JP5283740B2 - Trypsin inhibitor - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a new trypsin inhibitor containing a specific plant extract. <P>SOLUTION: There is provided the trypsin inhibitor containing gentian extract. Trypsin which is a kind of serine proteases included in proteases is present in excrement of animals including human and, accordingly, it is known that trypsin causes rash and dermatitis around anus and artificial anus and onset of diaper rash, etc. Accordingly, it is expected that the trypsin inhibitor can be used as a means for effectively preventing or ameliorating pancreatitis, thrombogenesis, dermatitis around excretion organs, diaper rash, etc. Concretely, trypsin inhibitor can be compounded as an active ingredient to external drugs and quasi-drugs such as ointment, lotion, cream and milky lotion, cleansing cosmetics, buttock wiping wet tissue, baby powder, sanitary sheet, nursing sheet, etc., and foods represented by health foods, etc. <P>COPYRIGHT: (C)2012,JPO&amp;INPIT

Description

  The present invention relates to a trypsin inhibitor containing a specific plant extract.

Trypsin, a kind of serine protease that is a proteolytic enzyme, causes acute or chronic pancreatic inflammation and thrombus formation (Patent Document 1). Furthermore, since this enzyme is also contained in the excrement of animals including humans, it is known that it may cause rashes, skin irritation, and diaper rashes in the area around the anus and colostomy. (Non-Patent Documents 1 and 2). Therefore, it is conceivable to use a trypsin inhibitor as one method for effectively preventing or ameliorating pancreatic inflammation, thrombus formation, skin inflammation, diaper rash, etc. in the region around the excretory organ.
Japanese Patent Laid-Open No. 5-85934 Meyer Hoffert Ulf et al., Trypsin induces epidermal proliferation and inflammation in murine skin, Experimental Dermatology, 13, 234-241 (2004) Toru Takahashi, Jun Sugiura, Inhibitory effect on enzymes involved in diaper rash of eucalyptus extract, Abstracts of the 122nd Annual Meeting of the Pharmaceutical Society of Japan, 111

  The problem to be solved is to provide a novel trypsin inhibitor.

  The inventors of the present invention include Ezokogi, Achillea millefolium, Shobu, Horse Chestnut, Kara Touki, Roman Chamomile, Uwaurushi, Arnica, Toadoka, Oolongcha, Daidai, Coffea, Hawthorn, Turmeric, Horsetail, Loquat, Gardenia, Carrot, Gentian, Ginkgo biloba, American witch hazel, American ivy, Bushweed, Dokudami, Hops, Hypericum perforatum, Green squirrel, Atlantic squirrel, Oyster millet, Purple squirrel, Blue mallow, Common mint Elderberry, Savonsou, Yukinoshita, Clara, Crested hinoki, Japanese dandelion, Periwinkle, Fuyubodaiju, Salamander, Lemongrass, Mosquito , Ginger, grape, button, yellowfin, Dutch jellie, spinach, cucumber, watermelon, Japanese radish, onion, potato, pumpkin, garlic, primrose, red snapper, valerian, chickweed, chickweed, pineapple, green walnut, bread An extract of a plant selected from white willow, European raspberry, pine pine, cypress, angelica, centifolia rose, lime, bubuia uelanedae, eupatium purpleum, and devil's claw has excellent trypsin inhibitory action As a result, the present inventors have completed the trypsin inhibitor useful for the prevention or improvement of pancreatic inflammation, thrombus formation, skin inflammation and diaper rash in the surrounding area of the excretory organ, and the present invention. .

  That is, the present invention relates to Ezokogi, Achillea millefolium, Shobu, Horse chestnut, Karatouki, Roman chamomile, Uwaurushi, Arnica, Dermatosus, Oolongcha, Daidai, Coffee tree, Hawthorn, Turmeric, Horsetail, Biwa, Flounder, Gardenia, Carrot, Ginkgo biloba, American witch hazel, American ivy, Bushweed, Dokudami, Hops, Hypericum perforatum, Green squirrel, Atlantic squirrel, Oyster millet, Purple squirrel, Blue mallow, Common mint Elderberry, Savonsou, Yukinoshita, Clara, Choujinoki, Fuukidanpopo, Hachidanso, Fuyubodaiju, Salamander, Lemongra , Oysters, ginger, grapes, buttons, yellowfin, Dutch jellies, spinach, cucumbers, watermelon, radish, onion, potato, pumpkin, garlic, primrose, quinolino, valerian, chickweed, chickweed, yellow primrose, gram Extraction of one or more kinds of plants selected from elegans, white willow, European raspberry, pine pine, cypress, angelica, centifolia rose, lime, beviaiae lanedae, eupatium purpleum, devil's claw The present invention provides a trypsin inhibitor containing a product.

  A trypsin inhibitor containing a specific plant extract according to the present invention has an excellent trypsin inhibitory action and is effective for pancreatic inflammation, thrombus formation, skin inflammation and diaper rash in the surrounding area of excretory organs, etc. It is a drug that can be prevented or improved.

  The sorghum extract used in the present invention is obtained by extracting the root bark of Acanthopanax senticosus (Rupr. Et Maxim.) Harms using a solvent. The root bark is preferably appropriately cut or crushed.

  The Achillea millefolium extract used in the present invention is obtained by extracting a whole plant of Achillea millefolium L. using a solvent. The whole plant is preferably cut or crushed appropriately.

  The ginger extract used in the present invention is obtained by extracting a rhizome of Acorus calamus L. var. Asiaticus Pers. Using a solvent. The rhizome is preferably cut or crushed appropriately.

  The horse chestnut extract used in the present invention is obtained by extracting a seed or bark, preferably a seed, of Aceulus hippocastanum L. using a solvent. It is preferable to use seeds or bark appropriately cut or crushed.

  The Kara Toki extract used in the present invention is obtained by extracting the roots (herbal medicine name: Toki) of Angelica sinensis (Oliv.) Diels using a solvent. The root is preferably cut or crushed appropriately.

  The Roman chamomile extract used in the present invention is obtained by extracting a flower of the genus Anthemis nobilis L. using a solvent. It is preferable to use flowers that have been appropriately cut or crushed.

  The walrus extract used in the present invention is obtained by extracting leaves of Arctostaphylos uva-ursi (L.) Sprengel using a solvent. It is preferable to use leaves that have been appropriately cut or crushed.

  The Arnica extract used in the present invention is obtained by extracting roots or flowers, preferably flowers, of Arnica montana L. using a solvent. The roots or flowers are preferably cut or crushed appropriately.

  The eucalyptus extract used in the present invention is obtained by extracting flowers of the genus Calendula officinalis L. using a solvent. It is preferable to use flowers that have been appropriately cut or crushed.

  The oolongcha extract used in the present invention is obtained by semi-fermenting leaves of Thea sinensis L. using a solvent. It is preferable to use leaves that have been appropriately cut or crushed.

  The daidai extract used in the present invention is the fruit skin (herb medicine name: spruce) or immature fruit (herb medicine name: pheasant) of Citrus aurantium L. var. Daidai Makino, preferably the fruit skin, It was obtained by using and extracting. The peel or immature fruit is preferably cut or crushed appropriately.

  The coffee tree extract used in the present invention is obtained by extracting the roasted or non-roasted seeds of Coffea arabica L. using a solvent. It is preferable to use seeds that have been appropriately cut or ground.

  The hawthorn extract used in the present invention is obtained by extracting a fruit of the family Rosaceae (Crataegus cuneate Sieb. Et Zucc.) Using a solvent. It is preferable to use fruits that have been appropriately cut or ground.

  The turmeric extract used in the present invention is obtained by extracting a rhizome of the genus Curcuma longa L. using a solvent. The rhizome is preferably cut or crushed appropriately.

  The horsetail extract used in the present invention is obtained by extracting a stem, leaf or whole plant of Equisetum arvense L. using a solvent. The stem, leaf or whole plant is preferably cut or crushed appropriately.

  The loquat extract used in the present invention is obtained by extracting leaves, seeds or fruits, preferably leaves, of a rosaceae loquat (Eriobotrya japonica (Thunb.) Lindl.) Using a solvent. . It is preferable to use leaves, seeds or fruits appropriately cut or crushed.

  The fennel extract used in the present invention is obtained by extracting a fruit of the genus Felonicaceae genus (Foeniculum vulgare Mill.) Using a solvent. It is preferable to use fruits that have been appropriately cut or ground.

  The gardenia extract used in the present invention is obtained by extracting the fruit (herbal medicine name: Sanshishi) of Gardenia jasminoides Ellis forma grandiflora (Lour.) Makino using a solvent. . It is preferable to use fruits that have been appropriately cut or ground.

  The carrot extract used in the present invention is obtained by extracting leaves or roots, preferably roots, of a carrot family carrot (Daucus carota L.) using a solvent. It is preferable to use leaf or root that has been appropriately cut or ground.

  The gentian extract used in the present invention is obtained by extracting the root or rhizome, preferably the root, of Gentiana lutea L. using a solvent. The root or rhizome is preferably appropriately cut or crushed.

  The Ginkgo biloba extract used in the present invention is obtained by extracting seeds or leaves, preferably leaves, of Ginkgo biloba L. using a solvent. It is preferable to use seeds or leaves appropriately cut or ground.

  The American witch hazel extract used in the present invention is obtained by extracting the leaves of the witch hazel genus American witch hazel (Hamamelis virginiana L.) using a solvent. It is preferable to use leaves that have been appropriately cut or crushed.

  The ivy extract used in the present invention is obtained by extracting a leaf or stem, preferably a leaf, of Hedera helix L. using a solvent. It is preferable to use leaf or stem that has been appropriately cut or crushed.

  The Bushroom extract used in the present invention is a leaf or flower, preferably a flower, of Hibiscus rosa-sinensis L., H. schizopetalus Hook. F. It was obtained by using and extracting. It is preferable to use leaves or flowers that have been appropriately cut or ground.

  The dokudami extract used in the present invention is obtained by extracting the above-ground part of flowering stage (herbal medicine name: juyaku) of Houttuynia cordata Thunb. Using a solvent. It is preferable to use an appropriately cut or crushed ground part.

  The hop extract used in the present invention is obtained by extracting a fruit head of a mulberry genus hop (Humulus lupulus L.) using a solvent. It is preferable to use fruit ears that have been appropriately cut or crushed.

  The Hypericum perforatum extract used in the present invention is obtained by extracting a flower, fruit or whole grass, preferably whole grass of Hypericum perforatum L. using a solvent. . It is preferable to use flowers, fruits or whole plants that have been appropriately cut or ground.

  The squirrel extract used in the present invention is a product obtained by extracting a root or rhizome, preferably a root, of a genus Iris florentina L., preferably using a solvent. The root or rhizome is preferably appropriately cut or crushed.

  The Apricot extract used in the present invention is obtained by extracting a fruit of the juniperus communis L. using a solvent. It is preferable to use fruits that have been appropriately cut or ground.

  The licorice extract used in the present invention is an extract of flowers, stems or leaves of Lamium album L. var. Barbatum (Sieb. Et Zucc.) Franch. Et Savat. Using a solvent. It was obtained. It is preferable to use flowers, stems or leaves that are appropriately cut or crushed.

  The murasaki extract used in the present invention is obtained by extracting the roots (Liquispermum erythrorhizon Sieb. Et Zucc.) Roots (herbal medicine name: Shikon) using a solvent. The root is preferably cut or crushed appropriately.

  The mallow extract used in the present invention is obtained by extracting leaves or flowers, preferably flowers, using a solvent in the mallow family mallow (Malva sylvestris L. var. Mauritiana Mill.) It is. It is preferable to use leaves or flowers that have been appropriately cut or ground.

  The extract of the wild mint used in the present invention is obtained by extracting a leaf or flower, preferably a leaf, of Melissa officinalis L. using a solvent. . It is preferable to use leaves or flowers that have been appropriately cut or ground.

  The extract of Merirotsou used in the present invention is obtained by extracting the whole plant of the leguminous genus Melilotus officinalis Lam. Using a solvent. The whole plant is preferably cut or crushed appropriately.

  The mint extract used in the present invention is obtained by extracting the whole plant of the Labiatae genus Peppermint (Peppermint) using a solvent. The whole plant is preferably cut or crushed appropriately.

  The mulberry extract used in the present invention is obtained by extracting a root bark or leaf of a mulberry family mulberry (Morus alba L.), preferably a root bark (herbal medicine name: Sohakuhi) using a solvent. It is. The root bark or leaves are preferably appropriately cut or ground.

  The peony extract used in the present invention is obtained by extracting the roots of the genus Buttonae peony (Paeonia lactiflora Pall.) Using a solvent. The root is preferably cut or crushed appropriately.

  The Diou extract used in the present invention is obtained by extracting the roots of Rehmannia glutinosa Libosch. Var. Purpurea Makino using a solvent. The root is preferably cut or crushed appropriately.

  The rosemary extract used in the present invention is obtained by extracting whole plant of Rosmarinus officinalis L. using a solvent. The whole plant is preferably cut or crushed appropriately.

  The extract of Salvia officinalis used in the present invention is obtained by extracting a flower, leaf or whole plant of Salvia officinalis L. using a solvent. is there. It is preferable to use flowers, leaves or whole plants that have been appropriately cut or crushed.

  The elderberry extract used in the present invention is obtained by extracting a leaf, stem or flower, preferably a flower, of Sambucus nigra L., using a solvent. It is preferable to use leaves, stems or flowers appropriately cut or crushed.

  The extract of Soybean used in the present invention is obtained by extracting leaves or rhizomes, preferably leaves, of a genus Saponalia officinalis L. using a solvent. It is preferable to use leaf or rhizome appropriately cut or crushed.

  The Yukinoshita extract used in the present invention is obtained by extracting a leaf or whole plant, preferably whole plant, of Saxifraga stolonifera Meerb. Using a solvent. It is preferable to use leaf or whole grass that has been appropriately cut or ground.

  The Clara extract used in the present invention is obtained by extracting the root of the Sophora flavescens Aiton (herbal medicine name: Kudin) using a solvent. The root is preferably cut or crushed appropriately.

  The Chounotoki extract used in the present invention is obtained by extracting cocoons of Syzygium aromaticum (L.) Merr. Et Perry using a solvent. It is preferable to use a material that has been appropriately cut or crushed.

  The dandelion extract used in the present invention is obtained by extracting a flower, bud or leaf, preferably a flower, of a asteraceae genus Tussilago farfara L. using a solvent. It is preferable to use flowers, buds or leaves that are appropriately cut or crushed.

  The extract of the ginger is used to extract the above-ground part of Thymus vulgaris L. (Thymus vulgaris L.) using a solvent. It is preferable to use an appropriately cut or crushed ground part.

  An extract obtained from the present invention is obtained by extracting a flower, inflorescence, leaf or bark, preferably a flower or leaf, using a solvent, from the genus Tilia cordata Mill. It is. Flowers, inflorescences, leaves or bark are preferably cut or crushed appropriately.

  The salamander extract used in the present invention is obtained by extracting a fruit or pericarp, preferably pericarp, of a Zanthoxylum piperitum (L.) DC. Using a solvent. is there. It is preferable to use fruit or pericarp that has been appropriately cut or crushed.

  The lemongrass extract used in the present invention is obtained by extracting leaves, stems or fruit ears, preferably leaves or stems, using a solvent with a grass grass (Cymbopogon citratus (DC.) Stapf). Is. It is preferable to use leaves, stems or fruit ears that have been appropriately cut or crushed.

  The oyster extract used in the present invention is obtained by extracting a leaf or persimmon (Diospyros kaki Thunb.) Leaves or persimmon (herbal medicine name: City), preferably persimmon, using a solvent. . It is preferable to use leaf or cocoon appropriately cut or crushed.

  The ginger extract used in the present invention is obtained by extracting a rhizome of Zingiber officinale (L.) Rosc. Using a solvent. The rhizome is preferably cut or crushed appropriately.

  The grape extract used in the present invention is obtained by extracting a fruit or leaf, preferably a leaf, of a grape vine (Vitis vinifera L.) using a solvent. It is preferable to use fruits or leaves that have been appropriately cut or ground.

  The button extract used in the present invention is obtained by extracting the root bark (name of crude drug: button pi) of the button family button genus button (Paeonia suffruticosa Andr.) Using a solvent. The root bark is preferably appropriately cut or crushed.

  The yellowfin extract used in the present invention is obtained by extracting a bark of the genus Phellodendron amurense Rupr. Using a solvent. The bark is preferably cut or crushed appropriately.

  The Dutch jellied extract used in the present invention is obtained by extracting leaves or seeds of petroselinum sativum Hoffman (Umbelliferae), preferably leaves, using a solvent. It is. It is preferable to use leaves or seeds that have been appropriately cut or ground.

  The spinach extract used in the present invention is obtained by extracting a leaf or whole plant, preferably a leaf, of the spinach genus spinach (Spinacia oleracea L.) using a solvent. It is preferable to use leaf or whole grass that has been appropriately cut or ground.

  The cucumber extract used in the present invention is obtained by extracting the fruit of Cucuis sativus L. using a solvent. It is preferable to use fruits that have been appropriately cut or ground.

  The watermelon extract used in the present invention is obtained by extracting a fruit, pericarp or seed, preferably a fruit of a watermelon melon (Citrullus vulgaris Schrad.) Using a solvent. It is preferable to use fruits, pericarps or seeds that have been appropriately cut or ground.

  The radish extract used in the present invention is obtained by extracting the roots, leaves or seeds of Raphanus sativus L. var. Hortensis Backer, preferably the roots, using a solvent. . Roots, leaves, or seeds are preferably appropriately cut or crushed.

  The onion extract used in the present invention is obtained by extracting bulbs, bulbous bark or root bark of Allium cepa L., preferably bulbous skin, with a solvent. The bulb, bulbous bark or root bark is preferably cut or crushed appropriately.

  The potato extract used in the present invention is obtained by extracting tubers of Solanum tuberosum L. using a solvent. It is preferable to use a tuber appropriately cut or crushed.

  The pumpkin extract used in the present invention is obtained by extracting cucumbers, seeds or fruits, preferably fruits, of Cucurbita moschata Duch. Using a solvent. It is preferable to use cocoons, seeds or fruits appropriately cut or crushed.

  The garlic extract used in the present invention is obtained by extracting bulbs of Allium sativum L. using a solvent. It is preferable to use a bulb that is appropriately cut or crushed.

  The extract of primrose primrose used in the present invention is obtained by extracting a flower, a leaf or a root, preferably a flower, of Primura vulgaris Huds. Using a solvent. The flowers, leaves or roots are preferably cut or crushed appropriately.

  The Aquinoline extract used in the present invention is obtained by extracting the whole plant of Solidago virga-aurea L. var. Asiatica Nakai using a solvent. The whole plant is preferably cut or crushed appropriately.

  The valerian extract used in the present invention is obtained by extracting a root or a rhizome, preferably a root of Valeriana officinalis L., using a solvent. The root or rhizome is preferably appropriately cut or crushed.

  The chickweed extract used in the present invention is obtained by extracting the whole plant of Stellaria media (L.) Villars using a solvent. The whole plant is preferably cut or crushed appropriately.

  The himefuuro extract used in the present invention is obtained by extracting the whole plant of the genus Geranium robertianum L. using a solvent. The whole plant is preferably cut or crushed appropriately.

  As for the evening primrose extract used in the present invention, the seed of Oenothera biennis L. (O. striata, O. laciniata, O. erythrosepala) is extracted using a solvent. It was obtained. It is preferable to use seeds that have been appropriately cut or ground.

  The walnut extract used in the present invention is obtained by extracting a leaf or seed, preferably a leaf, of a walnut genus (Juglans regia L.) using a solvent. It is preferable to use leaves or seeds that have been appropriately cut or ground.

  The pansy extract used in the present invention is obtained by extracting the whole plant of the violet genus Sansikisumire (Pansie) (Viola wittrockiana Hort., V. tricolor as the original species) using a solvent. The whole plant is preferably cut or crushed appropriately.

  The bollworm extract used in the present invention is obtained by extracting a whole plant in the flowering stage of Euphorbia hirta L. using a solvent. It is preferable to use a whole plant that has been cut or pulverized as appropriate.

  The termite white willow extract used in the present invention is obtained by extracting a leaf or bark, preferably a leaf, of Salix alba L., using a solvent. It is preferable to use leaf or bark that has been appropriately cut or crushed.

  The European raspberry extract used in the present invention is obtained by extracting a fruit of the genus Rubiaceae (Rubus idaeus L.) using a solvent. It is preferable to use fruits that have been appropriately cut or ground.

  The Japanese red pine extract used in the present invention is obtained by extracting cones of Pinus sylvestris L. using a solvent. The cone is preferably cut or pulverized appropriately.

  The cypress extract used in the present invention is obtained by extracting a leaf or fruit, preferably a leaf, of a genus Vaccinium myrtillus L. using a solvent. It is preferable to use leaf or fruit appropriately cut or crushed.

  The Angelica extract used in the present invention is obtained by extracting leaves, seeds, roots or rhizomes, preferably roots or seeds, using a solvent, Angelica archangelica L. . It is preferable to use leaves, seeds, roots or rhizomes that have been appropriately cut or ground.

  The centifolia rose extract used in the present invention is obtained by extracting a flower of the Rosaceae genus Centifolia rose (Cabage Rose) (Rosa centifolia L.) using a solvent. It is preferable to use flowers that have been appropriately cut or crushed.

  The lime extract used in the present invention is obtained by extracting a fruit of Citrus aurantifolia (Christm.) Swingle using a solvent. It is preferable to use fruits that have been appropriately cut or ground.

  The extract of Bebuia awaranedae used in the present invention is obtained by extracting bark of Tabebuia avellanedae Lorentz ex Griseb using a solvent. The bark is preferably cut or crushed appropriately.

  The Eupatium purpureum extract used in the present invention is obtained by extracting the roots of the genus Eupatorium purpureum L. using a solvent. The root is preferably cut or crushed appropriately.

  The devil's claw extract used in the present invention is obtained by extracting the root of Harpagophytum procumbens DC., A sesame plant, using a solvent. The root is preferably cut or crushed appropriately.

  Solvents used in the production of the specific plant extract used in the present invention include water, lower alcohols such as ethanol, propyl alcohol, isopropyl alcohol, butanol, isobutanol, propylene glycol, 1,3-butylene glycol, 1,2 -Butylene glycol, 1,4-butylene glycol, 1,5-pentanediol, 1,2-pentanediol, 1,3-pentanediol, 1,4-pentanediol, 1,3,5-pentanetriol, glycerin, Low polarities such as polyhydric alcohols such as polyethylene glycol (molecular weight 100 to 100,000), acetone, ethyl acetate, diethyl ether, dimethyl ether, ethyl methyl ether, dioxane, acetonitrile, xylene, benzene, chloroform, carbon tetrachloride, phenol, toluene, etc. Solvent, acid (hydrochloric acid, sulfur , Nitric acid, phosphoric acid, formic acid, an alkali (sodium hydroxide) and acetic acid, potassium hydroxide, calcium hydroxide, one or two or more single solvents or mixed solvents thereof selected from ammonia, etc.) or the like.

In producing a specific plant extract used in the present invention, the extraction condition can be arbitrarily set as long as the extraction temperature is not less than the freezing point and not more than the boiling point of the solvent to be used, specifically −4 ° C. To 150 ° C. Further, the pressure applied for extraction is appropriately set within the range of 1.0 to 2.5 kg / cm ² . In addition, the weight ratio of the solvent to the raw material plant can be arbitrarily set within the range of 4: 1 to 1: 100, specifically the raw material: solvent, but the weight ratio of 1: 5 to 1:20 in particular. Is preferred. The extraction time is not particularly limited except for an extremely short time such as within one hour, and is in the range of several days to several weeks.

  As the specific plant extract used in the present invention, it is also possible to use a further purified extract obtained from the above-mentioned solvent and extraction conditions. Specific purification methods include filtration methods using filter paper, filter aids, membrane filters, etc., liquid separation operation methods, distillation methods, sublimation methods, precipitation methods, recrystallization methods, centrifugal separation methods, and vacuum concentration methods. , PH adjustment, salting out and the like, and one or more of these methods are selected.

  As the trypsin inhibitor of the present invention, the above-mentioned specific plant extract can be used as it is, water, alcohols, polyhydric alcohols, surfactants, acids, alkalis, thickeners, excipients. A trypsin inhibitor can be prepared by appropriately adding a preservative or the like to the plant extract. As content of the specific plant extract in the said trypsin inhibitor, it is at least 0.0001 mass% or more, Preferably it is 0.01-80.0 mass%, Most preferably, it is the range of 1.0-50.0 mass%. Examples of the dosage form of the trypsin inhibitor include liquid, solid, powder, granule, pellet, gel, mucous, mousse and the like, and further impregnated with a suitable carrier such as wet tissue Are used in the same way.

  The trypsin inhibitor of the present invention is used for pharmaceuticals for oral administration or parenteral administration, as well as external medicines such as ointments, lotions, creams, emulsions, quasi-drugs, cleaning cosmetics, wet tissue for baby wipes and babies. It can be blended and used as an active ingredient in foods represented by powders, sanitary sheets, care sheets, and health foods. The compounding amount of the trypsin inhibitor may be at least 0.001% by mass or more, preferably in the range of 0.1 to 75.0% by mass.

  In addition to the aforementioned trypsin inhibitor, which is an essential component, it is exemplified in the following for oral or parenteral pharmaceuticals, topical pharmaceuticals, quasi drugs, cleaning cosmetics and foods containing the trypsin inhibitor of the present invention. A variety of functionalities can be obtained by optionally using formulation-adjusting ingredients such as film-forming agents, physiologically active ingredients, colorants, surfactants, fragrances, excipients, preservatives, and antibacterial agents as additives. An excellent preparation can be constructed. The content of the components and additives in various preparations is generally used in a concentration range of 0.0001 to 50% by mass. The following components or additives may be added in advance during the production process of the preparation or may be added during the production, and may be appropriately selected in consideration of workability.

  The film forming agent used in the present invention can be arbitrarily selected as long as it is a compound having a property of forming a normal film. For example, avocado oil, almond oil, fennel oil, sesame oil, olive oil, orange oil, orange Rafah oil, sesame oil, cacao oil, chamomile oil, carrot oil, cucumber oil, beef tallow fatty acid, kukui nut oil, safflower oil, shea fat, liquid shea fat, soybean oil, camellia oil, corn oil, rapeseed oil, persic oil, castor Oil, cottonseed oil, peanut oil, turtle oil, mink oil, egg yolk oil, palm oil, palm kernel oil, molasses, coconut oil, beef tallow, lard, squalene, squalane, pristane or hydrogenated products of these oils (cured oil, etc. ) Etc., beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, can Waxes such as lila wax, montan wax, shellac wax, rice wax, mineral oils such as liquid paraffin, petrolatum, paraffin, ozokelide, ceresin, microcristan wax, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid , Linoleic acid, linolenic acid, docosahexaenoic acid, eicosapentaenoic acid, natural fatty acid such as 12-hydroxystearic acid, undecylenic acid, tall oil, lanolin fatty acid, isononanoic acid, caproic acid, 2-ethylbutanoic acid, isopentanoic acid, 2-methyl Fatty acids such as synthetic fatty acids such as pentanoic acid, 2-ethylhexanoic acid and isopentanoic acid.

  Polyether-modified silicone (polyoxyethylene / methylpolysiloxane copolymer, poly (oxyethylene / oxypropylene) methylpolysiloxane copolymer, etc.), oxazoline-modified organopolysiloxane, alkyl-modified organopolysiloxane, styryl ketone silicone derivative, Dimethylpolysiloxane, methylphenylpolysiloxane, epoxy-modified silicone, fluorine-modified silicone, alcohol-modified silicone, alkyl-modified silicone, alkoxy-modified silicone, amino-modified silicone, ammonium-modified polymer silicone, organopolysiloxane, methylphenylpolysiloxane, polysiloxane , Poly (N-acylalkylenimine) modified silicone, dimethylpolysiloxane, methylphenylpolysiloxane, nitrogen-containing Kuryl-silicone graft copolymer, decamethylcyclopentasiloxane, fluorine-substituted alkyl-modified silicone, organopolysiloxanylsilylalkyl-modified silicone, tricyclic diterpenecarboxylic acid-modified silicone, trifluoroalkyl-modified silicone, divinylpolydimethyl Siloxane, dihydrogenopolydimethylsiloxane, dihydrogenopolydimethylsiloxane divinylpolydimethylsiloxane polymer, trimethylsiloxysilicic acid, polyoxypropylene / methylpolysiloxane copolymer, ethylpolysiloxane, ethylmethylpolysiloxane, ethylphenylpolysiloxane, Octamethylcyclotetrasiloxane, diorganopolysiloxane, octamethylcyclotetrasiloxane, tetramethyltetraphenylteto Cyclosiloxane, polyether-modified polysiloxane, amino-modified polysiloxane, epoxy-modified polysiloxane, fluorine-modified polysiloxane, alcohol-modified polysiloxane, alkyl-modified polysiloxane, dodecamethylcyclohexasiloxane, laurylmethicone copolyol, aminoethyl Examples thereof include silicone compounds such as aminopropylsiloxane / dimethylsiloxane copolymer and eugenol-modified silicone.

  The physiologically active ingredient used in the present invention can be arbitrarily selected as long as it is a compound or extract having any useful physiological activity for a living body. For example, p-aminobenzoic acid derivatives, salicylic acid derivatives, benzenesulfone Amide derivatives, imidazole derivatives, naphthalene derivatives, hydroxyanthranilic acid or salts thereof and derivatives thereof, anthranilic acid derivatives, coumarin derivatives, amino acid derivatives (2-amino-3- [1-carboxyl-2- (1H-imidazole- 4-yl) ethyl] aminobutanoic acid, 2-amino-3- [1-carboxyl-2- (1H-imidazol-4-yl) ethyl] aminobutanoic acid hydrochloride, 2-amino-3- [1-carboxyl -2- (1H-imidazol-4-yl) ethyl] aminobutanoic acid sodium salt, 2-amino-3- [1-carboxyl-2- (1H-imidazol-4-yl) ethyl] potassium aminobutanoate Salt), benzo Riazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives, nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives, ascorbic acid or salts thereof and derivatives thereof (phosphate-L-ascorbine) Magnesium phosphate, ascorbyl palmitate, ascorbyl dipalmitate, hydroxyproline phosphate ascorbate, 5-o-α-D-glucopyranosyl-L-ascorbic acid, sodium salt of L-ascorbic acid phosphate, phosphorus L-ascorbate Acid ester potassium salt, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid phosphate calcium calcium salt, L-ascorbic acid phosphate aluminum salt, L-ascorbic acid sulfate sodium Umum salt, L-ascorbic acid potassium salt, L-ascorbic acid magnesium salt, L-ascorbic acid calcium salt, L-ascorbic acid sulfate aluminum salt, L-ascorbic acid sodium salt, L-ascorbic acid Potassium salt, magnesium L-ascorbate, calcium L-ascorbate, aluminum L-ascorbate, 6-o-α-D-galactopyranosyl-L-ascorbic acid, 2-o-β-D- Galactopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid phosphate sodium salt, L-ascorbic acid sulfate sodium salt, 6-o-acyl ascorbic acid phosphate sodium salt Salt, 6-o-acyl ascorbic acid phosphate ammonium salt, 6-o-acyl ascorbyl phosphate Acid ester isopropanolamine salt, 3-o-isopropyl-L-ascorbic acid, 6-o-alkylascorbic acid phosphate potassium salt, 6-o-alkylascorbic acid phosphate calcium salt, 6-o-alkylascorbic acid Phosphoric acid ester barium salt, 6-o-alkyl ascorbic acid phosphate ammonium salt, 6-o-alkyl ascorbic acid phosphate monoethanolamine salt, 6-o-alkyl ascorbic acid phosphate diethanolamine salt, 6-o -Alkylascorbic acid phosphate triethanolamine salt, 6-o-alkylascorbic acid phosphate monoisopropanolamine salt, 6-o-alkylascorbic acid phosphate diisopropanolamine salt, 6-o-alkylascorbic acid phosphorus Acid ester triisopropanolamine salt , 3-o-glycosyl-L-ascorbic acid, 6-o-β-D-galactopyranosyl-L-ascorbic acid, ascorbic acid phosphate cholesterol ester, palmitic acid-L-ascorbyl, isopalmitic acid-L- Ascorbyl, dipalmitic acid-L-ascorbyl, diisopalmitic acid-L-ascorbyl, stearic acid-L-ascorbyl, isostearic acid-L-ascorbyl, distearic acid-L-ascorbyl, diisostearic acid-L-ascorbyl, myristic acid- L-ascorbyl, isomyristic acid-L-ascorbyl, dimyristic acid-L-ascorbyl, diisomyristic acid-L-ascorbyl, 2-ethylhexanoic acid-L-ascorbyl, di-2-ethylhexanoic acid-L-ascorbyl , Oleic acid-L-ascorbic acid, 2-o-α-D-glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L-ascorbic acid, 2-o-α-D-mal Triosyl-L-ascorbic acid, 3-o-α-D-glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L-ascorbic acid, 2-o-α-D-maltotriosyl-L -Ascorbic acid, L-ascorbic acid tetraisopalmitate, L-ascorbic acid tetralaurate, L-ascorbic acid tetra-2-ethylhexanoate, L-ascorbic acid tetraoleate, 5,6-isopropyl Reden-L-ascorbic acid, L-ascorbic acid retinol ester, L-ascorbic acid-DL-tocopherol phosphate ester, L-3-o-ethylascorbic acid, L-ascorbic acid tristearate, L-ascorbic acid tripalmi Tate, L-ascorbic acid trioleate, L-ascorbic acid triphosphate, 2-o-ascorbyl cinnamate, 2-o-ascorbyl ferrate, 2-o-ascorbi Caffeate, 2-o-ascorbyl cinnapeate, 2-o- [6-palmitoyl ascorbyl] -4'-acetoxyferrate, DL-α-tocopherol-2-L-ascorbic acid phosphate diester, ascorbic acid inositol binding derivative Ascorbic acid phosphoramide derivatives, ascorbic acid arbutin conjugates, ascorbyl phosphoryl cholesterol, chromanyl ascorbic acid derivatives, ascorbic acid sialic acid derivatives, etc.).

  Tocopherol or salts thereof and derivatives thereof (α-tocopherol, β-tocopherol, γ-tocopherol, δ-tocopherol, ε-tocopherol, α-tocopheryl retinoate, aminomethylated tocopherol, hydroxymethylated tocopherol, tocopheryl phosphate ester , Tocopherol acetate, tocopherol nicotinate, tocopherol succinate, tocopherol linoleate, tocopherol orotate, DL-α-tocopheryl glucoside, DL-α-tocopheryl maltoside, DL-β-tocopheryl glucoside, DL-β-toco Ferryl maltoside, DL-γ-tocopheryl glucoside, DL-γ-tocopheryl maltoside, DL-δ-tocopheryl glucoside, DL-δ-tocopheryl maltoside, D-α-tocopheryl glucoside, D-α- Tocopheryl maltoside, D- β-tocopheryl glucoside, D-β-tocopheryl maltoside, D-γ-tocopheryl glucoside, D-γ-tocopheryl maltoside, D-δ-tocopheryl glucoside, D-δ-tocopheryl maltoside, L -α-tocopheryl glucoside, L-α-tocopheryl maltoside, L-β-tocopheryl glucoside, L-β-tocopheryl maltoside, L-γ-tocopheryl glucoside, L-γ-tocopheryl maltoside, L-δ-tocopheryl glucoside, L-δ-tocopheryl maltoside, 1- (sulfoethylamino) -3- (α-tocopheryl-6-yloxy) propan-2-ol, 1- (carboxypropylamino) ) -3- (α-Tocopheryl-6-iroxy) propan-2-ol hydrochloride, S- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl] cysteine, S- [ 3- (α-Tocopheryl-6-iroxy) -2-hydroxypropyl] -γ-glutamyl system Nilglycine, N- [3- (α-tocopheryl-6-yloxy) -2-hydroxypropyl] aspartic acid, N- [3- (α-tocopheryl-6-yloxy) -2-hydroxypropyl] glutamic acid Etc.), tocotrienol or a salt thereof and derivatives thereof (α-tocotrienol, β-tocotrienol, γ-tocotrienol, δ-tocotrienol, tocotrienol acetate, tocotrienol nicotinate, tocotrienol succinate, tocotrienol linoleate, tocotrienol orotate, etc.) Acid or its derivatives (2-methoxymethyl-hydroxy-4H-pyran-4-one, 2-ethoxymethyl-5-hydroxy-4H-pyran-4-one, 2-benzoyloxymethyl-5-hydroxy-4H- Pyran-4-one, 2-cinnamoyloxymethyl-5-hydroxy-4H-pyran-4-one, 2-phenoxymethyl-5- Roxy-4H-pyran-4-one, kojic acid glycoside, geranylgeranylacetone, kojic acid monobutyrate, kojic acid monocaprate, kojic acid monopalmitate, kojic acid monostearate, kojic acid monocinnamate, kojic acid monobenzoate , Kojic acid dibutyrate, kojic acid dipalmitate, kojic acid distearate, kojic acid dioleate, etc.).

  Oxybenzone, benzophenone, guaiazulene, shikonin, baicalin or a salt thereof and derivatives thereof, baicalein or a salt thereof and derivatives thereof, berberine or a salt thereof and derivatives thereof, chrysin or a salt thereof and derivatives thereof, apigenin or a salt thereof and them Derivatives, luteolin or salts thereof and derivatives thereof, acacetin or salts thereof and derivatives thereof, diosmethine or salts thereof and derivatives thereof, kaempferol or salts thereof and derivatives thereof, trifolin or salts thereof and derivatives thereof, astra Galine or a salt thereof and derivatives thereof, quercetin or a salt thereof and derivatives thereof, quercitrin or a salt thereof and derivatives thereof, isoquercitrin or a salt thereof and derivatives thereof , Rutin or a salt thereof and derivatives thereof, morin or a salt thereof and derivatives thereof, myricetin or a salt thereof and derivatives thereof, myristitrin or a salt thereof and derivatives thereof, datiscetin or a salt thereof and derivatives thereof, quercetagetin or a derivative thereof Salts and derivatives thereof, isorhamnetin or salts thereof and derivatives thereof, pinocembrin or salts thereof and derivatives thereof, naringenin or salts thereof and derivatives thereof, hesperetin or salts thereof and derivatives thereof, eriodictyol or salts thereof and the like Derivatives, pinobankin or salts thereof and derivatives thereof, aromadendrine or salts thereof and derivatives thereof, engelitin or salts thereof and derivatives thereof, taxofolin or salts thereof and derivatives thereof , Astilbine or a salt thereof and derivatives thereof, amperopsin or a salt thereof and derivatives thereof, glutathione or a salt thereof and derivatives thereof, isoflavone glycoside (6-o-apiosylpuerarin-4′-o-glucoside, 6- o-glucosyl puerarin, 3'-hydroxypuerarin-4'-o-glucoside, 6-o-apiocil-3'-hydroxypuerarin), γ-pyrone glycosides (maltol-3-o- (6'-o -Apiosyl) -glucoside, maltol-3-o- (6'-o-apiosyl) -glucoside, etc.), isononyl ferrate, ellagic acid or a salt thereof and derivatives thereof (5,4-dimethylellagic acid, 3, 3'-dimethylellagic acid, 3,3 ', 4-trimethylellagic acid, 3,3', 4,4'-tetramethyl-5-methoxyellagic acid, 3-ethyl-4-methyl-5-hydroxyellagic acid , Amritoside, etc.), Lucinol, Ondisaponi , Bacmond saponin, ruscogenin, sericoside, asiaticoside, hederin, senegin, benzoic acid anilides (4-hydroxy-N- (2-hydroxyphenyl) benzoic acid amide, 4-hydroxy-N- (3-hydroxyphenyl) Benzamide, 4-hydroxy-N- (4-hydroxyphenyl) benzamide, 3,5-di-t-butyl-4-hydroxy-N- (4-hydroxyphenyl) benzamide, 3,5-di-t-butyl- 4-hydroxy-N- (3-hydroxyphenyl) benzamide, 3,5-di-t-butyl-4-hydroxy-N- (2-hydroxyphenyl) benzamide, etc.), diphenylpyrine, cyproheptadine, triprolidine, dimethindene, Ozagrel, isothipentyl, iproheptin, homochlorcyclidine, alimemazine, bucillamine, oxytosamide, vidarabine, xanthotoxol, phenylmercury Sakurorofen, mercuric oxide, mercurous chloride, hydrogen peroxide, zinc peroxide, placenta (bovine, porcine, equine, ovine, etc.) extract.

  Hydroquinone or its salts and derivatives thereof (hydroquinone α-D-glucose, hydroquinone β-D-glucose, hydroquinone α-L-glucose, hydroquinone β-L-glucose, hydroquinone α-D-galactose, hydroquinone β-D-galactose , Hexose sugar glycosides such as hydroquinone α-L-galactose, hydroquinone β-L-galactose, hydroquinone α-D-ribose, hydroquinone β-D-ribose, hydroquinone α-L-ribose, hydroquinone β-L-ribose , 5-quinone glycosides such as hydroquinone α-D-arabinose, hydroquinone β-D-arabinose, hydroquinone α-L-arabinose, hydroquinone β-L-arabinose, hydroquinone α-D-glucosamine, hydroquinone β-D-glucosamine , Hydroquinone α-L-Glucosamine, Hydroquinone β-L- Amino sugar glycosides such as lucosamine, hydroquinone α-D-galactosamine, hydroquinone β-D-galactosamine, hydroquinone α-L-galactosamine, hydroquinone β-L-galactosamine, hydroquinone α-D-glucuronic acid, hydroquinone β-D- Glucuronic acid, hydroquinone α-L-glucuronic acid, hydroquinone β-L-glucuronic acid, hydroquinone α-D-galacturonic acid, hydroquinone β-D-galacturonic acid, hydroquinone α-L-galacturonic acid, hydroquinone β-L-galacturonic acid Hydroquinone glycosides such as uronic acid glycosides, hydroquinone benzyl ether, 4-β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) butane, 5-β-D-glucopyranosyl Oxy-1- (4-hydroxyphenoxy) pentane, 6-β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) ) Hexane, 2-β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) propane, 2-β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) butane, 2-β -Hydroquinone hydroxyalkyl ether glycosides such as -D-glucopyranosyloxy-1- (4-hydroxyphenoxy) propan-3-ol).

  Isonitrile antibiotics such as isonitrine A, isonitrine B, isonitrine C, isonitrine D, isonitrinic acid E, isonitric acid F, dermadein, tricobilidein, etc. Acid, p-geranylorceric acid ethyl ester geranylorcinol, p-farnesylorceric acid, p-farnesylorceric acid ethylester farnesylorcinol, p-dodecanylorceric acid, p-dodecanylorceric acid ethylester Dodecanylorcinol, p-tetradecanylorceric acid, p-tetradecanylorceric acid ethyl ester tetradecanylorcinol, p-hexadecanylorceric acid, p-hexadecanylorceric acid ethyl ester hexa De Nylorcinol, p-undecanylorceric acid, p-undecanylorceric acid ethyl ester undecanylorcinol, p-tridecanylorceric acid, p-tridecanylorceric acid ethyl ester undecanylo Lucinol, p-pentadecanylorceric acid, p-pentadecanylorceric acid ethyl ester pentadecanylorcinol, ethylhexylorceric acid, p-ethylhexylorceric acid ethylester ethylhexylorcinol, p-cyclohexylmethylorserine Acid, p-cyclohexylmethylorceric acid ethyl ester cyclohexylmethylorcinol, p-hydroxyethylhexylorceric acid methyl ester, p-hydroxyethylhexylorceric acid hydroxyethylhexylorcinol, etc.), umbelic acid, blef Erdin, oxydesveratrol, resorcinol derivative (4-cyclohexylresorcinol), 3-hydroxyketone compound (1,5-bis (p-hydroxyphenyl) -2-hydroxypentan-4-one, 1,5-bis (o , P-dihydroxyphenyl) -2-hydroxypentan-4-one, 1,5-bis (p-hydroxyphenyl-m-methoxyphenyl) -2-hydroxypentan-4-one, etc.), 1,3-diketone compounds (1,5-bis (p-hydroxyphenyl) -2,4-pentanedione, 1,5-bis (o, p-dihydroxyphenyl) -2,4-pentanedione, 1,5-bis (p-hydroxy) Phenyl-m-methoxyphenyl) -2,4-pentanedione), bishydroxybenzyl amides, γ-aminobutyric acid or its derivatives (N-methyl-γ-aminobutyric acid, N-dimethyl-γ-aminobutyric acid, γ -Aminobutyric acid oleyl ester, etc.), lucinol.

  Lobeline or lobeline derivatives, liquiritin derivatives (such as liquiritin-α-glucoside and liquiritin-α-maltoside), phenylchroman derivatives, chromone derivatives (2-butylchromone, 2-pentylchromone, 2-heptylchromone, 2-nonylchromone, 2- Hexadecylchromone, 2- (1-ethylpentyl) chromone, 2-butyl-7-methoxychromone, 2-pentyl-7-methoxychromone, 2-heptyl-7-methoxychromone, 2-nonyl-7-methoxychromone, 2-pentadecyl-7-methoxychromone, 2- (1-ethylpentyl) -7-methoxychromone, 7-hydroxy-2-methylchromone, 7-hydroxy-2-butylchromone, 7-hydroxy-2-pentylchromone, 7-hydroxy-2-heptylchromone, 7-hydroxy-2-nonylchromone, 7-hydroxy-2-pentadecylchromone, 7-hydroxy-2- (1-ethylpentyl) Chromone), azelaic acid derivatives (azelaic acid monoalkyl ester, azelaic acid dialkyl ester, etc.), phosphatidylglucosamine, lysophosphatidylglucosamine, phenylhydroquinone, 3-β-D-glucopyranosyl manur, 3-β-D-malto Pyranosyl manur, substituted amino acid derivatives (DL-N-formyl-3- (1-naphthyl) alanine, DL-N-acetyl-3- (1-naphthyl) alanine, DL-N-propionyl-3- (1- Naphthyl) alanine, DL-N-butyryl-3- (1-naphthyl) alanine, DL-N-isobutyryl-3- (1-naphthyl) alanine, DL-N-valeryl-3- (1-naphthyl) alanine, DL -N-Isovaleryl-3- (1-naphthyl) alanine, DL-N- (2-methylvaleryl) -3- (1-naphthyl) alanine, DL-N- (3-methylvaleryl) -3- (1-naphthyl) Alanine, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine, DL-N-t-butylacetyl-3- (1- (Futyl) alanine, DL-N-pivaloyl-3- (1-naphthyl) alanine, DL-N-caproyl-3- (1-naphthyl) alanine, DL-N- (2-ethylhexanoyl) -3- (1 -Naphthyl) alanine, DL-N- (2-methylhexanoyl) -3- (1-naphthyl) alanine, DL-N-heptanoyl-3- (1-naphthyl) alanine, DL-N-octanoyl-3- ( 1-naphthyl) alanine, DL-N- (2-propylpentanoyl) -3- (1-naphthyl) alanine, DL-N-nonanoyl-3- (1-naphthyl) alanine, DL-N-decanoyl-3- (1-naphthyl) alanine, DL-N-undecanoyl-3- (1-naphthyl) alanine, DL-N-dodecanoyl-3- (1-naphthyl) alanine, DL-N-tridecanoyl-3- (1-naphthyl) Alanine, DL-N-tetradecanoyl-3- (1-naphthyl) alanine, DL-N-pentadecanoyl-3- (1-naphthyl) alanine, DL-N-hexadecanoyl-3- (1-naphthyl) ) Alanine, DL-N-Heptadecanoyl-3- (1-naphthyl) alanine, DL -N-octadecanoyl-3- (1-naphthyl) alanine, DL-N-nonadecanoyl-DL-3- (1-naphthyl) alanine, DL-N-icosanoyl-3- (1-naphthyl) alanine, DL- N-Acroyl-3- (1-naphthyl) alanine, DL-N-crotoniloyl-3- (1-naphthyl) alanine, DL-N-methacryloyl-3- (1-naphthyl) alanine, DL-N-vinylacetyl- 3- (1-naphthyl) alanine, DL-N-cyclopropanoyl-3- (1-naphthyl) alanine, DL-N- (2-pentenoyl) -3- (1-naphthyl) alanine, DL-N- ( 4-Pentenoyl) -3- (1-naphthyl) alanine, DL-N- (2-hexenoyl) -3- (1-naphthyl) alanine, DL-N- (3-hexenoyl) -3- (1-naphthyl) Alanine, DL-N- (2-Methyl-3-pentenoyl) -3- (1-naphthyl) alanine, DL-N-cyclohexenoyl-3- (1-naphthyl) alanine, DL-N- (10 -Undecenoyl) -3- (1-naphthyl) alanine, DL-N-linoleyl-3- (1-naphthyl) alanine, DL-N-hydride Xylacetyl-3- (1-naphthyl) alanine, DL-N- (6-hydroxycaproyl) -3- (1-naphthyl) alanine, DL-N- (8-hydroxyoctanoyl) -3- (1-naphthyl) ) Alanine, DL-N- (9-hydroxynonanoyl) -3- (1-naphthyl) alanine, DL-N- (10-hydroxydecanoyl) -3- (1-naphthyl) alanine, DL-N- ( 11-hydroxyundecanoyl) -3- (1-naphthyl) alanine, DL-N- (12-hydroxydecanoyl) -3- (1-naphthyl) alanine, DL-N-benzoyl-3- (1-naphthyl) ) Alanine, DL-N- (2-hydroxybenzoyl) -3- (1-naphthyl) alanine, DL-N- (3-hydroxybenzoyl) -3- (1-naphthyl) alanine, DL-N- (4- Hydroxybenzoyl) -3- (1-naphthyl) alanine, DL-N- (o-toluyl) -3- (1-naphthyl) alanine, DL-N- (m-toluyl) -3- (1-naphthyl) alanine DL-N- (p-toluyl) -3- (1-naphthyl) alanine, DL-N- (1-naphthyl) -3- (1-naphthyl) alanine, DL-N- (2-naphthoyl) -3- (1-naphthyl) alanine, DL-N- (2-carboxybenzoyl) -3- (1-naphthyl) alanine, DL-N- (3-carboxybenzoyl)- 3- (1-Naphtyl) alanine, DL-N- (4-Carboxybenzoyl) -3- (1-naphthyl) alanine, DL-N- (2-Picolyloyl) -3- (1-naphthyl) alanine, DL- N- (3-Picoliloyl) -3- (1-naphthyl) alanine, DL-N- (4-Picolyloyl) -3- (1-naphthyl) alanine, DL-N-phenylacetyl-3- (1-naphthyl) Alanine, DL-N- (2-phenylpropanoyl) -3- (1-naphthyl) alanine, DL-N- (3-phenylbutyryl) -3- (1-naphthyl) alanine, DL-N- (4 -Methylvaleryl) -3- (1-naphthyl) alanine, DL-N-valeryl-3- (1-naphthyl) alanine, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alaninamide, DL- N- (4-methylvaleryl) -3- (1-naphthyl) alanine methyl ester, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine ester Tyl ester, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine propyl ester, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine-N-butyl ester, DL-N -(4-Methylvaleryl) -3- (1-naphthyl) alanine pentyl ester, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine isopropyl ester, DL-N- (4-methylvaleryl) -3 -(1-naphthyl) alanine isobutyl ester, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine-t-butyl ester, etc.).

  Benzolactam derivatives, indolactam derivatives, cedrol, guaiool, 1- (4-hydroxyphenthio) -2-propanol, β-lactoglobulin, 2-methoxy-5-methylphenol, 5-ethyl-2-methoxyphenol, 5 -N-propyl-2-methoxyphenol, 5-N-butyl-2-methoxyphenol, 5-N-hexyl-2-methoxyphenol, 5-N-heptyl-2-methoxyphenol, 5-N-decyl-2 -Methoxyphenol, 5- (1,1-dimethylpropyl) -2-methoxyphenol, 5- (1,1-dimethylbutyl) -2-methoxyphenol, 5- (1,1-dimethylethyl) -2-methoxy Phenol, 2-methoxy-5- (1-methylpentyl) phenol, 2-methoxy-5- (1-methylhexyl) phenol, 2-methoxy-5- (3-methylhexyl) phenol, 2-methoxy-5- (6-methylheptyl) phenol, 5- (1,3-dimethylheptyl) -2-methyl Xylphenol, malvelin, feruginol, sugiol, cryptojaponol, 1,5-bis [p-hydroxyphenyl] -1,4-pentadien-3-one, 1,5-bis [o-hydroxyphenyl] -1,4 -Pentadien-3-one, 1,5-bis [2,4-dihydroxyphenyl] -1,4-pentadien-3-one, 1,5-bis [3-methoxy-4-hydroxyphenyl] -1, 4-pentadien-3-one, haginin, agrimophor, agrimol, hydrangenol or derivatives thereof, alkylresorcinol or derivatives thereof (such as 4-N-butylresorcinol), aristrone, caramenenes (caramenene, 7-hydroxycaramenene) , 5-hydroxycaramenene, 7-methoxycaramenene, etc.), trans-umberic acid, N-α-benzoyl-L-arginine, N-α-benzoyl-L-arginine ethyl ester or N-α-benzoyl-L -Arginine ethyl ester, 5-methyl-2 (3H) -furanone, 2-buten-4-olide, 2-hydroxymethylfuran, 2,5-dimethyl-4-hydroxy-3 (2H) -furanone, 2-formyl Furan, 3-formylfuran, methyl α-furyl ketone, furfuryl acetate, 2-hydroxy-3-methyl-2-cyclopenten-1-one, 2-hydroxy-3,5-dimethyl-2-cyclopenten-1-one, 2,5-dimethyl-4-hydroxy-3 (2H) -thiophenone, 2-hydroxy-3-ethyl-2-cyclopenten-1-one, tetronic acid, pentanedione, iminodibenzyls (2,2'-imino Dibenzyl, imipramine, imipramine hydrochloride, desipramine, desipramine hydrochloride, chlorimipramine, trimipramine, etc.), dibenzocycloheptadiene (amitriptyline, amitriptyline hydrochloride, nortriptyline, noxiptylline) ), Tetrahydrocoparol glycosides (ketotifen fumarate, labda-8 (17), 13-diene-15-ol, tetrahydromanur, tetrahydrocoparol, tetrahydrocoparol glucoside, tetrahydrocoparol galactoside, tetrahydrocopalol malto Sid, tetrahydrocoparol cellobioside, tetrahydrocoparol maltotrioside, etc.), spiroether compound, piochelin, phenothiazine compound, promethazine, alimemazine, alimemazine tartrate, triflupromazine, levomepromazine, chlorpromazine, cyclandelate.

  4-carboxymethyloxybenzoic acid, 4-carboxymethyloxy-2-hydroxybenzoic acid, 3- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- (3-carboxypropyl-1-oxy ) Benzoic acid, 4- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- (3-carboxypropyl-1-oxy) -2-methoxybenzoic acid, 5- (3-carboxypropyl- 1-oxy) -2-hydroxybenzoic acid, 4- (5-carboxypentyl-1-oxy) -2-hydroxybenzoic acid, 6- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 4 -(10-carboxydecane-1-oxy) -2-hydroxybenzoic acid, 4- (10-carbamoyldecane-1-oxy) -2-hydroxybenzoic acid, 4- (4-hydroxybutyl-1-oxy) benzoic acid Acid, 4- (4-hydroxybutyl-1-oxy) -2-hydroxybenzoic acid, 4- (4-acetoxybutyl-1-oxy) benzoic acid, 4- (4-acetic acid) Xylbutyl-1-oxy) -2-hydroxybenzoic acid, 4- (3-ethoxycarbonylpropyl-1-oxy) -2-hydroxybenzoic acid, 3- (2,3-dihydroxypropyl-1-oxy) -2- Hydroxybenzoic acid, 4- (4-methoxybutyl-1-oxy) -2-hydroxybenzoic acid, 4- (2,3-dihydroxypropyl-1-oxy) -2-hydroxybenzoic acid, 4-carboxymethyloxy- 2-hydroxybenzoic acid, 3- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 5- (3-carboxy Propyl-1-oxy) -2-hydroxybenzoic acid, 6- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- (5-carboxypentyl-1-oxy) -2-hydroxybenzoic acid 4- (4-hydroxybutyl-1-oxy) -2-hydroxybenzoic acid, 4- (10-carboxydecane-1-oxy) -2-hydroxybenzoic acid Hydroxytrimethylcyclohexanes (2-hydroxy-4- (2,2,6-trimethyl-1-yl-cyclohexane) butane, 4- (2,2,6-trimethyl-1-yl-cyclohexane) -1-butene 4- (2,2,6-trimethyl-1-yl-cyclohexane) -2-butene, 4- (2,2,6-trimethyl-1-yl-cyclohexane) butane, 3-methyl-3-hydroxy- 5- (2,2,6-trimethyl-1-yl-cyclohexane) pentane, 3-methyl-1-hydroxy-5- (2,2,6-trimethyl-1-yl-cyclohexane) pentane, 3-methyl- 5- (2,2,6-trimethyl-1-yl-cyclohexane) pentane, 3-methyl-1-hydroxy-5- (2,2,6-trimethyl-1-yl-cyclohexane) -3-pentene, 3 -Methyl-3-hydroxy-5- (2,2,6-trimethyl-1-yl-cyclohexane) -1-pentene, 3-methyl-1-hydroxy-5- (2,2,6-trimethyl-1- Yl-cyclohexane) -2-pe Nthene, 2-hydroxy-4- (2,2,6-trimethyl-1-yl-cyclohexane) butane and other monosaccharides, disaccharides or trisaccharide glycosides), escinol, parahydroxycinnamic acid-4- ( 2,2,6-Trimethyl-yl-cyclohexane) -2-butyl ester monosaccharide, disaccharide or trisaccharide glycoside, ondisaponin, bacmond saponin, ruscogenin, sericoside, asiaticoside, hederin, senegin.

  4- (2,2,6-trimethyl-1-yl-cyclohexane) -2-keto-butane, 4- (2,2,6-trimethyl-1-yl-6-cyclohexene) -2-keto-butane, 4- (2,2,6-trimethyl-1-yl-cyclohexane) -2-keto-3-butene, 4- (2,2,6-trimethyl-1-yl-6-cyclohexene) -2-keto- 3-butene (β-ionone), Lp-hydroxyphenylglycine, Dp-hydroxyphenylglycine, N-benzyloxycarbonyl-Lp-hydroxyphenylglycine, N-benzyloxycarbonyl-Dp-hydroxyphenylglycine, N-benzoyl-Lp -Hydroxyphenylglycine, N-benzoyl-Dp-hydroxyphenylglycine, N- (p-methoxybenzoyl) -Lp-hydroxyphenylglycine, N- (p-methoxybenzoyl) -Dp-hydroxyphenylglycine, N- (p- Hydroxybenzoyl) -Lp-hydroxyphenylglycine, N- (p-hydride) Xylbenzoyl) -Dp-hydroxyphenylglycine, N-acetyl-Lp-hydroxyphenylglycine, N-acetyl-Dp-hydroxyphenylglycine, N-acetyl-Lp-hydroxyphenylglycine ethyl ester, N-acetyl-Dp-hydroxyphenyl Glycine ethyl ester, N-acetyl-Lp-hydroxyphenylglycinamide, N-acetyl-Dp-hydroxyphenylglycinamide, Lp-methoxyphenylglycine, Dp-methoxyphenylglycine, Lp-methoxyphenylglycine hydrochloride, Dp-methoxyphenyl Glycine hydrochloride, 4-hydroxy-3-methoxy-L-phenylglycine, 4-hydroxy-3-methoxy-D-phenylglycine, Lp-hydroxyphenylglycine ethylamide, Dp-hydroxyphenylglycine ethylamide, N-tert- Butoxycarbonyl-Lp-hydroxyl Nilglycine, N-tert-butoxycarbonyl-Dp-hydroxyphenylglycine, N-tert-butoxycarbonyl-Lp-methoxyphenylglycine, N-tert-butoxycarbonyl-Dp-methoxyphenylglycine, N-9-fluorenylmethyloxy Carbonyl-Lp-methoxyphenylglycine, N-9-fluorenylmethyloxycarbonyl-Dp-methoxyphenylglycine, N-9-fluorenylmethyloxycarbonyl-Lp-methoxyphenylglycine benzyl ester hydrochloride, N-9- Fluorenylmethyloxycarbonyl-Dp-methoxyphenylglycine benzyl ester hydrochloride, Lp-hydroxyphenylglycinamide, Dp-hydroxyphenylglycine amide, Lp-hydroxyphenylglycine allyl ester p-toluenesulfonate, Dp-hydroxyphenylglycine Allyl ester p-to Ensulfonate, Lp-hydroxyphenylglycine benzyl ester p-toluenesulfonate, Dp-hydroxyphenylglycine benzyl ester p-toluenesulfonate, Lp-hydroxyphenylglycine ethyl ester, Dp-hydroxyphenylglycine ethyl ester, Lp -Hydroxyphenyl glycine ethyl ester hydrochloride, Dp-hydroxyphenyl glycine ethyl ester hydrochloride, Lp-hydroxyphenyl glycine methyl ester, Dp-hydroxyphenyl glycine methyl ester, 1,3-diallyl indan-2-carboxylic acids, stachybosine Pheophorbide derivatives.

  Eleucerin, isoeleucerine or 4-β-hydroxyisoeleucerin, eleucerinol, spiroketal derivative (2- (2,4-hexadinylidene) -1,6-dioxaspiro [4.5] dec-3-ene, 2- (2 -Hexynylidene) -1,6-dioxaspiro [4.4] non-3-ene, 2-((4-methylphenyl) methylidene) -6,6-dioxaspiro [4.4] non-3-ene, 2- (2-hexenylidene ) -6,6-Dioxaspiro [4.5] dec-3-ene, 2- (2-hexenylidene) -1,6-dioxaspiro [4.4] non-3-ene, 2-hexyl-1,6-dioxaspiro [4.4] Nonane, 2- (2-hexenyl) -1,6-dioxaspiro [4.4] nonane, 2- (2-hexynyl) -1,6-dioxaspiro [4.4] nonane, 2-pentyl-1,6-dioxaspiro [4.4] Nonane, 1,6-dioxaspiro [4.4] nonane, 1,6-dioxaspiro [4.5] decane, 1,7-dioxaspiro [5.5] undecane, 2,3-benzo-4,4-dimethyl-1, 6-dioxaspiro [4.4] nonane, 3,4-benzo-2-pentyl-1,6-dioxaspiro [4.4] nonane, 3,4-benzo-2-hexyl-1,6-dioxaspiro [4.4] nonane, 3, 4-Benzo-2-octyl-1,6-dioxaspiro [4.4] nonane, 2-hexyl-9,9-dimethyl-1,6-dioxaspiro [4.4] nonane, 2- (2,4-hexadiynylidene)- 1,6-dioxaspiro [4.4] non-3-ene etc.), malvalic acid, phosphonic acid derivative or salt thereof, aspergillomarasmine, aminophosphonic acid derivative or salt thereof, diphenhydramine or salt thereof, pregnenolone or derivative thereof, lutein , Farnesyl isopropanol derivative, hexahydrofarnesyl acetone, 4-benzoylamino-2-hydroxybenzoic acid, 5-benzoylamino-2-hydroxybenzoic acid, 4-benzoylaminobenzoic acid, 4- (1-naphthoylamino) -2 -Hydroxy Benzoic acid, 5- (1-naphthoylamino) -2-hydroxybenzoic acid, 4- (2-naphthoylamino) -2-hydroxybenzoic acid, 5- (2-naphthoylamino) -2-hydroxybenzoic acid 4- (1-naphthoylamino) benzoic acid, 4- (2-naphthoylamino) benzoic acid, 4-phenylaminocarbonylbenzoic acid, 4-phenylaminocarbonyl-2-hydroxybenzoic acid, 5-phenylaminocarbonyl 2-hydroxybenzoic acid, 4- (1-naphthylaminocarbonyl) benzoic acid, 4- (1-naphthylaminocarbonyl) -2-hydroxybenzoic acid, 5- (1-naphthylaminocarbonyl) -2-hydroxybenzoic acid 4- (2-naphthylaminocarbonyl) benzoic acid, 4- (2-naphthylaminocarbonyl) -2-hydroxybenzoic acid, 5- (2-naphthylaminocarbonyl) -2-hydroxybenzoic acid, hexahydrofarnesyl isopropanol derivative , Borneol-p- Droxycinnamate glucoside, Borneol-p-hydroxycinnamate maltoside, Borneol-p-hydroxycinnamate maltotrioside, Cinnamic acid-4- (2,2,6-Trimethyl-yl-cyclohexane)- 2-Butyl ester derivative.

  2,4-dihydroxybenzophenone, 1- (2,4-dihydroxyphenyl) -ethanone (2 ', 4'-dihydroxyacetophenone), 1- (2,4-dihydroxyphenyl) -1-propanone (2', 4 ' -Dihydroxypropiophenone), 1- (2,4-dihydroxyphenyl) -1-butanone, 1- (2,4-dihydroxyphenyl) -1-pentanone, 1- (2,4-dihydroxyphenyl) -1- Hexanone, 1- (2,4-dihydroxyphenyl) -1-heptanone, 1- (2,4-dihydroxyphenyl) -1-octanone, 1- (2,4-dihydroxyphenyl) -1-nonanone, 1- ( 2,4-dihydroxyphenyl) -1-decanone, 1- (2,4-dihydroxyphenyl) -1-undecanone, 1- (2,4-dihydroxyphenyl) -1-dodecanone, 1- (2,4-dihydroxy Phenyl) -1-tetradecanone, 1- (2,4-dihydroxyphenyl) -1-hexadecanone, 1- (2,4-dihydroxyphenyl) -1-oct Tadecanone, 1- (2-hydroxy-4-methoxyphenyl) -ethanone (2'-hydroxy-4'-methoxyacetophenone), 1- (2-hydroxy-4-methoxyphenyl) -1-propanone (2'-hydroxy -4'-methoxypropiophenone), 1- (2-hydroxy-4-methoxyphenyl) -1-butanone, 1- (2-hydroxy-4-methoxyphenyl) -1-pentanone, 1- (2-hydroxy -4-methoxyphenyl) -1-hexanone, 1- (2-hydroxy-4-methoxyphenyl) -1-heptanone, 1- (2-hydroxy-4-methoxyphenyl) -1-octanone, 1- (2- Hydroxy-4-methoxyphenyl) -1-nonanone, 1- (2-hydroxy-4-methoxyphenyl) -1-decanone, 1- (2-hydroxy-4-methoxyphenyl) -1-undecanone, 1- (2 -Hydroxy-4-methoxyphenyl) -1-dodecanone, 1- (2-hydroxy-4-methoxyphenyl) -1-tetradecanone, 1- (2-hydroxy-4-methoxy) Phenyl) -1-hexadecanone, 1- (2-hydroxy-4-methoxyphenyl) -1-octadecanone, 1- (4-hydroxy-2-methoxyphenyl) -ethanone (4′-hydroxy-2′-methoxyacetophenone) 1- (4-hydroxy-2-methoxyphenyl) -1-propanone (4′-hydroxy-2′-methoxypropiophenone), 1- (2,4-dimethoxyphenyl) -ethanone (2 ′, 4 ′ -Dimethoxyacetophenone), 1- (2,4-dimethoxyphenyl) -1-propanone (2 ', 4'-dimethoxypropiophenone), lactone derivative (1,6-dioxaspiro [4.4] nonane-2,7-dione 1,6-dioxaspiro [4.5] decane-2,7-dione, 4-tridecanolide, 4-dodecanolide, 4-undecanolide, 4-decanolide, 4-nonanolide, 4-octanolide, 4-heptanolide, 5-dodecanolide, 5 -Undecanolide, 5-decanolide, 5-nonanolide, 5-octanolide , 2-undecen-4-olide, 2-decene-4-olide, 2-nonen-4-olide, 2-hepten-4-olide, 2-undecen-5-olide, 2-decene-5-olide, 2 -Nonene-5-olide, 2-octene-5-olide, 4-methyl-4-dodecanolide, 4-methyl-4-undecanolide, 4-methyl-4-decanolide, 4-methyl-4-nonanolide, 4-methyl -4-heptanolide, 5-methyl-5-dodecanolide, 5-methyl-5-undecanolide, 5-methyl-5-decanolide, 5-methyl-5-nonanolide, 5-methyl-5-octanolide, 2-methoxycarbonyl- 4-dodecanolide, 2-methoxycarbonyl-4-undecanolide, 2-methoxycarbonyl-4-decanolide, 2-methoxycarbonyl-4-nonanolide, 2-methoxycarbonyl-4-heptanolide, 2-methoxycarbonyl-5-undecanolide, 2 -Methoxycarbonyl-5-decanolide, 2-methoxycarbonyl-5-nonanolide, 2-metho Cycarbonyl-5-octanolide, 2-allyl-4-undecanolide, 2-allyl-5-decanolide, 2-allyl-4-nonanolide, 2-pentyl-4-undecanolide, 2-pentyl-4-nonanolide, 2-methyl -4-undecanolide, 2-methyl-4-nonanolide, 2- (4-hydroxybutyl) -4-undecanolide, 2- (4-hydroxybutyl) -4-nonanolide, 2- (4-hydroxybutyl) -5- Decanolide, 5-propyloxy-4-pentanolide, 5-allyloxy-4-pentanolide, 5- (2-hydroxyethoxy) -4-pentanolide, 8-hydroxy-4-octanolide, 6-propyloxy-5-hexanolide, 6 -Allyloxy-5-hexanolide, 6- (2-hydroxyethoxy) -5-hexanolide, 9-hydroxy-5-nonanolide, etc.), ethinomycin, iriflorental, iriparidal, 2'-8-C-glucosyl-7- Methyl aloesol coumaroyl ester, 2'-8-C -Glucosyl-7-methyl aloesol cinnamoyl ester, chloropyramine.

  Salicylic acid or salts thereof and derivatives thereof (salicylic acid glucoside, salicylic acid fatty acid ester, salicylic acid alcohol ether, salicylic acid amides, etc.), salicyl alcohol or salts thereof and derivatives thereof, apigenin, amentoflavone, ethylene oxide, ethylene glycol, diethylene glycol, Triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, propylene oxide, propylene glycol, 1,3-butylene glycol, pentyl glycol, glycerin, erythritol, pentaerythritol, dipentaerythritol , Threitol, arabitol, xylitol, ribitol Polyhydric alcohols such as galactitol, sorbitol, mannitol, lactitol, maltitol, cytilitol, laminitol, valienamine, valididamine, and validatol, glucose, galactose, mannose, xylose, fructose, maltose, isomaltose, cellobiose, gentiobiose, trehalose, cordobiose Laminaribiose, nigerose, cellobiose, sambubiose, neohesperidose, apiose, hamamelose, streptose, hydroxystreptose, dihydrostreptose, 2-methylerythrose or derivatives thereof, 2-methylerythronolactone, micalose, cladinose, Axenose, Alkanose, Olivomai Course, Chromose, Ebami Course, Vinerose, Noga Saccharides such as glucose, bilenose, nobiose, moenuronic acid, galosamine, cibirosamine, N-acyl kansosamine, vancosamine, eva nitrose, rubra nitrose, tetro nitrose, pyralose, α-octose, trioxacalcinose, aldogalose, blastminosin , Trehalose or derivatives thereof, D-mannosamine and derivatives thereof, primeverose or derivatives thereof.

  Sodium lactate, hydantoin and its derivatives, Np-vinylbenzyl-D-cellobionamide, Np-vinylbenzyl-D-lactone amide, Np-vinylbenzyl-D-maltonamide, Np-vinylbenzyl-D-gluconamide, glucosyl Oxyethyl methacrylate, galactosyloxypropyl acrylate, mannosyloxyethyl methacrylate, glutamyl lysine, glutaurine, 1,2,4-butanetriol, caran-3,4-diol, azoxaponin (3-o- [β-D-glucopyranosyl- β-D-glucuronopyranosyl] -sophoradiol, 3-o- [β-D-glucopyranosyl-3-D-glucuronopyranosyl] -soyasapogenol B, 3-o- [β-D- Glucopyranosyl-β-D-glucuronopyranosyl] -azuxapogenol, 3-o- [β-D-glucopyranosyl] -28-o- [β-D-glucopyranosyl-β-D-glucopyranosyl] -dip Sogenic acid, 3-o- [α-L-rhamnopyranosyl-β-D-glucopyranosyl-β-D-glucuronopyranosyl] -soya sapogenol B, 3-o- [β-D-glucopyranosyl-β- D-glucuronopyranosyl] -29-o- [β-D-glucopyranosyl-β-D-glucopyranosyl] -azuxapogenol and the like.

  Retinol or a salt thereof and a derivative thereof (retinyl unsaturated fatty acid ester such as retinyl linoleate, retinyl linolenate, retinyl oleate, and retinyl arachidonic acid), retinal or a salt thereof and a derivative thereof, dehydroretinal or a salt thereof and the like Derivatives thereof, retinoic acid or salts thereof and derivatives thereof, retinoic acid analogs (4-[[[8- (3,5-dimethylphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[ 8- (3-methylphenyl) -2-naphthalenyl) carbonyl] amino] benzoic acid, 4-[[[8- (4-methylphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[ 8- (2-methylphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[[8- (3,4-dimethylphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4- [ [[8- (2,4-dimethylphenol L) -2-Naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2-isopropylphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2-ethyl) Phenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2-fluorophenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2-methoxy Phenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[(8-benzyl-2-naphthalenyl) carbonyl] amino] benzoic acid, 4-[(E) -2- (8-phenyl-2-) Naphthalenyl) propenyl] benzoic acid), retinoic acid derivative (4-hydroxyphenylretinamide), retinoid analogue (4-[[(5,6-dihydro-5,5-dimethyl-8-ethyl-2-naphthalenyl) amino ] Carbonyl] benzoic acid, 4-[[(5,6-dihydro-5,5,8-trimethyl-2-naphthalenyl) amino] carbonyl] benzoic acid, 4-[[((5,6-dihydro-5,5 -Zimechi -8-phenyl-2-naphthalenyl) amino] carbonyl] benzoic acid, 4-[[((5,6-dihydro-5,5-dimethyl-8-ethyl-2-naphthalenyl) carbonyl] amino] benzoic acid, 4- [[(5,6-dihydro-5,5,8-trimethyl-2-naphthalenyl) -carbonyl] amino] benzoic acid, 4- (E)-[2- (5,6-dihydro-5,5-dimethyl -8-phenyl-2-naphthalenyl) -1-propenyl] benzoic acid, 4-[[(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl) oxy] carbonyl] benzoic acid, 4 -[[(5,6-dihydro-5,5-dimethyl-8-phenyl-2- (naphthalenyl) carbonyl] amino] benzoic acid, 4-[[((5,6-dihydro-5,5-dimethyl-8 -Phenyl-2- (naphthalenyl) carbonyl] oxy] benzoic acid, 4-[[5,6-dihydro-5,5-dimethyl-8- (2-fluorophenyl) -naphthalenyl] carbonyl] amino] benzoic acid, 4 -[[(5,6-Dihydro-5,5,6-trimethyl] -8-phenyl-2- (naphth Talenyl) carbonyl] amino] benzoic acid, 4-[[(5,6-dihydro-5,5,7-trimethyl-8-phenyl-2-naphthalenyl) carbonyl] benzoic acid, 4-[[((E)-( 5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] vinyl] benzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8-phenyl) -2 -Naphthalenyl] carbonyl] sulfamyl] benzoic acid, 4-[[[[(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl] sulfamyl] carbonyl] benzoic acid, 4-[[(5 6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] ethyl] benzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl ] Thiocarbonyl] amino] benzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] carbonyl] methyl] benzoic acid, 4-[[[((5 , 6-Dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] methyl] oxy] an Benzoic acid, 4-[[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthenyl] oxy] methyl] benzoic acid, 4-[[[((5,6-dihydro- 5,5-Dimethyl-8- (2,4-dimethylphenyl)]-2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[((5-6-dihydro-5,5-dimethyl-8- ( 4-methylphenyl)]-2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] ethyl] benzoic acid, 4 -[[[((5,6-Dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] sulfamyl] methyl] benzoic acid, 4-[[((5,6-dihydro-5,5-dimethyl- 8-Phenyl) -2-naphthalenyl] methyl] amino] benzoic acid, 4-[[[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] amino] thiocarbonyl] benzoic acid 4-[[[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] methyl] sulfamyl] benzoic acid, 4-[[[(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl] amino] methyl] benzoic acid, 4-[[[(5,6-dihydro-5,5-dimethyl -8-phenyl) -2-naphthalenyl] carbonyl] amino] -2-hydroxybenzoic acid, 4-[[[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] carbonyl] Amino] -2-nitrobenzoic acid, 4-[[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] carbonyl] amino] -2-fluorobenzoic acid, 4- [ [[(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl] carbonyl] amino] -2-methoxybenzoic acid, 4-[[[((5,6-dihydro-5,5- Dimethyl-8- (2-naphthalene)]-2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[((5,6-dihydro-8-phenyl-2-naphthalenyl) carbonyl] aminobenzoic acid, 4- [ [(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl) carbonyl] amino] -3- Luobenzoic acid, 4-[[(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl) carbonyl] amino] -3-methylbenzoic acid, 4-[[((5,8,10 , 10a-Tetrahydro-10,10-dimethyl-9-phenyl-2-anthracenyl) carbonyl] amino] benzoic acid, 4-[[((1,1-dimethyl-3-phenyl-1H1-inden-5-yl) amino ] Carbonyl] benzoic acid, 4-[(1,1-dimethyl-3-phenyl-1H-inden-5-yl-oxymethyl) benzoic acid, 4- [2- (1,1-dimethyl-3-phenyl-) 1H-Inden-5-yl) vinyl] benzoic acid, 4-[(1,1-dimethyl-3-phenyl-1H-indene-5-carbonyl) amino] benzoic acid).

  Carotene or a salt thereof and derivatives thereof (α-carotene, β-carotene, γ-carotene, lycopene, cryptoxanthine, lutein, zeaxanthin, isozeaxanthin, rhodoxanthine, capsanthin, crocetin and other carotenoids), lycopene or a salt thereof and the like Derivatives, thiamine or salts thereof and derivatives thereof (thiamine hydrochloride, thiamine disulfide, bisbenchamine, bisbutiamine, thiamine monophosphate disulfide, benfotiamine, chicotiamine, octothiamine, dicetiamine, fursultiamine, prosulfuramine Thiamine, astaxanthin thiamine phosphate diester, etc.), thiamine sulfate, riboflavin or its salts and derivatives thereof (flavin adenine dinucleotide, flavin mononucleotide, ribophine) Vinphosphate diester, 1-β-D-ribofuranosylnicotinamide pyrophosphate diester, 1-β-D-ribofuranosylnicotinic acid, etc.), pyridoxine or its salts and derivatives thereof (pyridoxine 3,4-dipalmitate) , 3,4-dicaprylic acid pyridoxine, pyridoxine sulfate diester, etc.), pyridoxal or a salt thereof and derivatives thereof, pyridoxamine or a salt thereof and derivatives thereof, cyanocobalamin or a salt thereof and derivatives thereof, cobalamines (methylcobalamin, adenosyl) Cobalamin, hydroxocobalamin, aquacobalamin etc.), folic acid or its salts and derivatives thereof, nicotinic acid or its salts and derivatives thereof, pantothenic acid or its salts and derivatives thereof, biotin or its salts and their derivatives, choline or Its salt and These derivatives, inositol, or salts thereof and derivatives thereof.

  Ergocalciferol or salts thereof and derivatives thereof, cholecalciferol and salts thereof and derivatives thereof (1α-hydroxy-22-[(1-hydroxy-1-methyl) -2-cyclopenten-4-yl-oxy]- 23,24,25,26,27-pentanorolecalciferol, [1R, 4R] -1α-hydroxy-22-[(1-hydroxy-1-methyl) -2-cyclopenten-4-yl-oxy]- 23,24,25,26,27-pentanorolecalciferol, [1R, 4S] -1α-hydroxy-22-[(1-hydroxy-1-methyl) -2-cyclopenten-4-yl-oxy]- 23,24,25,26,27-pentanorcorecalciferol, [1S, 4R] -1α-hydroxy-22-[(1-hydroxy-1-methyl) -2-cyclopenten-4-yl-oxy]- 23,24,25,26,27-pentanorcorecalciferol, [1S, 4S] -1α-hydroxy-22-[(1-hydroxy-1-methyl) -2-cyclopenten-4-yl-oxy]- 23, 24, 25, 26 27-pentanorcholecalciferol etc.), dihydrotaxosterol or a salt thereof and derivatives thereof, phytonadione or a salt thereof and derivatives thereof, menaquinone or a salt thereof and derivatives thereof, menadione or a salt thereof and derivatives thereof, menadiol or Salts thereof and derivatives thereof, carnitine or salts thereof and derivatives thereof, ferulic acid or salts thereof and derivatives thereof, γ-oryzanol or salts thereof and derivatives thereof, orotic acid or salts thereof and derivatives thereof, rutin or salts thereof Salts and derivatives thereof, eriocitrin or salts thereof and derivatives thereof, hesperidin or salts thereof and derivatives thereof, vitamin L group: anthranilic acid or salts thereof and derivatives thereof, adenylthiomethylpentose or salts thereof Their derivatives, methyl methionine sulfonium chloride or a derivative thereof.

  Valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid, hydroxylysine, arginine, ornithine, histidine Or derivatives thereof (N-octyloxycarbonyl-β-alanyl-L-histidine, N-dodecyloxycarbonyl-β-alanyl-L-histidine, N- (12-amino-1-oxododecyl) -L-histidine, N -2-Ethylhexyloxycarbonyl-β-alanyl-L-histidine hydrochloride, N-hexadecyloxycarbonyl-β-alanyl-L-histidine, N-octylaminocarbonyl-β-alanyl-L-histidine, N-dodecylamino Carbonyl-β-alanyl-L-histidine N-dodecylsulfonyl-β-alanyl-L-histidine, N-dodecylamino-oxalyl-β-alanyl-L-histidine, etc.) and their sulfates, phosphates, nitrates, citrates, or pyrrolidones Amino acids such as amino acid derivatives such as carboxylic acids, glycolic acid, citric acid, malic acid, tartaric acid, α-hydroxy acids such as lactic acid and succinic acid, 2-hydroxycarboxylic acids (methyllactic acid, 2-hydroxybutanoic acid, 2- Hydroxypentanoic acid, 2-hydroxyhexanoic acid, 2-hydroxyheptanoic acid, 2-hydroxyoctanoic acid, 2-hydroxynonanoic acid, 2-hydroxydecanoic acid, 2-hydroxyundecanoic acid, α-hydroxylauric acid, α-hydroxymyristine Acid, α-hydroxypalmitic acid, α-hydroxystearic acid, α-hydroxyarachidonic acid, cerebronic acid, α-hydroxyne Boronic acid, mandelic acid, benzylic acid, phenyllactic acid, atrolactic acid, 2- (4'-hydroxyphenyl) -2-hydroxyethanoic acid, 2- (4'-chlorophenyl) -2-hydroxyethanoic acid, 2- (3 '-Hydroxy-4'-methoxyphenyl) -2-hydroxyethanoic acid, 2- (4'-hydroxy-3'-methoxyphenyl) -2-hydroxyethanoic acid, 3- (2'-hydroxyphenyl) -2- Hydroxypropanoic acid, 3- (4'-hydroxyphenyl) -2-hydroxypropanoic acid, 2- (3 ', 4'-dihydroxyphenyl) -2-hydroxyethanoic acid, glyceric acid, erythronic acid, ribbon acid, arabinonic acid , Xylonic acid, lyxonic acid, aronic acid, altronic acid, gluconic acid, mannonic acid, gulonic acid, idonic acid, galactonic acid, taronic acid, glucoheptonic acid, galactoheptonic acid, tartronic acid, mucinic acid, etc.), polyhydroxycarboxylic Or hydroxypolycarboxylic acids (gluconolactone, galactonolactone, glucuronolactone, galacturonolactone, gulonolactone, ribonolactone, sugar lactone, pantoyl lactone, glucoheptonolactone, mannonolactone, galactoheptonolactone, etc.) 2-keto acids (glyoxylic acid, methyl 2-ketoethanoate, benzoylformate, methyl benzoylformate, ethyl benzoylformate, phenylpyruvic acid, methyl phenylpyruvate, ethyl phenylpyruvate, 2-ketobutanoic acid, 2-ketopentanoic acid, 2-ketohexanoic acid, 2-ketoheptanoic acid, 2-ketooctanoic acid, 2-ketododecanoic acid, methyl 2-ketooctanoate, etc.), quinic acid, isocitric acid, tropic acid, tretocanic acid, 3-chlorolactic acid, cerebronic acid, citramalic acid , Agaricic acid, alloy Acid, pantoic acid, lactobionic acid, hexulosonic acid, photosensitizer 301, allantoin, pentadecanoic acid glyceride, estradiol, etenyl estradiol, antialol or its glycoside, lionilecinol or its glycoside, rhododendrol or its coordination Glycosides, platifironol or glycosides thereof.

  Lactone compounds (D-glucurono-6,3-lactone, α-D-glucoheptonic-γ-lactone, δ-glucuronolactone, α, β-glucooctonic-γ-lactone, L-glonic-γ-lactone , Γ-D-galactonolactone, D-saccharide-1,4-lactone, D-saccharide-3,6-lactone, D-ribonic-γ-lactone, α-butyrolactone, γ-butyrolactone, α-octanoic Lactone, γ-octanoic lactone, nonanoic lactone, γ-valerolactone, D-manninoic-δ-lactone, D-xyleuic-δ-lactone, D-arabinoic-δ-lactone, stearoyl-δ-gluconolactone, DL-pantolactone, palmitoyl-DL-pantolactone, etc.), 3-hydroxy-3,4-dicarboxy-1,4-butanolide or derivatives thereof, 6-benzylaminopurine or derivatives thereof, 1,4-diazadicyclo Kutan, 2,5-dimethylfuran, 2-methylfuran, 2,5-diphenylfuran, 1,3-diphenylisobenzofuran, rutin, tectrigenin 7-xylosyl glucoside, captopril, alacepril, lisinopril, enalapril, delapril, benazepril , Cilazapril, Imidapril, Quinapril, Trendapril, Perindopril, Temocapril, Losartan, Endothelin, Galactomannan saccharide polymer, Mucin, Trimethylglycine, Proteoglycan, Lactic acid bacteria extract, Lactic acid bacteria culture extract, Lactic acid bacteria fermented milk extract, Bifidobacteria extract, Bifidobacteria Culture fluid extract, bifidobacteria fermented milk extract, placenta extract, ganoderma extract, spleen extract, thymus extract, yeast extract, yeast culture fluid extract, yeast fermentation extract, filamentous fungus extract, filamentous fungus Nutrient solution extract, Basidiomycetes extract, basidiomycetes culture extract, bacterial cell disruption extract, bacterial culture extract, cultured human dermal cell rupture extract.

  Benzochroman derivatives, nordihydrogua ceretenoic acid, butylhydroxytoluene (BHT), butylhydroxyanisole (BHA), hydroxytyrosol, parahydroxyanisole, propyl gallate, sesamol, sesamolin, gossypol, maritimaine, sulfretin, xanthene-2, 7-diols, caffeoylquinic acids, propolis, carotenoids (α-carotene, β-carotene, γ-carotene, lycopene, lutein, violaxanthin, spiroloxanthine, spheroidene, astaxanthin, etc.), phlorotannins, superoxide dismutase Catalase, glutathione peroxidase, bilirubin, quercetin, quercitrin, catechin, catechin derivatives, rutin or derivatives thereof, gallic acid or salts thereof and derivatives thereof, Curcumin or a salt thereof and derivatives thereof, transferrin, ceruloplasmin, coenzyme Qn (n = 7 to 10), uric acid, bilirubin, metallothionein, stilbengaloyl glycoside (3,5,4′-trihydroxystilbene 4′- o-β-D- (6 "galloyl) glucopyranoside, 3,5,4'-trihydroxystilbene 4'-o-β-D- (2" galloyl) glucopyranoside, etc.), chlorogenic acid phospholipid ester, sphingosine chlorogenic acid Esters and derivatives thereof, chlorogenic acid glycolipid esters, chlorogenic acid sugar esters, chlorogenic acid sterol esters, thiazole derivatives or salts thereof (2- (3,4-diethoxyphenyl) -4- (3-carboxy-4-hydroxyphenyl) ) Thiazole, 2- (3,4-diethoxyphenyl) -4- [3-carboxy-4-hydroxy-5- (2-methyl-2-propenyl) phenyl] thiazole and 2- (3,4-diethoxyphenyl) -4- (3-carboxy-4-hydroxy-5-methylphenyl) thiazole, 2- (3,4-diethoxyphenyl) -4- (3-carboxy-5-methoxy Phenyl) thiazole,), hydroxymatylesinol, allohydroxymatylesinol, hydantoin derivatives.

  Phthalazine derivatives (4-ethyl-1- (β-hydroxyethylamino) phthalazine, 4-N-propyl-1- (β-hydroxyethylamino) phthalazine, 4-N-butyl-1- (β-hydroxyethylamino) Phthalazine, 4-N-butyl-1- (β-hydroxypropylamino) phthalazine, etc.), xanthine derivatives (caffeine, theophylline, theobromine, xanthine, aminophylline, choline theophylline, diprofylline, proxyphylline, oxtriphyrin, etc.), benzophenone Derivatives (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid, sodium 2-hydroxy-4-methoxybenzophenone-5-sulfonate, dihydroxydimethoxybenzophenone, dihydroxydimethoxybenzophenone-sulfonic acid Sodium, 2,4-dihydroxybenzo Phenone, tetrahydroxybenzophenone, etc.), 1,2-dihydroxy-4- (2-hydroxyethyl) benzene derivative (1- (2- (4- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) ethyl -3-hydroxy-4-methoxybenzene, 1- (2- (6- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) ethyl-3-hydroxy-4-methoxybenzene, 1- (2- (2-acetyl-4- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- (2-acetyl-6- (3,4-dihydroxy) Cinnamoyl) -3-rhamnosyl) glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- (4- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) ethyl-3,4-dihydroxy Benzene, 1- (2- (6- (4-hydroxy-3-methoxycinnamoyl) -3-rhamnosyl) glucosyl) ethyl-3,4-dihydroxy Cybenzene, 1- (2- (4- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) -1-methoxyethyl-3,4-dihydroxybenzene, 1- (2- (4- (3, 4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) -1-hydroxyethyl-3,4-dihydroxybenzene, 1- (2- (6- (3,4-dihydroxycinnamoyl) -3-xylosyl) glucosyl) Ethyl-3,4-dihydroxybenzene, 1- (2- (3-arosyl-6- (3-hydroxy-4-methoxycinnamoyl)) glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- ( 3-glucosyl-6- (3-hydroxy-4-methoxycinnamoyl)) glucosyl) ethyl-3-hydroxy-4-methoxybenzene, 1- (2- (3-allosyl-6- (3-hydroxy-4-) Methoxycinnamoyl) glucosyl) ethyl-3-hydroxy-4-methoxybenzene, 1- (2- (4- (3,4-dihydroxycinnamoyl) glucosyl) ethyl) -3,4-dihydro Cybenzene, 1- (2- (3- (3,4-dihydroxycinnamoyl) glucosyl) ethyl) -3,4-dihydroxybenzene, 1- (2- (2- (3- (4-dihydroxycinnamoyl) glucosyl) Ethyl) -3,4-dihydroxybenzene, 1- (2- (6- (3,4-dihydroxycinnamoyl) glucosyl) ethyl) -3,4-dihydroxybenzene, etc.).

  Paraaminobenzoic acid derivatives (paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, amyl paradimethylaminobenzoate, octyl paradimethylaminobenzoate, etc.), methoxycinnamate derivatives (ethyl paramethoxycinnamate, isopropyl paramethoxycinnamate, Octyl paramethoxycinnamate, 2-ethoxyethyl paramethoxycinnamate, sodium paramethoxycinnamate, potassium paramethoxycinnamate, glyceryl mono-2-ethylcinnamate mono-2-ethylhexanoate), anthranilic acid derivatives (such as methyl anthranilate), urocanic acid derivatives (Urocanic acid, ethyl urocanate, etc.), coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, Camphor derivatives, furan derivatives, pyrone derivatives, nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives, pyridoxine derivatives, pyridoxal derivatives, pyridoxamine derivatives, amethoflavone, neosacranin, 6-dehydrocavine, triazine derivatives (4,4'4 "-(1 , 3,5-triazine-2,4,6-triyltriimino) trisbenzoic acid tris-2-ethylhexyl, etc.), phosphatidyl chromanol derivatives (1,2-dilauryl glycero-3-phospho-2'-hydroxy Methyl-2 ′, 5 ′, 7 ′, 8′-tetramethyl-6′-hydroxychroman, 1,2-dimyristoylglycero-3-phospho-2′-hydroxymethyl-2 ′, 5 ′, 7 ′, 8'-tetramethyl-6'-hydroxychroman, 1,2-dipalmitoylglycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxy Chroman, 1,2-distearoylglycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1,2-diarachidonylglycero- 3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1-myristoyl-2-palmitoylglycero-3-phospho-2'-hydroxymethyl- 2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1-myristoyl-2-stearoylglycero-3-phospho-2'-hydroxymethyl-2', 5 ', 7', 8 '-Tetramethyl-6'-hydroxychroman, 1-palmitoyl-2-myristoylglycero-3-phospho-2'-hydroxymethyl-2', 5 ', 7', 8'-tetramethyl-6'-hydroxychroman 1-palmitoyl-2-stearoylglycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetra Til-6′-hydroxychroman, 1-stearoyl-2-myristoylglycero-3-phospho-2′-hydroxymethyl-2 ′, 5 ′, 7 ′, 8′-tetramethyl-6′-hydroxychroman, 1- Stearoyl-2-palmitoylglycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman), L-carnosine zinc complex, umbelliferone, Esculin, benzyl cinnamate, cinoxalate, oxybenzone, dioxybenzone, octabenzone, thorisobenzone, benzoresorcinol, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, neoheliopan, chlorophylls, xanthophylls, escalol, zinc oxide, talc, kaolin .

  Zinc sulfate, zinc oxide, calamine, zinc p-phenolsulfonate, potassium aluminum sulfate, resorcin, ferric chloride, tannins (tannic acid, hamamelitannin, acertannin, tetragalloyl glucose, pentagalloyl glucose, hexa Gallotannins such as galloyl glucose, heptagalloyl glucose, octagalloyl glucose, nonagaroyl glucose, decagalloyl glucose, undecagalloyl glucose, dodecagalloyl glucose, Elazitannins such as peduncragin, geraniin, isotarkebin, granatin A, granatin B, ketulinic acid, kebraguic acid, casuarine, nuphalin, procyanidin B-2, thiacinensin A, thiacinensin B ), Quinolinone derivatives, dibenzooxepin derivatives, thiotroposin, phthalimide derivatives, flurbiprofen, felbinac, bufexamac, suprofen, 1,4-diphenylpropylpiperazine derivatives, carxin compounds, chromanol glycosides (2- (α- D-glucopyranosyl) methyl-2,5,7,8-tetramethylchroman-6-ol), ictamol, indomethacin, kaolin, diphenhydramine hydrochloride, d-camphor, DL-camphor, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid , Hydrocortisone, guaiazulene, camazulene, chlorpheniramine maleate, diphenhydramine hydrochloride, clemastine fumarate, cyproheptadine hydrochloride, promethazine hydrochloride, piperazine derivatives, α-D-phenylglycoside derivatives.

  Glycyrrhizic acid or a salt thereof and derivatives thereof (α-glycyrrhizic acid, β-glycyrrhizic acid, α-glycyrrhizic acid methyl ester, β-glycyrrhizic acid methyl ester, α-glycyrrhizinate trisodium, α-glycyrrhizinate monopotassium Dipotassium glycyrrhizinate, monoammonium α-glycyrrhizinate, trisodium β-glycyrrhizinate, monopotassium β-glycyrrhizinate, dipotassium β-glycyrrhizinate, monoammonium β-glycyrrhizinate), glycyrrhetinic acid or its salts and derivatives thereof ( α-glycyrrhetinic acid, β-glycyrrhetinic acid, α-glycyrrhetinic acid stearyl, β-glycyrrhetinic acid stearyl, α-glycyrrhetinic acid pyridoxine, β-glycyrrhetinic acid pyridoxine, α-glycyrrhetinic acid glycerin, β-glycylretinoic acid Glyceryl tyrretate, disodium 3-succinyloxyglycyrrhetinate, etc.), mefenamic acid, phenylbutazone, ibuprofen, ketoprofen, allantoin, pantothenic acid calcium, pantothenyl ethyl ether and the like panthenol or salts thereof and derivatives thereof, ε- Aminocaproic acid, diclofenac sodium, tranexamic acid or derivatives thereof (trans-4-benzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4-p-nitrobenzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4-p-chlorobenzyloxy Carbonylaminomethylcyclohexanecarboxylic acid, trans-4-p-bromobenzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4-m-chlorobenzyloxy Carbonylaminomethylcyclohexanecarboxylic acid, trans-4-p-methoxybenzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4-p-methylbenzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4-benzyloxycarbonylaminomethylcyclohexanecarboxylic acid Acid sodium, ammonium trans-4-p-nitrobenzyloxycarbonylaminomethylcyclohexanecarboxylate, potassium trans-4-p-chlorobenzyloxycarbonylaminomethylcyclohexanecarboxylate, trans-4-p-bromobenzyloxycarbonylaminomethylcyclohexane Potassium carboxylate, trans-4-m-chlorobenzyloxycarbonylaminomethylcyclohexanecarboxylate calcium, trans-4-p-methoxy Magnesium benzyloxycarbonylaminomethylcyclohexanecarboxylate, trans-4-p-methylbenzyloxycarbonylaminomethylcyclohexanecarboxylic acid monoethanolamine, trans-4-t-butyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4- ( 2-Phenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (p-biphenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (3,5-dimethoxyphenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid Acid, trans-4- (p-methylphenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4-t-butyloxycarbonylaminomethylcyclohexyl Sodium suncarboxylate, potassium trans-4- (2-phenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylate, calcium trans-4- (p-biphenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylate, trans-4- (3, 5-Dimethoxyphenylisopropyloxycarbonylaminomethyl) magnesium cyclohexanecarboxylate, trans-4- (p-methylphenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid monoethanolamine, trans-4- (9-fluorenylmethyloxycarbonyl) Aminomethyl) cyclohexanecarboxylic acid, trans-4-methylsulfonylethyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4- (9-fluorenylmethyloxycarbonylamino) Til) sodium cyclohexanecarboxylate, potassium trans-4-methylsulfonylethyloxycarbonylaminomethylcyclohexanecarboxylate, trans-4- (pyridine-4'-methyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (2, 2,2-trichloroethyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (2-trimethylsilylethoxycarbonylaminomethyl) cyclohexanecarboxylate potassium, trans-4- (pyridine-4'-methyloxycarbonylaminomethyl) cyclohexane Sodium carboxylate, trans-4- (2,2,2-trichloroethyloxycarbonylaminomethyl) cyclohexanecarboxylate potassium, trans-4- (2-trimethylsilylethoxycarbonylaminomethyl) cyclohexane Calcium phosphate, etc.), sulfatide.

  Astaxanthin fatty acid diester (astaxanthin dilaurate, astaxanthin dimyristate, astaxanthin dipentadecanoate, astaxanthin dipalmitate, astaxanthin dipalmitoleate, astaxanthin diheptadecanoate, astaxanthin dielaidate, astaxanthin Diricinoleic acid ester, astaxanthin petrothelinic acid ester, astaxanthin vaccenic acid ester, astaxanthin eleostearic acid ester, astaxanthin punicic acid ester, astaxanthin licanoic acid ester, astaxanthin parinaric acid ester, astaxanthin gadoric acid ester, astaxanthin 5-eicosene Acid ester Taxanthin 5-docosenoic acid ester, astaxanthin cetolic acid ester, astaxanthin erucic acid ester, astaxanthin 5,13-docosadienoic acid ester, astaxanthin ceracholic acid ester, astaxanthin desenic acid ester, astaxanthin steric acid ester, astaxanthin dodecenoic acid ester, astaxanthin Dioleic acid ester, astaxanthin distearic acid ester, astaxanthin dieicosapentaenoic acid ester, astaxanthin didocosahexaenoic acid ester, astaxanthin dilinolenic acid ester, astaxanthin dilinolenic acid ester, astaxanthin diarachidonic acid ester, etc.), astaxanthin diglycerophosphate (astaxanthin) Diglycerophosphate Ter, astaxanthing lyserophosphate palmitic acid, astaxanthing lyserophosphatidylcholine palmitic acid, astaxanthing lyserophosphatidylcholine DHA, astaxanthing lyserophosphatidylinositol palmitic acid, astaxanthing lyserophosphatidylinositol DHA, astaxanthing lysinophosphatidyl oleositol , Astaxanthin lyserophosphatidylcholine linoleic acid, etc.), steviol glycosides, benzimidazole derivatives (1- (2-ethoxyethyl) -2- [1- (2- (4- (1- (4,4-dimethyl -2-oxazolin-2-yl) -1-methylethyl) phenyl) ethyl) piperidin-4-yl] -1H-benzimidazole, 2- [4- (2- (4- (1- (2-ethoxyethyl) ) Benzimidazol-2-yl) piperidin-1-yl) ethyl) phenyl] -2- Methylpropanoic acid, ethyl 2- [4- (2- (4- (1- (2-ethoxyethyl) benzimidazol-2-yl) piperidin-1-yl) ethyl) phenyl] -2-methylpropanoate, 1 -(2-ethoxyethyl) -2- [1- (2- (4- (1,1-dimethyl-2-hydroxyethyl) phenyl) ethyl) piperidin-4-yl] -1H-benzimidazole, 1- ( 2-hydroxyethyl) -2- [1- (2- (4- (1- (4,4-dimethyl-oxazolin-2-yl) -1-methylethyl) phenyl) ethyl) piperidin-4-yl]- 1H-benzimidazole, 2- [4- (2- (4- (1- (2-hydroxyethyl) benzoimidazol-2-yl) piperidin-1-yl) ethyl) phenyl] -2-methylpropanoic acid, etc.) An alanine derivative or a salt thereof (N- {3-isopentyl-4-methyl-2- [4- (3-trifluoromethylbenzamido) benzoylimino] -3H-thiazoline-5-carbonyl} -L-alanine, N- {3-Isopentyl-4-methyl-2- [4- (3-trifluoromethyl Rubenzamido) benzoylimino] -3H-thiazoline-5-carbonyl} -2-methylalanine, N- {3-isopentyl-4-methyl-2- [4- (3-trifluoromethylbenzamido) benzoylimino] -3H -Thiazoline-5-carbonyl} -N-methyl-L-alanine), thiazoline derivatives or salts thereof (3-isopentyl-4-methyl-2- [4- (3-trifluoromethylbenzamido) benzoylimino] -3H -Thiazoline-5-carboxylic acid, 4-isobutyl-3-methyl-2- [4- (3-trifluoromethylbenzamido) benzoylimino] -3H-thiazoline-5-carboxylic acid, etc.), chlorpheniramine maleate, Diphenhydramine hydrochloride, diphenylpyraline hydrochloride, carbinoxamine maleate, hydrocortisone butyrate, sulfated acid mucopolysaccharide or salt thereof, sulfated dextran or salt thereof.

  Chroman derivatives, pyridoxine or a salt thereof and derivatives thereof, pyridoxal or a salt thereof and derivatives thereof, pyridoxamine or a salt thereof and derivatives thereof, sulfur, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or a hydrolyzate thereof , Alkyldiaminoethylglycine chloride solution, triclosan, sodium hypochlorite, chloramine T, salicin powder, iodine compound, iodoform, 1-alkylcarbapenem compound, N-substituted azepane derivative or salt thereof, sorbic acid or salt thereof, propion Acid or salt thereof, salicylic acid or salt thereof, dehydroacetic acid, parahydroxybenzoic acid esters, 2-keto-3-deoxyoctanoic acid fatty acid ester, inositol deoxy derivative (quercitol, etc.) ), Inositol unsaturated derivatives (such as chonditol), inositol dimethyl ether, methyl inositol, inositol methyl ether, inosamine, deoxyinosadiamine, shikimic acid, quinic acid, undecylenic acid, thiamine lauryl sulfate, thiamine lauryl nitrate, phenol, cresol, p -Chlorophenol, p-chloro-m-xylenol, p-chloro-m-cresol, thymol, phenethyl alcohol, o-phenylphenol, Irgasan CH3565, halocarban, hexachlorophene, chlorohexidine, ethanol, methanol, isopropyl alcohol, benzyl alcohol , Ethylene glycol, propylene glycol, 2-phenoxyethanol, 1,2-pentanediol, zinc pyridione, chlorobutanol, isopropylmethylpheno , Elemol, vetiverol, patchouli alcohol, nonionic surfactant (polyoxyethylene lauryl ether, polyoxyethylene nonylphenyl ether, polyoxyethylene octylphenyl ether, etc.), amphoteric surfactant, anionic surfactant (lauryl sulfate) Sodium, lauroyl sarcosine potassium, etc.), cationic surfactants (cetyltrimethylammonium bromide, benzalkonium chloride, benzethonium chloride, methylrosaniline chloride), formaldehyde, hexamine, brilliant green, malachite green, crystal violet, germal, photosensitizer 101 Photosensitive element 201, photosensitive element 401, N-long chain acyl basic amino acid derivatives and acid addition salts thereof.

  Cephalanthin, carpronium chloride, eugenol derivatives (acetyleugenol, methyleugenol, methylisoeugenol, ethylisoeugenol, ethylisoeugenol, salicylic acid eugenol, etc.), minoxidil, red pepper tincture, nonylic acid vanillamide, cantalis tincture, pepper tincture, peppermint oil, L-menthol, camphor, benzyl nicotinate, cinnarizine, trazoline, acetylcholine, verapamil, ictamol, α-borneol, cyclandelate, nonyl acid valenylamide, capsaicin, gingerone, follicular hormone (estrone, estradiol, ethinyl estradiol, etc.), isoflavone, Oxendron, 4 ', 5,7-trihydroxy-8-prenylflavanone, 4', 5,7-trihydroxy-8-preni Flavone, 3,3 ′, 4 ′, 5,7-pentahydroxy-8-prenylflavone, nicorandil, cyclosporic acid, carbostyril derivative or salt thereof, dicarboxylic acid (glutaric acid, adipic acid, pimelic acid, suberic acid , Azelaic acid, sebacic acid, 1,9-nonamethylenedicarboxylic acid, 1,10-decamethylenedicarboxylic acid), rosmarinic acid, ursolic acid, oleanolic acid, hydroxamic acid derivative, esculetin derivative.

  Anthocyanidins, nordihydroguaiaretech acid, 20-carboxy-16-hydroxy-21-nor-5 alpha-7,9 (11) -lanostadien-3,24-dione, ubiquinone, plataquinone, yuglone, shikonin, quinizarin , Alizarin, abietin, levopimar, betulin, α-amylin, catechin compounds (catechin, epigallocaequine, epigallocatechin gallate, epicatechin, epicatechin gallate, catechin rhamnopyranoside catechin, etc.), diisopropyl fluorophosphate, (2R, 6R) -2,6-Dihydroxy-4- (tert-butyldimethylsilyloxy)-(3Z) -heptene-1,7-dicarboxylate, N, N'-bis [(1S, 2R) -2-hydroxy Indan-1-yl]-(2R, 6R) -2,6-dibenzyloxy-4-hydroxyheptanedicarboxylic acid-1,7-diamide, (2R, 6R) -2,6-dihydroxy-4- (tert -Butyl dimethyl (Tylsilyloxy) heptane-1,7-dicarboxylate, (2R, 6R) -2,6-dibenzyloxy-4- (tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylate, (2R , 6R) -2,6-Dibenzyloxy-4- (tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylic acid, N, N′-bis [(1S, 2R) -2-hydroxyindan-1 -Yl]-(2R, 6R) -2,6-dibenzyloxy-4- (tert-butyldimethylsilyl) oxyheptane-1,7-dicarboxylic acid diamide, N, N′-bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2R, 6R) -2,6-dibenzyloxy-4-hydroxyheptane-1,7-dicarboxylic acid diamide, N, N′-bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2R, 6R) -2,4,6-trihydroxyheptane-1,7-dicarboxylic acid diamide, N, N′-bis [(1S, 2R) -2- Hydroxyindan-1-yl]-(2S, 6S) -2,6-dibenzyloxy-4- Droxyheptane-1,7-dicarboxylic acid diamide, (2S, 6S) -2,6-dihydroxy-4- (tert-butyldimethylsilyloxy)-(3Z) -heptene-1,7-dicarboxylic acid dimethyl, ( 2S, 6S) -2,6-Dihydroxy-4- (tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylate, (2S, 6S) -2,6-dibenzyloxy-4- (tert- Butyldimethylsilyloxy) heptane-1,7-dicarboxylate, (2S, 6S) -2,6-dibenzyloxy-4- (tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylic acid, N, N′-bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2S, 6S) -2,6-dibenzyloxy-4- (tert-butyldimethylsilyl) oxyheptane-1,7 -Dicarboxylic acid diamide, N, N'-bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2R, 6R) -2,6-dibenzyloxy-4-hydroxyheptane-1,7 -Dicarboxylic acid diamide, 3-[[4- (4-Fluorophenoxy) -benzenesulfonyl]-(1-hydroxycarbamoylcyclopentyl) -amino] -propionic acid, 4- [4- (4-fluorophenoxy) -benzenesulfonylamino] -tetrahydropyran-4-carboxylate hydroxy Amido, 4- [4- (4-Chlorophenoxy) -benzenesulfonylmethyl] -tetrahydropyran-4-carboxylic acid hydroxyamide, 3-[[4- (4-Fluorophenoxy) -benzenesulfonyl]-(1-hydroxy Carbamoylcyclobutyl) -amino] -propionic acid, 4- (4′-chlorobiphenyl-4-yl) -2- [2- (1,3-dioxo-1,3-dihydroisoindol-2-yl)- Ethyl] -4-oxobutyric acid, {1- [4- (4-fluorobenzyloxy) -benzenesulfonyl] -2-hydroxycarbamoylpiperidin-3-yl) -carbamic acid isopropyl ester, 2- [4- (4- Fluorophenoxy) -benzenesulfonyl Mino] -N-hydroxy-2-methylfuropionamide, 3- [4- (4-fluorophenoxy) -benzenesulfonyl] -2, N-dihydroxyfuropionamide, 3- (4-phenoxybenzenesulfonyl) -7 -Oxabicyclo [2.2.1] heptane-2-carboxylic acid hydroxyamide, (4-benzylbenzyl)-[2- (2,2-dimethyl-1-methylcarbamoylpropylcarbamoyl) -4- (4'-fluorobiphenyl) -4-yl) -butyl] -phosphinic acid, 2-amino-3- [4- (4-fluorophenoxy) -benzenesulfonyl] -N-hydroxypropionamide, and N-hydroxy-2- (4-phenylpiperidine -1-sulfonyl) -acetamide.

  Ethanolamine derivatives, pentoxyphyllin, serine derivatives, geraniol, crocetin, methyl 4- (2-ethylhexyloxy) -2-hydroxybenzoate, 2-hydroxy-4- (3,5,5-trimethylhexyloxy) benzoic acid Methyl, methyl 4-cyclohexylmethoxy-2-hydroxybenzoate, methyl 4- (2-cyclohexylethoxy) -2-hydroxybenzoate, 4- (3,7-dimethyl-6-octenyloxy) -2-hydroxybenzoate Acid methyl, ethyl 3- (2-ethylhexyloxy) -5-hydroxybenzoate, methyl 5- (2-ethylhexyloxy) -2-hydroxybenzoate, 2-hydroxy-5- (3,5,5-trimethylhexyl Methyl oxy) benzoate, methyl 5- (2-cyclohexylethoxy) -2-hydroxybenzoate, methyl 4-N-hexyloxy-2-hydroxybenzoate, 2-hydroxy-4-N-octyloxybenzoic acid Chill, methyl 4-N-decyloxy-2-hydroxybenzoate, methyl 5-N-hexyloxy-2-hydroxybenzoate, 4- (2-ethylhexyloxy) -2-hydroxybenzoic acid, 2-hydroxy-4- (2,5,5-trimethylhexyloxy) benzoic acid, 4-cyclohexylmethoxy-2-hydroxybenzoic acid, 4- (2-cyclohexylethoxy) -2-hydroxybenzoic acid, 4- (3,7-dimethyl-6 -Octenyloxy) -2-hydroxybenzoic acid, 3- (2-ethylhexyloxy) -5-hydroxybenzoic acid, 5- (2-ethylhexyloxy) -2-hydroxybenzoic acid, 5- (2-ethylhexyloxy) 2-hydroxybenzoic acid, 2-hydroxy-5- (3,5,5-trimethylhexyloxy) benzoic acid, 5- (2-cyclohexylethoxy) -2-hydroxybenzoic acid, 4-N-hexyloxy-2 -Hydroxybenzoic acid, 5-N-hexyloxy-2-hydroxybenzoic acid, 2-H Roxy-4-N-octyloxybenzoic acid, 4-N-decyloxy-2-hydroxybenzoic acid, N- (2-hydroxyethyl) -4- (2-ethylhexyloxy) -2-hydroxybenzamide, N-ethyl- 4- (2-ethylhexyloxy) -2-hydroxybenzamide, 2-acetoxy-4-cyclohexylmethoxybenzoic acid, sodium 4- (2-ethylhexyloxy) -2-hydroxybenzoate, 4-{(2E) -3, Methyl 7-dimethyl-2,6-octadienyloxy} -2-hydroxybenzoate, ethyl 4-{(2E) -3,7-dimethyl-2,6-octadienyloxy} -2-hydroxybenzoate , 5-{(2E) -3,7dimethyl-2,6-octadienyloxy} -2-hydroxybenzoate, 3-{(2E) -3,7-dimethyl-2,6-octadienyl Ethyl oxy} -2-hydroxybenzoate, ethyl 3-{(2E) -3,7-dimethyl-2,6-octadienyloxy} -5-hydroxybenzoate, 4-{(2E) -3,7-dimethyl-2,6-octadienyloxy} -3-methoxybenzoate, 4-{(2E, 6E) -3,7,11-trimethyl-2,6 , 10-dodecatrienyloxy} -2-hydroxybenzoic acid methyl, 4-{(2E) -3,7-dimethyl-2,6-octadienyloxy} -2-hydroxybenzoic acid (2E) -3, 7-dimethyl-2,6-octadienyl, 4-{(2E) -3,7-dimethyl-2,6-octadienyloxy} -2-hydroxybenzoic acid, 5-{(2E) -3,7- Dimethyl-2,6-octadienyloxy} -2-hydroxybenzoic acid, 3-{(2E) -3,7-dimethyl-2,6-octadienyloxy} -2-hydroxybenzoic acid, 3- { (2E) -3,7-dimethyl-2,6-octadienyloxy} -5-hydroxybenzoic acid, 2-hydroxy-4-{(2E, 6E) -3,7,11-trimethyl-2,6 , 10-dodecatrienyloxy} benzoic acid, 4-{(2E) -3,7-dimethyl-2,6-octadienyloxy} -3-methoxy Benzoic acid, 2-acetoxy-4-{(2E) -3,7-dimethyl-2,6-octadienyloxy} benzoic acid, N- (2-hydroxyethyl) -4-{(2E) -3, 7-dimethyl-2,6-octadienyloxy} -2-hydroxybenzamide, 4-{(2E) -3,7-dimethyl-2,6-octadienylamino} -2-hydroxybenzoic acid, dimethyl- 2,6-octadienyloxy} benzoic acid, N- (2-hydroxyethyl) -4-{(2E) -3,7-dimethyl-2,6-octadienyloxy} -2-hydroxybenzamide, 4 -{(2E) -3,7-dimethyl-2,6-octadienylamino} -2-hydroxybenzoic acid, 3-dodecyloxybenzoic acid, 3- (12-hydroxydodecyloxy) benzoic acid, 4-dodecyl Oxybenzoic acid, 4- (12-hydroxydodecyloxy) benzoic acid, 3- (12-hydroxyoctadecyloxy) benzoic acid, 4- (12-hydroxyoctadecyloxy) benzoic acid, 3- (11-hydroxy Cyundecyloxy) benzoic acid, 4- (11-hydroxyundecyloxy) benzoic acid, 3-[(2E) -3,7-dimethyl-2,6-octadienyloxy] benzoic acid, 4-[(2E ) -3,7-dimethyl-2,6-octadienyloxy] benzoic acid, 3-[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] benzoic acid 4-[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] benzoic acid, 4- [3,7-dimethyl-9- (2,6,6- Trimethyl-1-cyclohexen-1-yl) -2,4,6,8-nonatetraenyloxy] benzoic acid, 4- [3,4-dihydro-2,5,7,8-tetramethyl-2- ( 4,8,12-Trimethyltridecyl) -2H-1-benzopyran-6-oxy] benzoic acid, 4-[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyl Oxy] benzamide, 4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] benzamide, 4- (2-methyl-2-butenyloxy) benz Amides, 4- (2-ethylhexyloxy) benzamide, 4-dodecyloxybenzamide, 4- (12-hydroxydodecyloxy) benzamide, 4- (12-hydroxyoctadecyloxy) benzamide, 4- (11-hydroxyundecyloxy) Benzamide, 4- (10-hydroxydecyloxy) benzamide, 4-isostearyloxybenzamide, N- (2-hydroxyethyl) -4-[(2E, 6E) -3,7,11-trimethyl-2,6, 10-dodecatrienyloxy] benzamide, N, N-dimethyl-4-[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] benzamide, N, N-di [(2E) -3,7-dimethyl-2,6-octadienyl] -4-aminobenzamide, 4- [N'-methoxycarbonyl-N-[(2E) -3,7-dimethyl-2,6-octa Dienylamino] benzamide, 4- [N-acetyl-N-[(2E) -3,7-dimethyl-2,6-octadienyl]] aminobenz Mido, N- (2-hydroxyethyl) -4-[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] -2-hydroxybenzamide, N, N-diethyl -4-[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] -2-hydroxybenzamide.

  Anacardic acid or derivatives thereof (6-pentadecatrienylsalicylic acid methyl ether, 6-pentadecatrienylsalicylic acid ethyl ether, 6-pentadecatrienylsalicylic acid propyl ether, 6-pentadecatrienylsalicylic acid butyl ether, 6-pentadecatrienylsalicylic acid butyl ether, Enyl salicyl alcohol methyl ether, 6-pentadecatrienyl salicyl alcohol ethyl ether, 6-pentadecatrienyl salicyl alcohol propyl ether, 6-pentadecatrienyl salicyl alcohol butyl ether, 6-pentadecatrienyl salicylaldehyde methyl ether, 6 -Pentadecatrienyl salicylaldehyde ethyl ether, 6-pentadecatrienyl salicylaldehyde propyl ether, 6-pentadecatrienyl salicylaldehyde butyl ether, 2- Tyl ether-6-pentadecatrienyl cinnamic acid, 2-ethyl ether-6-pentadecatrienyl cinnamic acid, 2-propyl ether-6-pentadecatrienyl cinnamic acid, 2-butyl ether-6-pentadeca Trienylcinnamic acid, 2-methyl ether-6-pentadecatrienyl cinnamic alcohol, 2-ethyl ether-6-pentadecatrienyl cinnamic alcohol, 2-propyl ether-6-pentadecatrienyl cinnamic alcohol , 2-butyl ether-6-pentadecatrienyl] cinnamic alcohol, etc.), polyisoprenylated benzophenone derivatives (garcinol, isogarcinol, xanthothymol, isoxanthothymol, gucciferon, etc.), stilbene derivatives or salts thereof Morgine or a salt thereof and derivatives thereof, N-acetylglucosamine.

  Phospholipids (phosphatidylethanol, phosphatidylcholine, phosphatidyltriethanolamine, phosphatidylserine, phosphatidic acid, phosphatidylglycerol, phosphatidylinositol, diacylphosphatidylcholine, diacylphosphatidylethanolamine, diacylphosphatidylinositol, diacylphosphatidylserine, 1-cysteinylphosphatidic acid 2-cysteinyl phosphatidic acid, 1-glutathionyl phosphatidic acid, 2-glutathionyl phosphatidic acid, 1-azelaoyl phosphatidic acid, 2-azelaoil phosphatidic acid, 1-hydroxyacyl phosphatidic acid, 2-hydroxyacyl phosphatidine Acid, ceramide, glucosylceramide, galactosylceramide, cerebroside, phosphati Luglucosyl acylglycerol, N-oleoyl sphingosine, N- (12-hydroxyoctadecanoyl) sphingosine, N- (16-hydroxyhexadecanoyl) sphingosine, N-salicyloylphytosphingosine, sphingomyelin, soy lecithin, egg yolk Lecithin, etc.), sterins (cholesterol, dihydrocholesterol, cholesteryl stearate, cholesteryl hydroxystearate, macadamia nut oil fatty acid cholesteryl, β-sitosterol, stigmasterol, campesterol, ergosterol, 5-dihydroergosterol, phytosterol, 25- Hydroxycholesterol, 26-hydroxycholesterol, 19-hydroxycholesterol, 22-ketocholesterol oxime, 6-ketocholesterol and 7-ketocholes Rolls or derivatives thereof), N-acetylneuraminic acid (sialic acid), N-glucosolneuraminic acid, gangliosides (galaose, ganglytriaose, gangliotetraose, globotetraose, neolactotetraose, neo Lactohexaose, neolactooctaose, etc.), oligosulfated hyaluronic acid, hydroxytamoxifen compounds, glyceroglycolipids, pentoxyferrin, 3-deazaadenosine, carboxysamide derivatives, inositol polyamines, sialic acid, triterpenic acid Derivatives, lactose, lactosamine derivatives, sulfated chitin derivatives, albumin.

  Tropolone and its derivatives, guanidine, ethanolamine, aminoguanidine, flavanones (naringin, naringenin, naringin, naringenin, liquiritin, liquiritigenin, digallic acid, luteic acid, ellagic acid, chlorogenic acid, glucogallin, tetralin, hamamelitannin, gallic acid Acid tannin, tannic acid, geraniin, gallic acid, galloyl gallic acid, ellagitannin, hexagalloylglucose, heptagalloylglucose, tetragalloylglucose, triggerroylglucose, pentagalloylglucose, digalloylquinic acid, triggerroylquinic acid) 2-hydroxyphenylalkylamine derivatives or salts thereof, phenylpropenoic acid derivatives (3- [2,3-bis (methoxymethoxy) phenyl] propenoic acid, 7- (4-hydroxy-3-methoxyphenyl) Henyl-2,4,6-trienoic acid, 3- (3,5-dimethoxy-4-hydroxyphenyl) propenohydrazide, N'-isopropylidene-3- (2-methoxyphenyl) propenohydrazide, etc.) Γ-amino-β-hydroxybutyric acid esters (γ-amino-β-hydroxybutyric acid methyl ester, γ-amino-β-hydroxybutyric acid ethyl ester, γ-amino-β-hydroxybutyric acid propyl ester, γ-amino-β -Hydroxybutyric acid butyl ester, γ-amino-β-hydroxybutyric acid ethylhexyl ester, γ-amino-β-hydroxybutyric acid hexadecyl ester, γ-amino-β-hydroxybutyric acid lauryl ester, γ-amino-β-hydroxybutyric acid stearyl ester Γ-amino-β-hydroxybutyric acid oleyl ester, γ-amino-β-hydroxybutyric acid benzyl ester, γ-amino-β-hydroxybutyric acid phenyl ester, Roh -β- hydroxybutyrate glycol ester, .gamma.-amino -β- hydroxybutyric acid sorbitol ester, .gamma.-amino -β- hydroxybutyric acid polyoxyethylene glycol ester, .gamma.-amino -β- hydroxybutyric acid glycerin ester, etc.).

  Amine oxides (oleyl dimethylamine oxide, stearyl dimethylamine oxide, palmityl dimethylamine oxide, myristyl dimethylamine oxide, lauryl dimethylamine oxide, dimethyl lauryl ethoxyamine oxide, dihydroxyethyl lauryl amine oxide, coconut oil alkyl dimethylamine oxide, etc.) , Alkyl betaines (coconut oil fatty acid amide propyl betaine, coconut oil alkyl betaine, lauryl dimethylaminoacetic acid betaine, lauric acid amidopropyl betaine, lauryl hydroxysulfobetaine, 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium Betaine), pyrimidine N-oxide derivatives (2-amino-4-methyl-6-piperidinopyrimidine-3-oxide, 2-amino-4-methyl-6- (1-pyrrolidini) P) pyrimidine-3-oxide, 2-amino-4-methyl-6-morpholinopyrimidine-3-oxide, 2-amino-4-methyl-6- [1- (4-methylpiperazinyl)] pyrimidine- 3-oxide, 2-amino-4- (1-hexahydroazepinyl) -6-methylpyrimidine-1-oxide, 2-amino-4-dimethylamino-6-methylpyrimidine-1-oxide, 2-amino -4-allylamino-6-methylpyrimidine-1-oxide, 2-amino-4-benzylamino-6-methylpyrimidine-1-oxide, 2-amino-4,5-methyl-6-piperidinopyrimidine-3 -Oxide, 2-amino-4-ethyl-6-morpholinopyrimidine-3-oxide, 2-amino-4-methyl-5-nitro-6-piperidinopyrimidine-3-oxide, 2,5-diamino- 4-methyl-6-piperidinopyrimidine-3-oxide, 2-amino-4-methyl-5,6-bis (1-pyrodinyl) pyrimidine-3-oxide, 2-amino-4-methyl-5-piperidino -6- (1- Loridinyl) pyrimidine-3-oxide, 2-methyl-4-amino-6-piperidinopyrimidine-3-oxide, 2-methyl-4-amino-5-bromo-6- (1-pyrodinyl) pyrimidine-3- Oxide, 2-methyl-4-amino-5-nitro-6-piperidinopyrimidine-3-oxide, 2-methyl-4,5-diamino-6-piperidinopyrimidine-3-oxide, 2-methyl- 4-amino-5,6-bis (1-pyrrolidinyl) pyrimidine-3-oxide, 2-amino-4-methyl-6-piperidinopyrimidine-3-oxide monohydrochloride, 2-acetylamino-4-methyl -6-piperidinopyrimidine-3-oxide, 2,4-diamino-6-phenoxypyrimidine-3-oxide, 2,4-diamino-6- (2,4-dichlorophenoxy) pyrimidine-3-oxide, 2 , 4-Diamino-6- (2,4,6-trichlorophenoxy) pyrimidine-3-oxide, 2,4-diamino-5-nitroso-6- (2,4-dichlorophenoxy) pyrimidine-3-oxide 2,4-Diamino-5-nitro-6- (2,4,6-trichlorophenoxy) pyrimidine-3-oxide, 2,4-diamino-5-nitro-6- (2,4-dichlorophenoxy) pyrimidine- 3-oxide, 2,4,5-triamino-6- (2,4-dichlorophenoxy) pyrimidine-3-oxide, 2,4-diamino-5-bromo-6- (2,4-dichlorophenoxy) pyrimidine- 3-oxide etc.), p-menthane-3,8-diol, monoglyceryl-D-glucoside monotridecanoate, 1-oN-pentadecylglycero-D-glucoside, monopentadecanoic acid glyceride sulfate, etc. Glyceride sulfate.

  Monopentadecyl glyceryl ether sulfate, 1-o-hexadecyl-2-o-methyl glycerol, 1-o-octadecyl-2-o-methyl glycerol, 1-o-oleyl-2-o -Methylglycerol, acetylcarnitine or its salt, geranylgeranylacetone, hydroxamic acid derivative or its salt, gingerone glycoside, benzeneoxyacetic acid derivative ([5- [2- [1-phenyl-1- (3-pyridyl) Methylideneaminooxy] ethyl] -7,8-dihydronaphthalen-1-yloxy] acetic acid), isorhamnetin-3-robinobioside, xanthone derivatives, proanthocyanidins (grape seed extract proanthocyanidins, apple-derived proanthocyanidins, pine-derived Proanthocyanidins, purified procyanidin oligomers, procyanidins B-1, procyanidins B-2, procyanidins B-3, procyanidins C-1 ), Phthalazinones, benzoxazinone compounds, phosphonic acid derivatives, cyproterone, 5.alpha.-androstene-3.alpha, 17.beta.-diol, medroxyprogesterone, norethisterone, Mesutanoron.

  Chicken crown extract, bovine, porcine or human placenta extract, porcine or bovine stomach, duodenum, intestine, spleen extract or degradation product thereof, bovine or porcine brain tissue extract, collagen derivatives such as water-soluble collagen, acylated collagen Collagen hydrolyzate, elastin, elastin hydrolyzate, water-soluble elastin derivative, keratin and its degradation product or their derivatives, silk protein and its degradation product or their derivatives, porcine or bovine blood cell protein degradation product (globin peptide ), Cattle or porcine hemoglobin degradation products (hemin, hematin, heme, protoheme, heme iron, etc.), milk, casein and degradation products thereof or derivatives thereof, skim milk powder and degradation products thereof or derivatives thereof, lactoferrin or degradation thereof , Egg component, fish decomposition product, yeast metabolite, yeast extract, bacterial metabolite, bacterial extract, mold Or metabolites such as mushrooms, actinomycete metabolites, extracts such as fungi or mushrooms, actinomycetes extract, natto metabolites, natto extract, rice fermentation extract, rice bran (red potato, white birch) fermentation extract, euglena extract Or a decomposed product thereof or a water-soluble derivative thereof, a lactic acid fermented product of raw milk or skim milk powder, trehalose or a derivative thereof.

  Seawater such as deep seawater, for example, sea salt, dried seawater, dead sea or Atlantic or Pacific sea water (sodium chloride, magnesium chloride, potassium chloride, etc.), sea mud or mud (fango), for example Sea mud or mud from various parts of Italy, Fango, German Fango, Eifel Fango, Freiburg Fango, etc. (Content: silicon dioxide, titanium dioxide, aluminum oxide, iron oxide, manganese oxide, sodium oxide, potassium oxide, magnesium oxide, calcium oxide Substances derived from natural products such as marine components such as strontium oxide, sodium, potassium, magnesium, calcium, chromium, iron, copper, nickel, zinc, lead, manganese, arsenic, water) and saintoku stone.

Almond extract, Ammarok extract, Oyo-yoyo extract, Ovana okera extract, Okera extract, Konfuyo extract, Uncaria extract, Geigicha extract, Gypsophila extract, Licorice extract, Kranigean extract, Koganebana (Ogon) extract , Wheat (wheat) extract, rice (rice) extract, Koreaia extract, Sidwaya extract, sun cucumber extract, sanvitro extract, sun pens extract, silane (bikkyu) extract, senkyu (river cucumber) extract, senna extract, senpukuka extract, sen Japanese cypress extract, Surigatin extract, Nodake (mae-hu) extract, pearl barley (yokuinin) extract, hamago extract, honey bee moth (vine bud) extract, palm extract, parietalia extract, safflower (safflower) extract, mugwa (mulberry) White skin) extract, malvano Jajin (bitter ginseng) extract, purple squirrel extract, white squirrels extract, mugwort mugwort extract, yashajitsu extract, hongkong extract, bitumen extract (dianthus) extract, yuzuriha extract, muskweed extract, millipede extract, acacia extract, acerola extract, ichibi ( (Winter position) extract, weeping birch extract, quercus (gallic) extract, chestnut extract, tortoise prickly extract, black beetle extract, toad (extended herb) extract, seri extract, buckwheat extract, dabilia extract, nazuna extract, fujibakama (Orchid grass) extract, chamomile extract , Mulberry extract, bituminous extract, mugwort extract, honeysuckle extract, pine pod extract, pearl barley extract, altea extract, cinnamon extract, mankaishi extract, yamagwa extract, bellflower extract, toshishi extract, sequel extract Shot dried extract, Mao extract, Senku extract, Dokatsu extract, Psycho extract, Bow-fu extract, Hamabou-fu extract, Ogon extract, Peony extract, Gennoshoko extract, Kuzukuni extract, Licorice extract, Pyramid extract, Aloe extract, Shouma extract, Safflower extract, Green tea extract , Black tea extract, asen drug extract, anise extract, aloe extract, Japanese knotweed extract, seaweed extract, shrimp extract, ketsumeishi extract, ogi (yellow cocoon) extract, yellow-bellied extract, yellow-crowned cucumber extract , Onamomi extract, Oni yagara extract, Oyster extract, Mulberry extract, Cornflower extract, Catfish extract, Gansu extract, Kansui extract, Kuromoji extract, Kuromoji extract Extract, sa Colander extract, saxima button leopard extract, synapse button lee extract, Chinese pear extract (wei Sensen) extract, Oshima cherry extract, Oya cherry extract, bean cherry extract, Takane cherry extract, kohigan extract, Sato cherry extract, Zion (purple lees) extract, palm extract , White-bellied extract, ginseng extract, corn-shiba extract, dragonfly extract, toshishi extract, legume extract, pear extract, sagebrush extract, yarrow extract, linden extract, dill extract, honey beetle extract, kingfish Extract, Hitotsuba (stone persimmon) extract, Himegama (koi) extract, peony extract, floral blanca extract, hamula extract, sagebrush extract, convolvulus extract, sandalwood Extract, Mannentake (Ganoderma biloba) extract, Japanese eelfish (benuse) extract, Japanese willow extract, Japanese willow extract, Japanese willow extract, Japanese dog willow extract, Japanese willow extract, Japanese willow extract, Japanese willow extract, Japanese willow extract, Japanese willow extract, Japanese willow extract Timber king willow extract, fox willow extract, dronox extract, bayberry (cold ume skin) extract, agave mid-autumn, aon agave extract, fuchlin agave extract, mitsumata extract, aonori extract, usa bay aoori extract, shiraonoori extract, hiraaoori nori Extract, Hosoeda Aonori Extract, Kombu Extract, Macombu Extract, Resilicon Extract, Hosome Kombu Extract, Mitsuishi Kombu Extract, Wakame Extract, Hiro Extract, green turtle extract, hijiki extract, hibamata extract, sea urchin extract, sea urchin extract, sea urchin extract, red sea urchin extract, sea urchin extract, sea urchin extract, sea urchin extract, sea urchin extract Amakusa Giraffe Extract, Giraffe Rhinoceros Extract, Juniper Ginseng Ripe Extract, Tsunomata Extract, Ibottsu no Mata Extract, Marubatsu No Mata Extract, Hiratokotoji Extract, Sugi Nori Extract, Shikinori Extract, Kainori Extract, Yakuzusa Extract, Uraboshiya Haz Extract, Sea Urchin Extract Extract, Atsumi miscomb extract, Isomoku extract, Nagashima moku extract, Shida moku extract, Nejimoku extract, Narasamo extract, Ma Tawara extract, sea cucumber extract, yamatamamok extract, umitranoo extract, petrel mushroom extract, fusiform moss extract, haha moku extract, yoremoku extract, sawtooth moku extract, plantain mokumoku extract, mucadenori extract, nuraxa extract, chronula extract, ommatode extract Giant tiger beetle extract, sponge beetle extract, fushitsu nagi extract, himefu tsu nagi extract, hiroha futsutsu nagi extract, black zozo extract, kubsozo extract, hanazozo extract, sozonohana extract, hazels mushroom extract Leo Verde extract, Nabnegro extract, Udo extract, Shishido extract, Gashou extract, Oak extract, Bovine taxium extract, Cuckoo thistle Kisses, scallops extract, Gymnema sylvestre extract, Carosaurus extract, Ginkgo biloba extract, Konronka extract, Saungryo extract, Jasmine (Matsurika) extract, hollyhock extract, Syuraito extract, Arabidopsis extract, Lily of the valley extract , Deco extract, Eucommia extract, Nagii Kada (Butcher Bloom) extract, Teppo cucumber extract, Tokiwa mansaku extract, Nankin goby extract, Niwa urushi extract, Nadeshiko extract, Michiyanagi extract, Niwayanagi extract, Morohaya extract (Hara) extract, Tachiyanagi extract Extract, magnolia extract, Yakuzou extract, Tamakifujime extract, Ryo kauou extract, ajigusa extract, shellfish extract (cockle extract, green mussel extract, yogi Lopagaki extract, scallop extract, clam extract, clam extract, bakagai extract, swordfish extract, red oyster extract, abalone extract, tuna extract, bi-extract, etc.) Red red hemp) extract, red clover extract, Aki larch extract, Aguahe (Omanten palm) extract, Malva morning glory extract, morning glory (Chicken) extract, Athira (Shokuyo kanna) extract, oilseed rape extract, Amachazul extract, Amana extract Amaranthus Hippochondria, Amaranthus extract, Amaranthus extract, Amaranthus extract, Amaranthus extract, Amaranthus extract Extract, Aristolomeria extract, Alcana extract, Algarrobo extract, Aloe vera extract, rush extract, Yew extract , Dog mint extract, sardine tobacco (Iwabuchi) extract, iwahiba extract, sardine pine (roll mushroom) extract, wheat (chibusanoki) extract, duckweed (float) extract, euglena thrips extract, unyadegato (unkalia) extract, enokitake (potato) Extract, eringi extract, pre-lotus eringi extract, ogatahouken extract, oguruma (civil fragrance) extract, euglena (cereal essence) extract, oka extract, okazeli (serpentine) extract, okra extract, onidokoroko extract, tokoro extract, Nagadokoro Kiss, Onionis extract, Oyoko extract, Oyster extract, Ginseng extract, Gaku hydrangea extract, Cascaraca grada extract, Gypsophila extract, Panax ginseng extract, Kaniwa extract, Carnation extract, Gerbera extract, Camcam (camo duck) extract, Color extract, Oat extract, Karin extract, Kawara Psycho extract, Kawadashi extract, Kawaranadeshiko (stone bamboo) extract, Ezokawara deshiko (soba, buckwheat) extract, Kantarasa extract, Kikutaniku extract, Quinoa (Quinoa) ) Extract, cabbage extract, kiwi extract, gyory (Nishikawa willow, dairyagi) extract, Kiran Sou (golden grass weed) extract, guayule extract, cedar quail (Tenmon winter) extract, kudzu (Kazunori) extract, ox carrot (yellow flower bud) extract, The Ass extract, Gumbai tuna (Sekimei, Sekimeishi) extract, Kemponashi (Kigushi) extract, Gekkavidin (Monthly beauty) extract, Koolen (Huo Ren) extract, Coconut extract, Cosmos extract, Coconut krill extract, Rice oil extract, Konjac extract, Saffron ( (Bansai flower, West red flower) extract, Sapodilla extract, Sangre de Grado (croton) extract, Sancynin carrot (37 ginseng) extract, Shea (carite) extract, Cyanoki extract, Shiitake mushroom extract, Shimeji extract, Hinshimeji extract, Shakashimeji extract, Hatake shimeji extract, oshiroi shimeji extract, beech shimeji extract, honjimeshi extract, white bamboo shoot extract, shimokurene extract, saishin extract, cactus extract, janohi (barley winter) extract, shrimp knotweed extract, jujube Rhinoceros (Tsuneyama) extract, white-faced butterfly extract, white-leafed adzuki bean (chicken bone) extract, ginkgo biloba (Mizuka, Mirika flower, Shencho flower) extract, Suzu-Psycho (Xuchou) extract, purslane (horse tooth soap, horse tooth soap) extract, secek Extract Extract, Takasaburo Extract, Tachidokoro (Hikai) Extract, Dahlia (Tenjiku Button) Extract, Talwei Extract, Senganshi Extract, Sojutsu Extract, Chankapiedra (Kidachikomikanso) Extract, Tulip Extract, Chorogi Extract, Tsukurita (Mushroom) extract, camellia extract, clover (lacquered licorice) extract, tonabena (river cut) extract, corn extract, corn hair (southern cocoon) extract, toxa (wood bandits) extract, ash (crustacean) extract, turkish leopard extract, Solid bean extract, vertical blade (sword bean) extract, jujube (large cocoon) extract, navena (continuous) extract, sea cucumber extract, ramban ramie (hemp) extract, iois violet extract, nutmeg extract, nem extract, neb extract, nebi extract, nemrunoki Extracts (Prunus japonicus) extract, balsamina (crane licorice, bitter gourd) extract, harlindough extract, handdai kai (sea bream) extract, hygurum dahlia extract, beet extract, hiba extract, sunflower extract, bell pepper extract, himeuzu (tendon) extract, himematsutake, kawariharatake, Hiromatsutake extract, Fuyuminatsukusatake (Cycium Cordyceps) extract, Brazilian licorice extract, hazelnut extract, loofah extract, bumblebee extract, nettle extract (sparkling) extract, scallop extract, narcissus extract, nendorus extract, scallop extract , Spinach (acupuncture, acute pupa, periosteum) extract, falcon leaf extract, Hosoba-Kirinso (Keiten 37) extract, jojoba extract, Borage extract, Bordeaux extract, Hononiku (meat juju, large art) extract , Honsekoku (iron skin stone, sparrow mountain stone cocoon) extract, maca extract, macadamia nut extract, margaret (mokushungiku) extract, tamanozenhalen extract, kyukonkinren
Mosquito extract, matababi extract, pine coconut extract, matsuhodo cocoon extract, matico (cordon sillo) extract, quince extract, malein (biloud musk squid) extract, mansagna (andesca mite) extract, mizusobako extract, mizuasagao (dragon) Tongue extract), green mint extract, wheat straw extract, munya extract, murasakiki kibu extract, murmur sakikibu extract Extract, Palm Extract, Yabu Tobacco (Tsuruga, Tenmeisei) Extract, Mokka Extract, Lily Extract, Raigan (Raimaru) Extract, Lime Extract, Rye Extract, Raccoon Extract, Shallot Extract, Apple Extract, Gentian Extract, Ganoderma ( litchi , Toothpick extract), Astragalus extract, Yokuinin extract, Mini Sasanishiki extract, Chlorella vulgaris extract, Chlorella pyrenoid extract, Chlorella ellipsoidia extract, Macrocystis pirifera extract, Euquiri extract, Tosakanori extract, Cypress extract, Amakusa Nori extract, Ao-midro extract, Kawanori extract, Marimo extract, Motsukiki-e extract, Ezoyahaz extract, Habanori extract, Atlantic havanori extract, Cotton bud extract, Aname extract, Sugime extract, Trolocomb extract, Antocume extract, Tsuruarame extract, Kuroshiome extract, Necoa sicomb extract , Ainu Wakame extract, Chigaiso extract, Ezoi Shige extract, Yabanemoku extract, Trumpet extract, Uganomok extract, Joromoku extract, Japanese mackerel Moku Extract, Tamanashimoku Extract, Honda Walla Extract, Sugi Moku Extract, Bovine Kenori Extract, Susabi Nori Extract, Akebono Mozuku Extract, Cypridina Extract, Fusanori Extract, Hoso-Banamino Hana Extract, Hanafunori Extract, Itohnori Extract, Kaginori Extract, Mirin Extract, Hoso-boshi-Mirain Extract Extract, Ezonameshi Extract, Ibaranori Extract, Kagibaranori Extract, Saidaibara Extract, Tachiibara Extract, Ogonori Extract, Tsurushiramo Extract, Bee-winged Salamander Extract, Otsunori Extract, Red-backed Ginseng Extract, Loofah Water, Birch (White Birch) or Akamatsu Sap, barley (barley) extract, oakuri higotai (Zhengzhou leakage, indigo piercing) extract, bark beetle extract, Dutch honeybee extract, garcinia extract, mosquito Lanin ginseng extract, oyster extract, quilla extract, quince extract, ginkgo biloba extract, calendula extract, sakane ran extract Pineapple extract, Chinese cabbage extract, Japanese cypress (shooting) extract, beech extract, physalis (Torone) extract, maitake (maiko) extract, misohagi (chikuma) extract, mugwort (mushroom) extract, mukuroji (prolonged skin) extract, Palm extract, Eucalyptus extract, Suabisimus extract, Lettuce extract, Aloe extract, Ogon extract, Tonka bean extract, Burdock extract, Yakuinin extract, Senbu extract, Achacha extract, Hypericum extract, Sanadagusa extract, Fukurimami Extract, rattle comb extract, oyster comb extract, oni kombu extract, gohei kumbu extract, nagacombu extract, pea kumbu extract, bigi kumbu extract, rattle extract, rattle extract, benimozuku extract, hosobenimozuku extract, kagekinori extract , Ezotosaka extract, Silamo extract, Birch extract, Akebi (Atsubi) extract, Achacha (Amacha) extract, Dutch biloba extract, kanran extract, Kumquat extract, Gobaishi extract, Ganoderma biloba extract, Sesame extract, Sesame cell extract, Sesame seed (Ginseng) extract, rice bran extract, pomegranate extract, pear extract, Daio (Dahi) extract, tomato extract, Nanten (Nami Tenji) extract, Noazami (Daisen) extract, Neubara (fruit) extract, paprika extract, pista O extract, betel wax (big rind, coconut) extract, Japanese cypress extract, bokeh (wooden) extract, Hosobao guruma extract, mao (mao) extract, mimosa extract, mebogi extract, himeuma willow extract, willow deer extract, cotton wisteria Extract, Chlamydomonas extract, red crested extract, red clover extract, red clover extract, hypericum extract, enamel extract, birch extract, southern berry extract, clove extract, red clover (logwood) extract, red clover (red bud) extract, red clover Extract, Acacia extract, Akane (Herbus Root) extract, Hydrangea (hydrangea) extract, Abemaki extract, Fig extract, Asparagus extract, Japanese apricot (Plum) extract, Vulgari extract, Estragon extract, Enju extract Oak extract Free (Spain) extract, Sasa (Spider) extract, Perilla extract, Japanese radish extract, Chile miso extract, Catamen diso extract, Quercus extract, Cranberry extract, Crape myrtle extract, Zicopi extract, Shirakashi extract, White clover (Clover) extract, Horseradish Extract, black tea extract, green tea extract, camellia extract, tencha (boiled tea) extract, tender eel extract, nani waibara (gold cherry) extract, peanut (peanut) extract, kei extract, nikkei extract, ceylon nicki extract, yabuni Lee (Cinnamon) extract, Keishi (Keishi branch) extract, Nozenkazura (Ryokan flower) extract, Lotus (Lotus) extract, Chinese cabbage extract, Hadakamugi extract, Hanasuge (Komomo) extract, Hermanus (Maika flower) extract, Rose (Rose) extract , Barbasco extract, beech extract, American beech extract, European beech extract, European beech extract, convolvulus extract, scallop extract, canola extract, melon extract, evening primrose extract, snowy willow extract, orchid extract, lacanca extract, rooibos extract, Naminohana extract, Eucalyptus extract, Hosoyukari extract, Azusa extract, Basil extract, Mokko (wood fragrance) extract, Aotsuki-rafuji (wooden cocoon) extract, Thistle extract, Aletia thistle extract, Papilio thistle extract, Hazel thistle extract, Nori thistle extract, Aoba Thistle , Cacao extract, elcampuri extract, Otsuka rafuji (anti-self) extract, scallop (bamboo shoot) extract, calax salmon man extract, bellflower (kikyo, bellflower root) extract, kizuta extract, pepper (pepper) extract, cola acminata extract, sagiomodaka (Sawamata) extract, pomelo extract, sanshuyu (yamamaki) extract, tsuji rafuji extract, otsu tsuji rakuji extract, choreimaitake mushroom (potato) extract, camellia extract, primrose extract, gentian extract, rye ginseng extract, naginata kouju extract , Banana extract, Pu'er tea extract, Plum extract, Bowfu extract Extract, Spirulina extract, Aiacacio extract, Funorino Ushike extract, Himetengusa extract, Hytengusa extract, Oobusa extract, Chinoimo extract, Red grape extract, Azuki bean (red bean) extract, Altea extract, Nettle extract, Cascarilla extract, Kapok tree Guarana Extract, Ezo Strawberry Extract, Dutch Strawberry Extract, Shrimp Strawberry Extract, Nawashiro Strawberry Extract, Momiji Strawberry Extract, Kitechi Aloe Extract, Kosaihakka Extract, Cowberry (Etsutachibana) Extract, Cola Vera Extract, Sugarcane Extract, Sinah Honoki Extract, Honeysuckle (Golden Silver) (Flower, Shintofu) extract, Japanese larch extract, Dandelion extract, Centarium extract, Shirobana dandelion extract, Mouko dandelion extract, Tsuruzuki extract, Tsurutsuchiakebi Extract, Teuchigurumi Extract, Tormentilla Extract, Novara Extract, Firewood Ryu Extract, Hagoromogusa Extract, Castor Extract, Prunes Extract, Veronica Extract, Bisnaga Extract, Mansugura Extract, Mitsugasashi Extract, Myrrh Extract, Mansaku Extract, Doranagi Extract, Latania (Clamelia) Extract, Lemon Extract, Daisies Extract, Ages Extract, Propolis, Eye (Aiba) Extract, Asen Yaku (Asen Yaku) Extract, Avocado Extract, Amado Koro (Tamatake) Extract, Amiga Sayuri Extract, Baimo (Shell Mother) Extract, Iga Kozolina (Ground) (Biliary) extract, Ibukitorano extract, Echinashi (Hosobamurasakibarengiku) extract, Auren (Yellow) extract, Oguruma (turned over) extract, Hypericum (brothers cut grass) extract, Crab extract, Orange extract, Oak Extract, chamomile extract (kawasaki) extract, kawamidori extract, kawarayomogi (bamboo chin moth) extract, watercress extract, kenshi sartorii rose (earthen soil, mountain return) extract, koki-sekko-koku extract, kakuhon (kakimoto, karasumoto) extract, koryoukyo ) Extract, gosho strawberry extract, rhinoceros extract, cherries extract, jikitarisu extract, linden extract, salamander extract, Indian sage extract, shukushamitsu (sanden, shredded sand) extract, juzudama extract, shirominanten ) Extract, Iris genus extract, Hirosanega extract, Takasago Gorhihitai (Southeast Aya sashimi) extract, Takarabi extract (Tsubaki spinach) extract, Tamatsuki tsukufuji extract, Tonin extract, Chigaya extract, Toga (winter coconut) extract, Hanabishi (Shitushi, Shishitsuri) extract , Hamasuge extract, Hishi (Hishimi) extract, Bellows oyster extract, Japanese quail (South rattan) extract, Bundou (mung bean) extract, Sandalwood extract, Butcher bloom extract, Hosoba-Ara-giku extract, Mizurutennansho (Tennan star) extract, Miracle fruit extract, Munoki extract, Peach (peach) extract, Cornflower extract, Yachiyanagi extract, Mistletoe (willow parasite) extract, Yabukouji (purple gold beef) extract, Molewort extract, Mugwort (bamboo leaf) extract, Itohimehagi Extract, ft juzumo extract, tamajuzumo extract, mizuzojumo extract, urushigusa extract, geushi gursa extract, iwahige extract, akamoku extract, togemoku extract, akaba extract, maruba akaba extract, spinach extract, dull extract, una extract, belladonna extract, Japanese cypress extract, Harunire (rice bark, white skin, coconut leaf) extract, Asa (aspen) extract, Dutch mustard (cresson) extract, valerian (valerian) extract, clematis extract, bear sebassikis, rosewood extract, soybean (soybean) extract , Yam extract, yam extract, nosenhalen extract, yabgari extract, giant kelp extract, hijirimen extract, proboscis extract, haius banori extract, agi (Ayu) extract, asunaro extract, alpinia extract, katsudai (suzukuku) extract, Inubilu extract Shrimp extract (Chicken flower, chicken crown) extract, bay bay (Laurel) extract, Koushinbara (monthly flower) extract, copaiba balsam extract, wild cherry extract, ed pear extract, Japanese cherry extract, Yoshino cherry extract, Kasumi cherry extract, Kanza cherry extract, sugar beet extract, Sarashina Soma (Hemp) Extract, Shikunshi (Mikoshi) Extract, Birch Extract, Cinnamon Extract, Sorrel (Acid Model) Extract, Dandelion Extract, Soybean (Grass) Extract, Chicory Extract, Chosen Elm Extract (Tuna), Tsuruna (Apricot) Kiss, ipecac (Ipecac) extract, leek (Nilaco) extract, Negiekisu, Nomomoekisu, patchouli over extract, amaryllis (stone Hill Tsurutamasunahana) extract, cypress extract, Pimenta extract
, Ayuyu extract, Hirohaokinagusa (Bald eagle) extract, Blackberry extract, Makuri (Marine herb) extract, Magnolia sprenger extract, Mizokakushi (half-sided lotus) extract, Honey beet extract, Moso bamboo extract, Yamagobo (commercial land) extract, Yucca Extract, crocodile extract, lavender extract, forsythia extract, Sylar Forsythia spp. , Ishige extract, arame extract, tamamitaki extract, tambanori extract, katanori extract, cherry blossom extract, fujimatsumo extract, kawamozuku extract, aokawa mozuku extract, himekawa mozuku extract, yakuchi , Ashitaba (Tomorrow) extract, Ukiyara (Sanryo) extract, Himewikaku extract, Satsuma mandarin (Chen) extract, Toucan beetle (coconut) extract, Kina extract, Ginseng extract, Kumiso pod (hortiform grass) extract, Kubinjinsou extract, Kohone (river bone) extract, burdock (beef bowl, beef coconut) extract, scallop (mountain curd) extract, syringen extract, crispy hawthorn extract, symburi (pure medicinal) extract, tanjin (dansang) extract, chikutsujinjin ) Extract, tsurudokudami (what neck moth) extract, garlic (four leaf ginseng) extract, capsicum (banban) extract, red potato mochi (woman Sadako) extract, natsumikan extract, elderberry (bone graft) extract, hazelnut (lion coconut) extract, ashridokoro (rohto) Root) extract, peppermint (light load, light load) extract, hamabofu (hama breeze) extract, higota Extract, Fujimodoki (Chrysanthemum cherry, Camellia) extract, Black currant extract, Yuzu extract, Wintersweet (Waume) extract, Porcupine extract, Rosehip extract, Bud weevil extract, Nepenthes (Summer hay) extract, Greater crape myrtle (Banaba) extract, Great white hawthorn Extract, Calahoo extract, Guava extract, Goshishi (Gomicho) extract, Shazenso extract, Rose rose extract, Hinata Kozuchi (cow knee) extract, Honoki (Japanese Koshoku, Park) extract, American grape extract, European grape Extract, Yama Grape Extract, Mandarin Extract, Mishima Psycho (Shibahu) Extract, Pea Extract, Tosamodoki Extract, Ikanoashi Extract, Hosobonori Extract, Novonori Extract, Igis Extract, Keigi Extract, Harigi Extract, Hanegis Extract, Usbawa evening primrose extract, molluto rush extract, rush rush extract, weeping willow extract, willow licorice extract, primrose extract, plywood extract, moss willow extract, horseradish extract, licorice extract (Yinyokukaku) extract, Narukoyuri extract, Kajikarumabanarukoyuri (Yellow spirit) extract, Oregano extract, Oshida extract, Onji extract, Spruce extract, Crow peony (Half summer) extract, Pheasant (fruit) extract, Japanese wolfberry (Bone skin) extract, Goshuyu extract, Senega extract, Sendan extract, Tamarind extract, Tarragon extract, Datura extract (Dai yellow) extract, Hachiku (bamboo shoot) extract, Daisies (Daisy) extract, Milobaran extract, Himekuma willow extract , Mockinge , Laurel Extract, Yabusotatsu Extract, Anaaaosa Extract, Macrocystis Integrifolia Extract, Neocitus Rueto Keana Extract, Hilaxa Extract, Oat Extract, Kata Odela Extract, Yatabegusa Extract, Spotted Crab Extract, Ezotsu no Mata Extract, Toget No Mata Extract, Fusai Cotton extract, honey extract, mill extract, chromyl extract, sakibuchimir extract, nagamil extract, hiramil extract, matsumo extract, Okinawa mozuku extract, mozuku extract, fukuronori extract, kazime extract, kurofunori extract, mafnori extract, flax extract, banquet extract , Hana mint extract, breadfruit extract, Hirakotoji extract, Kototsutsu no Mata extract, Yaleus banori extract, Kagius banori extract Giusvanori extract, Amiaosa extract, Nagaosaosa extract, Hosobanosakamodoki extract, Hirohatosakamodoki extract, Yatsudegatatosakamodoki extract, Kurotosakamodoki extract, Nezashinotosakamodoki extract, Yusora extract, Etsukinotosakamodoki extract Nankaito Sakamodoki Extract, Himetosakamodoki Extract, Tochibanin Ginseng Extract, Sea Lily Extract, Sasayuri Extract, Hakata Lily Extract, Daisies Extract, Kikarasuuri (Guro-root) Extract, Fenugreek Extract, Fuji Bean (Asoame) Extract, Japanese Bean Extract, Chickpea Extract, Mung Bean Extract , Rabbit extract, Canamgra extract, Calla extract, Raspberry extract, Berry extract, Sandalwood extract, Aracasi extract, Anse extract, Honan extract, Chaaxa (single herb) extract, licorice extract, psyllium (carrot, carp grass extract), psyllium shabushi extract, olive extract, giant black-bellied extract, scallop extract, calla cucumber extract, Chinese pear extract Extract, Catalpa extract, Kukui nut extract, Camphor tree extract, Kubaba extract, Black-bellied red extract, Snapper extract, Snapdragon extract, Snapdragon extract, Kippi extract, Japanese beetle extract, Cilantro extract, Kobushi extract, Mokuren extract, Sanekazu extract , Binankazura extract, Matsubusa extract, Colombo extract, Conslango extract, Southern squirrel extract, Sweet potato extract, Sanebuto jujube extract, Sandzukon (Yamazune) Kiss, Shishigashira extract, Coriander extract, Stevia extract, Takatodai extract (Otsuka) extract, Tarayo (Oba winter blue, Ichiha tea, bitter tea, bitter tea) extract, Taranoki extract, Nigaki (Nakiki) extract, Nurde (pentose) Extract , Obaya chabushi extract, Yakumosou extract, Yamahanoki (Yamatake) extract, Longan (dragon eye meat) extract, Lokon (Yoshi, Sone) extract, Logwood extract, Lantana extract, Ichihatsu (first) extract, Kashuu extract, Kantou extract , Sanjico extract, Silamo extract, Sowjue , Hibiscus extract, Fritillary extract, Ivy extract, Violet extract, Yoremoku extract, Blueberry extract, Mango extract, Inondo extract, Elemi extract, Danmar extract, Vanilla bins extract, Pine extract, Aokazura extract , Aotenma extract, Akasuri extract, Aquine extract, Aguay guassu extract, Abiou extract, Abiurana extract, Yellow sapote extract, Ylang ylang extract, phalaenopsis extract, Uba tea extract, Ezo lily extract, Unboku extract, Elder Berry extract, Ohisasanoyuki extract, Sasanoyuki extract, Toucan cactus extract, Omiya catechu extract, Onoelan extract, Crab extract (Kana satou) extract, Karaya extract, Garyu Extracts Curcumigo / Latifolia extract, Black moth extract (rescue) extract, Kouliang extract, Sapotea mariyo extract, Salmon berry extract, Salamander extract, Sangaku cactus extract, Sunflower extract, Shunlan extract, Shozuk extract, Shirobana Ivy extract, cinchona sill bra extract, swim berry extract, star apple extract, sulgaran (oran) extract, corn butterfly extract, yad Giant extract, Sennin cactus extract, Senboku extract, Elephant rape extract, Prunus extract, Pomegranate extract, Dark sweet cherry extract, Prickly pear extract, Choco nostay extract, Datura extract, Tuxis kaneran extract, Tsuchiakebi extract, Tsuyukusa (Duck persimmon grass) extract, dubery extract, capsicum extract, tragacanth extract, triacanthus extract, nigerian berry extract, rapeseed extract, ginkgo biloba extract, pau doce extract, hakukayumatou extract, hakuberry berry extract , Batata extract, Hamakakiran extract, Balata extract, Harcan orchid extract, Pecan nut extract, chickpea extract, Gimme orchid extract, Brazilian carrot extract, Branjen extract, Fulleraria Kiss, Blond Psyllium Extract, Hetsukaran Extract, Henken Extract, Berry Extract, Persian Extract, Pervian Berg Extract, Pereschia Grandifolia Extract, Boysenberry Extract, Hausairan Extract, Pouteria Sapota Extract, Pouteria Rukuma Extract, Hosobabarengiku Extract, Wottle Berry extract, mazaran uba extract, masalan zuba do sear extract, macheira de boi extract, matta auryo extract, mulberry extract, midori sapote extract, purple corn extract, megacansa optica extract, mokukirin extract, maple ginger Extract, Morero cherry extract, Yakawamura potato extract, cornflower mint extract, Ruritama thistle Kiss, Red Currant Extract, Red Pitaya Extract, Wax Palm Extract, Logan Berry Extract, Dunaliella Dunaliella Extract, Chlorococcus Chlorococcus Extract, Anemone genus Kuwanomimo Extract, Volboxus genus Sunflower Extract, Volboxus Volbox extract, Palmera Extract, Yotsumemo Extract , Aomydra spruce extract, Tsurumimidro extract, Hibidoro spp. Extract, Magnus genus Black Ivy extract, Casanori genus Casanori extract, Mika moth extract, Collecaete extract, Budworm extract, Duckweed Chrysanthemum extract, Sayamidro extract, Kunshomo extract, Sumiremo violet extract, Green alga extract such as Hoshimidro extract, Fuchinashimidoru extract, Cyanobacteria genus Suizenjinori extract, Blue-green algae extract such as Aoko extract, Yulemo extract, Piraela genus Piraela extract, Shiomido genus Nagamisiomi Doro Extract, Iso Grape Iso Grape Extract, Isogawara Isogawara Extract, Black Spider Gung Sen Black Gashira Extract, Kashirazaki Kashiraki Extract, Muchimo Muchimo Extract, Muchimo Hiramchimo Extract, Muchimo Keribergusa Extract, Amygusa Sakibiro Amiji Extract, Commongusa Common Ragweed Extract, Chrysanthemum genus Rhizoma extract, Namimakura genus Hiranamikura extract, Someraceae genus Someraceae extract, Navarimo genus Nabari Extract Extract, Urushigusa Tobacco Rabbit Extract, Composita spp. , Shark genus shark genus extract, side genus genus side genus extract, crayfish genus genus extract, genus genus genus , Vine genus turmeric extract, scallop genus chrome extract, chrysanthemum genus chrysanthemum extract, nerecomb genus extract
Brown algae extract such as monoli extract, Amanori Upuri nori extract, Amanori Onia Manori extract, Amanori Tasa extract, Amanori Firitasa extract, Amanori Benitasa extract, Rhodocorton genus Milnobeni extract, Konahada haikonahada extract, Konahadago , Konahada spp., Rhizome spp. Tengusa Kohira extract, Tengusa Yohira extract, Tengusa genus extract, Hibiro Hibirodo extract, Hibirodo Himebiro extract, Iso Mesophyllum extract, Michiga spruce extract, Ryumonso extract, Ryumon hera ryumon extract, Niseka Kikusa Niseka Kikugusa extract, Okitsubara Okikikakubara extract, Sangomo Kakigara Gamo Genus Shiogusagoromo Extract, Iwanokawa Etukiikawanokawa Extract, Kainokawa Kainokawa Extract, Kaninote Kaninote Extract, Coralum Coral Extract, Centacum Scorpion Cade Extract, Mucadenori Hiramkade Extract, Mucadenori Genus Kuminodeum Extract, scented genus extract, scented scented extract, scented scented extract, cypress extract, genus Tabi extract, Kintoki Chabokintoki extract, Kintoki Kintoki extract, Kintoki rice berry extract, Kintoki Tosaka pine extract, Kintoki human Pinus extract, Kintoki fushikintoki extract, Kintoki genus quail extract, Kintoki Nagaga toki extract, Kintoki genus Centipede Extract, Kakreite Obakintoki Extract, Nagaobane Nagaokabane Extract, Karekigusa Karekigusa Extract, Kinuhada Kinuhada Extract, Tsukasanori Enasharimenia Extract, Tsukasanoori Otsukasanori Extract, Tsukasanoori Otsukasarihigeno Hoho Neuite extract, Chrysanthemum genus Usuginu extract, Nichou nou genus Nichou noo extract, Venetian genus Venus nago extract, Suskake Beni Suscabeni extract, Okarugusa spp. Extract, genus murasaki birch extract, genus genus sycaensis extract, genus genus genus extract, gononata genus catonary genus extract, genus genus genus sorghum Ogonori Extract, Ogonori Kubireogori Extract, Ogonori Mosaogonori Extract, Ogonori Kinubanori Extract, Fusiclenori Fusicurenori Extract, Namiiwatake Bamboo shoot extract, Saxinus genius extract, Saimi genus extract, Lotus japonica genus extract, Black-tailed sage extract, Black-billed squirrel extract, Amaranthus genus extract, Amaranthus genus extract, Amaranthus genus extract Thrips spp. Benifukuronori extract, Virginella spruce extract, Vaccinium spp. Extract, Aegonori extract, Aegonori Toigis extract, Saeda saeda extract, Chirimomidhi Chirimomi extract, Habutaenori extract, Cono-hanori extract, Suzushironori extract, Usubeniusu Beni extract, Hasujiginu Hasujiginu extract, Nagakonohanori Nagakonohanori extract, Sugiginus Suginu Extract Genus Enasidia Extract, Shimadadia Isohagi Extract, Shimadadia Shimadadia Extract, Dajimodoki Daijimodoki Extract, Makuri Makurieki , Anemone japonica extract, Anemone japonica extract, Cozanemo cozanemo extract, Cozanemo genus Isomurasaki extract, Cozanemo genus Hosokozanemo extract, Himegoke Himegoke extract, Himegoke genus Chimegoe extract, Hyodosigma genus hyodoshyde , Hyodosigus spp. Shajikumo Extract, Shirahamamo Extract, Hoshitsurimo Hoshitsurimo Extract, Rikunotanmus Extract, Flasmocha Shrimp Flask Extract, Chaboflask Moe Extract, Tripera Examples include various compounds such as axle algae extracts such as extracts, and plant extracts such as yellow algae extracts such as Hikarimo genus Hikarimo extract, animal / plant / microbe extracts, and natural product-derived substances.

  The animal / plant / microbe extract used as a physiologically active ingredient in the present invention is selected from various plant raw materials, animal raw materials, microbial raw materials, and other natural product raw materials, depending on the product type and form to be added. Processing routinely performed (e.g. grinding, milling, washing, extraction, degradation, fermentation or metabolic conversion by microorganisms, fractionation, purification, pressing, filtration, drying, powdering, granulation, dissolution, sterilization, pH adjustment , Deodorization, decolorization, etc., optionally selected and combined).

  Among animal / plant / microbe extracts used as physiologically active ingredients in the present invention, for plant extracts, various parts of the plant used for production can be arbitrarily selected, for example, flowers, ears, pericarps, fruits, stems, leaves, Branches, branches and leaves, trunks, bark, rhizomes, root barks, roots, seeds, whole plants, and the like can be used. In addition, for the animal / microbe extract, the object used for the production can be arbitrarily selected, for example, an isolated body such as various cells, subcellular organelles, tissues, organs, etc. Other sites, cells, tissues, organs, metabolites and the like can also be used. Furthermore, it can be obtained by culturing cells of any site, cell, tissue, organ, etc., for example, cultured cells derived from each tissue (embryonic stem cells, fibroblasts, Langerhans cells, macrophages, epidermal cells, hepatocytes) Animal-derived cultured cells, etc.), undifferentiated cell groups, cell groups in the middle of differentiation, metabolites thereof, and the like can also be used.

  The solvent used for extraction may be selected in consideration of the intended purpose and type of the product to be provided, or the processing performed later. Usually, water, methanol, ethanol, propyl alcohol, isopropyl alcohol, butanol, isopropanol are used. Lower alcohol such as butanol or hydrous lower alcohol, propylene glycol, 1,3-butylene glycol, 1,2-butylene glycol, 1,4-butylene glycol, 1,5-pentanediol, 1,2-pentanediol, 1, Polyhydric alcohol or hydrous polyhydric alcohol such as 3-pentanediol, 1,4-pentanediol, 1,3,5-pentanetriol, glycerin, polyethylene glycol (molecular weight: 100,000 to 100,000), acetone, ethyl acetate, diethyl ether , Dimethyl ether, ethyl methyl ether, dioxane, acetonitrile Various organic solvents such as xylene, benzene, chloroform, carbon tetrachloride, phenol, toluene, acids (hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, formic acid, acetic acid, etc.) and alkalis (sodium hydroxide, It is desirable to use one or a mixture of two or more selected from potassium oxide, calcium hydroxide, ammonia and the like. However, if it is not preferable to contain an organic solvent depending on the purpose of use, use only water, or perform extraction using a highly volatile solvent that is easy to remove the solvent after extraction. It is also possible to use a method such as dissolving in a solution.

  Regarding the extraction method, the temperature of the solvent, the weight ratio of the solvent to the raw material, or the extraction time can be arbitrarily set for various raw materials and the solvent used. The temperature of the solvent can be arbitrarily set in the range of −4 ° C. to 100 ° C., but is preferably around 10 to 40 ° C. from the viewpoint of the stability of the components contained in the raw material. Also, the weight ratio of the solvent to the raw material can be arbitrarily set within the range of, for example, raw material: solvent 4: 1 to 1:10, and a weight ratio of 1: 1 to 1: 5 is particularly preferable.

  Decomposition mainly includes acid decomposition, alkali decomposition, enzyme decomposition, and high-temperature and high-pressure decomposition. In the decomposition with an acid, for example, it is preferable to use an inorganic acid or an organic acid such as hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, acetic acid, formic acid, oxalic acid, hydrogen bromide, perchloric acid, and periodic acid. In the decomposition by alkali, for example, sodium hydroxide, potassium hydroxide, calcium hydroxide, ammonium hydroxide, barium hydroxide, sodium carbonate, ammonium carbonate, calcium carbonate, magnesium hydroxide, sodium silicate, etc. are preferably used. In the decomposition with acid or alkali, the concentration, reaction time, reaction temperature, and the like can be arbitrarily set for the target raw material. In the enzymatic degradation, it is preferable to use an enzyme having a function of degrading proteins, polysaccharides, lipids or complexes thereof having an important function particularly with respect to cell structure, tissue structure, etc., for example, aminopeptidase, dipeptidase, dipeptide Peptidyl peptidase, tripeptidyl peptidase, carboxypeptidase, serine protease, trypsin, chymotrypsin, cysteine protease, thiol protease, papain, aspartate endopeptidase, metalloendopeptidase, promeline, thermolysin, pronase, pepsin, rennin, Proteolytic enzymes (proteases) such as pancreatin, chymopapain, ficin, collagenase, elastase, amylase, takaamylase, cellulase, hemicellular , Pectinase, polygalacturonase, dextranase, pralanase and other polysaccharide-degrading enzymes, chicken egg white lysozyme, human lysozyme, papaya lysozyme, cabra lysozyme, barley lysozyme, zymolace, lysozyme chloride, glucanase, glucouron Examples thereof include cell wall lytic enzymes such as oxidase, chitinase, and kilosanase. In the degradation with an enzyme, the concentration, reaction time, reaction temperature, pH of the solution, etc. can be arbitrarily set, but it is particularly preferable to set the optimum value for the enzyme used.

Fermentation or metabolic conversion by microorganisms can be performed by inoculating at least one or more kinds of microorganisms on plant-based raw materials, animal-based raw materials, or processed products thereof, and growing them. Inoculation of microorganisms to the substrate can be done by adding microorganisms directly into the substrate, or by adsorbing them on a carrier such as alginic acid, polyvinyl, gelatin, etc., for example, in the form of fine beads composed of microorganisms and carrier. Further, it can be used by being fixed to the tube wall of the bioreactor. Fermentation or metabolic conversion by microorganisms is not particularly defined as a microorganism to be used, but can generally be defined as microorganisms other than pathogenic microorganisms that exhibit significant toxicity to living bodies. Examples of microorganisms to be used include, but are not limited to, yeasts classified into the genus Aciculoconidium, Actonia, Aessosporon, Ambrosiozyma, Amphierna, Anthomyces, Apiotrichum, Arthroascus, Arxula, Ascotrichosporon, Ashbia, Ashbya Genus, Asporomyces, Atelosaccharomyces, Azymocandida, Azymohansenula, Azymomyces, Azymoprocandida, Babjevia, Ballistosporomyces, Basidiotrichosporon, Bensingtonia, Blastobotrysbota, Blastodlastrzo Brettanomyces (Brettanomyces bruxellensis, Brettanomyces anomalus etc.), Bullera, Bulleromyces, Candida (Candida albicans, Candida amylolenta, Candida anomala, Candida boidinii, Candida entomaea, Candida etchellsment, Candida etchellsii, Candida etchellsment Candida intermedia, Candida krusei, Candida lactosa, Candida lipolytica, Candida mogii ), Candida parapsilosis, Candida sake, Candida tropicalis, Candida versatilis, Candida vulgaris, etc. , Debaryomyces hansenii, etc.), Debaryozyma, Dekkera, Dekkeromyces, Dematium, Dipodascus, Eeniella, Enantiothamnus, Endoblastoderma, Endoblastomyces, Endomyces, Endomycopsis, Endyllium, Entelexis, Emas , Eutorula, Eutorulopsis, Fabospora, Fellomyces, Fermentotrichon, Filobasidium, Galactomyces, Geotrichoides, Geotrichum, Guilliermondella, Hanseniaspora, HansenulaHanula, HansenulaHanula, Hansenula wickerhamii etc.), Hypomyces genus, Issatchenkia genus, Kloeckera genus (Kloeckera brevis, Kloeckera fluorescens) , Kloeckera japonica, etc.), Kloeckeraspora, Kluyveromyces (Kluyveromyces bulgaricus, Kluyveromyces marxianus, Kluyveromyces thermotolerans, etc.), Kockovaella genus, Kurtzmanomyces, Leucosporidium, , Monosporella, Mrakia, Myceloblastanon, Mycocandida, Mycoderma, Mycotorula, Mycokluyveria, Mycotoruloides, Myxozyma, Nadsonia, Nectaromyces, Nematospora, Octosporomyces, Ogataea, O, Genus, Pachysolen genus, Parasaccharomyces genus, Paratorulopsis genus, Parendomyces sp Genus, Pseudohansenula, Pseudomonilia, Pseudomycoderma, Pseudosaccharomyces, Pseudozyma, Rhodomy Genus ces, Rhodosporidium, Genus Rhodotorula, Saccharomyces (genus Saccharomyces aceti, Saccharomyces cerasi, Saccharomyces cerevisiae, Saccharomyces exiguus, Saccharomyces unisporus, Saccharomyces fibuligera, etc.), Saccharomyces Selenotila genus, Selenozyma genus, Smithiozyma genus, Sporidiobolus genus, Sporobolomyces genus, Sporothrix genus, Stephanoascus genus, Sterigmatomyces genus, Sympodiomyces genus, Symringospora genus, Tetrapisispora genus, Torulaspora genus, Tordenpsiron genus, Torulopsiron genus, Torulopsis genus Genus Waltomyces, Willia, Willopsis, Wingea, Xanthophyllomyces, Yamadazyma, Zendera, Zygofabospora, Zygopichia, Zygohansenula, Zygorenospora, Zygosaccharomyces, Zymodebaryces, etc. The microorganisms classified as bacteria include the genus Acetobacter (Acetobacter aceti, etc.), Achromobacter genus, Acidianus genus, Acidobacterium genus, Acidithiobacillus genus, Acrocarpospora genus, Actinoalloteichus genus, Actinocorallia genus, Actinokineospora genus, Actinomadospura genus, Actinomadspura Actinosynnema genus, Aerococcus genus, Aeromicrobium genus, Agrobacterium genus, Agromyces genus, Ahrensia genus, Alcaligenes genus, Alicyclobacillus genus, Alloiococcus spp. , Aureobacterium genus, Azotobacter genus, Bacteroides genus, Bacillus genus (Bacillus brevis, Bacillus subtilis etc.), Beneckea genus, Bifidobacterium genus (Bifidobacterium bifidum, Bifidobacterium longum, Bifidobacterium breve, Bifidobacterium infantis etc.), Brachybacterium genus, Brevicillus, Brevundimonas, Burkholderia, Carnobacterium, Catellatospora, Cellulomonas sp Enterobacter sp Genus, Halobacterium genus, Halococcus genus, Herbidospora genus, Hydrogenophilus genus, Hyphomicrobium genus, Hyphomonas genus, Intrasporangium genus, Janibacter genus, Kinesia spp. Kocuria, Kurthia, Lactobacillus (Lactobacillus rimae, Lactobacillus divergens, Lactob acillus carnis, Lactobacillus piscicola, Lactobacillus acidophilus, Lactobacillus amylophilus, Lactobacillus animalis, Lactobacillus brevis, Lactobacillus casei, Lactobacillus curvatus, Lactobacillus bulgaricus, Lactobacillus delbrueckii, Lactobacillus fermentum, Lactobacillus fructivorans, Lactobacillus fructosus, Lactobacillus helveticus, Lactobacillus hilgardii, Lactobacillus homohiochii, Lactobacillus kefiri , Lactobacillus malefermentans, Lactobacillus murinus, Lactobacillus paracasei, Lactobacillus paracasei subsp. tolerans, Lactobacillus parakefiri, Lactobacillus pentosus, Lactobacillus plantarum, Lactobacillus reuteri, Lactobacillus rhamnosus, Lactobacillus sakei, Lactobacillus confusus, Lactobacillus viridescens, Lactobacillus johnsonii, Lactobacillus viscosus, Lactobacillus bunchneri, Lactobacillus fermentatae, Lactobacillus acidophil-aerogenes, Lactobacillus leichmannii, Lactobacillus gasseri, Lactobacillus bifidus, Lactobacillus jugurt, Lactobacillus caucasicus, Lactobacillus arabinosus, Lactobacillus kunkeei, Lactobacillus nagelii, Lactobacillus fornicalis, Lactobacillus pentoaceticus, Lactobacillus xylosus, Lactobacillus minutus, etc.), Leuconostoc genus (Leuconostoc lactis, Leuconostoc dextranicum, Leuconostoc mesenteroides, Leuconostoc oenos, Leuconostoc paramesenteroides, Leuconostoc cremoris, Leuconostoc citrovorum, etc. ), Listonella, Lucibacterium, Luteococcus, Magnetospirillum, Marinilabilia, Marinospirillum, Mesorhizobium, Metallosphaera, Methylobacterium, Microbispora, Micrococcus, Microellobosporia, Micromonospora, Mycobacterium, Nocoides, Nocoides, Genus, Nonomuraea, Nonomuria, Oceanospirillum, Ochrobactrum, Oerskovia, Oligella, Paenibacillus, Pediococcus (Pediococcus halophilis, Pediococcus acidilactis, Pediococcus cerevisiae, Pediocoedus pensacedos , Peptococcus genus, Peptostreptococcus genus, Pilimelia genus, Pimelobacter genus, Planobispora genus, Planococcus genus, Planomonospora genus, Prevotella genus, Propionibacterium genus, Proteus genus, Protomonas genus, Pseudomoncardia genus, Rahnella genus, Rathella genus, Rarobacter Genus, Rhizomonas, Rhodobacter, Rhodococcus, Rhodopseudomonas, Rhodospirillum, Rothia, Rubrobacter, Ruegeria, Saccharomonospora, Saccharothrix, Serratia, Sinorhizobium Streptoalloteichus spp., Streptococcus spp. (Streptococcus durans, Streptococcus faecalis, Streptococcus faecium, Streptococcus bovis, Streptococcus equinus, Streptococcus mutans, Streptococcus salivarius, Streptococcus thermophilus, Streptococcus agalactiae, Streptococcus mitis, Streptococcus pyogenes, Streptococcus pneumoniae, Streptococcus lactis, Streptococcus dysgalactiae, Streptococc (us sanguis, Streptococcus acidominimus, Streptococcus avium, Streptococcus uberis, Streptococcus cremoris, Streptococcus diacetilactis, etc.) Examples include Thiobacillus genus, Thiomonas genus, Thiosphaera genus, Weissella genus, Xanthobacter genus, Xanthomonas genus, Zymomonas genus and the like. Microorganisms classified as non-yeast ascomycetes, basidiomycetes or incomplete fungi include Allomyces, Amoebidium, Amorphotheca, Arthroderma, Ascoidea, Ascobolus, Ascodesmis, Aspergillus, Aureobasidium, Botryosphaeria , Botryotinia, Brachybasidium, Byssochlamys, Capnodium, Ceratocystis, Ceratomyces, Chaetomium, Chrysella, Chrysocelia, Chytridium, Claviceps, Cochliobolus, Coemansia, Genus Genus, Cyttaria, Dasyspora, Derchslera, Derchmyces, Dichomyces, Dothidea, Endogone, Entomophthora, Emericella, Eupenicillium, Eurotium, Exobasidium, Gibberella, Glomus, Graphiola, Graphnoola, Harpella Helicomyces, Hellvella, Hemicarpenteles, Hyphochytrium, Hypocrea, Laboulbenia, Labyrinthula, Leptosphaeria, Leptosphaerulina, Lophodermium, Melanotaenium , Microascus, Microstroma, Medeolaria, Melampsora, Melampsporella, Morchella, Monascus, Monilinia, Monoblephalis, Mycospharella, Nannizzia, Nectria, Neolecta, Neurospora, Nodulosphaeria, Olizadium, Genus, Penicillium, Perenospora, Pestalotiopsis, Phomopsi
Genus s, Phragmidiella, Pneumocystis, Preussia, Pleospora, Puccinia, Pythium, Ravenelia, Rickia, Rhinocladiella, Rhizidiomyces, Rhizoctonia, Sclerocnista, Saprolegnia, Scleella, Sclerotin Septobasidium genus, Sordaria genus, Sporidiobolus genus, Stibella genus, Stigmatomyces genus, Sydowiella genus, Talaromayces genus, Taphrina genus, Thraustochytrium genus, Tolyposporium genus, Trichoglossum genus, Trichoma genus, Ustilago genus, Verticillium genus, Xylaria genus, etc.

  In fermentation or metabolic conversion by microorganisms, in addition to various raw materials such as plant-based materials, animal-based materials, and other natural product-based materials, the growth and metabolism of microorganisms are regulated or activated, and special biosynthesis or degradation pathways are induced. In order to achieve this, various compounds can be added to the raw material. For example, as a carbon source, a sugar or ethane such as glucose, fructose, galactose, sucrose, maltose, mannose, lactose, glycerol, starch, etc. , Hydrocarbons such as methane, propane, butane, formic acid, acetic acid, propionic acid, lauric acid, palmitic acid, fatty acids such as oleic acid, linoleic acid, linolenic acid, etc., nitrogen source, ammonium sulfate, ammonium hydrochloride, ammonium phosphate, etc. Ammonium salt, urea, uric acid, amino acids, etc. Vitamins and compounds that contain potassium, calcium, magnesium, sodium, sulfur, phosphorus, chlorine, etc., as well as iron, copper, zinc, cobalt, nickel, boron, manganese, molybdenum, tin, selenium, silicon Further, a compound containing arsenic, vanadium, chromium, fluorine or the like in the composition can be further added. In addition, the optimum temperature, oxygen supply amount, pH, pressure, etc. that affect the growth and metabolic activities of various microorganisms can be arbitrarily set according to the characteristics inherent to various microorganisms. Can be arbitrarily set within the range of 10 to 50 ° C., and the pH can be arbitrarily set within the range of 1 to 14.

  In fractionation or purification, generally known techniques can be used as appropriate. In addition to solvent extraction, for example, liquid chromatography (ion exchange chromatography, ion exclusion chromatography, affinity chromatography, gel filtration chromatography, size exclusion chromatography, etc.). Chromatography, hydrophilic adsorption chromatography, hydrophobic adsorption chromatography, ligand exchange chromatography, etc.), dialysis with semipermeable membrane, crystallization and recrystallization of components, filter paper, membrane filter, ultra filter, Examples thereof include filtration using activated carbon and filter aid, centrifugation, and density gradient separation methods such as fractional precipitation and density gradient sedimentation equilibrium, which are applications thereof.

  As preparation preparation ingredients such as colorants, surfactants, fragrances, excipients, etc., silicic anhydride, magnesium silicate, bentonite, titanium mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide, titanium oxide, carbonate Inorganic pigments such as calcium, magnesium carbonate, yellow iron oxide, bengara, black iron oxide, gunjou, chromium oxide, chromium hydroxide, carbon black, calamine, hydrogen peroxide, sodium persulfate, ammonium persulfate, sodium perborate , Urea peroxide, sodium percarbonate, sodium tripolyphosphate, sodium bromate, potassium bromate, sodium pyrophosphate, sodium peroxide orthophosphate, sodium silicate hydrogen peroxide adduct, sodium sulfate hydrogen peroxide addition Body, sodium chloride hydrogen peroxide adduct, β-Chi Sinase enzyme solution, mushroom extract, inorganic reducing agents such as strontium sulfate, sodium sulfide, barium sulfide, calcium sulfide, thioglycolic acid or its salts (calcium thioglycolate, sodium thioglycolate, lithium thioglycolate, thioglycol Redox agents such as magnesium acid and strontium thioglycolate), 5-aminoorthocresol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, 3, 3'-iminodiphenol, 2,4-diaminophenoxyethanol hydrochloride, 2,4-diaminophenol hydrochloride, toluene-2,5-diamine hydrochloride, nitroparaphenylenediamine hydrochloride, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride , Metaphenylenedia hydrochloride , Orthoaminophenol, N-phenylparaphenylenediamine acetate, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5-dihydroxynaphthalene, toluene-2,5-diamine, toluene-3,4-diamine , Nitroparaphenylenediamine, paraaminophenol, paranitroorthophenylenediamine, paraphenylenediamine, paramethylaminophenol, picramic acid, sodium picrate, N, N'-bis (4-aminophenyl) -2,5-diamino- 1,4-quinonediimine, 5- (2-hydroxyethylamino) -2-methylphenol, N-phenylparaphenylenediamine, metaaminophenol, metaphenylenediamine, 5-aminoorcresol sulfate, 2-amino-5-sulfate Nitrophenol, ortho aminophenol sulfate, orthochloroparafe sulfate Range amine, 4,4'-diaminodiphenylamine sulfate, 2,4-diaminophenol sulfate, toluene-2,5-diamine sulfate, nitroparaphenylenediamine sulfate, paraaminophenol sulfate, paranitroorthophenylenediamine sulfate, paranitrometasulfate Phenylenediamine, paraphenylenediamine sulfate, paramethylaminophenol sulfate, metaaminophenol sulfate, metaphenylenediamine sulfate, catechol, diphenylamine, α-naphthol, hydroquinone, phloroglucin, 2-hydroxy-5-nitro-2 ', 4'- Dye agents such as diaminoazobenzene-5'-sodium sulfonate and hematein.

  Natural animal fragrances such as musk, civet, castrium, ambergris, anise essential oil, angelica essential oil, ylang ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, guayakwood essential oil, cumin essential oil, black letter Essential oil, cinnamon essential oil, cinnamon essential oil, geranium essential oil, copaiba balsam essential oil, coriander essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, gingergrass essential oil, cedar essential oil, spearmint essential oil, western peppermint essential oil, dairy perfume essential oil, Tuberose essential oil, clove essential oil, orange flower essential oil, winter green essential oil, troubalsum essential oil, buttery essential oil, rose essential oil, palmarosa essential oil, cocoon essential oil, hiba essential oil, sandalwood essential oil, petit gren essential oil, bay essential oil, vetiva essential oil, bergamot essential oil, pel Vegetable flavors such as balsam essential oil, boad rose essential oil, melamine essential oil, mandarin essential oil, eucalyptus essential oil, lime essential oil, lavender essential oil, linaloe essential oil, lemongrass essential oil, lemon essential oil, rosemary essential oil, Japanese mint essential oil, and other synthetic flavors Perfume, natural alcohols such as ethanol, isopyropanol, lauryl alcohol, cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, phytosterol, phenoxyethanol, synthetic alcohols such as 2-hexyldecanol, isostearyl alcohol, 2-octyldodecanol, etc. Alcohols, isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, oleic acid Sil, octyldodecyl myristate, hexyldecyl dimethyloctanoate, diisobutyl adipate, 2-hexyldecyl adipate, diheptyl undecyl adipate, N-alkyl glycol monoisostearate, isocetyl isostearate, trimethylolpropane triisostearate, diethyl Ethylene glycol hexanoate, neopentyl glycol diethyl hexanoate, cetyl 2-ethyl hexanoate, trimethylol propane triethyl hexanoate, pentaerythritol tetraethyl hexanoate, cetyl octanoate, octyldodecyl gum, cetyl lactate, myristyl lactate, diethyl phthalate, Dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, dioleic acid Esters such as Russia propylene glycol, aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, metal soaps such as zinc undecylenate.

  5-amino-o-cresol, o-aminophenol, m-aminophenol, p-aminophenol, 2,6-diaminopyridine, 5- (2-hydroxylethylamino) -2-methylphenol, N, N-bis (β-hydroxyl) -p-phenylenediamine sulfate, N, N-bis (2-hydroxyethyl) -p-phenylenediamine, p-nitro-o-phenylenediamine, p-phenylenediamine, m-phenylenediamine, N-phenyl-p-phenylenediamine, resorcin, hydroquinone, 2-hydroxy-5-nitro-2 ', 4'-diaminoazobenzene / sodium sulfate, toluene-2,5-diamine, 2- (2'-hydroxyethylamino ) -5-aminotoluene, N, N-bis (β-hydroxyl) -p-phenylenediamine, N, N-bis (2-hydroxyethyl) -p-phenylenediamine sulfate, 5-amino-o-cresol・ Sulfate, p-aminophenol Sulfate, o-chloro-p-phenylenediamine, sulfate, 2- (2'-hydroxyethylamino) -5-aminotoluene, sulfate, 4,4'-diaminodiphenylamine, sulfate, p-methylaminophenol・ Sulfate, p-phenylenediamine / sulfate, m-phenylenediamine / sulfate, toluene-2,5-diamine / sulfate, 2,4-diaminophenoxyethanol / hydrochloride, toluene-2,5-diamine / hydrochloric acid Salt, m-phenylenediamine / hydrochloride, 2,4-diaminophenol / hydrochloride, 3,3'-iminodiphenol, p-phenylenediamine / hydrochloride, N-phenyl-p-phenylenediamine / hydrochloride, N -Phenyl-p-phenylenediamine / acetate, 1,5-dihydroxynaphthalene, toluene-3,4-diamine, p-methylaminophenol, N, N'-bis (4-aminophenyl) -2,5-diamino -1,4-quinonediimine o-Aminophenol sulfate, 2,4-diaminophenol sulfate, m-aminophenol sulfate, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-amino-4- Methylaminoanthraquinone, nitro-p-phenylenediamine / hydrochloride, 1,4-diaminoanthraquinone, nitro-p-phenylenediamine, picramic acid, sodium picrate, 2-amino-5-nitrophenol / sulfate, resorcinol, nitro -p-Phenylenediamine / sulfate, p-nitro-o-phenylenediamine / sulfate, p-nitro-m-phenylenediamine / sulfate, red No. 2, red No. 3, red No. 102, red No. 104 ( 1) Red 105 (1), Red 106, Red 201, Red 227, Red 230 (1), Red 230 (2), Red 231, Red 232, Red 401 Red 502, Red 503, Red 504, Red 506, Yellow 4, Yellow No. 5, Yellow 202 (1), Yellow 202 (2), Yellow 203, Yellow 402, Yellow 403 (1), Yellow 406, Yellow 407, Orange 205, Orange 207 , Orange 402, Green 3, Green 204, Green 205, Green 401, Green 401, Green 402, Brown 201, Purple 401, Blue 1, Blue 2, Blue 202, Blue 203, Blue No. 205, Black No. 401, Red cabbage dye, Red rice dye, Akane dye, Anato dye, Ikumi dye, Turmeric dye, Enju dye, Krill dye, Amber dye, Caramel, Gold, Silver, Gardenia dye, Corn dye, Onion dye , Tamarind dyes, spirulina dyes, buckwheat whole plant dyes, cherry dyes, laver dyes, hibiscus dyes, grape juice dyes, marigold dyes, purple potato dyes, purple yam dyes, lac dyes, rutin, etc.

  Others, hormones, sequestering agents, pH adjusters, chelating agents, antiseptic / antibacterial agents, refreshing agents, stabilizers, emulsifiers, animal / plant proteins and their degradation products, animal / plant polysaccharides and their Degradation products, animal / plant glycoproteins and their degradation products, anti-inflammatory agents, antiallergic agents, wound treatment agents, foaming agents, thickeners, enzymes, purified water (electronic water, small clustering, etc.), deodorant / A deodorant etc. can be used in combination.

  Hereinafter, the present invention will be described in more detail with reference to examples, but the present invention is not limited thereto.

Manufacture of a specific plant extract Spruce root bark, Achillea millefolium, Ginger rhizome, Horse chestnut seeds, Kara toki root, Roman chamomile flower, Walnut leaf, Arnica flower, Cinnamon flower, Oolongcha leaf, Daidai peel, Coffee roast roast Seeds, hawthorn fruit, turmeric rhizome, whole horsetail, loquat leaf, fennel fruit, gardenia fruit, carrot root, gentian root, ginkgo biloba, American witch leaf, licorice leaf, bushsouge flower, dokudami flowering ground, hop fruit, Hypericum perforatum, squirrels root, spruce leaves, stems, purple leaves, mallow flowers, wild mint leaves, merilotos whole plant, whole mint plant, mackerel root bark, peonies root, ginger root, whole rosemary Yakuyo Salvi A whole plant, elderberry flower, savonso leaves, saxifrage whole plant, clara root, crested hinoki bud, dandelion blossom, agarica japonicum above ground, scallop flower and leaf, salamander peel, lemongrass leaf and stem, oyster persimmon, ginger rhizome , Grape leaf, button root bark, yellowfin root bark, Dutch jellied leaf, spinach leaf, cucumber fruit, watermelon fruit, radish root, onion bulb bark, potato tuber, pumpkin fruit, garlic bulb, Ichigo primrose flower, alley Valerian root, whole plant, yellow-billed whole plant, evening primrose seed, walnut leaf, pansy whole plant, allied plant, white willow leaf, European raspberry fruit, red pine cone, cypress leaf, angelica root, angelica seed, Centifo Add 10 times each amount of purified water to 100g each of Avala flower, lime fruit, Bevia awelanedae bark, Eupatium purpleum root and Devil's claw root, then autoclave (121 ° C, 1.2 atmospheres pressure) 90 Extraction was performed at high temperature and high pressure, followed by filtration using filter paper to obtain an extract. Next, the obtained extract was lyophilized at -80 ° C, and the resulting dried product was dissolved in a 30 v / v% ethanol solution to a solid content concentration of 3 mg / mL, and it was tripled with purified water. Each plant extract (solid content concentration 1 mg / mL) was obtained.

Trypsin inhibitory action test
A solution obtained by dissolving 250 μmol of the synthetic substrate Boc-Phe-Ser-Arg-MCA (Peptide institute INC) in 15 mL of 50 mM Tris-HCl buffer containing 20 mM calcium chloride and 1.0 w / v% dimethyl sulfoxide. 150 μL each was added to a 96-well microplate. Next, 25 μL of each plant extract obtained in Example 1 was individually added to the same microplate, and then 25 μL of 4 μg / mL trypsin (Sigma) aqueous solution was added to each well at 25 ° C. for 15 minutes. Reacted. Next, the fluorescence intensity (Labsystems Multiskan MS-UV) at an excitation wavelength of 360 nm and a fluorescence wavelength of 450 nm was measured. Control was a system in which a 10 v / v% aqueous ethanol solution was added instead of the plant extract. The blank was a system in which a plant extract or a 10 v / v% ethanol aqueous solution was added, and no trypsin was added. And the trypsin activity inhibition rate (%) was computed from the value shown below from the value of each obtained fluorescence intensity. The results are shown in FIGS.
[formula]
Trypsin activity inhibition rate (%) = 100 × [(C−C _B ) − (S−S _B )] / (C−C _B )
C: Fluorescence intensity in control addition system C _B : Fluorescence intensity in control addition system blank S: Fluorescence intensity in plant extract addition system S _B : Fluorescence intensity in plant extract addition system blank

Results of Trypsin Inhibitory Action Test As a result of testing the trypsin inhibitory action of each plant extract, trypsin activity inhibitory action was confirmed in all plant extracts as shown in FIGS. Accordingly, it has been found that the plant extract used in the present invention can be an effective trypsin inhibitor.

(Prescription example)
Production examples of various pharmaceuticals, quasi drugs, cleaning cosmetics and foods using the trypsin inhibitor of the present invention are shown below, but the present invention is not limited thereto.

(Prescription Example 1) Capsule
Ezoukogi extract 10.0g
Fuquidan Popo Extract 10.0g
Magnesium ascorbate 0.5g
DL-α-tocopherol acetate 0.5g
Silicone oil 30.0g
Tween 80 0.05g
Corn starch 48.95g
The above ingredients were mixed uniformly and 200 mg was filled into a gelatin capsule to produce a capsule.

(Prescription Example 2) Capsule
Tokakinka Extract 10.0g
Fennel extract 5.0g
Starch 60.0g
Mannitol 10.0g
Calcium bicarbonate 5.0g
Polyvinylpyrrolidone 20.0g
The above ingredients were mixed uniformly and 200 mg was filled into a gelatin capsule to produce a capsule.

(Prescription Example 3) Tablet
Garlic extract 20.0mg
Salvia extract 80.0mg
Cornstarch 50.0mg
Hydroxypropyl methylcellulose 150.0mg
Carboxymethylchitin 30.0mg
The above ingredients were uniformly mixed and tableted to produce a tablet.

(Prescription Example 4) Tablet
Gardenia extract 50.0mg
Diou extract 50.0mg
Corn starch 80.0mg
Methylcellulose 40.0mg
Magnesium stearate 20.0mg
Talc 10.0mg
The above ingredients were uniformly mixed and tableted to produce a tablet.

(Prescription Example 5) Granule
Peonies extract 50.0mg
Carboxymethylcellulose 180.0mg
Propylene glycol 20.0mg
Sodium alginate 30.0mg
Sucrose 10.0mg
The above ingredients were uniformly mixed and granulated to produce granules.

(Prescription Example 6) Granule
Makuwa extract 20.0mg
Daidai extract 40.0mg
Carboxymethylcellulose 180.0mg
Sodium alginate 30.0mg
Erythritol 10.0mg
Citric acid 5.0mg
The above ingredients were uniformly mixed and granulated to produce granules.

(Formulation Example 7) Milk Mass%
Nettle extract 2.5
Salamander extract 1.5
Squalane 5.0
Olive oil 5.0
Jojoba oil 5.0
Cetyl alcohol 1.5
Glycerol monostearate 2.0
Polyoxyethylene (20) cetyl ether 3.0
Polyoxyethylene (20) soorbitan monooleate 2.0
1,3-butylene glycol 1.0
Glycerin 2.0
P-Hydroxybenzoate ester
Residue with 100 purified water

(Formulation Example 8) Lotion Mass%
Merilot Saw Extract 3.0
Mallow extract 1.5
Glycerin 3.0
1,3-butylene glycol 5.0
Ethanol 15.0
Iron oxide 0.2
Zinc oxide 0.5
Kaolin 2.0
Trehalose 2.0
Dextrin 0.5
Photosensitive element 201 Appropriate amount Photosensitive element 401 Appropriate amount Fragrance Appropriate amount
Residue with 100 purified water

(Prescription Example 9) Ointment Mass%
Elderberry extract 4.0
Tachikaku extract 4.0
l-Menthol 3.0
DL-Camphor 0.5
Propylene glycol 15.0
Carboxyvinyl polymer 1.0
Hydroxyethyl cellulose 0.1
Triethanolamine 0.7
Purified water 25.0
Ethanol 100 residue

(Formulation Example 10) Body cleaner Mass%
Evening primrose extract 0.5
Lemongrass extract 0.3
Sodium citrate 2.0
Potassium laurate 15.0
Potassium myristate 5.0
Propylene glycol 5.0
Sorbitol 3.0
Polyethylene powder 0.5
Hydroxypropyl chitosan solution 0.5
Preservative appropriate amount
pH adjusting agent
Residue with 100 purified water

(Prescription Example 11) Baby powder mass%
Powdered odoris extract 2.5
Powdered Arnica extract 2.0
Zinc oxide 35.0
Betaine 2.0
Eucalyptus leaf oil 1.5
Menthol 3.2
Polyethylene powder 15.5
Perfume
Remaining as talc 100

(Formulation example 12) Impregnating liquid for wet tissue
Dutch jelly extract 0.5
Makuwa extract 0.3
Ethanol 2.0
Propylene glycol 5.0
Preservative appropriate amount
A wet tissue was obtained by uniformly spraying an impregnating solution, in which the above-mentioned components were mixed with purified water 100, onto a tissue paper substrate having a basis weight of 40 g / m ^{2 in} an amount of 0.8% by mass.

(Prescription Example 13) Wet wiping sheet
Ivy extract 0.4
Hop extract 0.8
Ethanol 8.0
Propylene glycol 12.0
Preservative appropriate amount
The liquid preparation mixed with the remaining components as purified water 100 was sprayed uniformly in an amount of 1.4% by mass on 55 g / mm ² gauze to obtain a wet wipe sheet.

It is a figure which shows the trypsin inhibitory effect of a plant extract. It is a figure which shows the trypsin inhibitory effect of a plant extract. It is a figure which shows the trypsin inhibitory effect of a plant extract. It is a figure which shows the trypsin inhibitory effect of a plant extract. It is a figure which shows the trypsin inhibitory effect of a plant extract. It is a figure which shows the trypsin inhibitory effect of a plant extract. It is a figure which shows the trypsin inhibitory effect of a plant extract. It is a figure which shows the trypsin inhibitory effect of a plant extract. It is a figure which shows the trypsin inhibitory effect of a plant extract.

Claims (1)

A trypsin inhibitor comprising a gentian extract.

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