JP5023366B2 - Mosquito coils and methods for stabilizing drugs in mosquito coils - Google Patents

Description

  The present invention relates to a mosquito coil, and more particularly to a mosquito coil that has an excellent effect of keeping the drug stable even if charcoal powder is contained as a base material, and a method for stabilizing the drug in the mosquito coil.

Mosquito coils are made by adding plant powder, chemicals, fragrances, etc., adding water, kneading, molding and drying. The plant powder blended in the mosquito coil is widely used as a base material because of its stable supply and low cost, but it needs to be improved because it generates a large amount of smoke during combustion.
Such smoke problems are observed not only in mosquito coils, but also in incense sticks such as Buddhist affairs, and various means for improving are being studied. For example, the thing which suppressed generation | occurrence | production of the smoke at the time of combustion by using charcoal powder instead of plant powder is known (for example, refer patent document 1).
As in the prior art, charcoal powder is suitable as a base material for suppressing the generation of smoke, but because charcoal powder has adsorption power, when used as a base material for mosquito coils, time There is a problem in that the drug is adsorbed and decomposed as time passes, and the insecticidal effect is reduced.

JP-A-8-81347 (page 1-3)

  Therefore, the present invention provides a mosquito coil that can keep the drug stable even if it contains charcoal powder as a base material, and a method for stabilizing the drug in the mosquito coil.

As a result of intensive studies to solve the above-mentioned problems, the present inventors have found that in mosquito coils containing charcoal powder as a base material, the adsorption and decomposition of the drug is suppressed by blending polyalkylene glycol, over a long period of time. The present inventors have found that the drug can be kept stable and have reached the present invention.
That is, this invention is achieved by the stabilization method of the chemical | medical agent in the mosquito coil incense of the following (1)-( 4 ) and the mosquito coil incense of ( 5 ).
(1) A mosquito coil which contains charcoal powder as a base material and a polyalkylene glycol as a stabilizer in a mosquito coil which contains a pyrethroid compound as a drug .
(2) The mosquito coil incense according to (1), wherein the polyalkylene glycol has a molecular weight of 200 to 20,000.
(3) the amount of the polyalkylene glycol, and wherein 1 to 15% by weight relative charcoal powder (1) or (2) above, wherein the mosquito Tosen incense.
(4 ) The mosquito coil incense according to any one of (1) to ( 3 ), characterized by being smokeless or slightly smoked incense.
(5) charcoal powder containing as a base material, a mosquito coil containing the pyrethroid compound as a medicament, the stabilizing method of the drug in mosquito coils, which comprises blending a polyalkylene glycol as a stabilizer .

By this invention, even if it is a mosquito coil which contains charcoal powder as a base material, a chemical | medical agent can be kept stable over a long period of time. Thereby, it is possible to provide a mosquito coil incense as smokeless or fine smoke incense that does not reduce the insecticidal effect even when stored for a long time.

In the mosquito coil of the present invention, polyalkylene glycol is blended as a stabilizer. Thereby, the chemical | medical agent in a mosquito coil can be kept stable. The molecular weight of the polyalkylene glycol is 200 to 20000, preferably 200 to 6000. The alkylene chain preferably has 2 to 4 carbon atoms, and may be linear or branched, but is preferably linear. Specifically, polyethylene glycol, polypropylene glycol, polytetramethylene glycol and the like are used, polyethylene glycol and polypropylene glycol are preferable, and polyethylene glycol is particularly preferable. Moreover, 1 type, or 2 or more types of various polyalkylene glycol can also be used in combination.
What is necessary is just to mix | blend so that a compounding quantity may be 1-15 weight% with respect to the charcoal powder contained in the mosquito coil, and preferably 2-10 weight%. Moreover, what is necessary is just to mix | blend so that it may become 1 to 10 weight% with respect to the total amount of mosquito coils, and preferably 1 to 7 weight%. If the amount is too small, the drug may not be kept stable. Moreover, when too much, the intensity | strength of an incense stick will fall and it will become easy to break.

Examples of the charcoal powder used in the mosquito coil of the present invention include pine, cedar, cypress, basamushi, oak, kunugi, oak, itaya maple, rubber, lawan, mitsumata, oga, bamboo, palm, etc. One or a combination of two or more charcoal charcoal such as black charcoal, white charcoal, and bincho charcoal carbonized at a constant temperature of ˜1000 ° C. can be used.
Here, the charcoal preferably has a specific surface area of about 200 to 400 m ² / g and a pore volume of about 0.1 to 3 ml / g, such as oak black charcoal, oak white charcoal, bamboo charcoal (above, Kochi). , Oak white charcoal (Oita), Ubmegashi Bincho charcoal (from Wakayama), Kunugi black charcoal, bamboo charcoal (from Fukushima), oak black charcoal, itayakaede black charcoal (from Iwate), rubber black charcoal, lawan black charcoal, coconut shell charcoal ( These include: Malaysian), Mitsumata Black Charcoal (Tokushima), Oga Charcoal (from Hiroshima), Oga Charcoal, Hinoki Black Charcoal (from Nara), Coconut Shell Charcoal (from the Philippines), Sugi Black Charcoal (from Hyogo), etc. . The production area is not limited to these.
And when making into charcoal powder, it is preferable that the particle size is about 40 to 350 μm because there is no rise during manufacture and the strength of the mosquito coil can be secured.

  In the mosquito coil of the present invention, in order to adjust the amount of smoke generated during combustion to make smokeless or fine smoke, the charcoal powder is 20 to 90% by weight, preferably 25 to 80% by weight, based on the base material. To contain. If the amount of charcoal powder is too small, the generation of smoke during combustion cannot be sufficiently suppressed. On the other hand, when the amount is too large, coloring may be deteriorated and the product value may be impaired, or the strength of the mosquito coil may be lowered and easily broken.

  In the mosquito coil of the present invention, smokeless or fine smoke means that the measured value with a dust meter is 300 (cpm) according to the method for measuring the amount of smoke during combustion described in the following examples. In the following, it means preferably 250 (cpm) or less.

The mosquito coils of the present invention can contain one or more of various insecticides and repellent components as a drug. For example, insecticide chrysanthemum extract, natural pyrethrin, praretrin, imiprothrin, phthalthrin, allethrin, transfluthrin, resmethrin, phenothrin, ciphenothrin, permethrin, cypermethrin, etofenprox, cyfluthrin, deltamethrin, bifenthrin, fenpropathrin, empensrin Pyrethroid compounds such as silafluophene, metfurflurin, profluthrin; organophosphorus compounds such as fenitrothion, diazinon, marathon, pyridafenthione, prothiophos, phoxime, chlorpyrifos, dichlorvos; carbamate compounds such as carbaryl, propoxur, mesomil, thiodicarb; Diazole compounds; phenyl such as fipronil Razole compounds; sulfonamide compounds such as amidoflumet; neonicotinoid compounds such as dinotefuran and imidacloprid; insect growth control compounds such as metoprene, hydroprene and pyriproxyfen; pyrrole compounds such as chlorfenapyr; benzyl alcohol, mint oil Insecticidal essential oils such as: Diet, di-n-butylsuccinate, hydroxyanisole, ethyl-butylacetylaminopropionate, p-menthane-3,8-diol, citronella oil, eucalyptus oil, geranium oil, moon peach Examples include repellents such as oil and mosquito reeds.
Among these, pyrethroid compounds are preferable, and natural pyrethrin, allethrin, insect repellent chrysanthemum extract, transfluthrin, metfurthrin, profluthrin, and empensulin are preferable for use as mosquito coils.
These chemicals may be contained in the mosquito coil so as to be 0.05 to 1% by weight, preferably 0.1 to 0.5% by weight.

The mosquito coil of the present invention is manufactured by uniformly kneading the above polyalkylene glycol, charcoal powder, and drug together with a binder, etc., and then molding into a predetermined shape such as a spiral, rod, or spiral. That's fine. Alternatively, a predetermined shape may be made only with a base material in advance, and a drug may be applied and impregnated into the shape. At this time, inorganic and organic solvents, emulsifiers, solubilizers and the like may be used as necessary.
At the time of manufacture, inorganic powders such as pearlite (pearlite, obsidian, pine sebite, etc. baked and expanded), radiolite (diatomaceous earth), white carbon (silicic acid), calcium carbonate; cedar, camphor, mominoki, sandalwood Tree powder such as spruce and birch; plant powder such as pesticide chrysanthemum extract powder (rice cake powder) and coconut powder; celluloses such as carboxymethylcellulose, hydroxymethylcellulose, hydroxypropylmethylcellulose, taboo peel extract powder (tab powder), starch, starch Such as starches, natural polymer compounds such as gum arabic, synthetic polymer compounds such as polyvinyl alcohol, polyvinylpyrrolidone, etc .; auxiliary agents such as potassium nitrate and lead acetate; solvents such as ethanol, kerosene, water, etc. Can be used.

  In addition to these, efficacy enhancers such as piperonyl butoxide, N-propyl isome, MGK-264, cinepirin 500, Leesen 384, IBTA, S-421; phenethyl isothiocyanate, dimethyl high mix acid Volatilization rate improvers such as potassium nitrate and manganese dioxide; POE sorbitan fatty acid esters, POE alkyl ethers, POE hydrogenated castor oil and other surfactants; isopropylmethylphenol, p-hydroxybenzoate ester, PCMX, IPBC, chlorhexidine gluconate, chlorhexidine hydrochloride , Disinfectants such as sorbic acid, dehydroacetic acid and their salts; deodorants such as lauryl methacrylate, geranyl chloride, catechin, polyphenol; dyes such as macalide green and various legal dyes; α-pinee , Β-pinene, limonene, linalool, l-menthol, d-menthol, dl-menthol, eugenol, lavender, citral, citronellal, cara, sandalwood, green tea, mugue, bamboo, leafy green, hinoki, plum, eucalyptus Perfumes such as white peach and cherry may be added.

EXAMPLES The present invention will be described in more detail with reference to examples below, but the present invention is not limited to these examples.
Test example 1
Charcoal powder 45% by weight, wood powder (tab powder) 17% by weight, inorganic powder (mixture of calcium carbonate and diatomaceous earth) 21.3% by weight and binder (mixture of sodium salt of carboxymethyl cellulose and corn starch) 13% by weight Used in a mortar and mixed well. Next, 0.25% by weight of a drug (aresulin), 0.1% by weight of a surfactant (POE sorbitan fatty acid ester), and 0.35% by weight of a preservative (sodium dehydroacetate) were dispersed in a small amount of water. In addition, 3% by weight of the components listed in Table 1 (corresponding to about 6.67% by weight with respect to charcoal powder) was dissolved in an appropriate amount of warm water and added.
After thoroughly mixing the raw materials composed of the above components, it is extruded from a nozzle so as to have a cross section of 6 mm × 4 mm and a length of 400 mm with a hydraulic press, and is placed on a net, and is about 6 hours under a slight wind of 60 ° C. Dried to produce a stick-shaped mosquito coil.
Using the rod-shaped mosquito coils in this way, the test was conducted as follows.

● Residual rate of drug during long-term storage A long-term storage was reproduced by an accelerated test (equivalent to 8 months at room temperature) where a rod-shaped mosquito coil was placed in a resin film bag and left at 50 ° C for about 1 month. After leaving it under these conditions, the mosquito coils were crushed and the alleles were extracted and quantified by gas chromatography (Shimadzu Corporation GC-17) to calculate the residual rate (%). The test was repeated three times and the average value was determined.
● Smoke amount during combustion After placing a rod-shaped mosquito coil in a glass chamber (70 cm × 70 cm × 70 cm) and burning it for 30 seconds, the incense was taken out and the air in the chamber was stirred with a fan for 30 seconds. Then, the dust in the chamber was sucked and collected for 1 minute using a dust meter (Shibata Digital Dust Indicator P-5), and the dust concentration (cpm) was measured. The test was repeated three times and the average value was determined.
● Test results The test results are shown in Table 1. By blending polyethylene glycol and polypropylene glycol, the remaining rate of allesrin is maintained at 96 to 100% with respect to the initial value, and even if stored for a long time, allesulin (drug) is not reduced by adsorption, decomposition, It was shown that the amount of smoke was also suppressed. In particular, polyethylene glycol was excellent with little odor during combustion.
When other ingredients were blended, the residual rate of allethrin was greatly reduced, and there was concern about the reduction of the insecticidal effect, and the smoke amount was increased. In the table, polyethylene glycol having a molecular weight of X is described as “PEG X”.

Test example 2
A spiral mosquito coil made of the raw materials listed in Table 2 was produced using a spiral incense maker. In the same manner as in Test Example 1, the remaining rate (%) of allethrin and the smoke amount (cpm) were measured. The test was repeated three times and the average value was determined. In addition, allethrin volatilized during combustion was collected for 2 hours using a silica gel trap, and analyzed by gas chromatography (Shimadzu Corporation GC-17) to calculate the volatility (%) of alleslin. The test was repeated twice to obtain an average value.
The test results are shown in Table 3. It was shown that by adding polyethylene glycol, the amount of smoke increased slightly, but the remaining rate and volatilization rate of allethrin were clearly improved.

Test example 3
In the rod-shaped mosquito coil of Example 2, the ratio (% by weight) of polyethylene glycol to charcoal powder was increased or decreased, and the remaining rate of allethrin was examined in the same manner as in Test Example 1. The increase / decrease in polyethylene glycol was balanced by the amount of tab powder.
The test results are shown in Table 4. The residual rate of alleslin tended to depend on the blending amount of polyethylene glycol, and in particular, the residual rate was high at 2.2% by weight or more and the stability effect was excellent.

Test example 4
A spiral mosquito coil with the composition shown in Table 5 was produced using a spiral incense maker. Table 6 shows the types of fragrances used for the incense sticks.
Each incense stick was checked for odor after burning for 30 minutes in a 6 tatami test room under no-wind conditions, and sensory evaluation was performed by three testers for the presence or absence of smoke odor. The results are shown in Table 6.

  From the result of Table 6, it became clear that the mosquito coil incense stick of this invention can further suppress a smoke smell by mix | blending a fragrance | flavor. In particular, green tea, muguet, bamboo, leafy green, hinoki and lavender were excellent in fragrance and good in usability.

Test Example 5
Among the incense sticks used in Test Example 4, the fragrances shown in Table 7 having excellent fragrance were further subjected to sensory evaluation for the presence or absence of smoke odor as in Test Example 4 except that 20 testers were used. The results are shown in Table 7.

  As shown in Table 7, 80% or more of the testers of the mosquito coil incense of the present invention did not feel smoke odor.

Test Example 6
A spiral mosquito coil was manufactured as a composition similar to Example 13 and Comparative Example 10 of Test Example 4 except that no fragrance was contained (Example 14, Comparative Example 11). The increase / decrease in the fragrance was balanced by the amount of wood flour.
And the smoke amount (cpm) at the time of combustion of each incense stick was measured by the method similar to Test Example 1. The results are shown in Table 8.

  From Table 8, the smoke amount of Example 14 was about a quarter of that of Comparative Example 11. Moreover, when burning the incense stick, Example 14 was in a state where almost no smoke was visually visible. Thereby, it was shown that the mosquito coil of this invention is the outstanding thing which can reduce generation | occurrence | production of smoke.

Test Example 7
About the spiral mosquito coil incense stick manufactured in Test Example 6 (Example 14, Comparative Example 11), the amount of tar generated by each incense stick during combustion was measured by the following method.
(1) A glass fiber filter (diameter 47 mm) was attached to a triangular funnel.
(2) An incense stick (one volume) was burned and the smoke was collected on a filter.
(3) The tar amount was obtained by subtracting the weight of the glass filter before collection from the weight of the glass filter after collection.
The results are shown in Table 9. In addition, the test was performed twice and the average value was shown.

  As shown in Table 9, the amount of tar was also reduced in Example 14 compared to Comparative Example 11. Thereby, it was shown that the mosquito coil of the present invention is an excellent one that can reduce not only the generation of smoke but also the generation of tar.

Test Example 8
For the spiral mosquito coil incense manufactured in Test Example 6 (Example 14, Comparative Example 11), the amount of irritating substances (acetaldehyde, amines, phenol, acetic acid) generated by each incense when burning was measured.
As a test method, each incense stick was burned in a glass chamber (70 cm × 70 cm × 70 cm) for 5 minutes, and then the incense stick was taken out and the electric fan was turned on for 20 seconds. Then, it quantified with the gas detection pipe | tube (GASTEC gas detection pipe | tube made by Gastec). The results are shown in Table 10.

  As shown in Table 10, in Example 14, the amount of each irritating substance detected was significantly lower than that in Comparative Example 11. From this, it was revealed that the mosquito coil of the present invention is an excellent one that can effectively reduce generation of irritating substances in addition to reduction of generation of smoke and tar.

Claims (5)

A mosquito coil, which contains charcoal powder as a base material and contains a pyrethroid compound as a drug and polyalkylene glycol as a stabilizer.   The mosquito coil incense according to claim 1, wherein the polyalkylene glycol has a molecular weight of 200 to 20,000.   The amount of polyalkylene glycol blended is 1 to 15% by weight based on charcoal powder. The mosquito coil incense according to any one of claims 1 to 3, wherein the mosquito coil is a smokeless or a fine smoke incense. A method for stabilizing a drug in a mosquito coil, which comprises blending charcoal powder as a base material and a polyalkylene glycol as a stabilizer in a mosquito coil having a pyrethroid compound as a drug.