JP4836044B2 - Oral amino acid acne treatment - Google Patents

Description

  The present invention provides an amino acid composition effective for treating acne containing a specific amino acid at a specific ratio as an active ingredient, that is, (a) containing five kinds of amino acids as active ingredients, that is, L-arginine, L -5 types of amino acids of glutamine, L-valine, L-isoleucine and L-leucine are 10 to 40 parts by weight, 10 to 40 parts by weight, 5 to 20 parts by weight, 8 to 30 parts by weight and 10 to 35 parts, respectively. An oral amino acid acne therapeutic agent characterized by containing in parts by mass, a kit of an acne therapeutic agent comprising a combination of such an acne therapeutic agent and an external acne therapeutic agent, and such an acne therapeutic agent and an external acne treatment A method for treating acne in combination with an agent, (b) containing 8 amino acids including the 5 amino acids as active ingredients, ie, L-arginine, L Eight types of amino acids of glutamine, L-valine, L-isoleucine, L-leucine, L-proline, D and / or L-alanine and glycine are 10 to 40 parts by mass, 10 to 40 parts by mass, 20 mass parts, 8-30 mass parts, 10-35 mass parts, 2-10 mass parts, 2-16 mass parts, and the content of 0.5-16 mass parts, The oral amino acid acne therapeutic agent characterized by the above-mentioned , A kit for acne treatment comprising a combination of such an acne treatment agent and an external acne treatment agent, an acne treatment method using such an acne treatment agent and an external acne treatment agent in combination, and (c) the above five types 12 kinds of amino acids including amino acids are contained as active ingredients, that is, L-arginine, L-glutamine, L-valine, L-isoleucine, L-leucine, L-rigid , L-methionine, L-threonine, L-histidine, L-proline, L-phenylalanine and L-tryptophan, 12 kinds of amino acids, 10 to 40 parts by weight, 10 to 40 parts by weight, 5 to 20 parts by weight, respectively 8-30 mass parts, 10-35 mass parts, 2-10 mass parts, 2-20 mass parts, 4-15 mass parts, 2-10 mass parts, 2-10 mass parts, 0.2-10 mass parts And an oral amino acid acne therapeutic agent characterized by containing 0.4 to 4 parts by mass, and a kit for acne therapeutic agent comprising a combination of such an acne therapeutic agent and an external acne therapeutic agent, and such The present invention relates to a method for treating acne using a combination of an acne treatment agent and an external acne treatment agent.

  Acne is a skin disease that more than 90% of adolescent men and women will experience, but because it is an adolescent physiological phenomenon, it has not been treated aggressively. Recently, however, acne after puberty has attracted attention as adult acne.

  Acne is a chronic inflammatory disease that affects sebaceous hair follicles and develops mainly in puberty. Its etiology is intrinsically related to many exogenous factors. There are several stages in the onset mechanism, and it can be roughly divided into two stages. The first stage is surface formation and the second stage is inflammation. Among these, in the process of surface formation, 1) increased sebum secretion mainly due to male hormone action, 2) abnormal keratinization of hair follicle funnel, and 3) degradation of neutral fat in sebum into free fatty acids by bacteria in hair follicles. In the process of promoting inflammation and inducing inflammation, P. acnes-derived extracellular inflammation-inducing substances, particularly neutrophil chemotactic factors are important.

  Treatment varies depending on the stage of acne. Topical sulfur therapy is fundamental for non-inflammatory skin eruptions, and systemic (oral) therapy is not performed in principle. In particular, a sulfur-containing lotion causes exfoliation of the keratin due to its stimulating action and improves mild acne. In addition, as a special treatment, there are systemic oral (oral) therapies of comprehensive metabolic hormones and oral contraceptives. For red papules and pus, which are inflammatory eruptions, local topical therapy and systemic (oral) therapy are mainly used. Non-steroidal anti-inflammatory external preparations and external antibacterial agents are used as topical external medicines, and antibacterial agents and traditional Chinese medicines are used as oral preparations.

However, these methods are taken after consulting a dermatologist. For Japanese people with relatively mild acne compared to Westerners, self-treatment such as purchasing over-the-counter drugs at pharmacies Many cases are seen. In addition, vitamins, fecal adjustment agents, tranquilizers, etc. may be used as auxiliary systemic (oral) therapy. For vitamins, effective amounts of vitamin A 300,000-400,000 international units / day, vitamin B ₆ 30-60 mg / day, and vitamin E 150-300 mg / day are required in large quantities, Regarding A, side effects are also a concern. Commercially available products include vitamin B complex (such as “Chocola BB ace” manufactured by Eisai Co., Ltd. (reference: basic and clinical, 16 (11), 495 (1982)) and “Yokuinogen” manufactured by Kanebo Pharmaceutical Co., Ltd. It has been reported that Chinese medicine and vitamin combination agents such as (reference: basic and clinical, 21 (6), 565 (1987)) have an effect on acne symptoms by internal use. However, no examples using amino acids have been known.

Now, the present inventor has been engaged in research on nutritional and physiological effects of various amino acids for many years, and during that time, it has been found that a specific proportion of a composition of a specific amino acid is effective in improving nutritional status (patents listed below). Document 1), or also found that it has excellent hair growth action, and has already filed a patent for this (Japanese Patent Application No. 2003-199038). However, there was no finding that amino acids had an effect on acne.
JP-A-8-198748

  In view of the background of the prior art described in the preceding paragraph, the present invention aims to provide an excellent acne treatment agent and an acne treatment method using the same.

  As described above, the present inventor has been engaged in research on the nutritional and physiological effects of various amino acids for many years, and it is effective for acne treatment if a specific amino acid is orally ingested at a specific ratio. The present invention was completed based on the finding and such findings.

  That is, as described above, the present invention provides an amino acid composition effective for acne treatment containing a specific amino acid in a specific ratio as an active ingredient, that is, (a) L-arginine, L-glutamine, L- Five amino acids of valine, L-isoleucine and L-leucine are respectively used in proportions of 10 to 40 parts by weight, 10 to 40 parts by weight, 5 to 20 parts by weight, 8 to 30 parts by weight and 10 to 35 parts by weight. (B) containing eight amino acids including the above-mentioned five amino acids as active ingredients, that is, L-arginine, L-glutamine, L-valine, L- 8 kinds of amino acids of isoleucine, L-leucine, L-proline, D and / or L-alanine and glycine are 10 to 40 parts by mass and 10 to 40 parts, respectively. , 5 to 20 parts by weight, 8 to 30 parts by weight, 10 to 35 parts by weight, 2 to 10 parts by weight, 2 to 16 parts by weight, and 0.5 to 8 parts by weight. Amino acid acne therapeutic agent, (c) containing 12 amino acids including the above 5 amino acids as active ingredients, that is, L-arginine, L-glutamine, L-valine, L-isoleucine, L-leucine, L- 12 kinds of amino acids of lysine, L-methionine, L-threonine, L-histidine, L-proline, L-phenylalanine and L-tryptophan are respectively 10 to 40 parts by mass, 10 to 40 parts by mass and 5 to 20 parts by mass. Parts, 8-30 parts by mass, 10-35 parts by mass, 2-10 parts by mass, 2-20 parts by mass, 4-15 parts by mass, 2-10 parts by mass, 2-10 parts by mass, 0.2-10 parts by mass Part and 0 Be contained in an amount of 4-4 parts by weight relates to an oral amino acne treatment agent characterized. The present invention also relates to an acne therapeutic agent kit comprising such an oral acne therapeutic agent and an external acne therapeutic agent, and further relates to an acne treatment method using such an oral acne therapeutic agent and an external acne therapeutic agent in combination.

  Hereinafter, the present invention will be described in detail.

  There are no particular limitations or difficulties in preparing the therapeutic agent for oral amino acid acne of the present invention, and it can be appropriately applied in accordance with conventional methods except that a predetermined amino acid is contained in a predetermined ratio.

  The oral amino acid acne treatment agent of the present invention is prepared by a conventional method using appropriate additives in addition to the above-mentioned predetermined 5, 8, or 12 amino acids simply mixed at the above-mentioned predetermined ratio. You can also Such additives include fruit juice, dextrin, cyclic oligosaccharides, sugars (fructose glucose liquid sugar, sucrose), acidulants, fragrances, powdered green tea powder, emulsifiers that improve texture, collagen, all Fat milk powder, thickening polysaccharides, agar (in the case of jelly drinks), amino acids other than the above-mentioned 5, 8 or 12 amino acids, vitamins, eggshell calcium, calcium pantothenate, other minerals, royal jelly , Propolis, honey, dietary fiber, agaricus, chitin, chitosan, herbal medicine, chondroitin, capsaicin, and the like, which are usually used as components of health foods.

  The therapeutic agent for oral amino acid acne containing 8 amino acids is added to the 5 amino acids contained in the therapeutic agent for oral amino acid acne containing 5 amino acids, in addition to L-proline, D and / or L -Contains 3 types of alanine and glycine. Since these three amino acids are characteristic as constituent amino acids of collagen, they improve the state of the skin dermis and bring about further effects in the treatment of acne.

  The above-mentioned oral amino acid acne treatment agent containing 12 kinds of amino acids contains 5 kinds of amino acids, 5 kinds of amino acids contained in the above-mentioned treatment form of oral amino acid acne, 6 essential amino acids and 1 non-essential amino acid 1 Including species. That is, since it contains all nine essential amino acids and L-arginine, L-glutamine and L-proline, it has high nutritional value, improves skin metabolism, and has further effects on acne treatment.

  There are no particular limitations on the product form of the therapeutic agent for oral amino acid acne of the present invention, and any form may be used as long as it can be taken orally. Examples of such forms include powders, granules, tablets, liquids (such as beverages and jelly beverages), and candy (such as chocolates) using appropriate excipients. As an extreme case of the product form, a simple powder mixture (powder) of the above-mentioned ratio of the above-mentioned 5, 8, or 12 amino acids can be mentioned. In the case of powder, it can be taken directly with water like a powder, or it can be taken by wrapping it in an oblate, or it can be taken by dissolving in water, milk, juice or the like.

  The acne treatment effect according to the present invention focuses on the five amino acids contained in the above-mentioned oral amino acid acne treatment agent, which contains five amino acids as essential components in consideration of the results of Experimental Example 1 described below. Can be achieved by ingesting 4 g or more of the above amino acids in the above ratio in total per day. If the amount is less than this, the desired effect is not achieved. On the other hand, even if it is excessively consumed, the effect is not expected to be improved, so the daily intake can be up to about 12 g of these five amino acids. As an amount included in such a range, for example, about 5 to 7 g / day seen in Experimental Example 1 described below can be cited as a preferable amount. Therefore, the content of the amino acid, which is an essential component in the product of the therapeutic agent for oral amino acid acne of the present invention, may be appropriately determined in consideration of the number of intakes per day. .

  Next, the acne therapeutic agent in the form of a kit of the present invention will be described.

  The acne treatment agent in the form of this kit is a combination of the oral acne treatment agent of the present invention and a commercially available external acne treatment agent as appropriate, which is convenient for the user at the time of purchase.

  Finally, the acne treatment method of the present invention will be described.

  This method is a method of treating acne from the inside or outside of the body by orally ingesting the therapeutic agent for oral acne of the present invention and simultaneously applying the therapeutic agent for external use. It is a method that is more effective in treating acne than when it is based on.

  Hereinafter, the present invention will be described in more detail with reference to test examples.

Test Example 1 (Amino Acid Administration Test for Acne Patients)
(1) Outline of the test:
(A) In acne patients, the usefulness of acetic acid against acne symptoms was examined.

  (B) The subjects were 38 people aged 20 to 45 years, the average age was 28.6 years, and the number of acne self-reported was 10 inflammatory and non-inflammatory rashes on the cheeks and jaws. For those who were recognized above.

  (C) The test was performed after 3 meals a day, after “Amino Vital” (Ajinomoto Co., Inc. amino acid preparation, L-arginine, L-glutamine, L-valine, L-isoleucine and L-leucine) or a placebo product thereof. Was taken for 8 weeks (daily dose: 6.6 g of the above 5 amino acids), visited before, 4 and 8 weeks after the start of the study, and photographed the whole face and left and right cheeks. .

  (D) Acne status was ranked in 6 levels from 0 to 5 according to photos taken by dermatologists. In the amino acid intake group (Group A), 7 photos improved after 4 weeks from the start of intake. There were 8 cases that remained unchanged and 4 cases that worsened. In addition, in the photograph 8 weeks after the start of amino acid intake, 10 cases improved, 8 cases remained unchanged, and 1 case worsened. See Table 3 below. In contrast, in the placebo ingestion group (Group B), 4 weeks after the start of ingestion, 1 case improved, 13 cases remained unchanged, and 5 cases worsened. Four weeks later, there were 4 cases that improved, 11 cases that remained unchanged, and 4 cases that deteriorated. See Table 2 below.

  (E) From the above results, the effect of the therapeutic agent for oral amino acid acne of the present invention was significantly recognized.

(2) Test details:
(A) Subject:
The 38 subjects were divided into two groups, group A consisting of 19 people and group B consisting of 19 people, so that acne symptoms were equalized. Group A is a group that takes amino acids, and Group B is a comparative control group that takes placebo products that do not contain amino acids.

In addition, the test content was fully explained to the subjects, and the test was conducted after obtaining the consent of the person. In addition, when the subject of the selection of the 38 people is, it can not comply with the provisions of this test women who have merged the disease which is considered the evaluation affect of, pregnant women and lactating women, and this study implementation plan Women were excluded. Moreover, as a restriction | limiting matter, it can mention mentioning that the amino acid supplement which is considered to affect a test result is used regularly.

(B) Test schedule:
The intake period of the test product was 8 weeks, and the subjects were to perform the test according to the schedule shown in Table 1 below.

(C) How to take the test product:
The product under test is the amino acid preparation “Amino Vital” (daily amount: 6.6 g of the above 5 types of amino acids) or a placebo product that does not contain amino acids and contains all other ingredients after each meal 3 times a day. Ingested.

  Here, the amino acid preparation “Amino Vital” ingested by Group A contains a total of 2.2 g of the above five amino acids in 4.5 g of one bag, and the weight ratio of these amino acids is L-arginine 23: L- Glutamine 25: L-valine 14: L-isoleucine 17: L-leucine 21.

(D) Photography and subject diary:
(I) Photographing: Photographs of the entire face and left and right cheeks were taken on each visit day, and the acne condition was determined by the dermatologist in the following 6 levels of 0-6.

    (Ii) Subject diary: scored for acne and general skin condition and observed changes in symptoms.

(E) Test results:
(I) Photography: Judgment results of dermatologists are summarized in Tables 2 and 3 below.

    (Ii) Subject evaluation: Subject questionnaire results after 4 weeks and 8 weeks of intake are summarized in Table 4 below. In the amino acid intake group, the placebo group was evaluated to show that acne prominence, acne count, acne redness, and acne scars tended to improve compared to the beginning of the study. In addition, there was a tendency that each symptom was improved 8 weeks later than 4 weeks after the start of the test.

ADVANTAGE OF THE INVENTION According to this invention, the acne therapeutic agent which has no side effect and can improve a physical condition can be provided easily.

Claims (4)

  5 amino acids of L-arginine, L-glutamine, L-valine, L-isoleucine and L-leucine are respectively 10 to 40 parts by mass, 10 to 40 parts by mass, 5 to 20 parts by mass, and 8 to 30 parts by mass. Oral amino acid acne therapeutic agent (except food), characterized by containing 10 parts by weight and 10 to 35 parts by weight.   Eight amino acids of L-arginine, L-glutamine, L-valine, L-isoleucine, L-leucine, L-proline, D and / or L-alanine and glycine, 40 mass parts, 5-20 mass parts, 8-30 mass parts, 10-35 mass parts, 2-10 mass parts, 2-16 mass parts, and 0.5-8 mass parts are contained, It is characterized by the above-mentioned. Oral amino acid acne treatment (except food).   12 types of L-arginine, L-glutamine, L-valine, L-isoleucine, L-leucine, L-lysine, L-methionine, L-threonine, L-histidine, L-proline, L-phenylalanine and L-tryptophan 10-40 parts by mass, 10-40 parts by mass, 5-20 parts by mass, 8-30 parts by mass, 10-35 parts by mass, 2-10 parts by mass, 2-20 parts by mass, respectively. 15 mass parts, 2-10 mass parts, 2-10 mass parts, 0.2-10 mass parts, and the content of 0.2-10 mass parts and the oral amino acid acne therapeutic agent (however, foodstuffs) characterized by the above-mentioned except for). An acne treatment kit comprising a combination of the oral amino acid acne treatment agent according to any one of claims 1 to 3 and an external acne treatment agent.