JP4874686B2 - Anti-wrinkle / improving agent - Google Patents

Description

  The present invention relates to a wrinkle prevention / improving agent excellent in safety and having an effect of suppressing the generation of wrinkles on the skin and improving the generated wrinkles.

  Aging is progressing in the organs of the whole body, but among the skin that can be seen with eyes, especially on the face where the consciousness is particularly concentrated, wrinkles and fine wrinkles that occur with aging are many middle-aged people in the world, Especially annoying women. Conventionally, the necessity of a wrinkle-improving cosmetic material has been screamed, but since there are many parts that are not clear about the mechanisms related to aging and wrinkles, in conventional cosmetics, biochemical products such as mucopolysaccharides and collagen and They have only selected a method of blending synthetic polymer products and trying to retain moisture to improve wrinkles.

  However, the above method alone cannot sufficiently prevent skin aging and wrinkles. In recent years, research on aging has been promoted, and aging is an important factor as a cause of skin aging, and dryness, oxidation, sunlight (ultraviolet rays), etc. are also cited as direct factors related to skin aging. It has been. Among these factors, it has become clear that sunlight (ultraviolet rays) plays an important role in a change called photoaging. The face described above is the most prone to photoaging in the whole body, but it is also clear that collagen fibers, which are the main matrix components of the dermis, are markedly reduced in photoaged skin. I came. It has also been suggested that phenomena such as the generation of wrinkles and fine lines and the disappearance of tension are closely related to the decrease in collagen fibers. Thus, with regard to wrinkle generation and skin aging, the proliferation activity of fibroblasts, which are the main cells in the dermis, and the synthetic functions of collagen, etc., decrease with exposure to various skin aging factors, especially sunlight (ultraviolet rays). And the turnover speed of this collagen etc. also becomes slow. As a result, the elasticity of the skin is lost, wrinkles are generated, and skin aging progresses.

  Regarding substances having wrinkle improving effects, it has been known that alanine and glycine, which are types of amino acids, are effective (see Patent Document 1 and Patent Document 2). However, when these alanine and glycine are applied to the skin, they are very painful and difficult to use.

  The 3- (cyclohexylamino) propanesulfonic acid according to the present invention is described as one of the components of the biologically used Good buffer (see Non-Patent Document 1), and is used for pore reduction. (See Patent Document 3) is known, but it has a novel effect of preventing and improving wrinkles.

  In addition, 3- (cyclohexylamino) -2-hydroxypropanesulfonic acid according to the present invention is also known as one of biologically used buffers (see Patent Documents 4 and 5), and pores. The use of the reduction effect (see Patent Document 3) is known. However, it has a novel effect of preventing and improving wrinkles.

JP 11-49628 A JP-A-8-99862 JP 2005-179343 A US Pat. No. 4,169,950 US Pat. No. 4,246,194 E. Good, Biochemistry, 5 (2), p. 467, 1966

  The present invention has been made in view of the above circumstances, and an object thereof is to provide a safe wrinkle prevention / improving agent that is excellent in the effect of suppressing the generation of wrinkles or the effect of improving wrinkles.

  As a result of intensive studies to solve the above problems, the present inventors have found that a specific aminosulfuric acid compound and a salt thereof have an effect of preventing and improving excellent wrinkles, and are a safe substance. The present inventors have found that the above problems can be solved, and have completed the present invention.

  That is, the present invention is a wrinkle prevention / improving agent containing one or more compounds selected from the group consisting of aminosulfuric acid compounds represented by the following general formula (1) and salts thereof.

(In general formula (1), R ₁ represents a hydrogen atom or a hydroxyl group.)

  According to the present invention, a wrinkle prevention / improving agent having an excellent wrinkle prevention / improvement effect can be obtained.

  Hereinafter, the best mode for carrying out the present invention will be described in detail.

  In the present invention, one or more compounds selected from the group consisting of aminosulfuric acid compounds represented by the following general formula (1) and salts thereof are used.

(In general formula (1), R ₁ represents a hydrogen atom or a hydroxyl group.)

In the aminosulfuric acid compound represented by the general formula (1), when R ₁ is a hydrogen atom, it is 3- (cyclohexylamino) propanesulfonic acid, which is a known compound generally known by the name of CAPS. When R ₁ is a hydroxyl group, it is 3- (cyclohexylamino) -2-hydroxypropanesulfonic acid, and is a known compound generally known by the name of CAPSO. The aminosulfuric acid compound represented by the general formula (1) used in the present invention can be synthesized by a known method, and is commercially available from Sigma or the like, and can be used.

  The salt of the aminosulfuric acid compound represented by the general formula (1) is not particularly limited, but examples of the inorganic salt include hydrochloride, sulfate, phosphate, hydrobromide, sodium salt, and potassium salt. , Magnesium salt, calcium salt, ammonium salt and the like. Organic salts include acetate, lactate, maleate, fumarate, tartrate, citrate, methanesulfonate, p-toluenesulfonate, triethanolamine salt, diethanolamine salt, amino acid salt, etc. Can be mentioned. The salt can be obtained by a known method.

  The aminosulfuric acid compound represented by the general formula (1) and the salt thereof according to the present invention have excellent wrinkle prevention / improvement effects as will be proved later. Therefore, it contains one or more compounds selected from the group consisting of the aminosulfuric acid compound represented by the general formula (1) and a salt thereof, and is prepared as a wrinkle prevention / improving agent.

  The wrinkle prevention / improving agent is a new and useful application based on the discovery of the novel function of the aminosulfuric acid compound represented by the general formula (1) and the salt thereof according to the present invention.

  In the wrinkle prevention / improving agent, one or more compounds selected from the group consisting of the aminosulfuric acid compound represented by the general formula (1) and a salt thereof are effective in exhibiting the wrinkle prevention / amelioration action. However, the content is preferably 0.001 to 20.0% by mass in the total amount of the wrinkle prevention / improving agent. More preferably, it is 0.1-10.0 mass%.

  The wrinkle prevention / improving agent according to the present invention can be produced according to a conventional method, and as a component constituting the wrinkle prevention / improving agent, a group consisting of the aminosulfuric acid compound represented by the general formula (1) and salts thereof One or two or more of the compounds selected from the above can be prepared alone, but other than those usually used for skin external preparations such as cosmetics and pharmaceuticals including quasi-drugs, as long as the effects of the present invention are not impaired. The components can be appropriately blended as necessary. Examples of the other components (optional blending components) include oils, surfactants, powders, coloring materials, water, alcohols, silicones, thickeners, chelating agents, antioxidants, ultraviolet absorbers, and humectants. , Fragrances, various medicinal ingredients, preservatives, pH adjusters, neutralizers and the like.

  The wrinkle prevention / improving agent is used in the form of cosmetics, pharmaceutical compositions, etc., and exhibits an excellent wrinkle prevention / improvement effect. In particular, it is preferably applied to cosmetics, pharmaceuticals, etc., and is used in a form of an external preparation for skin that is externally applied to the skin.

The wrinkle prevention / improving agent of the present invention can be applied to the skin to prevent wrinkle formation and / or reduce or eliminate wrinkles formed. The usage and dosage of the wrinkle prevention / improving agent of the present invention in such a cosmetic method is not particularly limited and is appropriately determined depending on the dosage form and the state of wrinkles on the skin to be treated. Applicable amount, for example, 1 to 5 times, for example, 0.1 ml to 1 ml per 1 cm ² , can be directly rubbed into the skin, or the appropriate amount can be soaked in gauze or the like and applied to the skin.

  The dosage form of the wrinkle prevention / improving agent is not particularly limited as long as it can exert the effects of the present invention, and examples thereof include a solution system, a solubilization system, an emulsification system, a powder dispersion system, and a water-oil two-layer system. , Water-oil-powder three-layer system, ointment, gel, aerosol, etc.

  The wrinkle prevention / improving agent is applied, for example, in the field of cosmetics including quasi-drugs and pharmaceuticals, and the product forms include, for example, ointments, creams, emulsions, lotions, essences, jellies, gels, packs, Arbitrary forms such as a mask and a foundation can be taken.

  The present invention will be specifically described with reference to examples, but the technical scope of the present invention is not limited to these examples. The blending amount is mass% unless otherwise specified.

[Wrinkle improvement test with hairless mice]
As a mouse, an Hr-1 (Skh-1) hairless mouse (Hoshino experimental animal; 6 weeks to 10 weeks old) was used, and the method of Schwartz et al. (Haratake A. et al. J. Invest. Dermatol. 108: 769-775). , 1997.), a method of repeated irradiation with UVB (Naganuma M. et al. J. Dermatol. Sci. 25: 29-35, 2001. Schwartz EJ Invest. Dermatol. 91: 158-161, 1988 .) Wrinkles were formed. That is, the back was irradiated with UVB (light source; Toshiba FL-20 SE fluorescent lamp manufactured by Toshiba Electric) three times a week for 10 weeks. Irradiation amount after the start of the 36mJ / cm ² / times, 2 weeks later is gradually increased, 10 weeks was 216mJ / cm ² / times. The total irradiation dose was 4.6 J / cm ² . The amount of ultraviolet rays used was a value measured with UVRADIOMETER (UVR-305 / 365D (II), Topcon). After UV irradiation was completed, a photo of the back of the mouse was taken, and the degree of wrinkle formation was determined using a method that partially modified Biset et al.'S method (Bissett DL. Et al. Photochemistry and Photobiology 46: 367-378, 1987). The following solutions were applied using only mice that were scored according to the criteria shown in Table 1 and formed wrinkles with a score of 7 or higher. The wrinkle scoring work was done individually by three measurers, and the score was determined by discussion.

  The hairless mice having a score of 7 or more were divided into 2 groups of 5 each so that the scores of both groups were the same, and the composition of Comparative Example 1 or Example 1 showing the following composition on the entire back skin of each group of mice 100 μl of each composition was applied once a day, 5 times a week for 6 weeks continuously.

[Example 1] Composition component Amount (% by mass)
CAPSO 1.0
Ethanol for cosmetics 30.0
Purified water residue

[Comparative Example 1] Composition component amount (% by mass)
Ethanol for cosmetics 30.0
Purified water residue

  After the application, a photograph of the back of the mouse was taken, and according to the criteria shown in Table 1 above, the three measurers scored the degree of wrinkles individually with the group name of the animal lying down, and scored by discussion. Were determined.

The degree of improvement of the wrinkle of the mouse was determined as follows. That is,
“Wrinkle improvement” = “Score before solution application” − “Score after 6 weeks of solution application”
It was calculated by the following formula. FIG. 1 shows the degree of wrinkle improvement (wrinkle improvement change amount) obtained according to the above formula. In FIG. 1, A is the composition of Example 1 (with CAPSO), and V is the composition of Comparative Example 1 (with no drug).

  As is apparent from FIG. 1, the composition application group (average score: 3) of Example 1 (CAPSO) of the present invention is compared to the composition application group (average score: 2.4) of Comparative Example 1 (no drug blended). .4) markedly promoted wrinkle reduction. From the above, it was confirmed that the CAPSO solution is effective in improving wrinkles on the skin formed by ultraviolet rays.

[Human wrinkle improvement effect test]
(Test method)
About the wrinkle and fine wrinkle improvement effect of the composition (cream) of Examples 2-9 which show a composition below and Comparative Example 2, it implemented as follows. There are 180 female subjects with many wrinkles in their 40s and 60s, divided into 20 groups per group and 9 groups. Each of the 9 compositions (creams) of the above examples and comparative examples is applied to the 20 eyes of each group. Used continuously for 2 months. After continuous use, a cosmetic engineer evaluated wrinkles and fine wrinkles, and evaluated in four stages: marked, effective, slightly effective, and ineffective, and judged wrinkle improvement effect according to the following criteria.

Remarkable: Wrinkles and fine lines are almost inconspicuous.
Effective: Wrinkles and fine lines became inconspicuous.
Slightly effective: Wrinkles and fine lines became less noticeable than before the test.
Invalid: No change.

(Judgment)
Excellent: 80% or more of subjects exhibiting remarkable, effective, and slightly effective.
Good: The proportion of subjects showing remarkable, effective and slightly effective is 50% or more and less than 80%.
Acceptable: The proportion of subjects who are markedly effective, effective and slightly effective is 30% or more and less than 50%.
Impossible: The proportion of subjects showing remarkable, effective and slightly effective is less than 30%.

Examples 2 to 9 and Comparative Example 2 Composition (Cream)
Ingredient Amount (% by mass)
A (oil phase)
Squalane 15.0
Vaseline 7.0
Cetanol 4.0
Isopropyl myristate 8.0
Stearic acid monoglycerin ester 2.0
POE (20) sorbitan monostearate 2.0
Vitamin E acetate 1.0
Ethylparaben 0.2
Fragrance 0.2
B (water phase)
Glycerin 4.0
Dipropylene glycol 4.0
Wrinkle prevention / improving agent (described in Table 2 below) Sodium lactate described in Table 2 2.0
Edetate trisodium 0.01
Potassium hydroxide 0.2
Purified water residue

(Production Method) A (oil phase) and B (aqueous phase) were each heated to 70 ° C. and completely dissolved. A was added to B and emulsified with an emulsifier. The emulsion was cooled using a heat exchanger to produce a composition (cream).

(Test results)
The test results are shown in Table 3.

  As is clear from Table 3, it can be seen that the compositions (creams) of Examples 2 to 9 according to the present invention have an excellent wrinkle improving effect.

  The following is an external preparation for skin as a preparation example of the wrinkle prevention / improving agent according to the present invention. All of the external preparations for skin had excellent wrinkle prevention and improvement effects.

Formulation Example 1: Wrinkle prevention / improvement cream ingredient content (% by mass)
Stearic acid 5.0
Stearyl alcohol 4.0
Isopropyl myristate 18.0
Glycerol monostearate 3.0
Propylene glycol 10.0
CAPSO 20.0
Caustic potash 0.2
Sodium bisulfite 0.01
Preservative Appropriate amount of perfume Appropriate amount of ion-exchanged water

(Production method) Propylene glycol and caustic potash were added to ion-exchanged water, dissolved, heated and maintained at 70 ° C (water phase). The other ingredients were mixed, heated and melted, and kept at 70 ° C. (oil phase). The oil phase was gradually added to the aqueous phase, and after the addition was completed, the temperature was maintained for a while to cause the reaction. Thereafter, the mixture was uniformly emulsified with a homomixer and cooled to 30 ° C. while stirring well.

Formulation Example 2: Wrinkle prevention / improvement cream component Amount (% by mass)
Stearic acid 6.0
Sorbitan monostearate ester 2.0
Polyoxyethylene (20 mol)
Sorbitan monostearate 1.5
Propylene glycol 10.0
CAPS 7.0
Glycerin trioctanoate 10.0
Squalene 5.0
Sodium bisulfite 0.01
Ethylparaben 0.3
Perfume Appropriate amount of ion-exchanged water

(Production method) Propylene glycol is added to ion-exchanged water, dissolved, heated and maintained at 70 ° C (aqueous phase). The other ingredients were mixed, heated and melted, and kept at 70 ° C. (oil phase). The oil phase was added to the aqueous phase, pre-emulsified, and uniformly emulsified with a homomixer, and then cooled to 30 ° C. while stirring well.

Formulation Example 3: Wrinkle prevention / improvement cream component Amount (mass%)
Stearyl alcohol 7.0
Stearic acid 2.0
Hydrogenated Lanolin 2.0
Squalane 5.0
2-Octyldodecyl alcohol 6.0
Polyoxyethylene (25 mol) cetyl alcohol ether 3.0
Glycerin monostearate ester 2.0
Propylene glycol 5.0
CAPSO 0.001
Perfume proper amount Sodium bisulfite 0.03
Ethylparaben 0.3
Ion exchange water

(Manufacturing method) Propylene glycol was added to ion-exchanged water, dissolved, heated and maintained at 70 ° C (aqueous phase). The other ingredients were mixed, heated and melted, and kept at 70 ° C. (oil phase). The oil phase was added to the aqueous phase, preliminarily emulsified, and uniformly emulsified with a homomixer, and then cooled to 30 ° C. while stirring well.

Formulation Example 4: Wrinkle prevention / improvement emulsion component content (% by mass)
Stearic acid 2.5
Cetyl alcohol 1.5
Vaseline 5.0
Liquid paraffin 10.0
Polyoxyethylene (10 mol) monooleate 2.0
Polyethylene glycol 1500 3.0
Triethanolamine 1.0
CAPS 10.0
Sodium bisulfite 0.01
Ethylparaben 0.3
Carboxyvinyl polymer 0.05
Perfume Appropriate amount of ion-exchanged water

(Production method) A carboxyvinyl polymer was dissolved in a small amount of ion-exchanged water (phase A). Polyethylene glycol 1500 and triethanolamine were added to the remaining ion-exchanged water, dissolved by heating and kept at 70 ° C. (aqueous phase). The other ingredients were mixed, heated and melted, and kept at 70 ° C. (oil phase). The oil phase was added to the aqueous phase for preliminary emulsification, and the A phase was added, and the mixture was uniformly emulsified with a homomixer.

Formulation Example 5: Wrinkle prevention / improvement emulsion component content (% by mass)
(Oil phase)
Stearyl alcohol 1.5
Squalene 2.0
Vaseline 2.5
Deodorized liquid lanolin 1.5
Evening primrose oil 2.0
Isopropyl myristate 5.0
Glycerol monooleate 2.0
Polyoxyethylene (60 mol) hydrogenated castor oil 2.0
Tocopherol acetate 0.05
Ethylparaben 0.2
Butylparaben 0.1
Ethylglycine 1.0
CAPSO 1.0
Perfume appropriate amount (water phase part)
Sodium bisulfite 0.01
Glycerin 5.0
Sodium hyaluronate 0.01
Carboxyvinyl polymer 0.2
Potassium hydroxide 0.2
Purified water residue

(Manufacturing method) The oil phase part was melt | dissolved at 70 degreeC. The water phase part was dissolved at 70 ° C., the oil phase part was mixed with the water phase part, emulsified with an emulsifier and then cooled to 30 ° C. with a heat exchanger.

Formulation Example 6: Wrinkle prevention / improvement jelly component content (mass%)
95% ethyl alcohol 10.0
Dipropylene glycol 15.0
Polyoxyethylene (50 mol) oleyl alcohol ether 2.0
Carboxyvinyl polymer 1.0
Caustic soda 0.15
L-Arginine 0.1
CAPS 1.0
Methylparaben 0.2
Perfume Appropriate amount of ion-exchanged water

(Production Method) Carboxyvinyl polymer was uniformly dissolved in ion-exchanged water, while sarcosine and polyoxyethylene (50 mol) oleyl alcohol ether were dissolved in 95% ethanol and added to the aqueous phase. Subsequently, other components were added, and the mixture was neutralized with caustic soda and L-arginine to increase the viscosity.

Formulation Example 7: Essence ingredient for wrinkle prevention / improvement Blending amount (% by mass)
(Phase A)
Ethanol (95%) 10.0
Polyoxyethylene (20 mol) octyldodecanol 1.0
Methylparaben 0.15
Pantotenyl ethyl ether 0.1
CAPS 0.05
(Phase B)
Potassium hydroxide 0.1
(Phase C)
Glycerin 5.0
Dipropylene glycol 10.0
Sodium bisulfite 0.03
Carboxyvinyl polymer 0.2
Purified water residue

(Manufacturing method) The A phase and the C phase were uniformly dissolved, and the A phase was added to the C phase and solubilized. Subsequently, after adding B phase, it filled and manufactured.

Formulation Example 8: Wrinkle prevention / improvement pack component Amount (% by mass)
(Phase A)
Dipropylene glycol 5.0
Polyoxyethylene (60 mol) hydrogenated castor oil 5.0
(Phase B)
CAPS 1.0
Olive oil 5.0
Tocophenol acetate 0.2
Ethylparaben 0.2
Fragrance 0.2
(Phase C)
Sodium bisulfite 0.03
Polyvinyl alcohol (degree of saponification 90, degree of polymerization 2000) 13.0
Ethanol 7.0
Purified water residue

(Manufacturing method) A phase, B phase, and C phase were each dissolved uniformly, and B phase was added to A phase to solubilize. Subsequently, after adding this to the C phase, it filled and manufactured.

Formulation Example 9: Ointment component for preventing and improving wrinkles
Polyoxyethylene (30 mol) cetyl ether 2.0
Glycerol monostearate 10.0
Liquid paraffin 10.0
Vaseline 40.0
Cetanol 6.0
Methylparaben 0.1
Butylparaben 0.1
Glycerin monostearate ester 2.0
CAPS 5.0
CAPSO 5.0
Propylene glycol 10.0
Ion exchange water Residual perfume appropriate amount

(Production Method) Propylene glycol was added to ion-exchanged water, dissolved, heated and kept at 70 ° C. (aqueous phase). Other components were mixed and dissolved at 70 ° C. (oil phase). An oil phase was added to the aqueous phase, and the mixture was uniformly emulsified with a homomixer, and filled after cooling.

  Thereafter, creams were produced in the same manner.

Formulation Example 10: Cream component for wrinkle prevention / improvement Compounding amount (% by mass)
Liquid paraffin 8.0
Vaseline 3.0
Dimethylpolysiloxane 2.0
Stearyl alcohol 3.0
Behenyl alcohol 2.0
Glycerin 5.0
Dipropylene glycol 4.0
Trehalose 1.0
Tetra-2-ethylhexanoic acid pentaerythrit 4.0
Polyisoethylene glyceryl monoisostearate 2.0
Polyoxyethylene glycerol monostearate 1.0
Lipophilic glyceryl monostearate 2.0
Citric acid 0.05
Sodium citrate 0.05
Potassium hydroxide 0.015
Oil-soluble licorice extract 0.1
Retinol palmitate (1 million units) 0.25
CAPS 1.0
CAPSO 1.0
Tocopherol acetate 0.1
P-Hydroxybenzoate appropriate amount phenoxyethanol appropriate amount dibutylhydroxytoluene appropriate amount edetate trisodium 0.05
4-t-butyl-4′-methoxydibenzoylmethane 0.01
2-Ethylhexyl paramethoxycinnamate 0.1
β-carotene 0.01
Polyvinyl alcohol 0.5
Hydroxyethyl cellulose 0.5
Carboxyvinyl polymer 0.05
Purified water Residual fragrance Appropriate amount

Formulation Example 11 Wrinkle prevention / improvement cream ingredient blending amount (mass%)
Vaseline 2.0
Dimethylpolysiloxane 2.0
Ethanol 5.0
Behenyl alcohol 0.5
Batyl alcohol 0.2
Glycerin 7.0
1,3-butylene glycol 5.0
Polyethylene glycol 20000 0.5
Jojoba oil 3.0
Squalane 2.0
Phytosteryl hydroxystearate 0.5
Tetra-2-ethylhexanoic acid pentaerythrit 1.0
Polyoxyethylene hydrogenated castor oil 1.0
Potassium hydroxide 0.1
Sodium pyrosulfite 0.01
Sodium hexametaphosphate 0.05
Stearyl glycyrrhetinate 0.1
Pantothenyl ethyl ether 0.1
Arbutin 7.0
Tranexamic acid methylamide hydrochloride 11.0
CAPSO 1.0
Tocopherol acetate 0.1
Sodium hyaluronate 0.05
P-Hydroxybenzoate appropriate amount trisodium edetate 0.05
4-t-butyl-4'-methoxydibenzoylmethane 0.1
Diparamethoxycinnamic acid mono-2-ethylhexanoate glyceryl 0.1
Yellow iron oxide xanthane gum 0.1
Carboxyvinyl polymer 0.2
Purified water residue

Formulation Example 12: Cream component for wrinkle prevention / improvement Blending amount (% by mass)
Vaseline 2.0
Dimethylpolysiloxane 2.0
Ethanol 5.0
Behenyl alcohol 0.5
Batyl alcohol 0.2
Glycerin 7.0
1,3-butylene glycol 5.0
Polyethylene glycol 20000 0.5
Jojoba oil 3.0
Squalane 2.0
Phytosteryl hydroxystearate 0.5
Tetra-2-ethylhexanoic acid pentaerythrit 1.0
Polyoxyethylene hydrogenated castor oil 1.0
Potassium hydroxide 0.1
Sodium pyrosulfite 0.01
Sodium hexametaphosphate 0.05
Stearyl glycyrrhetinate 0.1
Pantothenyl ethyl ether 0.1
Arbutin 7.0
Tranexamic acid methylamide hydrochloride 11.0
CAPS 1.0
Tocopherol acetate 0.1
Sodium hyaluronate 0.05
P-Hydroxybenzoate appropriate amount trisodium edetate 0.05
4-t-butyl-4'-methoxydibenzoylmethane 0.1
Diparamethoxycinnamic acid mono-2-ethylhexanoate glyceryl 0.1
Yellow iron oxide xanthane gum 0.1
Carboxyvinyl polymer 0.2
Purified water residue

Formulation Example 13: Cream component for wrinkle prevention / improvement Blending amount (% by mass)
Vaseline 2.0
Dimethylpolysiloxane 2.0
Ethanol 5.0
Behenyl alcohol 0.5
Batyl alcohol 0.2
Glycerin 7.0
1,3-butylene glycol 5.0
Polyethylene glycol 20000 0.5
Jojoba oil 3.0
Squalane 2.0
Phytosteryl hydroxystearate 0.5
Tetra-2-ethylhexanoic acid pentaerythrit 1.0
Polyoxyethylene hydrogenated castor oil 1.0
Potassium hydroxide 0.1
Sodium pyrosulfite 0.01
Sodium hexametaphosphate 0.05
Stearyl glycyrrhetinate 0.1
Pantothenyl ethyl ether 0.1
Arbutin 7.0
Tranexamic acid methylamide hydrochloride 11.0
CAPSO sodium 1.0
Tocopherol acetate 0.1
Sodium hyaluronate 0.05
P-Hydroxybenzoate appropriate amount trisodium edetate 0.05
4-t-butyl-4'-methoxydibenzoylmethane 0.1
Diparamethoxycinnamic acid mono-2-ethylhexanoate glyceryl 0.1
Yellow iron oxide xanthane gum 0.1
Carboxyvinyl polymer 0.2
Purified water residue

  All the wrinkle prevention / improving agents produced in Formulation Examples 1 to 13 showed wrinkle improvement effects in the same tests as in Examples 2 to 9.

It is a figure which shows the wrinkle improvement degree test result by CAPSO application | coating.

Claims (1)

A wrinkle prevention / improving agent containing one or more compounds selected from the group consisting of aminosulfuric acid compounds represented by the following general formula (1) and salts thereof.

(In general formula (1), R ₁ represents a hydrogen atom or a hydroxyl group.)

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