JP4879390B2 - Temperature control method for frozen liquid samples - Google Patents
Temperature control method for frozen liquid samples Download PDFInfo
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- JP4879390B2 JP4879390B2 JP2000286308A JP2000286308A JP4879390B2 JP 4879390 B2 JP4879390 B2 JP 4879390B2 JP 2000286308 A JP2000286308 A JP 2000286308A JP 2000286308 A JP2000286308 A JP 2000286308A JP 4879390 B2 JP4879390 B2 JP 4879390B2
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02W—CLIMATE CHANGE MITIGATION TECHNOLOGIES RELATED TO WASTEWATER TREATMENT OR WASTE MANAGEMENT
- Y02W30/00—Technologies for solid waste management
- Y02W30/50—Reuse, recycling or recovery technologies
- Y02W30/80—Packaging reuse or recycling, e.g. of multilayer packaging
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Description
【０００１】
【発明の属する技術分野】
本発明は、液状臨床検査用試薬やその原料となる液状試料を凍結した凍結液状試料を輸送ケースに保存して配送する際の温度管理方法に関する。
【０００２】
【従来の技術】
液状臨床検査用試薬やその原料となる液状試料を凍結した凍結液状試料は、その品質保持のために、一度融解したものを再凍結するのを禁止している。そのため、凍結液状試料は小型の発泡スチロール製の箱に大量のドライアイス詰めて配送されていた。しかし、配送は通常一日から数日を要し、配送時間が長くなると特に夏場はドライアイスの消耗が激しく温度管理が十分でないことも生じ得るという問題があった。
【０００３】
配送の途中で凍結試料が何らかの原因により温度変化を受けても、その後の配送条件で試料が凍結状態で顧客に配送された場合には、商品を受け取った時点では試料の劣化が確認できないという問題があった。さらに、凍結試料を用いて測定値に異常が生じた場合でも、配送途中に試薬について温度管理上の問題が生じたのか、測定を行った者の技術的な問題によるものかを特定することが困難であった。
【０００４】
さらに、発泡スチロール製を用いた場合には、温度維持のために大量のドライアイスを要し、経済的にも環境上も好ましい状態ではなかった。
【０００５】
【発明が解決しようとする課題】
本発明の課題は、液状臨床検査用試薬やその原料となる液状試料を凍結した凍結液状試料が、その配送途上において指定温度から外れた温度に所定時間以上暴露されたか否かを確認可能な凍結液状試料の温度管理方法を提供することである。
【０００６】
【課題を解決するための手段】
本発明は、
１．配送のための温度保持機能を有する輸送ケース内に保存された凍結液状試料の温度管理方法であって、凍結液状試料が液状臨床検査用試薬を凍結したもの又はその原料となる液状試料を凍結したものであり、凍結液状試料と同梱され、輸送ケース内の温度が指定温度より上昇すると、その持続時間により複数段階で着色変化をおこし、配送途上での温度変化の管理を可能にする温度インジケーターを用いて、凍結液状試料が指定温度から外れた温度に所定時間以上暴露されたか否かを確認可能であることを特徴とする凍結液状試料の温度管理方法、
２．指定温度が−１８℃であることを特徴とする前項１に記載の凍結液状試料の温度管理方法、
３．輸送ケースの開梱時に、凍結液状試料が指定温度保証されていることを温度インジケーターにより確認可能であることを特徴とする前項１または２に記載の凍結液状試料の温度管理方法、
４．輸送ケースを再利用することを特徴とする前項１から３のいずれか１に記載の凍結液状試料の温度管理方法。
５．輸送ケースがジャーであることを特徴とする前項１から４のいずれか１に記載の凍結液状試料の温度管理方法、
からなる。
【０００７】
【発明の実施の形態】
通函方式の商品配送サービス方法とは、所謂通い箱方式であって、顧客からの商品配送要求に際して輸送ケースに対象製品を保管して、目的の顧客に対して商品を配送し、配送完了後少なくとも輸送ケースを回収することからなる商品配送サービス方法をいう。さらに、目的に応じて外箱として用いられるダンボールケース／または発泡スチロールケースを回収しても良い。
【０００８】
好ましい態様として、凍結液状試料をドライアイスおよび温度インジケーターとともに輸送ケースに詰め、さらに保温性が必要な場合には例えば発泡スチロール等に入れて配送することが挙げられる。温度インジケーターを凍結液状試料と一緒に詰めることにより、当該試料が融解後再凍結したものでないことを示す指標となり、信頼性の高い試料を提供することができる。
【０００９】
さらに、配送者が顧客に商品を引き渡す際に、配送者および／または顧客が開梱し、その場で温度インジケーターを確認することにより、試料が指定温度保証されていることを確認することができる。
【００１０】
本発明において配送される商品は凍結液状の試料であり、一度融解したものを再凍結するのを禁止しているものが挙げられる。このような凍結液状試料として、臨床検査用試薬、酵素製品、またはそれらの原料となる試料等が例示される。さらに、これらには試験管理試料や検量用試料が例示され、これらに含まれる物質としては具体的に酵素（AST,ALT,LD-1,CK,ALP,AMY,P-AMY,LAP,γ-GT,CHE等）、脂質（TG,T-CHO,F-CHO,PL等）、蛋白質（TP,ALB,CRP等）、非蛋白性窒素成分（UN,CRE,UA等）、無機質（Ca,Mg,IP,Fe,Na,K,Cl等）、糖質（GLU,SA等）、生体色素（T-BIL,D-BIL等）が好適に例示される。
【００１１】
本発明において試料・商品は、凍結状態にある。保存温度は摂氏零度以下が維持可能な状態におかれる。特に好ましい保存温度は−１８℃以下である。輸送ケース器内の低温維持のためには好適にはドライアイスが使用される
【００１２】
本発明において試料・商品は、再使用可能な温度保持機能を担持する輸送ケース内に保存される。このような輸送ケースとしては、例えば発泡スチロールや温度保持機能を担持したジャー、俗称魔法瓶等が例示される。好ましくは、温度保持機能を有するジャーを利用することにより、使用するドライアイスの量を削減することができ、経済的である。
【００１３】
本発明において試料・商品は、凍結液状試料の配送途上における試料の指定温度保証を担保可能にする。つまり、温度上昇により配送途上で配送指定温度以上の状況に試料・商品がさらされると、その履歴について顧客が試料・商品受領時に一目瞭然と判別可能なる。さらに、本発明は配送者が顧客に商品を引き渡す際に、顧客立会いのもとで開梱し、その場で温度インジケーターを確認することにより、試料が指定温度保証されていることを確認する商品配送サービスを提供することにより、例えば変性してしまい、または規格外になってしまった可能性の高い試料を顧客が受け取ってしまうことのリスクを排除可能とする。
【００１４】
この保証のために本発明の方法は、配送途上での温度変化の管理を可能にする温度インジケーターを採用した。該温度インジケーターは、指定温度から外れた温度に暴露された時間経過の程度によって、複数のレベル表示を可能とする。例えば、−１８℃以上に３時間程度のさらされたのであれば注意信号、それ以上であれば危険信号というように判別可能とする。
【００１５】
本発明は配送者が顧客に商品を引き渡した後、そのまま輸送ケースを持ち帰ることができる商品配送サービスである。配送者によって輸送ケースが回収されることにより、配送容器は通函としての機能を有する。
【００１６】
【実施例】
以下に本発明の実施例を説明する。
【００１７】
【実施例１】
臨床検査用の精度管理用凍結液状血清を調製し、検査部門からの発注を想定して配送を行った。輸送ケースとして保温ジャーを用い内部に容器入り凍結血清を図１に示す温度インジケーター付で梱包・配送した。配達には、約２４時間を要したが配達員が検査部門担当者とともに梱包を開封し、温度インジケーターを確認したところ、−１８℃以上にはなった履歴は表示されておらず安全指標が提示されていたので、信頼性ある精度管理試薬として利用された。
【００１８】
【実施例２】
前記実施例と同様に配達を行ったが、配達途上で輸送ケースが一部破損した。
配達員が検査部門担当者とともに梱包を開封して図１に示す温度インジケーターを確認したところ、−１８℃以上に数時間曝されたことを表示するマーカーを認めた。配達員はその場で直ちに配送部門に連絡し、迅速な代替え製品の提供を可能とした。
【００１９】
【実施例３】
実施例１及び２において、保温ジャーは配達後回収され通函箱としての機能を発揮した。
【００２０】
【発明の効果】
この温度管理方法の特徴は、商品輸送ケース内の温度履歴を顧客が商品受領時に一目瞭然と認知可能とし、厳格な商品規格の維持が要求される商品の極めて顧客の立場にたった品質保証を可能とするものである。これにより、高度品質維持と高い顧客信頼を得ることが可能となる。
【図面の簡単な説明】
【図１】第１図は、温度インジケーターを示す。[0001]
BACKGROUND OF THE INVENTION
The present invention relates to a temperature management method for storing and delivering a frozen liquid sample obtained by freezing a liquid clinical test reagent or a liquid sample as a raw material thereof in a transport case .
[0002]
[Prior art]
In order to maintain the quality of a frozen liquid sample obtained by freezing a liquid clinical test reagent or a liquid sample used as a raw material thereof, it is prohibited to freeze the sample once thawed. For this reason, frozen liquid samples have been delivered in a small amount of foamed polystyrene packed in dry ice. However, the delivery usually takes one to several days, and if the delivery time is long, there is a problem that dry ice is consumed and the temperature control may not be sufficient especially in summer.
[0003]
Even if the frozen sample undergoes a temperature change for some reason during delivery, if the sample is delivered to the customer in a frozen state under the subsequent delivery conditions, the deterioration of the sample cannot be confirmed when the product is received was there. Furthermore, even if an abnormality occurs in the measured value using a frozen sample, it is possible to identify whether a temperature management problem has occurred for the reagent during delivery or due to a technical problem of the person who performed the measurement. It was difficult.
[0004]
Furthermore, when the product made of expanded polystyrene is used, a large amount of dry ice is required to maintain the temperature, and this is not economically and environmentally favorable.
[0005]
[Problems to be solved by the invention]
The object of the present invention is confirmed frozen liquid samples were frozen liquid sample comprising a liquid clinical examination reagents and their raw materials, whether or not exposed for a predetermined time or more in a temperature deviating from your stomach specified temperature distribution developing of its It is to provide a temperature control method for a possible frozen liquid sample.
[0006]
[Means for Solving the Problems]
The present invention
1. A temperature control method for freezing liquid sample stored in a transport case having a temperature retention function for the delivery, or freezing a liquid sample of the material intended freezing liquid sample was frozen reagent liquid clinical examination When the temperature inside the transport case rises above the specified temperature, the color changes in multiple stages depending on the duration, and the temperature changes during delivery can be managed. A method for temperature management of a frozen liquid sample, characterized in that it is possible to confirm whether or not the frozen liquid sample has been exposed to a temperature deviating from a specified temperature for a predetermined time using an indicator,
2. The temperature management method for a frozen liquid sample according to item 1 above, wherein the specified temperature is -18 ° C,
3. The temperature management method for a frozen liquid sample according to the preceding item 1 or 2, characterized in that it is possible to confirm with a temperature indicator that the frozen liquid sample is guaranteed at a specified temperature when the transport case is unpacked.
4). 4. The method for temperature control of a frozen liquid sample according to any one of items 1 to 3, wherein the transport case is reused.
5. The method for temperature control of a frozen liquid sample according to any one of the preceding items 1 to 4, wherein the transport case is a jar,
Consists of.
[0007]
DETAILED DESCRIPTION OF THE INVENTION
The product delivery service method of the boxing method is a so-called return box method, which stores the target product in the transport case when the customer requests the product delivery, delivers the product to the target customer, and after the delivery is completed A product delivery service method comprising collecting at least a transport case. Further, a cardboard case / or a polystyrene foam case used as an outer box may be collected depending on the purpose.
[0008]
As a preferred embodiment, the frozen liquid sample is packed in a transport case together with dry ice and a temperature indicator, and when heat retention is required, it can be delivered in, for example, polystyrene foam. By packing the temperature indicator together with the frozen liquid sample, it becomes an index indicating that the sample is not refrozen after thawing, and a highly reliable sample can be provided.
[0009]
In addition, when the distribution sender is delivering the goods to the customer, unpack delivery person and / or the customer is, by checking the temperature indicator on the spot, be sure that the sample is specified temperature guarantee I can .
[0010]
Products to be delivered in the present invention Ri samples der freezing liquid, include those that disable to refrozen that once thawed. Such freezing liquid sample, clinical test reagents, enzyme product, or the sample or the like as the raw materials thereof are exemplified. Et al is, these are illustrated test control sample and calibrators are specifically as substances contained in these enzymes (AST, ALT, LD-1 , CK, ALP, AMY, P-AMY, LAP, γ-GT, CHE, etc.), lipids (TG, T-CHO, F-CHO, PL, etc.), proteins (TP, ALB, CRP, etc.), non-protein nitrogen components (UN, CRE, UA, etc.), inorganic substances ( Preferred examples include Ca, Mg, IP, Fe, Na, K, Cl, etc.), carbohydrates (GLU, SA, etc.), and biological pigments (T-BIL, D-BIL, etc.).
[0011]
In the present invention, the sample / commodity is in a frozen state. The storage temperature can be maintained below zero degrees Celsius. A particularly preferable storage temperature is −18 ° C. or lower. Dry ice is preferably used to maintain the low temperature in the transport case.
In the present invention, the sample / commodity is stored in a transport case having a reusable temperature holding function. As such a transport case, for example, a styrene foam, a jar having a temperature holding function, a common name thermos, and the like are exemplified. Preferably, by using a jar having a temperature maintaining function, the amount of dry ice to be used can be reduced, which is economical.
[0013]
In the present invention, the sample / commodity can guarantee the specified temperature of the sample during the delivery of the frozen liquid sample. In other words, if the sample / commodity is exposed to a situation at or above the delivery specified temperature in the course of delivery due to a temperature rise, the customer can clearly determine the history at the time of receiving the sample / commodity. Furthermore, the present invention is a product for confirming that a sample is guaranteed at a specified temperature by unpacking the product in the presence of the customer and checking the temperature indicator on the spot when the deliverer delivers the product to the customer. By providing a delivery service, it is possible to eliminate the risk of a customer receiving a sample that is likely to be denatured or out of specification, for example.
[0014]
For this guarantee, the method of the present invention employs a temperature indicator that enables management of temperature changes during delivery. The temperature indicator can display a plurality of levels according to the degree of time elapsed when exposed to a temperature deviating from a specified temperature. For example, if it is exposed to −18 ° C. or more for about 3 hours, it is possible to discriminate such as a caution signal, and if it is higher, a danger signal.
[0015]
The present invention is a merchandise delivery service that allows a delivery person to take a transport case home after delivering the merchandise to a customer. By collecting the transport case by the delivery person, the delivery container has a function as a box.
[0016]
【Example】
Examples of the present invention will be described below.
[0017]
[Example 1]
Frozen liquid serum for quality control for clinical tests was prepared and delivered assuming an order from the testing department. Using a heat insulating jar as a transport case, the frozen serum contained in a container was packed and delivered with the temperature indicator shown in FIG. Delivery took about 24 hours, but the delivery person opened the package with the person in charge of the inspection department and checked the temperature indicator. It was used as a reliable quality control reagent.
[0018]
[Example 2]
Delivery was performed in the same manner as in the previous example, but the shipping case was partially damaged during delivery.
When the delivery person opened the package together with the person in charge of the inspection department and checked the temperature indicator shown in FIG. 1, a marker indicating that it was exposed to −18 ° C. or more for several hours was recognized. The delivery person immediately contacted the delivery department on the spot to provide a quick replacement product.
[0019]
[Example 3]
In Examples 1 and 2, the heat insulating jar was collected after delivery and exhibited a function as a box.
[0020]
【Effect of the invention】
The feature of this temperature management method is that customers can clearly recognize the temperature history in the product transport case when receiving the product, and it is possible to guarantee the quality of the product that requires the maintenance of strict product standards in the very customer's position. To do . As a result, high quality maintenance and high customer trust can be achieved.
[Brief description of the drawings]
FIG. 1 shows a temperature indicator.
Claims (5)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000286308A JP4879390B2 (en) | 2000-09-21 | 2000-09-21 | Temperature control method for frozen liquid samples |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000286308A JP4879390B2 (en) | 2000-09-21 | 2000-09-21 | Temperature control method for frozen liquid samples |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002096910A JP2002096910A (en) | 2002-04-02 |
| JP2002096910A5 JP2002096910A5 (en) | 2007-10-11 |
| JP4879390B2 true JP4879390B2 (en) | 2012-02-22 |
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| Application Number | Title | Priority Date | Filing Date |
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| JP2000286308A Expired - Lifetime JP4879390B2 (en) | 2000-09-21 | 2000-09-21 | Temperature control method for frozen liquid samples |
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Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3838368A1 (en) * | 1988-11-11 | 1990-05-17 | Holzer Walter | MELTING INDICATOR FOR MONITORING TEMPERATURE-SENSITIVE PRODUCTS |
| JPH0315378A (en) * | 1989-06-13 | 1991-01-23 | Katayama Susumu | Condensation of fermentated raw vinegar and equipment therefor |
| US5085802A (en) * | 1991-01-31 | 1992-02-04 | Oscar Mayer Foods Corporation | Time temperature indicator with distinct end point |
| JP2000043946A (en) * | 1998-08-03 | 2000-02-15 | Toru Sueyoshi | Container for cryogenic storage and transportation |
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2000
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