JP4920276B2 - Noble metal colloid-encapsulating lamella structure, dispersion thereof, cosmetic containing the same, and method for producing the dispersion - Google Patents

Description

  The present invention relates to a lamellar structure containing a precious metal colloid, a dispersion thereof, a cosmetic containing the same, and a method for producing the dispersion, and specifically, a fatty acid monoglyceride containing a precious metal colloid as a main constituent. The present invention relates to a lamellar structure, a dispersion thereof, a cosmetic containing the same, and a method for producing the dispersion. Furthermore, the present invention relates to a method for stabilizing a lamellar structure dispersion containing a fatty acid monoglyceride as a main constituent using a noble metal colloid.

Conventionally, in the cosmetic field, for the purpose of improving skin aging such as ultraviolet rays and wrinkles due to aging, substances having a moisturizing action, such as polyhydric alcohols, carbohydrates, organic acids, amino acids, polymers It is generally practiced to mix substances (see Non-Patent Document 1), but these existing substances that have a moisturizing effect cannot be obtained sufficiently, or if a certain amount or more is added Since it has been pointed out that the value may be impaired, a method using a corneocyte lipid or an analog thereof has been reported as an alternative (see, for example, Patent Document 1).
This interstitial lipid is considered to contribute to the barrier function by forming a lamellar structure in the living skin, and therefore it is artificially made of lamella structures (“liposomes”) using phospholipids and the like. Have also been proposed, and the present inventors have so far proposed excellent moisturizing properties for dispersions containing lamellar structures mainly composed of fatty acid monoglycerides. It has been found that it has an action, and a technique using this has been reported (Patent Document 2).

In addition, the present inventors have used a lamellar structure whose main component is a fatty acid monoglyceride that they have reported, and vitamin A, which has an excellent inhibitory effect on the formation of rough skin and wrinkles. It was reported that new functionality was added and it could be used for cosmetic development (Patent Document 3).
However, the lamellar structure comprising fatty acid monoglyceride as the main component has characteristics such as a very low quality and storage stability as a dispersion compared to a lamellar structure composed of general phospholipids. Therefore, there is a demand for a method for improving this, and the present inventors have also reported a technique related to this (Patent Document 4).

On the other hand, precious metal colloids can be used in various fields, and in particular, gold colloids have long been known to be specifically colored, such as reddish purple, depending on the size of the particles. It has been used for coloring. In addition, colloidal gold has been reported to be superior in safety and the like compared to pigments and the like generally used for coloring, and in the cosmetics field, the purpose is to improve the identification characteristics and preferences of products. Many techniques for coloring using this have been reported.
Examples of such techniques include cosmetics containing a purple pigment coated with gold on the carrier surface (Patent Document 5), cosmetics containing gold ultrafine particle fixed oxide (Patent Document 6), and surfactants. Or the cosmetics (patent document 7) etc. containing the gold colloid aqueous solution which made water-soluble polymer adsorb | suck can be mentioned.
Physiological research on precious metal colloids has also been promoted, and it has an action of eliminating active oxygen, which is considered to be closely related to diseases such as arteriosclerosis, inflammation, aging, and carcinogenesis (Patent Documents) 8) is reported, and it is expected to be used not only for coloring action but also for its functionality, and is expected to be used in the cosmetics field. Noble metal colloids are applied to lamellar structures containing phospholipids as the main constituent. A technique for inclusion is also reported (Non-Patent Document 2).
JP 63-192704 A Japanese Patent No. 2606761 Patent No. 3641152 JP-A-8-59449 JP-A-1-215865 Japanese Patent Laid-Open No. 2-104512 Japanese Patent No. 2758497 JP 2004-285166 A Sekine Shigeru, Cosmetics Handbook, Nippon Chemicals Co., Ltd., P445-448, 1996 Oren Regev, Renal Bakov, Chrystel Faure, Chem. Mater., 2004, 16, 5280-5285

However, since the lamella structure has greatly different properties and physical properties depending on the type of constituent components, it is not always easy to encapsulate the noble metal colloid, and in particular, the fatty acid monoglyceride having extremely low quality and storage stability as a dispersion. It is difficult to encapsulate noble metal colloids in a lamellar structure having a main component.
Accordingly, an object of the present invention is to encapsulate a noble metal colloid and be used in the cosmetics field. In addition to excellent moisturizing action, it has new functionality and is extremely high in quality and storage stability. An object of the present invention is to provide an industrially advantageous method for producing a lamellar structure dispersion containing an excellent fatty acid monoglyceride as a main constituent and a method for using the resulting lamellar structure dispersion in the cosmetic field.

  In view of such circumstances, the present inventor has conducted extensive research to solve the above problems, and as a result, added a noble metal salt aqueous solution and a reducing agent to a lamellar structure dispersion containing fatty acid monoglyceride as a main constituent, By stirring under heating, precious metal colloids can be encapsulated, and in addition to moisturizing action, this has new functionality, is preserved, and has very good quality stability. The present invention has been completed.

That is, the present invention
(A) preparing a lamellar structure dispersion containing fatty acid monoglyceride as a main constituent,
(B) adding a noble metal salt aqueous solution and a reducing agent to the dispersion;
(C) Next, the present invention provides a method for producing a noble metal colloid-encapsulated lamellar structure dispersion characterized by stirring at room temperature or under heating.

The present invention also provides a noble metal colloid-encapsulated lamellar structure in which a noble metal colloid is included in a lamellar structure containing a fatty acid monoglyceride as a main constituent, and a dispersion thereof.
Furthermore, this invention provides the cosmetics containing the noble metal colloid inclusion lamella structure in which the noble metal colloid is included in the lamella structure which has fatty acid monoglyceride as a main component.
Furthermore, the present invention provides a method for stabilizing a lamellar structure dispersion containing a fatty acid monoglyceride as a main constituent, which comprises blending a noble metal colloid with a lamellar structure dispersion containing a fatty acid monoglyceride as a main constituent. It is to provide.

  The noble metal colloid-encapsulated lamellar structure dispersion of the present invention refers to a liquid in which a lamellar structure in which the noble metal colloid is incorporated is dispersed in an aqueous solution. Here, the noble metal colloid is not particularly limited as long as it is taken into the lamellar structure.

  The noble metal colloid-encapsulating lamella structure of the present invention can be a new functional material having an excellent moisturizing action and added with the physiological action of the encapsulating noble metal colloid. In addition, this lamella structure dispersion is colored depending on the type of precious metal colloid to be encapsulated, etc., so that it can be used not only for the addition of functionality but also for the purpose of enhancing the identification characteristics and preferences of products as before. Is also possible. Furthermore, by including a noble metal colloid, a lamellar structure dispersion liquid containing fatty acid monoglyceride with improved quality and storage stability as a main constituent can be easily obtained, and its use is facilitated.

First, a method for producing a noble metal colloid-encapsulated lamella structure dispersion will be described.
In the method of the present invention, first, as step (A), a lamellar structure dispersion liquid containing fatty acid monoglyceride as a main constituent is prepared. Here, the main constituent component means that the fatty acid monoglyceride occupies 30% by weight or more of the constituent component excluding the aqueous phase component of the lamellar structure, and particularly preferably 50% by weight. Here, examples of the fatty acid monoglyceride that is a main component of the lamellar structure include monoglycerides of saturated or unsaturated fatty acids having 8 to 18 carbon atoms, such as caprylic acid monoglyceride, capric acid monoglyceride, lauric acid monoglyceride, Examples include myristic acid monoglyceride, palmitic acid monoglyceride, stearic acid monoglyceride, and oleic acid monoglyceride. These may be used alone or in combination of two or more. Among them, when palmitic acid monoglyceride and stearic acid monoglyceride are used as fatty acid monoglycerides in a ratio of 4: 6 to 2: 8, a lamellar structure is easily formed in an aqueous solution, and precious metal colloids tend to be included. ,preferable.

  In addition, as described above, the lamellar structure of the present invention contains fatty acid monoglyceride as a main constituent, but other components are mixed within a range that does not impair the stability of structure and quality (including functionality). It is also possible to use the obtained oil phase mixture as a constituent. Examples of such components include cholesterol, monostearyl glyceryl ether, diglycerin fatty acid ester, and the like. Among them, cholesterol has an action of structuring the stability of a lamellar structure, and is therefore blended in. It is preferable. The blending amount of these components may be set within a preferable range as appropriate, but is approximately 0.05 to 5 parts by weight, preferably 0.1 to 3 parts by weight with respect to 1 part by weight of the fatty acid monoglyceride as the main component. It is preferable to set it as the range.

Preparation of the lamella structure dispersion liquid used as the (A) process of the present invention can be performed by any one of the following two methods. Hereinafter, the preparation method will be exemplified.
First, as a first method, after heating and melt-mixing fatty acid monoglyceride or an oil phase mixture containing the same, an aqueous phase maintained at the same temperature is added, and the oil phase is physically stirred to The method of preparing by dispersing in an aqueous phase can be mentioned. Here, the heating temperature at the time of melt mixing and addition of the aqueous phase is preferably 45 ° C to 100 ° C, particularly preferably 45 ° C to 80 ° C, and further preferably 50 ° C to 80 ° C. In addition, existing equipment may be used for physical stirring, for example, an ultrasonic emulsifying device, a high-pressure uniform dispersion device, a nanomizer, a homomixer, a homogenizer, a colloid mill, a high-speed stirrer, or the like may be used. . The conditions for physical stirring and the like are not particularly limited, and may be performed according to a conventional method.

  In the second method, a fatty acid monoglyceride or an oil phase mixture containing the fatty acid monoglyceride is dissolved in an organic solvent, and then the solvent is distilled to deposit a lipid layer. The method of preparing by irradiating a sound wave can be mentioned. Examples of the organic solvent used here include dichloromethane, chloroform, acetone, methanol, and the like. Among them, acetone is preferably used in consideration of workability and safety.

Although it is possible to prepare a lamella structure dispersion liquid by any of the above methods, the means of the first method is preferable for efficient preparation on an industrial scale.
In addition, the lamellar structure dispersion of the present invention is in a closed state in which the lamellar phase composed of an oil phase and an aqueous phase is not plate-like, because of the characteristics of the fatty acid monoglyceride that is the main constituent, Specifically, a structure in which a multi-shaped circle or polygon formed of a plurality of oil phases and water phases is dispersed in an aqueous solution is present.

  Next, as the step (B), a noble metal salt aqueous solution and a reducing agent are blended into the lamellar structure dispersion containing the fatty acid monoglyceride obtained as described above as a main constituent. Examples of the noble metal salt aqueous solution to be blended here include salts of noble metals such as gold, platinum, palladium, etc., and one or more of these can be used in combination. Specific examples of these noble metal salts include tetrachlorogold (III) acid, tetrachlorogold (III) potassium, tetrachlorogold (III) sodium, tetrachlorogold (III) ammonium, and tetrachloroplatinum. (II) acid, potassium tetrachloroplatinum (II), sodium tetrachloroplatinum (II), ammonium tetrachloroplatinum (II), hexachloroplatinum (IV) acid, potassium hexachloroplatinum (IV), hexachloroplatinum ( IV) Sodium acid, ammonium hexachloroplatinum (IV), sodium palladium (II) chloride, potassium tetrachloropalladium (II), ammonium tetrachloropalladium (II) and the like. Among them, a salt made of gold or platinum, specifically, tetrachlorogold (III) acid or hexachloroplatinum (IV) acid is preferable. The amount of the noble metal salt aqueous solution is preferably such that the concentration of the noble metal salt in the finally obtained noble metal colloid-encapsulated lamellar structure dispersion is 0.01 mM to 0.7 mM, particularly 0.1 mM to 0.00. An amount of 6 mM is preferred.

  On the other hand, the reducing agent to be blended together with the noble metal salt aqueous solution can be used without particular limitation as long as it is an existing reducing agent that is generally used. For example, hydrazine, sodium borohydride, trisodium citrate, ascorbic acid and the like can be mentioned, and trisodium citrate is particularly preferable. In addition, although the compounding quantity of a reducing agent is not specifically limited, It is 2: 1 to 1:10 by the ratio (molar ratio, noble metal salt: reducing agent) of the noble metal salt aqueous solution to mix | blend, Preferably it is 1: 1. It is preferable to mix | blend so that it may become -1: 5. Further, the timing of addition of the reducing agent is not particularly limited, and may be after the noble metal salt aqueous solution is mixed with the lamellar structure dispersion containing the fatty acid monoglyceride as the main constituent simultaneously with the noble metal salt aqueous solution.

In the method of the present invention, it is preferable that a pH adjusting agent is blended simultaneously with a lamellar structure dispersion containing fatty acid monoglyceride as a main constituent when a noble metal salt aqueous solution and a reducing agent are blended. Examples of the pH adjusting agent that can be blended here include potassium carbonate (K ₂ CO ₃ ), sodium hydroxide (NaOH), potassium hydroxide (KOH), malic acid, citric acid, and various buffer solutions. The blending amount is preferably such that the liquid concentration after addition is 0.01 mM to 1.0 mM, and particularly preferably 0.05 mM to 0.5 mM.

  As described above, a precious metal colloid is prepared by mixing a lamellar structure dispersion containing a fatty acid monoglyceride as a main constituent with a noble metal salt aqueous solution and a reducing agent and then stirring at room temperature or under heating as step (C). An encapsulated lamellar structure dispersion can be prepared. The temperature condition is preferably 25 ° C. to 70 ° C., particularly preferably 25 ° C. to 60 ° C., from the viewpoint of efficiently encapsulating the noble metal colloid in the lamella structure. The stirring may be performed by an existing method and is not particularly limited.

  Furthermore, in the method of the present invention, it is preferable that a noble metal colloid is encapsulated in a lamellar structure containing a fatty acid monoglyceride as a main component, and then, as the step (D), a water-soluble polymer substance is blended and stirred. . As a result, the quality and storage stability of the precious metal colloid-encapsulated lamellar structure dispersion containing the fatty acid monoglyceride as a main constituent can be further improved. Examples of the water-soluble polymer substance used here include polyvinyl pyrrolidone, xanthan gum, hyaluronic acid and / or a salt thereof, carboxyvinyl polymer, hydroxyethyl cellulose, hydroxypropyl cellulose, guar gum, carrageenan and the like. However, you may use 2 or more types together. Further, the blending amount of these water-soluble polymer substances may be 0.01 wt% to 5 wt%, preferably 0.1 wt% to 3 wt% in the final lamellar structure dispersion. . In addition, stirring conditions etc. are not specifically limited.

  The noble metal colloid-encapsulated lamellar structure dispersion thus obtained is superior in quality and storage stability compared to a conventional lamellar structure dispersion containing a fatty acid monoglyceride as a main constituent, and in addition to excellent moisture retention, Since it has physiological activities such as antioxidant activity of noble metal colloids, it can be used for cosmetics and the like. In addition, the lamellar structure dispersion obtained by the method of the present invention may be a colored component exhibiting a purple color or the like due to the characteristics of the precious metal colloid to be blended, and enhances product identification characteristics and preferences in cosmetics. It can also be used for this purpose.

Cosmetics that can be blended with the precious metal colloid-encapsulated lamellar structure dispersion obtained by the method of the present invention include basic cosmetics such as lotions, emulsions, creams, packs, shampoos, rinses, treatments, hair Examples include hair products such as tonics, hair liquids, hair creams and hair milks, cosmetics for baths such as bathing agents and soaps, makeup cosmetics such as foundations, lipsticks, mascaras and eye shadows, and special cosmetics such as sunscreens.
These cosmetics can be blended with various auxiliary materials that are generally blended into cosmetics. Such secondary materials include surfactants, oils, alcohols, humectants, thickeners, preservatives, antioxidants, chelating agents, pH adjusters, fragrances, dyes, UV absorbers / scatterers, powders Vitamins, amino acids, water-soluble polymers, foaming agents, pigments, plant extracts, animal-derived components, seaweed extracts, various drugs, additives, water, and the like.

  In addition, if the noble metal colloid is added to the lamellar structure dispersion containing fatty acid monoglyceride as the main constituent, the dispersion can be stabilized. Therefore, the method of the present invention is used as a method for stabilizing the dispersion. Is also useful.

  EXAMPLES Hereinafter, although an Example is given and this invention is demonstrated further in detail, this invention is not restrict | limited at all to these.

Example 1
<Preparation of precious metal colloid-encapsulated lamellar structure dispersion 1-Confirmation of formation of lamellar structure->
Fatty acid monoglyceride (Poem S-100; manufactured by Riken Vitamin Co., Ltd.) 200 mg, batyl alcohol 60 mg, and cholesterol 84 mg were dissolved in 20 ml of acetone, 10 ml of the resulting solution was added to a container, and acetone was distilled to deposit lipids. . 9.37 ml of purified water was added to the container in which the lipid was deposited, and after heating to 80 ° C., irradiation with ultrasonic waves (SONIFIER made by Branson) was applied to prepare a lamellar structure dispersion. To this dispersion, 0.63 ml of an aqueous solution of 0.64 mM trisodium citrate dihydrate, 0.16 mM calcium carbonate and 0.2 mM tetrachloroauric (III) acid tetrahydrate was added at a final concentration. The mixture was stirred while heating at 60 ° C. for 4 hours to obtain a purple dispersion.
In order to confirm whether or not a lamella structure was formed in the obtained dispersion liquid, the presence or absence of a dark cross was used as an index to observe with a polarizing microscope. The result is shown in FIG.

From FIG. 1, it was confirmed that a lamellar structure containing fatty acid monoglyceride as a main constituent is present in the obtained purple dispersion.
Test example 1
<Preparation of precious metal colloid-encapsulated lamella structure dispersion 2-Presence / absence of precious metal colloid inclusion->
Next, it was confirmed by the following method whether the noble metal colloid was included in the inside of the lamellar structure which has the fatty-acid monoglyceride which exists in the purple dispersion liquid prepared in the said Example 1 as a main component.
The purple dispersion prepared in Example 1 was observed with a transmission electron microscope (H-7650, manufactured by Hitachi High-Technology, Inc.) under the conditions of an acceleration voltage of 120 kV, an emission current of 3.0 μA, and a low dose condition mode of −173 ° C. Went. The result is shown in FIG.

  From FIG. 2, it was confirmed that the purple dispersion prepared in Example 1 had a lamellar structure containing a fatty acid monoglyceride encapsulating a noble metal colloid as a main component.

Example 2
<Verification of added amount of noble metal salt aqueous solution>
A noble metal colloid-encapsulated lamellar structure dispersion was prepared in the same manner as in Example 1 except that the compounding concentration of tetrachloroauric (III) acid tetrahydrate was 0.1 to 0.8 mM. The obtained dispersion liquid was visually confirmed and evaluated as follows. The results are shown in Table 1.

The visual evaluation criteria in the following table are as follows.
○: Precious metal colloid-encapsulated lamella structure is well dispersed ×: Precious metal colloid-encapsulated lamella structure is precipitated and / or aggregated

  From the results of Table 1, it was revealed that when the amount of the noble metal salt aqueous solution added exceeds 0.8 mM with respect to the total amount of the dispersion, the noble metal colloid-encapsulated lamella structure dispersion is not maintained in a good state.

Example 3
<Conditions for precious metal colloid inclusion>
After adding an aqueous solution containing trisodium citrate dihydrate, calcium carbonate, and tetrachloroauric (III) acid tetrahydrate to a lamellar structure dispersion containing fatty acid monoglyceride as a main constituent, the temperature of the solution is adjusted. A noble metal colloid-encapsulated lamellar structure dispersion was obtained in the same manner as in the production method of Example 1 except that the temperature was adjusted to 25 ° C. to 80 ° C. and stirring was performed. The obtained dispersion was visually confirmed with the same index as in Example 2. The results are shown in Table 2.

  From the results of Table 2, when the noble metal colloid is encapsulated in the lamellar structure dispersion containing fatty acid monoglyceride as the main constituent, the mixing conditions of the lamellar structure dispersion and the noble metal salt aqueous solution are set at room temperature or under heating. However, it was confirmed that the precious metal colloid-encapsulated lamellar structure dispersion liquid deteriorated when the heating temperature reached 80 ° C.

Example 4
<Stability evaluation of lamella structure dispersion containing precious metal colloid>
Fatty acid monoglyceride (Poem S-100; manufactured by Riken Vitamin Co., Ltd.) 200 mg, batyl alcohol 60 mg, and cholesterol 84 mg were dissolved in 20 ml of acetone, 10 ml of the resulting solution was added to a container, and acetone was distilled to deposit lipids. . 10.00 ml of purified water is added to the container in which this lipid is deposited, heated to 80 ° C., irradiated with ultrasonic waves (SONIFIER made by Branson), and further added with 1 g of polyvinylpyrrolidone (10% aqueous solution) to give a lamellar structure A body dispersion was prepared (Comparative product 1). In addition, a dispersion prepared with 9.36 ml of purified water by the above production method was added to a final concentration of 0.64 mM trisodium citrate dihydrate, 0.16 mM calcium carbonate and 0.2 mM tetrachlorogold (III). 0.63 ml of an aqueous solution to be acid tetrahydrate was added and stirred while heating at 60 ° C. for 4 hours, and 1 g of polyvinylpyrrolidone (10% aqueous solution) was further added to obtain a purple lamellar structure dispersion (this product) Invention 1).
In order to confirm whether or not the lamella structure was formed in the obtained lamella structure dispersion liquid (Comparative product 1 and Product 1 of the present invention), it was observed with a polarizing microscope using the presence or absence of a dark cross as an index. Further, this dispersion was stored at room temperature for 14 days, and the state of the dispersion after storage was confirmed with a polarizing microscope. The results are shown in FIGS.

  From the results of FIGS. 3 to 6, the lamellar structure (FIG. 5) containing fatty acid monoglyceride encapsulating the noble metal colloid as the main component does not contain the noble metal colloid even when stored (FIG. 6). It was confirmed that the lamella structure (FIGS. 3 and 4) having fatty acid monoglyceride as a main component is superior in stability.

Example 5
<Preparation of precious metal colloid-encapsulated lamella structure dispersion 3>
Fatty acid monoglyceride (Poem S-100; manufactured by Riken Vitamin Co., Ltd.) 200 mg, batyl alcohol 60 mg, and cholesterol 84 mg were dissolved in 20 ml of acetone, 10 ml of the resulting solution was added to a container, and acetone was distilled to deposit lipids. . 9.37 ml of purified water was added to the container in which the lipid was deposited, and after heating to 80 ° C., irradiation with ultrasonic waves (SONIFIER made by Branson) was applied to prepare a lamellar structure dispersion. To this dispersion, 0.63 ml of an aqueous solution of 0.64 mM trisodium citrate dihydrate, 0.16 mM calcium carbonate and 0.2 mM tetrachloroauric (III) acid tetrahydrate was added at a final concentration. And stirring at 60 ° C. for 4 hours. Further, 1 g of polyvinyl pyrrolidone (10% aqueous solution) was added to this dispersion and further stirred to obtain a purple lamellar structure dispersion.

Example 6
<Manufacture of lotion>
Using the lamellar structure dispersion liquid prepared in Example 5, a lotion was produced as shown below according to the formulation shown in Table 3 below. First, component 1 in the table is dissolved by heating, and this is mixed with components 2, 3 and 4 and added to component 5. Components 6 to 16 were sequentially added to the resulting composition, mixed and dissolved, and then component 17 was added to obtain a lotion having a pH of 6.0.

Example 7
<Manufacture of milky lotion>
Using the lamella structure dispersion prepared in Example 5, an emulsion was produced as shown below according to the formulation shown in Table 4 below. First, the oil phase components 1 to 8 in the table are dissolved by heating. Similarly, the aqueous phase components 9 to 17 in the table were dissolved by heating, and the obtained oil phase component and aqueous phase component were combined and stirred with a homogenizer, then added component 18 and cooled, and further during the cooling Ingredients 19 and 20 were added and mixed to obtain an emulsion.

Example 8
<Manufacture of cream>
Using the lamella structure dispersion prepared in Example 5, a cream was produced as shown below according to the formulation shown in Table 5 below. First, the oil phase components 1 to 9 in the table are heated and dissolved. Similarly, 10-18, which are water phase components in the table, are dissolved by heating, and the obtained oil phase component and water phase component are combined and stirred with a homogenizer, then component 19 is added and cooled. Ingredients 20-22 were added and mixed to obtain a cream.

  The lamellar structure dispersion liquid containing fatty acid monoglyceride obtained by the present invention as a main constituent is a new functional material to which the physiological action of the precious metal colloid to be included is added in addition to the excellent moisturizing action of itself. It can be used for the development of cosmetics. In addition, this lamella structure dispersion is colored depending on the type of precious metal colloid to be encapsulated, etc., so that it can be used not only for the addition of functionality but also for the purpose of enhancing the identification characteristics and preferences of products as before. Is also possible. Furthermore, by including a noble metal colloid, a lamellar structure dispersion liquid containing fatty acid monoglyceride with improved quality and storage stability as a main constituent can be easily obtained, and its use is facilitated.

It is a polarizing microscope photograph of a lamella structure dispersion liquid. It is a transmission electron micrograph of a lamella structure. It is a polarizing microscope photograph of the comparative product 1 immediately after manufacture. It is a polarization microscope photograph of comparative product 1 after storage. It is a polarizing microscope photograph of this invention product 1 immediately after manufacture. It is a polarizing microscope photograph of this invention product 1 after a preservation | save.

Claims (7)

(A) preparing a lamellar structure dispersion containing fatty acid monoglyceride as a main constituent,
(B) A noble metal salt aqueous solution in an amount such that the noble metal salt concentration in the finally obtained noble metal colloid-encapsulated lamellar structure dispersion is 0.1 mM to 0.6 mM , and a reducing agent are added to the dispersion,
(C) Next, a method for producing a noble metal colloid-encapsulated lamellar structure dispersion, which is stirred in the range of 25 ° C to 70 ° C. The method for producing a noble metal colloid-encapsulated lamellar structure dispersion according to claim 1, wherein the fatty acid monoglyceride accounts for 30% by mass or more of the constituent components excluding the aqueous phase component of the lamellar structure. The method for producing a noble metal colloid-encapsulated lamella structure dispersion according to claim 1 or 2 , wherein the fatty acid monoglyceride is composed of a saturated or unsaturated fatty acid having 8 to 18 carbon atoms. The method for producing a noble metal colloid-encapsulated lamella structure dispersion according to any one of claims 1 to 3, further comprising (D) a step of adding a water-soluble polymer and stirring. A noble metal colloid-encapsulated lamellar structure dispersion obtained by the method according to any one of claims 1 to 4 . Cosmetics containing the noble metal colloid-encapsulating lamellar structure dispersion according to claim 5 . In the lamellar structure dispersion containing fatty acid monoglyceride as the main component, the precious metal colloid is blended in such an amount that the noble metal salt concentration in the finally obtained noble metal colloid-containing lamellar structure dispersion is 0.1 mM to 0.6 mM. A method for stabilizing a dispersion of a noble metal colloid-encapsulated lamellar structure containing a fatty acid monoglyceride as a main constituent, which is stirred in the range of 25 ° C to 70 ° C.