JP4844899B2 - Air conditioning system for bioprocessing facility - Google Patents

Description

  The present invention relates to an air conditioning system for a facility having a biopreparation work room such as a cell culture / preparation room, a biohazard countermeasure room, a genetic operation room in a regenerative medical facility, and is caused by occurrence of an emergency such as a natural disaster or an accident. The present invention relates to an air conditioning system for a bioprocessing facility that can control the amount of supply and exhaust air so as to produce a pressure difference between the working chamber and the surrounding environment in order to prevent the working chamber from deviating from the pressure range that should be maintained.

  The cell culture / preparation room in the regenerative medical facility is controlled to be positive pressure to prevent inflow of unclean air from the outside, while in biopreparation work rooms such as biohazard countermeasure rooms and genetic operation rooms, The working chamber is controlled so as to have a negative pressure with respect to the surroundings, thereby preventing substances such as biological materials and pathogens from flowing out from the working chamber to the surroundings. As a method for controlling and maintaining the indoor pressure accompanying the opening and closing of the door, which is a disturbance to the positive pressure or negative pressure environment, there is a method of adjusting the indoor air supply amount and exhaust amount with a damper or the like (Patent Documents 1 and 2).

FIG. 10 shows an example of a facility having a bio-preparation work room used for cell culture / preparation, biohazard countermeasures, and gene manipulation. In general, there are a plurality of work rooms 1 (1a, 1b,...) According to the work contents. There is a work room 1, a dressing room 2, and a dressing room 3 as a set unit for each work unit. After wearing sterile clothes in the clothing room 2 which is the front room of the work room 1, the work room is entered and the work is executed. After the work is finished, the user enters the undressing room 3 which is the rear room, and removes the sterile clothes and goes outside. There is a management corridor 4 common to each work unit, and it is possible to enter and leave the building outside through the front room 5 at the entrance of the building. In the case of a biohazard countermeasure room, the pressure in the work room 1, the dressing room 2, the undressing room 3, and the management corridor 4 is set such that the pressure in the management corridor 4 is ± 0, the dressing room 2 is positive, and the work room 1 is negative. The undressing chamber 3 is set to a negative pressure further than the working chamber 1. Work through the management corridor 4 while entering and leaving the dressing room 2 and the dressing room 3 to maintain a negative pressure in the work room 1 and prevent biological materials and pathogens from flowing out around the management corridor 4 and equipment. Intrusion of dust into the chamber 1 is prevented, and the cleanliness in the work chamber 1 can be maintained. As shown in FIG. 11, the work room 1, the dressing room 2, the dressing room 3, the management corridor 4, and the front room 5 have independent air supply systems and exhaust systems, respectively. The set pressure is maintained by adjusting with dampers 7 and 8. Normally, when the biopreparation work room is a biohazard countermeasure room, negative pressure is maintained as described above (see FIG. 12), and in the case of a cell preparation work room for regenerative medicine, positive pressure is maintained. Done. For this reason, an air supply fan 6 is placed at the entrance of each unit, and this is branched to supply air to the work chamber 1. The adjustment of the air supply amount and the exhaust amount is performed by adjusting the opening degree of the damper 7 provided in the air supply system of each chamber and the damper 8 provided in the exhaust system and controlling the rotational speed of the fan.
JP-A 63-247542 JP 2006-223207 A

  However, in the conventional air conditioning system of a bioprocessing facility, when the supply / exhaust system of the biopreparation work room is damaged or the work room wall is damaged by a disaster or accident such as an earthquake, as shown in FIG. In addition, cells that are unable to maintain the working room at the specified negative pressure (or positive pressure), and that harmful substances such as biological materials and pathogens flow out into other working rooms and the surrounding area, or are contaminated or controlled. On the other hand, there is a possibility that cells may not be used due to contamination.

  The present invention pays attention to the above-mentioned conventional problems, and a bio-preparation work room that needs to maintain positive pressure or negative pressure, such as a cell culture / preparation room, a biohazard countermeasure room, and a genetic operation room in a regenerative medical facility, such as an earthquake Even if it becomes difficult to control the pressure inside the room due to damage caused by a disaster or equipment failure, maintain positive or negative pressure to minimize the maintenance of cleanliness in the work room and the spread of contamination. The objective is to provide an air conditioning system that can ensure environmental safety.

  To achieve the above purpose, if the air supply / exhaust system of the work room is damaged or the work room wall is damaged, the pressure control settings for the damaged work room's dressing room and undressing room should be set. Basically, the pressure in the dressing room and the dressing room is changed to be higher or lower than usual and the working room pressure is maintained at a positive pressure or a negative pressure.

  That is, the present invention is a bioprocessing facility air conditioning system comprising a biopreparation work room, a doorway to the work room, and an independent control means for each indoor pressure, the biopreparation work room, When the pressure in the bio-preparation work chamber exceeds a specified value, the conduction valve is opened and the pressure control in the entry / exit chamber is changed to allow conditioned air to communicate with the entrance / exit chamber via a conduction valve. It is characterized by comprising control means for maintaining the pressure in the biopreparation work chamber within a specified value by performing the supply / discharge control.

Further, the present invention is an air conditioning system for a bioprocessing facility comprising a plurality of units each having a biopreparation working chamber, a doorway to the working chamber, and an independent control means for each indoor pressure, The bio-preparation work chamber of each unit and the entrance / exit chamber can be communicated with each other via a conduction valve, and the units can be communicated with each other by a bypass path having a damper therebetween. When the specified value is exceeded, the conduction valve in the unit is opened to change the pressure control of the entrance / exit chamber to control the supply / exhaust of the conditioned air, and by the adjacent unit through the damper interposed between the units. It is good also as a structure provided with the control means which enables additional supply / discharge control and maintains the said bio-preparation working chamber pressure within a regulation value.
In this case, the bypass path between the units may be set on the exhaust side of the unit or on the supply side of the unit. Of course, it is also possible to configure at the same time.

  More specifically, a bio-preparation work room, a dressing room and a dressing room for entering and exiting the work room, a management hallway connected to the dressing room and the dressing room, and a front room for entering and exiting the management hallway An air conditioning system of a bioprocessing facility comprising a plurality of units each having a chamber and a work room, a dressing room, a dressing room, a management corridor, and an air conditioning system that independently maintains and controls the pressure in the front chamber, An emergency continuity valve capable of communicating between the work room, the dressing room, and the dressing room is provided, and means for detecting whether or not the set pressure cannot be maintained by detecting the pressure in the work room is provided and cannot be maintained. Based on the determination result, the emergency continuity valve between the adjacent dressing room and undressing room is opened, and the pressure in each chamber is controlled to a negative pressure or a positive pressure that is larger than normal, thereby maintaining the working chamber pressure at the set pressure. Let

  In this case, it may be configured to have a control unit that senses an abnormality in the pressure in the work room and automatically switches the operation of the air conditioning equipment in the clothing room and the dressing room. In addition, if the pressure in the work room where the failure occurred cannot be maintained just by using the supply / exhaust system of the dressing room and the dressing room, the management corridor, the front room, other work rooms around, the dressing room, the dressing room The pressure in the working chamber in which a failure has occurred may be maintained at a set value by using the air supply / exhaust system.

  With the above configuration, inflow of outside air to the cell culture / preparation room in the event of a disaster or accident, or harmful substances such as biomaterials and pathogens flow out of the biopreparation work room such as the biohazard countermeasure room or the genetic operation room. As a result, it becomes possible to suppress the spread of contamination and provide safer equipment.

Hereinafter, specific embodiments of an air conditioning system for a bioprocessing facility according to the present invention will be described in detail with reference to the drawings.
FIG. 1 shows an air conditioning system for a bioprocessing facility according to the embodiment, and FIG. 2 shows a configuration of the facility. This example is intended to be applied to a regenerative medical facility as a bioprocessing facility. A cell preparation work room 11 in which a safety cabinet or the like is accommodated, a dressing room 12 as a front room, and a dressing room 13 as a back room. , And a plurality of units (3 units in the embodiment) are provided side by side according to the content of work (separately indicated by additional symbols a, b, and c. The same applies hereinafter). A management corridor 14 serving as an entrance / exit for the dressing room 12 and the undressing room 13 of each unit is provided, and it has been conventionally possible to enter / exit from the management corridor 14 through the front room 15 with the outdoor part of the building. (See FIG. 13).

Each unit has an independent air supply system and exhaust system, and conditioned air sent out by the air supply fan 16 is supplied to each room, and an air supply amount adjusting damper 17 (17 _1a , 17 _2a , 17 _3a ) and the outlet displacement adjusting damper 18 (18 _1a , 18 _2a , 18 _3a ) adjust the outlet flow rate. Each indoor pressure is adjusted independently by opening control of both the dampers 17 and 18. A filter 50 is disposed at the entrance / exit of the conditioned air to / from each room to purify the conditioned air entering / exiting the room.

In addition, air-conditioning air can be simultaneously sent to the management corridor 14 and the front room 15 of the building by the air supply fan 16d. The air supply air can be branched and supplied through the air supply amount adjusting dampers 17 ₁₄ and 17 _15. Air is supplied and the exhaust amount is adjusted by the exhaust amount adjusting dampers 18 ₁₄ and 18 ₁₅ at the outlet. An exhaust fan 19d is provided at these joining portions.

In the present embodiment, in particular, the bio-preparation work chamber 11a is a dressing room 12a as loading and unloading chamber which are adjacent to each other, communicating passages is interposed conductive valve 20 _12, 20 ₁₃ with respect to the changing room 13a In this case, the internal pressure of the bio-preparation working chamber 11 is controlled to be maintained at a specified value in an emergency. For this reason, when the internal pressure of the biopreparation working chamber 11 exceeds a specified value, the conduction valve 20 is opened, and the pressure control of the clothing chamber 12a and the dressing chamber 13a, which are the entrance / exit chambers, is changed to control the conditioned air. Control means (not shown) for maintaining the pressure in the bio-preparation working chamber 11 within a specified value by performing supply / discharge control is provided.

FIG. 3 is a control flowchart by the control means, and FIG. 6 is a time chart showing how the pressure changes according to the operation of the control means. That is, in regenerative medicine (maintaining positive pressure), as shown in FIG. 2, in the normal state, the dressing chamber 12 has a pressure of (+15 Pa) (symbol ++), and the work chamber 11 has a pressure close to atmospheric pressure (+5 Pa). Pressure (symbol +), the dressing room 13 is controlled to maintain a pressure (symbol-) of (-15 Pa) (step 100). Control within the normal setting range of such fans 16 and 19 and dampers 17 and 18 is performed. In this control process, when the work chamber 11a is damaged due to an earthquake or an accident, the pressure in the chamber fluctuates, and when an abnormal signal in which the pressure in the work chamber 11a approaches 0 (atmospheric pressure) is detected (step 110), It is detected whether an abnormal signal is output from the fans 16 and 19 and the dampers 17 and 18 (step 120). If this abnormal signal is detected, each device is inspected (step 121). If there is no abnormality, it is confirmed whether or not the internal pressure abnormality in the working chamber 11a continues for a certain period of time (for example, 1 minute) (step 130). And take appropriate measures such as displaying this (step 131). It is detected whether or not the pressure abnormality continues for more than 1 minute of the specified time and is below the threshold (+2 Pa) (step 140). If the threshold is not exceeded, an initial warning is displayed (step 141). If so, start emergency work. This is to perform a normal value return operation of the pressure in the working chamber 11a, and it is only necessary to increase the amount of air supplied to the working chamber 11a beyond the normal air supply range and decrease the amount of exhaust (step). 150). The opening / closing control of the dampers 17 _1a and 18 _1a may be performed individually. If it returns by this, a warning display will be complete | finished (step 161). If return, in order to converge within specified pressure, and the conduction valve 20 _12a between dressing room 12a and the working chamber 11a is opened, maintaining a positive pressure in the working chamber 11a by increasing the supply air amount to the dressing room 12a (Step 170).

Thereafter, it is evaluated whether or not the pressure in the working chamber 11a has returned to normal (step 180), and if it has returned, a secondary warning is displayed (step 181). If this does not return to the conduction valve 20 _13a between undressing chamber 13a and the working chamber 11a is opened, closing the exhaust amount adjusting damper 18 _3a, is performed hazard warning display simultaneously (step 190). By such a series of processes, the pressure in the working chamber 11a is maintained at a positive pressure, and the outside air is effectively prevented from entering the inside.

FIG. 5 shows a control flowchart when the biopreparation working room 11 is used as a biohazard countermeasure room, and FIG. 6 shows a time chart. In this case, control is performed to maintain the working chamber 11a at a negative pressure. As shown in FIG. 5, steps 200 to 230 are the same as steps 100 to 130 of the positive pressure maintenance control of FIG. In step 240, a comparison with a threshold value (−5 Pa) is performed, and when the pressure rises above a specified pressure (−15 Pa, symbol − in FIG. 2), the opening degree of the work chamber exhaust damper 18 _1a is increased. (Step 250). Discontinue a warning display if the return pressure (step 261), then the conduction valve 20 _13a between undressing chamber 13a and the working chamber 11a otherwise opened, to increase the opening degree of the exhaust gas amount adjusting damper 18 _3a (step 270). Then, it is checked whether or not the pressure has been restored (step 280). If the pressure has been restored, a secondary warning is displayed (step 281). If the pressure has not been restored, this time between the clothing room 12a and the work room 11a. the conducting valve 20 _12a to open, increasing the opening degree of the exhaust gas amount adjusting damper 18 _2a of dressing room 12a, to maintain a negative pressure in the working chamber 11a (step 270). Next, it is checked whether or not the working chamber pressure has been restored (step 300). If the working chamber pressure has been restored, a tertiary warning is issued (step 301). Otherwise, the air supply damper 17 _1a of the working chamber 11a is closed, and the final A warning is issued (step 301).

  Next, FIG. 7 shows a configuration diagram of an air conditioning system of a bioprocessing facility according to the second embodiment. The air conditioning system according to the second embodiment is a modification of the case where the work chamber 11 is maintained at a positive pressure. When the air supply system cannot catch up with the supply air amount of one system, it is combined with the air supply system of an adjacent unit. It is intended to maintain the pressure.

In other words, the present invention is intended for an air conditioning system of a bioprocessing facility provided with a plurality of units each having a biopreparation working room, an entrance / exit room to the working room, and an independent control means for each room pressure. As shown in FIG. 7, air supply fans 16a, 16b, 16c, and 16d are provided corresponding to each unit. In this embodiment, the air supply lines from these air supply fans 16 to each unit are short-circuited. Bypass passages 22 _ab , 22 _bc , 22 _cd are provided, and dampers 23 _ab , 23 _bc , 23 _cd that can open and close the flow passages are provided. Other configurations are the same as those in FIG. Thus, when at least one of the biopreparation work chamber pressures exceeds a specified value, the control valve (not shown) opens the conduction valve 20 in the unit and the clothes chamber 12 and the dressing chamber 13 which are the entrance / exit chambers. The pressure control of the air conditioning air is changed to control the supply / discharge of the conditioned air, and the additional supply / discharge control by the adjacent unit is enabled through the damper 23 (23 _ab , 23 _bc , 23 _cd ) interposed between the units. The pressure in the preparation work chamber 11 can be maintained at a positive pressure within a specified value.

  FIG. 8 shows a configuration diagram of an air conditioning system of a bioprocessing facility according to the third embodiment. The air conditioning system according to the third embodiment is a modified example in which the work chamber 11 is maintained at a negative pressure. When the exhaust amount of one system cannot keep up, the damaged system is combined with the exhaust system of an adjacent unit. This is intended to maintain the negative pressure in the chamber 11.

The air conditioning system according to the third embodiment is different only in that the bypass path of the second embodiment and the damper interposed therein are provided in the exhaust pipe line from each unit to the exhaust fan 1. That is, bypass passages 32 _ab , 32 _bc , 32 _cd that short-circuit the exhaust pipes from each unit to the exhaust fan 19 are provided, and dampers 33 _ab , 33 _bc , 33 _cd that can open and close the flow passages are provided in these. It is a thing. Also in this embodiment, when at least one of the biopreparation working chamber pressures exceeds a predetermined negative pressure, the control valve (not shown) opens the conduction valve 20 in the unit and is the entrance / exit chamber. The pressure control of the dressing room 12 and the dressing room 13 is changed to control the supply and discharge of the conditioned air, and the damper 33 (provided in the bypass paths 32 _ab , 32 _bc , 32 _cd of the exhaust path interposed between the units) 33 _ab , 33 _bc , 33 _cd ) enables additional supply / discharge control by an adjacent unit, and the pressure in the biopreparation working chamber 11 can be maintained at a negative pressure within a specified value.

  Further, FIG. 9 shows an air conditioning system according to the third embodiment. In this arrangement, an air supply fan 47 and an exhaust fan 48 are arranged in place of the supply / discharge dampers 17 and 18 provided at the entrances and exits of the work room 11, the dressing room 12, and the dressing room 13 to enhance the supply / discharge capacity. . In this embodiment, pressure control can be performed not by adjusting the damper opening but by fan power control, so that supply / discharge control can be performed with a large supply / discharge capability.

  As described above, in the present embodiment, the internal pressure of the biopreparation working chamber is controlled to a prescribed positive pressure in the case of a cell preparation working chamber for regenerative medicine, and to a negative pressure in the case of a biohazard countermeasure room. It is necessary, but if a pressure abnormality in the work room is detected in the event of a disaster or accident, change the pressure control settings for the dressing room and undressing room, and adjust the air supply and exhaust rates to change the dressing room and undressing room. The pressure in the room is higher than usual (in the case of cell preparation work for regenerative medicine) or lower (in the case of a biohazard countermeasure room), and the air in the work room is supplied or exhausted through the adjacent dressing room and dressing room. Maintain the working chamber pressure at positive or negative pressure. This makes it possible to prevent contamination due to the inflow of outside air into the cell preparation work room, or to suppress the spread of contamination due to biological materials and pathogens to only one set of work room, dressing room, and dressing room. Contamination to other work rooms can be prevented.

  In the case of maintaining the negative pressure, the air in the normal working room can be exhausted from the dressing room and the dressing room through the gap between the doors for entering and leaving the room. However, when the required displacement is large or the door is very airtight, it is expected that a sufficient displacement cannot be obtained and it is difficult to maintain the negative pressure. For this reason, although it is normally closed between the dressing room, the dressing room, and the work room, it is preferable to provide a conduction valve that opens when a pressure abnormality in the work room is detected. By opening the conduction valve, airflow easily flows from the work room to the dressing room and the dressing room, and the work room can be maintained at a negative pressure.

  If the pressure in the work room cannot be maintained even by the above-described method, the pressure in the broken work room is maintained by lowering the pressure in the management corridor or another adjacent dressing room, undressing room, or work room. By reducing the pressure in the adjacent chambers in this way, it is possible to suppress as much as possible the spread of contamination by biological materials and pathogens.

1 is a configuration diagram of an air conditioning system of a bioprocessing facility according to a first embodiment of the present invention. It is a plane lineblock diagram of a biotreatment facility where an air-conditioning system concerning an embodiment is applied, and explanatory drawing of pressure regulation. It is a positive pressure control flowchart of the air-conditioning system of the bioprocessing facility which concerns on 1st Embodiment of this invention. FIG. 4 is a time chart of the control of FIG. 3. It is a negative pressure control flowchart of the air-conditioning system of the bioprocessing facility which concerns on 1st Embodiment of this invention. 6 is a time chart of the control of FIG. It is a block diagram of the air-conditioning system of the bioprocessing facility which concerns on 2nd Embodiment of this invention. It is a block diagram of the air-conditioning system of the bioprocessing facility which concerns on 3rd Embodiment of this invention. It is a block diagram of the air-conditioning system of the bioprocessing facility which concerns on 4th Embodiment of this invention. It is a layout diagram of a conventional bioprocessing facility and a flow diagram of people. It is an air-conditioning system block diagram of the conventional bioprocessing facility. It is explanatory drawing of the indoor pressure of the conventional bioprocessing plant | facility, and the flow of airflow. It is explanatory drawing which shows the pollution expansion state at the time of the disaster of the conventional bioprocessing facility.

Explanation of symbols

11 ... …… Bio-preparation work room, 12 ......... Clothing room, 13 ......... Undressing room, 14 ......... Management corridor, 15 ......... Front room, 16 ......... Air supply fan, 17, 18 ... ... Damper, 20 ... Conductor valve.

Claims (3)

An air conditioning system for a bio-processing facility comprising a plurality of units each having a bio-preparation working room, an entrance / exit to the working room, and an independent control means for each room pressure,
The bio-preparation working chamber of each unit and the entrance / exit chamber can be communicated with each other via a conduction valve, and an air supply fan and an exhaust fan are provided corresponding to each unit, and each unit is provided by a bypass path with a damper interposed therebetween. The position at the downstream side of the air supply fan and the air supply side of the unit, or the position at the upstream side of the exhaust fan and the exhaust side of the unit can communicate with each other. When the indoor pressure exceeds a specified value, the continuity valve in the unit is opened to change the pressure control of the entrance / exit chamber to control supply / exhaust of conditioned air, and through the damper interposed between the units. It is characterized by comprising control means for enabling additional supply / discharge control by an adjacent unit and maintaining the pressure in the biopreparation work chamber within a specified value. Air conditioning system of Io processing facility. The air-conditioning system for a bioprocessing facility according to claim 1 , wherein the bypass path between the units is set on the exhaust side of the unit. The air conditioning system for a bioprocessing facility according to claim 1 , wherein the bypass path between the units is set on the air supply side of the unit.

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