, etc. However, the cosmetics to which the skin irritation mitigation agent of the present invention is blended are not limited to these hair cosmetics, of course, in addition to emulsions, creams, lotions, Basic cosmetics such as essences and packs; makeup cosmetics such as lipsticks, foundations, liquid foundations, and makeup press powders; cleansing cosmetics such as facial cleansers, body shampoos, and soaps; .
In addition, when trying to relieve or suppress the scalp irritation and inflammatory symptoms seen when applying a hair dye, the skin irritation relieving agent of the present invention may be blended directly into the hair dye. Moreover, the stimulation by the hair dye may be alleviated by applying a lotion or the like containing the skin irritation reducing agent of the present invention to the scalp prior to the hair dye treatment.

The blending amount of the skin irritation agent of the present invention into the cosmetic differs depending on the cosmetic formulation (component composition), application, etc., and cannot be generally specified. Generally, however, the active ingredient rice bran extract or its hydrolyzate In terms of solid content, it is in the range of 0.001 to 10% by weight, preferably in the range of 0.002 to 5% by weight. From this range, a suitable blending amount is selected according to the prescription and use of cosmetics. The For example, in the case of a permanent hair dye, the blending amount is preferably 0.002 to 1% by weight, particularly 0.02 to 0.2% by weight, in terms of solid content of rice bran extract or its hydrolyzate. Is good.
In addition, in the case of a lotion or the like used for prior irritation treatment as shown in the example of the hair dye, the amount of the skin irritation mitigation agent of the present invention should be about 2 to 5 times the above amount. Is preferred.

  In addition to the above-mentioned skin irritation relieving agents, the cosmetics of the present invention include components usually used in cosmetics, such as oily components, surfactants, moisturizers, thickeners, antiseptic / disinfectants, powder components, An ultraviolet absorber, an antioxidant, a hair dye component, a physiologically active component, a pigment, a fragrance, and the like are appropriately blended as necessary.

  Here, as the oil component, for example, olive oil, jojoba oil, castor oil, soybean oil, rice oil, rice germ oil, palm oil, palm oil, cacao oil, meadow foam oil, sheer butter, tea tree oil, avocado oil, Oils derived from plants such as macadamia nut oil and plant-derived squalane; Fats derived from animals such as mink oil and turtle oil; waxes such as beeswax, carnauba wax, rice wax, lanolin; liquid paraffin, petrolatum, paraffin wax, squalane, etc. Hydrocarbons; fatty acids such as myristic acid, palmitic acid, stearic acid, oleic acid, isostearic acid, cis-11-eicosenoic acid; higher alcohols such as lauryl alcohol, cetanol, stearyl alcohol; isopropyl myristate, palmitic acid Isopropyl, me Butyl phosphate, 2-ethylhexyl glycerides, higher fatty acid octyldodecyl (octyl stearate dodecyl and the like), and the synthetic esters and synthetic triglycerides such like.

Examples of the surfactant include polyoxyethylene alkyl ether, polyoxyethylene fatty acid ester, polyoxyethylene sorbitan fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyoxyethylene hydrogenated castor oil, polyoxyethylene Nonionic surfactants such as oxyethylene sorbitol fatty acid esters; fatty acid salts, alkyl sulfates, alkylbenzene sulfonates, polyoxyethylene alkyl ether sulfates, polyoxyethylene fatty amine sulfates, polyoxyethylene alkyl phenyl ether sulfates, Polyoxyethylene alkyl ether phosphates, α-sulfonated fatty acid alkyl ester salts, polyoxyethylene alkyl phenyl ether phosphates Quaternary ammonium salt, primary to tertiary fatty amine salt, trialkylbenzylammonium salt, alkylpyridinium salt, 2-alkyl-1-alkyl-1-hydroxyethylimidazolinium salt, N Cationic surfactants such as N, N-dialkylmorphonium salt, polyethylene polyamine fatty acid amide salt; N, N-dimethyl-N-alkyl-N-carboxymethylammoniobetaine, N, N, N-trialkyl-N- Amphoteric surfactants such as alkylene ammoniocarboxybetaine and N-acylamidopropyl-N ′, N′-dimethyl-N′-β-hydroxypropylammoniosulfobetaine can be used.
In addition, as emulsifiers or emulsifiers, stevia derivatives such as enzyme-treated stevia, lecithin and derivatives thereof, lactic acid bacteria fermented rice, lactic acid bacteria fermented rice, lactic acid bacteria fermented cereals (wheat, beans, millet, etc.), juzyiro (Rhamnaceae) ) An extract or the like can also be blended.

  Examples of the humectant include glycerin, propylene glycol, dipropylene glycol, 1,3-butylene glycol, polyethylene glycol, sorbitol, xylitol, sodium pyrrolidonecarboxylate, and sugars such as trehalose and maltose, lactic acid bacteria fermented rice, mucos Polysaccharides (eg, hyaluronic acid and its derivatives, chondroitin and its derivatives, heparin and its derivatives, etc.), elastin and its derivatives, collagen and its derivatives, hydrolyzed silk protein, NMF related substances, lactic acid, urea, higher fatty acid octyldodecyl Phytosterol, soybean phospholipid, cholesteryl isostearate, seaweed extract, seafood-derived collagen and its derivatives, various amino acids and their derivatives (for example, trimethylglycine) It is below.

  Examples of thickeners include, for example, brown algae such as alginic acid, agar, carrageenan, fucoidan, green algae or red algae-derived components, beech extract, pectin, locust bean gum, polysaccharides such as aloe polysaccharide, xanthan gum, tragacanth gum, guar gum, etc. Synthetic polymers such as gums, cellulose derivatives such as carboxymethylcellulose, hydroxyethylcellulose, polyvinyl alcohol, polyvinylpyrrolidone, carboxyvinyl polymer, acrylic acid / methacrylic acid copolymer; hyaluronic acid and its derivatives, polyglutamic acid and its derivatives, etc. Is mentioned.

  Examples of the antiseptic / bactericidal agent include urea; paraoxybenzoates such as methyl paraoxybenzoate, ethyl paraoxybenzoate, propyl paraoxybenzoate, butyl paraoxybenzoate; phenoxyethanol, dichlorophene, hexachlorophene, chlorhexidine hydrochloride, benzaza chloride Luconium, salicylic acid, ethanol, undecylenic acid, phenols, jamal (imidazodenyl urea), 1,2-pentanediol, various essential oils, bark dry matter, and the like.

  Examples of powder components include sericite, titanium oxide, talc, kaolin, bentonite, zinc oxide, magnesium carbonate, magnesium oxide, zirconium oxide, barium sulfate, anhydrous silicic acid, mica, 6- or 12-nylon powder, polyethylene powder Silk powder, cellulosic powder, grains (rice, wheat, corn, millet, etc.) powder, beans (soybean, red beans, etc.) powder, and the like.

  Examples of the ultraviolet absorber include ethyl paraaminobenzoate, ethylhexyl paradimethylaminobenzoate, octyl paradimethylaminobenzoate, amyl salicylate and derivatives thereof, octyl salicylate, homomenthyl salicylate, 2-ethylhexyl paramethoxycinnamate, octyl paramethoxycinnamate, Octyl cinnamate, oxybenzone, 2,4-dihydroxybenzophenone, tetrahydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, 4-tertiarybutyl-4-methoxybenzoylmethane, 2- (2-hydroxy -5-methylphenyl) benzotriazole, urocanic acid, ethyl urocanate, aloe extract and the like.

  Antioxidants include, for example, butylhydroxyanisole, butylhydroxytoluene, propyl gallate, vitamin E and its derivatives, ubidecaquinone (ubiquinone), rutin, rutin glucoside, white coconut extract, rice extract, murasakikibu extract, birch extract Products, Hamelis extract, oolong tea extract and the like.

  Examples of the hair dye component include oxidation dyes such as p-phenylenediamine, p-aminophenol, 0-aminophenol and toluene-2,5-diamine, couplers such as m-phenylenediamine and m-aminophenol. .

Examples of physiologically active ingredients include whitening ingredients such as t-cycloamino acid derivatives, kojic acid and its derivatives, hydroquinone derivatives, ellagic acid and its derivatives, resorcinol derivatives, placenta extract, cysteine, Sakuhakhi extract, yukinoshita extract, rice bran Extract, rice bran extract hydrolyzate, lactic acid bacteria fermented rice, lactic acid bacteria fermented germinated rice, lactic acid bacteria fermented cereals (barley, beans, millet), white coconut hydrolyzed extract, murasakixikib extract, lotus fruit ferment Extract, Pandanus amaryllifolius Roxb. Extract, Arcangelicia flava Merrilli extract, Chamomile extract (trade name: Chamomile ET), Ginkgo biloba extract Seaweed extract such as extract, Sahby foliage extract, licorice extract, licorice poppo extract, artea extract, geno shoko extract, cypress extract, jujube extract, peonies extract, suzuki extract, peach extract, kombu Extracts of seaweed such as sea cucumber, linoleic acid and its derivatives or processed products (eg liposomal linoleic acid), 2,5-dihydroxybenzoic acid derivatives, etc. are derived from animals or fish as skin aging prevention / beautification components Collagen and derivatives thereof, elastin and derivatives thereof, intercellular lipids such as ceramide, placental extract, nicotinic acid and derivatives thereof, glycyrrhizic acid and derivatives thereof (dipotassium salt, etc.), t-cycloamino acid derivatives, vitamin A and derivatives thereof , Vitamin E and its derivatives, allantoin, α-hydroxy acids, di Herbal extracts such as sopropylamine dichloroacetate, γ-amino-β-hydroxybutyric acid, coenzyme Q-10, α-lipoic acid, gentian extract, licorice extract, pearl barley extract, chamomile extract, carrot extract, aloe extract, cuckoo extract , Rice extract hydrolyzate, rice bran extract hydrolyzate, rice fermented extract, beetroot extract, anaaaosa extract, seaweed extract such as sea cucumber, soup extract, zizyphus juazeiro extract, beech extract, Kidachi aloe extract, Mannen wax extract, Ginkgo biloba extract, Horsetail extract, Safflower extract, Panax ginseng extract, Carrot extract, Elderberry extract, Scarlet moth extract, Black bean extract, Mango extract, Cherimoya extract, Mangosteen Extraction , Tabebuia intiginosa extract, yeast extract, eggshell membrane extract protein, deoxyribonucleic acid potassium salt, etc., and as a hair growth / hair-growing component, female hormones such as ethinyl estradiol and estrone, anti-oxidants such as minoxidil and clove extract Cell activation or blood circulation promoters such as male hormones, carpronium chloride, pentadecanoic acid glyceride, hinokitiol, etc., blood circulation promoters such as assembly extract, gentian extract, chamomile extract, cephalanthin, vitamin E and its derivatives, salicylic acid, dipotassium glycyrrhizinate (licorice) Extract), antibacterial and anti-inflammatory agents such as pyridoxine hydrochloride (vitamin B ₆ ), and sebum adjusters.

  Examples of the kojic acid derivatives include kojic acid esters such as kojic acid monobutyrate, kojic acid monocaprate, kojic acid monopalmitate, kojic acid dibutyrate, kojic acid ethers, kojic acid sugar derivatives such as kojic acid glucoside, etc. As the ascorbic acid derivatives, for example, L-ascorbic acid-2-phosphate sodium, L-ascorbic acid-2-phosphate magnesium, L-ascorbic acid-2-sulfate sodium, L-ascorbic acid-2 -Ascorbic acid ester salts such as magnesium sulfate, L-ascorbic acid-2-glucoside (2-O-α-D-glucopyranosyl-L-ascorbic acid), L-ascorbic acid-5-glucoside (5-O-α) -D-Glucopyranosyl-L-ascorbine Acid) ascorbic acid sugar derivatives, acylated 6-positions of these ascorbic acid sugar derivatives (acyl groups are hexanoyl, octanoyl, decanoyl, etc.), L-ascorbic acid tetraisopalmitate, L-ascorbic acid tetra L-ascorbic acid tetra-fatty acid esters such as lauric acid ester, 3-O-ethylascorbic acid, L-ascorbic acid-2-phosphate-6-O-palmitate sodium, etc. include arbutin (hydroquinone) -Β-D-glucopyranoside), α-arbutin (hydroquinone-α-D-glucopyranoside) and the like, and as the resorcinol derivative, for example, 4-n-butylresorcinol, 4-isoamylresorcinol and the like are 2,5-dihydroxybenzoic acid. Derivatives and For example, 2,5-diacetoxybenzoic acid, 2-acetoxy-5-hydroxybenzoic acid, 2-hydroxy-5-propionyloxybenzoic acid, etc., and nicotinic acid derivatives include, for example, nicotinic acid amide, benzyl nicotinate, etc. However, examples of vitamin E derivatives include vitamin E nicotinate and vitamin E linoleate, and examples of α-hydroxy acids include lactic acid, malic acid, succinic acid, citric acid, and α-hydroxyoctanoic acid.

  Furthermore, an anti-inflammatory component or the like may be combined and blended within a range that does not impair the effectiveness and features of the skin irritation relieving agent of the present invention, and examples thereof include azulene such as sodium guaiazulenesulfonate and ethyl guaiazulenesulfonate. Derivatives, glycyrrhizic acid derivatives such as dipotassium glycyrrhizinate, stearyl glycyrrhizinate, allantoin, licorice extract, cucumber extract, peonies extract, button pipi extract, forsythia extract, ryutan extract, Tokinsenka extract, parsley extract, Examples include Hypericum extract, Bakuryotake extract, Cassia extract and the like.

  Next, the present invention will be described more specifically with reference to examples, formulation examples (cosmetic examples), and test examples, but the present invention is not limited thereto. In the following, all parts are parts by weight, and all% are% by weight.

Example 1. Preparation of skin irritation relieving agent (1)
After adding 1200 g of 0.1M lactic acid aqueous solution (pH 2.6) to 400 g of rice bran, the mixture was stirred and mixed, and then allowed to stand at room temperature for 2 days. Next, the insoluble matter is removed by filtration, the pH of the filtrate is adjusted to 8.5 with 1N aqueous sodium hydroxide solution, and the resulting precipitate is filtered off. The filtrate is adjusted to pH 6.5 with lactic acid and consists of a rice bran extract solution. 800 g of skin irritation relieving agent was obtained (solid content concentration 4.4%).

Example 2 Preparation of skin irritation relieving agent (2)
800 g of rice bran extract solution obtained in the same manner as in Example 1 was adjusted to about pH 7 with 1N sodium hydroxide, and 20 mg of proteolytic enzyme (papain) was added and hydrolyzed at 40 ° C. for 3 hours. Subsequently, the enzyme was inactivated by heating to 80 ° C., and after cooling to room temperature, filtration was performed to obtain 750 g of a skin irritation alleviation agent comprising a rice bran extract hydrolyzate solution (solid content concentration 4.7%).

Example 3 Preparation of skin irritation relieving agent (3)
In the same manner as in Example 1 except that 10% ethanol-containing 0.1M lactic acid aqueous solution (pH 2.7) was used as the extraction solvent instead of 0.1M lactic acid aqueous solution, Obtained (solid content concentration 5.2%).

Example 4 Preparation of skin irritation relieving agent (4)
After adding 1200 g of 0.1M phosphoric acid aqueous solution (pH 1.6) to 400 g of rice bran, the mixture was allowed to stand at room temperature for 2 days. Next, the insoluble matter was removed by filtration, the pH of the filtrate was adjusted to 8.5 with a 1N aqueous sodium hydroxide solution, and the resulting insoluble matter was filtered off to obtain 700 g of rice bran extract solution (solid content concentration: 4. 4%). This rice bran extract solution was adjusted to about pH 8 with sodium hydroxide, 0.14 g of protease (actinase) was added, and the mixture was hydrolyzed at 40 ° C. for 2 hours. Subsequently, it heated to 80 degreeC, the enzyme was deactivated, it cooled to room temperature, and it filtered, and obtained the skin irritation relaxation agent 650g which consists of a rice bran extract hydrolyzate solution (solid content concentration 4.7%).

Example 5 FIG. Preparation of skin irritation relieving agent (5)
After adding 1200 g of purified water to 400 g of rice bran, the pH was adjusted to around 7 with a 1N aqueous sodium hydroxide solution, and then allowed to stand at room temperature for 2 days. Next, insoluble matter was removed by filtration to obtain 800 g of a skin irritation relieving agent comprising a rice bran extract solution (solid content concentration 4.6%).

Example 6 Preparation of skin irritation relieving agent (6)
800 g of the rice bran extract solution obtained in the same manner as in Example 5 was adjusted to about pH 8 with 1N aqueous sodium hydroxide solution, 0.16 g of protease (actinase) was added, and the mixture was hydrolyzed at 40 ° C. for 2 hours. Next, the enzyme is inactivated by heating to 80 ° C., cooled to room temperature and filtered, and the precipitate formed by adjusting the filtrate to pH 6.5 with lactic acid is separated by filtration, and consists of a rice bran extract hydrolyzate solution. 750 g of skin irritation relieving agent was obtained (solid content concentration 4.8%).

Example 7 Preparation of skin irritation relieving agent (7)
After adding 1200 g of 0.1N sodium hydroxide aqueous solution to 400 g of rice bran and stirring and mixing, the mixture was allowed to stand at room temperature for 2 days. Next, the insoluble matter was removed by filtration, and the precipitate formed by adjusting the filtrate to pH 6.5 with lactic acid was filtered off to obtain 750 g of a skin irritation alleviating agent comprising a rice bran extract solution (solid content concentration 4.9). %).

Example 8 FIG. Preparation of skin irritation relieving agent (8)
750 g of rice bran extract solution obtained in the same manner as in Example 7 was adjusted to about pH 8 with 1N aqueous sodium hydroxide solution, and 0.15 g of protease (actinase) was added and hydrolyzed at 40 ° C. for 2 hours. Next, the enzyme is inactivated by heating to 80 ° C., cooled to room temperature and filtered, and the precipitate formed by adjusting the filtrate to pH 6.5 with lactic acid is separated by filtration, and consists of a rice bran extract hydrolyzate solution. Obtained 700 g of skin irritation relieving agent (solid content concentration 4.8%)

Example 9 Preparation of skin irritation relieving agent (9)
100 g of a rice bran extract hydrolyzate solution obtained in the same manner as in Example 2 was concentrated under reduced pressure and then freeze-dried to obtain 4.7 g of a skin irritation alleviating agent comprising a rice bran extract hydrolyzate powder.

成分１と成分４〜１０を均一に混合し撹拌した後、これに成分２及び３を加えて撹拌し、第１剤を得た。
［第２剤］
処方例１〜５に共通する第２剤として、３０％過酸化水素水２０．０部、精製水８０．０部及び適量の安定化剤からなる液を調製した。
上記の第１剤と第２剤は、施術の直前にそれぞれ適量を混合し、染毛剤として使用する。 Formulation Examples 1 to 5 Hair dye [First liquid]
A first hair dye having the composition shown in Table 1 was prepared.

Components 1 and 4 to 10 were uniformly mixed and stirred, and then components 2 and 3 were added and stirred to obtain a first agent.
[Second agent]
As a second agent common to Formulation Examples 1 to 5, a liquid comprising 20.0 parts of 30% hydrogen peroxide water, 80.0 parts of purified water and an appropriate amount of stabilizer was prepared.
Said 1st agent and 2nd agent mix each appropriate amount just before a treatment, and use it as a hair dye.

Formulation Example 6 Hair dye [first agent]
[Component A] Part Skin irritation relieving agent of Example 1 2.5
Oleic acid 20.0
Polyoxyethylene (10) oleyl alcohol ether 15.0
Infranc-AT (Note) 2.5
Isopropyl alcohol 10.0
28% ammonia water 10.0
Purified water Total amount of 100 parts Antioxidant Appropriate amount Chelating agent Appropriate amount (Note) Gentianana extract (Technoble Co., Ltd .; solid content concentration 3.0%)
[B component]
Paraphenylenediamine 3.0
Resorcin 0.5
After mixing and stirring A component uniformly, B component was added and stirred to this, and the 1st agent was obtained.
[Second agent]
20.0 parts of 30% hydrogen peroxide water, 80.0 parts of purified water and an appropriate amount of stabilizer were mixed to form a second agent.
Said 1st agent and 2nd agent mix each appropriate amount just before a treatment, and use it as a hair dye.

Formulation Example 7 Lotion [component] part skin irritation relieving agent of Example 2 5.0
Ethanol 10.0
Glycerin 3.0
1,3-butylene glycol 2.0
Infranc-AT 10.0
Napolein (Note) 10.0
Methylparaben 0.2
Citric acid 0.1
Sodium citrate 0.3
Carboxyvinyl polymer 0.1
Perfume Appropriate amount Potassium hydroxide Appropriate amount Purified water Amount to make 100 parts in total
(Note) Seaweed extract (Technoble Co., Ltd .; solid content concentration 1.5%)
The above ingredients were mixed to obtain a lotion.
This lotion is applied to the scalp before the hair dye treatment.

Formulation Example 8 Hair artic [component A] part ethanol 60.0
l-Menthol 0.5
Fragrance 0.1
Methylparaben 0.1
[B component]
Glycerin 2.0
1,3-butylene glycol 2.0
Skin irritation relieving agent of Example 3 5.0
Purified water in an amount of 100 parts The above A component and B component were each dissolved at room temperature, then the B component was added to the A component with stirring and dissolved to obtain a hair-tonic.

Formulation Example 9 Hair treatment [ingredient] part stearyltrimethylammonium chloride 6.0
Polyvinylpyrrolidone 4.0
Glycerin 1.0
Ethylparaben 0.1
Skin irritation relieving agent of Example 4 5.0
Purified water in a total amount of 100 parts The above ingredients were heated to 80 ° C and then mixed and stirred to obtain a hair treatment.

Formulation Example 10 Hair shampoo [component A] part N-coconut oil fatty acid methyl taurine sodium 10.0
Polyoxyethylene (3) sodium alkyl ether sulfate 20.0
Lauryldimethylaminoacetic acid betaine 10.0
Palm oil fatty acid diethanolamide 4.0
Methylparaben 0.1
[B component]
Citric acid 0.1
Skin irritation relieving agent of Example 5 5.0
1,3-butylene glycol 2.0
Purified water Amount to be 100 parts A component and B component are each heated to 80 ° C and dissolved uniformly, then B component is added to A component, and stirring is continued to cool to room temperature to obtain a hair shampoo It was.

Formulation Example 11 Hair rinse [component A] Part Polyoxyethylene (10) hydrogenated castor oil 1.0
Distearyldimethylammonium chloride 1.5
Stearyltrimethylammonium chloride 2.0
Glyceryl 2-ethylhexanoate 1.0
Cetanol 3.2
Stearyl alcohol 1.0
Methylparaben 0.1
[B component]
Skin irritation relieving agent of Example 6 5.0
1,3-butylene glycol 5.0
Purified water Amount to be 100 parts A component and B component are each heated to 80 ° C and dissolved uniformly, then B component is added to A component and stirring is continued to cool to room temperature to obtain hair rinse It was.

Formulation Example 12. Lotion [component A] part olive oil 1.0
Polyoxyethylene (5.5) cetyl ether 0.5
Butylparaben 0.1
[B component]
Skin irritation relieving agent of Example 7 5.0
Ethanol 5.0
Glycerin 5.0
1,3-butylene glycol 5.0
Methylparaben 0.1
Potassium hydroxide appropriate amount Purified water Amount that makes 100 parts in total
[C component]
Perfume
After each component A and component B was heated to 80 ° C. or higher, the component B was added to the component A and stirred, and further homogenized with Hiscotron (5000 rpm) for 2 minutes.
After cooling this to 50 degreeC, C component was added and stirred and mixed, and also it cooled to 30 degrees C or less, and the lotion was obtained.

Example 13 Lotion [component] part skin irritation relieving agent of Example 8 5.0
L-ascorbic acid-2-glucoside 2.0
Ethanol 10.0
Glycerin 3.0
1,3-butylene glycol 2.0
Methylparaben 0.2
Citric acid 0.1
Sodium citrate 0.3
Sodium alginate 0.1
Potassium hydroxide appropriate amount Perfume appropriate amount
Amount of purified water totaling 100 parts
The above ingredients were mixed to obtain a lotion.

Example 14 Soap [component A] part hardened castor oil 26.0
Coconut oil 10.0
Olive oil 4.0
[B component]
Sodium hydroxide 6.0
Sugar 10.0
Glycerin 5.0
Skin irritation relieving agent of Example 9 0.25
Purified water Amount of 100 parts [component C]
Ethanol 20.0
Perfume Appropriate A component and B component were each heated to 80 ° C. and dissolved uniformly, and then B component was added to A component to saponify. This was cooled to 50 ° C. with stirring, and component C was added. This was poured into a mold and cooled, and then dried at room temperature for several days. A sufficiently dried product was taken out from the mold to obtain soap.

Test Example 1 Skin irritation test About the hair dye containing the skin irritation reducing agent of this invention, the irritation reducing effect was investigated by the patch test.
[sample]
(1) Hair dye of Formulation Examples 1 to 5 (mixed liquid of each first agent and second agent in Table 1)
(2) Hair dye of Comparative Formulation Example 1: In the composition of the hair dye of Formulation Example 1 (mixture of the first agent and the second agent), instead of the skin irritation relieving agent of Example 2 of the first solution A hair dye having the same composition as the hair dye of Formulation Example 1 except that purified water is used.
(3) Hair dye of Comparative Formulation Example 2: In the composition of the hair dye of Formulation Example 5 (mixture of the first agent and the second agent), instead of the skin irritation relieving agent of Example 2 of the first solution A hair dye having the same composition as the hair dye of Formulation Example 5 except that purified water is used.

[Test method]
Five males aged 18 to 50 years were used as subjects, and the test section (2 mm × 2 mm) provided on one of the inner forearms of both arms was used in the test section (2 mm). × 2 mm) was patched with the hair dye of Comparative Formulation Example 1 and left for 30 minutes, and then the patch was removed. The irritation (pain / itch) in the patch was compared for the hair dye of Formulation Example 1 and the hair dye of Comparative Formulation Example 1, and scored according to the following criteria. In addition, the state of erythema immediately after the removal of the patch was similarly compared and scored according to the following criteria.
After the completion of the above test, the same tests were sequentially performed on the hair dyes of Formulation Examples 2 to 5 with a test interval of 3 days. In this case, for the hair dyes of Formulation Examples 2 to 4, the hair dye of Comparative Formulation Example 1 is used, and for the hair dye of Formulation Example 5, the hair dye of Comparative Formulation Example 2 is used as a comparative sample. It was.
[Evaluation criteria]
(Pain / itchiness)
4: No difference from the comparative prescription example 3: Little difference from the comparative prescription example 2: Slightly less irritation than the comparative prescription example 1: Very little irritation compared to the comparative prescription example 0: Compared with the comparative prescription example Obviously less irritating (erythema)
4: There is no difference from the comparative prescription example 3: There is almost no difference from the comparative prescription example 2: The erythema is somewhat inconspicuous compared with the comparative prescription example 1: The corresponding erythema is not conspicuous compared with the comparative prescription example 0: Comparative prescription example Erythema is clearly less noticeable than

注）Ａ〜Ｅは５名の被験者を示す [result]
The results are shown in Table 2.

Note) A to E indicate 5 subjects

  From the results in Table 2, it can be seen that the hair dye containing the skin irritation reducing agent of the present invention has an excellent irritation reducing effect in the patch test.

Test Example 2 Monitor test [sample]
(1) Hair dye of Formulation Example 1 (mixture of first and second agents)
(2) Hair dye of Comparative Formulation Example 1 (same as Test Example 1) (mixture of first and second agents)

[Test method]
Twenty randomly selected women aged 18 to 50 were used as subjects, and each sample was applied with a half head. After standing at room temperature for 30 minutes, the hair was rinsed with water and dried with a dryer. The scalp irritation feeling of the hair dye of Formulation Example 1 during application was compared with that of the hair dye of Comparative Formulation Example 1, and scored according to the same criteria as in Test Example 1. In addition, the state of erythema after 30 minutes of application was also comparatively observed and scored according to the same criteria as in Test Example 1. The score value was expressed as the average of 20 subjects.

[result]
The results are shown in Table 3.

  From the results in Table 3, it can be seen that the hair dye containing the skin irritation mitigating agent of the present invention exhibits an excellent irritation mitigating effect during actual treatment.

Claims (2)

Red bran (except red bran pigmented rice) skin irritation reducing agent to proteolytic enzyme-treated active ingredient of the extract obtained by extracting with acidic aqueous medium PH1～4. A hair dye containing the skin irritation relieving agent according to claim 1 .