JP5022622B2 - Oral composition - Google Patents

Description

  The present invention relates to a composition for oral cavity having good adhesion to gums, teeth, etc. and high retention in the oral cavity.

  An oral composition represented by a dentifrice is used for the purpose of cleaning teeth and gums, purifying and refreshing the mouth, and preventing cavity and periodontal diseases. Therefore, various components such as abrasives, bactericides, tooth strengthening agents, vitamins, and tooth whitening agents are blended in the oral composition depending on the purpose to be prevented. In order to sufficiently exert the effects of these components, it is important to retain the oral composition for a long time in the teeth and gums in the oral cavity.

In order to improve the retention in the oral cavity of the oral composition, it is common to adjust physical properties such as the viscosity of the composition. For example, various binders are blended. As such a binder, sodium alginate, xanthan gum, hydroxypropyl cellulose, hydroxyethyl cellulose, carrageenan, carboxymethyl cellulose and the like are used (Patent Documents 1 to 3).
JP-A-7-187975 Japanese Patent Application Laid-Open No. 11-1418 JP 2002-47160 A

However, if the amount of the binder is increased in order to increase the retention in the oral cavity of the composition, the viscosity of the composition increases, and even if the retention is improved, the extrudability from the container is improved. There was a possibility that problems such as worsening and uncomfortable polishing could occur. In addition, even if the composition itself has a high adhesive force, it is applied to the oral cavity at the time of use, and when diluted with saliva, the adhesive force decreases, and sufficient oral retention is maintained under actual use conditions. Often does not have sex.
Accordingly, an object of the present invention is to provide a composition for oral cavity that does not decrease adhesion even when diluted with saliva when applied in the oral cavity, has excellent oral retention, and good usability such as extrudability. It is to provide.

  Therefore, the present inventors have prepared a composition in which a plurality of binder components are combined, and have studied the retention in the oral cavity. In addition to alginic acid or a salt thereof and xanthan gum, κ-carrageenan is combined and blended. In some cases, the tensile strength is 1.5 times diluted with artificial saliva containing potassium ions and calcium ions and measured with a force gauge, and when it is actually diluted with human saliva, it adheres to the gums and teeth. It was found that a composition for oral cavity with a good sensation, a good retention in the oral cavity and a good feeling in use can be obtained.

  That is, the present invention is an oral composition containing alginic acid or a salt thereof, xanthan gum and κ-carrageenan, wherein the mass ratio of alginic acid or a salt thereof to κ-carrageenan in the composition is (alginic acid or a salt thereof / κ). -Carrageenan)> 1, the water content is 5 to 35% by mass, and the composition is diluted 1.5 times with artificial saliva containing potassium ions and calcium ions, and a tensile strength test is performed using a force gauge. When performed, an oral composition having a tensile strength of 0.5 to 2 N is provided.

  The oral composition of the present invention, when applied to the oral cavity, adheres to the teeth and gums for a long time even when diluted with saliva, and stays in the oral cavity appropriately. The effects of the components are fully exhibited. Moreover, although the composition for oral cavity of this invention is excellent in the adhesiveness with respect to a tooth | gear or a gum, a viscosity is not especially high, and a usability | use_condition and the extrudability from a container are also favorable.

  The composition for oral cavity of the present invention contains 3 components of alginic acid or a salt thereof, xanthan gum and κ-carrageenan. Examples of the alginic acid salt include alkali metal alginates such as sodium alginate and potassium alginate, and sodium alginate is particularly preferable.

  In the present invention, κ type (κ-carrageenan) is particularly used among a plurality of carrageenans. Ι-Carrageenan is widely used in oral compositions, but when ι-carrageenan is used, the adhesion decreases when diluted with saliva, which is sufficient for actual use in the oral cavity. It was found that adhesion could not be obtained. On the other hand, κ-carrageenan has superior retention in the oral cavity compared to ι-carrageenan.

  The mass ratio of alginic acid or a salt thereof and κ-carrageenan to be blended in the oral composition of the present invention is (alginic acid or a salt thereof / κ-carrageenan)> 1 from the viewpoint of oral retention and use feeling. Is required, and is particularly preferably 1.6 or more.

  The water content in the composition for oral cavity of the present invention is required to be 5 to 35% by mass from the viewpoint of retention in the oral cavity and feeling of use, but is further 10 to 30% by mass, particularly 15 to 25% by mass. % Is preferred.

  The oral composition of the present invention has a tensile strength of 0.00 when the composition is diluted 1.5 times with artificial saliva containing potassium ions and calcium ions and a tensile strength test is performed using a force gauge. 5 to 2N. The state diluted 1.5 times with artificial saliva assumes that the composition has been diluted with saliva when actually applied to the oral cavity. It shows that it has sufficient adhesion. The tensile strength at 1.5 times dilution is 0.5 to 2N, but 0.5 to 1.8N, particularly 0.6 to 1.5N is preferable from the viewpoint of sufficient adhesion at the time of use.

  The tensile strength was obtained by mounting 0.03 g of a composition diluted 1.5 times with artificial saliva having the composition shown in Table 1 below between a plastic plate and a hydroxyapatite disk and compressing the composition to a width of 0.2 mm. It can be obtained by measuring the adhesive force, which is the value at the time of gradually pulling apart with a force gauge. When the said tensile strength is 0.5-2N, it has sufficient adhesive force at the time of use irrespective of the tensile strength of the composition itself, and the residence property in an oral cavity is also very favorable.

  The oral composition of the present invention can further contain silica. The silica may be water-insoluble silica that can be used in the composition for oral cavity, and any of thickening silica and abrasive silica may be used, and both may be included. As the thickening silica, colloidal silica, porous fine powder silica, ultrafine fine powder silica, gas phase method silica, etc. can be used, such as nip seal (Nippon Silica Kogyo Co., Ltd.), Silopure (Fuji Silysia Chemical Ltd.) ), Thixosyl (Rhodia Nikka Co., Ltd.), Toxeal (Tokuyama Co., Ltd.), sorbosyl (Ineos Silicas), and the like. Examples of the abrasive silica include precipitated silica, silica gel, aluminosilicate, silconosilicate, gluconosilicate and the like. The content of silica is preferably 0 to 15% by mass, particularly preferably 0 to 12% by mass from the viewpoint of retention in the oral cavity.

  In the composition for oral cavity of the present invention, the content of alginic acid or a salt thereof, xanthan gum and κ-carrageenan is such that the tensile strength when diluted 1.5 times with the ion-containing artificial saliva is 0.5 to 2N. What is necessary is just to mix | blend with. Alginic acid or a salt thereof is 0.5 to 2.5% by mass, more preferably 0.7 to 2% by mass, particularly 1 to 1.5% by mass in the oral composition from the viewpoint of retention in the oral cavity and feeling of use. % Content is preferable. In addition, xanthan gum is 0.2 to 1% by mass, more preferably 0.3 to 0.8% by mass, particularly 0.4 to 0.6% by mass in the oral composition in terms of retention in the oral cavity and usability. % Content is preferable. Moreover, (kappa) -carrageenan is 0.1-0.5 mass% in the composition for oral cavity from the point of an oral cavity retention property and a usability | use_condition, 0.15-0.45 mass%, especially 0.2. It is preferable to contain -0.4 mass%.

  Since the oral composition of the present invention has excellent retention in the oral cavity when applied to the oral cavity, in addition to the toothpaste composition, the composition for oral application, the liquid toothpaste composition, and the transparent gel It is useful as a composition. The viscosity of the composition for oral cavity of the present invention is preferably 1500 to 5000 dPa · s, more preferably 2000 to 4500 dPa · s, particularly 2500 to 4000 dPa · s from the viewpoint of extrudability from a container and usability.

  In addition to the above components, the oral composition of the present invention may contain an abrasive (other than silica), a wetting agent, a surfactant, a medicinal component, a flavoring agent, a coloring agent, a preservative and the like. Examples of the abrasive other than silica include calcium carbonate, calcium hydrogen phosphate, calcium pyrophosphate, aluminum hydroxide, alumina, magnesium carbonate, and magnesium phosphate.

  Examples of the wetting agent include glycerin, sorbitol, propylene glycol, polyethylene glycol, xylitol, maltitol, and lactol. These humectants are contained in the composition for oral cavity of the present invention in an amount of 1 to 80% by mass, more preferably 10 to 75% by mass, especially 20 to 70% by mass, in order to give the composition a gloss or to improve the storage stability. Is preferred.

As the surfactant, an anionic surfactant, a cationic surfactant, a nonionic surfactant, and the like can be blended. Specifically, C ₈ -C ₂₄ alkyl sulfate, α-olefin sulfonate, N— Acyl sarcosinate, N-acyl glutamate, 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine, N-acyl taurate, sucrose fatty acid ester, alkylol amide, polyoxyethylene hydrogenated castor oil, Examples include polyglycerin fatty acid ester, pluronic, polyoxyethylene sorbitan monostearate and the like. These surfactants are contained in the composition for oral cavity of the present invention in an amount of 0 to 5% by mass, further 0.1 to 3% by mass, particularly 0.3 to 2% by mass in terms of foamability and detergency. Is preferred.

  Various medicinal ingredients include fluorides such as sodium fluoride, potassium fluoride, ammonium fluoride, stannous fluoride and sodium monofluorophosphate; water-soluble phosphate compounds such as potassium salt and sodium salt of orthophosphoric acid Allantochlorohydroxyaluminum, hinokitiol, ascorbic acid, lysozyme chloride, glycyrrhizic acid and its salts, sodium chloride, malic acid, tranexamic acid, epsilon aminocaproic acid, dl-tocopherol acetate, α-bisabolol, isopropylmethylphenol, chlorohexidine salts, chloride Copper compounds such as cetylpyridinium, triclosan, azulene, glycyrrhetinic acid, copper chlorophyllin sodium, copper gluconate, aluminum lactate, strontium chloride, potassium nitrate, berberine, Roxamic acid and its derivatives, sodium tripolyphosphate, zeolite, dextranase, mutanase, amylase, methoxyethylene, maleic anhydride copolymer, polyvinylpyrrolidone, epidihydrocholesterin, benzethonium chloride, dihydrocholesterol, trichlorocarbanilide, citrate Examples include extracts of zinc acid, soft sugar beet extract, buckwheat extract, clove, rosemary, hornon, safflower and the like. These medicinal ingredients are preferably contained in the composition for oral cavity of the present invention within a range that does not interfere with the effects of the present invention.

  Examples of the flavoring agent include terpenes such as l-menthol, carvone, anethole and limonene. Examples of the preservative include paraoxybenzoic acid ester and sodium benzoate.

(1) Adhesion test (Adhesion evaluation 1 and 2)
0.03 g of sample or 0.03 g of sample diluted 1.5 times with artificial saliva having the composition shown in Table 1 between the plastic plate (acrylic plate) and hydroxyapatite disc (10 mm × 10 mm) of the apparatus of FIG. Mount on. The sample is compressed with a digital force gauge (A & D Co., Ltd.) until the sample interval between the plastic plate and the hydroxyapatite disk is 0.2 mm wide. Thereafter, the sample was pulled up with a digital force gauge of 0.2 mm / s, and the strength when the sample was pulled apart was measured. The results (average value of N = 3) are shown in Table 2.

(2) Adhesion test (residence evaluation)
Mount 0.3 g of a sample diluted 1.5 times with whole human saliva on a glass plate, and tilt the glass plate vertically. The time required for the flow front (starting point) of the sample to reach 3 cm was measured and used as an index of adhesion. Table 2 shows the time (average of N = 3) taken from the start point to a distance (end point) of 3 cm.

(3) Feeling of use A 1.0 g sample was applied to a toothbrush and polished for 3 minutes. Evaluation was made according to the following criteria, and the average values of three subjects were shown in Table 2.

4: There is a considerable stagnation 3: Slight stagnation 2: Little stagnation 1: No stagnation

(4) Extrudability test The sample was filled in a toothpaste standing tube having an exit diameter of 8.0 mm and a length of 16.5 cm, and a 7.5 cm portion was pushed from the tip, and 1.5 cm of paste emerged from the exit. The extrusion pressure of was measured. The measurement was performed at 25 ° C.

(5) Viscosity The viscosity (25 ° C.) of the sample one day after production was measured with a helipath viscometer DVR-BII (Toki Sangyo Co., Ltd.) under the conditions of rotor C, 2.5 r / min, and 1 minute.

Examples 1-6 and Comparative Examples 1-3
The toothpastes with the formulations shown in Table 2 were produced and evaluated for adhesive strength, retention in the oral cavity, feeling of use, extrusion property and viscosity. The results are shown in Table 2.

As is apparent from Table 2, a composition having a tensile strength of 0.5 N or more when diluted 1.5 times with artificial saliva containing potassium ions and calcium ions is actually adhesive when diluted with human saliva. Was very good.
Moreover, when content of water exceeds 35 mass% (Comparative Example 1), when κ-carrageenan is more than alginate (Comparative Example 2) and when κ-carrageenan is not included (Comparative Example 3), The usability in the oral cavity was poor.

Example 2 and Comparative Examples 4-6
Toothpastes with the formulations shown in Table 3 were prepared, and adhesion evaluations 1 and 2 were evaluated in the same manner as in Examples 1 to 6, and the feeling of use and extrudability. Note that Example 2 in Table 3 is the same as Example 2 in Table 2.

  As is apparent from Table 3, when ι-carrageenan was added, sufficient adhesion was not obtained as compared with the case where κ-carrageenan was added.

It is a schematic explanatory drawing of the apparatus used for an adhesive force test (adhesion evaluation 1 and 2).

Claims (2)

An oral composition containing alginic acid or a salt thereof 0.5 to 2.5% by mass , xanthan gum 0.4 to 1% by mass , κ-carrageenan 0.3 to 0.5% by mass, and thickening silica. The mass ratio of alginic acid or a salt thereof to κ-carrageenan in the composition is (alginic acid or a salt thereof / κ-carrageenan)> 1, the content of thickening silica is 6 to 15% by mass, and the water content Is 5 to 35% by mass, and the composition is diluted 1.5 times with artificial saliva containing potassium ions and calcium ions, and the force gauge is pulled up at 0.2 mm / s and a tensile strength test is performed. An oral composition having a tensile strength of 0.5 to 2N. The oral composition of claim 1 wherein the toothpaste composition.