JP4857599B2 - Cosmetic composition and method for producing the same - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To obtain a cosmetic composition which can be easily used for both emulsion- and non-emulsion cosmetics and is excellent in antiseptic and antibacterial properties, to provide a production method therefor and a method for reducing the amounts of antiseptic and antibacterial agents by improving antiseptic and antibacterial effects of the cosmetic composition having a polyorganosiloxane-containing &epsi;-polylysine. <P>SOLUTION: The cosmetic composition contains at least one selected from the polyorganosiloxane-containing &epsi;-polylysine compound and a physiologically acceptable salt thereof and a polyhydric alcohol, wherein the polyorganosiloxane-containing &epsi;-polylysine compound is obtained by reacting &epsi;-polylysine with a polyorganosiloxane. <P>COPYRIGHT: (C)2006,JPO&amp;NCIPI

Description

  The present invention relates to a cosmetic composition containing a polyorganosiloxane-containing ε-polylysine compound or a physiologically acceptable salt thereof and a polyhydric alcohol, and a method for producing the same.

  In recent years, the number of users who have sensitive skin that reacts sensitively to chemical substances contained in cosmetics has been increasing. Accordingly, there is a need in the cosmetics industry for antiseptic antibacterial agents that have a sufficient antiseptic antibacterial effect and are highly safe. Moreover, reduction of the compounding density | concentration of antiseptic antibacterial agent is calculated | required.

  Ε-Polylysine, a kind of antibacterial agent formulated for the purpose of preserving or sterilizing the cosmetic product itself, is highly safe against the skin and stable over time even when formulated in cosmetics. It has been reported that it has antiseptic and bactericidal effects and is very useful as an antiseptic disinfectant used in cosmetics [for example, Japanese Patent Publication No. 05-64608 (Patent Document 1)]. In addition, since ε-polylysine is an amino acid homopolymer and has extremely low volatility, the antiseptic and bactericidal effects associated with the evaporation of ε-polylysine are unlikely to occur.

  In addition, since ε-polylysine is water-soluble, it is highly soluble in water and some alcoholic solvents that are commonly used in cosmetics, but is widely used in emulsified cosmetics, especially emulsified cosmetics. Low affinity with silicone such as polyorganosiloxane, which is a base. Therefore, it is very difficult to uniformly mix ε-polylysine and polyorganosiloxane, and it is necessary to add a surfactant or the like.

Japanese Patent Publication No.05-64608 Japanese Patent No. 1245361

  Under the circumstances as described above, development of a cosmetic composition that can be easily used for both emulsified and non-emulsified cosmetics and has excellent antiseptic and antibacterial properties is desired. In addition, development of a method for improving the antiseptic or antibacterial effect of a cosmetic composition having polyorganosiloxane-containing ε-polylysine and reducing the amount of the antiseptic antibacterial agent used is also desired.

［式（１）中、Ｖは下記式（５）

で表される繰り返し単位１と、下記式（６）

で表される繰り返し単位２が不規則に重合したランダム共重合体、繰り返し単位１と繰り返し単位２が交互に重合した交互共重合体、または、繰り返し単位１のみからなるブロックと繰り返し単位２のみからなるブロックが結合したブロック共重合体であり、繰り返し単位１の繰り返し数aは０〜５０の整数、繰り返し単位２の繰り返し数bは０〜５０の整数及びa＋bは１〜５０の整数であり、Ａ¹は下記式（２）
−Ｘ−Ｙ−Ｚ （２）
｛式（２）中、Ｘは

（式中、Ｒ¹は炭素数１〜５の直鎖もしくは分岐鎖のアルキレン基、炭素数２〜５のアルケニレン基又は炭素数６〜１０のアリーレン基を表す）であり、Ｙは、炭素数１〜１０００の直鎖もしくは分岐鎖のアルキレン基であり、このアルキレン基中の相隣接しない任意のメチレン基は−Ｏ−(エーテル)で置換されていてもよく、Ｚは下記式（３）又は下記式（４）

（式（３）及び式（４）中のＲ²及びＲ³は、互いに独立した炭素数１〜２０の直鎖もしくは分岐鎖のアルキル基又は炭素数６〜１０のアリール基であり、cは１〜１０００の整数、dは１〜１０００の整数、eは０〜１０００の整数である。）で表されるポリオルガノシロキサン基である。｝で表される基であり、Ａ²及びＡ³は互いに独立してアミノ基又は上記式（２）で表される基であり、ａが０の場合にＡ²とＡ³が共にアミノ基であることはない。］
で表されるポリオルガノシロキサン含有ε−ポリリジン化合物又はその生理学的に許容されうる塩の１種又は２種以上と、多価アルコールとを含有する化粧料組成物である。
ここで、前記繰り返し単位１の繰り返し数aは０〜２０の整数、繰り返し単位２の繰り返し数bは２０〜４０の整数及びa＋bは１０〜４０であることが好ましい。また、a＋bは、３０〜４０であることがさらに好ましい。

式（２）中のＸは、特に

が好ましい。
また、式（２）中のＺ中のＲ²とＲ³は、それぞれ互いに独立して、炭素数１〜１０のアルキル基、または炭素数６〜１０のアリール基が好ましく、炭素数１〜５のアルキル基、またはフェニル基がさらに好ましい。これらの中でも、メチル基、n-ブチル基がもっとも好ましい。 The first aspect of the present invention is a cosmetic composition containing one or more polyorganosiloxane-containing ε-polylysine compounds or physiologically acceptable salts thereof and a polyhydric alcohol.
The first aspect of the present invention is the following formula (1).

[In the formula (1), V represents the following formula (5)

A repeating unit 1 represented by the following formula (6):

A random copolymer in which the repeating units 2 are irregularly polymerized, an alternating copolymer in which the repeating units 1 and 2 are alternately polymerized, or a block consisting of only the repeating unit 1 and only the repeating unit 2 A block copolymer in which the blocks are combined, the repeating number 1 of the repeating unit 1 is an integer of 0 to 50, the repeating number b of the repeating unit 2 is an integer of 0 to 50, and a + b is an integer of 1 to 50, A ¹ is the following formula (2)
-X-Y-Z (2)
{In Formula (2), X is

(Wherein R ¹ represents a linear or branched alkylene group having 1 to 5 carbon atoms, an alkenylene group having 2 to 5 carbon atoms, or an arylene group having 6 to 10 carbon atoms), and Y represents the number of carbon atoms 1 to 1000 linear or branched alkylene groups, and any non-adjacent methylene group in the alkylene group may be substituted with -O- (ether), and Z is the following formula (3) or Following formula (4)

(R ² and R ^{3 in} Formula (3) and Formula (4) are each independently a linear or branched alkyl group having 1 to 20 carbon atoms or an aryl group having 6 to 10 carbon atoms, and c is An integer of 1-1000, d is an integer of 1-1000, and e is an integer of 0-1000. }, A ² and A ³ are each independently an amino group or a group represented by the above formula (2), and when a is 0, both A ² and A ³ are amino groups Never. ]
A polyorganosiloxane-containing ε-polylysine compound or a physiologically acceptable salt thereof, and a cosmetic composition containing a polyhydric alcohol.
Here, the repeating number a of the repeating unit 1 is preferably an integer of 0 to 20, the repeating number b of the repeating unit 2 is preferably an integer of 20 to 40, and a + b is preferably 10 to 40. Further, a + b is more preferably 30-40.

X in formula (2) is in particular

Is preferred.
Further, R ² and R ^{3 in} Z in the formula (2) are preferably each independently an alkyl group having 1 to 10 carbon atoms or an aryl group having 6 to 10 carbon atoms, and 1 to 5 carbon atoms. Of these, an alkyl group or a phenyl group is more preferable. Among these, a methyl group and an n-butyl group are most preferable.

で表される繰り返し単位２の繰り返し数ｂが５以上であるポリオルガノシロキサン含有ε−ポリリジン化合物又はその生理学的に許容されうる塩の１種又は２種以上を含有することが好ましい。
本発明の第１の態様の化粧料組成物において、ポリオルガノシロキサン含有ε−ポリリジン化合物を構成する下記式（５）

で表される繰り返し単位１の繰り返し数ａと、下記式（６）

で表される繰り返し単位２の繰り返し数ｂが、０．１≦ｂ／（ａ＋ｂ）≦０．９８を満たすことが好ましい。 In the cosmetic composition of the first aspect of the present invention, the following formula (6) constituting the polyorganosiloxane-containing ε-polylysine compound:

It is preferable to contain 1 type, or 2 or more types of the polyorganosiloxane containing epsilon-polylysine compound or its physiologically acceptable salt whose repeating unit 2 represented by these is b or more.
In the cosmetic composition of the first aspect of the present invention, the following formula (5) constituting the polyorganosiloxane-containing ε-polylysine compound:

The repeating number a of the repeating unit 1 represented by the following formula (6)

It is preferable that the repeating number b of the repeating unit 2 represented by the above satisfies 0.1 ≦ b / (a + b) ≦ 0.98.

で表される基であることが好ましい。
本発明の第１の態様の化粧料組成物において、ポリオルガノシロキサン含有ε−ポリリジン化合物を構成する下記式（２）
−Ｘ−Ｙ−Ｚ （２）
で表される基のＸが、

（式（２）のＸ中、Ｒ¹は炭素数１〜５の直鎖もしくは分岐鎖のアルキレン基、炭素数２〜５のアルケニレン基又は炭素数６〜１０のアリーレン基を表す。）
で表される基であることが好ましい。
本発明の第１の態様の化粧料組成物において、ポリオルガノシロキサン含有ε−ポリリジン化合物を構成する下記式（２）
−Ｘ−Ｙ−Ｚ （２）
で表される基のＸが、

（式（２）のＸ中、Ｒ¹は炭素数１〜５の直鎖もしくは分岐鎖のアルキレン基、炭素数２〜５のアルケニレン基又は炭素数６〜１０のアリーレン基を表す。）
で表される基であることが好ましい。
本発明の第１の態様の化粧料組成物において、ポリオルガノシロキサン含有ε−ポリリジン化合物を構成する下記式（２）
−Ｘ−Ｙ−Ｚ （２）
で表される基のＸが、

で表される基であることが好ましい。
本発明の第１の態様の化粧料組成物において、ポリオルガノシロキサン含有ε−ポリリジン化合物を構成する下記式（２）
−Ｘ−Ｙ−Ｚ （２）
で表される基のＸが、

で表される基であることが好ましい。 In the cosmetic composition according to the first aspect of the present invention, the following formula (2) constituting the polyorganosiloxane-containing ε-polylysine compound:
-X-Y-Z (2)
X of the group represented by

It is preferable that it is group represented by these.
In the cosmetic composition according to the first aspect of the present invention, the following formula (2) constituting the polyorganosiloxane-containing ε-polylysine compound:
-X-Y-Z (2)
X of the group represented by

(In X in Formula (2), R ¹ represents a linear or branched alkylene group having 1 to 5 carbon atoms, an alkenylene group having 2 to 5 carbon atoms, or an arylene group having 6 to 10 carbon atoms.)
It is preferable that it is group represented by these.
In the cosmetic composition according to the first aspect of the present invention, the following formula (2) constituting the polyorganosiloxane-containing ε-polylysine compound:
-X-Y-Z (2)
X of the group represented by

(In X in Formula (2), R ¹ represents a linear or branched alkylene group having 1 to 5 carbon atoms, an alkenylene group having 2 to 5 carbon atoms, or an arylene group having 6 to 10 carbon atoms.)
It is preferable that it is group represented by these.
In the cosmetic composition according to the first aspect of the present invention, the following formula (2) constituting the polyorganosiloxane-containing ε-polylysine compound:
-X-Y-Z (2)
X of the group represented by

It is preferable that it is group represented by these.
In the cosmetic composition according to the first aspect of the present invention, the following formula (2) constituting the polyorganosiloxane-containing ε-polylysine compound:
-X-Y-Z (2)
X of the group represented by

It is preferable that it is group represented by these.

（式中、ｎは２〜５１の整数である。）で表されることが好ましい。式中のｎは、１０〜４０が好ましく、３０〜４０がさらに好ましい。
ポリオルガノシロキサンが、ε−ポリリジンのアミノ基と反応しうる官能基を有することが好ましい。
本発明の第２の態様の化粧料組成物においてポリオルガノシロキサンが、エポキシ基を有するポリオルガノシロキサン、カルボン酸もしくはカルボン酸誘導体を有するポリオルガノシロキサン、ハロゲン化アルキル基を有するポリオルガノシロキサン又は不飽和基を有するポリオルガノシロキサンであることが好ましい。
本発明の第２の態様の化粧料組成物において、ポリオルガノシロキサンが、下記式（８）
Ｑ−Ｙ−Ｚ （８）
［式（８）中のＱは、

（式中、Ｒ⁴は炭素数１〜２０の直鎖もしくは分岐鎖のアルキル基又は炭素数６〜１０のアリール基もしくはトリメチルシリル基であり、Ｒ⁵は炭素数１〜５の直鎖もしくは分岐鎖のアルキレン基、炭素数２〜５のアルケニレン基又は炭素数６〜１０のアリーレン基であり、Ｗは塩素、臭素又はヨウ素である。）であり、Ｙは、炭素数１〜１０００の直鎖もしくは分岐鎖のアルキレン基であり、このアルキレン基中の相隣接しない任意のメチレン基は−Ｏ−(エーテル)で置換されていてもよく、Ｚは、下記式（３）又は式（４）

（式（３）及び式（４）中のＲ²及びＲ³は、互いに独立した炭素数１〜２０の直鎖もしくは分岐鎖のアルキル基又は炭素数６〜１０のアリール基であり、cは１〜１０００の整数、dは１〜１０００の整数、eは０〜１０００の整数である。）で表されるポリオルガノシロキサン基である。］
で表されるポリオルガノシロキサンであることが好ましい。
ここで、式（８）中のＱは、特に

が好ましい。これらの中でも、

が最も好ましい。
また、式（８）中のＺ中のＲ²とＲ³は、それぞれ互いに独立して、炭素数１〜１０のアルキル基、または炭素数６〜１０のアリール基が好ましく、炭素数１〜５のアルキル基、またはフェニル基がさらに好ましい。これらの中でも、メチル基、n-ブチル基、がもっとも好ましい。 The second aspect of the present invention is a polyorganosiloxane-containing ε-polylysine compound obtained by reacting ε-polylysine with polyorganosiloxane, or one or more physiologically acceptable salts thereof, It is a cosmetic composition containing a monohydric alcohol.
In the cosmetic composition according to the second aspect of the present invention, ε-polylysine is represented by the following formula (7):

(Wherein n is an integer of 2 to 51). N in the formula is preferably 10 to 40, more preferably 30 to 40.
The polyorganosiloxane preferably has a functional group capable of reacting with the amino group of ε-polylysine.
In the cosmetic composition of the second aspect of the present invention, the polyorganosiloxane is an polyorganosiloxane having an epoxy group, a polyorganosiloxane having a carboxylic acid or a carboxylic acid derivative, a polyorganosiloxane having a halogenated alkyl group, or unsaturated. A polyorganosiloxane having a group is preferred.
In the cosmetic composition according to the second aspect of the present invention, the polyorganosiloxane has the following formula (8):
QYZ (8)
[Q in Formula (8) is

(In the formula, R ⁴ is a linear or branched alkyl group having 1 to 20 carbon atoms, or an aryl group or trimethylsilyl group having 6 to 10 carbon atoms, and R ⁵ is a linear or branched chain having 1 to ⁵ carbon atoms. An alkylene group, an alkenylene group having 2 to 5 carbon atoms, or an arylene group having 6 to 10 carbon atoms, and W is chlorine, bromine, or iodine.) And Y is a straight chain having 1 to 1000 carbon atoms or A branched alkylene group, and any non-adjacent methylene group in the alkylene group may be substituted with —O— (ether), and Z represents the following formula (3) or formula (4):

(R ² and R ^{3 in} Formula (3) and Formula (4) are each independently a linear or branched alkyl group having 1 to 20 carbon atoms or an aryl group having 6 to 10 carbon atoms, and c is An integer of 1-1000, d is an integer of 1-1000, and e is an integer of 0-1000. ]
It is preferable that it is polyorganosiloxane represented by these.
Here, Q in formula (8) is

Is preferred. Among these,

Is most preferred.
R ² and R ^{3 in} Z in formula (8) are each independently preferably an alkyl group having 1 to 10 carbon atoms or an aryl group having 6 to 10 carbon atoms, and 1 to 5 carbon atoms. Of these, an alkyl group or a phenyl group is more preferable. Among these, a methyl group and an n-butyl group are most preferable.

（式中、ｎは２〜５１の整数である。）で表されることが好ましい。
本発明の第３の態様の化粧料組成物において、ポリオルガノシロキサンが、ε−ポリリジンのアミノ基と反応しうる官能基を有することが好ましい。
本発明の第３の態様の化粧料組成物において、ポリオルガノシロキサンが、エポキシ基を有するポリオルガノシロキサン、カルボン酸もしくはカルボン酸誘導体を有するポリオルガノシロキサン、ハロゲン化アルキル基を有するポリオルガノシロキサン又は不飽和基を有するポリオルガノシロキサンであることが好ましい。
本発明の第３の態様の化粧料組成物において、ポリオルガノシロキサンが、下記式（８）
Ｑ−Ｙ−Ｚ （８）
［式（８）中のＱは、

（式中、Ｒ⁴は炭素数１〜２０の直鎖もしくは分岐鎖のアルキル基又は炭素数６〜１０のアリール基もしくはトリメチルシリル基であり、Ｒ⁵は炭素数１〜５の直鎖もしくは分岐鎖のアルキレン基、炭素数２〜５のアルケニレン基又は炭素数６〜１０のアリーレン基であり、Ｗは塩素、臭素又はヨウ素である。）であり、Ｙは、炭素数１〜１０００の直鎖もしくは分岐鎖のアルキレン基であり、このアルキレン基中の相隣接しない任意のメチレン基は−Ｏ−(エーテル)で置換されていてもよく、Ｚは、下記式（３）又は式（４）

（式（３）及び式（４）中のＲ²及びＲ³は、互いに独立した炭素数１〜２０の直鎖もしくは分岐鎖のアルキル基又は炭素数６〜１０のアリール基であり、cは１〜１０００の整数、dは１〜１０００の整数、eは０〜１０００の整数である。）で表されるポリオルガノシロキサン基である。］
で表されるポリオルガノシロキサンであることが好ましい。
ここで、式（８）中のＱは、特に

が好ましい。これらの中でも、

が最も好ましい。
また、式（８）中のＺ中のＲ²とＲ³は、それぞれ互いに独立して、炭素数１〜１０のアルキル基、または炭素数６〜１０のアリール基が好ましく、炭素数１〜５のアルキル基、またはフェニル基がさらに好ましい。これらの中でも、メチル基、n-ブチル基、がもっとも好ましい。 The third aspect of the present invention is a polyorganosiloxane-containing ε-polylysine compound obtained by reacting ε-polylysine with polyorganosiloxane, or one or more of its physiologically acceptable salts, It is a manufacturing method of the cosmetic composition which mixes a polyhydric alcohol.
In the cosmetic composition according to the third aspect of the present invention, ε-polylysine is represented by the following formula (7):

(Wherein n is an integer of 2 to 51).
In the cosmetic composition of the third aspect of the present invention, the polyorganosiloxane preferably has a functional group capable of reacting with the amino group of ε-polylysine.
In the cosmetic composition according to the third aspect of the present invention, the polyorganosiloxane is a polyorganosiloxane having an epoxy group, a polyorganosiloxane having a carboxylic acid or a carboxylic acid derivative, a polyorganosiloxane having a halogenated alkyl group or a non-organosiloxane. A polyorganosiloxane having a saturated group is preferred.
In the cosmetic composition of the third aspect of the present invention, the polyorganosiloxane has the following formula (8):
QYZ (8)
[Q in Formula (8) is

(In the formula, R ⁴ is a linear or branched alkyl group having 1 to 20 carbon atoms, or an aryl group or trimethylsilyl group having 6 to 10 carbon atoms, and R ⁵ is a linear or branched chain having 1 to ⁵ carbon atoms. An alkylene group, an alkenylene group having 2 to 5 carbon atoms, or an arylene group having 6 to 10 carbon atoms, and W is chlorine, bromine, or iodine.) And Y is a straight chain having 1 to 1000 carbon atoms or A branched alkylene group, and any non-adjacent methylene group in the alkylene group may be substituted with —O— (ether), and Z represents the following formula (3) or formula (4):

(R ² and R ^{3 in} Formula (3) and Formula (4) are each independently a linear or branched alkyl group having 1 to 20 carbon atoms or an aryl group having 6 to 10 carbon atoms, and c is An integer of 1-1000, d is an integer of 1-1000, and e is an integer of 0-1000. ]
It is preferable that it is polyorganosiloxane represented by these.
Here, Q in formula (8) is

Is preferred. Among these,

Is most preferred.
R ² and R ^{3 in} Z in formula (8) are each independently preferably an alkyl group having 1 to 10 carbon atoms or an aryl group having 6 to 10 carbon atoms, and 1 to 5 carbon atoms. Of these, an alkyl group or a phenyl group is more preferable. Among these, a methyl group and an n-butyl group are most preferable.

［式（１）中、Ｖは下記式（５）

で表される繰り返し単位１と、下記式（６）

で表される繰り返し単位２が不規則に重合したランダム共重合体、繰り返し単位１と繰り返し単位２が交互に重合した交互共重合体、または、繰り返し単位１のみからなるブロックと繰り返し単位２のみからなるブロックが結合したブロック共重合体であり、繰り返し単位１の繰り返し数aは０〜５０の整数、繰り返し単位２の繰り返し数bは０〜５０の整数及びa＋bは１〜５０の整数であり、Ａ¹は下記式（２）
−Ｘ−Ｙ−Ｚ （２）
｛式（２）中、Ｘは

（式中、Ｒ¹は炭素数１〜５の直鎖もしくは分岐鎖のアルキレン基、炭素数２〜５のアルケニレン基又は炭素数６〜１０のアリーレン基を表す）であり、Ｙは、炭素数１〜１０００の直鎖もしくは分岐鎖のアルキレン基であり、このアルキレン基中の相隣接しない任意のメチレン基は−Ｏ−(エーテル)で置換されていてもよく、Ｚは下記式（３）又は下記式（４）

（式（３）及び式（４）中のＲ²及びＲ³は、互いに独立した炭素数１〜２０の直鎖もしくは分岐鎖のアルキル基又は炭素数６〜１０のアリール基であり、cは１〜１０００の整数、dは１〜１０００の整数、eは０〜１０００の整数である。）で表されるポリオルガノシロキサン基である。｝で表される基であり、Ａ²及びＡ³は互いに独立してアミノ基又は上記式（２）で表される基であり、ａが０の場合にＡ²とＡ³が共にアミノ基であることはない。］
で表されることが好ましい。
ここで、前記繰り返し単位１の繰り返し数aは０〜２０の整数、繰り返し単位２の繰り返し数bは２０〜４０の整数及びa＋bは１０〜４０であることが好ましい。また、a＋bは、３０〜４０であることがさらに好ましい。

式（２）中のＸは、特に

が好ましい。
また、式（２）中のＺ中のＲ²とＲ³は、それぞれ互いに独立して、炭素数１〜１０のアルキル基、または炭素数６〜１０のアリール基が好ましく、炭素数１〜５のアルキル基、またはフェニル基がさらに好ましい。これらの中でも、メチル基、n-ブチル基、がもっとも好ましい。 In the cosmetic composition according to the third aspect of the present invention, the polyorganosiloxane-containing ε-polylysine compound is represented by the following formula (1):

[In the formula (1), V represents the following formula (5)

A repeating unit 1 represented by the following formula (6):

A random copolymer in which the repeating units 2 are irregularly polymerized, an alternating copolymer in which the repeating units 1 and 2 are alternately polymerized, or a block consisting of only the repeating unit 1 and only the repeating unit 2 A block copolymer in which the blocks are combined, the repeating number 1 of the repeating unit 1 is an integer of 0 to 50, the repeating number b of the repeating unit 2 is an integer of 0 to 50, and a + b is an integer of 1 to 50, A ¹ is the following formula (2)
-X-Y-Z (2)
{In Formula (2), X is

(Wherein R ¹ represents a linear or branched alkylene group having 1 to 5 carbon atoms, an alkenylene group having 2 to 5 carbon atoms, or an arylene group having 6 to 10 carbon atoms), and Y represents the number of carbon atoms 1 to 1000 linear or branched alkylene groups, and any non-adjacent methylene group in the alkylene group may be substituted with -O- (ether), and Z is the following formula (3) or Following formula (4)

(R ² and R ^{3 in} Formula (3) and Formula (4) are each independently a linear or branched alkyl group having 1 to 20 carbon atoms or an aryl group having 6 to 10 carbon atoms, and c is An integer of 1-1000, d is an integer of 1-1000, and e is an integer of 0-1000. }, A ² and A ³ are each independently an amino group or a group represented by the above formula (2), and when a is 0, both A ² and A ³ are amino groups Never. ]
It is preferable to be represented by
Here, the repeating number a of the repeating unit 1 is preferably an integer of 0 to 20, the repeating number b of the repeating unit 2 is preferably an integer of 20 to 40, and a + b is preferably 10 to 40. Further, a + b is more preferably 30-40.

X in formula (2) is in particular

Is preferred.
Further, R ² and R ^{3 in} Z in the formula (2) are preferably each independently an alkyl group having 1 to 10 carbon atoms or an aryl group having 6 to 10 carbon atoms, and 1 to 5 carbon atoms. Of these, an alkyl group or a phenyl group is more preferable. Among these, a methyl group and an n-butyl group are most preferable.

In the cosmetic composition according to the first and second aspects of the present invention and the method for producing the third cosmetic composition, the polyhydric alcohol is 1,3-butylene glycol, glycerin, propylene glycol, polyethylene It is preferably at least one selected from the group consisting of glycol, dipropylene glycol, 1,2-pentanediol, 1,5-pentanediol, 1,2-hexanediol, 1,6-hexanediol, mannitol and sorbitol. .
In the cosmetic composition according to the first and second aspects of the present invention and the method for producing the third cosmetic composition, the polyhydric alcohol is ethanediol, diethylene glycol, triethylene glycol, 2-amino- 2-methyl-1,3-propanediol, 1,2-propanediol, 1,3-propanediol, polypropylene glycol, 1,2-butanediol, 1,3-butanediol, 1,4-butanediol, isopentane Diol, pentylene glycol, hexylene glycol, 1,3-pentanediol, 1,4-pentanediol, 1,2,3-pentanetriol, 2,3,4-pentanetriol, 1,3,4-pentanetriol 1,3,5-pentanetriol, 1,3-hexanediol, 1,4-hexanediol, 1,5-hexanediol, 1,2,3-hexanetriol, 1,3,4-hexanetriol, 1 , 3,5-hexanetrio , 1,4,6-hexanetriol, erythritol, pentaerythritol, dipentaerythritol, threitol, arabitol, xylitol, ribitol, galactitol, lactitol, maltitol, inositol, panthenol, laminitol, varienamine, validamine, and validolitol It is preferably 1 or more selected from the group.

  In the cosmetic composition according to the first and second aspects of the present invention and the method for producing the third cosmetic composition, a polyorganosiloxane-containing ε-polylysine compound or a physiologically acceptable salt thereof is used. It is preferable to contain 0.001-20 weight%.

In the cosmetic composition according to the first aspect and the second aspect of the present invention and the method for producing the third cosmetic composition, the cosmetic composition is preferably a hair treatment agent. Hair treatments are hair styling (hair cream, hair spray, hair tonic, hair gel, hair lotion, hair oil, hair essence, hair water, hair wax, hair foam, etc.), shampoo, rinse, treatment, hair blow, hair dye ( Hair color, one-component hair dye, two-component hair dye, etc.), permanent agent (permanent wave agent, hair straightener, wave retention agent, etc.), hair restorer, hair nourishing agent or hair loss prevention agent. preferable.
In the cosmetic composition according to the first and second aspects of the present invention and the method for producing the third cosmetic composition, the cosmetic composition is preferably a skin care cosmetic. The skin care cosmetic is preferably a lotion, a cosmetic liquid, a whitening lotion, an emulsion, a whitening emulsion, a cream, a whitening cream, an ointment, a whitening ointment, a lotion, a whitening lotion, an oil or a pack.
In the cosmetic composition according to the first aspect and the second aspect of the present invention and the method for producing the third cosmetic composition, the cosmetic composition is preferably a makeup cosmetic. The make-up cosmetic is preferably a foundation, liquid foundation, lipstick, lip gloss, eye shadow, white powder, white powder, blusher, eyeliner, mascara or eyebrow.
In the cosmetic composition according to the first and second aspects of the present invention and the method for producing the third cosmetic composition, the cosmetic composition is preferably a skin cleanser. The skin cleanser is preferably a soap, cleansing cream, cleansing lotion, cleansing milk, face wash or body shampoo.
In the cosmetic composition according to the first aspect and the second aspect of the present invention and the method for producing the third cosmetic composition, the cosmetic composition is preferably a finishing cosmetic. The finishing cosmetic is preferably a nail polish. In the cosmetic composition according to the first aspect and the second aspect of the present invention and the method for producing the third cosmetic composition, the cosmetic composition comprises a bath preparation, a patch, a perfume, a dentifrice, A mouthwash or mouthwash is preferred.

In the present specification, unless otherwise specified, an amino group represents —NH ₂ and does not include an amino group having a substituent such as an alkylamino group.

According to a preferred embodiment of the present invention, a cosmetic composition that can be easily used for both emulsified and non-emulsified cosmetics and has excellent antiseptic and antibacterial properties can be provided.
Moreover, according to the other preferable aspect of this invention, the antiseptic effect or antimicrobial effect of the cosmetics composition which has polyorganosiloxane containing (epsilon) -polylysine can be improved, and the usage-amount of antiseptic antimicrobial agent can be reduced.
Furthermore, according to the other preferable aspect of this invention, generation | occurrence | production of the skin irritation and sensitization resulting from antiseptic antibacterial agents etc. can be suppressed, and antiseptic antibacterial agents with high safety | security can be provided.

1. Polyorganosiloxane-containing ε-polylysine The polyorganosiloxane-containing ε-polylysine contained in the cosmetic composition of the present invention is a compound represented by the above formula (1). In addition, optical isomers based on all asymmetric carbons generated in the structure of the polyorganosiloxane-containing ε-polylysine represented by the above formula (1) and racemates thereof are also included in the scope of the present invention.

（式（２）のＸ中、Ｒ¹は炭素数１〜５の直鎖もしくは分岐鎖のアルキレン基、炭素数２〜５のアルケニレン基又は炭素数６〜１０のアリーレン基を表す。）
で表される基である。 The following formula (2) constituting the polyorganosiloxane-containing ε-polylysine compound of the above formula (1)
-X-Y-Z (2)
The group represented by X of the group represented by

(In X in Formula (2), R ¹ represents a linear or branched alkylene group having 1 to 5 carbon atoms, an alkenylene group having 2 to 5 carbon atoms, or an arylene group having 6 to 10 carbon atoms.)
It is group represented by these.

Here, R ¹ of X in the formula (2) represents a linear or branched alkylene group having 1 to 5 carbon atoms, an alkenylene group having 2 to 5 carbon atoms, or an arylene group having 6 to 10 carbon atoms. Examples of the alkylene group having 1 to 5 carbon atoms include —CH ₂ CH ₂ —, —CH ₂ —CH (CH ₃ ) —, —CH ₂ CH (C ₂ H ₅ ) —, —CH (CH ₃ ) — Examples thereof include linear or branched alkylene groups such as CH (CH ₃ ) —. Further examples of alkenylene group having 2 to 5 carbon atoms, -CH = CH -, - CH 2 -C (= CH 2) -, - CH = C (CH 3) -, - C (CH 3) = C Examples thereof include linear or branched alkenylene groups such as (CH ₃ )-. Examples of the arylene group having 6 to 10 carbon atoms include 1,2-phenylene, 4-methyl-1,2-phenylene, dimethyl-1,2-phenylene, 4-ethyl-1,2-phenylene, and the like. It is done. In R ^1, particularly preferably _{-CH 2 CH 2 -, - CH} = CH -, - CH 2 -C (= CH 2) -, - CH = C (CH 3) -, and is 1,2-phenylene .

Y in Formula (2) is a linear or branched alkylene group having 1 to 1000 carbon atoms, and any methylene group that is not adjacent to the alkylene group may be substituted with -O- (ether). Good. Specific examples of Y include ethylene, trimethylene, tetramethylene, pentamethylene, hexamethylene, heptamethylene, octamethylene, nonamethylene, decamethylene, undecamethylene, dodecamethylene, tetradecamethylene, 2-methylethylene, 2-methyltrimethyl Methylene, 2-methyltetramethylene, 2-methylpentamethylene, 2-methylhexamethylene, 2-methylheptamethylene, 2-methyloctamethylene, 2-methylnonamethylene, 2-methyldecamethylene, 2-methylundecamethylene , -OCH ₂ CH ₂ CH _2- , -OCH ₂ CH ₂ OCH ₂ CH ₂ CH _2- , -CH ₂ OCH ₂ CH ₂ CH _2- , or-(OCH ₂ CH ₂ ) _m OCH ₂ CH ₂ CH _2- ,-(OCH (CH ₃ ) CH ₂ ) _m OCH ₂ CH ₂ CH ₂ -,-(OCH ₂ CH (CH ₃ )) _m OCH ₂ CH ₂ CH _2- (m is an integer of 1 or more), etc. Can be mentioned. Particularly preferably, trimethylene, decamethylene, _{2-methylethylene, -OCH 2 CH 2 CH 2 -} , - OCH 2 CH 2 OCH 2 CH 2 CH 2 -, - CH 2 OCH 2 CH 2 CH 2 -, - (OCH 2 CH ₂ ) _m is a group selected from OCH ₂ CH ₂ CH ₂ —.

Z in the formula (2) is a polyorganosiloxane group represented by the above formula (3) or the above formula (4). In formula (3) and formula (4), the linear or branched alkyl group having 1 to 20 carbon atoms represented by R ² and R ³ is specifically a methyl group, an ethyl group, or an n-propyl group. I-propyl group, n-butyl group, i-butyl group, s-butyl group, t-butyl group, pentyl group, neopentyl group, hexyl group, heptyl group, octyl group, nonyl group, decyl group, undecyl group, Examples include dodecyl group, cyclopentyl group, cyclohexyl group, benzyl group, and phenethyl group. Specific examples of the aryl group having 6 to 10 carbon atoms include phenyl group, toluyl group, xylyl group, and ethylphenyl group. Moreover, in Formula (3), c is an integer of 1-1000, In Formula (4), d is an integer of 1-1000 and e is an integer of 0-1000. Among these, c is preferably an integer of 1 to 200, and most preferably an integer of 1 to 100. d is preferably an integer of 1 to 200, and most preferably an integer of 1 to 100. e is preferably an integer of 0 to 200, and most preferably an integer of 0 to 100.

  As the polyorganosiloxane-containing ε-polylysine used in the present invention, a physiologically acceptable salt can also be used in the present invention, specifically, a salt with an inorganic acid or a salt with an organic acid, an acidic amino acid. And the like. Specifically, the salt with inorganic acid includes hydrochloride, hydrofluoride, hydrobromide, nitrate, sulfate, phosphate, perchlorate, hydroiodide, etc. It is done. As salts with organic acids, formate, acetate, trifluoroacetate, fumarate, oxalate, tartrate, maleate, citrate, succinate, malate, mandelate , Ascorbate, lactate, gluconate, methanesulfonate, toluenephosphonate, and benzenesulfonate. Examples of salts with acidic amino acids include aspartic acid and glutamic acid. The polyorganosiloxane-containing ε-polylysine used in the product of the present invention includes both anhydrides and hydrates within the scope of the present invention.

2. Method for Producing Polyorganosiloxane-Containing ε-Polylysine The polyorganosiloxane-containing ε-polylysine represented by the above formula (1) is a polyorganosiloxane having a functional group capable of reacting with the amino group of ε-polylysine and the above formula. It can be obtained by reacting with ε-polylysine represented by (7). That is, it can be obtained by using a part of the amino group of ε-polylysine contained in the repeating unit of the above formula (7) as a polyorganosiloxane group.

The ε-polylysine represented by the formula (7) is produced from either an organic synthesis method or a fermentation method using a microorganism. For example, Streptomyces albulus subsp. Described in Japanese Patent No. 1245361 (Patent Document 2). It can be obtained by culturing lysinopolymerus (Streptomyces albulus subspecies lysinopolymelas) in a medium comprising glucose and an inorganic salt and separating it from the culture solution.
The polymerization degree of ε-polylysine represented by the formula (7) used in the present invention is 2 to 51 [n is an integer of 2 to 51 in the formula (7)], and the polymerization degree is particularly preferably 10 to 40 [formula N in (7) is an integer in the range of 10 to 40], and more preferably, the degree of polymerization is in the range of 30 to 40 [n in the formula (7) is an integer in the range of 30 to 40].

Examples of the polyorganosiloxane having a functional group capable of reacting with the amino group of ε-polylysine include, for example, a polyorganosiloxane having an epoxy group, a polyorganosiloxane having a carboxylic acid or a carboxylic acid derivative, and a polyorgano having a halogenated alkyl group. Examples include siloxane and polyorganosiloxane having an unsaturated group.
Moreover, as a polyorganosiloxane having a functional group capable of reacting with the amino group of ε-polylysine, one-end modified polyorganosiloxane having a functional group at one end, a both-end modified polyorganosiloxane having a functional group at both ends, Mention may be made of side-chain-modified polyorganosiloxanes having functional groups in the side chain.

Specifically, in the present invention, the following formula (8)
-QYZ (8)
The polyorganosiloxane represented by these is preferable.

（式中、Ｒ⁴は炭素数１〜２０の直鎖もしくは分岐鎖のアルキル基又は炭素数６〜１０のアリール基もしくはトリメチルシリル基であり、Ｒ⁵は炭素数１〜５の直鎖もしくは分岐鎖のアルキレン基、炭素数２〜５のアルケニレン基又は炭素数６〜１０のアリーレン基であり、Ｗは塩素、臭素又はヨウ素である。）である。
上記の式（８）のＱで示される基中のＲ⁴は、炭素数1〜20の直鎖もしくは分岐鎖のアルキル基または炭素数6〜10のアリール基もしくはトリメチルシリル基であるが、炭素数1〜20の直鎖もしくは分岐鎖のアルキル基の例としては、メチル基、エチル基、n-プロピル基、i-プロピル基、n-ブチル基、i-ブチル基、s-ブチル基、t-ブチル基、ペンチル基、ネオペンチル基、ヘキシル基、ヘプチル基、オクチル基、ノニル基、デシル基、ウンデシル基、ドデシル基、シクロペンチル基、シクロヘキシル基、ベンジル基、及びフェネチル基等が挙げられる。また炭素数6〜10のアリール基の例としては、フェニル基、トルイル基、キシリル基及びエチルフェニル基等が挙げられる。これらの中でも、Ｒ⁴は特にメチル基、エチル基、n-プロピル基、i-プロピル基、n-ブチル基、トリメチルシリル基が好ましい。
また、上記の式（８）のＱで示される基中のＲ⁵は、上記式（２）中のＸのＲ¹と同様である。
式（８）中のＹとＺは、上記式（２）中のＹとＺと同様である。 Where Q is

(In the formula, R ⁴ is a linear or branched alkyl group having 1 to 20 carbon atoms, or an aryl group or trimethylsilyl group having 6 to 10 carbon atoms, and R ⁵ is a linear or branched chain having 1 to ⁵ carbon atoms. An alkylene group, an alkenylene group having 2 to 5 carbon atoms, or an arylene group having 6 to 10 carbon atoms, and W is chlorine, bromine or iodine.
R ⁴ in the group represented by Q in the above formula (8) is a linear or branched alkyl group having 1 to 20 carbon atoms, an aryl group having 6 to 10 carbon atoms, or a trimethylsilyl group. Examples of 1-20 linear or branched alkyl groups include methyl, ethyl, n-propyl, i-propyl, n-butyl, i-butyl, s-butyl, t- Examples thereof include a butyl group, a pentyl group, a neopentyl group, a hexyl group, a heptyl group, an octyl group, a nonyl group, a decyl group, an undecyl group, a dodecyl group, a cyclopentyl group, a cyclohexyl group, a benzyl group, and a phenethyl group. Examples of the aryl group having 6 to 10 carbon atoms include a phenyl group, a toluyl group, a xylyl group, and an ethylphenyl group. Among these, R ⁴ is particularly preferably a methyl group, an ethyl group, an n-propyl group, an i-propyl group, an n-butyl group, or a trimethylsilyl group.
R ⁵ in the group represented by Q in the above formula (8) is the same as R ¹ of X in the above formula (2).
Y and Z in formula (8) are the same as Y and Z in formula (2).

As described above, the polyorganosiloxane-containing ε-polylysine represented by the above formula (1) is obtained by reacting the ε-polylysine represented by the above formula (7) with the polyorganosiloxane.
The polyorganosiloxane content in the polyorganosiloxane-containing ε-polylysine represented by the above formula (1) is the ratio of the polyorganosiloxane having a functional group capable of reacting with an amino group relative to ε-polylysine and the polyorganosiloxane content. It can be controlled by molecular weight.
The solvent used in the reaction is not particularly limited as long as ε-polylysine is dissolved therein. Specifically, methanol, water and methanol mixed solvent, water and ethanol mixed solvent, water and dimethylformamide mixed solvent, methanol / 2 -Propanol mixed solvent, methanol / ethanol mixed solvent and the like. The reaction solvent is used in an amount of 1 to 100 times, preferably 1 to 10 times the weight of ε-polylysine.
The reaction temperature does not need to be particularly high and proceeds even at room temperature. However, the lower the temperature, the longer the reaction time.

  In addition, this reaction is performed by dissolving ε-polylysine in a solvent and then dropping polyorganosiloxane having a functional group capable of reacting with an amino group. The dropping time is preferably 0.01 to 2 hours. Since the reaction time is a reaction between a functional group and an amino group, the reaction proceeds in a short time, but is preferably 1 to 24 hours. Further, depending on the polyorganosiloxane having a functional group capable of reacting with an amino group to be used, there is a possibility that the polyorganosiloxane does not dissolve in the solvent. Therefore, it is desirable to stir at a sufficient mixing speed. After completion of the reaction, the solvent can be distilled off to obtain polyorganosiloxane-containing ε-polylysine.

3. Cosmetic composition containing polyorganosiloxane-containing ε-polylysine compound or a physiologically acceptable salt thereof and a polyhydric alcohol The polyhydric alcohol used in the present invention is at least a linear, branched or cyclic hydrocarbon. The compound is not particularly limited as long as it is a compound having two or more hydroxyl groups bonded thereto. Specific examples of the polyhydric alcohol used in the present invention include ethanediol, diethylene glycol, triethylene glycol, polyethylene glycol, propylene glycol, dipropylene glycol, 2-amino-2-methyl-1,3-propanediol, 1, 2-propanediol, 1,3-propanediol, polypropylene glycol, 1,3-butylene glycol, 1,2-butanediol, 1,3-butanediol, 1,4-butanediol, isopentanediol, pentylene glycol, Hexylene glycol, 1,2-pentanediol, 1,3-pentanediol, 1,4-pentanediol, 1,5-pentanediol, 1,2,3-pentanetriol, 2,3,4-pentanetriol, 1,3,4-pentanetriol, 1,3,5-pentanetriol, 1,2-hexanediol, 1,3-hexanediol, 1,4-hexanediol 1,5-hexanediol, 1,6-hexanediol, 1,2,3-hexanetriol, 1,3,4-hexanetriol, 1,3,5-hexanetriol, 1,4,6-hexanetriol Glycerin, erythritol, pentaerythritol, dipentaerythritol, threitol, arabitol, xylitol, ribitol, galactitol, sorbitol, mannitol, lactitol, maltitol, inositol, panthenol, laminitol, valenamine, validamine, validatol, ethylene oxide, ethylene Examples include glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, propylene oxide, and 1,5-pentanediol. In particular, 1,3-butylene glycol, propylene glycol, polyethylene glycol, 1,2-pentanediol, 1,2-hexanediol, sorbitol and the like are preferable. In addition, the polyhydric alcohol used in the present invention can be used equally in the state of either an anhydride or a hydrate.

  The polyhydric alcohol used in the present invention can be obtained from various known methods such as organic synthesis methods, extraction and purification methods from natural products, or fermentation methods using microorganisms. These methods are not particularly limited by the method for producing the cosmetic composition of the present invention.

  The polyhydric alcohol used in the present invention may be in any form such as powder, fine crystal, liquid, pellet, mucous, gel, etc., and select the optimal shape for the product form of the cosmetic composition of the present invention. can do.

  The content of the polyhydric alcohol used in the present invention in the cosmetic composition is not particularly limited, but from the viewpoint of the raw material cost of the product and the concentration range where the desired antiseptic antibacterial effect can be exerted, 0.0001 to 80 wt. % Is arbitrarily set within the range of 0.001 to 50% by weight.

The cosmetic composition containing the polyorganosiloxane-containing ε-polylysine compound and the like of the present invention can have any shape such as fine powder, fine crystal, liquid, and pellet according to the product form of the cosmetic composition. You can choose.
The cosmetic composition of the present invention can be mixed with excipients, thickeners, gelling agents, and the like to be adjusted to granules, gels, and viscous liquids.

  The content of the polyorganosiloxane-containing ε-polylysine used in the present invention in the cosmetic composition is not particularly limited, but from the viewpoint of the raw material cost of the product and the concentration range where the desired antiseptic antibacterial effect can be exhibited, It is arbitrarily set within the range of 0.0001 to 50% by weight, and particularly preferably within the range of 0.001 to 20% by weight.

The dosage form of the cosmetic composition constituted in the present invention is arbitrary, and is in the form of capsule, powder, granule, solid, liquid, gel, foam, emulsion, cream, ointment, sheet, It forms dosage forms such as mousse, powder dispersion, multilayer, and aerosol.
Examples of uses of the composition of the present invention include hair styling agents (hair cream, hair spray, hair tonic, hair gel, hair lotion, hair oil, hair essence, hair water, hair wax, hair foam, etc.), shampoo, rinse, Treatments, hair blows, hair dyes (hair color, one-component hair dye, two-component hair dye, etc.), permanent agents (permanent wave agent, hair straightener, wave retention agent, etc.), hair restorer, hair nourishing agent, There are hair treatment agents such as hair loss inhibitors. Further, as other uses of the composition of the present invention, for example, lotion, cosmetic liquid, whitening lotion, milk, whitening milk, cream, whitening cream, ointment, whitening ointment, lotion, whitening lotion, oil, pack, etc. There are skin care cosmetics. Further, other uses of the composition of the present invention include makeup cosmetics such as foundations, liquid foundations, lipsticks, lip glosses, eye shadows, white powders, white powders, blushers, eyeliners, mascaras, eyebrows, and the like. Other uses of the composition of the present invention include skin cleansing agents such as soaps, cleansing creams, cleansing lotions, cleansing milks, cosmetic compositions, facial cleansers, body shampoos and the like. Another application of the composition of the present invention is a finish cosmetic such as a nail polish. Other uses of the composition of the present invention include, for example, bath preparations, patches, perfumes, dentifrices, mouthwashes, and mouthwashes.

4). Additives to be added to cosmetic composition In addition to the polyorganosiloxane-containing ε-polylysine and polyhydric alcohol, which are essential components, the cosmetic composition of the present invention further includes a pigmentation inhibitor and tyrosinase activity exemplified below. Inhibitor, melanocyte melanin production inhibitor, melanin production promoter, moisturizer, cell activator / metabolic activator, antioxidant, active oxygen scavenger / radical production inhibitor, fat metabolism promoter, UV protection agent / UV Absorption enhancers, astringents, anti-inflammatory agents / interleukin production inhibitors / anti-inflammatory agents, antiseborrheic agents, antibacterial agents / antiviral agents, blood flow promoters / vascular stimulants, antiandrogens, structural proteolytic enzymes ( Elastase, collagenase, keratin protease, serine protease, integrin degrading enzyme, involucrin degrading enzyme, filaggrin degrading enzyme, lami Degrading enzymes, fibronectin degrading enzymes, proteoglycan degrading enzymes, etc.) activity inhibitors, structural protein synthesis promoters, mucopolysaccharide (hyaluronic acid, chondroitin sulfate, etc.) degrading enzyme inhibitors, mucopolysaccharide synthesis promoters, intercellular lipid formation Accelerator / Intercellular lipid state improving agent, keratolytic agent / stratum exfoliation promoter, plasminogen activator antagonist inhibitor, Maillard reaction inhibitor, testosterone 5α reductase activity inhibitor / hair papilla activator / hair growth promotion Plants that are preferred for use in forming cosmetic compositions, such as active ingredients, hair matrix inhibitor / hair growth inhibitor, hair swelling agent / hair protectant, odorant elimination agent, etc. Components such as extracts and metabolites derived from raw materials, animal raw materials, microbial raw materials, and other natural product raw materials, or various compounds can be arbitrarily selected and used as additives. The Rukoto, can provide even better cosmetic composition having a functionality of various.
Although content in a formulation is not specifically limited, Usually, the density | concentration range of 0.0001 to 50 weight% is common.

(1) Pigmentation Inhibitor A pigmentation inhibitor can be added to the cosmetic composition of the present invention. Specific examples of pigmentation inhibitors include p-aminobenzoic acid derivatives, salicylic acid derivatives, benzenesulfonamide derivatives, imidazole derivatives, naphthalene derivatives, hydroxyanthranilic acid or salts thereof, and derivatives thereof, anthranilic acid derivatives, coumarin derivatives, amino acids Derivatives (2-amino-3- [1-carboxyl-2- (1H-imidazol-4-yl) ethyl] aminobutanoic acid, 2-amino-3- [1-carboxyl-2- (1H-imidazole) -4-yl) ethyl] aminobutanoic acid hydrochloride, 2-amino-3- [1-carboxyl-2- (1H-imidazol-4-yl) ethyl] aminobutanoic acid sodium salt, 2-amino-3- [ 1-carboxyl-2- (1H-imidazol-4-yl) ethyl] aminobutanoic acid potassium salt, etc.), benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor Derivatives, furan derivatives, pyrone derivatives, nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives, ascorbic acid or salts thereof and derivatives thereof (phosphoric acid-magnesium ascorbate, ascorbyl palmitate, ascorbyl dipalmitate, hydroxyprosthelic acid) Phosphorus phosphate, 5-o-α-D-glucopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate sodium salt, L-ascorbic acid phosphate potassium salt, L-ascorbic acid phosphate magnesium salt, L -Ascorbic acid phosphate calcium salt, L-ascorbic acid phosphate aluminum salt, L-ascorbic acid sulfate sodium salt, L-ascorbic acid sulfate potassium salt, L-ascorbic acid sulfate magnesium salt, L-ascorbine Acid sulfate ester calcium salt, L-ascorbate sulfate aluminum salt, L-ascorbate sodium salt, L-ascorbate potassium salt, L-ascorbate magnesium salt, L-ascorbate calcium salt, L-ascorbate aluminum salt, 6-o-α-D-galactopyranosyl-L-ascorbic acid, 2-o-β-D-galactopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid Phosphate sodium salt, L-ascorbic acid sulfate sodium salt, 6-o-acyl ascorbic acid phosphate sodium salt, 6-o-acyl ascorbic acid phosphate ammonium salt, 6-o-acyl ascorbic acid phosphoric acid Ester isopropanolamine salt, 3-o-isopropyl-L-ascorbic acid, 6-o-alkylascorbic acid phosphate Tellurium salt, 6-o-alkylascorbic acid phosphate calcium salt, 6-o-alkylascorbic acid phosphate barium salt, 6-o-alkylascorbic acid phosphate ammonium salt, 6-o-alkylascorbic acid Phosphate monoethanolamine salt, 6-o-alkylascorbic acid phosphate diethanolamine salt, 6-o-alkylascorbic acid phosphate triethanolamine salt, 6-o-alkylascorbic acid phosphate monoisopropanolamine salt 6-o-alkylascorbic acid phosphate diisopropanolamine salt, 6-o-alkylascorbic acid phosphate triisopropanolamine salt, 3-o-glycosyl-L-ascorbic acid, 6-o-β-D- Galactopyranosyl-L-ascorbic acid, ascorbic acid phosphate cholesterol Ester, palmitic acid-L-ascorbyl, isopalmitic acid-L-ascorbyl, dipalmitic acid-L-ascorbyl, diisopalmitic acid-L-ascorbyl, stearic acid-L-ascorbyl, isostearic acid-L-ascorbyl, distearic acid -L-ascorbyl, diisostearic acid-L-ascorbyl, myristic acid-L-ascorbyl, isomyristic acid-L-ascorbyl, dimyristic acid-L-ascorbyl, diisomyristic acid-L-ascorbyl, 2-ethylhexanoic acid- L-ascorbyl, di-2-ethylhexanoic acid-L-ascorbyl, oleic acid-L-ascorbic acid, 2-o-α-D-glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L -Ascorbic acid, 2-o-α-D-maltotriosyl-L-ascorbic acid, 3-o-α-D-glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L-ascorbic acid , 2-o-α-D- Lutotriosyl-L-ascorbic acid, L-ascorbic acid tetraisopalmitate, L-ascorbic acid tetralaurate, L-ascorbate tetra-2-ethylhexanoate, L-ascorbate tetraoleate, 5, 6-isopropylidene-L-ascorbic acid, L-ascorbic acid retinol ester, L-ascorbic acid-DL-tocopherol phosphate ester, L-3-o-ethylascorbic acid, L-ascorbic acid tristearate, L-ascorbine Acid tripalmitate, L-ascorbic acid trioleate, L-ascorbic acid triphosphate, 2-o-ascorbyl cinnamate, 2-o-ascorbyl ferrate, 2-o-ascorbyl caffeate, 2-o-ascorbyl cinna Pate, 2-o- [6-palmitoyl ascorbyl] -4'-acetoxyferrate, DL-α- Coferol-2-L-ascorbic acid phosphoric diester, ascorbic acid inositol binding derivative, ascorbic acid phosphoramide derivative, ascorbyl arbutin conjugate, ascorbyl phosphoryl cholesterol, chromanyl ascorbic acid derivative, ascorbic acid sialic acid derivative, etc.), tocopherol or its Salts and derivatives thereof (α-tocopherol, β-tocopherol, γ-tocopherol, δ-tocopherol, ε-tocopherol, α-tocopheryl retinoate, aminomethylated tocopherol, hydroxymethylated tocopherol, tocopheryl phosphate, tocopherol Acetate, tocopherol nicotinate, tocopherol succinate, tocopherol linoleate, tocopherol orotate, DL-α-tocopheryl glucosi DL-α-tocopheryl maltoside, DL-β-tocopheryl glucoside, DL-β-tocopheryl maltoside, DL-γ-tocopheryl glucoside, DL-γ-tocopheryl maltoside, DL-δ-tocopheryl Glucoside, DL-δ-tocopheryl maltoside, D-α-tocopheryl glucoside, D-α-tocopheryl maltoside, D-β-tocopheryl glucoside, D-β-tocopheryl maltoside, D-γ-toco Ferryl glucoside, D-γ-tocopheryl maltoside, D-δ-tocopheryl glucoside, D-δ-tocopheryl maltoside, L-α-tocopheryl glucoside, L-α-tocopheryl maltoside, L-β- Tocopheryl glucoside, L-β-tocopheryl maltoside, L-γ-tocopheryl glucoside, L-γ-tocopheryl maltoside, L-δ-tocopheryl glucoside, L-δ-tocopheryl maltoside, 1- ( Sulfoethylamino) -3- (α-toco Eleyl-6-Iroxy) propan-2-ol, 1- (Carboxypropylamino) -3- (α-tocopheryl-6-Iroxy) propan-2-ol hydrochloride, S- [3- (α-Toco Ferroyl-6-iroxy) -2-hydroxypropyl] cysteine, S- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl] -γ-glutamylcystenylglycine, N- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl] aspartic acid, N- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl] glutamic acid, etc.), tocotrienol or a salt thereof And derivatives thereof (α-tocotrienol, β-tocotrienol, γ-tocotrienol, δ-tocotrienol, tocotrienol acetate, tocotrienol nicotinate, tocotrienol succinate, tocotrienol linoleate, tocotrienol Orotate), kojic acid or its derivatives (2-methoxymethyl-hydroxy-4H-pyran-4-one, 2-ethoxymethyl-5-hydroxy-4H-pyran-4-one, 2-benzoyloxymethyl-5 -Hydroxy-4H-pyran-4-one, 2-cinnamoyloxymethyl-5-hydroxy-4H-pyran-4-one, 2-phenoxymethyl-5-hydroxy-4H-pyran-4-one, kojic acid Glucose, geranylgeranylacetone, kojic acid monobutyrate, kojic acid monocaprate, kojic acid monopalmitate, kojic acid monostearate, kojic acid monocinnamate, kojic acid monobenzoate, kojic acid dibutyrate, kojic acid dipalmitate, kojic acid distearate , Kojic acid dioleate, etc.), oxybenzone, benzophenone, guaiazulene, shikonin, baicalin or a salt thereof and derivatives thereof Baicalein or a salt thereof and derivatives thereof, berberine or a salt thereof and derivatives thereof, chrysin or a salt thereof and derivatives thereof, apigenin or a salt thereof and derivatives thereof, luteolin or a salt thereof and derivatives thereof, acetetine or a salt thereof and Derivatives thereof, diosmethine or a salt thereof and derivatives thereof, kaempferol or a salt thereof and derivatives thereof, triphorin or a salt thereof and derivatives thereof, astragalin or a salt thereof and derivatives thereof, quercetin or a salt thereof and derivatives thereof Quercitrin or a salt thereof and derivatives thereof, isoquercitrin or a salt thereof and derivatives thereof, rutin or a salt thereof and derivatives thereof, morin or a salt thereof and derivatives thereof, myricetin or a salt thereof And derivatives thereof, myristitrin or a salt thereof and derivatives thereof, dachiscetin or a salt thereof and derivatives thereof, quercetagetin or a salt thereof and derivatives thereof, isorhamnetin or a salt thereof and derivatives thereof, pinocembrin or a salt thereof and derivatives thereof Naringenin or a salt thereof and derivatives thereof, hesperetin or a salt thereof and derivatives thereof, eriodictyol or a salt thereof and derivatives thereof, pinobankin or a salt thereof and derivatives thereof, aromadendrin or a salt thereof and derivatives thereof, Engeritin or a salt thereof and derivatives thereof, taxofolin or a salt thereof and derivatives thereof, astilbine or a salt thereof and derivatives thereof, amperopsin or a salt thereof and derivatives thereof, Spira Oside, kaempferol-7-neohesperidoside, glutathione or salts thereof and derivatives thereof, isoflavone glycosides (6-o-apiosyl puerarin-4'-o-glucoside, 6-o-glucosyl puerarin, 3 '-Hydroxypuerarin-4'-o-glucoside,6-o-apiosyl-3'-hydroxypuerarin, etc.), γ-pyrone glycoside (maltol-3-o- (6'-o-apiosyl) -glucoside, maltol -3-o- (6′-o-apiosyl) -glucoside etc.), isononyl ferrate, ellagic acid or its salts and derivatives thereof (5,4-dimethylellagic acid, 3,3′-dimethylellagic acid, 3,3 ', 4-trimethylellagic acid, 3,3', 4,4'-tetramethyl-5-methoxyellagic acid, 3-ethyl-4-methyl-5-hydroxyellagic acid, amritoside, etc.), lucinol, Onji Saponin, Bacmond Saponin, Ruscogenin, Celicoside, Asian Chicoside Hederin, senegin, benzoic acid anilides (4-hydroxy-N- (2-hydroxyphenyl) benzoic acid amide, 4-hydroxy-N- (3-hydroxyphenyl) benzamide, 4-hydroxy-N- (4-hydroxyphenyl) ) Benzamide, 3,5-di-t-butyl-4-hydroxy-N- (4-hydroxyphenyl) benzamide, 3,5-di-t-butyl-4-hydroxy-N- (3-hydroxyphenyl) benzamide , 3,5-di-t-butyl-4-hydroxy-N- (2-hydroxyphenyl) benzamide, etc.), diphenylpyralin, cyproheptadine, triprolysine, dimethindene, ozagrel, istipendyl, iproheptin, homochlorcyclidine, alimemazine, Bucillamine, oxytosamide, vidarabine, xanthotoxol, phenylmercury hexachlorophene, mercuric oxide, mercuric chloride, hydrogen peroxide, zinc peroxide, fetus (Bovine-derived, porcine-derived, horse-derived, sheep-derived, etc.) extract, almond extract, amaranth extract, octopus extract, lobster extract, okera extract, kofuyou extract, uncaria extract, gaija extract, kako Juyou Extract, Licorice Extract, Gardenia Extract, Kranigean Extract, Clara Extract, Koganebana (Ogon) Extract, Wheat (Wheat) Extract, Rice (Rice) Extract, Korealia Extract, Sidwaya Extract, Sunku Kyu Extract, San Vitro Extract, Sunpens Extract, Silane (Biac Kyu) Extract, Senkyu (River Kyu) Extract, Senna Extract

, Sempukuka extract, Sentsusai extract, Surigatin extract, Nodake (former cucumber) extract, pearl barley (Yokuinin) extract, hamago extract, honey beetle (Vulgaris) extract, Hamamelis extract, palm extract, parietalia extract, safflower ( Safflower extract, Muwa (mulberry white skin) extract, Malvano jardin (bitter ginseng) extract, Purple squirrel extract, Shirobanairis extract, Mukomugi extract, Yashajitsu extract, Hong Kong extract, Waromoko extract (local soil) extract, Yuzuriha extract, Yakoutou An extract, a millipede extract, etc. are mentioned.

(2) Tyrosinase activity inhibitor A tyrosinase activity inhibitor can be added to the cosmetic composition of the present invention. Specific examples of tyrosinase activity inhibitors include ascorbic acid or salts thereof and derivatives thereof (magnesium phosphate-L-ascorbate, ascorbyl palmitate, ascorbyl dipalmitate, hydroxyprophosphate phosphate ascorbate, 5-o-α -D-glucopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate sodium salt, L-ascorbic acid phosphate potassium salt, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid phosphate calcium salt, L-ascorbic acid phosphate aluminum salt, L-ascorbic acid sulfate sodium salt, L-ascorbic acid sulfate potassium salt, L-ascorbic acid sulfate magnesium salt, L-ascorbic acid sulfate calcium salt, L-ascorbic acid Sulfate Stell aluminum salt, L-ascorbic acid sodium salt, L-ascorbic acid potassium salt, L-ascorbic acid magnesium salt, L-ascorbic acid calcium salt, L-ascorbic acid aluminum salt, 6-o-α-D-galactopyrano Sil-L-ascorbic acid, 2-o-β-D-galactopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid phosphate sodium salt, L-ascorbic acid sulfate Ester sodium salt, 6-o-acyl ascorbic acid phosphate sodium salt, 6-o-acyl ascorbic acid phosphate ammonium salt, 6-o-acyl ascorbic acid phosphate isopropanolamine salt, 3-o-isopropyl- L-ascorbic acid, 6-o-alkylascorbic acid potassium ester potassium salt, 6-o-alkylascorbic acid phosphate Steal calcium salt, 6-o-alkyl ascorbic acid phosphate barium salt, 6-o-alkyl ascorbic acid phosphate ammonium salt, 6-o-alkyl ascorbic acid phosphate monoethanolamine salt, 6-o-alkyl Ascorbic acid phosphate diethanolamine salt, 6-o-alkylascorbic acid phosphate triethanolamine salt, 6-o-alkylascorbic acid phosphate monoisopropanolamine salt, 6-o-alkylascorbic acid phosphate diisopropanol Amine salt, 6-o-alkylascorbic acid phosphate triisopropanolamine salt, 3-o-glycosyl-L-ascorbic acid, 6-o-β-D-galactopyranosyl-L-ascorbic acid, phosphorus ascorbate Acid cholesterol ester, palmitic acid-L-ascorbyl, isopa Mycinic acid-L-ascorbyl, dipalmitic acid-L-ascorbyl, diisopalmitic acid-L-ascorbyl, stearic acid-L-ascorbyl, isostearic acid-L-ascorbyl, distearic acid-L-ascorbyl, diisostearic acid-L- Ascorbyl, myristic acid-L-ascorbyl, isomyristic acid-L-ascorbyl, dimyristic acid-L-ascorbyl, diisomyristic acid-L-ascorbyl, 2-ethylhexanoic acid-L-ascorbyl, di-2-ethylhexane Acid-L-ascorbyl, oleic acid-L-ascorbic acid, 2-o-α-D-glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L-ascorbic acid, 2-o-α- D-maltotriosyl-L-ascorbic acid, 3-o-α-D-glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L-ascorbic acid, 2-o-α-D-malto Triosyl-L-ascorbic acid, L-ascorbic acid Trisopalmitic acid ester, L-ascorbic acid tetralauric acid ester, L-ascorbic acid tetra-2-ethylhexanoic acid ester, L-ascorbic acid tetraoleic acid ester, 5,6-isopropylidene-L-ascorbic acid, L- Ascorbic acid retinol ester, L-ascorbic acid-DL-tocopherol phosphate ester, L-3-o-ethylascorbic acid, L-ascorbic acid tristearate, L-ascorbic acid tripalmitate, L-ascorbic acid trioleate, L-ascorbyl triphosphate, 2-o-ascorbyl cinnamate, 2-o-ascorbyl ferrate, 2-o-ascorbyl caffeate, 2-o-ascorbyl cinnamate, 2-o- [6-palmitoyl ascorbyl] -4'-acetoxyferrate, DL-α-tocopherol-2-L-ascorbic acid phosphoric acid diester, Scorbic acid inositol binding derivative, ascorbic acid phosphoramide derivative, ascorbic acid arbutin conjugate, ascorbyl phosphoryl cholesterol, chromanyl ascorbic acid derivative, ascorbic acid sialic acid derivative, etc.), hydroquinone or its salts and derivatives thereof (hydroquinone α-D-glucose , Hydroquinone β-D-glucose, hydroquinone α-L-glucose, hydroquinone β-L-glucose, hydroquinone α-D-galactose, hydroquinone β-D-galactose, hydroquinone α-L-galactose, hydroquinone β-L-galactose, etc. Hexoses, hydroquinone α-D-ribose, hydroquinone β-D-ribose, hydroquinone α-L-ribose, hydroquinone β-L-ribose, hydroquinone α-D-arabinose, hydroquinone β-D-a Five carbon sugar glycosides such as rabinose, hydroquinone α-L-arabinose, hydroquinone β-L-arabinose, hydroquinone α-D-glucosamine, hydroquinone β-D-glucosamine, hydroquinone α-L-glucosamine, hydroquinone β-L- Amino sugar glycosides such as glucosamine, hydroquinone α-D-galactosamine, hydroquinone β-D-galactosamine, hydroquinone α-L-galactosamine, hydroquinone β-L-galactosamine, hydroquinone α-D-glucuronic acid, hydroquinone β-D- Glucuronic acid, hydroquinone α-L-glucuronic acid, hydroquinone β-L-glucuronic acid, hydroquinone α-D-galacturonic acid, hydroquinone β-D-galacturonic acid, hydroquinone α-L-galacturonic acid, hydroquinone β-L-galacturonic acid Hydroquinone glycosides such as uronic acid glycosides Hydroquinone benzyl ether, 4-β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) butane, 5-β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) pentane, 6- β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) hexane, 2-β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) propane, 2-β-D-glucopyra Hydroquinone hydroxyalkyl ether glycosides such as nosyloxy-1- (4-hydroxyphenoxy) butane, 2-β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) propan-3-ol, etc.) Kojic acid or a salt thereof and derivatives thereof (2-methoxymethyl-hydroxy-4H-pyran-4-one, 2-ethoxymethyl-5-hydroxy-4H-pyran-4-one, 2-benzoyloxymethyl- 5-Hydroxy-4H-pyran-4-one, 2-cinnamoyloxymethyl-5-hy Droxy-4H-pyran-4-one, 2-phenoxymethyl-5-hydroxy-4H-pyran-4-one, kojic acid glycoside, geranylgeranylacetone, kojic acid monobutyrate, kojic acid monocaprate, kojic acid monopalmitate , Kojic acid monostearate, kojic acid monocinnamate, kojic acid monobenzoate, kojic acid dibutyrate, kojic acid dipalmitate, kojic acid distearate, kojic acid dioleate, etc.), tocopherol or a salt thereof and derivatives thereof (α-tocopherol, β-tocopherol, γ-tocopherol, δ-tocopherol, ε-tocopherol, α-tocopheryl retinoate, aminomethylated tocopherol, hydroxymethylated tocopherol, tocopheryl phosphate, tocopherol acetate, tocopherol nicotinate Tocopherol succinate, tocopherol linoleate, tocopherol orotate, DL-α-tocopheryl glucoside, DL-α-tocopheryl maltoside, DL-β-tocopheryl glucoside, DL-β-tocopheryl maltoside, DL-γ- Tocopheryl glucoside, DL-γ-tocopheryl maltoside, DL-δ-tocopheryl glucoside, DL-δ-tocopheryl maltoside, D-α-tocopheryl glucoside, D-α-tocopheryl maltoside, D-β -Tocopheryl glucoside, D-β-tocopheryl maltoside, D-γ-tocopheryl glucoside, D-γ-tocopheryl maltoside, D-δ-tocopheryl glucoside, D-δ-tocopheryl maltoside, L- α-tocopheryl glucoside, L-α-tocopheryl maltoside, L-β-tocopheryl glucoside, L-β-tocopheryl maltoside, L-γ-tocopheryl glucoside, L-γ- Coferyl maltoside, L-δ-tocopheryl glucoside, L-δ-tocopheryl maltoside, L- (sulfoethylamino) -3- (α-tocopheryl-6-iroxy) propan-2-ol, 1 -(Carboxypropylamino) -3- (α-tocopheryl-6-iroxy) propan-2-ol hydrochloride, S- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl] Cysteine, S- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl] -γ-glutamylcystenylglycine, N- [3- (α-tocopheryl-6-iroxy) -2 -Hydroxypropyl] aspartic acid, N- [3- (α-tocopheryl-6-yloxy) -2-hydroxypropyl] glutamic acid, etc.), tocotrienol or a salt thereof and derivatives thereof (α-tocotrienol, β-tocotrienol, γ-tocotrienol, δ-tocotrienol, tocotrienol acetate , Tocotrienol nicotinate, tocotrienol succinate, tocotrienol linoleate, tocotrienol orotate, etc.), N-acetyltyrosine or a salt thereof and derivatives thereof, glutathione or a salt thereof and derivatives thereof, ellagic acid or a salt thereof and derivatives thereof (3,4-dimethylellagic acid, 3,3'-dimethylellagic acid, 3,3 ', 4-trimethylellagic acid, 3,3', 4,4'-tetramethyl-5-methoxyellagic acid, 3- Ethyl-4-methyl-5-hydroxyellagic acid, amritosides, etc.), isonitrine A, isonitrine B, isonitrine C, isonitrin D, isonitrinic acid E, isonitrinic acid F, dermadein, tricobylidein and other isonitrile antibiotics, orthoric acid derivatives (Orceric acid, orceric acid ethyl ester orcinol, p-geranylorceric acid, p-gerani Orceric acid ethyl ester geranyl orcinol, p-farnesylorceric acid, p-farnesylorceric acid ethyl ester farnesylorcinol, p-dodecanylorceric acid, p-dodecanylorceric acid ethylester dodecanylorcinol, p -Tetradecanylorceric acid, p-tetradecanylorceric acid ethyl ester tetradecanylorcinol, p-hexadecanylorceric acid, p-hexadecanylorceric acid ethylester hexadecanylorcinol, p -Undecanylorceric acid, p-undecanylorceric acid ethyl ester undecanylorcinol, p-tridecanylorceric acid, p-tridecanylorceric acid ethylester undecanylorcinol, p-penta Decanylorceric acid, p-pentadecanylorserine Ethyl ester pentadecanylorcinol, ethylhexylorceric acid, p-ethylhexylorceric acid ethylester ethylhexylorcinol, p-cyclohexylmethylorceric acid, p-cyclohexylmethylorceric acid ethylester cyclohexylmethylorcinol, p-hydroxy Ethyl hexylorceric acid methyl ester, p-hydroxyethylhexylorceric acid hydroxyethylhexylorcinol, etc.), umbelic acid, brefeldin, oxydesveratrol, resorcinol derivative (4-cyclohexylresorcinol), 3-hydroxyketone compound (1, 5-bis (p-hydroxyphenyl) -2-hydroxypentan-4-one, 1,5-bis (o, p-dihydroxyphenyl) -2-hydroxypentan-4-one, 1,5-bis (p- Hydroxyphenyl-m-meth Ciphenyl) -2-hydroxypentan-4-one), 1,3-diketone compounds (1,5-bis (p-hydroxyphenyl) -2,4-pentanedione, 1,5-bis (o, p- Dihydroxyphenyl) -2,4-pentanedione, 1,5-bis (p-hydroxyphenyl-m-methoxyphenyl) -2,4-pentanedione, etc.), bishydroxybenzylamides, γ-aminobutyric acid or derivatives thereof (N-methyl-γ-aminobutyric acid, N-dimethyl-γ-aminobutyric acid, γ-aminobutyric acid oleyl ester, etc.), hydrogen peroxide, zinc peroxide, placenta extract, lucinol, silk extract, acacia extract, acerola extract

, Ichibi (winter position) extract, Weeping birch extract, Quercus extract, Chestnut extract, Tortoise extract Extract, chamomile extract, mulberry extract, gardenia extract, pearl millet extract, cracker extract, clara extract, mugwort extract, honeysuckle extract, yellowfin extract, dolphin extract, pine pod extract, pearl barley extract, nettle extract, hop extract, hawthorn extract, eucalyptus extract, yarrow Extract, Altea extract, Keihi extract, Mankeishi extract, Hamamelis extract, Yamaguchi extract, Kikyo extract, Toshishi extract, Junyoko extract, Shoot dried extract, Mao extract, Senki Wu Extract, Dokatsu Extract, Psycho Extract, Bow Fufu Extract, Hamabo Fufu Extract, Ogon Extract, Peony Skin Extract, Peonies Extract, Genno Shoko Extract, Kudzu Extract, Licorice Extract, Pyrup Extract, Aloe Extract, Shouma Extract, Safflower Extract, Green Tea Extract, Black Tea Extract, Assen drug extract and the like.

(3) Melanocyte Melanin Production Inhibitor A melanocyte melanin production inhibitor can be added to the cosmetic composition of the present invention. Specific examples of melanocyte melanin production inhibitors include lobeline or lobeline derivatives, liquiritin derivatives (such as liquiritin-α-glucoside, liquiritin-α-maltoside), phenylchroman derivatives, chromone derivatives (2-butylchromone, 2-pentylchromone, 2 -Heptylchromone, 2-nonylchromone, 2-hexadecylchromone, 2- (1-ethylpentyl) chromone, 2-butyl-7-methoxychromone, 2-pentyl-7-methoxychromone, 2-heptyl-7-methoxychromone 2-nonyl-7-methoxychromone, 2-pentadecyl-7-methoxychromone, 2- (1-ethylpentyl) -7-methoxychromone, 7-hydroxy-2-methylchromone, 7-hydroxy-2-butylchromone 7-hydroxy-2-pentylchromone, 7-hydroxy-2-heptylchromone, 7-hydroxy-2-nonylchromone, 7-hydroxy-2-penta Desylchromone, 7-hydroxy-2- (1-ethylpentyl) chromone), azelaic acid derivatives (azelaic acid monoalkyl ester, azelaic acid dialkyl ester, etc.), phosphatidylglucosamine, lysophosphatidylglucosamine, phenylhydroquinone, 3-β-D -Glucopyranosyl manur, 3-β-D-maltopyranosyl manur, substituted amino acid derivatives (DL-N-formyl-3- (1-naphthyl) alanine, DL-N-acetyl-3- (1-naphthyl) ) Alanine, DL-N-propionyl-3- (1-naphthyl) alanine, DL-N-butyryl-3- (1-naphthyl) alanine, DL-N-isobutyryl-3- (1-naphthyl) alanine, DL- N-valeryl-3- (1-naphthyl) alanine, DL-N-isovaleryl-3- (1-naphthyl) alanine, DL-N- (2-methylvaleryl) -3- (1-naphthyl) alanine, DL-N -(3-Methylvaleryl) -3- (1-naphthyl) alanine, DL-N- (4-Methylvaleryl) -3- (1 -Naphthyl) alanine, DL-N-t-butylacetyl-3- (1-naphthyl) alanine, DL-N-pivaloyl-3- (1-naphthyl) alanine, DL-N-caproyl-3- (1-naphthyl) ) Alanine, DL-N- (2-ethylhexanoyl) -3- (1-naphthyl) alanine, DL-N- (2-methylhexanoyl) -3- (1-naphthyl) alanine, DL-N-heptanoyl -3- (1-naphthyl) alanine, DL-N-octanoyl-3- (1-naphthyl) alanine, DL-N- (2-propylpentanoyl) -3- (1-naphthyl) alanine, DL-N- Nonanoyl-3- (1-naphthyl) alanine, DL-N-decanoyl-3- (1-naphthyl) alanine, DL-N-undecanoyl-3- (1-naphthyl) alanine, DL-N-dodecanoyl-3- ( 1-naphthyl) alanine, DL-N-tridecanoyl-3- (1-naphthyl) alanine, DL-N-tetradecanoyl-3- (1-naphthyl) alanine, DL-N-pentadecanoyl-3- (1 -Naphthyl) alanine, DL-N-hexadecanoyl-3- (1-naphthyl) alanine DL-N-heptadecanoyl-3- (1-naphthyl) alanine, DL-N-octadecanoyl-3- (1-naphthyl) alanine, DL-N-nonadecanoyl-DL-3- (1-naphthyl) alanine, DL -N-icosanoyl-3- (1-naphthyl) alanine, DL-N-acryloyl-3- (1-naphthyl) alanine, DL-N-crotoniloyl-3- (1-naphthyl) alanine, DL-N-methacryloyl- 3- (1-naphthyl) alanine, DL-N-vinylacetyl-3- (1-naphthyl) alanine, DL-N-cyclopropanoyl-3- (1-naphthyl) alanine, DL-N- (2-pentenoyl ) -3- (1-naphthyl) alanine, DL-N- (4-pentenoyl) -3- (1-naphthyl) alanine, DL-N- (2-hexenoyl) -3- (1-naphthyl) alanine, DL -N- (3-hexenoyl) -3- (1-naphthyl) alanine, DL-N- (2-methyl-3-pentenoyl) -3- (1-naphthyl) alanine, DL-N-cyclohexenoyl -3- (1-naphthyl) alanine, DL-N- (10-undecenoyl) -3- (1-naphthyl) alanine, D LN-linoleyl-3- (1-naphthyl) alanine, DL-N-hydroxyacetyl-3- (1-naphthyl) alanine, DL-N- (6-hydroxycaproyl) -3- (1-naphthyl) alanine, DL-N- (8-hydroxyoctanoyl) -3- (1-naphthyl) alanine, DL-N- (9-hydroxynonanoyl) -3- (1-naphthyl) alanine, DL-N- (10-hydroxy Decanoyl) -3- (1-naphthyl) alanine, DL-N- (11-hydroxyundecanoyl) -3- (1-naphthyl) alanine, DL-N- (12-hydroxydecanoyl) -3- ( 1-naphthyl) alanine, DL-N-benzoyl-3- (1-naphthyl) alanine, DL-N- (2-hydroxybenzoyl) -3- (1-naphthyl) alanine, DL-N- (3-hydroxybenzoyl ) -3- (1-naphthyl) alanine, DL-N- (4-hydroxybenzoyl) -3- (1-naphthyl) alanine, DL-N- (o-toluyl) -3- (1-naphthyl) alanine, DL-N- (m-Toluyl) -3- (1-naphthyl) alanine, DL-N- (p-Toluyl) -3- (1-naphthyl) ara DL-N- (1-naphthyl) -3- (1-naphthyl) alanine, DL-N- (2-naphthyl) -3- (1-naphthyl) alanine, DL-N- (2-carboxybenzoyl) -3- (1-naphthyl) alanine, DL-N- (3-carboxybenzoyl) -3- (1-naphthyl) alanine, DL-N- (4-carboxybenzoyl) -3- (1-naphthyl) alanine, DL-N- (2-picoline) -3- (1-naphthyl) alanine, DL-N- (3-picoline) -3- (1-naphthyl) alanine, DL-N- (4-picoline) -3- (1-naphthyl) alanine, DL-N-phenylacetyl-3- (1-naphthyl) alanine, DL-N- (2-phenylpropanoyl) -3- (1-naphthyl) alanine, DL-N- (3 -Phenylbutyryl) -3- (1-naphthyl) alanine, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine, DL-N-valeryl-3- (1-naphthyl) alanine, DL -N- (4-methylvaleryl) -3- (1-naphthyl) alaninamide, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine methyl ester DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine ethyl ester, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine propyl ester, DL-N- (4-methylvaleryl ) -3- (1-naphthyl) alanine-N-butyl ester, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine pentyl ester, DL-N- (4-methylvaleryl) -3- ( 1-naphthyl) alanine isopropyl ester, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine isobutyl ester, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine-t- Butyl ester, etc.), benzolactam derivatives, indolactam derivatives, cedrol, guaiool, 1- (4-hydroxyphenthio) -2-propanol, β-lactoglobulin, 2-methoxy-5-methylphenol, 5-ethyl-2 -Methoxyphenol, 5-N-propyl-2-methoxyphenol, 5-N-butyl-2-methoxypheno 5-N-hexyl-2-methoxyphenol, 5-N-heptyl-2-methoxyphenol, 5-N-decyl-2-methoxyphenol, 5- (1,1-dimethylpropyl) -2-methoxy Phenol, 5- (1,1-dimethylbutyl) -2-methoxyphenol, 5- (1,1-dimethylethyl) -2-methoxyphenol, 2-methoxy-5- (1-methylpentyl) phenol, 2- Methoxy-5- (1-methylhexyl) phenol, 2-methoxy-5- (3-methylhexyl) phenol, 2-methoxy-5- (6-methylheptyl) phenol, 5- (1,3-dimethylheptyl) -2-Methoxyphenol, malvelin, ferguinol, sugiol, cryptojaponol, 1,5-bis [p-hydroxyphenyl] -1,4-pentadien-3-one, 1,5-bis [o-hydroxyphenyl]- 1,4-pentadien-3-one, 1,5-bis [2,4-dihydroxyphenyl] -1,4-pentadien-3-one, 1,5-bis [3-mes Xyl-4-hydroxyphenyl] -1,4-pentadien-3-one, haginin, agrimophor, agrimol, hydrangenol or derivatives thereof, alkylresorcinol or derivatives thereof (such as 4-N-butylresorcinol), aristrone, Caramenenes (such as caramenene, 7-hydroxycaramenene, 5-hydroxycaramenene, 7-methoxycaramenene), trans-umberic acid, N-α-benzoyl-L-arginine, N-α-benzoyl-L-arginine ethyl Ester or N-α-benzoyl-L-arginine ethyl ester, 5-methyl-2 (3H) -furanone, 2-butene-4-olide, 2-hydroxymethylfuran, 2,5-dimethyl-4-hydroxy-3 (2H) -furanone, 2-formylfuran, 3-formylfuran, methyl α-furyl ketone, furfuryl acetate, 2-hydroxy-3-methyl-2-cyclopenten-1-one, 2-hydroxy-3,5 -Dimethyl-2-cyclopenten-1-one, 2,5-dimethyl-4-hydroxy-3 (2H) -thiophenone, 2-hydroxy-3-ethyl-2-cyclopenten-1-one, tetronic acid, pentanedione, Iminodibenzyls (2,2'-iminodibenzyl, imipramine, imipramine hydrochloride, desipramine, desipramine hydrochloride, chlorimipramine, trimipramine, etc.), dibenzocycloheptadienes (amitriptyline, amitriptyline hydrochloride, nortriptyline, noxiptylline, etc.), Tetrahydrocopalol glycosides (ketotifen fumarate, labda-8 (17), 13-dien-15-ol, tetrahydromanur, tetrahydrocoparol, tetrahydrocoparol glucoside, tetrahydrocoparol galactoside, tetrahydrocoparol maltoside, Tetrahydrocoparol cellobioside, Tet Lahydrocopalol maltotrioside, etc.), spiro ether compound, piochelin, phenothiazine compound, promethazine, alimemazine, alimemazine tartrate, triflupromazine, levomepromazine, chlorpromazine, cyclandrate, 4-carboxymethyloxybenzoic acid, 4-carboxymethyl Oxy-2-hydroxybenzoic acid, 3- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- (3-carboxypropyl-1-oxy) benzoic acid, 4- (3-carboxypropyl- 1-oxy) -2-hydroxybenzoic acid, 4- (3-carboxypropyl-1-oxy) -2-methoxybenzoic acid, 5- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 4 -(5-carboxypentyl-1-oxy) -2-hydroxybenzoic acid, 6- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- (10-carboxydecane-1 -Oxy) -2-hydroxybenzoic acid, 4- (10-carbamoyldecane-1-oxy) -2-hydroxybenzoic acid, 4- (4-hydroxybutyl-1-oxy) benzoic acid, 4- (4-hydroxy Butyl-1-oxy) -2-hydroxybenzoic acid, 4- (4-acetoxybutyl-1-oxy) benzoic acid, 4- (4-acetoxybutyl-1-oxy) -2-hydroxybenzoic acid, 4- ( 3-Ethoxycarbonylpropyl-1-oxy) -2-hydroxybenzoic acid, 3- (2,3-dihydroxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- (4-methoxybutyl-1-oxy) 2-hydroxybenzoic acid, 4- (2,3-dihydroxypropyl-1-oxy) -2-hydroxybenzoic acid, 4-carboxymethyloxy-2-hydroxybenzoic acid, 3- (3-carboxypropyl-1- Oxy) -2-hydroxybenzoic acid, 4- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 5- (3-carboxypropyl-1-oxy) -2-hydroxy Benzoic acid, 6- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- (5-carboxypentyl-1-oxy) -2-hydroxybenzoic acid, 4- (4-hydroxybutyl-1 -Oxy) -2-hydroxybenzoic acid, 4- (10-carboxydecane-1-oxy) -2-hydroxybenzoic acid, hydroxytrimethylcyclohexanes (2-hydroxy-4- (2,2,6-trimethyl-1) -Yl-cyclohexane) butane, 4- (2,2,6-trimethyl-1-yl-cyclohexane) -1-butene, 4- (2,2,6-trimethyl-1-yl-cyclohexane) -2-butene 4- (2,2,6-trimethyl-1-yl-cyclohexane) butane, 3-methyl-3-hydroxy-5- (2,2,6-trimethyl-1-yl-cyclohexane) pentane, 3-methyl -1-Hydroxy-5- (2,2,6-trimethyl-1-yl-cyclohexane) pentane, 3-methyl-5- (2,2,6-trimethyl-1-yl-cyclohexane) pentane, 3-methyl -1-Hydro Ci-5- (2,2,6-trimethyl-1-yl-cyclohexane) -3-pentene, 3-methyl-3-hydroxy-5- (2,2,6-trimethyl-1-yl-cyclohexane)- 1-pentene, 3-methyl-1-hydroxy-5- (2,2,6-trimethyl-1-yl-cyclohexane) -2-pentene, 2-hydroxy-4- (2,2,6-trimethyl-1 -Mono-, di- or trisaccharide glycosides such as -yl-cyclohexane) butane), escinol, parahydroxycinnamic acid-4- (2,2,6-trimethyl-yl-cyclohexane) -2-butyl ester Monosaccharide, disaccharide or trisaccharide glycoside, ondisaponin, bacmond saponin, ruscogenin, sericoside, asiaticoside, hederin, senegin, 4- (2,2,6-trimethyl-1-yl-cyclohexane) -2 -Keto-butane, 4- (2,2,6-trimethyl-1-yl-6-cyclohexene) -2-keto-butane, 4- (2,2,6-trimethyl-1-yl-cyclohexane) -2 -Keto-3-butene, 4- (2,2 , 6-Trimethyl-1-yl-6-cyclohexene) -2-keto-3-butene (β-ionone), Lp-hydroxyphenyl group

Lysine, Dp-hydroxyphenylglycine, N-benzyloxycarbonyl-Lp-hydroxyphenylglycine, N-benzyloxycarbonyl-Dp-hydroxyphenylglycine, N-benzoyl-Lp-hydroxyphenylglycine, N-benzoyl-Dp-hydroxyphenyl Glycine, N- (p-methoxybenzoyl) -Lp-hydroxyphenylglycine, N- (p-methoxybenzoyl) -Dp-hydroxyphenylglycine, N- (p-hydroxybenzoyl) -Lp-hydroxyphenylglycine, N- ( p-hydroxybenzoyl) -Dp-hydroxyphenylglycine, N-acetyl-Lp-hydroxyphenylglycine, N-acetyl-Dp-hydroxyphenylglycine, N-acetyl-Lp-hydroxyphenylglycine ethyl ester, N-acetyl-Dp- Hydroxyphenylglycine ethyl ester, N-acetyl-Lp-hydroxyphenyl Glycinamide, N-acetyl-Dp-hydroxyphenylglycinamide, Lp-methoxyphenylglycine, Dp-methoxyphenylglycine, Lp-methoxyphenylglycine hydrochloride, Dp-methoxyphenylglycine hydrochloride, 4-hydroxy-3-methoxy- L-phenylglycine, 4-hydroxy-3-methoxy-D-phenylglycine, Lp-hydroxyphenylglycine ethylamide, Dp-hydroxyphenylglycine ethylamide, N-tert-butoxycarbonyl-Lp-hydroxyphenylglycine, N-tert -Butoxycarbonyl-Dp-hydroxyphenylglycine, N-tert-butoxycarbonyl-Lp-methoxyphenylglycine, N-tert-butoxycarbonyl-Dp-methoxyphenylglycine, N-9-fluorenylmethyloxycarbonyl-Lp-methoxy Phenylglycine, N-9-fluorenylmethyloxycarbonyl-D p-methoxyphenylglycine, N-9-fluorenylmethyloxycarbonyl-Lp-methoxyphenylglycine benzyl ester hydrochloride, N-9-fluorenylmethyloxycarbonyl-Dp-methoxyphenylglycine benzyl ester hydrochloride, Lp- Hydroxyphenylglycinamide, Dp-hydroxyphenylglycinamide, Lp-hydroxyphenylglycine allyl ester p-toluenesulfonate, Dp-hydroxyphenylglycine allylester p-toluenesulfonate, Lp-hydroxyphenylglycine benzylester p-toluene Sulfonate, Dp-hydroxyphenylglycine benzyl ester p-toluenesulfonate, Lp-hydroxyphenylglycine ethyl ester, Dp-hydroxyphenylglycine ethyl ester, Lp-hydroxyphenylglycine ethyl ester Hydrochloride, Dp-hydroxyphenylglycine ethyl ester hydrochloride, Lp-hydroxyphenylglycine methyl ester, Dp-hydroxyphenylglycine methyl ester, etc. , Isoeleucerine or 4-β-hydroxyisoeleucerin, eleucerinol, spiroketal derivative (2- (2,4-hexadinylidene) -1,6-dioxaspiro [4.5] dec-3-ene, 2- (2- Hexynylidene) -1,6-dioxaspiro [4.4] non-3-ene, 2-((4-methylphenyl) methylidene) -6,6-dioxaspiro [4.4] non-3-ene, 2- (2-hexenylidene) -6,6-Dioxaspiro [4.5] dec-3-ene, 2- (2-hexenylidene) -1,6-dioxaspiro [4.4] non-3-ene, 2-hexyl-1,6-dioxaspiro [4.4] nonane 2- (2-hexenyl) -1,6-dioxaspir [4] nonane, 2- (2-hexynyl) -1,6-dioxaspiro [4.4] nonane, 2-pentyl-1,6-dioxaspiro [4.4] nonane, 1,6-dioxaspiro [4.4] nonane, 1, 6-dioxaspiro [4.5] decane, 1,7-dioxaspiro [5.5] undecane, 2,3-benzo-4,4-dimethyl-1,6-dioxaspiro [4.4] nonane, 3,4-benzo-2-pentyl- 1,6-dioxaspiro [4.4] nonane, 3,4-benzo-2-hexyl-1,6-dioxaspiro [4.4] nonane, 3,4-benzo-2-octyl-1,6-dioxaspiro [4.4] nonane, 2-hexyl-9,9-dimethyl-1,6-dioxaspiro [4.4] nonane, 2- (2,4-hexadinylidene) -1,6-dioxaspiro [4.4] non-3-ene, etc.), malvalic acid Phosphonic acid derivatives or salts thereof, aspergillomalasmin, aminophosphonic acid derivatives or salts thereof, diphenhydramine or salts thereof, pregnenolone or derivatives thereof, lutein, farnesyl iso Propanol derivatives, hexahydrofarnesyl acetone, 4-benzoylamino-2-hydroxybenzoic acid, 5-benzoylamino-2-hydroxybenzoic acid, 4-benzoylaminobenzoic acid, 4- (1-naphthoylamino) -2-hydroxy Benzoic acid, 5- (1-naphthoylamino) -2-hydroxybenzoic acid, 4- (2-naphthoylamino) -2-hydroxybenzoic acid, 5- (2-naphthoylamino) -2-hydroxybenzoic acid 4- (1-naphthoylamino) benzoic acid, 4- (2-naphthoylamino) benzoic acid, 4-phenylaminocarbonylbenzoic acid, 4-phenylaminocarbonyl-2-hydroxybenzoic acid, 5-phenylaminocarbonyl 2-hydroxybenzoic acid, 4- (1-naphthylaminocarbonyl) benzoic acid, 4- (1-naphthylaminocarbonyl) -2-hydroxybenzoic acid, 5- (1-naphthylaminocarbonyl) -2-hydroxybenzoic acid , 4- (2-Naphth Aminocarbonyl) benzoic acid, 4- (2-naphthylaminocarbonyl) -2-hydroxybenzoic acid, 5- (2-naphthylaminocarbonyl) -2-hydroxybenzoic acid, hexahydrofarnesyl isopropanol derivative, borneol-p-hydroxysilica Cinnamate glucoside, borneol-p-hydroxycinnamic acid maltoside, borneol-p-hydroxycinnamic acid maltotrioside, cinnamic acid-4- (2,2,6-trimethyl-yl-cyclohexane) -2 -Butyl ester derivatives, 2,4-dihydroxybenzophenone, 1- (2,4-dihydroxyphenyl) -ethanone (2 ', 4'-dihydroxyacetophenone), 1- (2,4-dihydroxyphenyl) -1-propanone ( 2 ', 4'-dihydroxypropiophenone), 1- (2,4-dihydroxyphenyl) -1-butanone, 1- (2,4-dihydroxyphenyl) -1-pentanone, 1- (2,4-dihydroxyl Phenyl) -1-hexanone, 1- (2,4-dihydroxyphenyl) -1-heptanone, 1- (2,4-dihydroxyphenyl) -1-octanone, 1- (2,4-dihydroxyphenyl) -1- Nonanone, 1- (2,4-dihydroxyphenyl) -1-decanone, 1- (2,4-dihydroxyphenyl) -1-undecanone, 1- (2,4-dihydroxyphenyl) -1-dodecanone, 1- ( 2,4-dihydroxyphenyl) -1-tetradecanone, 1- (2,4-dihydroxyphenyl) -1-hexadecanone, 1- (2,4-dihydroxyphenyl) -1-octadecanone, 1- (2-hydroxy-4 -Methoxyphenyl) -ethanone (2'-hydroxy-4'-methoxyacetophenone), 1- (2-hydroxy-4-methoxyphenyl) -1-propanone (2'-hydroxy-4'-methoxypropiophenone), 1- (2-hydroxy-4-methoxyphenyl) -1-butanone, 1- (2-hydroxy-4-methoxyphenyl) -1-pentanone, 1- (2-hydroxy-4-methoxy Phenyl) -1-hexanone, 1- (2-hydroxy-4-methoxyphenyl) -1-heptanone, 1- (2-hydroxy-4-methoxyphenyl) -1-octanone, 1- (2-hydroxy-4- Methoxyphenyl) -1-nonanone, 1- (2-hydroxy-4-methoxyphenyl) -1-decanone, 1- (2-hydroxy-4-methoxyphenyl) -1-undecanone, 1- (2-hydroxy-4 -Methoxyphenyl) -1-dodecanone, 1- (2-hydroxy-4-methoxyphenyl) -1-tetradecanone, 1- (2-hydroxy-4-methoxyphenyl) -1-hexadecanone, 1- (2-hydroxy- 4-methoxyphenyl) -1-octadecanone, 1- (4-hydroxy-2-methoxyphenyl) -ethanone (4'-hydroxy-2'-methoxyacetophenone), 1- (4-hydroxy-2-methoxyphenyl)- 1-propanone (4'-hydroxy-2'-methoxypropiophenone), 1- (2,4-dimethoxyphenyl) -ethanone (2 ', 4'-dimethoxyacetate) Phenone), 1- (2,4-dimethoxyphenyl) -1-propanone (2 ′, 4′-dimethoxypropiophenone), lactone derivative (1,6-dioxaspiro [4.4] nonane-2,7-dione, 1 , 6-Dioxaspiro [4.5] decane-2,7-dione, 4-tridecanolide, 4-dodecanolide, 4-undecanolide, 4-decanolide, 4-nonanolide, 4-octanolide, 4-heptanolide, 5-dodecanolide, 5-undecanolide , 5-decanolide, 5-nonanolide, 5-octanolide, 2-undecen-4-olide, 2-decen-4-olide, 2-nonen-4-olide, 2-heptene-4-olide, 2-undecen-5 -Olide, 2-Decene-5-Olide, 2-Nonene-5-Olide, 2-Octene-5-Olide, 4-Methyl-4-Dodecanolide, 4-Methyl-4-Undecanolide, 4-Methyl-4-decanolide 4-methyl-4-nonanolide, 4-methyl-4-heptanolide, 5-methyl-5-dodecanolide, 5-methyl-5-undecanolide, 5- Methyl-5-decanolide, 5-methyl-5-nonanolide, 5-methyl-5-octanolide, 2-methoxycarbonyl-4-dodecanolide, 2-methoxycarbonyl-4-undecanolide, 2-methoxycarbonyl-4-decanolide, 2 -Methoxycarbonyl-4-nonanolide, 2-methoxycarbonyl-4-heptanolide, 2-methoxycarbonyl-5-undecanolide, 2-methoxycarbonyl-5-decanolide, 2-methoxycarbonyl-5-nonanolide, 2-methoxycarbonyl-5 -Octanolide, 2-allyl-4-undecanolide, 2-allyl-5-decanolide, 2-allyl-4-nonanolide, 2-pentyl-4-undecanolide, 2-pentyl-4-nonanolide, 2-methyl-4-undecanolide 2-methyl-4-nonanolide, 2- (4-hydroxybutyl) -4-undecanolide, 2- (4-hydroxybutyl) -4-nonanolide, 2- (4-hydroxybutyl) -5-decanolide, 5- Propyloxy-4 -Pentanolide, 5-allyloxy-4-pentanolide, 5- (2-hydroxyethoxy) -4-pentanolide, 8-hydroxy-4-octanolide, 6-propyloxy-5-hexanolide, 6-allyloxy-5-hexanolide, 6 -(2-hydroxyethoxy) -5-hexanolide, 9-hydroxy-5-nonanolide, etc.), ethinomycin, iriflorental, iriparidal, 2'-8-C-glucosyl-7-methylaloesol coumaroyl ester, 2 '-8-C-Glucosyl-7-methylaloesol cinnamoyl ester, chloropyramine, anise extract, aloe extract, itadori extract Extract, yellow-bellied peony extract, red-crowned cucumber extract (caloron) extract, red fir tree extract, onion yaga extract, oyster extract, o Itadori Extract, Uyaku Extract, Pumpkin Extract, Gama (Amber Yellow) Extract, Kansui (Atsuji) Extract, Buttercup (Sentsukakusa) Extract, Black Moth Extract, Black Spider Extract, Sisal (Sisal Asa) Extract, Saximar Button Kale Extract, Cinnamon Kale Extract , Chinese prunus extract, Oshima cherry extract, Oya cherry extract, Bean cherry extract, Takane cherry extract, Kohigan extract, Sato cherry extract, Zion extract, Palm extract, White vanilla extract, Ginseng extract, Tamshiba (Pepper extract), Daimonji extract, Japanese beetle extract, Toshishi extract, Legume extract, Japanese pear extract, Japanese mugwort extract, Yarrow extract, Chinese cabbage extract, Dill extract, Honey beetle extract , Kingfish extract, human camellia extract, chickpea extract, peony extract, floral blanca extract, hamula extract, sagebrush extract, convolvulus extract, sandalwood extract, ganoderma biloba extract Chinese willow extract, Red willow extract, Pussy willow extract, Inco-rye willow extract, Kinu willow extract, Cory willow extract, Unryu willow extract, Miyama willow extract, Willow willow extract, Japanese willow extract, Japanese red willow extract, Japanese black willow extract Skin) extract, agave extract, blue-green agave extract, fuchlin agave extract, mitsumata extract, aonori extract, usba aonori extract, sugiaonori extract, hira Aonori Extract, Bow Aonori Extract, Hosoeda Aonori Extract, Kombu Extract, Macombu Extract, Resiquib Extract, Hosome Kombu Extract, Mitsushi Kombu Extract, Wakame Extract, Hirome Extract, Aowakame Extract, Hijiki Extract, Hibamata Extract, Umichiwa Extract, Usubamichiwa Extract Vanou Miuchiwa Extract, Akahuba Miuchiwa Extract, Kona Miuchiwa Extract, Okinawa Chiwa Extract, Usyu

Kuchichiwa extract, Etsumiumiuchiwa extract, Toki giraffe extract, Amakusa giraffe extract, Giraffe rhinoceros extract, Juniper ginseng rhinoceros extract, Tsunomata extract, Iburotsu no Mata extract, Maruba no Mata extract, Hirakotoji extract, Sugi nori extract, Shikinori extract, Ginosa extract , Umichiwa extract, Ishimo-Zuku extract, Misjikonbu extract, Atsumi-Mizumbu extract, Isomoku extract, Nagashima-moku extract, Shida-moku extract, Nejimoku extract, Narasamo extract, Mametawala extract, Japanese chestnut extract, Yatsuma-Tamoku extract, Umi-Tranoku extract, Japanese red-bellied extract , Haha moku extract, yoremoku extract, sawtooth extract, plantain extract, mucadeno Extract, Nurassa extract, Cronouraxa extract, Oomkadenori extract, Pine pine extract, Giant scorpion extract, Sponge extract, Fusunagi extract, Himefusunagi extract, Hirohafushitsune extract, Kurosozo extract, Kobsozo extract, Hanesozo extract, Sozonohana extract Examples include Hiba extract, Thira extract, Camote de afran extract, Hamica extract, Pole verde extract, Nabnegro extract, Datura extract, Matsubusa extract, Binankazura extract and the like.

(4) Melanin production promoter A melanin production promoter can be added to the cosmetic composition of the present invention. Specific examples of the melanin production accelerator include salicylic acid or a salt thereof and derivatives thereof (salicylic acid glucoside, salicylic acid fatty acid ester, salicylic acid alcohol ether, salicylic acid amides, etc.), salicyl alcohol or a salt thereof and derivatives thereof, apigenin, and amentoflavone. , Salamander extract, Udo extract, Shishido extract, Nirinso extract, Oak extract, Beef Taxi extract, Cuckoo thistle extract, Gypsophila extract, Gymnema sylvestre extract, Carrion extract, Ginkgo biloba extract, Konronka extract, Sabinryo extract, Jasmine (pine licorice) extract, hollyhock extract, scallop extract, Arabidopsis extract, lily of the valley extract, sow extract, deco extract, eucommia extract, nagii Da (Butcher Bloom) Extract, Teppouri Extract, Tokiwa Mansaku Extract, Nankin Gouze Extract, Elderberry Extract, Nadesico Extract, Mite Willow Extract, Sardine Willow Extract, Morohaya Extract Zakifujime extract, Ryokakou extract, Ajigusa extract, shellfish extract (cockle extract, green mussel extract, oyster extract, European oyster extract, scallop extract, clam extract, clam extract, bakagai extract, ishi mussel extract, red mussel extract, abalone extract, Sazae extract, bi-extract, etc.).

(5) Moisturizing agent A moisturizing agent can be added to the cosmetic composition of the present invention. Specific examples of moisturizers include gum arabic, benzoin rubber, danmar gum, guaiac oil, Irish moss, karaya gum, tragacanth gum, carob gum, quince seed, agar or its derivatives, casein, glucose, galactose, mannose, xylose, fructose, maltose, iso Maltose, cellobiose, gentiobiose, trehalose, cordierbiose, laminaribiose, nigerose, sambubiose, neohesperidose, apiose, hammamellose, streptose, hydroxystreptose, dihydrostreptose, 2-methylerythrose or derivatives thereof, 2-methylerythrono Lactone, micalose, cladinose, accessose, alkanose, olivomai course, chromose, ebamise, vinerose , Sugars such as nogarose, bilenose, nobiose, moenuronic acid, galosamine, cybirosamine, N-acylcansosamine, vancosamine, evanitrose, rubranitrose, tetronitrose, pyralose, α-octose, trioxacalcinose, aldgarose, blastminosin , Trehalose or derivatives thereof, D-mannosamine and derivatives thereof, isomaltoligosaccharide (panose), primeverose or derivatives thereof, dextrin, gelatin, pectin, starch, carrageenan, carboxymethyl chitin or chitosan, alkylene such as ethylene oxide (C2 to C4) ) Oxygenated hydroxyalkyl (C2-C4) chitin or chitosan, low molecular chitin or chitosan, chitosan salt, sulfated chitin or chitosan, phosphorylation Chin or chitosan, alginic acid or salt thereof, hyaluronic acid or salt thereof, chondroitin sulfate or salt thereof, β-1,3-glucan, β-1,4-glucan, β-1,6-glucan, heparin, ethylcellulose, methylcellulose Carboxymethylcellulose, carboxyethylcellulose, sodium carboxyethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, nitrocellulose, crystalline cellulose, hydroxypropylmethylcellulose, polyvinyl alcohol, polyvinylmethylether, polyvinylpyrrolidone, polyvinylmethacrylate, polyacrylate, polyethylene oxide, Polyalkylene oxide such as polypropylene oxide or a crosslinked polymer thereof, carboxyvinyl polymer, polyethyleneimine, Water-soluble polymers such as lumatan sulfate, keratan sulfate, glycerin fatty acid pyrrolidone carboxylic acid esters, glycerin fatty acid acetyl amino acid esters, pyrrolidone carboxylic acid or its salt, polyaspartic acid or its salt, polyglutamic acid or its salt, polylysine Its salts, sodium lactate, hydantoin and its derivatives, Np-vinylbenzyl-D-cellobionamide, Np-vinylbenzyl-D-lactone amide, Np-vinylbenzyl-D-maltonamide, Np-vinylbenzyl-D-glucone Amides, glucosyloxyethyl methacrylate, galactosyloxypropyl acrylate, mannosyloxyethyl methacrylate, glutamyl lysine, glutaurine, 1,2,4-butanetriol, caran-3,4-diol, azoxaponin (3-o- [β-D -Glucopyranosyl-β-D-G Chronopyranosyl] -sophoradiol, 3-o- [β-D-glucopyranosyl-3-D-glucuronopyranosyl] -soyasapogenol B, 3-o- [β-D-glucopyranosyl-β-D-glucurono Pyranosyl] -azuxapogenol, 3-o- [β-D-glucopyranosyl] -28-o- [β-D-glucopyranosyl-β-D-glucopyranosyl] -dipsogenic acid, 3-o- [α- L-rhamnopyranosyl-β-D-glucopyranosyl-β-D-glucuronopyranosyl] -soyasapogenol B, 3-o- [β-D-glucopyranosyl-β-D-glucuronopyranosyl] -29 -o- [β-D-glucopyranosyl-β-D-glucopyranosyl] -azuxapogenol, etc.), Aoki (Aoki) extract, Aogiri extract, Kenashia Ogiri (Akatsuki) extract, Red ginger extract, Red clover extract, Aki larch extract, Aguahe (Omanten palm) extract, Maruba morning glory extract, morning glory (seaweed) extract, Chilla (Chrysanthemum kanna) extract, rape extract, amachazuru extract, Amana (light essence) extract, Ayuyu extract, Hagatetou extract, Higegatetope extract, Senninkoku extract, Sugimorigatetox extract, Hosoaogeito extract, Aogatetox extract, Haribiyu extract, Aozulan extract, Amaranthus hippochondriax extract, Aristolomeria (Yurizuisen) extract, Arcana (alcanna) extract, Algarrobo (cabbage) extract, Aloe vera extract, Rabbit extract (Yellow grass) extract, Yew (first place) extract, Strawberry Extract, Carob Extract, Inazuna (Telexi) Extract, Rice Extract, Inhabitant Extract, Siwa Tobacco (Iwabuchi) Extract, Siwa Hiba Extract, Siwa Pine Extract, Wheat (Chibusa) Extract, Duckweed (Float) Extract, Usvenita Thia mushroom extract, Usvenia mallow extract, Unya de gato (Uncaria) extract, Enokitake mushroom extract, Elingi extract, Pre-lotus eringi extract, Ogata Hakken extract, Oogurma (civil engineering incense) extract, Great blue squirrel (cereal essence) extract, Oka extract, Okazeli (snake bed) extract, okra extract, onidokolo extract, tokoro extract, Nagadokoro (hikai) extract, onionis extract, yuuko extract, oyster extract, cantriso extract, gaku hydrangea extract, cassava sagrada extract, gypsophila extract, Panax ginseng extract, canniwa extract, carnation extract, gerbera extract, camcam (camo duck) extract, color extract, oats extract, karin extract, Kawara-Psycho (compulsed greens), kawajisha extract Kawaranadeshiko (stone bamboo) extract, Ezokawaranadeshiko (buckwheat, buckwheat) extract, Kantaraasa extract, Kikutaniku extract, quinoa (quinoa) extract, cabbage extract, kiwi extract, cucumber extract, gyory (Nishikawa willow, cedar willow) extract, Kiranso ( (Kaneju-no-Kusa) extract, guayule extract, Kusasugikazura (Tenmon Fuyu) extract, Kudzu (Kazunori) extract, kuonjinjin (yellow flower bud) extract, Kupuas extract, Gunba Nazuna (Sekimei, Sekimeishi) extract, Kemponashi (Kigushi) extract, Gekkavidin (Month) Shimoda) extract, Koenen (Huo Ren) extract, coconut extract, cosmos extract, coconut krill extract, rice oil extract, konjac extract, saffron (bancho flower, west safflower) extract, sapodilla extract, sangre degrad (croton) extract, sun Carrot (Ginseng) extract, Shea (Kalite) extract, Cyanoki extract, Shiitake mushroom extract, Shimeji mushroom extract, Japanese shimeji mushroom extract, Shaka shimeji mushroom extract, Hatake shimeji mushroom extract, Oshiroi shimeji mushroom extract, Buna shimeji mushroom extract, Honji messi extract, Shirotamogitake extract, Shimokurene (hot pepper) extract, Saishin extract, cactus Extracts, Janohige (Bakumon Winter) Extract, Shukukonkamiso Extract, Zhangshan Hydrangea (Tsuneyama) Extract, White Rooster Extract, White Clover (Chicken Bone) Extract, Ginkgo Biloba (Mizuka, Mizuka Flower, Shencho Flower) Extract, Watermelon (Saijo) ) Extract, Psychophyllum (Xucho) extract, Subihiyu (Horse tooth extract, Horse tooth soap) extract, Sekkok extract, Sakura Sekkok extract, Koki Sekko extract, Obanase Sekkok extract, Okinawa Sekkok extract, Hon Sekkok extract, Kose Sekko Extract, deer extract, kibanano extract, cedron extract, mallow extract, celery extract, senshinren extract, radish extract, takasaburo extract, tachidokoro extract , Dahlia (tenjiku button) extract, tarwi extract, senkinshi extract, Japanese jujube extract, chankapiedra extract (River cut) extract, corn extract, corn hair (south cocoon) extract, horsetail (wood band) extract, ash (crust) extract, turkey extract, lentil extract, vertical bean (sword bean) extract, jujube (large potato) extract, Navena extract Extract, Namban Karamushi (Hemp) Extract, Niosum Ville Extract, Nikuzuk Extract, Nemunoki Extract, Nebu Extract, Nebi Extract, Nemurioki Extract, Digokubana (Nehu) Extract, Nogateto Extract, Hylinchus Extract, Hauchiwa Extract, Hauchi Bean Extract, Papaya Extract, Pahalobobo Extract, Balata Rubber tree extract, Agaric extract, White-faced agaric extract, Usukimorinokasa extract, Haran extract, Parulis extract, Balsamic extract , Hiba extract, sunflower extract, pepper extract, Himeuzu extract, Himematsutake (Kawariharatake, Hiromatsutake) extract, Citrus soup , Brazilian licorice extract, hazelnut extract, loofah extract, red snapper extract, nettle extract (sparkling) extract, broom extract, duckweed extract, nendo extract, scallop extract, ground beetle extract, spinach (red sap, acute pupa, peony) Extract, Futamata Kokobe Extract, Hosoba Kirinso (Keiten 37) Extract, Jojoba Extract, Borage Extract, Bordeaux Extract, Hononiku (Meat Juice, Daiki) Extract, Honsekkok Extract, Maca Extract, Macadamia Nuts Extract, Margaret (Mokushungiku) Extract, Tamanosen Hallen Extract, Kyukon Kin-Lenka Extract, Matatabi (Kiden Tendon) Extract, Matsukasa Extract, Matsuhodo (Sardine) Extract, Matico (Cordon Sillo) Extract, Quince Extract , Malene (Billow Mow (Zuika) extract, Manzanya (Andesca mitselle) extract, Psyllium serrata extract, Mizusaagao (Dongweed) extract, Green mint extract, Wheat squirrel extract, Munya extract, Murasakiki kibu extract, Omura saxikibu (purple pearl) extract, Murasaki kinafuji (Kunming chicken blood) Wisteria extract, moge extract, cinnamon extract, cornflower extract, yacon extract, coconut extract, yabu tobacco (crane gourd, tennasei) extract, maronier extract, mokka extract, lily extract, ligan (Raimaru) extract, lime extract , Rye extract, sea urchin extract, shallot (apple white) extract, apple extract, gentian extract, litchi (toothpick, toothpick nucleus) extract, lotus root extract, yakuinin extract, mini sasanishiki extract, chlorella vulgaris extract, chlorella pyrenoids Extract, Chlorella ellipsoidia extract, Macrocystis pirifera extract, Yuikiri extract, Tosakanori extract, Cypress extract, Amakusanori extract, Aomidro extract, Kawanori extract, Marimo extract, Motsukikie extract, Ezoyahaz extract, Habanori extract, Habanori extract , Cotton bud extract, sea urchin extract, squirrel extract, trollocomb extract, antokume extract, black arame extract, black currant extract, cat corn extract, Ainu turtle extract, chigaiso extract, squirrel extract, yabane mok extract, trumpet extract, gananomoku extract, joromoku extract, hyamushi extract Moku Extract, Honda Walla Extract, Sugi Moku Extract, Bovine Kenori Extract, Susabi Nori Extract, Akebono Mozuku Extract, Mizoumen extract, Fusanori extract, Hosobanamino Hana extract, Hanafnori extract, Itafonori extract, Kaginori extract, Mirin extract, Hosobamyrin extract, Kikutosaka extract, Ezonameshi extract, Ibaranori extract, Kagyi baranori extract, Japanese red rose extract, Tatyi rose extract, Ogonori Examples include extracts, citrus moss extract, honey beetle extract, red clover extract, red ginseng extract, natto fungus culture metabolite, natto extract, loofah water, birch (white birch) or red pine sap.

(6) Cell activating agent / metabolic activator A cell activating agent / metabolic activator can be added to the cosmetic composition of the present invention. Specific examples of cell activators / metabolites include vitamin A group: retinol or salts thereof and derivatives thereof (retinyl unsaturated fatty acid esters such as retinyl linoleate, retinyl linolenate, retinyl oleate, and retinyl arachidonate) ), Retinal or a salt thereof and derivatives thereof, dehydroretinal or a salt thereof and derivatives thereof, retinoic acid or a salt thereof and derivatives thereof, retinoic acid analog (4-[[[8- (3,5-dimethylphenyl ) -2-Naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (3-methylphenyl) -2-naphthalenyl) carbonyl] amino] benzoic acid, 4-[[[8- (4-methylphenyl) ) -2-Naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2-methylphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (3,4- Dimethylphenyl) -2-naphthaleni ] Carbonyl] amino] benzoic acid, 4-[[[8- (2,4-dimethylphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2-isopropylphenyl) -2 -Naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2-ethylphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2-fluorophenyl) -2 -Naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2-methoxyphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[(8-benzyl-2-naphthalenyl) carbonyl] Amino] benzoic acid, 4-[(E) -2- (8-phenyl-2-naphthalenyl) propenyl] benzoic acid), retinoic acid derivative (4-hydroxyphenylretinamide), retinoid analogue (4-[[( 5,6-dihydro-5,5-dimethyl-8-ethyl-2-naphthalenyl) amino] carbonyl] benzoic acid, 4-[[((5,6-dihydro-5,5,8-trimethyl-2-naphthalenyl) Amino] Kerr Bonyl] benzoic acid, 4-[[(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl) amino] carbonyl] benzoic acid, 4-[[((5,6-dihydro-5, 5-dimethyl-8-ethyl-2-naphthalenyl) carbonyl] amino] benzoic acid, 4-[[(5,6-dihydro-5,5,8-trimethyl-2-naphthalenyl) -carbonyl] amino] benzoic acid, 4- (E)-[2- (5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl) -1-propenyl] benzoic acid, 4-[[((5,6-dihydro-5 , 5-Dimethyl-8-phenyl-2-naphthalenyl) oxy] carbonyl] benzoic acid, 4-[[(5,6-dihydro-5,5-dimethyl-8-phenyl-2- (naphthalenyl) carbonyl] amino] Benzoic acid, 4-[[(5,6-dihydro-5,5-dimethyl-8-phenyl-2- (naphthalenyl) carbonyl] oxy] benzoic acid, 4-[[5,6-dihydro-5,5- Dimethyl-8- (2-fluorophenyl) -naphthalenyl] carbonyl] amino] benzoic acid, 4-[[((5,6-dihydro-5,5,6-trimethyl) ] -8-phenyl-2- (naphthalenyl) carbonyl] amino] benzoic acid, 4-[[(5,6-dihydro-5,5,7-trimethyl-8-phenyl-2-naphthalenyl) carbonyl] benzoic acid, 4-[[((E)-(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] vinyl] benzoic acid, 4-[[[((5,6-dihydro-5,5 -Dimethyl-8-phenyl) -2-naphthalenyl] carbonyl] sulfamyl] benzoic acid, 4-[[[[(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl] sulfamyl] carbonyl] benzoic acid Acid, 4-[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] ethyl] benzoic acid, 4-[[[(5,6-dihydro-5,5-dimethyl -8-phenyl) -2-naphthalenyl] thiocarbonyl] amino] benzoic acid, 4-[[[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] carbonyl] methyl] benzoic acid Acid, 4-[[[((5,6-Dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] methyl] oxy] benzoic acid Acid 4-[[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthenyl] oxy] methyl] benzoic acid, 4-[[[((5,6-dihydro-5, 5-dimethyl-8- (2,4-dimethylphenyl)]-2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8- (4- Methylphenyl)]-2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] ethyl] benzoic acid, 4- [ [[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] sulfamyl] methyl] benzoic acid, 4-[[((5,6-dihydro-5,5-dimethyl-8- Phenyl) -2-naphthalenyl] methyl] amino] benzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] amino] thiocarbonyl] benzoic acid, 4 -[[[((5,6-Dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] methyl] sulfamyl] benzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl - 8-phenyl-2-naphthalenyl] amino] methyl] benzoic acid, 4-[[[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] carbonyl] amino] -2-hydroxy Benzoic acid, 4-[[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] carbonyl] amino] -2-nitrobenzoic acid, 4-[[[((5,6 -Dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] carbonyl] amino] -2-fluorobenzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8-phenyl) -2-Naphthalenyl] carbonyl] amino] -2-methoxybenzoic acid, 4-[[[[(5,6-dihydro-5,5-dimethyl-8- (2-naphthalene)]-2-naphthalenyl] carbonyl] amino ] Benzoic acid, 4-[[(5,6-dihydro-8-phenyl-2-naphthalenyl) carbonyl] aminobenzoic acid, 4-[[((5,6-dihydro-5,5-dimethyl-8-phenyl- 2-Naphthalenyl) carbonyl] amino] -3-fluorobenzoic acid, 4-[[((5,6-dihydro-5,5-dimethyl-8-phenyl) Enyl-2-naphthalenyl) carbonyl] amino] -3-methylbenzoic acid, 4-[[((5,8,10,10a-tetrahydro-10,10-dimethyl-9-phenyl-2-anthracenyl) carbonyl] amino] Benzoic acid, 4-[[(1,1-dimethyl-3-phenyl-1H1-inden-5-yl) amino] carbonyl] benzoic acid, 4-[(1,1-dimethyl-3-phenyl-1H-indene -5-yl-oxymethyl) benzoic acid, 4- [2- (1,1-dimethyl-3-phenyl-1H-inden-5-yl) vinyl] benzoic acid, 4-[(1,1-dimethyl- 3-phenyl-1H-indene-5-carbonyl) amino] benzoic acid), carotene or salts thereof and derivatives thereof (α-carotene, β-carotene, γ-carotene, lycopene, cryptoxanthine, lutein, zeaxanthin, isoseaxanthin, rhodoxanthine , Carotenoids such as capsanthin and crocetin), lycopene or its salts and derivatives thereof, vitamin B group: thiami Or salts thereof and derivatives thereof (thiamine hydrochloride, thiamine disulfide, bisbenchamine, bisbutiamine, thiamine monophosphate disulfide, benfotiamine, chicotiamine, octothiamine, discetiamine, fursultiamine, prosultiamine, astaxanthin Thiamine phosphate diester, etc.), thiamine sulfate, riboflavin or its salts and derivatives thereof (flavin adenine dinucleotide, flavin mononucleotide, riboflavin phosphate diester, 1-β-D-ribofuranosylnicotinamide pyrophosphate diester, 1 -β-D-ribofuranosylnicotinic acid, etc.), pyridoxine or its salts and derivatives thereof (pyridoxine 3,4-dipalmitate, pyridoxine 3,4-dicaprylate, pyridoxine sulfate diester, etc.), pyridoxer Or salts thereof and derivatives thereof, pyridoxamine or salts thereof and derivatives thereof, cyanocobalamin or salts thereof and derivatives thereof, cobalamines (such as methylcobalamin, adenosylcobalamin, hydroxocobalamin, aquacobalamin), folic acid or salts thereof, and Derivatives thereof, nicotinic acid or salts thereof and derivatives thereof, pantothenic acid or salts thereof and derivatives thereof, biotin or salts thereof and derivatives thereof, choline or salts thereof and derivatives thereof, inositol or salts thereof and derivatives thereof , Vitamin C group: ascorbic acid or a salt thereof and derivatives thereof, vitamin D group: ergocalciferol or a salt thereof and derivatives thereof, cholecalciferol and a salt thereof and derivatives thereof (1α-hydroxy-22-[(1 -Hide Xyl-1-methyl) -2-cyclopenten-4-yl-oxy] -23,24,25,26,27-pentanorolecalciferol, [1R, 4R] -1α-hydroxy-22-[(1- Hydroxy-1-methyl) -2-cyclopenten-4-yl-oxy] -23,24,25,26,27-pentanorolecalciferol, [1R, 4S] -1α-hydroxy-22-[(1- Hydroxy-1-methyl) -2-cyclopenten-4-yl-oxy] -23,24,25,26,27-pentanorolecalciferol, [1S, 4R] -1α-hydroxy-22-[(1- Hydroxy-1-methyl) -2-cyclopenten-4-yl-oxy] -23,24,25,26,27-pentanorolecalciferol, [1S, 4S] -1α-hydroxy-22-[(1- Hydroxy-1-methyl) -2-cyclopenten-4-yl-oxy] -23,24,25,26,27-pentanorolecalciferol, etc.), dihydrotaxosterol or a salt thereof and derivatives thereof, vitamin E group : Tocopherol or a salt thereof and derivatives thereof, Tocotrie Nord or a salt thereof and derivatives thereof, ubiquinone or a salt thereof and derivatives thereof, vitamin K group: phytonadione or a salt thereof and derivatives thereof, menaquinone or a salt thereof and derivatives thereof, menadione or a salt thereof and derivatives thereof, menadiol Or salts thereof and derivatives thereof, vitamin F group: linoleic acid or salts thereof and derivatives thereof, linolenic acid or salts thereof and derivatives thereof, arachidonic acid or salts thereof and derivatives thereof, carnitine or salts thereof and Derivatives, ferulic acid or a salt thereof and derivatives thereof, γ-oryzanol or a salt thereof and derivatives thereof, orotic acid or a salt thereof and derivatives thereof, vitamin P group: rutin or a salt thereof and derivatives thereof, eriocitrin or a derivative thereof Salt and it Derivatives, hesperidin or salts thereof and derivatives thereof, vitamin L group: anthranilic acid or salts thereof and derivatives thereof, adenylthiomethylpentose or salts thereof and derivatives thereof, vitamin U group: methylmethionine sulfonium chloride or derivatives thereof , Valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid, hydroxylysine, arginine, ornithine, Histidine or its derivatives (N-octyloxycarbonyl-β-alanyl-L-histidine, N-dodecyloxycarbonyl-β-alanyl-L-histidine, N- (12-amino-1-oxo Dodecyl) -L-histidine, N-2-ethylhexyloxycarbonyl-β-alanyl-L-histidine hydrochloride, N-hexadecyloxycarbonyl-β-alanyl-L-histidine, N-octylaminocarbonyl-β-alanyl- L-histidine, N-dodecylaminocarbonyl-β-alanyl-L-histidine, N-dodecylsulfonyl-β-alanyl-L-histidine, N-dodecylamino-oxalyl-β-alanyl-L-histidine, etc.) Amino acids such as sulfates, phosphates, nitrates, citrates or amino acid derivatives such as pyrrolidone carboxylic acid, α-hydroxy acids such as glycolic acid, citric acid, malic acid, tartaric acid, lactic acid, succinic acid, 2-hydroxycarboxylic acids (methyl lactic acid, 2-hydroxybutanoic acid, 2-hydroxypentanoic acid, 2-hydroxyhexanoic acid, 2-hydroxyheptanoic acid, 2-hydroxy Tannic acid, 2-hydroxynonanoic acid, 2-hydroxydecanoic acid, 2-hydroxyundecanoic acid, α-hydroxylauric acid, α-hydroxymyristic acid, α-hydroxypalmitic acid, α-hydroxystearic acid, α-hydroxyarachidonic acid , Cerebronic acid, α-hydroxynervonic acid, mandelic acid, benzylic acid, phenyllactic acid, atrolactic acid, 2- (4'-hydroxyphenyl) -2-hydroxyethanoic acid, 2- (4'-chlorophenyl) -2-hydroxy Ethanoic acid, 2- (3′-hydroxy-4′-methoxyphenyl) -2-hydroxyethanoic acid, 2- (4′-hydroxy-3′-methoxyphenyl) -2-hydroxyethanoic acid, 3- (2 ′ -Hydroxyphenyl) -2-hydroxypropanoic acid, 3- (4'-hydroxyphenyl) -2-hydroxypropanoic acid, 2- (3 ', 4'-dihydroxyphenyl) -2-hydroxyethanoic acid, glyceric acid, erythrone Acid, ribo Acid, arabinonic acid, xylonic acid, lyxonic acid, aronic acid, altronic acid, gluconic acid, mannonic acid, gulonic acid, idonic acid, galactonic acid, taronic acid, glucoheptonic acid, galactoheptonic acid, tartronic acid, mucinic acid, etc.), poly Hydroxycarboxylic acid or hydroxypolycarboxylic acid (

Gluconolactone, galactonolactone, glucuronolactone, galacturonolactone, gulonolactone, ribonolactone, sugar lactone, pantoyl lactone, glucoheptonolactone, mannonolactone, galactoheptonolactone, etc.), 2-keto acids ( Glyoxylic acid, methyl 2-ketoethanoate, benzoylformic acid, methyl benzoylformate, ethyl benzoylformate, phenylpyruvic acid, methyl phenylpyruvate, ethyl phenylpyruvate, 2-ketobutanoic acid, 2-ketopentanoic acid, 2-ketohexanoic acid, 2 -Ketoheptanoic acid, 2-ketooctanoic acid, 2-ketododecanoic acid, methyl 2-ketooctanoate, etc.), quinic acid, isocitric acid, tropic acid, tretocanic acid, 3-chlorolactic acid, cerebronic acid, citramalic acid, agaricinic acid, aleuricic acid , Pantoic acid, lactobio Acid, hexulosonic acid, photosensitizer 301, hinokitiol, pantothenic acid or derivatives thereof, allantoin, pentadecanoic acid glyceride, linolenic acid or derivatives thereof, eicosapentaenoic acid or derivatives thereof, docosahexaenoic acid or derivatives thereof, estradiol, ethenyl estradiol, anti Allol or its glycoside, Liononiresinol or its glycoside, Rhododendrol or its glycoside, Pratiphyronol or its glycoside, Lactone compound (D-glucurono-6,3-lactone, α-D-gluco Heptonic-γ-lactone, δ-glucuronolactone, α, β-glucooctonic-γ-lactone, L-glonic-γ-lactone, γ-D-galactonolactone, D-saccharide-1,4-lactone , D-saccharide-3,6-lactone, D-ribonic-γ-lactone, α-butyrolactone, -Butyrolactone, α-octanoic lactone, γ-octanoic lactone, nonanoic lactone, γ-valerolactone, D-manninoic-δ-lactone, D-xyloid-δ-lactone, D-arabinoic-δ-lactone, Stearoyl-δ-gluconolactone, DL-pantolactone, palmitoyl-DL-pantolactone, etc.), 3-hydroxy-3,4-dicarboxy-1,4-butanolide or derivatives thereof, 6-benzylaminopurine or derivatives thereof 1,4-diazadicyclooctane, 2,5-dimethylfuran, 2-methylfuran, 2,5-diphenylfuran, 1,3-diphenylisobenzofuran, rutin, tectrigenin 7-xylosyl glucoside, captopril, alacepril , Lisinopril, enalapril, delapril, benazepril, cilazapril, imidapril, quinapril, trandelapri, Lindopril, Temocapril, Losartan, Endothelin, Galactomannan saccharide polymer, Mucin, Trimethylglycine, Proteoglycan, Lactic acid bacteria extract, Lactic acid bacteria extract, Bifidobacterium extract, Bifidobacteria culture extract, Bifidobacterium fermented milk extract, Placenta Extract, reishi extract, spleen extract, thymus extract, yeast extract, yeast culture extract, yeast fermentation extract, filamentous fungus extract, filamentous fungus culture extract, basidiomycetous extract, basidiomycetous culture extract, bacterial cell disruption extract, Bacterial broth extract, cultured human dermal cell disruption extract, red sage extract, fennel scent extract, sorghum sorghum extract, barley extract, barley extract Scutellaria extract, Seyo Hypericum extract, Dutch jellied extract, Dutch honey beetle extract, Silkworm extract, Roman chamomile extract, Garcinia extract, Chinese carrot (blue potato) extract, Kakiran extract, Quillaja extract, Kinlan extract, Ginkgo biloba extract, Calendula extract, Sakaneran extract (Ezosacaneran), Sababagin orchid extract, Sawagurumi (Yamako) extract, Shimotsuke extract, Shajin extract, Plum extract, Prunus extract, Sugina extract, Pineapple extract, Chinese plover extract, Japanese cypress extract, beech extract, physalis (Toro root) Extract, Maitake (Maiko) extract, Misohagi (Chikuma) extract, Mukuge (Kiso) extract, Mukuroji (long life skin) extract, Moyashi extract, Eucalyptus extract, Yukinoshita (tiger ear grass) extract, Suabisimus (cool) , Lettuce (Chisha) extract, aloe extract, dragonfly extract, Tonka bean extract, gentian extract, burdock extract, lion extract, carrot extract, hamamelis extract, hop extract, Yokuinin extract, Japanese apricot extract, assembly extract, Toki extract, Tokinsen extract , Achacha extract, Hypericum extract, Cucumber extract, Ginger extract, Rosemary extract, Parsley extract, Sanadagusa extract, Fukurin amiji extract, Raccoon extract, Oyster comb extract, Onikonbu extract, Gohei comb extract, Nagacomb extract, Pea comb extract, large corn comb extract, rattle extract, brackish rattle extract, benimozuku extract, hosobenimozuku extract, kagekinori extract, ezotosaka extract, Ramoekisu, Kabanoriekisu, and the like.

(7) Antioxidant An antioxidant can be added to the cosmetic composition of the present invention. Specific examples of antioxidants include ascorbic acid or a salt thereof and derivatives thereof (phosphoric acid-magnesium ascorbate, ascorbyl palmitate, ascorbyl dipalmitate, ascorbyl hydroxyprophosphate, 5-o-α -D-glucopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate sodium salt, L-ascorbic acid phosphate potassium salt, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid phosphate calcium salt, L-ascorbic acid phosphate aluminum salt, L-ascorbic acid sulfate sodium salt, L-ascorbic acid sulfate potassium salt, L-ascorbic acid sulfate magnesium salt, L-ascorbic acid sulfate calcium salt, L-ascorbic acid Sulfate aluminum Nium salt, L-ascorbic acid sodium salt, L-ascorbic acid potassium salt, L-ascorbic acid magnesium salt, L-ascorbic acid calcium salt, L-ascorbic acid aluminum salt, 6-o-α-D-galactopyranosyl -L-ascorbic acid, 2-o-β-D-galactopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid phosphate sodium salt, L-ascorbic acid sulfate Sodium salt, 6-o-acyl ascorbic acid phosphate sodium salt, 6-o-acyl ascorbic acid phosphate ammonium salt, 6-o-acyl ascorbic acid phosphate isopropanolamine salt, 3-o-isopropyl-L -Ascorbic acid, 6-o-alkylascorbic acid potassium phosphate, 6-o-alkylascorbic acid phosphate calcium Um salt, 6-o-alkyl ascorbic acid phosphate barium salt, 6-o-alkyl ascorbic acid phosphate ammonium salt, 6-o-alkyl ascorbic acid phosphate monoethanolamine salt, 6-o-alkyl ascorbine Acid phosphate ester diethanolamine salt, 6-o-alkylascorbic acid phosphate triethanolamine salt, 6-o-alkylascorbic acid phosphate monoisopropanolamine salt, 6-o-alkylascorbic acid phosphate diisopropanolamine Salt, 6-o-alkylascorbic acid phosphate triisopropanolamine salt, 3-o-glycosyl-L-ascorbic acid, 6-o-β-D-galactopyranosyl-L-ascorbic acid, ascorbic acid phosphate Cholesterol ester, L-ascorbyl palmitate, L-isopalmitate Scorbyl, L-ascorbyl dipalmitate, L-ascorbyl diisopalmitate, L-ascorbyl stearate, L-ascorbyl isostearate, L-ascorbyl distearate, L-ascorbyl diisostearate, L-ascorbyl myristate, isomyristic acid L-ascorbyl, dimyristic acid L-ascorbyl, diisomyristic acid L-ascorbyl, 2-ethylhexanoic acid L-ascorbyl, di-2-ethylhexanoic acid L-ascorbyl, oleic acid L-ascorbic acid, 2-o-α -D-glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L-ascorbic acid, 2-o-α-D-maltotriosyl-L-ascorbic acid, 3-o-α-D- Glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L-ascorbic acid, 2-o-α-D-maltotriosyl-L-ascorbic acid, L-ascorbic acid tetraisopalmitin Ester, L-Ascorbic acid tetralauric acid ester, L-Ascorbic acid tetra-2-ethylhexanoic acid ester, L-Ascorbic acid tetraoleic acid ester, 5,6-isopropylidene-L-ascorbic acid, L-ascorbic acid retinol Ester, L-ascorbic acid-DL-tocopherol phosphate ester, L-3-o-ethylascorbic acid, L-ascorbic acid tristearate, L-ascorbic acid tripalmitate, L-ascorbic acid trioleate, L-ascorbine Acid triphosphate, 2-o-ascorbyl cinnamate, 2-o-ascorbyl ferrate, 2-o-ascorbyl caffeate, 2-o-ascorbyl synapate, 2-o- [6-palmitoyl ascorbyl] -4 ' -Acetoxyferrate, DL-α-tocopherol-2-L-ascorbic acid phosphate diester, ascorbic acid boar Binding derivatives, ascorbic acid phosphoramide derivatives, ascorbic acid arbutin conjugates, ascorbyl phosphoryl cholesterol, chromanyl ascorbic acid derivatives, ascorbic acid sialic acid derivatives, etc.), stearates, tocopherols or their salts and derivatives thereof (α-tocopherol) , Β-tocopherol, γ-tocopherol, δ-tocopherol, ε-tocopherol, α-tocopheryl retinoate, aminomethylated tocopherol, hydroxymethylated tocopherol, tocopheryl phosphate, tocopherol acetate, tocopherol nicotinate, tocopherol succinate , Tocopherol linoleate, tocopherol orotate, DL-α-tocopheryl glucoside, DL-α-tocopheryl maltoside, DL-β-tocopheryl Glucoside, DL-β-tocopheryl maltoside, DL-γ-tocopheryl glucoside, DL-γ-tocopheryl maltoside, DL-δ-tocopheryl glucoside, DL-δ-tocopheryl maltoside, D-α-toco Ferryl glucoside, D-α-tocopheryl maltoside, D-β-tocopheryl glucoside, D-β-tocopheryl maltoside, D-γ-tocopheryl glucoside, D-γ-tocopheryl maltoside, D-δ- Tocopheryl glucoside, D-δ-tocopheryl maltoside, L-α-tocopheryl glucoside, L-α-tocopheryl maltoside, L-β-tocopheryl glucoside, L-β-tocopheryl maltoside, L-γ -Tocopheryl glucoside, L-γ-tocopheryl maltoside, L-δ-tocopheryl glucoside, L-δ-tocopheryl maltoside, 1- (sulfoethylamino) -3- (α-tocopheryl-6- (Iloxy) propan-2-ol, 1- (carbo Cypropylamino) -3- (α-tocopheryl-6-iroxy) propan-2-ol hydrochloride, S- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl] cysteine, S- [3- (α-Tocopheryl-6-iroxy) -2-hydroxypropyl] -γ-glutamylcystenylglycine, N- [3- (α-tocopheryl-6-iroxy) -2-hydroxy Propyl] aspartic acid, N- [3- (α-tocopheryl-6-yloxy) -2-hydroxypropyl] glutamic acid, etc.), tocotrienol or a salt thereof and derivatives thereof (α-tocotrienol, β-tocotrienol, γ- Tocotrienol, δ-tocotrienol, tocotrienol acetate, tocotrienol nicotinate, tocotrienol succinate, tocotrienol linoleate, tocotrienol orotate), dihydropyridine derivatives (methyl-3- Enyl-2-propenyl 1,4-dihydro-2,6-dimethyl-4- (3-nitrophenyl) pyridine-3,5-dicarboxylate and its salts), benzochroman derivatives, nordihydrogua ceretenoic acid, butyl Hydroxytoluene (BHT), butylhydroxyanisole (BHA), hydroxytyrosol, parahydroxyanisole, coenzyme Qn (n = 7-10), pyrroloquinoline quinone, propyl gallate, sesamol, sesamolin, gossypol, maritimane, sulfretin, xanthene -2,7-diols, caffeoylquinic acids, propolis, carotenoids (α-carotene, β-carotene, γ-carotene, lycopene, lutein, violaxanthin, spiroloxanthine, spheroidene, astaxanthin, etc.), fluorotannin, Akebi extract, Achacha extract, Oolong Chaeki , Dutch biloba extract, kanran extract, kumquat extract, gobishi extract, ginseng extract (old lady's grass) extract, sesame extract, sesame cell extract, sesame extract, ginseng extract, rice bran extract, pomegranate extract, salamander extract, pear Extract, Daio extract, Tomato extract, Nanten extract, Noami (Otsuchi) extract, Neubara extract, Paprika extract, Pistachio extract, Biwa extract, Betel nut extract Buffalo extract, Bokeh extract, Hosobaoguruma extract, Mao (mao) extract, Mimosa extract, Mebouki extract, Himekuma willow extract, Yanagita extract, Watafujitsugi extract , Akaba Miuchiwa extract, Examples include Hypericum extract, Clam extract, Clove extract, Melissa extract, Enmezo extract, Birch extract, Salvia extract, Rosemary extract, Nanten extract, Ginkgo biloba extract, Green tea extract, Clove extract and the like.

(8) Active oxygen scavenger / radical scavenger An active oxygen scavenger / radical scavenger can be added to the cosmetic composition of the present invention. Specific examples of active oxygen scavengers / radical scavengers include superoxide dismutase, catalase, glutathione peroxidase, bilirubin, quercetin, quercitrin, catechin, catechin derivatives, rutin or derivatives thereof, gallic acid or salts thereof and derivatives thereof, curcumin Or salts thereof and derivatives thereof, transferrin, ceruloplasmin, coenzyme Qn (n = 7 to 10), uric acid, bilirubin, metallothionein, stilbengaloyl glycoside (3,5,4′-trihydroxystilbene 4′-o -β-D- (6 "galloyl) glucopyranoside, 3,5,4'-trihydroxystilbene 4'-o-β-D- (2" galloyl) glucopyranoside, etc.), chlorogenic acid phospholipid ester, chlorogenic acid sphingosine ester And derivatives thereof, chlorogenic acid glycolipid ester, chlorogenic acid sugar Steal, chlorogenic acid sterol ester, thiazole derivative or salt thereof (2- (3,4-diethoxyphenyl) -4- (3-carboxy-4-hydroxyphenyl) thiazole, 2- (3,4-diethoxyphenyl) -4- [3-carboxy-4-hydroxy-5- (2-methyl-2-propenyl) phenyl] thiazole and 2- (3,4-diethoxyphenyl) -4- (3-carboxy-4-hydroxy- 5-methylphenyl) thiazole, 2- (3,4-diethoxyphenyl) -4- (3-carboxy-5-methoxyphenyl) thiazole), hydroxymatylesinol, allohydroxymatylesinol, hydantoin derivatives, (Logwood) extract, Akagasiwa (red bud) extract, Acamino red extract, Japanese red plant extract, Japanese red radish extract, Hydrangea (hydrangea) extract, Abemaki extract, Fig extract, Ginkgo biloba extract, Asparagus Extract, Japanese apricot extract, Japanese white extract, Japanese walrus extract, Estragon extract, Enju (Japanese cypress, Japanese rice) extract, Japanese oak (Japanese cypress, Japanese coconut leaf) extract, Japanese cabbage extract, birch extract, birch extract, Kunugi extract, Oleander extract, Kumiko mandarin (Koji, Tachibana, Obenimikan, Fukurikukan, Sagamikoji, Ponkan) extract, Santara extract, Coffee extract, Comfrey extract, Sasa extract, Perilla extract, Aojiso extract, chili mushroom extract, catamen diso extract, peonies (glaze) extract, Japanese oak extract, mizunara extract, crape myrtle extract, dicoppi extract, white birch extract, white clover (clover) extract, horseradish extract, black tea extract, green tea extract, tsububuki Extract, tencha (bamboo tea) extract, tender eel extract, nani waibara (gold cherry tree) extract, peanut (peanut) extract, kei extract, nikkei extract, ceylon nicki extract, yabuni kei (cinnamon) extract, keishi (katsushi) extract, nozenkazura Extract, Lotus (Lotus) Extract, Chinese cabbage extract, Hadamakugi Extract, Hanasuge (Kamika) Extract, Hermanus (Mykai Flower) Extract, Rose (Rose) Extract, Barbasco Extract, Spinach Extract, Beech Extract, American Beech Extract, Dog Beech Extract, European beech extract, Convolvulus extract, Hosobaokera (蒼朮) extract, Button (peony) extract, Mayoram (Annelida) extract, Melon extract, Oenothera extract, Snowy willow extract, Orchid extract, Lacanca extract, Rooibos extract, Naminohana extract, Yukarie Vinegar, bombardier Yukari extract, Azusaekisu, basil extract, woodworking (climate) extract, Hime Fuuro extract, lemon grass extract, and the like.

(9) Fat metabolism promoter A fat metabolism promoter can be added to the cosmetic composition of the present invention. Specific examples of fat metabolism promoters include phthalazine derivatives (4-ethyl-1- (β-hydroxyethylamino) phthalazine, 4-N-propyl-1- (β-hydroxyethylamino) phthalazine, 4-N-butyl- 1- (β-hydroxyethylamino) phthalazine, 4-N-butyl-1- (β-hydroxypropylamino) phthalazine, etc.), xanthine derivatives (caffeine, theophylline, theobromine, xanthine, aminophylline, choline theophylline, diprofylline, proxy) Phyllin and oxtriphilin, etc.) Extract Root) Extract, Ivy Extract, Pepper (Pepper) Extract, Cola Acminata Extract, Sagiomodaka (Sawamata) Extract, Pomelo Extract, Sansyuyu (Yamamuro) Extract, Tsuba Rafuji Extract, Ootsuki Rafuji Extract, Choreimaitake (Amber) Extract, Clover Extract , Prickly pear extract, red ginseng extract, ginseng extract (dragon gall) extract, naginata kouju extract, banana extract, puer tea (common ear tea) extract, plum extract, boufu (windproof) extract and the like.

(10) UV protection agent / UV absorption promoter An UV protection agent / UV absorption promoter can be added to the cosmetic composition of the present invention. Specific examples of UV protection / UV absorption accelerators include benzophenone derivatives (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid, 2-hydroxy-4-methoxybenzophenone-5- Sodium sulfonate, dihydroxydimethoxybenzophenone, dihydroxydimethoxybenzophenone sodium sulfonate, 2,4-dihydroxybenzophenone, tetrahydroxybenzophenone, etc.), 1,2-dihydroxy-4- (2-hydroxyethyl) benzene derivatives (1- (2- (4- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) ethyl-3-hydroxy-4-methoxybenzene, 1- (2- (6- (3,4-dihydroxycinnamoyl) -3- Rhamnosyl) glucosyl) ethyl-3-hydroxy-4-methoxybenzene, 1- (2- (2-acetyl-4- (3,4-dihydroxycinnamoyl) -3-rhamno L) glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- (2-acetyl-6- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- (4- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- (6- (4-hydroxy-3-methoxycinna) Moyl) -3-rhamnosyl) glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- (4- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) -1-methoxyethyl-3, 4-dihydroxybenzene, 1- (2- (4- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) -1-hydroxyethyl-3,4-dihydroxybenzene, 1- (2- (6- (3,4-Dihydroxycinnamoyl) -3-xylosyl) glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- (3-arosyl-6- (3-hydroxy-4-methoxycinnamoyl) ) Glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- (3-glucosyl-6- (3-hydroxy-4-methoxycinnamoyl)) glucosyl) ethyl-3-hydroxy-4-methoxybenzene, 1 -(2- (3-Allosyl-6- (3-hydroxy-4-methoxycinnamoyl) glucosyl) ethyl-3-hydroxy-4-methoxybenzene, 1- (2- (4- (3,4-dihydroxycinna Moyl) glucosyl) ethyl) -3,4-dihydroxybenzene, 1- (2- (3- (3,4-dihydroxycinnamoyl) glucosyl) ethyl) -3,4-dihydroxybenzene, 1- (2- (2 -(3,4-dihydroxycinnamoyl) glucosyl) ethyl) -3,4-dihydroxybenzene, 1- (2- (6- (3,4-dihydroxycinnamoyl) glucosyl) ethyl) -3,4-dihydroxybenzene Paraaminobenzoic acid derivatives (paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, paradimethyla Amyl benzoate, octyl paradimethylaminobenzoate, etc.), methoxycinnamic acid derivatives (ethyl paramethoxycinnamate, isopropyl paramethoxycinnamate, octyl paramethoxycinnamate, 2-ethoxyethyl paramethoxycinnamate, sodium paramethoxycinnamate, paramethoxycinnamic acid Potassium, diparamethoxycinnamate mono-2-ethylhexanoate glyceryl, etc.), anthranilic acid derivatives (such as methyl anthranilate), urocanic acid derivatives (such as urocanic acid, ethyl urocanate), coumarin derivatives, amino acid compounds, benzotriazole derivatives, Tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives, nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives, pyridoxine derivatives, Pyridoxal derivative, pyridoxamine derivative, amethoflavone, neosacranin, 6-dehydrocarbine, triazine derivative (4,4'4 "-(1,3,5-triazine-2,4,6-triyltriimino) trisbenzoic acid tris- 2-ethylhexyl etc.), phosphatidyl chromanol derivatives (1,2-dilaurylglycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman 1,2-dimyristoylglycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1,2-dipalmitoylglycero-3- Phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1,2-distearoylglycero-3-phospho-2'-hydroxymethyl-2', 5 ', 7', 8'-Tetramethyl-6'-hydroxychroman, 1,2-dialachidonylglycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'- Tramethyl-6′-hydroxychroman, 1-myristoyl-2-palmitoylglycero-3-phospho-2′-hydroxymethyl-2 ′, 5 ′, 7 ′, 8′-tetramethyl-6′-hydroxychroman, 1- Myristoyl-2-stearoylglycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1-palmitoyl-2-myristoylglycero-3-phospho -2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1-palmitoyl-2-stearoylglycero-3-phospho-2'-hydroxymethyl-2', 5 ', 7', 8'-tetramethyl-6'-hydroxychroman, 1-stearoyl-2-myristoylglycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetra Methyl-6′-hydroxychroman, 1-stearoyl-2-palmitoylglycero-3-phospho-2′-hydroxymethyl-2 ′, 5 ′, 7 ′, 8′-tetramethyl-6′-hydroxychroman, etc.) , L-carnosine zinc complex, umbelliferone, esculin, benzyl cinnamate, cinoxalate, oxybenzone, dioxybenzone, octabenzone, soribenzone, benzoresorcinol, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, neoheliopan, chlorophylls, xanthophylls , Escalol, Zinc Oxide, Talc, Kaolin, Anthrac (Buckthorn) Extract, Hub Extract, Giant Plover Extract, Asamidori Shigusa Extract, Kawachigusa Extract, Kawatake Extract, Cypridosa Extract, Hassai Extract, Spirulina Extract, Iacashio Extract, Funori no Ushike Extract , Japonica extract, Hytengus extract, Oobusa extract, chinolimo extract and the like.

(11) Astringent An astringent can be added to the cosmetic composition of the present invention. Specific examples of astringents include succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc p-phenolsulfonate, potassium aluminum sulfate, resorcin, ferric chloride, tannins (tannic acid, hamamelitannin Acer tannin, tetragalloyl glucose, pentagalloyl glucose, hexagalloyl glucose, heptagalloyl glucose, octagalloyl glucose, nonagaroyl glucose, decagalloyl glucose, undecagalloyl glucose, dodecagalloyl glucose, etc. Gallotannins, telimaglandin I, telimaglandin II, casarictin, peduncraggin, geraniin, isotarkevin, granatin A, granatin B, ketulinic acid, keblagic acid, casuarinin, nuphalin, procyanidin B-2, Eladitannins such as thiacinensin A and thiacinensin B), red grape extract, red bean extract, altea extract, nettle extract, cascarilla extract, kapoch extract, guarana extract, ezoba strawberry extract, Dutch strawberry extract, shrimp strawberry extract , Nawashiro Strawberry Extract, Maple Strawberry Extract, European Raspberry Extract, Kidney Aloe Extract, Hawthorn Extract, Coustella Hakka Extract, Cowberry (Etsutachibana) Extract, Cola Vera Extract, Sugarcane Extract, Sinah Honoki Extract, Honeysuckle Extract Q) Extract, larch extract, elder extract, dandelion extract, centalium extract, white dandelion extract, mud dandelion extract, vine azuki bean extract, tsurutsu Akebi extract, Teuchigurumi extract, Tormentilla extract, Novara extract, Buttercup extract, Hagoromogusa extract, Castor extract, Grape extract, Prune extract, Veronica extract, Bisnaga extract, Bilberry extract, Mansuguru extract, Mitsugashi extract, Myrrh extract, Melissa extract, Examples include witch hazel extract, black willow extract, latania (chlamelia) extract, lemon extract, and dairy extract.

(12) Anti-inflammatory agent / interleukin production inhibitor / histamine release inhibitor An anti-inflammatory agent / interleukin production inhibitor / histamine release inhibitor can be added to the cosmetic composition of the present invention. Specific examples of anti-inflammatory agents / interleukin production inhibitors / histamine release inhibitors include quinolinone derivatives, dibenzooxepin derivatives, thiotroposin, phthalimide derivatives, flurbiprofen, felbinac, bufexamac, suprofen, 1,4-diphenylpropyl Piperazine derivatives, carxin compounds, chromanol glycosides (2- (α-D-glucopyranosyl) methyl-2,5,7,8-tetramethylchroman-6-ol), ictamol, indomethacin, kaolin, diphenhydramine hydrochloride, d- Camphor, DL-camphor, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, hydrocortisone, guaiazulene, camazulene, chlorpheniramine maleate, diphenhydramine hydrochloride, clemastine fumarate, cyproheptadine hydrochloride, hydrochloric acid Lomethazine, piperazine derivatives, α-D-phenylglycoside derivatives, glycyrrhizic acid or its salts and derivatives thereof (α-glycyrrhizic acid, β-glycyrrhizic acid, α-glycyrrhizic acid methyl ester, β-glycyrrhizic acid methyl ester, α-glycyrrhizin Trisodium acid, monopotassium α-glycyrrhizinate, dipotassium α-glycyrrhizinate, monoammonium α-glycyrrhizinate, trisodium β-glycyrrhizinate, monopotassium β-glycyrrhizinate, dipotassium β-glycyrrhizinate, monoammonium β-glycyrrhizinate ), Glycyrrhetinic acid or a salt thereof, and derivatives thereof (α-glycyrrhetinic acid, β-glycyrrhetinic acid, stearyl α-glycyrrhetinate, stearyl β-glycyrrhetinate, pyridoxine α-glycyrrhetinate, β-glycylretinoic acid Pyridoxine ruretinate, glyceryl α-glycyrrhetinate, glycerin β-glycyrrhetinate, disodium 3-succinyloxyglycyrrhetinate, etc.), mefenamic acid, phenylbutazone, ibuprofen, ketoprofen, allantoin, calcium pantothenate, pantothenyl ethyl ether, etc. Panthenol or salts thereof and derivatives thereof, ε-aminocaproic acid, diclofenac sodium, tranexamic acid or derivatives thereof (trans-4-benzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4-p-nitrobenzyloxycarbonylaminomethylcyclohexane) Carboxylic acid, trans-4-p-chlorobenzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4-p-bromobenzyloxycarbonylaminomethyl Cyclohexanecarboxylic acid, trans-4-m-chlorobenzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4-p-methoxybenzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4-p-methylbenzyloxycarbonylaminomethylcyclohexane Carboxylic acid, sodium trans-4-benzyloxycarbonylaminomethylcyclohexanecarboxylate, ammonium trans-4-p-nitrobenzyloxycarbonylaminomethylcyclohexanecarboxylate, potassium trans-4-p-chlorobenzyloxycarbonylaminomethylcyclohexanecarboxylate Trans-4-p-bromobenzyloxycarbonylaminomethyl potassium cyclohexanecarboxylate, trans-4-m-chlorobenzyloxycarbonylaminomethyl Calcium tilcyclohexanecarboxylate, trans-4-p-methoxybenzyloxycarbonylaminomethyl magnesium cyclohexanecarboxylate, trans-4-p-methylbenzyloxycarbonylaminomethylcyclohexanecarboxylic acid monoethanolamine, trans-4-t-butyloxy Carbonylaminomethylcyclohexanecarboxylic acid, trans-4- (2-phenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (p-biphenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (3, 5-Dimethoxyphenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (p-methylphenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid , Sodium trans-4-t-butyloxycarbonylaminomethylcyclohexanecarboxylate, potassium trans-4- (2-phenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylate, trans-4- (p-biphenylisopropyloxycarbonylaminomethyl) Calcium cyclohexanecarboxylate, trans-4- (3,5-dimethoxyphenylisopropyloxycarbonylaminomethyl) magnesium cyclohexanecarboxylate, trans-4- (p-methylphenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid monoethanolamine, trans -4- (9-fluorenylmethyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4-methylsulfonylethyloxycarbonylaminomethylcyclohexanecarbo Acid, sodium trans-4- (9-fluorenylmethyloxycarbonylaminomethyl) cyclohexanecarboxylate, potassium trans-4-methylsulfonylethyloxycarbonylaminomethylcyclohexanecarboxylate, trans-4- (pyridine-4'-methyl Oxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (2,2,2-trichloroethyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (2-trimethylsilylethoxycarbonylaminomethyl) cyclohexanecarboxylate potassium, trans -4- (pyridine-4'-methyloxycarbonylaminomethyl) cyclohexanecarboxylate sodium, trans-4- (2,2,2-trichloroethyloxycarbonylaminomethyl) cyclohexanecarboxylate potassium, trans-4- (2- Trimethylsilyl Ethoxycarbonylaminomethyl) cyclohexanecarboxylate, etc.), sulfatide, astaxanthin fatty acid diester (astaxanthin dilaurate, astaxanthin dimyristate, astaxanthin dipentadecanoate, astaxanthin dipalmitate, astaxanthin dipalmitoleate, Astaxanthin diheptadecanoic acid ester, astaxanthin dielaidic acid ester, astaxanthin diricinoleic acid ester, astaxanthin petroselinic acid ester, astaxanthin vaccenic acid ester, astaxanthin eleostearic acid ester, astaxanthin punicic acid ester, astaxanthin ricinic acid ester, astaxanthin paris Naphosphate , Astaxanthin gadoric acid ester, astaxanthin 5-eicosenoic acid ester, astaxanthin 5-docosenoic acid ester, astaxanthin cetolic acid ester, astaxanthin erucic acid ester, astaxanthin 5,13-docosadienoic acid ester, astaxanthin ceracholic acid ester, astaxanthin decenoic acid Ester, astaxanthin steric acid ester, astaxanthin dodecenoic acid ester, astaxanthin dioleic acid ester, astaxanthin distearic acid ester, astaxanthin dieicosapentaenoic acid ester, astaxanthin didocosahexaenoic acid ester, astaxanthin dilinolenic acid ester, astaxanthin dilinolenic acid ester, astaxanthin diester Arachidonic acid ester ), Astaxanthin diglycerophosphate (astaxanthin diglycerophosphate, astaxanthin lyserophosphate palmitate, astaxanthin lysephrophosphatidylcholine palmitate, astaxanthin lysephrophosphatidylcholine DHA, astaxanthin lysephrophosphatidylinositol palmitate, astaxanthin Fattidylinositol DHA, astaxanthing lyserophosphatidylinositol linoleic acid, astaxanthing lyserophosphatidylcholine linoleic acid, etc.), steviol glycosides, benzimidazole derivatives (1- (2-ethoxyethyl) -2- [1- (2 -(4- (1- (4,4-Dimethyl-2-oxazolin-2-yl) -1-methylethyl) phenyl) ethyl) piperidin-4-yl] -1H-benzimidazole, 2- [4 -(2- (4- (1- (2-ethoxyethyl) benzimidazol-2-yl) piperidin-1-yl) ethyl) phenyl] -2-methylpropanoic acid, ethyl 2- [4- (2- ( 4- (1- (2-ethoxyethyl) benzimidazol-2-yl) piperidin-1-yl) ethyl) phenyl] -2-methylpropanate, 1- (2-ethoxyethyl) -2- [1- ( 2- (4- (1,1-dimethyl-2-hydroxyethyl) phenyl) ethyl) piperidin-4-yl] -1H-benzimidazole, 1- (2-hydroxyethyl) -2- [1- (2- (4- (1- (4,4-Dimethyl-oxazolin-2-yl) -1-methylethyl) phenyl) ethyl) piperidin-4-yl] -1H-benzimidazole, 2- [4- (2- ( 4- (1- (2-hydroxyethyl) benzoimidazol-2-yl) piperidin-1-yl) ethyl) phenyl] -2-methylpropanoic acid), alanine derivatives or salts thereof (N- [3-isopentyl- 4-Methyl-2- [4- (3-trifluoromethylbenzamido) benzoylimino] -3H- Azoline-5-carbonyl] -L-alanine, N- [3-isopentyl-4-methyl-2- [4- (3-trifluoromethylbenzamido) benzoylimino] -3H-thiazoline-5-carbonyl] -2- Methylalanine, N- [3-isopentyl-4-methyl-2- [4- (3-trifluoromethylbenzamido) benzoylimino] -3H-thiazoline-5-carbonyl] -N-methyl-L-alanine, etc.) Thiazoline derivative or its salt (3-isopentyl-4-methyl-2- [4- (3-trifluoromethylbenzamido) benzoylimino] -3H-thiazoline-5-carboxylic acid, 4-isobutyl-3-methyl-2- [4- (3-trifluoromethylbenzamido) benzoylimino] -3H-thiazoline-5-carboxylic acid, etc.), chlorpheniramine maleate, diphenhydramine hydrochloride, diphenylpyraline hydrochloride, carbinoxamine maleate, hydrocortisone butyrate, sulfated acid mucos Polysaccharide or salt thereof Sulfated dextran or a salt thereof, fluoromethylhistidine or a hydrochloride thereof, histidine methyl ester or a hydrochloride thereof, licorice extract, sicon extract, age extract, propolis, eye (indigo leaf) extract, asenyaku (asen drug) extract, avocado extract, amadocoro (Bamboo bamboo) extract, Amiga lily extract, Baimo (shellfish mother) extract, Igakozorina (ground bile head) extract, Ibukitoranoo extract, Turmeric (Usu gold) extract, Echinashi (Hosobamurasakibarengiku) extract, Auren (Yoren) extract, Oguruma (turnover) extract, Hypericum persimmon (Brother cut grass) extract, Onigurumi extract, Orange extract, Cassia extract, Kamiyatsude (Tongweed) extract, Kawamidori extract, Kawara mugwort (Cotton chin) extract, Watercress extract, Kenashi Sartori Ibaraki , Gentian extract, co Ukisekoku extract, Kouhon (Kakimoto, Karamoto) extract, Koryokyo (Kora Kaki) extract, Gosho strawberry (covered bonsai) extract, Psycho-ran extract, Cherry extract, Salvia (sage) extract, Diquitaris extract, Linden extract, Salamander extract , Indobodai extract, Shukushamitsu (sand seed, shredded sand) extract, Juzudama extract, White minten (Nanten) extract, Ivy extract, Psyllium extract, Yarrow extract (Milfoil) extract, Shirohagenega extract, Takasago Gorhihitai Extract Shishitsuri extract, Hamasuge (Katsukishi) extract, Hishi (Rhijimi) extract, Bellows oyster extract, Pepper quail (South rattan) extract, Bundou (mung bean) extract, Sandalwood extract, Butcher bloom extract, Pansy extract, Hosoba aragiku (painful) Extract, Mizurutennansho (Tennansei) extract, pheasant (fruit) extract, miracle fruit extract, scented extract, peach (peach) extract, cornflower extract, willow willow extract, mistletoe (willow parasite) extract, Yabukouji (purple gold beef) extract, Artemisia extract, Artemisia (bamboo leaf) extract, Rosemary (Mannenrou) extract, Japanese tiger extract, Japanese jujumo extract, Tamajusumo

Extract, Mizojumo extract, Urushigusa extract, Loquat extract, Akamok extract, Togemoku extract, Aqaba extract, Maruba akaba extract, Harigane extract, Dulse extract, Yuna extract, Belladonna extract, Hoonoki extract, Harunie Extract, Aozuran extract, Sakaneran extract, Sababagin orchid extract, Chinese cabbage extract (including varieties and origins) extract, valerian extract, primrose extract, nematode extract, gypsum extract, honeysuckle extract, touki extract, fennel extract, peppermint extract, etc. Is mentioned.

(13) Anti-seborrheic agent An anti-seborrheic agent can be added to the cosmetic composition of the present invention. Specific examples of the antiseborrheic agent include chroman derivatives, pyridoxine or salts thereof and derivatives thereof, pyridoxal or salts thereof and derivatives thereof, pyridoxamine or salts thereof and derivatives thereof, sulfur, Asa extract, (Continuous) extract, Dutch mustard (watercress) extract, valerian extract (valerian root) extract, clematis extract, bear sebacekis, savonso extract, rosewood extract, horse chestnut extract, soybean (soybean) extract, Tokinsenka (marigold) extract, Chinese yam Examples include extract, yam extract, nosen-halen extract, dandelion poppy (sect winter flower, sect winter) extract, yabgarashi extract, giant kelp extract, hijirimen extract, primrose extract, haius banori extract.

(14) Antibacterial agent An antibacterial agent can be added to the cosmetic composition of the present invention. Specific examples of antibacterial agents include acrinol, sulfur, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or hydrolyzate thereof, alkyldiaminoethylglycine chloride solution, triclosan, sodium hypochlorite, chloramine T, salashi powder , Iodine compounds, iodoform, 1-alkylcarbapenem compounds, N-substituted azepane derivatives or salts thereof, sorbic acid or salts thereof, propionic acid or salts thereof, salicylic acid or salts thereof, dehydroacetic acid, parahydroxybenzoic acid esters, 2 -Keto-3-deoxyoctanoic acid fatty acid esters, inositol deoxy derivatives (such as quercitol), inositol unsaturated derivatives (such as chonditol), inositol dimethyl ether, methyl inositol, inositol methyl ester Ether, inosamine, deoxyinosadiamine, shikimic acid, quinic acid, undecylenic acid, thiamine lauryl sulfate, thiamine lauryl nitrate, phenol, cresol, p-chlorophenol, p-chloro-m-xylenol, p-chloro-m-cresol , Thymol, phenethyl alcohol, o-phenylphenol, irgasan CH3565, halocarban, hexachlorophene, chlorohexidine, ethanol, methanol, isopropyl alcohol, benzyl alcohol, propylene glycol, 2-phenoxyethanol, 1,2-pentanediol, zinc pyridione, Chlorobutanol, isopropylmethylphenol, elemol, vetiverol, patchouli alcohol, nonionic surfactant (polyoxyethylene lauryl ether, polyoxyethylene nonyl pheny Ether, polyoxyethylene octylphenyl ether, etc.), amphoteric surfactant, anionic surfactant (sodium lauryl sulfate, lauroyl sarcosine potassium, etc.), cationic surfactant (cetyltrimethylammonium bromide, benzalkonium chloride, benzethonium chloride, Methylrosaniline chloride), formaldehyde, hexamine, brilliant green, malachite green, crystal violet, germal, photosensitive element 101, photosensitive element 201, photosensitive element 401, N-long chain acyl basic amino acid derivatives and acid addition salts thereof, oxidation Zinc, hinokitiol, propolis, kudin extract, agi (Ayu) extract, asunaro extract, alpinia extract, katsudai (suzukuku) extract, Inubilu (Honagainubiu) extract, Aogatei extract, Haribiyueki , Ayuyu extract, Hagateto extract, Hosonagabiyu extract, Enmeiso extract, Warbler extract, Usubasaicin extract, Oshusaishin extract, Halibut extract, Ominae shrimp extract, Kajikazura , Kahoku salamander extract, chamomile extract, linden extract, red linden extract, yellow spider extract, caraway extract, betel extract, beetle extract, cranberry extract, grapefruit extract, celosia flower (chicken flower, chicken crown) extract, Bay bay extract, Koushinbara (monthly flower) extract, Copaiba balsam extract, Yamazakura extract, Edhigarashi extract, Miyaza cherry extract, Yoshino cherry extract, Kasami cherry extract, Kanza cherry extract, sugar beet extract, Sarashinashi Horse (Hemp) Extract, Sikunshi (Mikoshi) Extract, Birch Extract, Cinnamon Extract, Sorrel (Acid Model) Extract, Atlantic Dandelion Extract, Japanese Nezu (Etsumatsu) Extract, Japanese Pepper Extract, Wild Pepper Extract, Soka (Grass) Extract, onion extract, chicory extract, Korean senile (蕪 夷) extract, tsuruna (apricot) extract, tokon (root) extract, leek extract, leek extract, peach extract, patchouli extract, ganbanana (stone carp, (Ranju Shahua) extract, cypress extract, pimenta extract, Hirohakinagusa (bald bald eagle) extract, blackberry extract, hop extract, makuri (marine herb) extract, magnolia sprenger extract, Mizokakushi (half-sided lotus) extract, honey bee Extract, purple (purple) extract, moso bamboo extract, pokeweed (commercial land) extract, yukkae , Lobster extract, Lavender extract, Forsythia extract, Sylar forsythia extract, Prunus nomata extract, Tochaka (Yahazutsu no Mata) extract, Red-breasted extract, Anaanaosa extract, Human egusa extract, Hirohi-no-higusa extract, Ushito exosa extract, Irolo extract , Ishige extract, arame extract, tamamitadaki extract, tambanori extract, katanoori extract, cherry blossom extract, fujimatsumo extract, kawamozuku extract, aokawa mozuku extract, himeka mozuku extract, yakuchi (yachi) extract and the like.

(15) Blood flow promoter / vascular stimulator A blood flow promoter / vascular stimulator can be added to the cosmetic composition of the present invention. Specific examples of blood flow promoters / vascular stimulants include tocopherol or salts thereof and derivatives thereof, tocotrienol or salts thereof and derivatives thereof, cephalanthin, carpronium chloride, eugenol derivatives (acetyleugenol, methyleugenol, methylisoeugenol, ethyl (Eugenol, ethylisoeugenol, eugenol salicylate, etc.), minoxidil, chili pepper tincture, nonyl acid vanillamide, cantalis tincture, ginger tincture, peppermint oil, L-menthol, camphor, benzyl nicotinate, cinnarizine, trazoline, acetylcholine, verapamil, ectamol , Α-borneol, cyclandelate, nonyl acid wallenylamide, capsaicin, gingerone, assembly extract, garlic extract, carrot extract , Aloe extract, Gentian extract, Toki extract, Ashitaba (Tomorrow) extract, Arnica extract, Ukiyagara (Sanryo) extract, Himewiku extract, Citrus unshiu (Chest) extract, Toucan beetle (coconut) extract, Oyster extract, Persimmon extract, Kina extract, Goldfish hen extract, Anemone beetle extract, Gubijinsou extract, Kouhone (river bone) extract, Burdock (beef bowl, beef coconut) extract, Sagaki Kyo (Yamabachi) extract, Sinalengyo extract, Ginger extract, Shobu (bamboo shoot, radish) extract, Hawthorn extract, assembly (powdered medicinal) extract, Daidai (orange peel) extract, tanjin (dansang) extract, thyme extract, chiketsu carrot (bamboo ginseng) extract, tsurudokudami (what neck crab) extract , Carrot (tetralobium) extract, red pepper (banban) extract, toki (toll) , Japanese hornworm extract, Natsumikan extract, elderberry (bone-bone) extract, hazelnut (coconut) extract, Hashiridokoro (roth root) extract, mint (light load, light load) extract, Hamabou Fu (hama wind) extract, Higotai extract , Fujimodoki (Chojizakura, Camellia) extract, Black currant extract, Bodaiju (Aoki tree) extract, Merirot extract, Yuzu extract, Loquat extract, Japanese jelly extract, Hibiscus extract, Rosehip extract and the like.

(16) Antiandrogen Agent An antiandrogen agent can be added to the cosmetic composition of the present invention. Specific examples of antiandrogens include follicular hormones (estrone, estradiol, ethinyl estradiol, etc.), isoflavones, oxendrone, 4 ′, 5,7-trihydroxy-8-prenylflavanone, 4 ′, 5,7-trihydroxy-8 -Prenyl flavone, 3,3 ′, 4 ′, 5,7-pentahydroxy-8-prenyl flavone, nicorandil, cyclosporine and the like.

(17) Inhibitors of structural proteolytic enzymes (elastase, collagenase, keratin protease, serine protease, integrin degrading enzyme, involucrin degrading enzyme, filaggrin degrading enzyme, laminin degrading enzyme, fibronectin degrading enzyme, proteoglycan degrading enzyme, etc.) / Structural proteolytic enzyme expression inhibitor The cosmetic composition of the present invention contains structural proteolytic enzymes (elastase, collagenase, keratin protease, serine protease, integrin degrading enzyme, involucrin degrading enzyme, filaggrin degrading enzyme, laminin degrading enzyme, fibronectin degrading enzyme) Matrix metalloproteinases such as enzymes and proteoglycan degrading enzymes) activity inhibitors / structural protease inhibitors can be added. Specific examples of structural protease inhibitors / structural protease inhibitors include adenine derivatives (butanetriol-9-adenine and its phosphate adduct, propanediol-9-adenine and its phosphate adduct, Pentanetriol-9-adenine and its phosphate adducts), carbostyril derivatives or salts thereof, dicarboxylic acids (glutaric acid, adipic acid, pimelic acid, suberic acid, azelaic acid, sebacic acid, 1,9-nonamethylenedicarboxylic acid) Acid, 1,10-decamethylenedicarboxylic acid), rosmarinic acid, ursolic acid, oleanolic acid, hydroxamic acid derivative, esculetin derivative, anthocyanidins, nordihydroguaiaretech acid, 20-carboxy-16-hydroxy-21-nor- 5 α-7,9 (11) -lanostadien-3,24-dione, ubiquinone, plastaquinone, yugro , Shikonin, quinizarin, alizarin, abietin, levopimaric acid, betulin, α-amylin, catechin compounds (catechin, epigallocatechin, epigallocatechin gallate, epicatechin, epicatechin gallate, catechin rhamnopyranoside catechin, etc.), fluoro Diisopropyl phosphate, (2R, 6R) -2,6-dihydroxy-4- (tert-butyldimethylsilyloxy)-(3Z) -heptene-1,7-dicarboxylate, N, N'-bis-[( 1S, 2R) -2-hydroxyindan-1-yl]-(2R, 6R) -2,6-dibenzyloxy-4-hydroxyheptanedicarboxylic acid-1,7-diamide, (2R, 6R) -2, 6-dihydroxy-4- (tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylate, (2R, 6R) -2,6-dibenzyloxy-4- (tert-butyldimethylsilyloxy) heptane- Dimethyl 1,7-dicarboxylate, (2R, 6R) -2,6-dibenzyloxy-4- (tert-butyl Tyldimethylsilyloxy) heptane-1,7-dicarboxylic acid, N, N'-bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2R, 6R) -2,6-dibenzyloxy -4- (tert-butyldimethylsilyl) oxyheptane-1,7-dicarboxylic acid diamide, N, N'-bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2R, 6R)- 2,6-dibenzyloxy-4-hydroxyheptane-1,7-dicarboxylic acid diamide, N, N'-bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2R, 6R)- 2,4,6-Trihydroxyheptane-1,7-dicarboxylic acid diamide, N, N'-bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2S, 6S) -2,6 -Dibenzyloxy-4-hydroxyheptane-1,7-dicarboxylic acid diamide, (2S, 6S) -2,6-dihydroxy-4- (tert-butyldimethylsilyloxy)-(3Z) -heptene-1,7 Dimethyl dicarboxylate, dimethyl (2S, 6S) -2,6-dihydroxy-4- (tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylate (2S, 6S) -2,6-dibenzyloxy-4- (tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylate, (2S, 6S) -2,6-dibenzyloxy- 4- (tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylic acid, N, N′-bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2S, 6S) -2, 6-Dibenzyloxy-4- (tert-butyldimethylsilyl) oxyheptane-1,7-dicarboxylic acid diamide, N, N′-bis [(1S, 2R) -2-hydroxyindan-1-yl]-( 2R, 6R) -2,6-Dibenzyloxy-4-hydroxyheptane-1,7-dicarboxylic acid diamide, 3-[[4- (4-fluorophenoxy) -benzenesulfonyl]-(1-hydroxycarbamoylcyclopentyl) -Amino] -propionic acid, 4- [4- (4-fluorophenoxy) -benzenesulfonylamino] -tetrahydropyran-4-carboxylic acid hydroxyamide, 4- [4- (4-chlorophenoxy) -benzenesulfonylmethyl] -Tetrahydropyran-4-carboxylic acid hydroxyamide, 3-[[4- (4-fluorophenoxy) -benzenesulfonyl]-(1-hydroxycarbamoylcyclobutyl) -amino] -propionic acid, 4- (4'-chloro Biphenyl-4-yl) -2- [2- (1,3-dioxo-1,3-dihydroisoindol-2-yl) -ethyl] -4-oxobutyric acid, 1- [4- (4-fluorobenzyl) Oxy) -benzenesulfonyl] -2-hydroxycarbamoylpiperidin-3-yl) -carbamic acid isopropyl ester, 2- [4- (4-fluorophenoxy) -benzenesulfonylamino] -N-hydroxy-2-methylpropionamide, 3- [4- (4-Fluorophenoxy) -benzenesulfonyl] -2, N-dihydroxypropionamide, 3- (4-phenoxybenzenesulfonyl) -7-oxabicyclo [2.2.1] heptane-2-carboxylic acid hydroxy Amide, (4-benzylbenzyl)-[2- (2,2-dimethyl-1-methyl Rubamoylpropylcarbamoyl) -4- (4'-fluorobiphenyl-4-yl) -butyl] -phosphinic acid, 2-amino-3- [4- (4-fluorophenoxy) -benzenesulfonyl] -N-hydroxypropion Amide, N-Hydroxy-2- (4-phenylpiperidine-1-sulfonyl) -acetamide, Iris japonicus extract, Nepenthes (Summer hay) extract, Greater Crape myrtle (Banaba) extract, Large hawthorn extract, Hawthorn (Yamako) extract, Calahoo (Park) extract, guava extract, trash (Gomiko) extract, papaver extract, rose rose extract, Hypericum perforatum extract, chickweed extract , American Grape Extract, European Grape Extract, Yama Grape Extract, Mandarin Extract, Mishima Psycho (Shibahu) Extract, Ou Gon extract, Hypericum extract, Clara extract, Mulberry extract, Keihi extract, Gentian extract, Comfrey extract, Salvia extract, Elderberry extract, Body squirrel extract, Button pi extract, Aos zulan extract, Sakaneran extract, Sasabagin orchid extract, Chinese cabbage extract (variety and origin) (Including seeds) extract, red-green agave extract, sisal extract, garlic extract, and the like.

(18) Structural protein synthesis promoter A structural protein synthesis promoter can be added to the cosmetic composition of the present invention. Specific examples of structural protein synthesis promoters include ethanolamine derivatives, pentoxyphyllin, serine derivatives, geraniol, crocetin, methyl 4- (2-ethylhexyloxy) -2-hydroxybenzoate, 2-hydroxy-4- (3, 5,5-Trimethylhexyloxy) methyl benzoate, methyl 4-cyclohexylmethoxy-2-hydroxybenzoate, methyl 4- (2-cyclohexylethoxy) -2-hydroxybenzoate, 4- (3,7-dimethyl-6 -Octenyloxy) methyl 2-hydroxybenzoate, ethyl 3- (2-ethylhexyloxy) -5-hydroxybenzoate, methyl 5- (2-ethylhexyloxy) -2-hydroxybenzoate, 2-hydroxy-5 -(3,5,5-trimethylhexyloxy) methyl benzoate, methyl 5- (2-cyclohexylethoxy) -2-hydroxybenzoate, methyl 4-N-hexyloxy-2-hydroxybenzoate, 2-hydride Methyl xyl-4-N-octyloxybenzoate, methyl 4-N-decyloxy-2-hydroxybenzoate, methyl 5-N-hexyloxy-2-hydroxybenzoate, 4- (2-ethylhexyloxy) -2- Hydroxybenzoic acid, 2-hydroxy-4- (2,5,5-trimethylhexyloxy) benzoic acid, 4-cyclohexylmethoxy-2-hydroxybenzoic acid, 4- (2-cyclohexylethoxy) -2-hydroxybenzoic acid, 4- (3,7-dimethyl-6-octenyloxy) -2-hydroxybenzoic acid, 3- (2-ethylhexyloxy) -5-hydroxybenzoic acid, 5- (2-ethylhexyloxy) -2-hydroxybenzoic acid Acid, 5- (2-ethylhexyloxy) -2-hydroxybenzoic acid, 2-hydroxy-5- (3,5,5-trimethylhexyloxy) benzoic acid, 5- (2-cyclohexylethoxy) -2-hydroxybenzoic acid Acid, 4-N-hexyloxy-2-hydroxybenzoic acid, 5-N-hexyloxy-2 -Hydroxybenzoic acid, 2-hydroxy-4-N-octyloxybenzoic acid, 4-N-decyloxy-2-hydroxybenzoic acid, N- (2-hydroxyethyl) -4- (2-ethylhexyloxy) -2- Hydroxybenzamide, N-ethyl-4- (2-ethylhexyloxy) -2-hydroxybenzamide, 2-acetoxy-4-cyclohexylmethoxybenzoic acid, 4- (2-ethylhexyloxy) -2-hydroxybenzoic acid sodium, 4- [(2E) -3,7-dimethyl-2,6-octadienyloxy] -2-hydroxybenzoate methyl, 4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] Ethyl-2-hydroxybenzoate, 5-[(2E) -3,7 dimethyl-2,6-octadienyloxy] -2-hydroxyethyl benzoate, 3-[(2E) -3,7-dimethyl- Ethyl 2,6-octadienyloxy] -2-hydroxybenzoate, ethyl 3-[(2E) -3,7-dimethyl-2,6-octadienyloxy] -5-hydroxybenzoate, 4- [(2E) -3,7-dimethyl-2,6-octadienyloxy] -3-methoxybenzoate, 4-[(2E, 6E) -3,7,11-trimethyl-2,6,10 -Dodecatrienyloxy] -2-hydroxybenzoic acid methyl, 4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] -2-hydroxybenzoic acid (2E) -3,7- Dimethyl-2,6-octadienyl, 4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] -2-hydroxybenzoic acid, 5-[(2E) -3,7-dimethyl- 2,6-octadienyloxy] -2-hydroxybenzoic acid, 3-[(2E) -3,7-dimethyl-2,6-octadienyloxy] -2-hydroxybenzoic acid, 3-[(2E ) -3,7-dimethyl-2,6-octadienyloxy] -5-hydroxybenzoic acid, 2-hydroxy-4-[(2E, 6E) -3,7,11-trimethyl-2,6,10 -Dodecatrienyloxy] benzoic acid, 4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] -3-methoxybenzoic acid, 2-acetoxy-4-[(2E) -3 , 7-Dimethyl-2,6-octadienyloxy ] Benzoic acid, N- (2-hydroxyethyl) -4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] -2-hydroxybenzamide, 4-[(2E) -3, 7-dimethyl-2,6-octadienylamino] -2-hydroxybenzoic acid, dimethyl-2,6-octadienyloxybenzoic acid, N- (2-hydroxyethyl) -4-[(2E) -3 , 7-dimethyl-2,6-octadienyloxy] -2-hydroxybenzamide, 4-[(2E) -3,7-dimethyl-2,6-octadienylamino] -2-hydroxybenzoic acid, 3 -Dodecyloxybenzoic acid, 3- (12-hydroxydodecyloxy) benzoic acid, 4-dodecyloxybenzoic acid, 4- (12-hydroxydodecyloxy) benzoic acid, 3- (12-hydroxyoctadecyloxy) benzoic acid, 4 -(12-hydroxyoctadecyloxy) benzoic acid, 3- (11-hydroxyundecyloxy) benzoic acid, 4- (11-hydroxyundecyloxy) benzoic acid, 3-[(2E) -3,7-dimethyl- 2,6- Tadienyloxy] benzoic acid, 4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] benzoic acid, 3-[(2E, 6E) -3,7,11-trimethyl-2,6 , 10-dodecatrienyloxy] benzoic acid, 4-[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] benzoic acid, 4- [3,7-dimethyl -9- (2,6,6-trimethyl-1-cyclohexen-1-yl) -2,4,6,8-nonatetraenyloxy] benzoic acid, 4- [3,4-dihydro-2,5, 7,8-Tetramethyl-2- (4,8,12-trimethyltridecyl) -2H-1-benzopyran-6-oxy] benzoic acid, 4-[(2E, 6E) -3,7,11-trimethyl -2,6,10-dodecatrienyloxy] benzamide, 4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] benzamide, 4- (2-methyl-2-butenyloxy) benzamide 4- (2-ethylhexyloxy) benzamide, 4-dodecyloxybenzamide, 4- (12-hydroxydodecyloxy) benzamide, 4- (12-hydroxyoxy) Tadecyloxy) benzamide, 4- (11-hydroxyundecyloxy) benzamide, 4- (10-hydroxydecyloxy) benzamide, 4-isostearyloxybenzamide, N- (2-hydroxyethyl) -4-[(2E, 6E ) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] benzamide, N, N-dimethyl-4-[(2E, 6E) -3,7,11-trimethyl-2,6, 10-dodecatrienyloxy] benzamide, N, N-di [(2E) -3,7-dimethyl-2,6-octadienyl] -4-aminobenzamide, 4- [N'-methoxycarbonyl-N-[( 2E) -3,7-dimethyl-2,6-octadienylamino] benzamide, 4- [N-acetyl-N-[(2E) -3,7-dimethyl-2,6-octadienyl]] aminobenzamide, N- (2-hydroxyethyl) -4-[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] -2-hydroxybenzamide, N, N-diethyl-4 -[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyl Xy] -2-hydroxybenzamide, pea extract, red pepper extract, scots reed extract, hosobonori extract, bonito extract, igisu extract, keigi extract, harii squirrel extract, honey beet extract, euglena extract, moly rush extract, Willow extract, Willow extract, Motsuyurena extract, Venetian extract, Moth willow extract, Sabaya willow extract, Wasabi extract, Merbow extract and the like.

(19) Mucopolysaccharide (hyaluronic acid, chondroitin sulfate, etc.) degrading enzyme inhibitor A mucopolysaccharide (hyaluronic acid, chondroitin sulfate, etc.) degrading enzyme inhibitor can be added to the cosmetic composition of the present invention. Specific examples of mucopolysaccharide (hyaluronic acid, chondroitin sulfate, etc.) degrading enzyme inhibitors include anacardic acid or its derivatives (6-pentadecatrienylsalicylic acid methyl ether, 6-pentadecatrienylsalicylic acid ethyl ether, 6-pentadecaic acid). Trienyl salicylic acid propyl ether, 6-pentadecatrienyl salicylic acid butyl ether, 6-pentadecatrienyl salicyl alcohol methyl ether, 6-pentadecatrienyl salicyl alcohol ethyl ether, 6-pentadecatrienyl salicyl alcohol propyl ether, 6- Pentadecatrienyl salicyl alcohol butyl ether, 6-pentadecatrienyl salicylaldehyde methyl ether, 6-pentadecatrienyl salicylaldehyde ethyl ether, 6-pentadecatrienyl salicylaldehyde Propyl ether, 6-pentadecatrienyl salicylaldehyde butyl ether, 2-methyl ether-6-pentadecatrienyl cinnamic acid, 2-ethyl ether-6-pentadecatrienyl cinnamic acid, 2-propyl ether-6- Pentadecatrienyl cinnamate, 2-butyl ether-6-pentadecatrienyl cinnamate, 2-methyl ether-6-pentadecatrienyl cinnamate alcohol, 2-ethyl ether-6-pentadecatrienyl cinnamate Alcohol, 2-propyl ether-6-pentadecatrienyl cinnamic alcohol, 2-butyl ether-6-pentadecatrienyl] cinnamic alcohol, etc.), polyisoprenylated benzophenone derivatives (garcinol, isogarcinol, xanthothymol) , Isoxanthothymol, gucciferon, etc.), licorice extract (October) extract, Narco lily extract, Occidental lily (Yellow spirit) extract, Oregano extract, Oshida extract, Onji extract, Spruce extract, Crow birch extract (half-summer) extract, Pheasant extract Skin) extract, goshyu extract, senega extract, sendan extract, tamarind extract, tarragon extract, ginkgo biloba extract, bee extract, daisy extract, mirabaran extract, himebara extract, Mockin Extract, Laurel Extract, Yabusotatsu Extract, Anaaaosa Extract, Macrocystis Integrifolia Extract, Neocitus Ruetkeana Extract, Nettle Extract, Prunus Extract, Kata-Bucka Extract, Yatabegusa Extract, Shimatengusa Extract, Ezotsunomata Kisses, Swallowtail extract, Fusiwa ivy extract, Hanemo extract, Mill extract, Chromel extract, Nagamil extract, Hiramil extract, Matsumo extract, Okinawa mozuku extract, Mozuku extract, Fukuronori extract, Kajime extract, Orochi nori extract, Mafnori extract, Grape leaf extract, Salamander extract, Astragalus extract etc. are mentioned.

(20) Mucopolysaccharide synthesis promoter A mucopolysaccharide synthesis promoter can be added to the cosmetic composition of the present invention. Specific examples of the mucopolysaccharide synthesis accelerator include stilbene derivatives or salts thereof, morgin or salts thereof and derivatives thereof, N-acetylglucosamine, flax extract, cinnamon extract, mulberry extract, scotch extract, breadfruit extract, hirakotoji extract , Kotojitsu no Mata Extract, Yaleus Banori Extract, Kagiosu Banori Extract, Susius Banori Extract, Amiaosa Extract, Nagaaosa Extract, Hosobanosakamodoki Extract, Hirohatosakamodoki Extract, Yatsudegatatosakamodoki Extract, Kurotosakamodoki Examples include extract, Nezushinosakamodoki extract, Yusora extract, Etsukinotosakamodoki extract, Nankaitosakamodoki extract, Himetosakamodoki extract, and the like.

(21) Intercellular lipid production promoter / intercellular lipid state improver An intercellular lipid production promoter / intercellular lipid state improver can be added to the cosmetic composition of the present invention. Specific examples of intercellular adipogenesis promoters / intercellular lipid state improvers include phospholipids (phosphatidylethanol, phosphatidylcholine, phosphatidyltriethanolamine, phosphatidylserine, phosphatidic acid, phosphatidylglycerin, phosphatidylinositol, diacylphosphatidylcholine, diacylphosphatidylethanol Amine, diacylphosphatidylinositol, diacylphosphatidylserine, 1-cysteinylphosphatidic acid, 2-cysteinylphosphatidic acid, 1-glutathionylphosphatidic acid, 2-glutathionylphosphatidic acid, 1-azelaoylphosphatidic acid, 2- Azela oil phosphatidic acid, 1-hydroxyacyl phosphatidic acid, 2-hydroxyacyl phosphatidic acid, ceramide, glucosyl Lamide, galactosylceramide, cerebroside, phosphatidylglucosylacylglycerol, N-oleoylsphingosine, N- (12-hydroxyoctadecanoyl) sphingosine, N- (16-hydroxyhexadecanoyl) sphingosine, N-salicyloylphytosphingosine, Sphingomyelin, soybean lecithin, egg yolk lecithin, etc.), sterins (cholesterol, dihydrocholesterol, cholesteryl stearate, cholesteryl hydroxystearate, macadamia nut oil fatty acid cholesteryl, β-sitosterol, stigmasterol, campesterol, ergosterol, 5-dihydro Ergosterol, phytosterol, 25-hydroxycholesterol, 26-hydroxycholesterol, 19-hydroxycholesterol, 22-ketocholes Roll oxime, 6-ketocholesterol and 7-ketocholesterol or their derivatives), N-acetylneuraminic acid (sialic acid), N-glucosolneuraminic acid, gangliosides (gangliotriose, gangliotetraose , Globotetraose, neolactotetraose, neolactohexaose, neolactooctaose, etc.), oligosulfated hyaluronic acid, hydroxytamoxifen compounds, glyceroglycolipids, pentoxyphyllin, 3-deazaadenosine, carboxamide derivatives, Inositol polyamines, sialic acid, triterpenic acid derivatives, lactose, lactosamine derivatives, sulfated chitin derivatives, albumin, ginseng extract, tochiban ginseng extract, sea cucumber extract, red lily extract, green lily extract, chickweed extract And the like.

(22) Keratin solubilizing agent / horny layer peeling accelerator A keratolytic agent / horny layer peeling accelerator can be added to the cosmetic composition of the present invention. Specific examples of keratolytic agents / stratum exfoliation accelerators include tropolone and its derivatives, resorcin, lactic acid, urea, salicylic acid, guanidine, ethanolamine, kikarasuuri (Gurone) extract, fenugreek extract, wisteria bean extract, lentil extract Chickpea extract, mungbean extract and the like.

(23) Plasminogen activator antagonist inhibitor A plasminogen activator antagonist inhibitor can be added to the cosmetic composition of the present invention. Specific examples of the plasminogen activator antagonist inhibitor include rabbit daisy extract, canamgra extract, caladium extract, raspberry extract and the like.

(24) Maillard reaction inhibitor A Maillard reaction inhibitor can be added to the cosmetic composition of the present invention. Specific examples of Maillard reaction inhibitors include aminoguanidine, flavanones (naringin, naringenin, liquiritin, liquiritigenin, digallic acid, luteoic acid, ellagic acid, chlorogenic acid, glucogallin, tetralin, hamamelitannin, gallic tannin, tannic acid, (Geraniin, gallic acid, galloyl gallic acid, ellagitannin, hexagalloyl glucose, heptagalloyl glucose, tetragalloyl glucose, triggerroyl glucose, pentagalloyl glucose, digalloyl quinic acid, triggerroyl quinic acid), 2-hydroxyphenylalkylamine Derivatives or salts thereof, phenylpropenoic acid derivatives (3- [2,3-bis (methoxymethoxy) phenyl] propenoic acid, 7- (4-hydroxy-3-methoxyphenyl) hepta-2,4,6-trienoic acid, 3- (3,5-Dimethoxy-4-hydroxy (Roxyphenyl) propenohydrazide, N'-isopropylidene-3- (2-methoxyphenyl) propenohydrazide, etc.), citric acid or its salts, gypsum extract, sandalwood extract, red clover extract, persimmon (柿) (Including moths) Examples include Tarayo extract, Dokudami extract, Tormentilla extract, Bakumondo extract, Hiba extract, Grape extract, Japanese willow extract, Mukuroji extract, Karin extract, Mokka extract, Roman chamomile extract and the like.

(25) Testosterone 5α reductase activity inhibitor / hair papilla activator / hair growth promoter A testosterone 5α reductase activity inhibitor / hair papilla activator / hair growth promoter is added to the cosmetic composition of the present invention. Can do. Specific examples of testosterone 5α reductase activity inhibitor / hair papilla activator / hair growth promoter include γ-amino-β-hydroxybutyric acid esters (γ-amino-β-hydroxybutyric acid methyl ester, γ-amino-β- Hydroxybutyric acid ethyl ester, γ-amino-β-hydroxybutyric acid propyl ester, γ-amino-β-hydroxybutyric acid butyl ester, γ-amino-β-hydroxybutyric acid ethylhexyl ester, γ-amino-β-hydroxybutyric acid hexadecyl ester, γ-amino-β-hydroxybutyric acid lauryl ester, γ-amino-β-hydroxybutyric acid stearyl ester, γ-amino-β-hydroxybutyric acid oleyl ester, γ-amino-β-hydroxybutyric acid benzyl ester, γ-amino-β- Hydroxybutyric acid phenyl ester, γ-amino-β-hydroxybutyric acid ethyl glycol ester, γ-amino-β-hydroxy Acid sorbitol ester, γ-amino-β-hydroxybutyric acid polyoxyethylene glycol ester, γ-amino-β-hydroxybutyric acid glycerin ester, etc.), amine oxides (oleyl dimethylamine oxide, stearyl dimethylamine oxide, palmityl dimethylamine oxide) , Myristyl dimethylamine oxide, lauryl dimethylamine oxide, dimethyl lauryl ethoxyamine oxide, dihydroxyethyl lauryl amine oxide, coconut oil alkyl dimethylamine oxide, etc.), alkyl betaines (coconut oil fatty acid amidopropyl betaine, coconut oil alkyl betaine, lauryl dimethyl) Aminoacetic acid betaine, lauric acid amidopropyl betaine, lauryl hydroxysulfobetaine, 2-alkyl-N-carboxymethyl-N-hydroxyethyl Imidazolinium betaine), pyrimidine-N-oxide derivatives (2-amino-4-methyl-6-piperidinopyrimidine-3-oxide, 2-amino-4-methyl-6- (1-pyrrolidinyl) pyrimidine- 3-oxide, 2-amino-4-methyl-6-morpholinopyrimidine-3-oxide, 2-amino-4-methyl-6- [1- (4-methylpiperazinyl)] pyrimidine-3-oxide, 2-amino-4- (1-hexahydroazepinyl) -6-methylpyrimidine-1-oxide, 2-amino-4-dimethylamino-6-methylpyrimidine-1-oxide, 2-amino-4-allylamino -6-methylpyrimidine-1-oxide, 2-amino-4-benzylamino-6-methylpyrimidine-1-oxide, 2-amino-4,5-methyl-6-piperidinopyrimidine-3-oxide, 2 -Amino-4-ethyl-6-morpholinopyrimidine-3-oxide, 2-amino-4-methyl-5-nitro-6-piperidinopyrimidine-3-oxide, 2,5-diamino- 4-methyl-6-piperidinopyrimidine-3-oxide, 2-amino-4-methyl-5,6-bis (1-pyrrolidinyl) pyrimidine-3-oxide, 2-amino-4-methyl-5-piperidino -6- (1-pyrrolidinyl) pyrimidine-3-oxide, 2-methyl-4-amino-6-piperidinopyrimidine-3-oxide, 2-methyl-4-amino-5-bromo-6- (1- Pyrrolidinyl) pyrimidine-3-oxide, 2-methyl-4-amino-5-nitro-6-piperidinopyrimidine-3-oxide, 2-methyl-4,5-diamino-6-piperidinopyrimidine-3- Oxide, 2-methyl-4-amino-5,6-bis (1-pyrrolidinyl) pyrimidine-3-oxide, 2-amino-4-methyl-6-piperidinopyrimidine-3-oxide monohydrochloride, 2- Acetylamino-4-methyl-6-piperidinopyrimidine-3-oxide, 2,4-diamino-6-phenoxypyrimidine-3-oxide, 2,4-diamino-6- (2,4-dichlorophenoxy) pyrimidine -3-oxide, 2,4- Amino-6- (2,4,6-trichlorophenoxy) pyrimidine-3-oxide, 2,4-diamino-5-nitroso-6- (2,4-dichlorophenoxy) pyrimidine-3-oxide, 2,4- Diamino-5-nitro-6- (2,4,6-trichlorophenoxy) pyrimidine-3-oxide, 2,4-diamino-5-nitro-6- (2,4-dichlorophenoxy) pyrimidine-3-oxide, 2,4,5-triamino-6- (2,4-dichlorophenoxy) pyrimidine-3-oxide, 2,4-diamino-5-bromo-6- (2,4-dichlorophenoxy) pyrimidine-3-oxide, etc. ), P-menthane-3,8-diol, monoglyceryl-D-glucoside monotridecanoate, 1-oN-pentadecylglycero-D-glucoside, monopentadecanoic acid glyceride sulfate, etc. -Monopentadecyl glyceryl ether sulfate, 1-o-hexadecyl-2-o-methylglycerin, 1-o-octadecyl-2-o-me Luglycerin, 1-o-oleyl-2-o-methylglycerin, acetylcarnitine or its salt, geranylgeranylacetone, hydroxamic acid derivative or its salt, gingerone glycoside, benzeneoxyacetic acid derivative ([5- [2- [1 -Phenyl-1- (3-pyridyl) methylideneaminooxy] ethyl] -7,8-dihydronaphthalen-1-yloxy] acetic acid), isorhamnetin-3-robinobioside, xanthone derivatives, proanthocyanidins (grape seed extract) Proanthocyanidins, apple-derived proanthocyanidins, pine-derived proanthocyanidins, purified procyanidin oligomers, procyanidin B-1, procyanidin B-2, procyanidin B-3, procyanidin C-1), aracaci extract, angelica extract, apricot extract , Hong anzu extract, Ichiyakuso (one herb) extract, Enishiidae Kiss, Psyllium (carrot, carp grass) extract, Psyllium shabushi extract, olive extract, giant pufferfish extract, seisei extract, calla cucumber extract, Chinese pear extract Camphor extract, kubeba extract, buckthorn extract, potato oyster extract, snapdragon extract, snapdragon extract, kippi extract, beetle extract, cilantro extract, kobushi extract, magnolia extract Extract, Consulango extract, Sasanqua extract, Sweet potato extract, Sunabune jujube (acid soy sauce) extract, Sandscon (Yamazu root) extract, Potato extract, Shishigashira Kiss, Sanshishi extract, Coriander extract, Stevia extract, Takatodai extract (Otsuchi) extract, Tarayo (Ooba Fuyu Ao, Ichiha tea, Bitcho tea, Tofu tea) extract, Taranoki extract, Nigaki (Nakiki) extract, Nurde (pentose) extract , Hakamauraboshi (bone crushing) extract, spider magnolia extract, scented squirrel extract, stag beetle extract, scallop extract, citron carrot (participant) extract, mangosteen extract, myoga extract, melaleuca extract, yashabushi extract, himeya chabushi extract , Abalone chabushi extract, yakumoso extract, yamahanoki (yamabeki) extract, longan (longan) meat extract, locon (yoshi, sone) extract, logwood extract, lantana extract and the like.

(26) Hair matrix cell growth inhibitor / hair growth inhibitor A hair matrix growth inhibitor / hair growth inhibitor can be added to the cosmetic composition of the present invention. Specific examples of hair matrix cell growth inhibitor / hair growth inhibitor include phthalazinones, benzoxazinones, phosphonic acid derivatives, cyproterone, 5α-androstene-3α, 17β-diol, medroxyprogesterone, norethisterone, methanolone, ichihatsu (First) extract, citrus extract, kanto extract, sanjiko extract, silamo extract, sardine extract, scabbard fern extract, fritillary extract, honeysuckle extract, seaweed extract, oleander extract and the like.

(27) Hair swelling agent / hair protecting agent A hair swelling agent / hair protecting agent can be added to the cosmetic composition of the present invention. Specific examples of the hair swelling agent / hair protecting agent include ethanolamine, urea, guanidine, silicones, blueberry extract, mango extract and the like.

(28) Odorous substance erasing agent An odorous substance erasing agent can be added to the cosmetic composition of the present invention. Specific examples of the odorous substance eliminating agent include Inondo extract, Elemi extract, vanilla bins extract, pine extract and the like.

5. Ingredients used as additives Specific examples of ingredients derived from plant-based materials used as additives in the cosmetic composition of the present invention include Aokazura (Seifuto) extract, Aotenma extract, Akasuguri extract, Akinire (crust) extract , Aguay guassu extract, abiu extract, abiurana extract, yellow sapote extract, ylang ylang extract, phalaenopsis extract, uba tea extract, squirrel orchid extract, elmberry extract, elderberry extract, sasayuki extract, sasanoyuki extract, tossed cactus extract , Omia catechu extract, Onoelan extract, Crab extract (Kinshato) extract, Karaya extract, Garyu extract, Kawaratake extract, Candelilla extract, Canna extract, Kidachi pepper extract, Kimenkaku extract, Cave extract, Kiraja saponariae , Ginsakai extract, Kimbusen extract, Guapeba vermelha extract, Kugenumaran extract, Gooseberry extract, Curitiba extract, Curkurigo latifolia extract, Black moth (rescue) extract, Cucumber extract, Sapotea mariyo extract, Salmon berry extract , Salamander Extract, Sancactus Cactus Extract, Sancyou Sou Extract, Shunran Extract, Shozukku Extract, Shirubanatsuta Extract, Cinchona Silla Silva Extract, Swimberry Extract, Star Apple Extract, Sulgaran (Oran) Extract, Scots Pine Extract, Seiyo Cypress extract, scallop extract, mistletoe extract, sennin cactus extract, senboku extract, elephant biloba extract, cinnamon extract, somomemo Potato extract, dark sweet cherry extract, red pear extract, choco nostay extract, ginkgo biloba extract, tsukushi kaneran extract, tsuchiakebi extract, duckweed extract, duberry extract, red lizard extract, tragacanth extract, triacan Sos extract, Neiseria berry extract, Rapeseed extract, Plover-dough extract, Pau-dose extract, Hakuru berry extract, Batata extract, Hamakakiran extract, Balata extract, Harcan orchid extract, Pecan nut extract, Chicknut extract , Brazilian carrot extract, Bragenen extract, Frucereria extract, Blond psyllium extract, Hetsukaran extract, Heneken extract, Berry extract, Persea extract, Pervianburg extract, Pereschia Grandifolia extract, Boysenberry extract, Hosairan extract, Pouteria zapota extract, Pouteria rukuma extract, Hosobabarengiku extract, White berry extract, Masaransuba extract, Masheila de Boyi extract, Matta auryo extract, Mulberry extract , Green sapote extract, purple corn extract, megacansa opuntica extract, mokukirin extract, maple leaf extract, morero cherry extract, yakawa potato extract, cornflower mint extract, rulitama thistle (urajiro higotai) extract, red currant extract, Examples include plant extracts such as red pitaya extract, lemongrass extract, wax palm extract and logan berry extract.

  In addition, as specific examples of components derived from plant-based materials used as an additive of the cosmetic composition of the present invention, Dunaliella genus Dunaliella extract, Kuwanomi genus Kuwanomimo extract, Volbox genus genus sunflower extract, Volbox genus Volbox extract, Palmera extract, Jupiter extract, Aomydra spp. Titanium extract, Pseudomonas spp., Casanori prunus extract, Mika Kaki extract, Collecaete extract, Tsubomi prunus extract, Pseudomonas genus extract, Sayamidro extract, Kun Green algae extract such as spruce extract, Sumiremo violet reed extract, Hosimidro extract, Fuchinashimidoro extract , Isogawala genus Isogawara extract, Black moth genus Black moth moth extract, Kashirazaki genus Kashirazaki essence, Muchimo genus Muchimo extract, Muchimo genus Hiramachimo extract, Muchimo genus Quercus crisposa extract, Amygusa genus Sakibiro amiji extract, Common genus genus Common genus extract, Jigamigusa genus digigagus Nami-makura genus Hirami-makura extract, Someraceae genus Someraceae extract, Navaimo genus Navarimo extract, Chasommen genus Mochachasomen , Nagamatsu spp. , Crested genus Crested genus Extract, Crested genus Crested genus Extract, Common crested genus Common crested extract, Common crested genus Baccharum extract, Cultivated crested genus Extract Yokojimanori Extract, Cyprus genus Cyprus extract, Fritillaria genus extract, Crane vine extract, Cageridae chrome extract , Chrysanthemum genus Chrysanthemum genus extract, Spider genus Spider extract, Brown algae extract such as Burdrum genus Burukimo extract, Amanori genus Uprinori extract, Amanori spp. Genus Milnobeni extract, Konahada hykonahada extract, Konahada yogore nahada extract, Konahada aokonahada extract, Cyprinus genus Tsukumonori extract, Cyprinus genus Camellia spp. , Sodegarami Sodegarami Extract, Hirohatamitaki Hirohatamitaki Extract, Tengusa Nambugusa Extract, Tengusa Kohira Extract, Tengusa Yohira Extract, Tengusa Extract Licorice extract, Hibiro spruce extract, Hibiro spp. , Okitsubara Okibutsubara Extract, Sangomoda Ragarodoku Extract, Shiogusagoromo Shiogusagoromo Extract, Iwanokawa Etsukiiwakawa Extract, Kainokawa Kainokawa Extract, Kaninote Kaninote Extract, Sangomo Sangomo Extract Genus Hiram caddy extract, centipede spruce extract, centipede genus centipede extract, centipede vine extract, centipede spp. , Centipede spp. Kintoki genus extract, Kintoki nagakintoki extract, Kintoki spruce cadaver extract, Kakateto genus Okinokitoki extract, Nagaobane genus Nagaobane extract, Kakikusa genus Kakikigusa extract, Kinuha genus Kinuhada extract, Tsukasano genus Enkakarimenia extract , Tuscania spp., Hoonoo Honoo extract, Chrysanthemum spp. , Genus genus genus extract, genus genus genus extract, genus genus suskabeni, genus genus extract, genus isomokka extract, genus isomocha extract, genus genus genus extract, genus isodantsu extract, Ogonori Mizoogori Extract, Ogonori Beniogonori Extract, Ogonori Fukureshinori Extract, Ogonori Murasakibibanori Extract, Ogonori Shinkaibanori Extract, Ogonori Togekabanori Extract, Ogonori Kataogonori Extract, Ogonori Ryukyu Extract, scorpion genus scorpion extract, scorpion genus ituginu extract, scorpion genus scorpion extract, scorpion sage extract , Ganoderma genus extract, Namiiwatake genus Namiiwatake extract, Saimi genus extract, Saimi genus extract, Lotus japonicus Lotus jigusa extract, Black-tailed sage extract Madara extract, Taoyagi genus Taoyagisou extract, Taoyagi genus Hanasakura extract, Otsunogi genus Fukutsunagi extract, Otsunogi genus Suikonori extract, Hananoeda genus Hananoeda extract, Hiratoyagi genus Hirataoyagi extract, Darus genus Masagoshibari extract Dulse extract, Weibusa genus Bugaxa extract, Benifukuronori genus Benifukuronori extract, Vaccinium spp. Coral extract, Egonori genus extract, Egonori genus extract, Saeda saeda extract, Chilli maple genus chilli maple extract, Habutaenori extract, Konohanori extract, Suzuronori extract, Usbeni genus extract, Hasujiginu genus extract , Sugiginus genus Sugiginu extract, Sugiginu genus Abususu gininu extract, Heius banori Kagious banori extract, Heius banori genus Yaleus banori extract, haius banori genus suus banori extract, haius banori genus euus banus extract, Ayanishiki Ayanishiki Extract, Ayaginu Ayaginu Extract, Dadia Enasidadia Extract, Shimadadia Isohagi Extract, Shimadadia Shimadadia Extract, Da Prunus spp., Prunus spp. Hyodoschi extract, Hyodosig genus Hyodosigusa extract, Hyodosig genus Usubahiodoshi extract, Isomegusa genus Isomegususa extract, Suginassa genus Sujinashigusa extract, Isobasho genus Isobasho extract, Ideyukogome genus Yukogome extract, Okichimozukoku Red algae extract such as Chisujinori genus Chisujinori extract, Shajikumo extract, Shiratamamo extract, Hoshitsurimo Hoshitsurimo extract, Likunnotumusu extract, Flask genus Himefu Examples thereof include axle algae extracts such as Lascomo extract, chabo flask extract and tripella extract, and yellow algae extracts such as Hikarimo Hikarimo extract.

  Specific examples of ingredients derived from animal raw materials used as additives in the cosmetic composition of the present invention include chicken crown extract, cow, pig or human placenta extract, pig or cow stomach, duodenum, intestine, spleen extract or the like Degradation product, bovine or porcine brain tissue extract, water-soluble collagen, collagen derivatives such as acylated collagen, collagen hydrolyzate, elastin, elastin hydrolysate, water-soluble elastin derivative, keratin and its degradation product or derivatives thereof Silk protein and its degradation products or derivatives thereof, porcine or bovine blood cell protein degradation products (globin peptides), cattle or porcine hemoglobin degradation products (hemin, hematin, heme, protoheme, heme iron, etc.), milk, casein and Decomposition product thereof or derivatives thereof, skim milk powder and decomposition product thereof or derivatives thereof, lactoferrin or decomposition product thereof, egg component And fish meat degradation products, nucleic acid-related substances (ribonucleic acid, deoxyribonucleic acid) and the like.

  Specific examples of components derived from microbial raw materials used as additives in the cosmetic composition of the present invention include yeast metabolites, yeast extract extracts, bacterial metabolites, bacterial extract extracts, metabolites such as fungi or mushrooms, actinomycetes Metabolites, extracts such as fungi or mushrooms, actinomycetes extract, natto metabolites, natto extract, rice fermented extract, rice bran (red rice bran, white birch) fermented extract, euglena extract or decomposed product thereof or water-soluble derivatives thereof Lactic acid fermented product of raw milk or skim milk powder, trehalose or a derivative thereof, and the like.

  As the plant, animal, or microbial raw material, any site, cell, tissue, organ, metabolite, etc. derived from a transgenic or cell fusion can be used. Furthermore, it can be obtained by culturing cells of any site, cell, tissue, organ, etc., for example, cultured cells derived from each tissue (cultures derived from animals such as fibroblasts, Langerhans cells, macrophages, epidermal cells, hepatocytes, etc.) Cells, etc.), undifferentiated cells, cells in the middle of differentiation, metabolites thereof, and the like can also be used.

  Specific examples of the ingredients of the natural product raw materials used as additives include seawater such as deep sea water, for example, sea salt, dried sea water, dead sea or Atlantic or Pacific sea water (sodium chloride, chloride). Magnesium, potassium chloride, etc.), sea mud or mud (Fango), for example, sea mud or mud in various places such as Italian Fango, German Fango, Eifel Fango, Freiburg Fango (Containing components: silicon dioxide, titanium dioxide, aluminum oxide, Iron oxide, manganese oxide, sodium oxide, potassium oxide, magnesium oxide, calcium oxide, strontium oxide, sodium, potassium, magnesium, calcium, chromium, iron, copper, nickel, zinc, lead, manganese, arsenic, water), saintoku stone Natural smectite, bentonite, hectorite and the like.

  Extracts derived from plant raw materials, animal raw materials, microbial raw materials, and other natural product raw materials used as additives are processed in a conventional manner according to the product type and form to be added (for example, pulverization, milling, Treatment, extraction, decomposition, fermentation or metabolic conversion by microorganisms, fractionation, purification, pressing, filtration, drying, pulverization, granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization, etc. ) And any one of various materials may be selected for use.

  The solvent used for extraction may be selected in consideration of the intended purpose and type of the product to be provided or the processing to be performed later. Usually, water, methanol, ethanol, propyl alcohol, isopropyl alcohol, butanol, isopropanol are used. Lower alcohol such as butanol or hydrous lower alcohol, propylene glycol, 1,3-butylene glycol, 1,2-butylene glycol, 1,4-butylene glycol, 1,5-pentanediol, 1,2-pentanediol, 1, 3-pentanediol, 1,4-pentanediol, 1,3,5-pentanetriol, 1,2-hexanediol, 1,5-hexanediol, 1,6-hexanediol, pentylene glycol, hexylene glycol, Polyhydric alcohols such as glycerin and polyethylene glycol (molecular weight 100 to 100,000) or hydrous polyhydric alcohols, , Ethyl acetate, diethyl ether, dimethyl ether, ethyl methyl ether, dioxane, acetonitrile, xylene, benzene, chloroform, carbon tetrachloride, phenol, toluene, and other organic solvents, and acids (hydrochloric acid, sulfuric acid, sulfuric acid, It is desirable to use one or a mixture of two or more selected from nitric acid, phosphoric acid, formic acid, acetic acid, etc.) and alkalis (sodium hydroxide, potassium hydroxide, calcium hydroxide, ammonia, etc.). However, when it is not preferable to contain a solvent depending on the application, it is sufficient to use only water or ethanol that can be easily removed after extraction, and it may be used alone or in any mixture with water. It may be extracted after squeezing.

Regarding the extraction method, the temperature of the solvent, the weight ratio of the solvent to the raw material, or the extraction time can be arbitrarily set for various raw materials and the solvent used.
The temperature of the solvent can be arbitrarily set in the range of −4 ° C. to 100 ° C., but is preferably around 10 to 40 ° C. from the viewpoint of the stability of the components contained in the raw material. Also, the weight ratio of the solvent to the raw material can be arbitrarily set within the range of, for example, the raw material: solvent 4: 1 to 1: 100, and the weight ratio of 1: 1 to 1:10 is particularly preferable.

  Decomposition mainly includes acid decomposition, alkali decomposition, enzyme decomposition, and high-temperature and high-pressure decomposition. In the decomposition with an acid, for example, it is preferable to use an inorganic acid or an organic acid such as hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, acetic acid, formic acid, oxalic acid, hydrogen bromide, perchloric acid, and periodic acid. In the decomposition by alkali, for example, sodium hydroxide, potassium hydroxide, calcium hydroxide, ammonium hydroxide, barium hydroxide, sodium carbonate, ammonium carbonate, calcium carbonate, magnesium hydroxide, sodium silicate, etc. are preferably used. In the decomposition with acid or alkali, the concentration, reaction time, reaction temperature, and the like can be arbitrarily set for the target raw material. In the enzymatic degradation, it is preferable to use an enzyme having a function of degrading proteins, polysaccharides, lipids or complexes thereof having an important function particularly with respect to cell structure, tissue structure, etc., for example, aminopeptidase, dipeptidase, dipeptide Peptidyl peptidase, tripeptidyl peptidase, carboxypeptidase, serine protease, trypsin, chymotrypsin, cysteine protease, thiol protease, papain, aspartate endopeptidase, metalloendopeptidase, bromelain, thermolysin, pronase, pepsin, rennin, pan Proteolytic enzymes (proteases) such as creatine, chymopapain, ficin, collagenase, elastase, amylase, takaamylase, cellulase, hemicellular Polysaccharide-degrading enzymes such as pectinase, polygalacturonase, dextranase, planarase, chicken egg white lysozyme, human lysozyme, papaya lysozyme, turnip lysozyme, barley lysozyme, zymolyce, lysozyme chloride, glucanase, chitinase, etc. Cell wall lytic enzyme. In the degradation with an enzyme, the concentration, reaction time, reaction temperature, pH of the solution, etc. can be set arbitrarily, but it is particularly preferable to set the optimum value for the enzyme used.

  Fermentation or metabolic conversion by microorganisms can be performed by inoculating and growing at least one kind of microorganism on a raw material used as a substrate. Inoculation of microorganisms to the substrate can be done by adding microorganisms directly into the substrate, or by adsorbing them on a carrier such as alginic acid, polyvinyl, gelatin, etc., for example, in the form of fine beads composed of microorganisms and carrier. Further, it can be used by being fixed to the tube wall of the bioreactor. Fermentation or metabolic conversion by microorganisms is not particularly defined as a microorganism to be used, but can generally be defined as microorganisms other than pathogenic microorganisms that exhibit significant toxicity to living bodies. Examples of microorganisms to be used include microorganisms classified into yeasts: Aciculoconidium, Actonia, Aessosporon, Ambrosiozyma, Anthomyces, Apiotrichum, Arthroascus, Arxula, Ashbia, Ashbya, Asporomyces, Atelosaccharomyces Genus, Azymoprocandida, Babjevia, Ballistosporomyces, Bensingtonia, Blastobotrys, Blastodendrion, Blastoderma, Blastoschizomyces, Botryoascus, Botryozyma, Brettanomyces, Brettanomyces bruno, Cullus Genus (Candida albicans, Candida amylolenta, Candida anomala, Candida boidinii, Candida entomaea, Candida etchellsii, Candida famata, Candida fermentati, Candida guilliermondii, Candida halophila, Candida krusei, Candida krusei, Candida krusei, Candida krusei, Candida krusei Candida sake, Candida tropicalis, Candida versatilis, Candida vulgaris, etc.), Castellani Genus a, Chlamydozyma, Chromotorula, Citeromyces, Cladosporium, Clavispora, Crebrothecium, Cryptococcus, Debaryomyces (Debaryomyces delbrueckii, Debaryomyces halotolerans, Debaryomyces hansenii etc.), Deberoozyma, Debaryozyma, Dipodascus, Eeniella, Endomyces, Endomycopsis, Eremascus, Eremothecium, Eutorulopsis, Fabospora, Fellomyces, Filobasidium, Galactomyces, Geotrichoides, Geotrichum, Guilliermondella, anomala, Hansenula kluyveri, Hansenula miso, Hansenula polymorpha, Hansenula wickerhamii, etc.) thermotolerans etc.), Kockovaella genus, Kurtzmanomyces genus, Leucosporidium genus, Lipomyces genus, Metschnikowi genus a, Microanthomyces, Monilia, Monospora, Monosporella, Mrakia, Myceloblastanon, Mycocandida, Mycoderma, Mycotorula, Mycotoruloides, Myxozyma, Nadsonia, Nectaromyces, Nematosporamy, Octosporoces , Oidium genus, Oospora genus, Oosporidium genus, Pachysolen genus, Parasaccharomyces genus, Paratorulopsis genus, Parendomyces genus, Petasopspo spp. , Procandida, Proteomyces, Pseudomonilia, Pseudosaccharomyces, Pseudozyma, Rhodomyces, Rhodosporidium, Rhodotorula, Saccharomyces (Saccharomyces aceti, Saccharomyces cerasi, Saccharomyces cerasi, Saccharomyces , Genus Saccharomycopsis, genus Saturnispora, genus Schizoblastosporion, genus Schizosaccharomyces, Schwanniomyces , Selenotila genus, Selenozyma genus, Smithiozyma genus, Sporidiobolus genus, Sporobolomyces genus, Sporothrix genus, Stephanoascus genus, Sterigmatomyces genus, Sympodiomyces genus, Syringospora genus, Tetrapisispora genus, Torulaspora genus, Torulospoces genus, Torulopsimyces Genus, William genus, Williamopsis genus, Wingea genus, Xanthophyllomyces genus, Yamadazyma genus, Zendera genus, Zygofabospora genus, Zygopichia genus, Zygosaccharomyces genus, Zymodebaryomyces genus and the like. The microorganisms classified as bacteria include the genus Acetobacter (Acetobacter aceti, etc.), Achromobacter genus, Acidianus genus, Acidobacterium genus, Acidithiobacillus genus, Acrocarpospora genus, Actinoalloteichus genus, Actinocorallia genus, Actinokineospora genus, Actinomadospura genus, Actinomadspura Actinosynnema genus, Aerococcus genus, Aeromicrobium genus, Agrobacterium genus, Agromyces genus, Ahrensia genus, Alcaligenes genus, Alicyclobacillus genus, Alloiococcus spp. Aureobacterium genus, Azotobacter genus, Bacillus genus (Bacillus brevis, Bacillus subtilis etc.), Bacteroides genus, Beneckea genus, Bifidobacterium genus (Bifidobacterium bifidum, Bifidobacterium longum, Bifidobacterium breve, Bifidobacterium infantis etc.), Brachybacterium genus, Brevicillus genus, Brevicillus, Brevundimonas, Burkholderia, Carnobacterium, Catellatospora, Cellulomonas sp Enterobacter sp Genus, Halobacterium genus, Halococcus genus, Herbidospora genus, Hydrogenophilus genus, Hyphomicrobium genus, Hyphomonas genus, Intrasporangium genus, Janibacter genus, Kinesia spp. Kocuria, Kurthia, Lactobacillus (Lactobacillus rimae, Lactobacillus divergens, Lactob acillus carnis, Lactobacillus piscicola, Lactobacillus acidophilus, Lactobacillus amylophilus, Lactobacillus animalis, Lactobacillus brevis, Lactobacillus casei, Lactobacillus curvatus, Lactobacillus bulgaricus, Lactobacillus delbrueckii, Lactobacillus fermentum, Lactobacillus fructivorans, Lactobacillus fructosus, Lactobacillus helveticus, Lactobacillus hilgardii, Lactobacillus homohiochii, Lactobacillus kefiri , Lactobacillus malefermentans, Lactobacillus murinus, Lactobacillus paracasei, Lactobacillus paracasei subsp. tolerans, Lactobacillus parakefiri, Lactobacillus pentosus, Lactobacillus plantarum, Lactobacillus reuteri, Lactobacillus rhamnosus, Lactobacillus sakei, Lactobacillus confusus, Lactobacillus viridescens, Lactobacillus johnsonii, Lactobacillus viscosus, Lactobacillus fermentatae, Lactobacillus acidophil-aerogenes, Lactobacillus leichmannii, Lactobacillus gasseri, Lactobacillus bifidus, Lactobacillus jugurt, Lactobacillus caucasicus Lactobacillus arabinosus, Lactobacillus kunkeei, Lactobacillus nagelii, Lactobacillus fornicalis, Lactobacillus pentoaceticus, Lactobacillus xylosus, Lactobacillus minutus, etc.), Leuconostoc genus (Leuconostoc lactis, Leuconostoc dextranicum, Leuconostoc mesenteroides, Leuconostoc oenos, Leuconostoc paramesenteroides, Leuconostoc cremoris, such as Leuconostoc citrovorum), Listonella Genus, Lucibacterium genus, Luteococcus genus, Magnetospirillum genus, Marinilabilia genus, Marinospirillum genus Mesorhizobium genus, Metallosphaera genus, Methylobacterium genus, Microbispora genus, Micrococcus genus, Microellobosporia genus, Micromonospora genus, Mycobacterium genus, Nocoides genus, Noiaides Genus, Nonomuria, Oceanospirillum, Ochrobactrum, Oerskovia, Oligella, Paenibacillus, Pediococcus (Pediococcus cerevisiae, Pediococcus pentosaceus, Pediococcus urinae-equi etc.), Pedobacterto, Pedobacterto , Planobispora, Planococcus, Planomonospora, Prevotella, Propionibacterium, Proteus, Protomonas, Pseudomonas, Pseudonocardia, Rahnella, Rarobacter, Rathayibacter, Rhizobium, Rhizomonas , Rhodospirillum genus, Rothia genus, Rubrobacter genus, Ruegeria genus, Saccharomonospora genus, Saccharothrix genus, Serratia genus, Sinorhizobium genus, Sphingobacterium genus, Sphingomonas genus, Sporolactobacillus genus, Stenotrophomonas genus, Streptoalloteococ genus Streptoalloteococ faecium, Streptococcus bovis, Streptococcus equinus, Streptococcus mutans, Streptococcus salivarius, Streptococcus thermophilus, Streptococcus agalactiae, Streptococcus mitis, Streptococcus pyogenes, Streptococcus pneumoniae, Streptococcus lactisdy uberis, Streptococcus cremoris, Streptococcus diacetilactis, etc.), Streptomyces genus, Streptosporangium genus, Streptoverticillium genus, Terrabacter genus, Thermoactinomyces genus, Thermobifida genus, Thermobispora genus, Thermohispera genus, Thermohispa genus, Thermopispa genus, Thermopispa genus, Thermopispa genus Genus, Xanthobacter genus, Xanthomonas genus, Zymomonas genus and the like. Microorganisms classified as non-yeast ascomycetes, basidiomycetes or incomplete fungi include Allomyces, Amoebidium, Amorphotheca, Arthroderma, Ascoidea, Ascobolus, Ascodesmis, Aspergillus, Aureobasidium, Botryosphaeria Botryotinia sp Genus, Dothidea genus, Endogone genus, Entomophthora genus, Emericella genus, Eupenicillium genus, Eurotium genus, Exobasidium genus, Gibberella genus, Glomus genus, Graphiola genus, Gymnoascus genus, Harpella genus, Helicomyces genus, Helvella genus, Hemicarpenteles genus, Hyphochytrium genus, Hyphochytrium Hypocrea, Laboulbenia, Labyrinthula, Leptosphaeria, Leptosphaerulina, Lophodermium, Melanotaenium, Microascus, Microstroma, Medeololaria, Melampsora , Melamsporella, Morchella, Monascus, Monilinia, Mycospharella, Nannizzia, Nectria, Neolecta, Neurospora, Nodulosphaeria, Olpidium, Peziza, Penicillium, Perenospora, Pestopolisis Genus, Pneumocystis genus, Preussia genus, Pleospora genus, Puccinia genus, Pythium genus, Ravenelia genus, Rickia genus, Rhinocladiella genus, Rhizidiomyces genus, Rhizoctonia genus, Sclerocleista genus, Saprolegnia genus, Sclerotinia genus, Sclerotum genus, Septobasidium genus, Septobasidium genus Sporidiobolus genus, Stigmatomyces genus, Sydowiella genus, Talaromyces genus, Taphrina genus, Thraustochytrium genus, Tolyposporium genus, Trichoglossum genus, Trichoma genus, Ustilago genus, Verticillium genus, Xylaria genus and the like.

  In fermentation or metabolic conversion by microorganisms, in addition to various raw materials such as plant-based materials, animal-based materials, and other natural product-based materials, the growth and metabolism of microorganisms are regulated or activated, and special biosynthesis or degradation pathways are induced. In order to achieve this, various compounds can be added to the raw material. For example, as a carbon source, sugar, ethane such as glucose, fructose, galactose, sucrose, maltose, mannose, lactose, glycerin, starch, etc. , Hydrocarbons such as methane, propane, butane, formic acid, acetic acid, propionic acid, lauric acid, palmitic acid, fatty acids such as oleic acid, linoleic acid, linolenic acid, etc., nitrogen sources such as ammonium sulfate, ammonium hydrochloride, ammonium phosphate, etc. Ammonium salts, urea, uric acid, amino acids, etc. Vitamins and compounds containing potassium, calcium, magnesium, sodium, sulfur, phosphorus, chlorine, etc., as well as iron, copper, zinc, cobalt, nickel, boron, manganese, molybdenum, tin, selenium, silicon It is possible to further add compounds contained in the composition such as arsenic, vanadium, chromium and fluorine. In addition, the optimum temperature, oxygen supply amount, pH, pressure, etc. that affect the growth and metabolic activities of various microorganisms can be arbitrarily set according to the characteristics inherent to various microorganisms. Can be arbitrarily set within the range of 10 to 50 ° C., and the pH can be arbitrarily set within the range of 1 to 14.

  In fractionation or purification, generally known techniques can be used as appropriate. In addition to solvent extraction, for example, liquid chromatography (ion exchange chromatography, ion exclusion chromatography, affinity chromatography, gel filtration chromatography, size exclusion chromatography, etc.). Chromatography, hydrophilic adsorption chromatography, hydrophobic adsorption chromatography, ligand exchange chromatography, etc.), dialysis with semipermeable membrane, crystallization and recrystallization of components, filter paper, membrane filter, ultra filter, Examples thereof include filtration using activated carbon, filter aids, etc., centrifugal separation and its application, such as fractional precipitation method, density gradient separation method such as density gradient sedimentation equilibrium method, and the like.

6). Other compounds used as additives in the cosmetic composition of the present invention
  Specific examples of other compounds used as additives in the cosmetic composition of the present invention include silicic anhydride, magnesium silicate, talc, kaolin, bentonite, hectorite, natural or synthetic smectite, stevensite, mica, mica titanium, Inorganic pigments such as bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide, titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, bengara, black iron oxide, gunjou, chromium oxide, chromium hydroxide, carbon black, calamine , Hydrogen peroxide, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium tripolyphosphate, sodium bromate, potassium bromate, sodium pyrophosphate, orthophosphoric peroxide Sodium Sodium hydrogen peroxide adduct, sodium sulfate hydrogen peroxide adduct, sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution, mushroom extract, strontium sulfate, sodium sulfide, barium sulfide, calcium sulfide, etc. Agents, redox agents such as thioglycolic acid or salts thereof (calcium thioglycolate, sodium thioglycolate, lithium thioglycolate, magnesium thioglycolate, strontium thioglycolate), 5-aminoorthocresol, 2-amino- 4-nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, 3,3'-iminodiphenol, hydrochloric acid 2,4-diaminophenoxyethanol, hydrochloric acid 2,4-diaminophenol, hydrochloric acid Toluene-2,5-diamine, nitroparaphenylene dihydrochloride Min, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, metaphenylenediamine hydrochloride, orthoaminophenol, N-phenylparaphenylenediamine acetate, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5- Dihydroxynaphthalene, toluene-2,5-diamine, toluene-3,4-diamine, nitroparaphenylenediamine, paraaminophenol, paranitroorthophenylenediamine, paraphenylenediamine, paramethylaminophenol, picramic acid, sodium picrate, N N′-bis (4-aminophenyl) -2,5-diamino-1,4-quinonediimine, 5- (2-hydroxyethylamino) -2-methylphenol, N-phenylparaphenylenediamine, metaaminophenol, Metaphenylenediamine, 5-aminoorthocresol sulfate, 2-amino-5-nitrophenol sulfate, orthoaminophenol sulfate, orthochloroparaphenylenediamine sulfate, 4,4'-diaminodiphenylamine sulfate, 2,4-diaminophenol sulfate, toluene-2,5-diamine sulfate, nitrosulfate Paraphenylenediamine, paraaminophenol sulfate, paranitroorthophenylenediamine sulfate, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, paramethylaminophenol sulfate, metaaminophenol sulfate, metaphenylenediamine, catechol, diphenylamine, α-naphthol , Hydroquinone, phloroglucin, 2-hydroxy-5-nitro-2 ', 4'-diaminoazobenzene-5'-sodium sulfonate, dyes such as hematein, natural animals such as musk, civet, castrium, ambergris Sexual perfume, anise essential oil, angelica essential oil, ylang ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, guaiac wood essential oil, cumin essential oil, black letter essential oil, cinnamon essential oil, geranium essential oil, copaiba balsam essential oil , Coriander essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, gingergrass essential oil, cedar essential oil, spearmint essential oil, western peppermint essential oil, otsuki aroma essential oil, tuberose essential oil, clove essential oil, orange flower essential oil, winter green essential oil, true Balsam essential oil, buttery essential oil, rose essential oil, palmarosa essential oil, cocoon essential oil, hiba essential oil, sandalwood essential oil, petit gren essential oil, bay essential oil, vetiva essential oil, bergamot essential oil, peru balsam essential oil, boadrose essential oil, melamine essential oil, mandarin essential oil, eucalyptus essential oil La Essential oil, lavender essential oil, linaloe essential oil, lemongrass essential oil, lemon essential oil, rosemary essential oil, vegetable flavors such as Japanese mint essential oil, other synthetic flavors, 5-amino-o-cresol, o-aminophenol, m-aminophenol, p-aminophenol, 2,6-diaminopyridine, 5- (2-hydroxylethylamino) -2-methylphenol, N, N-bis (β-hydroxyl) -p-phenylenediamine sulfate, N, N-bis (2-hydroxyethyl) -p-phenylenediamine, p-nitro-o-phenylenediamine, p-phenylenediamine, m-phenylenediamine, N-phenyl-p-phenylenediamine, 2-hydroxy-5 -Nitro-2 ', 4'-diaminoazobenzenesodium sulfate, toluene-2,5-diamine, 2- (2'-hydroxyethylamino) -5-aminotoluene, N, N-bis (β-hydroxyl) -p -Phenylenediamine, N, N-bis (2-hydroxyethyl) -p-phenylenediamine sulfate, 5-amino-o-cresol sulfate, p-aminophenol sulfate, o-chloro-p-phenylenediamine sulfate, 2- (2'-hydroxyethyl Amino) -5-aminotoluene sulfate, 4,4'-diaminodiphenylamine sulfate, p-methylaminophenol sulfate, p-phenylenediamine sulfate, m-phenylenediamine sulfate, toluene-2,5-diamine sulfate Salt, 2,4-diaminophenoxyethanol hydrochloride, toluene-2,5-diamine hydrochloride, m-phenylenediamine hydrochloride, 2,4-diaminophenol hydrochloride, 3,3'-iminodiphenol, p-phenylenediamine Hydrochloride, N-phenyl-p-phenylenediamine hydrochloride, N-phenyl-p-phenylenediamine acetate, 1,5-dihydroxynaphthalene, toluene-3,4-diamine, p-methylaminophenol, N, N ' -Bis (4-A Nophenyl) -2,5-diamino-1,4-quinonediimine, o-aminophenol sulfate, 2,4-diaminophenol sulfate, m-aminophenol sulfate, 2-amino-4-nitrophenol, 2-amino -5-nitrophenol, 1-amino-4-methylaminoanthraquinone, nitro-p-phenylenediamine hydrochloride, 1,4-diaminoanthraquinone, nitro-p-phenylenediamine, picramic acid, sodium picrate, 2-amino- 5-nitrophenol sulfate, resorcinol, nitro-p-phenylenediamine sulfate, p-nitro-o-phenylenediamine sulfate, p-nitro-m-phenylenediamine sulfate, red No. 2, red No. 3, red 102 No., Red 104 (1), Red 105 (1), Red 106, Red 201, Red 227, Red 230 (1), Red 230 (2), Red 231, Red 232, Red 401, Red 502, Red 503, Red 504 Red 506, Yellow 4, Yellow 5, Yellow 202 (1), Yellow 202 (2), Yellow 203, Yellow 402, Yellow 403 (1), Yellow 406, Yellow 407 No., Orange No. 205, Orange No. 207, Orange No. 402, Green No. 3, Green No. 204, Green No. 205, Green No. 401, Green No. 402, Brown No. 201, Purple No. 401, Blue No. 1, Blue No. 2, Blue No. 202, Blue No. 203, Blue No. 205, Black No. 401, Red Cabbage Dye, Red Shrimp Dye, Catechol Tannin, Red Rice Dye, Akane Dye, Anato Dye, Squid Dye, Turmeric Dye, Enju Dye, Krill Dye Pigment, caramel, gold, silver, gardenia pigment, corn pigment, onion pigment, tamarind pigment, spirulina pigment, cherry pigment, laver pigment, hibiscus pigment, grape juice pigment, grape skin pigment, marigold pigment, purple potato pigment, purple yam Pigments and coloring agents such as dyes, lac dyes and rutin, avocado Oil, almond oil, fennel oil, sesame oil, olive oil, orange oil, orange rafa oil, sesame oil, cacao butter, chamomile oil, carrot oil, cucumber oil, beef tallow fatty acid, cucumber nut oil, safflower oil, shea butter, liquid shea butter , Soybean oil, camellia oil, corn oil, rapeseed oil, persic oil, castor oil, cottonseed oil, peanut oil, turtle oil, mink oil, egg yolk oil, palm oil, palm kernel oil, owl, coconut oil, beef tallow, lard Fats and oils such as hydrogenated oils (hardened oil, etc.), beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax, montan wax, shellac wax, rice wax, squalene, squalane, pristane, etc. Waxes, liquid paraffin, petrolatum, paraffin, ozokelide, Resin, mineral oil such as microcristan wax, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, linolenic acid, docosahexaenoic acid, eicosapentaenoic acid, 12-hydroxystearic acid, undecylenic acid, Natural fatty acids such as tall oil, lanolin fatty acid, isononanoic acid, caproic acid, 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2-ethylhexanoic acid, isopentanoic acid and other fatty acids such as ethanol, isopyropanol , Lauryl alcohol, cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, phytosterol, phenoxyethanol and other natural alcohols, 2-hexyldecanol, isostearyl alcohol, 2-octyl Synthetic alcohols such as decanol, isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyldodecyl myristate, hexyldecyl dimethyloctanoate, adipine Diisobutyl acid, 2-hexyldecyl adipate, diheptylundecyl adipate, N-alkyl glycol monoisostearate, isocetyl isostearate, trimethylolpropane triisostearate, ethylene glycol diethyl hexanoate, neopentyl glycol diethyl hexanoate, 2- Cetyl ethylhexanoate, trimethylolpropane triethylhexanoate, pentaerythritol tetraethylhexanoate, Chillyl, octyldodecyl gum, cetyl lactate, myristyl lactate, diethyl phthalate, dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate, aluminum stearate, stearic acid Magnesium, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate, etc., anionic surfactants (alkyl carboxylates, alkyl sulfonates, alkyl sulfates, Alkyl phosphate ester salts), alkyl sulfate ester salts (sodium lauryl sulfate, potassium lauryl sulfate, triethanolamine lauryl sulfate, ammonium lauryl sulfate, cetyl Sodium sulfate, sodium stearyl sulfate, etc.), secondary alcohol sulfate, alkyl ether sulfate (for example, polyoxyethylene lauryl sulfate triethanolamine, polyoxyethylene lauryl sodium sulfate, etc.), alkyl and alkyl allyl ether sulfates (N-acyl methyl alanine salt, N-acyl glutamate, N-acyl methyl taurate, N-acyl isethionate, N-acyl glycine salt, alkyl phosphate, alkyl ether carboxylate, alkyl sulfonate, alkyl Sulfosuccinate, sodium polyoxyethylene lauryl ether sulfate, polyoxyethylene lauryl ether sulfate triethanolamine, polyoxyethylene lauryl ether ammonium sulfate, polyoxyethylene alkyl ether Sodium sulfate, polyoxyethylene alkyl ether sulfate triethanolamine, polyoxyethylene alkyl ether sulfate diethanolamine, polyoxyethylene alkyl ether ammonium sulfate, etc.), higher fatty acid alkylolamide sulfate, higher fatty acid ester sulfate (cured coconut oil) Fatty acid sodium glycerine sulfate, etc.), polyoxyethylene alkyl ether carboxylic acid, polyoxyethylene alkyl allyl ether carboxylate, sulfated oil such as sulfated castor oil, mono or dialkyl or alkenyl phosphate ester salt, polyoxyethylene mono or Dialkyl or alkenyl phosphate ester salts (sodium monolauryl phosphate, sodium isostearyl phosphate, arginine 2-hexyldecyl phosphate, 2-heptylun Potassium Shirurin acid, polyoxyethylene (4-10) Lau

Sodium rilether phosphate, sodium monocetyl phosphate, arginine monomyristyl phosphate, sodium monooleyl phosphate, potassium polyoxyethylene (2-10) potassium lauryl ether, sodium dioctyl phosphate, etc.), polyoxyethylene alkyl ether phosphorus Acid ester salts (polyoxyethylene lauryl ether phosphate, polyoxyethylene oleyl ether phosphate, polyoxyethylene cetyl ether phosphate, polyoxyethylene stearyl ether phosphate, polyoxyethylene alkyl ether phosphate, polyoxyethylene alkyl phenyl ether Phosphoric acid, etc.), sulfonates of higher fatty acid amides or sulfonates of higher fatty acid esters (α-olefin sulfonate, N-myristoyl-N-methyltaurine sodium, coconut oil Acid methyl taurine sodium, lauroyl methyl taurine sodium, etc.), alkylbenzene sulfonate (dodecylbenzenesulfonic acid, dodecylbenzenesulfonic acid monoethanolamine, dodecylbenzenesulfonic acid diethanolamine, dodecylbenzenesulfonic acid triethanolamine, sodium dodecylbenzenesulfonic acid, etc.) ), Sulfosuccinate (sodium diethylhexylsulfosuccinate, sodium sulfosuccinate, disodium lauryl sulfosuccinate, disodium polyoxyethylene sulfosuccinate, disodium lauryl polyoxyethylene sulfosuccinate, disodium polyoxyethylene lauroyl ethanolamide ester sulfosuccinate Undecylenoylamidoethylsulfosuccinate, sodium Lauroyl monoethanolamide polyoxyethylene sodium sulfosuccinate, sodium lauryl polypropylene glycol sulfosuccinate, etc.), N-acyl sarcosine salts (such as sodium lauroyl sarcosine, palmitoyl sarcosine sodium), condensates of higher fatty acids and amino acids (N-acyl glutamate, Sodium N-stearoyl glutamate, potassium N-palmitoyl glutamate, sodium N-lauroyl-L-glutamate, disodium N-stearoyl-L-glutamate, sodium N-myristoyl-L-glutamate, sodium myristoyl methyl taurate, sodium palmitoyl methyl taurate, Stearoyl methyl taurine sodium, N-palmitoyl-β-alanine arginine, N-palmitoyl aspartate ditriethanolamine Etc.), anionic surfactants such as fatty acid soaps such as oleate, suarenate, laurate and palmitate (examples of anionic surfactant salts include alkali metals such as sodium salt and potassium salt) Salts, monoethanolamine salts, diethanolamine salts, triethanolamine salts, organic ammonium salts such as L-lysine salts, L-arginine salts, ammonium salts, etc.), quaternary ammonium salts (alkyltrimethylammonium chloride, chloride) Cetyl ammonium, cetyl ammonium bromide, lauryl ammonium chloride, lauryl ammonium bromide, stearyl ammonium chloride, stearyl ammonium bromide, cetyl dimethyl ammonium chloride, cetyl dimethyl ammonium bromide, lauryl dimethyl ammonium chloride, stearyl dimethyl chloride Ammonium, lauryl trimethyl ammonium chloride, lauryl trimethyl ammonium bromide, stearyl dimethyl cetyl ditallow dimethyl ammonium chloride, dicetyl ammonium chloride, dicetyl ammonium bromide, dilauryl ammonium chloride, dilauryl ammonium bromide, distearyl ammonium chloride, odor Distearylammonium chloride, dicetylmethylammonium chloride, dicetylmethylammonium bromide, dilaurylmethylammonium chloride, dilaurylmethylammonium bromide, distearylmethylammonium chloride, distearylmethylammonium bromide, cetyltrimethylammonium chloride, odor Cetyltrimethylammonium chloride, stearyltrimethylammonium chloride, stearyltrimethylammonium bromide, Uryltrimethylammonium chloride, dialkyldimethylammonium chloride, dicetyldimethylammonium chloride, distearyldimethylammonium chloride, dicocoyldimethylammonium chloride, myristyldimethylbenzylammonium chloride, stearyldimethylbenzylammonium chloride, ethyl lanolin fatty acid aminopropylethyldimethylammonium chloride Cetyltrimethylammonium chloride, stearyltrimethylammonium chloride, behenyltrimethylammonium chloride, behenyldimethylhydroxyethylammonium chloride, stearyldimethylbenzylammonium chloride, distearyldimethylammonium chloride, distearoylethylhydroxyethylmonium metasulfate, dicocoylethylhydroxyethyl moni Mumetasulfate, dipalmitoylethylhydroxyethylmonium metasulfate, and cetyltriethylammonium methyl sulfate, alkyltrimethylammonium chloride, alkyldimethylbenzylammonium chloride, dialkyldimethylammonium chloride, alkyltrimethylammonium bromide, alkylpentaethoxyammonium chloride, ditallow Dimethyl ammonium chloride, ditallow dimethyl ammonium methyl sulfate, ditallow dipropyl ammonium phosphate, ditallow dimethyl ammonium nitrate, di (coconut alkyl) dimethyl ammonium chloride, di (coconut alkyl) dimethyl ammonium bromide, coconut ammonium chloride, stearamide propyl PG-dimonium chloride, stearamide Propyl ethyl dimonium esosulphate, stearamide propyl dimethyl (myristyl acetate) ammonium chloride, stearamide propyl dimethyl cetearyl ammonium tosylate, stearamide propyl dimethyl ammonium chloride, stearamide propyl dimethyl ammonium lactate, ethyl lanolin sulfate fatty acid Aminopropylethyldimethylammonium, cationized cellulose, acyldiethylaminoethylamide, acyldimethylaminopropylamide, polyoxyethylene fatty acid amide, myristyldimethylamine oxide, N-lauryldimethylaminoacetic acid betaine, N-myristyldimethylaminoacetic acid betaine, N- Stearyldimethylaminoacetic acid betaine), bis-fatty acid ester salt (hydroxypropyl-bis-lauri) Amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-myristic acid amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-palmitic acid amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl -Bis-stearic acid amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-behenic acid amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-oleic acid amidopropyl-N, N-dimethylammonium Chloride, hydroxypropyl-bis-isostearic acid amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-coconut fatty acid amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-par Fatty acid amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-tallow fatty acid amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-lauramidoethyl-N, N-diethylammonium chloride, hydroxypropyl -Bis-myristic acid amidoethyl-N, N-diethylammonium chloride, hydroxypropyl-bis-palmitic acid amide
Ethyl-N, N-diethylammonium chloride, hydroxypropyl-bis-stearic acid ethyl ethyl-N, N-diethylammonium chloride, hydroxypropyl-bis-behenic acid amidoethyl-N, N-diethylammonium chloride, hydroxypropyl-bis-olein Amidoethyl ammonium chloride, hydroxypropyl-bis-isostearic acid amidoethyl-N, N-diethylammonium chloride, hydroxypropyl-bis-coconut fatty acid amidoethyl-N, N-diethylammonium chloride, hydroxypropyl-bis-palm fatty acid amidoethyl-N , N-diethylammonium chloride, hydroxypropyl-bis-tallow fatty acid amidoethyl-N, N-diethylammonium chloride, hydroxypropyl-bis-lauramide amidopropyl-N, N-diethylan Nitric chloride, hydroxypropyl-bis-myristate amidopropyl-N, N-diethylammonium chloride, hydroxypropyl-bis-amidopropyl palmitate-N, N-diethylammonium chloride, hydroxypropyl-bis-amidopropyl stearate-N , N-diethylammonium chloride, hydroxypropyl-bis-behenate amidopropyl-N, N-diethylammonium chloride, hydroxypropyl-bis-oleic acid amidopropyl-N, N-diethylammonium chloride, hydroxypropyl-bis-isostearic acid Amidopropyl-N, N-diethylammonium chloride, hydroxypropyl-bis-coconut fatty acid amidopropyl-N, N-diethylammonium chloride, hydroxypropyl-bis-palm fatty acid amidopropyl-N, N-die Ammonium chloride, hydroxypropyl-bis-tallow fatty acid amidopropyl-N, N-diethylammonium chloride, etc.), stearamidopropyl PG-dimonium chloride phosphate, behenamidopropyl PG dimonium chloride, stearamide propylethyl dimonium et Cationic surfactants such as sulfate, stearamide propyl dimethyl (myristyl acetate) ammonium chloride, stearamide propyl dimethyl cetearyl ammonium tosylate, stearamide propyl dimethyl ammonium chloride, stearamide propyl dimethyl ammonium lactate, glycerin Fatty acid esters (glyceryl monoundecylate, glyceryl diundecylenate, glyceryl monomyristate, glyceryl dimyristate, monopalmitic acid) Lyseryl, glyceryl dipalmitate, glyceryl monostearate, glyceryl distearate, glyceryl monooleate, mono-cotton oil fatty acid glycerin, glyceryl monoerucate, glyceryl sesquioleate, glyceryl monostearate, α, α'-glycol monooleate pyroglutamate Glyceryl monostearate, etc.), polyglyceryl fatty acid esters (diglyceryl monomyristate, diglyceryl dimyristate, diglyceryl trimyristate, diglyceryl monopalmitate, diglyceryl dipalmitate, diglyceryl tripalmitate) , Diglyceryl monostearate, diglyceryl distearate, diglyceryl tristearate, diglyceryl monooleate, diglyceryl dioleate, triolein Diglyceryl, tetraglyceryl monopalmitate, tetraglyceryl dipalmitate, tetraglyceryl tripalmitate, tetraglyceryl tetrapalmitate, tetraglyceryl pentapalmitate, tetraglyceryl monostearate, tetraglyceryl distearate, tetraglyceryl tristearate, Tetraglyceryl tetrastearate, tetraglyceryl pentastearate, tetraglyceryl monooleate, tetraglyceryl dioleate, tetraglyceryl trioleate, tetraglyceryl tetraoleate, tetraglyceryl pentaoleate, hexaglyceryl monopalmitate, dipalmitic acid Hexaglyceryl, hexaglyceryl tripalmitate, hexaglyceryl tetrapalmitate, pentapal Hexaglyceryl mitinate, hexaglyceryl monostearate, hexaglyceryl distearate, hexaglyceryl tristearate, hexaglyceryl tetrastearate, hexaglyceryl pentastearate, hexaglyceryl monooleate, hexaglyceryl dioleate, hexaglyceryl trioleate , Hexaoleseryl tetraoleate, hexaglyceryl pentaoleate, decaglyceryl monopalmitate, decaglyceryl dipalmitate, decaglyceryl tripalmitate, decaglyceryl tetrapalmitate, decaglyceryl pentapalmitate, decaglyceryl hexapalmitate, hepta Decaglyceryl palmitate, decaglyceryl octapalmitate, decaglyceryl nonapalmitate, decapalmi Decaglyceryl acid, decaglyceryl monostearate, decaglyceryl distearate, decaglyceryl tristearate, decaglyceryl tetrastearate, decaglyceryl pentastearate, decaglyceryl hexastearate, decaglyceryl heptearate, decaglyceryl octastearate Glyceryl, decaglyceryl nonasterate, decaglyceryl decastearate, decaglyceryl monooleate, decaglyceryl dioleate, decaglyceryl trioleate, decaglyceryl tetraoleate, decaglyceryl pentaoleate, decaglyceryl hexaoleate, hepta Decaglyceryl oleate, decaglyceryl octaoleate, decaglyceryl nonaoleate, decaglyceryl dekaoleate, monohydride Decaglyceryl xistate, decaglyceryl dihydroxystearate, decaglyceryl trihydroxystearate, decaglyceryl tetrahydroxystearate, decaglyceryl pentahydroxystearate, decaglyceryl hexahydroxystearate, decaglyceryl heptahydroxystearate, octahydroxystearate Decaglyceryl acid, decaglyceryl nonahydroxystearate, decaglyceryl decahydroxystearate, hexaglyceryl polyricinoleate, decaglyceryl polyricinoleate, polyoxyethylene glyceryl monostearate, polyoxyethylene glyceryl distearate, polyoxymonooleate (Ethylene glycerin, polymyethylene monomyristic acid, etc.) Polyoxyethylene glycerin fatty acid ester (polyoxyethylene glycerin monostearate, polyoxyethylene glycerin monoisostearate, polyoxyethylene glycerin triisostearate, etc.), sorbitan fatty acid ester (sorbitan monolaurate, sorbitan monooleate, sesquiolein) Sorbitan acid, sorbitan trioleate, sorbitan monopalmitate, sorbitan monostearate, sorbitan distearate, sorbitan dipalinate, sorbitan monopalmitate, sorbitan tristearate, sorbitan trisoleate, diglycerin sorbitan penta-2-ethylhexylate Diglycerin sorbitan tetra-2-ethylhexylate, polyoxyethylene sorbitan monooleate, monostearic acid Polyoxyethylene sorbitan, polyoxyethylene sorbitan monopalmitate, polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan trioleate, polyoxyethylene sorbitan pentaoleate, propylene glycol fatty acid ester (propylene glycol monooctanoate, monodecane) Propylene glycol acid, propylene glycol monostearate, etc.), sucrose fatty acid ester (monolauric acid sucrose ester, dilauric acid sucrose ester, monopalmitic acid sucrose ester, dipalmitic acid sucrose ester, monostearic acid sucrose ester, Sucrose esters of distearic acid), dextrin fatty acid esters (dextrin palmitate, etc.), coconut oil fatty acid alkanolamide, polyoxyethylene Castor oil, polyoxyethylene hydrogenated castor oil, polyoxyethylene hydrogenated castor oil monoisostearate, polyoxyethylene hydrogenated castor oil triisostearate, polyoxyethylene hydrogenated castor oil monopyroglutamic acid monoisostearate diester, polyoxyethylene hydrogenated Castor oil maleic acid, polyoxyethylene alkyl ether (alkyl polyglucoside, polyoxyethylene cetyl ether, polyoxyethylene stearyl ether, polyoxyethylene behenyl ether, polyoxyethylene oleyl ether, polyoxyethylene lauryl ether, polyoxyethylene-2 -Octyldodecyl ether, polyoxyethylene cholestanol ether, etc.), polyoxyethylene alkyl phenyl ether (polyoxyethylene nonyl ether) Phenyl ether, polyoxyethylene octyl phenyl ether, etc.), polyoxyethylene fatty acid esters (polyethylene glycol monooleate, polyethylene glycol monostearate, polyethylene glycol monolaurate, etc.), lanolin derivatives (polyoxyethylene lanolin, polyoxyethylene lanolin alcohol) , Polyoxyethylene sorbitol lanolin, etc.), POE / POP-alkyl ether (POE / POP-cetyl ether, POE / POP-2-decyltetradecyl ether, POE / POP-monobutyl ether, POE / POP-hydrogenated lanolin, POE・ POP-glycerin ether, Tetronic, etc.), nonionic surfactants such as alkanolamide (coconut oil fatty acid diethanolamide, lauric acid monoethanolamide, fatty acid isopropanolamide, etc.), betaine-type amphoteric Surfactant (2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine, lauryl dimethylaminoacetic acid betaine, undecyl carboxymethoxyethyl carboxymethyl imidazolinium betaine sodium, undecyl hydroxyethyl imidazolinium betaine sodium , Undecyl-N-hydroxyethyl-N-carboxymethylimidazolinium betaine, alkyldiaminoethylglycine hydrochloride, stearyldihydroxyethylbetaine, stearyldimethylaminoacetic acid betaine, sodium stearyldimethylbetaine, coconut oil alkyl-N-carboxyethyl- N-hydroxyethylimidazolinium betaine sodium, coconut oil alkylbetaine, coconut oil alkyldimethylaminoacetic acid betaine, coconut oil fatty acid amide pro Rubetaine, palm oil fatty acid-N-carboxymethoxyethyl-N-carboxyethylimidazolinium betaine sodium, N-lauroyl-N'-carboxymethyl-N'-hydroxyethylethylenediamine sodium, N-cocoyl-N'-carboxymethyl- N'-hydroxyethyl ethylenediamine sodium, lauryl dimethylaminoacetic acid hydroxysulfobetaine, coconut oil alkyldimethylaminoacetic acid hydroxysulfobetaine, laurylaminopropionic acid triethanolamine, β-laurylaminopropionic acid sodium, lauric acid amidopropyldimethylaminoacetic acid betaine , Lauryl amidopropyl dimethylaminoacetic acid hydroxysulfobetaine, coconut oil fatty acid amidopropyldimethylaminoacetic acid hydroxysulfobetaine, palm oil fatty acid amidop Propyl dimethylaminoacetic acid hydroxysulfobetaine, palm oil fatty acid amidopropyl dimethylaminoacetic acid betaine, palm oil fatty acid amidopropyldimethylaminoacetic acid betaine, lauryl-N-carboxymethoxyethyl-N-carboxymethylimidazolinium disodium dodecanoyl sarcosine, Sodium lauryldiaminoethylglycine, amidopropyl betaine laurate solution, lauryl sulfobetaine, lauryl hydroxysulfobetaine, 2-heptadecyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, cocodimethylcarboxymethylbetaine, lauryldimethylcarboxymethyl Betaine, lauryl dimethyl alpha carboxyethyl betaine, cetyl dimethyl carboxymethyl betaine, cetyl dimethyl betaine , Raurirubisu - (2-hydroxyethyl) carboxymethyl betaine, stearyl - (2-hydroxypropyl) carboxymethyl betaine, oleyl dimethyl gamma -

Carboxypropylbetaine, Laurylbis- (2-hydroxypropyl) alpha-carboxyethylbetaine, Cocodimethylsulfopropylbetaine, Stearyldimethylsulfopropylbetaine, Lauryldimethylsulfoethylbetaine, Laurylbis- (2-hydroxyethyl) sulfopropylbetaine, Levon 2000 (Sanyo Kasei Co., Ltd.), coconut oil fatty acid amidopropyldimethylbetaine, coconut oil fatty acid amidopropylsulfobetaine, imidazolinium type amphoteric surfactant (bis (stearyl-N-hydroxyethylimidazoline) chloroacetic acid complex, N-alkyl- N-carboxymethyl-N-hydroxyethylimidazolinium betaine, N-alkyl-N-carboxymethyl-N-hydroxyethylethylenediamine lauryl sulfate and its salts, palm oil alkyl-N-carboxyethoxy Ethyl-N-carboxyethyl imidazolinium disodium hydroxide, coconut oil alkyl-N-carboxymethoxyethyl-N-carboxyethyl imidazolinium disodium hydroxide, coconut oil alkyl-N-carboxymethoxyethyl-N-carboxyethyl Imidazolinium disodium lauryl sulfate, 2-undecyl-N, N, N- (hydroxyethylcarboxymethyl) -2-imidazoline sodium, 2-cocoyl-2-imidazolinium hydroxide-1-carboxyethyloxy disodium salt , Obazoline 662 (Toho Chemical Co., Ltd.), Swanol AM-101 (Nikko Chemicals Co., Ltd.), Aminopropionic acid type amphoteric surfactants (alkylaminopropionic acid such as sodium dodecylaminopropionate, alkylaminodipropionic acid, etc.), dodecyl Sodium aminopropanesulfonate, N-high Alkyl aspartic acid or salts thereof, coamidopropyl chlorinated polyethylene glycol dimonium phosphate, cocamidopropyl hydroxysultain, sodium lauroyl sarcosinate, alkyl amine oxide (decyl amine oxide, coco amine oxide, myristoyl amine oxide, palmitoyl amine oxide, Amphoteric surfactants such as alkyldimethylamine oxide and alkylamidopropylamine oxide), natural surfactants (lecithin, sodium caseinate, sphingolipid, saponin, mannosyl polyhydric alcohol fatty acid ester, glucosyl polyhydric alcohol fatty acid ester, galactosyl) Monosaccharide polyhydric alcohol fatty acid ester such as polyhydric alcohol fatty acid ester or disaccharide polyhydric alcohol fatty acid ester, oligosaccharide polyhydric alcohol Fatty acid esters) and amino acid surfactants (capric acid chloride, lauric acid chloride, myristic acid chloride, palmitic acid chloride, stearic acid chloride, oleic acid chloride, behenic acid chloride, coconut oil fatty acid chloride, etc.) and glycine , Sarcosine, β-alanine, N-methyl-β-alanine, taurine, N-methyltaurine and other broadly defined amino acids), silicone surfactants (silicon KF-6011 (Shin-Etsu Chemical Co., Ltd.), KF-6012 (Shin-Etsu Chemical Co., Ltd.), KF-6013 (Shin-Etsu Chemical Co., Ltd.), KF-6015 (Shin-Etsu Chemical Co., Ltd.), KF-6016 (Shin-Etsu Chemical Co., Ltd.), KF-6017 (Shin-Etsu Chemical) Industrial company), X-22-4991 (manufactured by Shin-Etsu Chemical Co., Ltd.), NUC silicon L7002 (manufactured by Nihon Unicar), SH-3772C (manufactured by Toray Dow Corning Silicone), SH-3775C (manufactured by Toray Dow Corning Silicone) ) And other polyoxyalkylene-modified organopolysiloxanes, ABIL EM-90 (Gold Schmidt), ABIL B9806 (Gold Schmidt), Silicon KF-6026 (Shin-Etsu Chemical Co., Ltd.) Oxyalkylene-modified organopolysiloxane, etc.), polyether-modified silicone (polyoxyethylene / methylpolysiloxane copolymer, poly (oxyethylene / oxypropylene) methylpolysiloxane copolymer, etc.), oxazoline-modified organopolysiloxane, alkyl-modified Organopolysiloxane, styryl ketone silicone derivative, dimethylpolysiloxane, methylphenylpolysiloxane, epoxy modified silicone, fluorine modified silicone, alcohol modified silicone, alkyl modified silicone, alkoxy modified silicone, amino modified silicone , Ammonium-modified polymer silicone, organopolysiloxane, methylphenylpolysiloxane, polysiloxane, poly (N-acylalkyleneimine) -modified silicone, dimethylpolysiloxane, nitrogen-containing acrylic-silicone graft copolymer, decamethylcyclohexane Pentasiloxane, fluorine-substituted alkyl-modified silicone, organopolysiloxanylsilylalkyl-modified silicone, tricyclic diterpenecarboxylic acid-modified silicone, trifluoroalkyl-modified silicone, divinylpolydimethylsiloxane, dihydrogenopolydimethylsiloxane, dihydrogenopolydimethyl Siloxane divinyl polydimethylsiloxane polymer, trimethylsiloxysilicic acid, polyoxypropylene / methylpolysiloxane copolymer, ethyl polysiloxa , Ethylmethylpolysiloxane, ethylphenylpolysiloxane, octamethylcyclotetrasiloxane, diorganopolysiloxane, octamethylcyclotetrasiloxane, tetramethyltetraphenyltetracyclosiloxane, polyether-modified polysiloxane, amino-modified polysiloxane, epoxy-modified Silicone compounds such as polysiloxane, fluorine-modified polysiloxane, alcohol-modified polysiloxane, alkyl-modified polysiloxane, dodecamethylcyclohexasiloxane, laurylmethicone copolyol, aminoethylaminopropylsiloxane / dimethylsiloxane copolymer, eugenol-modified silicone , Selenium disulfide, alkylisoquinolinium bromide solution, zinc pyrithione, biphenamine, thianthol, quinine hydrochloride, Aqueous ammonia hair treatment agents such like.

  Others, hormones, sequestering agents, pH adjusters, chelating agents, antiseptic / antibacterial agents, refreshing agents, stabilizers, emulsifiers, animal / plant proteins and their degradation products, animal / plant polysaccharides and their Degradation products, animal / plant glycoproteins and their degradation products, anti-inflammatory agents, antiallergic agents, wound treatment agents, foaming agents, thickeners, enzymes, purified water (electronic water, small clustering, etc.), deodorant / A deodorant etc. can be used in combination.

  Hereinafter, the present invention will be described in more detail with reference to examples, but the present invention is not limited thereto.

[Synthesis Example 1]
10.0 g of ε-polylysine (number average molecular weight 4090) and 30 g of methanol were placed in a 100 ml three-necked flask equipped with a porcelain stirrer, condenser, and thermometer, and stirred at room temperature to dissolve ε-polylysine. Next, after raising the temperature to 50 ° C., 2.1 g (8.05 × 10 ⁻³ mol) of (3-glycidoxypropyl) -pentamethyldisiloxane represented by the following formula (9) was added dropwise over 5 minutes, The reaction was carried out for 3 hours while maintaining a temperature of 50 ° C. After 3 hours, the reaction solution was cooled, and 10.0 g of ethanol was added. Next, the volatile matter in the reaction solution was distilled off under reduced pressure using an evaporator to obtain 11.8 g of pentamethylsiloxane-containing ε-polylysine as a slightly yellow solid as a product.

[Synthesis Example 2]
10.0 g of ε-polylysine (number average molecular weight 4090) and 30.0 g of methanol were placed in a 100 ml three-necked flask equipped with a porcelain stirrer, a condenser, and a thermometer, and stirred at room temperature to dissolve ε-polylysine. Next, 20.0 g of 2-propanol was added, and after raising the temperature to 70 ° C., 2.9 g of polydimethylsiloxane having a one-terminal epoxy group represented by the following formula (10) and having a number average molecular weight of 1000 was dropped in 5 minutes. The reaction was carried out for 3 hours while maintaining a temperature of 70 ° C. After cooling the reaction solution to room temperature, volatile components in the reaction solution were distilled off under reduced pressure using an evaporator to obtain 12.6 g of polydimethylsiloxane-containing ε-polylysine as a slightly yellow solid as a product. The residual ratio of the number of amino groups in this compound was 97%, and silicone / ε-polylysine = 23/77 (weight ratio).

［合成例３］
磁器攪拌子、冷却管、温度計を取り付けた１００ミリリットルの三ツ口フラスコに、ε−ポリリジン（数平均分子量＝4090）５．０ｇ、メタノールを３０．０ｇ入れ、室温にて攪拌し、ε−ポリリジンを溶解した。温度を５０℃に昇温後、上記の式（９）で表される（３−グリシドキシプロピル）−ペンタメチルジシロキサン５．０ｇ（３３．８×１０^-3ｍｏｌ）を１０分間で滴下した。５０℃の温度を保持した状態で３時間反応させた。３時間経過後、反応液を冷却し、エタノールを１０．０ｇ加えた。次に、エバポレーターを用いて反応液中の揮発分を減圧溜去し、生成物として１０．０ｇの黄色の水飴状化合物であるペンタメチルシロキサン含有ε−ポリリジンを得た。このポリマーのアミノ基数の残存率は５０％、シリコーン／ε−ポリリジン＝５０／５０（重量比）であった。
［合成例４］
磁器攪拌子、冷却管、温度計を取り付けた１００ミリリットルの三ツ口フラスコに、ε−ポリリジン（数平均分子量＝４０９０）５．０ｇ、メタノールを２０．０ｇ入れ、室温にて攪拌し、ε−ポリリジンを溶解した。次いで２−プロパノールを２０．０ｇ加え、温度を７０℃に昇温後、上記の式（１０）で用いたのと同様の片末端エポキシ基をもつ数平均分子量１０００のポリジメチルシロキサン５．０ｇを５分間で滴下した。５０℃の温度を保持した状態で３時間反応させた。反応液を室温に冷却後、エバポレーターを用いて反応液中の揮発分を減圧溜去し、生成物として９．９ｇの微黄色の固体であるポリジメチルシロキサン含有ε−ポリリジンを得た。このポリマーのアミノ基数の残存率は９１％、シリコーン／ε−ポリリジン＝５０／５０（重量比）であった。
［合成例５］
磁器攪拌子、冷却管、温度計を取り付けた１００ミリリットルの三ツ口フラスコに、ε−ポリリジン（数平均分子量＝４０９０）５．００ｇ、メタノールを２０．０ｇ入れ、室温にて攪拌し、ε−ポリリジンを溶解した。次いで２−プロパノールを２０．０ｇ加え、温度を５０℃に昇温後、下記の式（１１）で表される片末端エポキシ基をもつ数平均分子量５０００のポリジメチルシロキサン６．１２ｇを５分で滴下した。７０℃の温度を保持した状態で３時間反応させた。反応液を室温に冷却後、エバポレーターを用いて反応液中の揮発分を減圧溜去し、生成物として１１．１ｇの微黄色の固体であるポリジメチルシロキサン含有ε−ポリリジンを得た。このポリマーのアミノ基数の残存率は９７％、シリコーン／ε−ポリリジン＝５５／４５（重量比）であった。

［合成例６］
磁器攪拌子、冷却管、温度計を取り付けた１００ミリリットルの三ツ口フラスコに、ε−ポリリジン（数平均分子量＝４０９０）２．００ｇ、メタノールを２０．０ｇ入れ、室温にて攪拌し、ε−ポリリジンを溶解した。次いで２−プロパノールを２０．０ｇ加え、温度を５０℃に昇温後、上記の式（１１）で表される片末端エポキシ基をもつ数平均分子量５０００のポリジメチルシロキサン９．１４ｇを５分間で滴下した。７０℃の温度を保持した状態で３時間反応させた。反応液を室温に冷却後、エバポレーターを用いて反応液中の揮発分を減圧溜去し、生成物として１１．０ｇの微黄色の液体であるポリジメチルシロキサン含有ε−ポリリジンを得た。このポリマーのアミノ基数の残存率は９１％、シリコーン／ε−ポリリジン＝８０／２０（重量比）であった。
［合成例７］
磁器攪拌子、冷却管、温度計を取り付けた１００ミリリットルの三ツ口フラスコに、ε−ポリリジン（数平均分子量＝４０９０）３．０ｇ、メタノールを２０．０ｇ入れ、室温にて攪拌し、ε−ポリリジンを溶解する。温度を５０℃に昇温後、上記の式（１０）で用いたのと同様の片末端エポキシ基をもつ数平均分子量１０００のポリジメチルシロキサン１０．０ｇを１０分間で滴下した。５０℃の温度を保持した状態で３時間反応させた。３時間経過後、反応液を冷却し、エタノールを１０．０ｇ加えた。次に、エバポレーターを用いて反応液中の揮発分を減圧溜去し、生成物として１２．６ｇの黄白色の高粘度な液体であるポリジメチルシロキサン含有ε−ポリリジンを得た。
［合成例８］
磁器攪拌子、冷却管、温度計を取り付けた１００ミリリットルの三ツ口フラスコに、ε−ポリリジン（数平均分子量＝４０９０）１０．０ｇ、メタノールを３０．０ｇ入れ、室温にて攪拌し、ε−ポリリジンを溶解する。温度を３０℃に昇温後、下記の式（１２）で表される片末端にカルボン酸基をもつ数平均分子量１０００のポリジメチルシロキサン３．１ｇを５分で滴下した。３０℃の温度を保持した状態で１時間反応させた。１時間経過後、反応液を冷却し、エタノールを１０．０ｇ加えた。次に、エバポレーターを用いて反応液中の揮発分を減圧溜去し、生成物として１１．６ｇの微黄色の固体を得た。また、該化合物の赤外吸収スペクトルにおいて、ε−ポリリジンに起因する吸収とポリジメチルシロキサン起因の吸収が認められた（図１）。また、該化合物は水には全く溶けない為、水洗により未反応のε−ポリリジンを除去後、ヘキサンに溶解し、０．１Ｎ塩酸水にて処理したところ、水層にε−ポリリジンが得られた。従って、本反応で得られた化合物は、ε−ポリリジンと下記の式（８）のアンモニウム塩であり、ポリジメチルシロキサン含有ε−ポリリジンであることが判った。

[Synthesis Example 3]
In a 100 ml three-necked flask equipped with a porcelain stirrer, condenser, and thermometer, 5.0 g of ε-polylysine (number average molecular weight = 4090) and 30.0 g of methanol were stirred and stirred at room temperature. Dissolved. After raising the temperature to 50 ° C., 5.0 g (33.8 × 10 ⁻³ mol) of (3-glycidoxypropyl) -pentamethyldisiloxane represented by the above formula (9) was added dropwise over 10 minutes. did. The reaction was carried out for 3 hours while maintaining a temperature of 50 ° C. After 3 hours, the reaction solution was cooled, and 10.0 g of ethanol was added. Next, the volatile matter in the reaction solution was distilled off under reduced pressure using an evaporator to obtain 10.0 g of a yellow syrup-like compound containing pentamethylsiloxane and ε-polylysine as a product. The residual ratio of the number of amino groups of this polymer was 50%, and silicone / ε-polylysine = 50/50 (weight ratio).
[Synthesis Example 4]
In a 100 ml three-necked flask equipped with a porcelain stirrer, condenser, and thermometer, 5.0 g of ε-polylysine (number average molecular weight = 4090) and 20.0 g of methanol were added and stirred at room temperature. Dissolved. Next, 20.0 g of 2-propanol was added, and after raising the temperature to 70 ° C., 5.0 g of polydimethylsiloxane having a number-average molecular weight of 1000 having a single-end epoxy group similar to that used in the above formula (10) was added. Added dropwise over 5 minutes. The reaction was carried out for 3 hours while maintaining a temperature of 50 ° C. After cooling the reaction solution to room temperature, volatile components in the reaction solution were distilled off under reduced pressure using an evaporator to obtain 9.9 g of polydimethylsiloxane-containing ε-polylysine as a slightly yellow solid as a product. The residual ratio of the number of amino groups of this polymer was 91%, and silicone / ε-polylysine = 50/50 (weight ratio).
[Synthesis Example 5]
In a 100 ml three-necked flask equipped with a porcelain stirrer, condenser, and thermometer, 5.00 g of ε-polylysine (number average molecular weight = 4090) and 20.0 g of methanol were added and stirred at room temperature. Dissolved. Next, 20.0 g of 2-propanol was added, and after raising the temperature to 50 ° C., 6.12 g of a polydimethylsiloxane having a number-average molecular weight of 5000 having a one-end epoxy group represented by the following formula (11) was added in 5 minutes. It was dripped. The reaction was carried out for 3 hours while maintaining a temperature of 70 ° C. After cooling the reaction solution to room temperature, the volatile matter in the reaction solution was distilled off under reduced pressure using an evaporator to obtain 11.1 g of polydimethylsiloxane-containing ε-polylysine as a slightly yellow solid. The residual ratio of the number of amino groups of this polymer was 97%, and silicone / ε-polylysine = 55/45 (weight ratio).

[Synthesis Example 6]
In a 100 ml three-necked flask equipped with a porcelain stirrer, condenser, and thermometer, 2.00 g of ε-polylysine (number average molecular weight = 4090) and 20.0 g of methanol were added and stirred at room temperature. Dissolved. Next, 20.0 g of 2-propanol was added, the temperature was raised to 50 ° C., and 9.14 g of a polydimethylsiloxane having a number-average molecular weight of 5000 having a one-end epoxy group represented by the above formula (11) was added over 5 minutes. It was dripped. The reaction was carried out for 3 hours while maintaining a temperature of 70 ° C. After cooling the reaction solution to room temperature, the volatile matter in the reaction solution was distilled off under reduced pressure using an evaporator to obtain 11.0 g of polydimethylsiloxane-containing ε-polylysine as a slightly yellow liquid. The residual ratio of the number of amino groups of this polymer was 91%, and silicone / ε-polylysine = 80/20 (weight ratio).
[Synthesis Example 7]
In a 100 ml three-necked flask equipped with a porcelain stirrer, condenser, and thermometer, 3.0 g of ε-polylysine (number average molecular weight = 4090) and 20.0 g of methanol were stirred and stirred at room temperature. Dissolve. After raising the temperature to 50 ° C., 10.0 g of polydimethylsiloxane having a number-average molecular weight of 1000 having a single-end epoxy group similar to that used in the above formula (10) was added dropwise over 10 minutes. The reaction was carried out for 3 hours while maintaining a temperature of 50 ° C. After 3 hours, the reaction solution was cooled, and 10.0 g of ethanol was added. Next, the volatile matter in the reaction solution was distilled off under reduced pressure using an evaporator to obtain 12.6 g of a polydimethylsiloxane-containing ε-polylysine as a yellowish white highly viscous liquid as a product.
[Synthesis Example 8]
In a 100 ml three-necked flask equipped with a porcelain stirrer, condenser, and thermometer, 10.0 g of ε-polylysine (number average molecular weight = 4090) and 30.0 g of methanol were added and stirred at room temperature. Dissolve. After raising the temperature to 30 ° C., 3.1 g of polydimethylsiloxane having a number average molecular weight of 1000 having a carboxylic acid group at one end represented by the following formula (12) was added dropwise over 5 minutes. The reaction was carried out for 1 hour while maintaining a temperature of 30 ° C. After 1 hour, the reaction solution was cooled, and 10.0 g of ethanol was added. Next, the volatile matter in the reaction solution was distilled off under reduced pressure using an evaporator to obtain 11.6 g of a slightly yellow solid as a product. Further, in the infrared absorption spectrum of the compound, absorption caused by ε-polylysine and absorption caused by polydimethylsiloxane were observed (FIG. 1). In addition, since the compound does not dissolve in water at all, after removing unreacted ε-polylysine by washing with water, it is dissolved in hexane and treated with 0.1N hydrochloric acid to obtain ε-polylysine in the aqueous layer. It was. Therefore, it was found that the compound obtained by this reaction was ε-polylysine and an ammonium salt of the following formula (8), and was polydimethylsiloxane-containing ε-polylysine.

[Example 1]
The compound obtained in Synthesis Example 1 was diluted with methanol to prepare a 10.0 wt% methanol solution. Next, 1000 ppm 1,3-butylene glycol-containing purified water was used to prepare the compound obtained in Synthesis Example 1 at 6.25 ppm, 12.5 ppm, 25 ppm, 50 ppm, 100 ppm, 200 ppm, 400 ppm, and 800 ppm.

[Example 2]
The compound obtained in Synthesis Example 2 was diluted with methanol to prepare a 10.0 wt% methanol solution. Next, 1000 ppm glycerin-containing purified water was used so that the compound obtained in Synthesis Example 2 would be 6.25 ppm, 12.5 ppm, 25 ppm, 50 ppm, 100 ppm, 200 ppm, 400 ppm, 800 ppm.

[Comparative Example 1]
The compound obtained in Synthesis Example 1 was diluted with methanol to prepare a 10.0 wt% methanol solution. Next, using purified water, as Comparative Example 1, the compound obtained in Synthesis Example 1 was prepared to be 6.25 ppm, 12.5 ppm, 25 ppm, 50 ppm, 100 ppm, 200 ppm, 400 ppm, and 800 ppm.

[Comparative Example 2]
The compound obtained in Synthesis Example 2 was diluted with methanol to prepare a 10.0 wt% methanol solution. Next, using purified water, the compound obtained in Synthesis Example 2 as Comparative Example 2 was prepared to be 6.25 ppm, 12.5 ppm, 25 ppm, 50 ppm, 100 ppm, 200 ppm, 400 ppm, and 800 ppm.

(Antiseptic antibacterial effect test)
About each preparation of Examples 1-2 and Comparative Examples 1-2, the antiseptic antibacterial effect with respect to colon_bacillus | E._coli (Escherichia coli IFO3972) was measured. As a medium used for the test, 4.5 mL of normal bouillon medium (hereinafter referred to as NB medium) was dispensed into a test tube, capped with an aluminum cap, and then autoclaved at 121 ° C, 1.1 kPa for 15 minutes. Was used. 0.5 mL of each preparation of Examples 1 and 2 and Comparative Examples 1 and 2 was added to the total amount of sterilized NB medium, and the mixture was stirred well and dispersed uniformly. Next, 0.1 mL of a pre-cultured Escherichia coli suspension was inoculated so that the initial bacterial count in each medium was 1 × 10 ⁵ cells / mL, followed by shaking culture in a 36 ° C. incubator for 48 hours. After completion of the culture, the growth of the bacteria was visually determined. The criterion was the presence or absence of white turbidity of the medium accompanying the growth of the bacteria. The system in which the white turbidity of the medium was observed was indicated as +, and the system in which the white turbidity of the medium was not observed was indicated as-. The results are shown in Table 1.

  From the results of Examples 1-2 and Comparative Examples 1-2 in Table 1, the system containing polyorganosiloxane-containing ε-polylysine and polyhydric alcohol is compared with the system containing only polyorganosiloxane-containing ε-polylysine. It was revealed that E. coli exhibits a high antiseptic and antibacterial effect at a significantly low content. Therefore, by using polyorganosiloxane-containing ε-polylysine in combination with a polyhydric alcohol, it is possible to reduce the content of polyorganosiloxane-containing ε-polylysine in the cosmetic composition that has the desired antiseptic antibacterial effect. It turned out to be.

(Production example of cosmetic composition)
Various cosmetic compositions according to the present invention were prepared. Although the manufacture example is shown below, this invention is not necessarily limited to these.

(Production Example 1) Emulsion weight%
Polyether-modified organopolysiloxane 5.0
Diglyceryl monostearate 1.5
Decamethylcyclotetrasiloxane 20.0

Dimethylpolysiloxane 10.0

Liquid paraffin 10.0

Fragrance 0.1
Compound of Synthesis Example 1 0.1
1,3-butylene glycol 15.0

Sodium chloride 0.2
Purified water remaining

(Manufacturing example 2) Beauty liquid weight%
Sorbitan sesquiisostearate 3.0
Decamethylcyclopentasiloxane 10.0

Isononyl isomyristate 8.0
Perfluoropolyether 0.5
Fragrance 0.1
Compound of Synthesis Example 2 0.05
Glycerin 3.0
Propylene glycol 10.0

Ascorbic acid-2 glucoside 3.0
Sodium citrate 0.5
Purified water remaining

(Production Example 3) Cream weight%
Vaseline 8.0
N- (3-hexadecyloxy-2-hydroxypropyl)
-N-2-Hydroxyethylhexadecanamide 2.0

Squalene 20.0

Cetanol 5.0
Glycerol monostearate2.0
Polyoxyethylene (20)
Sorbitan monolaurate 2.0
Arginine 0.1
Ceramide 3 0.5
Sodium monohydrogen phosphate 0.85
Compound of Synthesis Example 1 0.2
Glycerin 5.0
1,3-butylene glycol 5.0
Dimethylpolysiloxane 3.0
Fragrance 0.1
Purified water remaining

(Production Example 4) Lotion weight%
Sorbitol 2.0
1,3-butylene glycol 4.0
Compound of Synthesis Example 2 1.0
Polyoxyethylene (25) oleyl ether 2.0
Carboxyvinyl polymer 0.2
Ethanol 15.0

Purified water remaining

(Production Example 5) Foundation weight%
Decamethylcyclopentasiloxane 45.0

Dimethylpolysiloxane 5.0
Dimethyl distearyl ammonium hectorite 4.0
Hydrophobized titanium oxide 10.0

Hydrophobic talc 6.0
Hydrophobized mica 6.0
Hydrophobic treatment Bengala 1.6
Hydrophobized yellow iron oxide 0.7
Hydrophobized black iron oxide 0.2
Compound of Synthesis Example 1 0.1
Dipropylene glycol 5.0
2-Amino-2-methyl-1,3-propanediol 0.5
Fragrance 0.1
Purified water remaining

(Production Example 6) Liquid foundation weight%
Decamethylcyclopentasiloxane 16.0

Dimethylpolysiloxane 8.0
12-hydroxystearic acid 1.0

Fluorine-modified silicone 5.0
Spherical silicone resin powder 3.0
Fluorine compound-treated fine particle titanium oxide 8.0
Fluorine compound-treated mica titanium 1.0
Fluorine compound-treated titanium oxide 5.0
Fluorine compound treated bengara 0.9
Fluorine compound-treated yellow iron oxide 2.0
Fluorine compound-treated black iron oxide 1.0
Ethanol 15.0

Compound of Synthesis Example 2 0.5
1,6-hexanediol 2.0
Glycerin 3.0
Magnesium sulfate 1.0
Fragrance 0.05
Purified water remaining

(Production Example 7) Lipstick Weight%
Cadilla wax 5.0
Ceresin wax 15.0

Beeslow 3.0
Decamethylcyclopentasiloxane 15.0

Propylene glycol dicaprate 10.0

Polyglyceryl diisostearate8.0
Sorbitan sesquioleate 1.0
Polyether-modified organopolysiloxane 2.0
Compound of Synthesis Example 1 0.05
1,3-butylene glycol 1.0
Red 201 No.1.5

Yellow No. 401 1.0

Hydrophobized titanium oxide 1.0
Hydrophobic treated mica titanium 5.0
Fragrance 1.0
Cetyl isooctanoate

(Production Example 8) Eyeshadow Weight%
Decamethylsiloxane 15.0

Dimethylpolysiloxane 10.0

Polyethylene glycol (10) lauryl ether 0.5
Silicone-treated chromium oxide 6.5
Silicone treated ultramarine 4.0
Silicone-treated titanium-coated mica 6.0
Sodium chloride 2.0
Propylene glycol 8.0
Compound of Synthesis Example 2 0.5
Fragrance 0.1
Purified water remaining

(Production Example 9) Face wash weight%
Lauryl phosphate triethanolamine 18.0

Lauric acid triethanolamine 2.5
Myristic acid triethanolamine 2.5
Compound of Synthesis Example 1 0.2
Glycerin 16.0

Triisostearic acid polyoxyethylene (160) sorbitan 2.0

Cationized cellulose 0.5
Acrylic acid methacrylate alkyl copolymer 0.5
Lauryl hydroxysulfobetaine 5.0
Fragrance 0.1
Purified water remaining

(Production Example 10) Body shampoo% by weight
Sodium citrate 2.0
N-acetylglutamic acid 1.0
Potassium laurate 15.0

Potassium myristate 5.0
Compound of Synthesis Example 2 0.3
Propylene glycol 5.0
Sorbitol 3.0
Methylpolysiloxane 1.5
Amino-modified dimethylpolysiloxane 2.5
Polyethylene powder 0.5
Hydroxypropyl chitosan 0.5
Fragrance 0.1
Purified water remaining

(Production Example 11) Hair styling weight%
Vinylpyrrolidone /
N, N-dimethylaminoethyl methacrylic acid copolymer diethyl sulfate 1.0
Polyoxyethylene hydrogenated castor oil 0.3
Keratin hydrolyzate 1.0
Hydroxypropyl chitosan 3.5
Acetylneuraminic acid 0.1
Compound of Synthesis Example 1 0.05
Mannitol 4.0
1,3-butylene glycol 5.0
Ethanol 10.0

Fragrance 0.1
Purified water remaining

(Production Example 12) Shampoo% by weight
Stearyldimethylamine 0.1
Cetyldimethylamine 0.1
Cetanol 0.5
Carboxyvinyl polymer 0.4
Isopropyl palmitate 1.6
Dimethylpolysiloxane 0.7
Dimethylpolysiloxane 0.3
Lauryldimethylamine oxide 10.0

Laurylcarboxymethyl hydroxyethylimidazolinium betaine 1.0
Cationized cellulose 0.5
Compound of Synthesis Example 1 0.5
Propylene glycol 0.5
Ethylene glycol distearate 2.0
Sodium citrate 0.2
Fragrance 0.1
Purified water remaining

(Production Example 13) Rinse weight%
Dialkyldimethylammonium chloride 3.0
Polyoxyethylene (5) lauryl ether 5.0

Isostearyl glyceryl ether 2.0
Compound of Synthesis Example 2 0.8
1,2-pentanediol 1.5
Hydroxypropyl cellulose 0.4
Isopropyl palmitate 1.6
Dimethylpolysiloxane 0.1
Citric acid 0.5
Fragrance 0.1
Purified water remaining

(Production Example 14) Treatment weight%
Behenyltrimethylammonium chloride 8.0
Behenyl alcohol 7.0
Carboxymethylchitin 1.0
Isopropyl palmitate 9.0
Dimethylpolysiloxane 1.0
Monostearic acid Polyoxyethylene (20) sorbitan 0.5
Behenic acid 1.0
Compound of Synthesis Example 1 1.0
Dipropylene glycol 6.0
Glycerin 10.0

Citric acid 0.3
Fragrance 0.1
Purified water remaining

(Production Example 15) Hair dye Weight%
(First agent)
Sodium citrate 0.8
Aqueous ammonia solution (30%) 5.0

2,5-Diaminotoluene sulfate 5.0
2-Amino-4-nitrophenol 3.0

5-Aminoorthocresol 1.0
p-Aminophenol 1.0
2,6-diaminopyridine 0.1
Hydroxyethyl cellulose 2.5
Oleyl alcohol 5.0
Compound of Synthesis Example 1 0.05
Propylene glycol 2.0
Pantothenyl ethyl ether 0.2
Sodium sulfite 1.0
Edetate tetrasodium 0.2
Monoethanolamine 1.5
Purified water remaining

(Second agent)
Hydrogen peroxide solution (35%) 15.0

Compound of Synthesis Example 2 0.05
1,3-butylene glycol 10.0

Stearyl trimethyl ammonium chloride 0.5
Lactic acid 0.2
Fragrance 0.1
Purified water remaining

(Production Example 16) Hair restorer% by weight
Polyoxypropylene diglyceryl ether 3.0
Polyoxyethylene Polyoxypropylene glycol 2.0
Sodium glutamate 2.0
Ethanol 60.0

Compound of Synthesis Example 2 0.05
Sorbitol 5.0
1,5-pentanediol 4.5
DL-α-tocopherol acetate 1.5
Pepper tincture 0.5
Resorcin 0.5
Dipotassium glycyrrhizinate 0.5
Carboxymethylchitin 0.5
Decamethylcyclopentasiloxane 0.1
Purified water remaining

(Production Example 17) Bath agent weight%
Sodium bicarbonate 60.0

Borax 5.0
Sodium hyaluronate 1.0
Hydroxypropyl methylcellulose 1.0
Fine powder sorbitol 5.0
Compound of Synthesis Example 2 0.5
Fragrance 3.0
Residual amount of sodium sulfate 100

(Production Example 18) Ointment Weight%
l-Menthol 3.0
DL-Camphor 0.5

Compound of Synthesis Example 1 0.2
Propylene glycol 15.0

Carboxyvinyl polymer 1.0
Hydroxyethyl cellulose 0.1
Triethanolamine 0.7
Purified water 25.0

Remaining amount of ethanol 100

(Production Example 19) Patch%
l-Menthol 3.0
DL-Camphor 1.5

Polyacrylic acid 4.5
Sodium polyacrylate 1.5
Sodium carboxymethylcellulose 4.0
Compound of Synthesis Example 1 0.1
Glycerin 20.0

Sorbitol 5.0
Polyoxyethylene nonylphenyl ether 0.5
Kaolin 5.0
Castor oil 1.0
Purified water remaining The above-mentioned components dissolved, dispersed and kneaded were spread on a polyester non-woven fabric so as to be 1000 g per 1 m ² to produce a patch.

IR chart of polylysine containing polyorganosiloxane obtained in Synthesis Example 8

Claims (48)

Following formula (1)

[In the formula (1), V represents the following formula (5)

A repeating unit 1 represented by the following formula (6):

A random copolymer in which the repeating units 2 are irregularly polymerized, an alternating copolymer in which the repeating units 1 and 2 are alternately polymerized, or a block consisting of only the repeating unit 1 and only the repeating unit 2 A block copolymer in which the blocks are combined, the repeating number 1 of the repeating unit 1 is an integer of 0 to 50, the repeating number b of the repeating unit 2 is an integer of 0 to 50, and a + b is an integer of 1 to 50, A ¹ is the following formula (2)
-X-Y-Z (2)
{In Formula (2), X is

(Wherein R ¹ represents a linear or branched alkylene group having 1 to 5 carbon atoms, an alkenylene group having 2 to 5 carbon atoms, or an arylene group having 6 to 10 carbon atoms), and Y represents the number of carbon atoms 1 to 1000 linear or branched alkylene groups, and any methylene group not adjacent to each other in the alkylene group may be substituted with -O- (ether), and Z is represented by the following formula (3) or Following formula (4)

(R ² and R ^{3 in} Formula (3) and Formula (4) are each independently a linear or branched alkyl group having 1 to 20 carbon atoms or an aryl group having 6 to 10 carbon atoms, and c is An integer of 1-1000, d is an integer of 1-1000, and e is an integer of 0-1000. }, A ² and A ³ are each independently an amino group or a group represented by the above formula (2), and when a is 0, both A ² and A ³ are amino groups. Never. ]
A cosmetic composition comprising one or more of the polyorganosiloxane-containing ε-polylysine compound represented by the formula (1) or a physiologically acceptable salt thereof and a polyhydric alcohol. The following formula (6) constituting the polyorganosiloxane-containing ε-polylysine compound

2. The polyorganosiloxane-containing ε-polylysine compound or a physiologically acceptable salt thereof containing a polyorganosiloxane having a repeating number 2 of 5 or more of the repeating unit 2 represented by the formula ( 1 ). Cosmetic composition. The following formula (5) constituting the polyorganosiloxane-containing ε-polylysine compound

The repeating number a of the repeating unit 1 represented by the following formula (6)

In repetition number b of repeating units 2 represented satisfies the 0.1 ≦ b / (a + b ) ≦ 0.98, cosmetic composition according to claim 1 or 2. The following formula (2) constituting the polyorganosiloxane-containing ε-polylysine compound
-X-Y-Z (2)
X of the group represented by

The cosmetic composition according to any one of claims 1 to 3 , which is a group represented by: The following formula (2) constituting the polyorganosiloxane-containing ε-polylysine compound
-X-Y-Z (2)
X of the group represented by

(In X of Formula (2), R ¹ represents a linear or branched alkylene group having 1 to 5 carbon atoms, an alkenylene group having 2 to 5 carbon atoms, or an arylene group having 6 to 10 carbon atoms). The cosmetic composition according to any one of claims 1 to 3 , which is a group to be prepared. The following formula (2) constituting the polyorganosiloxane-containing ε-polylysine compound
-X-Y-Z (2)
X of the group represented by

(In X in Formula (2), R ¹ represents a linear or branched alkylene group having 1 to 5 carbon atoms, an alkenylene group having 2 to 5 carbon atoms, or an arylene group having 6 to 10 carbon atoms.)
The cosmetic composition according to any one of claims 1 to 3 , which is a group represented by: The following formula (2) constituting the polyorganosiloxane-containing ε-polylysine compound
-X-Y-Z (2)
X of the group represented by

The cosmetic composition according to any one of claims 1 to 3 , which is a group represented by: The following formula (2) constituting the polyorganosiloxane-containing ε-polylysine compound
-X-Y-Z (2)
X of the group represented by

The cosmetic composition according to any one of claims 1 to 3 , which is a group represented by: Polyhydric alcohol is 1,3-butylene glycol, glycerin, propylene glycol, polyethylene glycol, dipropylene glycol, 1,2-pentanediol, 1,5-pentanediol, 1,2-hexanediol, 1,6-hexane The cosmetic composition according to any one of claims 1 to 8 , which is one or more selected from the group consisting of diol, mannitol and sorbitol. Polyhydric alcohol is ethanediol, diethylene glycol, triethylene glycol, 2-amino-2-methyl-1,3-propanediol, 1,2-propanediol, 1,3-propanediol, polypropylene glycol, 1,2- Butanediol, 1,3-butanediol, 1,4-butanediol, isopentanediol, pentylene glycol, hexylene glycol, 1,3-pentanediol, 1,4-pentanediol, 1,2,3-pentanetriol 2,3,4-pentanetriol, 1,3,4-pentanetriol, 1,3,5-pentanetriol, 1,3-hexanediol, 1,4-hexanediol, 1,5-hexanediol, 1 , 2,3-hexanetriol, 1,3,4-hexanetriol, 1,3,5-hexanetriol, 1,4,6-hexanetriol, erythritol, pentaerythritol, dipentaerythritol, Itoru, arabitol, xylitol, is ribitol, galactitol, lactitol, maltitol, inositol, panthenol, Raminitoru, valienamine, one or more selected from the group consisting of Baridamin and Baridatoru, according to any one of claims 1-8 Cosmetic composition. The cosmetic composition according to any one of claims 1 to 10 , comprising 0.001 to 20% by weight of a polyorganosiloxane-containing ε-polylysine compound or a physiologically acceptable salt thereof. The cosmetic composition according to any one of claims 1 to 11 , wherein the cosmetic composition is a hair treatment agent. The makeup according to claim 12 , wherein the hair treatment agent is a hair styling agent, a shampoo, a rinse, a treatment, a hair cream, a hair foam, a hair blow, a hair color, a hair dye, a permanent agent, a hair restorer, a hair nourishing agent, or a hair loss inhibitor. Composition. The cosmetic composition according to any one of claims 1 to 11 , wherein the cosmetic composition is a skin care cosmetic. The cosmetic composition according to claim 14 , wherein the skin care cosmetic is a lotion, a cosmetic liquid, a whitening lotion, an emulsion, a whitening emulsion, a cream, a whitening cream, an ointment, a whitening ointment, a lotion, a whitening lotion, an oil or a pack. . The cosmetic composition according to any one of claims 1 to 11 , wherein the cosmetic composition is a makeup cosmetic. The cosmetic composition according to claim 16 , wherein the makeup cosmetic is a foundation, liquid foundation, lipstick, lip gloss, eye shadow, white powder, white powder, blusher, eye shadow, eyeliner, mascara or eyebrow. The cosmetic composition according to any one of claims 1 to 11 , wherein the cosmetic composition is a skin cleanser. The cosmetic composition according to claim 18 , wherein the skin cleanser is soap, cleansing cream, cleansing lotion, cleansing milk, cosmetic composition, facial cleanser or body shampoo. The cosmetic composition according to any one of claims 1 to 11 , wherein the cosmetic composition is a bath preparation. The cosmetic composition according to any one of claims 1 to 11 , wherein the cosmetic composition is a finishing cosmetic. The cosmetic composition according to any one of claims 1 to 11 , wherein the cosmetic composition is a patch.   Cosmetic composition containing polyorganosiloxane-containing ε-polylysine compound obtained by reacting ε-polylysine with polyorganosiloxane or one or more of physiologically acceptable salts thereof and a polyhydric alcohol. object. ε-polylysine is represented by the following formula (7)

The cosmetic composition according to claim 23 , wherein n is an integer of 2 to 51. The cosmetic composition according to claim 23 or 24 , wherein the polyorganosiloxane has a functional group capable of reacting with an amino group of ε-polylysine. Polyorganosiloxane is a polyorganosiloxane having a polyorganosiloxane, the polyorganosiloxane, the polyorganosiloxane or unsaturated group having a halogenated alkyl group having carboxylic acid or carboxylic acid derivative having an epoxy group, claims 23 to The cosmetic composition according to any one of 25 . The polyorganosiloxane has the following formula (8)
QYZ (8)
[Q in Formula (8) is

(Wherein R ⁴ is a linear or branched alkyl group having 1 to 20 carbon atoms, or an aryl group or trimethylsilyl group having 6 to 10 carbon atoms, and R ⁵ is a linear or branched chain having 1 to ⁵ carbon atoms. An alkylene group, an alkenylene group having 2 to 5 carbon atoms, or an arylene group having 6 to 10 carbon atoms, and W is chlorine, bromine, or iodine.) And Y is a straight chain having 1 to 1000 carbon atoms or A branched alkylene group, and any non-adjacent methylene group in the alkylene group may be substituted with —O— (ether), and Z represents the following formula (3) or formula (4):

(R ² and R ^{3 in} Formula (3) and Formula (4) are each independently a linear or branched alkyl group having 1 to 20 carbon atoms or an aryl group having 6 to 10 carbon atoms, and c is An integer of 1-1000, d is an integer of 1-1000, and e is an integer of 0-1000. ]
The cosmetic composition according to any one of claims 23 to 26 , which is a polyorganosiloxane represented by the formula: Polyhydric alcohol is 1,3-butylene glycol, glycerin, propylene glycol, polyethylene glycol, dipropylene glycol, 1,2-pentanediol, 1,5-pentanediol, 1,2-hexanediol, 1,6-hexane The cosmetic composition according to any one of claims 23 to 27 , wherein the cosmetic composition is one or more selected from the group consisting of diol, mannitol and sorbitol. Polyhydric alcohol is ethanediol, diethylene glycol, triethylene glycol, 2-amino-2-methyl-1,3-propanediol, 1,2-propanediol, 1,3-propanediol, polypropylene glycol, 1,2- Butanediol, 1,3-butanediol, 1,4-butanediol, isopentanediol, pentylene glycol, hexylene glycol, 1,3-pentanediol, 1,4-pentanediol, 1,2,3-pentanetriol 2,3,4-pentanetriol, 1,3,4-pentanetriol, 1,3,5-pentanetriol, 1,3-hexanediol, 1,4-hexanediol, 1,5-hexanediol, 1 , 2,3-hexanetriol, 1,3,4-hexanetriol, 1,3,5-hexanetriol, 1,4,6-hexanetriol, erythritol, pentaerythritol, dipentaerythritol, Itoru, arabitol, xylitol, is ribitol, galactitol, lactitol, maltitol, inositol, panthenol, Raminitoru, valienamine, one or more selected from the group consisting of Baridamin and Baridatoru, according to any one of claims 23 to 27 Cosmetic composition. 30. The cosmetic composition according to any one of claims 23 to 29 , wherein the cosmetic composition is a hair treatment agent. The cosmetic according to claim 30 , wherein the hair treatment agent is a hair styling agent, a shampoo, a rinse, a treatment, a hair cream, a hair foam, a hair blow, a hair color, a hair dye, a permanent agent, a hair restorer, a hair nourishing agent, or a hair loss preventing agent. Composition. 30. The cosmetic composition according to any one of claims 23 to 29 , wherein the cosmetic composition is a skin care cosmetic. The cosmetic composition according to claim 32 , wherein the skin care cosmetic is a lotion, a beauty lotion, a whitening lotion, an emulsion, a whitening emulsion, a cream, a whitening cream, an ointment, a whitening ointment, a lotion, a whitening lotion, an oil or a pack. . The cosmetic composition according to any of claims 23 to 29 , wherein the cosmetic composition is a makeup cosmetic. 35. The cosmetic composition according to claim 34 , wherein the makeup cosmetic is a foundation, liquid foundation, lipstick, lip gloss, eye shadow, white powder, white powder, blusher, eye shadow, eyeliner, mascara or eyebrow. 30. The cosmetic composition according to any one of claims 23 to 29 , wherein the cosmetic composition is a skin cleanser. The cosmetic composition according to claim 36 , wherein the skin cleanser is soap, cleansing cream, cleansing lotion, cleansing milk, cosmetic composition, facial cleanser or body shampoo. 30. The cosmetic composition according to any one of claims 23 to 29 , wherein the cosmetic composition is a bath preparation. The cosmetic composition according to any of claims 23 to 29 , wherein the cosmetic composition is a finishing cosmetic. The cosmetic composition according to any one of claims 23 to 29 , wherein the cosmetic composition is a patch.   Cosmetics in which polyorganosiloxane-containing ε-polylysine compound obtained by reacting ε-polylysine with polyorganosiloxane or one or more of its physiologically acceptable salts and polyhydric alcohol are mixed. A method for producing the composition. ε-polylysine is represented by the following formula (7)

42. The method for producing a cosmetic composition according to claim 41 , wherein n is an integer of 2 to 51. The method for producing a cosmetic composition according to claim 41 or 42 , wherein the polyorganosiloxane has a functional group capable of reacting with an amino group of ε-polylysine. Polyorganosiloxane is a polyorganosiloxane having a polyorganosiloxane, the polyorganosiloxane, the polyorganosiloxane or unsaturated group having a halogenated alkyl group having carboxylic acid or carboxylic acid derivative having an epoxy group, claims 41 to 45. A method for producing a cosmetic composition according to any one of 43 . The polyorganosiloxane has the following formula (8)
QYZ (8)
[Q in Formula (8) is

(Wherein R ⁴ is a linear or branched alkyl group having 1 to 20 carbon atoms, or an aryl group or trimethylsilyl group having 6 to 10 carbon atoms, and R ⁵ is a linear or branched chain having 1 to ⁵ carbon atoms. An alkylene group, an alkenylene group having 2 to 5 carbon atoms, or an arylene group having 6 to 10 carbon atoms, and W is chlorine, bromine, or iodine.) And Y is a straight chain having 1 to 1000 carbon atoms or A branched alkylene group, and any non-adjacent methylene group in the alkylene group may be substituted with —O— (ether), and Z represents the following formula (3) or formula (4):

(R ² and R ^{3 in} Formula (3) and Formula (4) are each independently a linear or branched alkyl group having 1 to 20 carbon atoms or an aryl group having 6 to 10 carbon atoms, and c is An integer of 1-1000, d is an integer of 1-1000, and e is an integer of 0-1000. ]
The manufacturing method of the cosmetic composition in any one of Claims 41-44 which is polyorganosiloxane represented by these. The polyorganosiloxane-containing ε-polylysine compound has the following formula (1):

[In the formula (1), V represents the following formula (5)

A repeating unit 1 represented by the following formula (6):

A random copolymer in which the repeating units 2 are irregularly polymerized, an alternating copolymer in which the repeating units 1 and 2 are alternately polymerized, or a block consisting of only the repeating unit 1 and only the repeating unit 2 A block copolymer in which the blocks are combined, the repeating number 1 of the repeating unit 1 is an integer of 0 to 50, the repeating number b of the repeating unit 2 is an integer of 0 to 50, and a + b is an integer of 1 to 50, A ¹ is the following formula (2)
-X-Y-Z (2)
{In Formula (2), X is

(Wherein R ¹ represents a linear or branched alkylene group having 1 to 5 carbon atoms, an alkenylene group having 2 to 5 carbon atoms, or an arylene group having 6 to 10 carbon atoms), and Y represents the number of carbon atoms 1 to 1000 linear or branched alkylene groups, and any methylene group not adjacent to each other in the alkylene group may be substituted with -O- (ether), and Z is represented by the following formula (3) or Following formula (4)

(R ² and R ^{3 in} Formula (3) and Formula (4) are each independently a linear or branched alkyl group having 1 to 20 carbon atoms or an aryl group having 6 to 10 carbon atoms, and c is An integer of 1-1000, d is an integer of 1-1000, and e is an integer of 0-1000. }, A ² and A ³ are each independently an amino group or a group represented by the above formula (2), and when a is 0, both A ² and A ³ are amino groups. Never. ]
The manufacturing method of the cosmetic composition in any one of Claims 41-45 represented by these. Polyhydric alcohol is 1,3-butylene glycol, glycerin, propylene glycol, polyethylene glycol, dipropylene glycol, 1,2-pentanediol, 1,5-pentanediol, 1,2-hexanediol, 1,6-hexane The method for producing a cosmetic composition according to any one of claims 41 to 46 , wherein the cosmetic composition is one or more selected from the group consisting of diol, mannitol and sorbitol. Polyhydric alcohol is ethanediol, diethylene glycol, triethylene glycol, 2-amino-2-methyl-1,3-propanediol, 1,2-propanediol, 1,3-propanediol, polypropylene glycol, 1,2- Butanediol, 1,3-butanediol, 1,4-butanediol, isopentanediol, pentylene glycol, hexylene glycol, 1,3-pentanediol, 1,4-pentanediol, 1,2,3-pentanetriol 2,3,4-pentanetriol, 1,3,4-pentanetriol, 1,3,5-pentanetriol, 1,3-hexanediol, 1,4-hexanediol, 1,5-hexanediol, 1 , 2,3-hexanetriol, 1,3,4-hexanetriol, 1,3,5-hexanetriol, 1,4,6-hexanetriol, erythritol, pentaerythritol, dipentaerythritol, Itoru, arabitol, xylitol, ribitol, galactitol, lactitol, maltitol, inositol, panthenol, Raminitoru, valienamine, is one or more selected from the group consisting of Baridamin and Baridatoru, according to any one of claims 41 to 46 A method for producing a cosmetic composition.

Images