JP5143373B2 - Disinfectant / deodorant - Google Patents

Description

  The present invention relates to a disinfectant / deodorant comprising a silver-hydroxyapatite suspension produced by dispersing a silver colloid solution micronized to a set particle size or less in a hydroxyapatite solution micronized to a set particle size or less. In particular, the present invention relates to a sterilizing / deodorizing agent that can easily and effectively sterilize fungi in pet animals and remove odorous components, and sterilize infectious fungi and remove odorous components at various usage sites. .

  In recent years, pet animals such as dogs and cats have been bred indoors. Because pet animals are kept in indoor pet cases and perform excretion in indoor excrement cases, they are attached to pet animal bodies, pet cases, excrement cases, excrement etc. It is necessary to sterilize fungi and remove odor components.

  Further, when sterilizing fungi and removing odor components, it is necessary to sterilize and remove odor components such as on-site or clothes and masks to be worn.

As a conventional sterilizing / deodorizing agent for pet animals, there is one using a wood vinegar liquid powder obtained by converting a wood vinegar liquid into a dry powder.
JP-A-2-14670

Further, conventional pet animal sterilizing / deodorizing agents include those containing a deodorizing component such as tea extract, a sterilizing agent such as chloride, and a porous powder such as silica.
JP 2004-242516 A

In addition, some sterilizing / deodorizing agents such as on-site or clothing use iron complex compound solutions containing iron ions and organic peroxides, and contact bacteria-contaminated articles with iron complex compound solutions. Some of them are then brought into contact with an organic peroxide.
JP-A-5-305126

However, since it is difficult to sterilize a wide variety of fungi with conventional sterilizing / deodorizing agents, it is necessary to use multiple types of drugs. There was a risk of affecting the usage environment. As described above, conventional sterilizing / deodorizing agents for pet animals include organic ones and metal ones. In order to sterilize a wide variety of fungi, organic ones based on organic chemical reactions are used. Rather than metal-based disinfecting / deodorizing agents based on physical reactions, it seems more advantageous. In the metal system, one using copper, tin, zinc, silver or the like is known. Of these, silver is safe and effective. However, since silver is expensive, it is necessary to use silver finely dispersed. It was difficult to divide silver into nano-sized particles and stably disperse them.
It is also necessary to ensure efficient contact between the nanosized silver particles and the bacteria under low concentration conditions. For this purpose, fungi and silver are efficiently supplemented, and those that are safe for pet animals and humans are required, but as a result of the inventors' extensive research, for this purpose, calcium phosphate related to bone, We have discovered that this polymer, hydroxyapatite, is good. Hydroxyapatite has excellent adhesion to proteins, amino acids and the like, and is particularly excellent as providing a place for ensuring efficient contact between nanosized silver particles and bacteria.
In addition, since conventional sterilizing / deodorizing agents remove odor components with chemicals, the amount of chemicals must be increased in order to maintain the deodorizing function, and the chemical deodorizing function by use In order to recover the decline, it was necessary to replace it for a certain period.
Furthermore, conventionally, since sterilization and deodorization are performed separately, there is a problem that takes time and effort.

  The present invention can be easily and effectively sterilized and removed of odorous components of pet animals by being taken into the body of the pet animal or attached to the outside of the animal body. An object of the present invention is to provide a sterilizing / deodorizing agent that can easily and effectively sterilize infectious fungi and remove odorous components.

In this invention, a silver colloid solution is produced by mixing silver finely divided to 10 nm or less into a liquid, and a hydroxyapatite solution is produced by mixing hydroxyapatite finely divided to 500 nm or less into the liquid. It consists of a silver-hydroxyapatite suspension produced by dispersing in the hydroxyapatite solution. In the silver-hydroxyapatite suspension, a silica-based solution in which silica-based fine particles having silanol groups are mixed is dispersed. It is characterized by that.

The sterilizing / deodorizing agent of the present invention sterilizes a wide variety of fungi produced by mixing and dispersing a silver colloid solution micronized below a set particle size and a hydroxyapatite solution micronized below a set particle size. At the same time, it consists of a silver-hydroxyapatite suspension capable of removing odor components.
In this case, when the silver colloid solution is mixed with the hydroxyapatite solution, the silver colloid solution is finely divided silver mixed in the liquid so that the predetermined concentration (for example, 2 to 5 ppm) at which the bactericidal / deodorizing effect is most effectively observed. Adjust the concentration. This silver colloid solution is mixed and dispersed in a microparticulated hydroxyapatite solution having a predetermined concentration (for example, 100 ppm) to produce a hydroxyapatite suspension.
The produced hydroxyapatite suspension retains silver finely divided by hydroxyl groups of hydroxyapatite, so that the silver finely divided by hydroxyapatite can be stably present in the suspension. Maintaining an environment where silver silver ions can easily come into contact with fungi and odor components, increasing the chances of contact, and effectively decomposing fungi and odor components with silver ions to provide a bactericidal and deodorant effect Can do.
As a result, the disinfectant / deodorant of the present invention is particularly effective in infecting pet animals due to the disinfecting effect of the silver-hydroxyapatite suspension by being taken into the body of the pet animal or attached to the outside of the body. The fungi can be inactivated and sterilized, and the deodorizing effect of the silver-hydroxyapatite suspension can be easily deodorized by removing odor components from pet animals.
In addition, this disinfectant / deodorant is not limited to pet animals, and can be used for sprays, wiping materials, clothes, masks, etc. to easily disinfect infectious fungi and remove odorous components present in the environment of use. Can be done effectively.

The sterilizing / deodorizing agent of the present invention uses the sterilizing effect / deodorizing effect of the silver-hydroxyapatite suspension to sterilize / deodorize pet animals, sterilize infecting fungi present in the use environment, and The removal is performed. In particular, since this silver-hydroxyapatite suspension is extremely safe, it is used as a pet animal sterilizer / deodorant for beverage mineral water, feed, spray, wiping agent, shampoo, etc. Is.
Embodiments of the present invention will be described below with reference to the drawings.

  1 to 9 show an embodiment of the present invention. In FIG. 1, 2 is a disinfectant / deodorant. The sterilizing / deodorizing agent 2 comprises a silver-hydroxyapatite suspension 8 produced by dispersing a silver colloid solution 4 in a hydroxyapatite solution 6.

  The silver colloid solution 4 is produced by using finely divided silver 10 as a dispersoid, using liquid 12 as a dispersion medium, and dispersing finely divided silver 10 in liquid 12 and adjusting it to a predetermined concentration. The silver 10 is finely divided into particles of a set particle size or less, for example, 10 nm (nanometer) or less, preferably 4 nm or less, by a technique such as electrolysis or mechanical dispersion using zirconium. When the silver colloid solution 4 is mixed with the hydroxyapatite solution 6, the silver colloid solution 4 has a predetermined concentration capable of sterilizing infecting fungi and removing odor components, for example, 0.5 to 100 ppm, preferably 1 to 10 ppm, and more preferably 2 to 5 ppm. Then, the concentration of finely divided silver 10 in the liquid 12 is adjusted.

  The finely divided silver 10 floats in the liquid 12 due to the electric charge present on each fine particle and is dispersed in the liquid 12. Silver 10 has sterilizing power and deodorizing power. The liquid 12 in which the finely divided silver 10 is dispersed is made of, for example, pure water in which negative ions that react with silver ions are reduced, and the reduction of silver ions is prevented.

  The hydroxyapatite solution 6 is produced by suspending a hydroxyapatite 14 finely divided to a set particle size or less as a dispersoid in a dispersion medium of a liquid 16 and adjusting it to a predetermined concentration. Hydroxyapatite 14 is a hexagonal system and a kind of calcium phosphate, has excellent ion exchange ability, specifically reacts with amino acids, proteins, organic acids and the like, and has good hydrophilicity (affinity with water).

  Hydroxyapatite 14 is formed to have a particle size larger than the particle size of silver 10 finely divided by an appropriate technique and not more than a set particle size. For example, the hydroxyapatite 14 is formed into fine particles having a particle size of 3 to 500 nm, preferably 15 to 150 nm, of the finely divided silver 10. The hydroxyapatite solution 6 adjusts the concentration of the microparticulated hydroxyapatite 14 in the liquid 16 so as to be, for example, 100 ppm when the silver colloid solution 4 is mixed.

  The hydroxyapatite 14 is composed of inorganic fine particles such as titanium, silicate, calcium and the like. The microparticulated hydroxyapatite 14 has a large specific surface area, is porous, and is excellent in adsorption ability. The liquid 16 in which the micronized hydroxyapatite 14 is mixed is made of pure water in which negative ions are reduced, for example.

  The silver colloid solution 4 in which finely divided silver 10 is dispersed in a liquid 12 and adjusted to a predetermined concentration is dispersed in a hydroxyapatite solution 6 in which fine particle hydroxyapatite 14 is suspended in a liquid 16 and adjusted to a predetermined concentration. Thus, the silver-hydroxyapatite suspension 8 in which the finely divided silver 10 has a predetermined concentration and the finely divided hydroxyapatite 14 has a predetermined concentration is produced.

  Since the produced hydroxyapatite suspension 8 retains the silver 10 finely divided by the hydroxyl groups of the hydroxyapatite 14, the silver 10 finely divided by the hydroxyapatite 14 can be stably present in the suspension. It is possible to maintain an environment where the silver ions of finely divided silver 10 are easy to come into contact with fungi and odor components, and increase the chance of contact. Deodorizing effect can be achieved.

  Further, the reducing agent 18 is mixed in the silver-hydroxyapatite suspension 8. The reducing agent 18 is to prevent the oxidation of the finely divided silver 10 by maintaining the environment in the silver-hydroxyapatite suspension 8 in a reduced state, and vitamin C (ascorbic acid), vitamin E, β-carotene, Any one of the citric acids is mixed into the silver-hydroxyapatite suspension 8. The concentration of the reducing agent is, for example, 1 to 10 mM (mmol) / L.

  Furthermore, the silver-hydroxyapatite suspension 8 is mixed with an additive 20 as a nutritional source for pet animals as necessary. Additives 20 include amino acids, vitamins, and minerals. As the amino acid, for example, any one or more of 20 essential amino acids, taurine and the like are mixed so that the concentration becomes 1 to 10 mg / ml. As vitamins, for example, any one or more of vitamin A, vitamin B1, vitamin B2, vitamin D, vitamin K and the like are mixed so as to have a concentration of 0.1 to 1 mg / ml. As minerals, any one or more of calcium, magnesium, potassium, selenium, etc. are mixed so that a density | concentration may be 0.1-1 mg / ml.

  Next, the operation will be described.

  The sterilizing / deodorizing agent 2 is produced by dispersing and mixing a silver colloid solution 4 in which finely divided silver 10 is dispersed in a liquid 12 and a hydroxyapatite solution 16 in which finely divided hydroxyapatite 14 is dispersed. It consists of a silver-hydroxyapatite suspension 8. At this time, the silver-hydroxyapatite suspension 8 is produced by mixing the reducing agent 18 and the additive 20 as necessary.

  In the case of producing the sterilizing / deodorizing agent 2, as shown in FIG. 2, first, the silver 10 is micronized to a set particle size (for example, 4 nm) or less by a technique such as electrolysis (S1), and the micronized. Silver 10 is mixed and dispersed in the liquid 12 (S2) to produce a silver colloid solution 4 (S3). In this case, the silver colloid solution 4 is finely divided silver so as to have a predetermined concentration (for example, 2 to 5 ppm) that sterilizes pet animal fungi and removes odorous components in a state dispersed in the hydroxyapatite solution 16. 10 density is adjusted. In addition, the silver colloid solution 4 prevents the reduction of silver ions by dispersing finely divided silver 10 in a liquid 12 having a small amount of negative ions.

  Next, the hydroxyapatite 14 is micronized to a set particle size (for example, 15 nm) or less by an appropriate technique (S4), the micronized hydroxyapatite 14 is suspended in the liquid 16 (S5), and the hydroxyapatite solution 6 is obtained. Generate (S6). In the hydroxyapatite solution 6, the concentration of the microparticulated hydroxyapatite 14 is adjusted so as to be a predetermined concentration (for example, 100 ppm) when the silver colloid solution 4 is mixed. Further, the hydroxyapatite solution 6 prevents the decrease of silver ions in the dispersed silver colloid solution 4 by reducing the negative ions of the liquid 16 in which the microparticulated hydroxyapatite 14 is suspended.

  The prepared silver colloid solution 4 is dispersed and mixed in the prepared hydroxyapatite solution 6 (S7) to produce a silver-hydroxyapatite suspension 8 (S8). In the produced silver-hydroxyapatite suspension 8, finely divided silver 10 is dispersed at a predetermined concentration (for example, 2 to 5 ppm), and finely divided hydroxyapatite 14 is dispersed at a predetermined concentration (for example, 100 ppm). ing.

  The silver-hydroxyapatite suspension 8 retains the silver 10 finely divided by the hydroxyl groups of the hydroxyapatite 14, so that the silver 10 finely divided by the hydroxyapatite 14 can be stably present in the suspension. It is possible to maintain an environment where the silver ions of finely divided silver 10 are easy to come into contact with fungi and odor components, and increase the chance of contact. Deodorizing effect can be achieved.

  Further, the silver-hydroxyapatite suspension 8 is mixed with a reducing agent 18 for preventing oxidation of the finely divided silver 10 and / or an additive 20 as a nutrient source as required (S9). Deodorant 2 is obtained (S10).

  The pet animal bactericidal / deodorant 2 comprising the silver-hydroxyapatite suspension 8 obtained in this way exhibits a bactericidal effect as shown in the following tests on bactericidal action.

1. Test material 1) Test substance Silver-hydroxyapatite suspension 8 in which the final concentration of finely divided silver 10 was adjusted to 2.5 ppm and the final concentration of finely divided hydroxyapatite 14 was adjusted to 100 ppm.
2) Virus used (1) Human influenza virus A / Aichi / 2/68 (H3N2)
(2) Canine parvovirus Cp49 strain 3) Reaction conditions After mixing the silver-hydroxyapatite suspension 8 and the virus solution, they were reacted by shaking at 37 ° C. for 30 minutes, and then centrifuged to use the supernatant as a sample for residual virus. Number was measured.
The human influenza virus of (1) was measured using MDCK cells.
The canine parvovirus (2) was measured using CRFK cells.

2. Test Results In FIGS. 3 to 5, when there was no silver-hydroxyapatite suspension 8 (−), 23,800 human influenza viruses and 148,000 dog parvoviruses remained.
On the other hand, when the silver-hydroxyapatite suspension 8 was present (+), 100 or less of human influenza virus remained and 38 or less of canine parvovirus remained.
Thus, the bactericidal / deodorant 2 comprising the silver-hydroxyapatite suspension 8 is almost completely inactivated / removed against human influenza virus and canine parvovirus (99.9% or more). The effect was shown.

  In addition, the sterilizing / deodorizing agent 2 made of the silver-hydroxyapatite suspension 8 has a deodorizing effect as shown in the results of the gas adsorption test and the stationary test in FIG.

  In this gas adsorption test / stationary test, ammonia, tritylamine, acetic acid, acetaldehyde, formaldehyde, hydrogen sulfide are used as test gases, and the sterilization / extinguishment made of the silver-hydroxyapatite suspension 8 is placed in a 1 liter Tedlar bag. A sample 1 g of odorant 2 was put, filled with a test gas, and the concentration was measured with a gas detector tube every predetermined time.

  In this test, the first test substance and the second test substance were used as other test substances for comparison with the test of the bactericidal / deodorant 2 comprising the silver-hydroxyapatite suspension 8. And were tested. In FIG. 6, A is a first test substance, B is a second test substance, C is a sterilizing / deodorizing agent 2 made of a silver-hydroxyapatite suspension 8 adjusted to a silver concentration of 20 ppm, and D is a first test substance. 2 test substance B + bactericidal / deodorant 2 (silver concentration 20 ppm).

  According to the gas adsorption test and the stationary test, the sterilizing / deodorizing agent 2 has a result of exhibiting the deodorizing effect as shown in FIG.

  Thus, the sterilizing / deodorizing agent 2 comprising the silver-hydroxyapatite suspension 8 in which the concentration of finely divided silver 10 in the liquid is adjusted to a predetermined concentration has a sterilizing / deodorizing effect and is a beverage. Drink pet animals as mineral water, mix with feed, feed pet animals, spray pet animals and pet cases as a spray, wipe pet animals and pet cases as a cleaning material, mix with shampoo and pet It can be used to wash animals.

  The sterilizing / deodorizing agent 2 taken into the pet animal body as mineral water for drink and feed removes odor components by sterilizing fungi without adversely affecting the health of the animal in the animal body. In addition, the fungus of excreted excreta can be sterilized to remove odor components. In addition, when it is taken into the body of a pet animal, it is desirable to adjust the concentration of silver 10 in the liquid of the sterilizing / deodorizing agent 2 so that the blood concentration of silver 10 in the body is at least 5 ppm. .

  Further, the disinfectant / deodorant 2 attached to the outside of the pet animal as a spray, a wiping material, or a shampoo can disinfect fungi and remove odor components without adversely affecting the pet animal's skin. I can do it.

  As described above, the sterilizing / deodorizing agent 2 is obtained by mixing the silver colloid solution 4 in which the silver 10 finely divided to a set particle size (preferably 4 nm) or less is mixed and dispersed in the liquid 12 into the hydroxyapatite solution. Dispersed and finely divided silver 10 is adjusted to a predetermined concentration (desirably 2 to 5 ppm) to sterilize pet animal fungi and remove odor components, and finely divided hydroxyapatite 14 has a predetermined concentration (for example, 100 ppm). It consists of an adjusted silver-hydroxyapatite suspension 8.

  The produced silver-hydroxyapatite suspension 8 retains the silver 10 finely divided by the hydroxyl groups of the hydroxyapatite 14, so that the silver 10 finely divided by the hydroxyapatite 14 is stably present in the suspension. It is possible to maintain an environment where the silver ions of finely divided silver 10 are easy to come into contact with fungi and odor components, increasing the chance of contact, and the fungi and odor components are efficiently decomposed and sterilized by silver ions. An effect and a deodorizing effect can be produced.

  Thus, the sterilizing / deodorizing agent 2 can be taken into the body of the pet animal or adhered to the outside of the pet animal to inactivate and sterilize the fungus of the pet animal by the sterilizing effect of the finely divided silver 10. In addition, the odor component of the pet animal can be decomposed and deodorized by the deodorizing effect of the finely divided silver 10, and the fungus of the pet animal can be sterilized and the odor component can be easily and effectively removed.

  The sterilizing / deodorizing agent 2 is used in the silver-hydroxyapatite suspension 8 to reduce the particulate 10 by maintaining the environment in the liquid in a reduced state (for example, vitamin C or the like). ) 18 is mixed. Thereby, this sterilizing / deodorizing agent 2 can prevent the oxidation of finely divided silver 10 and maintain the sterilizing effect / deodorizing effect, and can effectively sterilize / deodorize pet animals. .

  Further, the sterilizing / deodorizing agent 2 is mixed with an additive (for example, amino acids, vitamins, mineralols, etc.) 20 as a nutrient for pet animals in the silver-hydroxyapatite suspension 8. Thereby, this disinfectant / deodorant 2 can sufficiently nourish the pet animal to enhance the physical strength, and can increase the low resistance against the fungus of the pet animal to prevent the disease.

  Further, the sterilizing / deodorizing agent 2 has a concentration of finely divided silver 10 in the silver-hydroxyapatite suspension 8 to a predetermined concentration for sterilizing infectious fungi at various sites of use and removing odor components. By adjusting and using for sprays, wiping materials, clothes, masks, etc., as shown in the test for antibacterial action below, sterilization and odor components of infecting fungi not only for pet animals but also in the use environment Can be easily and effectively removed.

  The tests shown in FIGS. 7 to 9 are sterilization / deodorization in which the concentration of finely divided silver 10 in the liquid of the silver-hydroxyapatite suspension 8 is adjusted to a predetermined concentration for sterilizing infectious fungi and removing odor components. This is an antibacterial test using Agent 2. In this test, lab coat treated with silver-hydroxyapatite suspension 8 was used as a sample, and the bacterial count and bactericidal activity at 0 and 50 washes for each of Staphylococcus aureus, Neisseria pneumoniae and MRSA. Values and bacteriostatic activity values were measured.

  According to the tests shown in FIG. 7 to FIG. 9, this disinfectant / deodorant 2 was able to suppress the increase in the number of bacteria by using the silver-hydroxyapatite suspension 8. For this reason, this bactericidal / deodorant 2 can easily and effectively sterilize infecting fungi present in the use environment.

  The sterilizing / deodorizing agent 2 of this example is composed of a silver colloid solution 4 in which finely divided silver 10 is mixed and dispersed in a liquid 12, and a hydroxy in which finely divided hydroxyapatite 14 is mixed and dispersed in a liquid 14. A silver-hydroxyapatite suspension 8 was produced by mixing and dispersing in the apatite solution 6. The silver-hydroxyapatite suspension 8 obtained by dispersing the silver colloid solution 4 in the hydroxyapatite solution 6 has a silanol group. A silica-based solution in which silica-based fine particles are mixed in a liquid can also be dispersed.

  A silver-hydroxyapatite suspension 8 composed of a silver colloid solution 4, a hydroxyapatite solution 6 and a silica-based solution retains silver 10 finely divided by hydroxyl groups of hydroxyapatite 14 and is a hydrogen bond net of silanol groups. Since the silver 10 and the hydroxyapatite 14 are retained, the silver 10 finely divided by the hydroxyapatite 14 and the silica-based fine particles can be more stably present in the suspension, and the silver ions are in contact with fungi and odor components. It is possible to maintain an easy-to-operate environment and further increase contact opportunities, and it is possible to further effectively decompose fungi and odor components with silver ions to achieve a sterilizing effect and a deodorizing effect.

The sterilizing / deodorizing agent of the present invention is composed of a silver-hydroxyapatite suspension containing finely divided silver adjusted to a predetermined concentration for sterilizing infectious fungi in the environment of use and removing odorous components. Because it is highly safe, it can sterilize infectious fungi in pet animals and remove odor components from pet animals to deodorize them. Not only pet animals but also other livestock It goes without saying that it can be applied.
In addition to sterilizing / deodorizing agents for pet animals, it can be used for sprays, wiping materials, clothes, masks, etc., to easily and effectively sterilize infectious fungi and remove odorous components in the environment of use. Can be done automatically.

It is a block diagram of the silver-hydroxyapatite suspension production | generation of the disinfection and deodorizing agent for pet animals which shows an Example. It is a flowchart of silver-hydroxyapatite suspension production | generation. It is a figure explaining the virus remaining number by the presence or absence of silver-hydroxyapatite suspension. It is a figure explaining the influence of the silver-hydroxyapatite suspension which acts on a human influenza virus. It is a figure explaining the influence of silver-hydroxyapatite suspension on canine parvovirus. It is a figure explaining the result of the gas adsorption test and stationary test by a silver-hydroxyapatite suspension. It is a figure explaining the result of the antimicrobial test with respect to Staphylococcus aureus by silver-hydroxyapatite suspension. It is a figure explaining the result of the antibacterial property test with respect to Klebsiella pneumoniae by silver-hydroxyapatite suspension. It is a figure explaining the result of the antibacterial property test with respect to MRSA by silver-hydroxyapatite suspension.

Explanation of symbols

2 Bactericidal / deodorant 4 Silver colloid solution 6 Hydroxyapatite solution 8 Silver-hydroxyapatite suspension 10 Silver 12 Liquid mixed with silver 10 14 Hydroxyapatite 16 Liquid mixed with hydroxyapatite 14 18 Reducing agent 20 Additive

Claims (1)

A silver colloid solution is produced by mixing silver finely divided to 10 nm or less into a liquid, a hydroxyapatite solution is produced by mixing hydroxyapatite finely divided to 500 nm or less , and the silver colloid solution is used as the hydroxyapatite solution. It consists of a silver-hydroxyapatite suspension produced by dispersing it in, and the silver-hydroxyapatite suspension is dispersed in a silica-based solution in which silica-based fine particles having silanol groups are mixed. Bactericidal and deodorant.

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