JP4989938B2 - Skin patch and skin patch sheet - Google Patents
Skin patch and skin patch sheet Download PDFInfo
- Publication number
- JP4989938B2 JP4989938B2 JP2006209987A JP2006209987A JP4989938B2 JP 4989938 B2 JP4989938 B2 JP 4989938B2 JP 2006209987 A JP2006209987 A JP 2006209987A JP 2006209987 A JP2006209987 A JP 2006209987A JP 4989938 B2 JP4989938 B2 JP 4989938B2
- Authority
- JP
- Japan
- Prior art keywords
- skin patch
- inulin
- water
- sheet
- patch
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000007933 dermal patch Substances 0.000 title claims description 25
- 229920001202 Inulin Polymers 0.000 claims description 30
- 229940029339 inulin Drugs 0.000 claims description 30
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 21
- 239000003995 emulsifying agent Substances 0.000 claims description 18
- 229920000642 polymer Polymers 0.000 claims description 16
- -1 inulin fatty acid ester Chemical class 0.000 claims description 15
- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical group O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 claims description 13
- 239000000017 hydrogel Substances 0.000 claims description 11
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 10
- 229930195729 fatty acid Natural products 0.000 claims description 10
- 239000000194 fatty acid Substances 0.000 claims description 10
- 239000000463 material Substances 0.000 claims description 6
- KYXMJYWUKCNPSD-UHFFFAOYSA-N dodecylcarbamic acid Chemical compound CCCCCCCCCCCCNC(O)=O KYXMJYWUKCNPSD-UHFFFAOYSA-N 0.000 claims description 5
- 239000000499 gel Substances 0.000 description 26
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 10
- 239000004480 active ingredient Substances 0.000 description 9
- 239000002537 cosmetic Substances 0.000 description 6
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 5
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 5
- 239000000853 adhesive Substances 0.000 description 5
- 230000001070 adhesive effect Effects 0.000 description 5
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 5
- 229940032094 squalane Drugs 0.000 description 5
- 229920003169 water-soluble polymer Polymers 0.000 description 5
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 4
- 238000004132 cross linking Methods 0.000 description 4
- 239000003431 cross linking reagent Substances 0.000 description 4
- CNRDTAOOANTPCG-UHFFFAOYSA-N dodecyl carbamate Chemical compound CCCCCCCCCCCCOC(N)=O CNRDTAOOANTPCG-UHFFFAOYSA-N 0.000 description 4
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 4
- 239000004745 nonwoven fabric Substances 0.000 description 4
- 239000003002 pH adjusting agent Substances 0.000 description 4
- 239000003755 preservative agent Substances 0.000 description 4
- 230000002335 preservative effect Effects 0.000 description 4
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- 235000011187 glycerol Nutrition 0.000 description 3
- 239000000758 substrate Substances 0.000 description 3
- 150000005846 sugar alcohols Polymers 0.000 description 3
- 239000004094 surface-active agent Substances 0.000 description 3
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- 229920002125 Sokalan® Polymers 0.000 description 2
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 2
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 2
- 229930003427 Vitamin E Natural products 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 238000013329 compounding Methods 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 2
- 229940119170 jojoba wax Drugs 0.000 description 2
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 2
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 2
- 229960002216 methylparaben Drugs 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 239000012071 phase Substances 0.000 description 2
- 239000004584 polyacrylic acid Substances 0.000 description 2
- 239000008213 purified water Substances 0.000 description 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 2
- 239000011975 tartaric acid Substances 0.000 description 2
- 235000002906 tartaric acid Nutrition 0.000 description 2
- 235000019155 vitamin A Nutrition 0.000 description 2
- 239000011719 vitamin A Substances 0.000 description 2
- 235000019165 vitamin E Nutrition 0.000 description 2
- 239000011709 vitamin E Substances 0.000 description 2
- 229940046009 vitamin E Drugs 0.000 description 2
- 229940045997 vitamin a Drugs 0.000 description 2
- 241000208838 Asteraceae Species 0.000 description 1
- 244000298479 Cichorium intybus Species 0.000 description 1
- 235000007542 Cichorium intybus Nutrition 0.000 description 1
- 244000115658 Dahlia pinnata Species 0.000 description 1
- 235000012040 Dahlia pinnata Nutrition 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- WQZGKKKJIJFFOK-DVKNGEFBSA-N alpha-D-glucose Chemical group OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-DVKNGEFBSA-N 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- WMGSQTMJHBYJMQ-UHFFFAOYSA-N aluminum;magnesium;silicate Chemical compound [Mg+2].[Al+3].[O-][Si]([O-])([O-])[O-] WMGSQTMJHBYJMQ-UHFFFAOYSA-N 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 229930014097 furanoid Natural products 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000003607 modifier Substances 0.000 description 1
- 239000007764 o/w emulsion Substances 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 229940060184 oil ingredients Drugs 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229960003471 retinol Drugs 0.000 description 1
- 235000020944 retinol Nutrition 0.000 description 1
- 239000011607 retinol Substances 0.000 description 1
- 229920002050 silicone resin Polymers 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 125000000185 sucrose group Chemical group 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Images
Landscapes
- Medicinal Preparation (AREA)
Description
本発明は、皮膚用貼付剤及び皮膚用貼付剤シート、さらに詳しくは、各種の有効成分をハイドロゲル粘着基剤とともに含有させた皮膚貼着用貼付剤と、そのような皮膚貼着用貼付剤を、不織布等の基材シートに具備させた貼付剤シートに関する。 The present invention relates to a skin patch and a skin patch sheet, more specifically, a skin adhesive patch containing various active ingredients together with a hydrogel adhesive base, and such a skin adhesive patch, The present invention relates to a patch sheet provided on a base material sheet such as a nonwoven fabric.
従来より、各種の有効成分をハイドロゲル粘着基剤とともに含有させた皮膚用貼付剤や、そのような貼付剤を不織布等の基材シートに具備させた貼付剤シートは、化粧料や医薬品等の分野において広く用いられている。 Conventionally, a skin patch containing various active ingredients together with a hydrogel adhesive base, and a patch sheet provided with such a patch on a base sheet such as a non-woven fabric are used for cosmetics, pharmaceuticals, etc. Widely used in the field.
たとえば化粧料用としては顔に貼付する顔パックシートと称されるようなものがあるが、このような化粧料用等の従来の貼付剤や貼付剤シートは、たとえば下記特許文献１や特許文献２等のように水性のゲルを具備させたものが多く、このような水性のゲルは水溶性の有効成分は好適に含有させることができるが、油性の有効成分は安定した状態で分散させることができず、結果的には、油性の有効成分を好適に含有させることができない。 For example, for cosmetics, there is a so-called face pack sheet that is applied to the face. Conventional patches and patch sheets for cosmetics and the like are, for example, the following Patent Document 1 and Patent Document In many cases, aqueous gels such as 2 are provided, and such water-based gels can preferably contain water-soluble active ingredients, but oily active ingredients should be dispersed in a stable state. As a result, the oily active ingredient cannot be suitably contained.
しかし、化粧料に用いられる油性成分としては、たとえばスクワラン油やホホバ油等の一般的な油性成分の他、ビタミンＡやビタミンＥ等のビタミン類にも油性のものがあり、このような油性成分を具備させることが制限されるのは、化粧料用パックシートの市場性や商品価値等の向上を妨げることにもなり、本来は好ましくない。また、皮膚は本来油に対する親和性は良好であるが、水に対する親和性はさほど良好ではない。従って上記のようなパックシートには、本来は、水性ゲルではなく、油性のゲルを具備させることが望ましい。 However, as the oily component used in cosmetics, for example, other common oil components such as squalane oil or jojoba oil, also vitamins such as vitamin A and vitamin E are as oily, such oil components However, it is difficult to improve the marketability and commercial value of the pack sheet for cosmetics. In addition, the skin has a good affinity for oil, but the affinity for water is not so good. Therefore, it is desirable that the pack sheet as described above should be provided with an oily gel instead of an aqueous gel.
このような観点から、油性のゲルを具備させたパックシートも一部に開発することが試みられたが、このようなゲルは１２０〜１５０度という非常に高い温度で生成するので、有効成分が分解されるおそれがあるという問題があった。 From this point of view, it was attempted to develop a part of a pack sheet provided with an oily gel. However, since such a gel is generated at a very high temperature of 120 to 150 ° C., the active ingredient is There was a problem that it might be decomposed.
従って、油性のゲルを具備させたパックシートを開発することは現実的ではなく、水性のゲル基剤にいかにして油性成分を含有させるかが重要となる。このようにすることで、水の貼付剤としての利点と、油性成分の貼付剤としての利点との双方を具備させることができる。しかし、このような水と油性成分との双方を具備させるには、界面活性剤や乳化剤等を配合することも必要となり、好適にゲルを形成するように、水、油性成分、乳化剤等を調合するのは実際には容易ではない。 Therefore, it is not practical to develop a pack sheet provided with an oily gel, and it is important how the oily component is contained in the aqueous gel base. By doing in this way, both the advantage as a patch of water and the advantage as a patch of an oil-based component can be provided. However, in order to provide both such water and oily components, it is also necessary to add a surfactant, an emulsifier, etc., so that water, an oily component, an emulsifier, etc. are prepared so as to form a gel suitably. It's actually not easy to do.
本発明は、このような点に鑑みてなされたもので、水性ゲルの利点を維持しつつ、油性ゲルの特徴も具備させて有効成分が油性成分であっても安定した状態で分散させることができ、しかも水と油性成分との双方をゲルに具備させたものでありながら、好適にゲルを形成させることのできる皮膚用貼付剤と皮膚用貼付剤シートを提供することを課題とする。 The present invention has been made in view of such points, and while maintaining the advantages of an aqueous gel, it can also be dispersed in a stable state even if the active ingredient is an oily component by providing the characteristics of an oily gel. It is another object of the present invention to provide a skin patch and a skin patch sheet that can form a gel suitably while being able to provide both water and an oil component in the gel.
本発明は、上記課題を解決するためになされたもので、ハイドロゲル基剤と、油性成分と、水と、イヌリンカルバミン酸エステル又はイヌリン脂肪酸エステルからなる高分子乳化剤とを含有することを特徴とする皮膚用貼付剤を提供する。 The present invention has been made to solve the above-described problems, and includes a hydrogel base, an oil component, water, and a polymer emulsifier composed of inulin carbamic acid ester or inulin fatty acid ester. A skin patch is provided.
また本発明は、ハイドロゲル基剤と、油性成分と、水と、イヌリンカルバミン酸エステル又はイヌリン脂肪酸エステルからなる高分子乳化剤とを含有する皮膚用貼付剤を、シート基材の表面に設けた皮膚用貼付剤シートを提供する。 The present invention also provides a skin provided with a skin patch comprising a hydrogel base, an oily component, water, and a polymer emulsifier composed of inulin carbamic acid ester or inulin fatty acid ester on the surface of a sheet base material. An adhesive patch sheet is provided.
高分子乳化剤としては、上記イヌリンカルバミン酸エステル又はイヌリン脂肪酸エステルのうちでも、イヌリンカルバミン酸エステルを用いるのが好ましく、とりわけラウリルカルバミン酸イヌリンが好適に用いられる。 As the polymer emulsifier, inulin carbamic acid ester is preferably used among the inulin carbamic acid ester or inulin fatty acid ester, and inulin lauryl carbamate is particularly preferably used.
また、油性成分の含有量は１〜５０重量％であることが好ましく、水の含有量は２０〜６０重量％であることが好ましい。さらに高分子乳化剤の含有量は０．０１〜３重量％であることが好ましい。 Moreover, it is preferable that content of an oil-based component is 1 to 50 weight%, and it is preferable that content of water is 20 to 60 weight%. Furthermore, the content of the polymer emulsifier is preferably 0.01 to 3% by weight.
本発明の皮膚用貼付剤は、上述のように、ハイドロゲル基剤と、油性成分と、水の他に、イヌリンカルバミン酸エステル又はイヌリン脂肪酸エステルからなる高分子乳化剤を含有させたものであるため、水の量に匹敵するほどの多量の油性成分を含有させても、水と油性成分との乳化機能を好適に生じさせることができ、しかもゲル形成能を好適に生じさせることができるという効果がある。 As described above, the skin patch of the present invention contains a polymer emulsifier composed of inulin carbamic acid ester or inulin fatty acid ester in addition to the hydrogel base, the oil component, and water. The effect that the emulsifying function of water and the oily component can be suitably produced even when a large amount of the oily component comparable to the amount of water is contained, and the gel forming ability can be suitably produced. There is.
また、多量の油性成分を含有させることができるので、油性の有効成分を安定した状態で分散させることができ、たとえば化粧料等用として使用される油性成分の配合が制限を受けることがないという効果がある。 In addition, since a large amount of oily components can be contained, oily active ingredients can be stably dispersed, and for example, the blending of oily components used for cosmetics and the like is not restricted. effective.
また、油性成分とともに、水も含有するものであるため、使用感、保湿性、皮膚の保護作用等、ハイドロゲルが本来有する利点を損なうこともない。 Moreover, since it contains water together with the oil component, the advantages inherent to the hydrogel, such as a feeling of use, moisture retention, and skin protection, are not impaired.
本発明の皮膚用貼付剤は、上述のようにハイドロゲル基剤と、油性成分と、水の他に、イヌリンカルバミン酸エステル又はイヌリン脂肪酸エステルからなる高分子乳化剤を含有させたものである。 The skin patch of the present invention contains a polymer emulsifier composed of inulin carbamic acid ester or inulin fatty acid ester in addition to the hydrogel base, the oily component, and water as described above.
ハイドロゲル基剤としては、たとえば水溶性高分子のようなものが用いられる。水溶性高分子の種類は特に限定されないが、たとえばポリアクリル酸、ポリビニルアルコール、ポリビニルピロリドン、ゼラチン、ペクチン等を使用することができる。水溶性高分子の含有量は特に限定されないが、３〜２０重量％であることが好ましい。 As the hydrogel base, for example, a water-soluble polymer is used. Although the kind of water-soluble polymer is not particularly limited, for example, polyacrylic acid, polyvinyl alcohol, polyvinyl pyrrolidone, gelatin, pectin and the like can be used. The content of the water-soluble polymer is not particularly limited, but is preferably 3 to 20% by weight.
また、油性成分としては、スクワラン油、ホホバ油、レチノール（ビタミンＡ）、トコフェロール（ビタミンＥ）等を使用することができる。油性成分の含有量は１〜５０重量％であることが好ましい。かかる範囲の含有量とすることで、油性の有効成分を安定した状態で分散させることができるとともに、ハイドロゲルの形成に支障をきたすこともない。 As the oil component, squalane oil, jojoba oil, retinol (vitamin A), tocopherol (vitamin E) and the like can be used. The oil component content is preferably 1 to 50% by weight. By setting the content in such a range, the oily active ingredient can be dispersed in a stable state, and the formation of the hydrogel is not hindered.
さらに、水の含有量は、２０〜６０重量％であることが好ましい。かかる範囲の含有量とすることで、油性成分を含有させることに支障を生じることがなく、またハイドロゲルの形成に支障をきたすこともなく、使用感、保湿性等、水性ゲルが本来有する機能を喪失させるおそれもないのである。 Furthermore, the water content is preferably 20 to 60% by weight. By setting the content in such a range, there is no hindrance to the inclusion of the oil component, and there is no hindrance to the formation of the hydrogel. There is no risk of losing it.
さらに、本発明は、イヌリンカルバミン酸エステル又はイヌリン脂肪酸エステルからなる高分子乳化剤を含有させる点に特徴がある。イヌリンは、たとえばチコリ、ダリヤ等のキク科植物から得られるもので、β−１，２結合したフラノイドフルクトース単位の鎖からなり、還元末端においてショ糖結合したα−Ｄ−グルコースを有する構造のものである。 Furthermore, the present invention is characterized in that a polymer emulsifier composed of inulin carbamic acid ester or inulin fatty acid ester is contained. Inulin is obtained, for example, from asteraceae plants such as chicory and dahlia, and is composed of a chain of β-1,2-linked furanoid fructose units, and has a structure having α-D-glucose bonded to sucrose at the reducing end. Is.
本発明では、このイヌリンのカルバミン酸エステル又は脂肪酸エステルが、高分子乳化剤として用いられる。イヌリンカルバミン酸エステルとしては、ラウリルカルバミン酸イヌリンを好適に使用することができる。またイヌリン脂肪酸エステルとしては、イヌリンステアリン酸エステル、イヌリンパルミチン酸エステル等を好適に使用することができる。
これらの中でも、特にラウリルカルバミン酸イヌリンを使用するのが好ましい。
In the present invention, this inulin carbamic acid ester or fatty acid ester is used as a polymer emulsifier. As the inulin carbamic acid ester, inulin lauryl carbamate can be preferably used. Inulin fatty acid esters such as inulin stearic acid ester and inulin lymphamic acid ester can be preferably used.
Of these, inulin laurylcarbamate is particularly preferably used.
ラウリルカルバミン酸イヌリンは、ＨＬＢ値が約８で、油性成分に対する溶解性は低いが、分散性は良好で、水に対する溶解性も低く、水相中で凝集する。そして水中油型乳濁液中では、イヌリン骨格が水和化されることによって、ラウリルカルバミン酸イヌリンが油滴粒子の表面に位置して立体的バリアーを形成し、その立体的バリアーによって、水相中で油滴粒子を包囲したような乳化構造を形成する。 Inulin laurylcarbamate has an HLB value of about 8 and low solubility in oily components, but has good dispersibility, low solubility in water, and aggregates in the aqueous phase. In the oil-in-water emulsion, the inulin skeleton is hydrated, so that the inulin laurylcarbamate is located on the surface of the oil droplet particles to form a three-dimensional barrier. An emulsified structure is formed in which oil droplet particles are surrounded.
このように、水相と油相の界面で特殊な乳化構造を形成するので、ラウリルカルバミン酸イヌリンの濃度が低くても、安定した分散状態を形成させることができる。高分子乳化剤の配合量は特に限定されないが、上記のようにイヌリン骨格が水和化されることによって、特殊な乳化構造を形成するので、０．０１〜３重量％程度の量で安定した分散状態が形成されることとなる。 Thus, since a special emulsification structure is formed at the interface between the water phase and the oil phase, a stable dispersion state can be formed even if the concentration of inulin laurylcarbamate is low. The blending amount of the polymer emulsifier is not particularly limited, but as the inulin skeleton is hydrated as described above to form a special emulsified structure, stable dispersion in an amount of about 0.01 to 3% by weight A state will be formed.
さらに本発明の皮膚用貼付剤には、ゲル架橋剤を含有させることができる。ゲル架橋剤としては、たとえばメタケイ酸アルミン酸マグネシウム、水酸化アルミニウム等が用いられる。 Further, the skin patch of the present invention may contain a gel crosslinking agent. As the gel crosslinking agent, for example, magnesium aluminate metasilicate, aluminum hydroxide or the like is used.
さらに本発明の皮膚用貼付剤には、ゲル架橋速度調整剤を含有させることができる。ゲル架橋速度調整剤としては、たとえばＥＤＴＡ−２Ｎａのようなものが用いられる。 Further, the skin patch of the present invention may contain a gel crosslinking rate adjusting agent. As the gel crosslinking rate adjusting agent, for example, EDTA-2Na is used.
さらに本発明の皮膚用貼付剤には、ｐＨ調整剤を含有させることができる。ｐＨ調整剤としては、たとえば酒石酸やコハク酸のようなものが用いられる。 Further, the skin patch of the present invention may contain a pH adjuster. As a pH adjuster, things like tartaric acid and succinic acid are used, for example.
さらに本発明の皮膚用貼付剤には、防腐剤を含有させることができる。防腐剤としては、たとえばメチルパラベンのようなものを使用することができる。 Furthermore, the skin patch of the present invention may contain a preservative. As the preservative, for example, methyl paraben can be used.
さらに本発明の皮膚用貼付剤には、グリセリン、グリコール、ポリエチレングリコール、ポリプロピレングリコール等の多価アルコールを含有させることができる。 Furthermore, the skin patch of the present invention may contain a polyhydric alcohol such as glycerin, glycol, polyethylene glycol, or polypropylene glycol .
本発明の皮膚用貼付剤シートは、図１に示すように、シート基材１の表面に貼付剤２が設けられ、さらにその貼付剤２の表面に剥離フィルム３が設けられた構成からなるものである。シート基材１は、たとえば不織布によって構成されている。また貼付剤２は上記のような構成からなるものである。さらに、剥離フィルム３は、たとえばポリエチレン、ポリプロピレン、ポリエステル等によって構成されている。尚、剥離フィルム３の貼付剤２と対面する側の面には、シリコン樹脂を塗布すること、或いはエンボス加工を施すことが可能である。
As shown in FIG. 1, the skin patch sheet of the present invention has a configuration in which a
一実施例の皮膚用貼付剤の組成は、次のとおりである。 The composition of the skin patch of one example is as follows.
配合成分 配合量（重量％）
ゲル架橋速度調整剤 ０．０８％
ｐＨ調整剤 ０．２０％
防腐剤 ０．１２％
ゲル架橋剤 ０．１２％
水溶性高分子 １０．６０％
スクワラン油 ２０．０％
高分子乳化剤 ０．５０％
多価アルコール ２４．００％
精製水 ４４．３８％
Compounding ingredients Compounding amount (wt%)
Gel crosslinking rate modifier 0.08%
pH adjuster 0.20%
Preservative 0.12%
Gel crosslinking agent 0.12%
Water-soluble polymer 10.60%
Squalane oil 20.0%
Polymer emulsifier 0.50%
Polyhydric alcohol 24.00%
Purified water 44.38%
高分子乳化剤としては、ラウリルカルバミン酸イヌリンを用いた。そして、このラウリルカルバミン酸イヌリンとしては、Ｏｒａｆｔｉ社製のＩＮＵＴＥＣ ＳＰ１（商品名）を用いた。 Inulin lauryl carbamate was used as the polymer emulsifier. And, as this lauryl carbamate inulin, INUTEC SP1 (trade name) manufactured by Orafti was used.
また水溶性高分子としてはポリアクリル酸を用い、油性成分としてはスクワラン油を用い、多価アルコールとしては、グリセリンを用いた。さらに、ゲル架橋剤としてはメタケイ酸アルミン酸マグネシウムを用い、ゲル架橋速度調整剤としてはＥＤＴＡ−２Ｎａを用い、ｐＨ調整剤としては酒石酸を用い、防腐剤としてはメチルパラベンを用いた。 Polyacrylic acid was used as the water-soluble polymer, squalane oil was used as the oil component, and glycerin was used as the polyhydric alcohol. Further, magnesium metasilicate aluminate was used as the gel crosslinking agent, EDTA-2Na was used as the gel crosslinking rate adjusting agent, tartaric acid was used as the pH adjusting agent, and methylparaben was used as the preservative.
比較例としては、上記高分子乳化剤に代えて、低分子の一般的な界面活性剤であるグリセリン脂肪酸エステルを配合し、他の組成を同じにしたものを用いた。 As a comparative example, instead of the above polymer emulsifier, a glycerin fatty acid ester, which is a low molecular weight general surfactant, was blended and the other compositions were the same.
実施例と比較例の貼付剤を不織布からなるシート基材上に塗布した。実施例の貼付剤は、シート基材上で好適にゲルを形成したが、比較例の貼付剤は、液状のままでゲルが好適に形成されず、シート基材の裏面側に、油性成分が滲出していた。このような試験結果から、比較的多量の油性成分（スクワラン油）と精製水とが混在している状態で、一般的な低分子界面活性剤を用いた場合には、好適にゲルを形成できないが、上記実施例の高分子乳化剤を用いることで、好適にゲルを形成させうることがわかった。 The patches of Examples and Comparative Examples were applied on a sheet substrate made of a nonwoven fabric. The patch of the example suitably formed a gel on the sheet base material, but the patch of the comparative example remained in a liquid state and the gel was not suitably formed, and the oil component was present on the back side of the sheet base material. It was exuding. From such a test result, when a general low molecular surfactant is used in a state where a relatively large amount of oil component ( squalane oil ) and purified water are mixed, a gel cannot be suitably formed. However, it was found that the gel can be suitably formed by using the polymer emulsifier of the above-mentioned Examples.
１…シート基材 ２…貼付剤
1 ...
Claims (6)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2006209987A JP4989938B2 (en) | 2006-08-01 | 2006-08-01 | Skin patch and skin patch sheet |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2006209987A JP4989938B2 (en) | 2006-08-01 | 2006-08-01 | Skin patch and skin patch sheet |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008037757A JP2008037757A (en) | 2008-02-21 |
| JP4989938B2 true JP4989938B2 (en) | 2012-08-01 |
Family
ID=39173195
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006209987A Active JP4989938B2 (en) | 2006-08-01 | 2006-08-01 | Skin patch and skin patch sheet |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP4989938B2 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009286769A (en) * | 2008-06-02 | 2009-12-10 | Toyo Aerosol Ind Co Ltd | Foam-forming aerosol composition |
| WO2018220926A1 (en) * | 2017-05-30 | 2018-12-06 | Ｎｉｓｓｈａ株式会社 | Microneedle patch and packing material for same |
| WO2021131032A1 (en) * | 2019-12-27 | 2021-07-01 | ニチバン株式会社 | Adhesive patch |
| CN114845706A (en) * | 2019-12-27 | 2022-08-02 | 日绊株式会社 | Adhesive tape agent |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01151523A (en) * | 1988-11-10 | 1989-06-14 | Yamanouchi Pharmaceut Co Ltd | 'shiun-ko' poultice and preparation thereof |
| JPH0971541A (en) * | 1995-07-04 | 1997-03-18 | Kowa Co | Hydrophilic tacky base |
| DE19607847C1 (en) * | 1996-03-01 | 1997-11-20 | Suedzucker Ag | Aliphatic carboxylic acid esters of inulin |
| EP0964054A1 (en) * | 1998-06-11 | 1999-12-15 | Tiense Suikerraffinaderij N.V. (Raffinerie Tirlemontoise S.A.) | Surface-active alkylurethanes of fructans |
| JP4275768B2 (en) * | 1998-06-18 | 2009-06-10 | 久光製薬株式会社 | Aqueous adhesive paste |
| JP2000053528A (en) * | 1998-08-10 | 2000-02-22 | Lion Corp | Skin patch composition |
| JP2000072619A (en) * | 1998-08-26 | 2000-03-07 | Nitto Denko Corp | Sheet-shaped wet pack agent |
| JP2002146100A (en) * | 2000-11-13 | 2002-05-22 | Nof Corp | Composition for hydrogel, hydrogel and use thereof |
| JP2005104859A (en) * | 2003-09-29 | 2005-04-21 | Kanae Technos:Kk | Gel sheet |
| JP2005104929A (en) * | 2003-10-01 | 2005-04-21 | Kanae Technos:Kk | Sheet for packing and method for producing the same |
| JP2006104170A (en) * | 2004-10-08 | 2006-04-20 | Lion Corp | Patch and method for producing the patch |
-
2006
- 2006-08-01 JP JP2006209987A patent/JP4989938B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2008037757A (en) | 2008-02-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US5643555A (en) | Surfactant-free water-in-oil emulsion | |
| KR101994619B1 (en) | Method for producing cosmetic composition having an oil phase in the form of particles, and cosmetic composition produced thereby | |
| ES2704061T3 (en) | Cosmetic product in the form of an oil-in-water emulsion | |
| KR20140109804A (en) | Liquid Crystal Emulsified Organogel Composition and Mask Pack using Thereof | |
| KR20010007444A (en) | High internal aqueous phase water-in-oil type emulsion cosmetic composition | |
| JP4989938B2 (en) | Skin patch and skin patch sheet | |
| US20130189210A1 (en) | Oil-in-water cosmetic | |
| EP2910244A1 (en) | Topical adhesive skin patch | |
| WO2006012723A1 (en) | A multiple emulsion excipient for cosmetic actives | |
| JPH0439312A (en) | Crosslinked acrylic acid polymer and cosmetic using the same | |
| KR100848879B1 (en) | Wax-free water-in-oil solid emulsion composition | |
| KR20200050665A (en) | A mask gel composition, mask pack sheet including the same and method for preparing the mask pack sheet | |
| KR102317099B1 (en) | Cosmetic composition designed for breaking up algin capsule using chelating effect polymer | |
| KR20220096736A (en) | Oil in water type cosmetic composition | |
| JP2024026824A (en) | Takanai oil phase oil-in-water emulsion composition | |
| CN112004518A (en) | Aerogels and their use in cosmetic applications | |
| US20240156694A1 (en) | Multilayer emulsion cosmetic composition | |
| JP2013091619A (en) | Cosmetic | |
| JP2007204399A (en) | Water-in-oil emulsion composition | |
| CN101485616B (en) | Cracking lotion | |
| JP3105302B2 (en) | Cream base | |
| KR102458175B1 (en) | Oil in Water type cosmetic composition | |
| CN1248674C (en) | Oil-in-water type emulsion composition and method for producing emulsion composition | |
| TW202015648A (en) | Oil-in-water emulsified composition and its manufacturing method | |
| JP2006151851A (en) | Emulsion composition |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A711 | Notification of change in applicant |
Free format text: JAPANESE INTERMEDIATE CODE: A711 Effective date: 20080411 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20080411 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20090527 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20120124 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20120127 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20120327 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20120413 |
|
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20120501 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 4989938 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20150511 Year of fee payment: 3 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |