JP5025535B2 - Antibacterial agent composition and deodorant composition - Google Patents

Description

  The present invention relates to an antibacterial agent composition and a composition for a deodorant containing the antibacterial agent composition.

  It is said that body odor such as odor that gives a person unpleasant feeling is caused by sweat mixed with sebum, which is decomposed by odor-causing bacteria.

  Therefore, in order to suppress the generation of body odor, antibacterial compounds have been conventionally used in deodorant compositions (see, for example, Patent Documents 1 to 3).

  However, there are sweat glands and sebaceous glands in human skin, and the amount of sweat and sebum varies from time to time, and the antibacterial activity of antibacterial compounds may differ between the state where there is a lot of sweat (moisture) and the amount of sebum was there. Conventional deodorant compositions cannot cope with such changes in skin condition, and have a problem in that the deodorant / deodorant effect cannot be sufficiently exhibited. Furthermore, there has been a problem that the deodorizing / deodorizing effect cannot be obtained continuously due to changes in the skin condition.

  On the other hand, by using triclosan and isopropylmethylphenol in combination, a deodorant agent has been reported that can maintain antibacterial activity against odor-causing bacteria even in a skin state that secretes a lot of sebum in addition to a skin state that secretes a lot of sweat (patent) (Ref. 4).

  However, the above-described technology has been limited to the ability to maintain antibacterial activity against odor-causing bacteria even in different skin conditions, and has not been able to synergistically enhance antibacterial activity. Therefore, development of a composition for a deodorant capable of exhibiting a deodorizing / deodorizing effect more effectively even in various skin conditions is desired.

JP 2002-80335 A JP 2003-81801 A JP 2004-189633 A JP 2006-96719 A

  The present invention has been made in view of the above prior art, and is used in combination with azulene sulfonate, so that triclosan or isopropylmethylphenol has antibacterial properties even in various skin conditions with different amounts and ratios of sweat and sebum. It is an object of the present invention to provide an antibacterial composition capable of enhancing the activity, and a composition for a deodorant containing the antibacterial composition.

That is, the present invention
[1] An antibacterial agent composition containing azulene sulfonate, triclosan and / or isopropylmethylphenol, and [2] an antibacterial agent composition described in [1] above. The present invention relates to a deodorant composition.

  The antibacterial agent composition according to the present invention can enhance the antibacterial activity inherent to triclosan or isopropylmethylphenol even in various skin conditions with different amounts and ratios of sweat and sebum when used in combination with azulene sulfonate. There is an effect that can be done.

  In addition, since the antibacterial agent composition according to the present invention exhibits excellent antibacterial activity against odor-causing bacteria in various skin conditions, the deodorant composition containing the composition has an excellent deodorizing effect. Demonstrate.

  The antibacterial agent composition according to the present invention contains azulene sulfonate and triclosan and / or isopropylmethylphenol as essential components.

  Azulene sulfonate is a sulfonate of guaiazulene (7-isopropyl-1,4-dimethylazulene) and is a substance having an anti-inflammatory action. Also called water-soluble azulene or guaiazulene sulfonate.

  The salt of azulene sulfonic acid is not particularly limited, and examples thereof include sodium salts, potassium salts, ammonium salts, and the use of sodium salts is preferred.

  Triclosan is trichlorohydroxydiphenyl ether and is a fungicide with a broad antibacterial spectrum.

  Isopropylmethylphenol (hereinafter abbreviated as IPMP) is a bactericidal agent obtained by reacting metacresol and isopropyl chloride or isopropyl alcohol and having bactericidal properties and weak astringency.

  In the antibacterial agent composition according to the present invention, the contents of the first component, azulene sulfonate, and the second component, triclosan and / or IPMP, are not particularly limited. The blending ratio is 1: 1 to 10: 1, more preferably 0.2: 1 to 5: 1, and still more preferably 0.5: 1 to 2: 1. When the content of the first component exceeds 10 parts by weight of the second component, and less than 0.1 parts by weight, the antibacterial activity enhancing effect cannot be expected, which is not preferable.

  In addition to the first component and the second component, the antibacterial agent composition of the present invention includes a solvent, a surfactant, an antioxidant, a sequestering agent, etc., as long as the effects of the present invention are not impaired. It can mix | blend suitably.

  The antibacterial agent composition of the present invention can be used by blending with a deodorant composition. Although the compounding quantity is not specifically limited, 0.001 to 3 weight% in a composition for deodorants, Preferably it is 0.01 to 2 weight%, More preferably, it is good to set it as 0.1 to 1 weight%. When the blending amount is less than 0.001% by weight, the antibacterial effect is inferior. When the blending amount exceeds 3% by weight, there may be a problem in safety such as skin irritation. It is not preferable.

  Moreover, an antiperspirant component and a deodorant component can be further mix | blended with the composition for deodorizers of this invention.

  Antiperspirant component is a drug that suppresses the generation of sweat by converging the skin. For example, aluminum chloride, aluminum potassium sulfate, aluminum sulfate, aluminum acetate, chlorohydroxyaluminum, allantoin chlorohydroxyaluminum, paraphenolsulfonic acid Zinc and the like can be exemplified.

  The blending amount of the antiperspirant component is not particularly limited as long as the effect of the present invention is exerted, and is preferably 0.1 to 20% by weight, more preferably 0.3 to 15% by weight in the deodorant agent. . If the blending amount is less than 0.1% by weight, the durability of the deodorizing / deodorizing effect is inferior. If the blending amount exceeds 20% by weight, safety problems such as skin irritation may occur. In either case, it is not preferable.

  A deodorant component is a chemical that has the effect of eliminating odors by reacting and adsorbing substances that emit odors or masking odors. For example, metal oxides such as zinc oxide, alkyldiethanolamide, hydroxy Examples include apatite, tea extract, fragrance, and antioxidant.

  The blending amount of the deodorant component is not particularly limited as long as the effect of the present invention is exhibited, and is preferably 0.01 to 5% by weight, and preferably 0.1 to 2% by weight in the composition for deodorant. Is more preferable. If the blending amount is less than 0.01% by weight, the effect of masking the odor is inferior. If the blending amount exceeds 5% by weight, the scent may become too strong or the skin may be colored. In any case, it is not preferable because safety problems such as skin irritation may occur.

  The deodorant composition of the present invention includes, in the range not inhibiting the effects of the present invention, lower alcohols such as ethanol and isopropyl alcohol; higher alcohols such as lauryl alcohol and stearyl alcohol; glycerin and diglycerin. Polyhydric alcohols such as dipropylene glycol, 1,3-butanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol, 1,2-decanediol; bentonite, carrageenan, carboxy Thickeners such as vinyl polymer and hydroxyethyl cellulose; antioxidants such as tocopherol and its derivatives, ascorbic acid and its derivatives; sequestering agents such as edetate, phosphoric acid and sodium polyphosphate; animal and plant extracts, citrus PH adjusters such as acid and tartaric acid; Recone acids, humectants, surfactants, preservatives, powders, coloring agents, can also be appropriately blended and water.

  Since the composition for deodorant of the present invention exhibits excellent antibacterial activity against the odor-causing bacteria, it is used as a deodorant / deodorant for shoes and boots, a deodorant / deodorant for feet and underarms, etc. be able to. Among them, since it exhibits excellent antibacterial activity even in various skin conditions with different amounts of sweat and sebum, it can be preferably used as a deodorant / deodorant for the body of feet, armpits and the like.

  In addition, the dosage form can be used in various forms such as lotion, aerosol, stick, powder, roll-on, cream, gel, emulsion, sheet, etc., and the formulation can be produced by a generally known method. That's fine.

<Test Example 1>
As test bacteria, Staphylococcus epidermidis IAM1296 and Corynebacterium minutisium ATCC23348, which are odor-causing bacteria, were used.

(Preparation of inoculum solution)
Staphylococcus epidermidis or Corynebacterium minutishimam was cultured at 35 ° C. on an agar medium as an inoculum and then transplanted to a bouillon medium and cultured at 35 ° C. A solution obtained by diluting the obtained culture solution with a bouillon medium to about 10 ⁷ cells / mL was used as a bacterial solution for inoculation.

(Preparation of dilution series)
Sodium azulenesulfonate (Comparative Example 1), Triclosan (Comparative Example 2), and IPMP (Comparative Example 3) were prepared to 3000 μg / mL using 70% ethanol as a diluent solvent, and diluted 10-fold to a dilution series. Was prepared.

  In addition, dilution series were similarly prepared for an equivalent mixture of sodium azulenesulfonate and triclosan (Example 1) and an equivalent mixture of sodium azulenesulfonate and IPMP (Example 2).

(Measurement of minimum bactericidal concentration (MBC))
For each 1 mL of the dilution series containing each test substance, 9 mL of each agar medium was placed in a petri dish. Culturing was performed at 35 ° C., and the presence or absence of bacterial growth after 5 days was determined. At a concentration at which no growth was observed at this time, the bacteria were collected from the inoculated streak, transplanted to a fresh agar medium, and further cultured for 3 days. At this time, the minimum concentration at which no growth was observed was determined as MBC, and the concentration of each component at that time was shown in Tables 1 to 4 (no addition of treolein).

(Examination of the effects of sebum components)
In order to examine the bactericidal effect due to the influence of sebum components, treolein was added as a sebum component and the following test was performed. That is, for each 1 mL of the dilution series containing each test substance, 0.5% by weight of triolein and 8.5 mL of agar medium were placed in a petri dish. I streaked. Culturing was performed at 35 ° C., and the presence or absence of bacterial growth after 5 days was determined. At a concentration at which no growth was observed at this time, the bacteria were collected from the inoculated streak, transplanted to a fresh agar medium, and further cultured for 3 days. At this time, the minimum concentration at which no growth was observed was determined as MBC, and the concentration of each component at that time was shown in Tables 1 to 4 (added with treolein).

  Tables 1 and 2 relate to Staphylococcus epidermidis, and Tables 3 to 4 relate to Corynebacterium minutishima.

  The antibacterial activity can be evaluated by MBC. When the test substance concentration is low, there is no effect on microorganisms, but as the concentration is increased, growth inhibition occurs, and then growth stops. As the concentration increases further, the microorganisms will die. The density at this time is expressed as MBC.

  From the results of Tables 1 and 3, almost no antibacterial activity was observed with sodium azulenesulfonate alone (Comparative Examples 1-1 and 1-2). In addition, triclosan alone (Comparative Examples 2-1 and 2-2) shows that MBC increases from 12 μg / mL to 750 μg / mL due to the presence of triolein, which is a sebum component, and the antibacterial activity is significantly reduced. In contrast, when sodium azulenesulfonate and triclosan were used in combination (Examples 1-1 and 1-2), MBC was remarkably low in the presence and absence of treolein, and the antibacterial activities of both were synergistic. It can be seen that it is significantly enhanced.

  Moreover, from the results of Tables 2 and 4, almost no antibacterial activity was observed with sodium azulenesulfonate alone (Comparative Examples 1-1 and 1-2). It can also be seen that IPMP alone (Comparative Examples 3-1 and 3-2) increases MBC and reduces antibacterial activity due to the presence of triolein, which is a sebum component. In contrast, when sodium azulenesulfonate and IPMP are used in combination (Examples 2-1 and 2-2), MBC is low in the presence and absence of treolein, and the antibacterial activity of both is synergistic. It can be seen that it is enhanced.

  As described above, from the results of Tables 1 to 4, the antibacterial agent composition of the present invention was originally used in combination with sodium azulene sulfonate so that each of triclosan or IPMP was originally in a skin state with a lot of sweat or a skin with a lot of sebum. It can be seen that the antibacterial effect possessed can be synergistically enhanced to exhibit excellent antibacterial activity against odor-causing bacteria in various skin conditions.

<Test Example 2>
(Sample preparation)
According to the composition described in Table 5, each deodorant composition of Examples 3-4 and Comparative Examples 4-6 was prepared by a conventional method and subjected to the following evaluation. In addition, the compounding quantity in a table | surface represents weight%.

(Test example: Evaluation of deodorant composition)
For 10 male subjects determined to have a strong odor, each sample was applied to one armpit of the subject, and the other armpit was not applied as a control. The odor was determined according to the following evaluation criteria before and immediately after application and after 3 hours, and the average value was adopted. The results are shown in Table 5.

<Evaluation criteria>
No odor ... 0 point Slightly smell ... 1 point Slightly weak smell ... 2 points Clear smell ... 3 points Very strong smell ... ... 4 points

  From the results of Table 5, it can be seen that the composition for deodorant of the present invention has an excellent deodorizing effect and the effect also lasts for a long time.

  Hereinafter, the formulation example of the composition for deodorants concerning this invention is shown. In addition, a compounding quantity is weight%.

(Formulation Example 1: Liquid deodorant)
Zinc paraphenol sulfonate 2.0
Ethanol 30.0
1,3-butylene glycol 3.0
Sodium azulene sulfonate 0.1
Isopropylmethylphenol 0.1
Polyoxyethylene (50) hydrogenated castor oil 0.5
Perfume
Purified water residue Total 100.0

(Formulation example 2: Deodorant spray)
Purified water 30.0
Ethanol 20.0
Sodium azulene sulfonate 0.2
Isopropylmethylphenol 0.1
Dimethyl ether 49.7
Total 100.0

(Formulation example 4: Deodorant stick)
Stearyl alcohol 25.0
Polyethylene glycol 10.0
Chlorohydroxyaluminum 20.0
Cyclic dimethylpolysiloxane 44.6
Triclosan 0.15
Sodium azulene sulfonate 0.15
Fragrance 0.1
Total 100.0

(Formulation Example 5: Deodorant Stick)
Isopropyl myristic acid ester 10.0
Sodium stearate 10.0
Cetanol 3.0
Propylene glycol 25.0
Sodium azulene sulfonate 0.2
Isopropylmethylphenol 0.1
Purified water 1.0
Ethanol residue
Perfume proper amount total 100.0

(Formulation Example 6: Roll-on deodorant)
Ethanol 30.0
Polyoxyethylene hydrogenated castor oil (40E.O.) 1.0
Chlorohydroxyaluminum 10.0
Hydroxypropyl methylcellulose 0.5
Triclosan 0.1
Sodium azulene sulfonate 0.1
Perfume
Purified water residue Total 100.0

(Prescription Example 7: Deodorant Mist)
Ethanol 45.0
Polyoxyethylene hydrogenated castor oil (50E.O.) 0.5
Zinc paraphenol sulfonate 0.3
Cross-linked polystyrene 5.0
Sodium azulene sulfonate 0.2
Isopropylmethylphenol 0.1
Perfume
Purified water Total remaining 100.0

(Prescription Example 8: Deodorant Gel)
Ethanol 60.0
Carboxyvinyl polymer 0.4
Cyclic silicone 1.0
Polyether-modified silicone 0.5
Sodium azulene sulfonate 0.1
Triclosan 0.2
Triethanolamine 0.4
Silicone powder 1.0
Perfume
Purified water Total remaining 100.0

Claims (4)

  An antibacterial composition comprising azulene sulfonate and triclosan and / or isopropylmethylphenol.   The antibacterial composition according to claim 1, which is used for an anti-odor odor-causing bacterium.   A deodorant composition comprising the antibacterial agent composition according to claim 1.   4. A deodorant composition according to claim 3, comprising an antiperspirant component and / or a deodorant component.