JP5105364B2 - Superconducting biomagnetic measuring device - Google Patents

Description

  The present invention relates to a superconducting biomagnetism measuring device, and more specifically, superconductivity capable of aligning the time phases of heartbeats of magnetocardiographic data collected at different positions at different times without providing an electrocardiograph. The present invention relates to a biomagnetic measurement device.

Conventionally, a biomagnetism measuring apparatus for small animals for measuring the magnetocardiogram of a small animal such as a mouse is known (for example, see Patent Document 1).
JP 2007-313152 A

  In order to create a magnetocardiogram (contour map), magnetocardiographic data collected at different positions at the same time is required. However, if magnetocardiographic data cannot be collected at different positions at the same time, they will differ. The magnetocardiographic data collected at different positions at different times are regarded as the magnetocardiographic data collected at different positions at the same time by aligning the time phases of the heart beats.

Conventionally, an electrocardiograph has been used to align the time phases of the heartbeat data of the magnetocardiographic data collected at different times at different positions. That is, when collecting magnetocardiographic data at different times and at different times, the electrocardiograph signal is used as a trigger for data collection, or the electrocardiograph data is collected and recorded in parallel with collecting the magnetocardiographic data. In the post-processing, the time phases for the heart beats of each magnetocardiographic data are aligned.
However, placing an electrocardiograph in the vicinity where a weak electrocardiogram is measured using a superconducting magnetic sensor as in the above-mentioned biomagnetism measuring apparatus for small animals, the electrocardiograph electrodes and wires become noise sources. There is a problem that measurement of weak magnetocardiograms is hindered.
Therefore, an object of the present invention is to provide a superconducting biomagnetometer capable of aligning the time phases of heartbeats of magnetocardiographic data collected at different positions at different times without providing an electrocardiograph. It is in.

  In the first aspect, the present invention provides at least one superconducting magnetic sensor (5a), superconducting magnetic sensor moving means (6, 7) for moving the superconducting magnetic sensor (5a), and the superconducting magnetic sensor. A data collecting means (20) that moves the sensor (5a) and collects magnetocardiographic data at two or more measurement positions, and detects the magnetocardiographic signal without being substantially affected by the movement of the superconducting magnetic sensor (5a). A superconducting biomagnetism measuring device (100), comprising: a magnetocardiogram detection sensor (5b) for performing the above-described operation; and trigger means (20) for controlling collection of the magnetocardiographic data using the magnetocardiogram signal as a trigger. provide.

In the above configuration, “one or more superconducting magnetic sensors (5a)” is, for example, one SQUID sensor or a plurality of SQUID sensors integrated on one substrate.
“Detecting a magnetocardiogram signal without being substantially affected by the movement of the superconducting magnetic sensor (5a)” means that the superconducting magnetic sensor (5b) is detected from the magnetocardiogram signal detected by the magnetocardiogram detection sensor (5b). This means that the phase of the heartbeat can be detected without being affected by the position 5a).
The magnetocardiogram detection sensor (5b) is, for example, one SQUID sensor, one fluxgate sensor, or a loop coil.

  In the superconducting biomagnetism measuring apparatus (100) according to the first aspect, the pulsation of the heart from the magnetocardiogram signal detected by the magnetocardiogram detection sensor (5b) without being affected by the position of the superconducting magnetic sensor (5a). If the magnetocardiographic data is collected by the superconducting magnetic sensor (5a) using this as a trigger, the time phases of the magnetocardiographic data with respect to the heart beat can be obtained even if they are collected at different times. . Therefore, an isomagnetic field diagram of the magnetocardiogram can be created based on these. And since it is not necessary to provide an electrocardiograph, the measurement of the weak magnetocardiogram will not be hindered by the electrocardiograph electrodes and wires becoming noise sources.

In a second aspect, the present invention provides at least one superconducting magnetic sensor (5a), superconducting magnetic sensor moving means (6) for moving the superconducting magnetic sensor (5a) relative to a living body, The first data collection means (20) for moving the superconducting magnetic sensor (5a) and collecting magnetocardiographic data at two or more measurement positions, and the movement of the superconducting magnetic sensor (5a) is substantially unaffected. In order to collect magnetocardiographic data by the magnetocardiogram detection sensor (5b) in parallel with the collection of magnetocardiographic data by the magnetocardiogram detection sensor (5b) for detecting the magnetocardiogram signal and the superconducting magnetic sensor (5a). Magnetocardial data for synchronizing the time phases of the magnetocardiographic data collected by the superconducting magnetic sensor (5a) based on the magnetocardiographic data collected by the second data collecting means (20) and the magnetocardiographic sensor (5b). Synchronization means (20) Providing a superconducting biomagnetic measurement apparatus (100), characterized in that.
In the superconducting biomagnetism measuring apparatus (100) according to the second aspect, the pulsation of the heart from the magnetocardiographic data collected by the magnetocardiogram detection sensor (5b) without being affected by the position of the superconducting magnetic sensor (5a). The phase of the magnetocardiographic data collected by the superconducting magnetic sensor (5a) in parallel with the collection of the magnetocardiographic data is also determined by the position of the superconducting magnetic sensor (5a). It can be detected without being affected by. This makes it possible to obtain magnetocardiographic data with the same time phase for heart beats from magnetocardiographic data collected at different times and at different times. I can do it. And since it is not necessary to provide an electrocardiograph, the measurement of the weak magnetocardiogram will not be hindered by the electrocardiograph electrodes and wires becoming noise sources.

  According to the superconducting biomagnetic measuring apparatus of the present invention, it is possible to align the time phases of heartbeat data of magnetocardiographic data collected at different positions at different times without providing an electrocardiograph.

  Hereinafter, the present invention will be described in more detail with reference to embodiments shown in the drawings. Note that the present invention is not limited thereby.

FIG. 1 is a configuration diagram illustrating a superconducting biomagnetism measuring apparatus 100 according to the first embodiment.
The superconducting biomagnetic measuring device 100 is surrounded by a magnetic / radio wave shield 1a and can accommodate a small animal A, a dewar room 2 installed on the small animal room 1, and a dewar room 2. The dewar 3, the sensor tube 4 having an outer diameter of 35 mm projecting from the floor of the dewar chamber 2 through the ceiling of the small animal chamber 1 to the center of the small animal chamber 1, and the lower end of the sensor tube 4 A superconducting magnetic sensor 5a installed, a magnetocardiographic sensor 5b installed in the sensor tube 4 but above the superconducting magnetic sensor 5a, and a superconducting magnetic sensor installed under the small animal room 1 5a and a base 15 accommodating an electronic circuit for driving the magnetocardiogram detection sensor 5b, and processing a signal from the electronic circuit to detect a magnetocardiogram signal from the magnetocardiogram detection sensor 5b or from the superconducting magnetic sensor 5a Collected It is provided an information processing apparatus 20.

The magnetic / radio wave shield 1a of the small animal room 1 is made of a laminate of two layers of permalloy and one layer of copper plate.
The dewar chamber 2 is also surrounded by a magnetic / radio wave shield made of a laminate of one layer of permalloy and one layer of aluminum plate.

  The sensor tube 4 is made of a fluororesin and has flexibility.

  On the floor in the small animal room 1, the Z stage 6 z that moves up and down by turning the knob 61, the X stage 6 x that moves back and forth by turning the knob 62, and the left and right by turning the knob 63. A small animal moving table 6 having a Y stage 6y is installed. The small animal moving table 6 is made of a nonmagnetic material such as plastic or brass.

The small animal room 1 has a left door 8L and a right door 8R that are double-split.
The right door 8R is provided with a notch 9 that is open on the side of the joint with the left door 8L. By passing the anesthetic liquid tube 10 through the cutout hole 9 and closing the left door 8L and the right door 8R to measure the magnetocardiogram and cerebral magnetic field of the small animal A, the anesthetic is injected from the anesthetic liquid injection device placed outside the small animal room 1. The liquid can be injected into the small animal A.

  When the temperature control bed 11 is used, by passing the hot water tube 12 through the cutout hole 9, the left door 8L and the right door 8R are closed and the magnetocardiogram and magnetoencephalogram of the small animal A are measured. Warm water can be supplied to and discharged from the temperature control bed 11 from the hot water circulation device placed in the room.

  Since the superconducting magnetic sensor 5a is one SQUID sensor and is in the very vicinity of the small animal A, it is possible to see the fine heart magnetic field distribution (high spatial resolution). Therefore, in the superconducting magnetic sensor 5a, different signals can be obtained depending on the relative position with respect to the heart, and can be used as data for creating a magnetocardiogram.

  The magnetocardiogram detection sensor 5b is also a single SQUID sensor, but since it is located slightly away from the small animal A, it is possible to blur the cardiac magnetic field distribution (low spatial resolution). Therefore, the magnetocardiogram detection sensor 5b can obtain a signal that hardly changes even if the relative position with respect to the heart is different, and can be used as a reference signal for aligning the time phases of the data obtained by the superconducting magnetic sensor 5a.

As shown in FIG. 2, measurement points K (1, 1) to K (4, 4) are determined in the vicinity of the heart of the small animal A in order to create an isomagnetic field diagram of the magnetocardiogram.
If the superconducting magnetic sensor 5a is moved relative to the positions P (1,1) to P (4,4) by moving the small animal moving table 6, the measurement points K (1,1) to K (4,4) ) Can be collected by the superconducting magnetic sensor 5a.

  As shown in FIG. 3, after the relative movement of the superconducting magnetic sensor 5a to the position P (1, 1), the information processing apparatus 20 detects the magnetocardiogram signal t (1, 1) from the magnetocardiogram detection sensor 5b. The heart beat phase is detected, and the collection of the magnetocardiographic data d (1, 1) by the superconducting magnetic sensor 5a is started using the predetermined phase as a trigger, and the collection is ended after a certain time. The obtained magnetocardiographic data d (1, 1) is magnetocardiographic data at the measurement point K (1, 1).

Next, after relatively moving the superconducting magnetic sensor 5a to the position P (1, 2), the information processing apparatus 20 detects the magnetocardiogram signal t (1, 2) from the magnetocardiogram detection sensor 5b, and beats the heart. The movement phase is detected, and the collection of the magnetocardiographic data d (1, 2) by the superconducting magnetic sensor 5a is started using the predetermined phase as a trigger, and the collection is terminated after a predetermined time. The obtained magnetocardiographic data d (1, 2) is magnetocardiographic data at the measurement point K (1, 2).
Since the position of the magnetocardiogram detection sensor 5b with respect to the small animal A also moves, there is a slight difference in waveform between the magnetocardiogram signal t (1,1) and the magnetocardiogram signal t (1,2). There is no difference in detecting the phase. In other words, the magnetocardiogram detection sensor 5b is installed at such a position.

  Next, after the superconducting magnetic sensor 5a is relatively moved to the position P (1,3), the information processing apparatus 20 detects the magnetocardiogram signal t (1,3) from the magnetocardiogram detection sensor 5b, and beats the heart. The movement phase is detected, and the collection of the magnetocardiographic data d (1,3) by the superconducting magnetic sensor 5a is started by using the predetermined phase as a trigger, and the collection is ended after a predetermined time. The obtained magnetocardiographic data d (1,3) is magnetocardiographic data at the measurement point K (1,3).

  Thereafter, the magnetocardiographic data d (1, 3) to d (4, 4) at the measurement points K (1, 3) to K (4, 4) are collected in the same manner.

  The magnetocardiographic data d (1, 1) to d (4, 4) at the measurement points K (1, 1) to K (4, 4) obtained as described above are collected at different times. Although it is data, the time phase for heart beats is aligned. Therefore, the information processing apparatus 20 creates an isomagnetic field diagram of the magnetocardiogram based on these.

  According to the first embodiment, since it is not necessary to provide an electrocardiograph, measurement of a weak magnetocardiogram is not hindered by an electrode or an electric wire of the electrocardiograph becoming a noise source.

  The second embodiment is a modification of the first embodiment so that the magnetocardiographic data having the same time phase with respect to the heart beat is extracted by post-processing.

  As shown in FIG. 4, after the relative movement of the superconducting magnetic sensor 5a to the position P (1, 1), the information processing apparatus 20 performs magnetocardiographic data T (1, 1, 1) from the magnetocardiogram detection sensor 5b at an arbitrary timing. ) And the collection of the magnetocardiographic data D (1, 1) by the superconducting magnetic sensor 5a are simultaneously started in parallel, and the collection is terminated after a certain time.

  Next, after the superconducting magnetic sensor 5a is relatively moved to the position P (1, 2), the information processing apparatus 20 collects the magnetocardiogram data T (1, 2) by the magnetocardiogram detection sensor 5b at an arbitrary timing. Collection of the magnetocardiographic data D (1, 2) by the superconducting magnetic sensor 5a is started in parallel at the same time, and the collection is finished after a certain time.

  Next, after relatively moving the superconducting magnetic sensor 5a to the position P (1,3), the information processing apparatus 20 collects the magnetocardiographic data T (1,3) by the magnetocardiogram detection sensor 5b at an arbitrary timing. Collection of the magnetocardiographic data D (1,3) by the superconducting magnetic sensor 5a is started in parallel at the same time, and the collection is finished after a certain time.

  Thereafter, the magnetocardiographic data T (1,3) to T (4,4) and D (1,3) to D (4,4) at positions P (1,3) to P (4,4) in the same manner. To collect.

  Thereafter, the information processing device 20 detects the phase of the heart beat from the magnetocardiogram data T (1, 1), and the magnetocardiogram data d (1, 1) from the predetermined phase to a certain time later is detected as the magnetocardiogram data. Cut out from D (1,1). Next, the phase of the heart beat is detected from the magnetocardiographic data T (1, 2), and the magnetocardiographic data d (1, 2) from a predetermined phase to a certain time later is converted to the magnetocardiographic data D (1, 2). ). Next, the phase of the heart beat is detected from the magnetocardiographic data T (1,3), and the magnetocardiographic data d (1,3) from a predetermined phase to a certain time later is obtained as the magnetocardiographic data D (1,3). ). Thereafter, the magnetocardiographic data d (1, 3) to d (4, 4) are similarly cut out.

  The magnetocardiogram data d (1, 1) to d (4, 4) cut out as described above are magnetocardiographic data collected at different times, but the time phases with respect to the heart beat are aligned. Therefore, the information processing apparatus 20 creates an isomagnetic field diagram of the magnetocardiogram based on these.

  According to the second embodiment, since it is not necessary to provide an electrocardiograph, measurement of weak magnetocardiograms is not hindered by the electrodes and electric wires of the electrocardiograph becoming a noise source.

  As shown in FIG. 5, four SQUID sensors 5a-1 to 5a-4 are formed as a superconducting magnetic sensor 5a on a single semiconductor substrate 7 in a 2 × 2 array, and these SQUID sensors 5a-1 to 5a-1 are formed. A loop coil is formed as the magnetocardiogram detection sensor 5b so as to surround 5a-4. A technique for integrating a plurality of SQUID sensors on one semiconductor substrate is disclosed in Japanese Patent Application Laid-Open No. 2006-349496.

As shown in FIG. 6, measurement points K (1, 1) to K (4, 4) are determined in the vicinity of the heart of the small animal A in order to create an isomagnetic field diagram of the magnetocardiogram.
If the superconducting magnetic sensor 5a is moved relative to the positions P (1,1) to P (2,2) by moving the small animal moving table 6, the measurement points K (1,1) to K (4,4) ) Can be collected by the superconducting magnetic sensor 5a.

  As shown in FIG. 7, after the superconducting magnetic sensor 5a is relatively moved to the position P (1, 1), the information processing apparatus 20 detects the magnetocardiogram signal t (1, 1) from the magnetocardiogram detection sensor 5b. , Detecting the phase of the heart beat, and using the predetermined phase as a trigger, the magnetocardiographic data d (1, 1), d (1, 2), d (2, 1), d ( Start collection in (2) and (2), and end collection after a certain period of time. The obtained magnetocardiographic data d (1, 1), d (1, 2), d (2, 1), d (2, 2) are measured points K (1, 1), K (1, 2). , K (2, 1), K (2, 2).

  Next, after relatively moving the superconducting magnetic sensor 5a to the position P (1, 2), the information processing apparatus 20 detects the magnetocardiogram signal t (1, 2) from the magnetocardiogram detection sensor 5b, and beats the heart. The motion phase is detected, and the magnetocardiographic data d (1, 3), d (1, 4), d (2, 3), d (2, 4) from the superconducting magnetic sensor 5a is triggered by a predetermined phase as a trigger. The collection is started, and the collection is terminated after a certain time. The obtained magnetocardiographic data d (1,3), d (1,4), d (2,3), d (2,4) are measured points K (1,3), K (1,4). , K (2,3), K (2,4).

  Next, after the superconducting magnetic sensor 5a is relatively moved to the position P (2, 1), the information processing apparatus 20 detects the magnetocardiogram signal t (2, 1) from the magnetocardiogram detection sensor 5b, and the heart beat. The motion phase is detected, and the magnetocardiographic data d (3, 1), d (3, 2), d (4, 1), d (4, 2) from the superconducting magnetic sensor 5a is triggered by a predetermined phase as a trigger. The collection is started, and the collection is terminated after a certain time. The obtained magnetocardiographic data d (3, 1), d (3, 2), d (4, 1), d (4, 2) are measured points K (3, 1), K (3, 2). , K (4, 1), K (4, 2).

  Finally, after the superconducting magnetic sensor 5a is relatively moved to the position P (2, 2), the information processing device 20 detects the magnetocardiogram signal t (2, 2) from the magnetocardiogram detection sensor 5b, and beats the heart. The motion phase is detected, and the magnetocardiographic data d (3, 3), d (3, 4), d (4, 3), d (4, 4) from the superconducting magnetic sensor 5a is triggered by the predetermined phase as a trigger. The collection is started, and the collection is terminated after a certain time. The obtained magnetocardiographic data d (3, 3), d (3, 4), d (4, 3), d (4, 4) are measured points K (3, 3), K (3, 4). , K (4,3), K (4,4).

  The magnetocardiographic data d (1, 1) to d (4, 4) at the measurement points K (1, 1) to K (4, 4) obtained as described above are collected at different times. Although it is data, the time phase for heart beats is aligned. Therefore, the information processing apparatus 20 creates an isomagnetic field diagram of the magnetocardiogram based on these.

  According to the third embodiment, since there is no need to provide an electrocardiograph, measurement of a weak magnetocardiogram is not hindered by an electrocardiograph electrode or electric wire as a noise source.

  The fourth embodiment is a modification of the third embodiment so that the magnetocardiographic data having the same time phase with respect to the heart beat is extracted by post-processing.

  As shown in FIG. 8, after the relative movement of the superconducting magnetic sensor 5a to the position P (1, 1), the information processing apparatus 20 detects the magnetocardiographic data T (1, 1, 1) from the magnetocardiogram detection sensor 5b at an arbitrary timing. ) And collection of magnetocardiographic data D (1, 1), D (1, 2), D (2, 1), D (2, 2) by the superconducting magnetic sensor 5a are started simultaneously in parallel. Collection ends after a certain time.

  Next, after the superconducting magnetic sensor 5a is relatively moved to the position P (1, 2), the information processing apparatus 20 collects the magnetocardiogram data T (1, 2) by the magnetocardiogram detection sensor 5b at an arbitrary timing. Collection of magnetocardiographic data D (1, 3), D (1, 4), D (2, 3), D (2, 4) by the superconducting magnetic sensor 5a starts simultaneously in parallel and is collected after a certain time. Exit.

  Next, after relatively moving the superconducting magnetic sensor 5a to the position P (2,1), the information processing apparatus 20 collects the magnetocardiographic data T (2,1) by the magnetocardiogram detection sensor 5b at an arbitrary timing. Collection of magnetocardiographic data D (3, 1), D (3, 2), D (4, 1), D (4, 2) by the superconducting magnetic sensor 5a is started in parallel at the same time, and after a certain time Exit.

  Finally, after the superconducting magnetic sensor 5a is relatively moved to the position P (2, 2), the information processing apparatus 20 collects the magnetocardiographic data T (2, 2) by the magnetocardiogram detection sensor 5b at an arbitrary timing. Collection of magnetocardiographic data D (3, 3), D (3, 4), D (4, 3), D (4, 4) by the superconducting magnetic sensor 5a starts simultaneously in parallel, and collects after a certain time Exit.

  Thereafter, the information processing device 20 detects the phase of the heart beat from the magnetocardiographic data T (1, 1), and the magnetocardiographic data d (1, 1), d (1) from a predetermined phase to a certain time later. , 2), d (2, 1), d (2, 2) are cut out from the magnetocardiographic data D (1, 1), D (1, 2), D (2, 1), D (2, 2) . Next, the phase of the heart beat is detected from the magnetocardiographic data T (1, 2), and the magnetocardiographic data d (1, 3), d (1, 4), d from a predetermined phase to a certain time later. (2, 3), d (2, 4) are cut out from the magnetocardiographic data D (1, 3), D (1, 4), D (2, 3), D (2, 4). Next, the phase of the heart beat is detected from the magnetocardiographic data T (2, 1), and the magnetocardiographic data d (3, 1), d (3, 2), d from a predetermined phase to a certain time later. (4,1) and d (4,2) are cut out from the magnetocardiographic data D (3,1), D (3,2), D (4,1) and D (4,2). Finally, the phase of the heart beat is detected from the magnetocardiogram data T (2, 2), and the magnetocardiogram data d (3, 3), d (3, 4), d from a predetermined phase to a certain time later. (4,3) and d (4,4) are cut out from the magnetocardiographic data D (3,3), D (3,4), D (4,3) and D (4,4).

  The magnetocardiogram data d (1, 1) to d (4, 4) cut out as described above are magnetocardiographic data collected at different times, but the time phases with respect to the heart beat are aligned. Therefore, the information processing apparatus 20 creates an isomagnetic field diagram of the magnetocardiogram based on these.

  According to the fourth embodiment, since there is no need to provide an electrocardiograph, measurement of a weak magnetocardiogram is not hindered by an electrocardiograph electrode or electric wire serving as a noise source.

  In the fifth embodiment, the moving pitch of the superconducting magnetic sensor 5a is modified to ¼ that of the third embodiment in order to increase the spatial resolution to twice that of the third embodiment.

  In order to create an isomagnetic field diagram of the magnetocardiogram, measurement points K (1, 1) to K (4, 4) are determined in the vicinity of the heart of the small animal A. However, the pitch of the measurement points K (1, 1) to K (4, 4) is 1/2 of that of the third embodiment.

  As shown in FIG. 9, after the superconducting magnetic sensor 5a is relatively moved to the position P (1, 1), the information processing apparatus 20 receives a magnetocardiogram signal t () from the magnetocardiogram detection sensor 5b as shown in FIG. 1, 1) is detected, the phase of the heartbeat is detected, and the magnetocardiographic data d (1, 1), d (1, 3), d () by the superconducting magnetic sensor 5a is triggered using the predetermined phase as a trigger. The collection of 3, 1) and d (3, 3) is started, and the collection is terminated after a predetermined time. The obtained magnetocardiographic data d (1, 1), d (1, 3), d (3, 1), d (3, 3) are measured points K (1, 1), K (1, 3). , K (3, 1), K (3, 3).

  Next, as shown in FIG. 10, after relatively moving the superconducting magnetic sensor 5a to the position P (1, 2), the information processing apparatus 20 starts from the magnetocardiogram detection sensor 5b as shown in FIG. The signal t (1, 2) is detected, the phase of the heart beat is detected, and the magnetocardiographic data d (1, 2), d (1, 4) from the superconducting magnetic sensor 5a is triggered using the predetermined phase as a trigger. , D (3, 2) and d (3, 4) are started, and the collection is ended after a predetermined time. The obtained magnetocardiographic data d (1, 2), d (1, 4), d (3, 2), d (3, 4) are measured points K (1, 2), K (1, 4). , K (3, 2), K (3, 4).

  Next, as shown in FIG. 11, after the superconducting magnetic sensor 5a is relatively moved to the position P (2, 1), the information processing apparatus 20 starts from the magnetocardiogram detection sensor 5b as shown in FIG. The signal t (2,1) is detected, the phase of the heart beat is detected, and the magnetocardiographic data d (2,1), d (2,3) from the superconducting magnetic sensor 5a is triggered by a predetermined phase as a trigger. , D (4, 1), d (4, 3) are started, and the collection is ended after a predetermined time. The obtained magnetocardiographic data d (2, 1), d (2, 3), d (4, 1), d (4, 3) are measured points K (2, 1), K (2, 3). , K (4, 1), K (4, 3).

  Next, as shown in FIG. 12, after the superconducting magnetic sensor 5a is relatively moved to the position P (2, 2), the information processing apparatus 20 receives the magnetocardiogram signal t (2, 2) from the magnetocardiogram detection sensor 5b. , The phase of the heart beat is detected, and the magnetocardiographic data d (2, 2), d (2, 4), d (4, 2) from the superconducting magnetic sensor 5a is triggered using the predetermined phase as a trigger. , D (4, 4) starts and ends after a certain time. The obtained magnetocardiographic data d (2, 2), d (2, 4), d (4, 2), d (4, 4) are measured points K (2, 2), K (2, 4). , K (4,2), K (4,4).

  The magnetocardiographic data d (1, 1) to d (4, 4) at the measurement points K (1, 1) to K (4, 4) obtained as described above are collected at different times. Although it is data, the time phase for heart beats is aligned. Therefore, the information processing apparatus 20 creates an isomagnetic field diagram of the magnetocardiogram based on these.

  According to the fifth embodiment, since it is not necessary to provide an electrocardiograph, the measurement of the weak magnetocardiogram is not hindered by the electrocardiograph electrodes and wires being noise sources.

  The sixth embodiment is a modification of the fifth embodiment so that the magnetocardiographic data having the same time phase with respect to the heart beat is extracted by post-processing.

  As shown in FIG. 14, after the superconducting magnetic sensor 5a is relatively moved to the position P (1, 1), the information processing apparatus 20 performs magnetocardiographic data T (1, 1, 1) from the magnetocardiogram detection sensor 5b at an arbitrary timing. ) And the collection of magnetocardiographic data D (1, 1), D (1, 3), D (3, 1), D (3, 3) by the superconducting magnetic sensor 5a, Collection ends after a certain time.

  Next, after the superconducting magnetic sensor 5a is relatively moved to the position P (1, 2), the information processing apparatus 20 collects the magnetocardiogram data T (1, 2) by the magnetocardiogram detection sensor 5b at an arbitrary timing. Collection of magnetocardiographic data D (1, 2), D (1, 4), D (3, 2), D (3, 4) by the superconducting magnetic sensor 5a is started in parallel at the same time, and is collected after a certain time. Exit.

  Next, after relatively moving the superconducting magnetic sensor 5a to the position P (2,1), the information processing apparatus 20 collects the magnetocardiographic data T (2,1) by the magnetocardiogram detection sensor 5b at an arbitrary timing. Collection of magnetocardiographic data D (2, 1), D (2, 3), D (4, 1), D (4, 3) by the superconducting magnetic sensor 5a is started in parallel at the same time, and after a certain time Exit.

  Next, after the superconducting magnetic sensor 5a is relatively moved to the position P (2, 2), the information processing apparatus 20 collects the magnetocardiogram data T (2, 2) by the magnetocardiogram detection sensor 5b at an arbitrary timing. Collection of magnetocardiographic data D (2, 2), D (2, 4), D (4, 2), D (4, 4) by the superconducting magnetic sensor 5a starts simultaneously in parallel, and is collected after a certain time. Exit.

  Thereafter, the information processing device 20 detects the phase of the heart beat from the magnetocardiographic data T (1, 1), and the magnetocardiographic data d (1, 1), d (1) from a predetermined phase to a certain time later. , 3), d (3, 1), d (3, 3) are extracted from the magnetocardiographic data D (1, 1), D (1, 3), D (3, 1), D (3, 3) . Next, the phase of the heart beat is detected from the magnetocardiographic data T (1, 2), and the magnetocardiographic data d (1, 2), d (1, 4), d from a predetermined phase to a certain time later. (3, 2), d (3, 4) are cut out from the magnetocardiographic data D (1, 2), D (1, 4), D (3, 2), D (3, 4). Next, the phase of the heart beat is detected from the magnetocardiographic data T (2, 1), and the magnetocardiographic data d (2, 2), d (2, 3), d from a predetermined phase to a certain time later. (4,1) and d (4,3) are cut out from the magnetocardiographic data D (2,2), D (2,3), D (4,1) and D (4,3). Next, the phase of the heart beat is detected from the magnetocardiographic data T (2, 2), and the magnetocardiographic data d (2, 2), d (2, 4), d from a predetermined phase to a certain time later. (4,2) and d (4,4) are cut out from the magnetocardiographic data D (2,2), D (2,4), D (4,2) and D (4,4).

  The magnetocardiogram data d (1, 1) to d (4, 4) cut out as described above are magnetocardiographic data collected at different times, but the time phases with respect to the heart beat are aligned. Therefore, the information processing apparatus 20 creates an isomagnetic field diagram of the magnetocardiogram based on these.

  According to the sixth embodiment, since there is no need to provide an electrocardiograph, measurement of a weak magnetocardiogram is not hindered by an electrocardiograph electrode or electric wire as a noise source.

  For example, it can be used to measure a magnetic field emitted from a small animal such as a mouse.

1 is a front view illustrating a biomagnetism measuring apparatus for small animals according to Example 1. FIG. It is a conceptual diagram which shows the position of the measurement point which concerns on Example 1, and a superconducting magnetic sensor. It is a conceptual diagram which shows the time relationship of the magnetocardiogram signal and magnetocardiogram data which concern on Example 1. FIG. It is a conceptual diagram which shows the time relationship of the magnetocardiographic data which concerns on Example 2. FIG. FIG. 10 is a plan view showing a superconducting magnetic sensor and a magnetocardiographic sensor according to Example 3. It is a conceptual diagram which shows the position of the measuring point which concerns on Example 3, and a superconducting magnetic sensor. It is a conceptual diagram which shows the time relationship of the magnetocardiogram signal based on Example 3, and magnetocardiogram data. It is a conceptual diagram which shows the time relationship of the magnetocardiographic data which concerns on Example 4. FIG. It is a conceptual diagram which shows the 1st position of the superconducting magnetic sensor which concerns on Example 5. FIG. It is a conceptual diagram which shows the 2nd position of the superconducting magnetic sensor which concerns on Example 5. FIG. It is a conceptual diagram which shows the 3rd position of the superconducting magnetic sensor which concerns on Example 5. FIG. It is a conceptual diagram which shows the 4th position of the superconducting magnetic sensor which concerns on Example 5. FIG. It is a conceptual diagram which shows the time relationship of the magnetocardiogram signal which concerns on Example 5, and magnetocardiogram data. It is a conceptual diagram which shows the time relationship of the magnetocardiographic data which concerns on Example 6. FIG.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Small animal room 1a Magnetic / radio wave shield 2 Dewar room 3 Dewar 4 Sensor tube 5a Superconducting magnetic sensor 5b Magnetomagnetic sensor 6 Small animal moving table 7 Sensor moving mechanism 8L, 8R Door 9 Notch 10 Anesthetic liquid tube 11 Temperature control bed 12 Hot water tube 100 Biomagnetism measuring device for small animals A Small animals

Claims (2)

  One or more superconducting magnetic sensors (5a), superconducting magnetic sensor moving means (6, 7) for moving the superconducting magnetic sensors (5a), and two or more superconducting magnetic sensors (5a) for moving A data collection means (20) for collecting magnetocardiogram data at a measurement position; a magnetocardiogram detection sensor (5b) for detecting a magnetocardiogram signal without being substantially affected by movement of the superconducting magnetic sensor (5a); A biomagnetism measuring device (100) comprising trigger means (20) for controlling collection of the magnetocardiographic data using the magnetocardiogram signal as a trigger.   One or more superconducting magnetic sensors (5a), superconducting magnetic sensor moving means (6) for moving the superconducting magnetic sensor (5a) relative to the living body, and moving the superconducting magnetic sensor (5a) First data collection means (20) for collecting magnetocardiogram data at two or more measurement positions, and a magnetocardiogram detection sensor for detecting a magnetocardiogram signal without being substantially affected by movement of the superconducting magnetic sensor (5a) (5b) and second data collection means (20) for collecting magnetocardiographic data by the magnetocardiogram detection sensor (5b) in parallel with collection of magnetocardiographic data by the superconducting magnetic sensor (5a), A magnetocardiographic data synchronization means (20) for synchronizing the time phases of magnetocardiographic data collected by the superconducting magnetic sensor (5a) based on the magnetocardiographic data collected by the magnetocardiogram detection sensor (5b); Superconducting life characterized by Magnetometric apparatus (100).

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