JP5291369B2 - Keratinocyte growth promoter - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a new keratinocyte proliferation promotor having the keratinocyte proliferation-promoting activity capable of being utilized as an active ingredient of a hair-growing agent or hair tonic. <P>SOLUTION: This keratinocyte proliferation promotor composition comprises the keratinocyte proliferation promotor which is an extract of a plant belonging to the genus Alchornea of Euphorbiaceae, as an active ingredient. The keratinocyte proliferation promotor composition may contain one or more keratinocyte proliferation promotors, and one or more medicinally effective components selected from the group consisting of a skin-whitening agent, an antioxidant, an anti-inflammatory agent, a cell activator, a humectant and a peripheral vascular blood flow promotor. The hair-growing agent and hair tonic containing the keratinocyte proliferation promotor as the active ingredient are also provided. <P>COPYRIGHT: (C)2010,JPO&amp;INPIT

Description

  The present invention relates to a keratinocyte proliferation promoter. The product of the present invention is used particularly in the fields of quasi drugs and cosmetics.

The number of people who suffer from thinning hair, hair loss and hair loss has been increasing in recent years due to stress and changes in dietary habits due to changes in the social environment. Moreover, since this tendency is spreading from the middle-aged group to the young group, it is required to clarify the cause and mechanism of thinning hair, hair loss, and hair loss. Recently, many studies have been made on the mechanism of hair growth, but there are still many unclear points. Therefore, a great number of hair restorers containing various herbal medicines and drugs are on the market. For example, a combination of extract extracts (patent document 1, patent document 2) such as Yokuinin, Ginkgo, Kashou, vitamin E, alloxazine, pyridine N-oxide, adenosine-3 ′, 5′-cyclic monophos Fate etc. (Patent Document 3, Patent Document 4, Patent Document 5).

Commercial hair restorers containing these plant extracts and herbal medicines are effective in preventing thinning hair, hair loss, dandruff that contributes to the onset of hair loss, and improvement of itching, and promote hair growth and hair growth. Has been. However, the hair-growth / hair-growth effect varies greatly from person to person, and the fact is that there are almost no remarkable effects. Therefore, development of a new hair restorer that is more effective is required.

The followings are known for Euphorbiaceae alchornea castaneifolia (Euphorbiaceae alchornea floribunnda) or Euphorbiaceae alchornea trewioides, which are Euphorbiaceae alchornea used in the present invention.
In the Amazon, oil from the bark of Ipollu is used as a tincture for rheumatism, arthritis, colds and muscle pain (Non-patent Document 1). In Peru, it is traditionally used for the purpose of relieving the pain of osteoporosis and smoothing the movement (Non-Patent Documents 2 and 3). Even now, it is known that evaluation as a treatment for rheumatism is high (Non-patent Document 4). In addition, it has been reported that malotsinic acid isolated and obtained from an extract of Euphorbiaceae alchornea trewioides has an antioxidant effect (Patent Document 6). However, in these publications, there is no description that the extract of the Euphorbiaceae family plant has a keratinocyte growth promoting action and can be used as a hair growth agent or a hair growth agent containing it as an active ingredient. It is not even taught.

Japanese Patent Publication No. 1-13451 JP-A-2-48514 JP-A 64-56608 JP-A-1-261321 JP-A-2-204406 JP2007-254427 Duke, James and Vasquez, Rudolfo, 1994Amazonian Ethnobotanical Dictionary, CRC Press Inc., Boca Raton, FL Easterling, J. 1993 Traditional Uses of Rainforest Botanicals Powerful and Unusual Herbs from the Amazon and China, 1993.The WorldPreservation Society, Inc. Vasquez M., R. 1990. Useful Plants of Amazonian Peru. Spanish typescript. SecondDraft. Filed with USDA ’s National Agriculture Library.

  An object of the present invention is to provide a novel keratinocyte proliferation promoter having keratinocyte cell proliferation promoting activity which can be used as an active ingredient of a hair growth agent or a hair growth agent.

In order to solve the above-mentioned problems, the present inventors have intensively studied, and as a result, found an extract of Euphorbiaceae Amigasagiri genus plant to promote keratinocyte proliferation and completed the present invention.

  An object of the present invention is to provide a keratinocyte growth promoter that exhibits an excellent hair growth effect and a hair growth effect, and a hair growth agent comprising a keratinocyte growth promoter that exhibits an excellent hair growth effect and a hair growth effect as an active ingredient It is to provide a hair restorer.

  That is, as means for solving the problems of the present invention, there is provided a keratinocyte growth promoter composition containing, as an active ingredient, a keratinocyte growth promoter characterized by being an extract of a Euphorbiaceae plant. , One or more selected from the keratinocyte proliferation promoter of the present invention, and a medicinal effect selected from the group consisting of a whitening agent, an antioxidant, an anti-inflammatory agent, a cell activator, a moisturizer, and a peripheral vascular blood flow promoter It may be a keratinocyte growth promoter composition containing one or more components, and it is to provide a hair growth agent and a hair growth agent containing the keratinocyte growth promoter of the present invention as an active ingredient.

Hereinafter, the present invention will be described in detail.

The present invention is a keratinocyte growth promoter comprising an extract of Euphorbiaceae, which is an active ingredient.

Moreover, this invention is a keratinocyte growth promoter composition containing the following component (A) and (B).
(A) One or more medicinal ingredients selected from the group consisting of keratinocyte growth promoters containing extracts of Euphorbiaceae, which are active ingredients, (B) whitening agents, antioxidants, anti-inflammatory agents, cells One or more medicinal ingredients selected from the group consisting of activators, moisturizers, peripheral blood flow promoters

The Euphorbiaceae plant used in the present invention includes, for example, the Japanese maggot (Euphorbiaceae alchornea liukiuensis), Euphorbiaceae alchornea cordifolia, Euphorbiaceae alchornea villosa
Preferably, it is a plant growing in the foothills of the Amazon or in the riverside of Peru (Euphorbiaceae alchornea castaneifolia), (Euphorbiaceae alchornea floribunnda) It is a growing plant, Euphorbiaceae alchornea trewioides. However, it is not particularly limited to this plant as long as it belongs to the Euphorbiaceae family.

  The site used by Euphorbiaceae, which can be used in the present invention, can be one or more of whole plants or their flowers, leaves, bark, stems, stems, roots, seeds, aerial parts, It is preferable to use bark, leaves or whole grass as the extraction material. Preferably, one or two or more portions (hereinafter referred to as “original”) such as bark, leaves, or the whole grass of each plant are dried, without being dried, after being ground or without being ground, / Or lower alcohols such as methanol, ethanol, propanol or lower alcohol aqueous solutions, polyhydric alcohols such as propylene glycol, 1,3-butylene glycol, glycerin, etc., or polyhydric alcohol aqueous solutions, ketones such as acetone and methyl ethyl ketone, ethyl acetate, etc. Alkyl esters, carbohydrates such as benzene and hexane, ethers such as diethyl ether, halogenated alkanes such as dichloromethane and chloroform, and the like and / or any combination of two or more solvents can be used.

  The extract solution of Euphorbiaceae, which can be used in the present invention, with a lower alcohol is immersed in 1 to 100 times the extraction solvent with respect to the plant base 1, and extracted at warm or normal temperature to obtain an extract solution. It was. Various extracts were concentrated under reduced pressure and then lyophilized to obtain respective extracts.

The compounding amount (content) of various active ingredients that are keratinocyte growth promoters according to the present invention (the extract of the genus Euphorbiaceae) depends on the type and / or combination of the active ingredients, the purpose of use, and the embodiment. Since it can be changed according to the use form, the number of uses, etc., it is not particularly limited. In principle, an effective amount may be present, but the content of various plant extracts is preferably in the range of 0.0001 to 10% by weight (hereinafter simply indicated as “%”) as a solid content, More preferably, it is 0.001 to 5% of range. If it is this range, the effect of this invention will express more notably. If the content is less than 0.0001%, a sufficient effect cannot be exhibited, and the effect is almost constant even when added in an amount of 10% or more. When the extract is used, the concentration of the extract is not limited as long as the content of the dry solid as a solute is within the above range.

  The application range of the cosmetic according to the present invention is not particularly limited. That is, the present invention can be applied to all cosmetics that can use each function and effect according to the function and effect of the active ingredient of the present invention.

In addition to the composition of the present invention, the therapeutic agents and cosmetics containing the keratinocyte growth promoter of the present invention as an active ingredient are components commonly used in pharmaceuticals and cosmetics, such as powder components, liquid fats and oils, solid fats and waxes, and the like. , Hydrocarbon oil, higher fatty acid, ester oil, silicone oil, anionic surfactant, cationic surfactant, amphoteric surfactant, nonionic surfactant, water-soluble polymer, thickener, UV absorber, metal ion Sequestering agents, alcohols, sugars, amino acids, organic amines, polymer emulsions, pH adjusters, vitamins, antioxidants, antioxidant aids, moisturizers, water, whitening agents, anti-inflammatory agents, antibacterial agents, cell activators , Peripheral vascular blood flow promoters, etc., as appropriate, blended as necessary, solution, gel, emulsion, solid, powder, paste, film, aerosol cosmetics, etc. According to shape It can be produced by known methods in general. Specific ingredients that can be blended are listed below, but the therapeutic agent and cosmetics of the present invention can be prepared by blending the composition of the present invention and any one or more of the following components.

  Examples of the powder component include inorganic powders (for example, talc, kaolin, mica, sericite (sericite), muscovite, phlogopite, synthetic mica, saucite, biotite, permiculite, magnesium carbonate, calcium carbonate, silicic acid. Aluminum, barium silicate, calcium silicate, magnesium silicate, strontium silicate, metal tungstate, magnesium, silica, zeolite, barium sulfate, calcined calcium sulfate (baked gypsum), calcium phosphate, fluorine apatite, hydroxyapatite, ceramic powder Metal soap (eg, zinc myristate, calcium palmitate, aluminum stearate), boron nitride, etc .; organic powder (eg, polyamide resin powder (nylon powder), polyethylene powder, polymethyl methacrylate powder, Styrene powder, copolymer resin powder of styrene and acrylic acid, benzoguanamine resin powder, polytetrafluoroethylene powder, cellulose powder, etc.); inorganic white pigment (eg, titanium dioxide, zinc oxide, etc.); inorganic red pigment (eg, , Iron oxide (Bengara), iron titanate, etc.); inorganic brown pigment (for example, γ-iron oxide, etc.); inorganic yellow pigment (for example, yellow iron oxide, loess); inorganic black pigment (for example, black) Iron oxide, low-order titanium oxide, etc.); inorganic purple pigments (eg, manganese violet, cobalt violet, etc.); inorganic green pigments (eg, chromium oxide, chromium hydroxide, cobalt titanate, etc.); inorganic blue pigments (eg, For example, ultramarine blue, bitumen, etc.); pearl pigments (eg, titanium oxide coated mica, titanium oxide coated bismuth oxychloride, titanium oxide coated titanium) Lac, colored titanium oxide coated mica, bismuth oxychloride, fish scale foil, etc.); metal powder pigments (eg, aluminum powder, copper powder, etc.); organic pigments such as zirconium, barium, or aluminum lake (eg, red 201, red 202) No., Red 204, Red 205, Red 220, Red 226, Red 228, Red 405, Orange 203, Orange 204, Yellow 205, Yellow 401, and Blue 404 Red No. 3, Red No. 104, Red No. 106, Red No. 227, Red No. 230, Red No. 401, Red No. 505, Orange No. 205, Yellow No. 4, Yellow No. 5, Yellow No. 202, Yellow No. 203, Green No. 3 and Blue No. 1); natural pigments (for example, chlorophyll, β-carotene, etc.) and the like.

  Examples of liquid oils include avocado oil, camellia oil, turtle oil, macadamia nut oil, corn oil, mink oil, olive oil, rapeseed oil, egg yolk oil, sesame oil, persic oil, wheat germ oil, southern castor oil, castor oil, linseed oil , Safflower oil, cottonseed oil, eno oil, soybean oil, peanut oil, tea seed oil, kaya oil, rice bran oil, cinnagiri oil, Japanese kiri oil, jojoba oil, germ oil, triglycerin and the like.

  Examples of the solid fat include cacao butter, coconut oil, hardened coconut oil, palm oil, palm kernel oil, owl kernel oil, hardened oil, owl, and hardened castor oil.

  Examples of the wax include beeswax, candelilla wax, cotton wax, carnauba wax, bayberry wax, ibota wax, whale wax, montan wax, nuka wax, lanolin, kapok wax, lanolin acetate, liquid lanolin, sugar cane wax, lanolin fatty acid isopropyl, hexyl laurate, reduced lanolin, Examples include jojoba wax, hard lanolin, shellac wax, POE lanolin alcohol ether, POE lanolin alcohol acetate, POE cholesterol ether, lanolin fatty acid polyethylene glycol, and POE hydrogenated lanolin alcohol ether.

  Examples of the hydrocarbon oil include liquid paraffin, ozokerite, squalane, pristane, paraffin, ceresin, squalene, petrolatum, microcrystalline wax, and the like.

  Examples of higher fatty acids include lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, undecylenic acid, tall oil fatty acid, isostearic acid, linoleic acid, linolenic acid, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) etc. are mentioned.

  Examples of ester oils include isopropyl myristate, cetyl octanoate, octyldodecyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, decyl oleate, hexyl decyl dimethyloctanoate, cetyl lactate, lactic acid Myristyl, lanolin acetate, isocetyl stearate, isocetyl isostearate, cholesteryl 12-hydroxystearate, ethylene glycol di-2-ethylhexanoate, dipentaerythritol fatty acid ester, monoisostearate N-alkyl glycol, neopentyl glycol dicaprate, Diisostearyl malate, glycerin di-2-heptylundecanoate, trimethylolpropane tri-2-ethylhexanoate, triiso Trimethylolpropane teaate, pentaerythritol tetra-2-ethylhexanoate, glycerin tri-2-ethylhexanoate, glyceryl trioctanoate, glyceryl triisopalmitate, trimethylolpropane triisostearate, cetyl 2-ethylhexanoate, 2-ethylhexyl palmitate, glyceryl trimyristate, tri-2-heptylundecanoic acid glyceride, castor oil fatty acid methyl ester, oleyl oleate, acetoglyceride, 2-heptylundecyl palmitate, diisobutyl adipate, N-lauroyl-L -Glutamic acid-2-octyldodecyl ester, di-2-heptylundecyl adipate, ethyl laurate, di-2-ethylhexyl sebacate, 2-hexyl myristate Rudeshiru, palmitic acid 2-hexyl decyl, 2-hexyldecyl adipate, diisopropyl sebacate, 2-ethylhexyl succinate, and triethyl citrate.

  Examples of the silicone oil include linear polysiloxanes (for example, dimethylpolysiloxane, methylphenylpolysiloxane, diphenylpolysiloxane, etc.); cyclic polysiloxanes (for example, octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexyl). And silicone resins that form a three-dimensional network structure, various modified polysiloxanes (amino-modified polysiloxane, polyether-modified polysiloxane, alkyl-modified polysiloxane, fluorine-modified polysiloxane, etc.) It is done.

  Anionic surfactants include, for example, fatty acid soaps (eg, sodium laurate, sodium palmitate, etc.); higher alkyl sulfates (eg, sodium lauryl sulfate, potassium lauryl sulfate, etc.); alkyl ether sulfates (eg, POE-lauryl sulfate triethanolamine, POE-sodium lauryl sulfate, etc.); N-acyl sarcosine acid (eg, sodium lauroyl sarcosine, etc.); higher fatty acid amide sulfonates (eg, sodium N-myristoyl-N-methyl taurate, palm Oil fatty acid methyl taurine sodium, lauryl methyl taurine sodium, etc .; Phosphate ester salt (POE-oleyl ether sodium phosphate, POE-stearyl ether phosphate, etc.); Sulfosuccinate (for example, Sodium di-2-ethylhexyl sulfosuccinate, sodium monolauroyl monoethanolamide polyoxyethylene sodium sulfosuccinate, sodium lauryl polypropylene glycol sulfosuccinate, etc .; alkyl benzene sulfonates (eg, sodium linear dodecyl benzene sulfonate, triso linear dodecyl benzene sulfonate) Ethanolamine, linear dodecyl benzene sulfonic acid, etc.); higher fatty acid ester sulfates (for example, hydrogenated coconut oil fatty acid sodium glycerin sulfate, etc.); N-acyl glutamate (for example, monosodium N-lauroyl glutamate, di-N-stearoyl glutamate) Sodium, N-myristoyl-L-monosodium glutamate, etc.); sulfated oil (eg funnel oil); POE-A Kill ether carboxylic acid; POE-alkyl allyl ether carboxylate; α-olefin sulfonate; higher fatty acid ester sulfonate; secondary alcohol sulfate ester; higher fatty acid alkylolamide sulfate ester; lauroyl monoethanolamide succinic acid Sodium; N-palmitoyl aspartate ditriethanolamine; sodium caseinate and the like.

  Examples of the cationic surfactant include alkyltrimethylammonium salts (eg, stearyltrimethylammonium chloride, lauryltrimethylammonium chloride, etc.); alkylpyridinium salts (eg, cetylpyridinium chloride, etc.); distearyldimethylammonium dialkyldimethylammonium chloride; Poly (N, N′-dimethyl-3,5-methylenepiperidinium chloride); alkyl quaternary ammonium salt; alkyldimethylbenzylammonium salt; alkylisoquinolinium salt; dialkyl morpholinium salt; POE-alkylamine; Examples include alkylamine salts; polyamine fatty acid derivatives; amyl alcohol fatty acid derivatives; benzalkonium chloride; benzethonium chloride and the like.

  Examples of amphoteric surfactants include imidazoline-based amphoteric surfactants (eg, 2-undecyl-N, N, N- (hydroxyethylcarboxymethyl) -2-imidazoline sodium, 2-cocoyl-2-imidazolinium hydroxide). Side-1-carboxyethyloxy disodium salt, etc.); betaine surfactants (for example, 2-heptadecyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, lauryldimethylaminoacetic acid betaine, alkylbetaine, amide betaine) , Sulfobetaine, etc.).

  Examples of the lipophilic nonionic surfactant include sorbitan fatty acid esters (for example, sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, Sorbitan trioleate, diglycerol sorbitan penta-2-ethylhexylate, diglycerol sorbitan tetra-2-ethylhexyl); glycerin polyglycerin fatty acids (for example, mono-cotton oil fatty acid glycerin, mono-erucic acid glycerin, sesquioleate glycerin, monostearin) Glycerin acid, α, α′-oleic acid pyroglutamate glycerin, monostearate glycerin malate, etc.); propylene glycol fatty acid esters (for example, And propylene glycol monostearate); hardened castor oil derivatives; glycerin alkyl ethers and the like.

  Examples of the hydrophilic nonionic surfactant include POE-sorbitan fatty acid esters (for example, POE-sorbitan monooleate, POE-sorbitan monostearate, POE-sorbitan monooleate, POE-sorbitan tetraoleate, etc.); POE sorbite fatty acid esters (eg, POE-sorbite monolaurate, POE-sorbite monooleate, POE-sorbite pentaoleate, POE-sorbite monostearate, etc.); POE-glycerin fatty acid esters (eg, POE-glycerin) Monostearate, POE-glycerol monoisostearate, POE-monooleate such as POE-glycerol triisostearate, etc.); POE-fatty acid esters (eg, POE-distearate, PO Monodiolates, ethylene glycol distearate, etc.); POE-alkyl ethers (eg POE-lauryl ether, POE-oleyl ether, POE-stearyl ether, POE-behenyl ether, POE-2-octyldecyl ether, POE-cholestanol) Ethers, etc.); Pluronic types (for example, Pluronic etc.); POE • POP-alkyl ethers (for example, POE • POP-cetyl ether, POE • POP-2-decyltetradecyl ether, POE • POP-monobutyl ether, POE) POP-hydrogenated lanolin, POE / POP-glycerin ether, etc.); Tetra POE / tetra-POP-ethylenediamine condensates (eg, Tetronic, etc.); POE-castor oil hardened castor oil derivative ( For example, POE-castor oil, POE-hardened castor oil, POE-hardened castor oil monoisostearate, POE-hardened castor oil triisostearate, POE-hardened castor oil monopyroglutamic acid monoisostearic acid diester, POE-hardened castor Oil maleic acid, etc.); POE-beeswax lanolin derivatives (eg POE-sorbite beeswax etc.); alkanolamides (eg coconut oil fatty acid diethanolamide, lauric acid monoethanolamide, fatty acid isopropanolamide etc.); POE-propylene glycol fatty acid Examples include esters; POE-alkylamines; POE-fatty acid amides; sucrose fatty acid esters; alkyl ethoxydimethylamine oxides;

  Examples of natural water-soluble polymers include plant-based polymers (for example, gum arabic, tragacanth gum, galactan, guar gum, carob gum, caraya gum, carrageenan, pectin, agar, quince seed (malmello), alge colloid (guckweed extract), starch (Rice, corn, potato, wheat), glycyrrhizic acid); microbial polymers (eg, xanthan gum, dextran, succinoglucan, bullulan, etc.); animal polymers (eg, collagen, casein, albumin, gelatin, etc.), etc. Is mentioned.

  Semi-synthetic water-soluble polymers include, for example, starch polymers (eg, carboxymethyl starch, methylhydroxypropyl starch, etc.); cellulose polymers (methylcellulose, ethylcellulose, methylhydroxypropylcellulose, hydroxyethylcellulose, sodium cellulose sulfate) Hydroxypropylcellulose, carboxymethylcellulose, sodium carboxymethylcellulose, crystalline cellulose, cellulose powder and the like); alginic acid polymers (for example, sodium alginate, propylene glycol alginate, etc.) and the like.

  Synthetic water-soluble polymers include, for example, vinyl polymers (eg, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, carboxyvinyl polymer); polyoxyethylene polymers (eg, polyethylene glycol 20,000, 40). , 000, 60,000 polyoxyethylene polyoxypropylene copolymer, etc.); acrylic polymers (for example, sodium polyacrylate, polyethyl acrylate, polyacrylamide, etc.); polyethyleneimine; cationic polymers, and the like.

  Examples of the thickener include gum arabic, carrageenan, caraya gum, gum tragacanth, carob gum, quince seed (malmello), casein, dextrin, gelatin, sodium pectate, sodium alginate, methylcellulose, ethylcellulose, CMC, hydroxyethylcellulose, hydroxypropyl Cellulose, PVA, PVM, PVP, sodium polyacrylate, carboxyvinyl polymer, locust bean gum, guar gum, tamarind gum, cellulose dialkyldimethylammonium sulfate, xanthan gum, magnesium aluminum silicate, bentonite, hectorite, AlMg silicate (Beegum), Examples thereof include laponite and silicic anhydride.

Examples of the ultraviolet absorber include the following compounds.
(1) Benzoic acid-based ultraviolet absorbers such as paraaminobenzoic acid (hereinafter abbreviated as PABA), PABA monoglycerin ester, N, N-dipropoxy PABA ethyl ester, N, N-diethoxy PABA ethyl ester, N, N-dimethyl PABA ethyl ester, N, N-dimethyl PABA butyl ester, N, N-dimethyl PABA ethyl ester and the like.
(2) Anthranilic acid-based UV absorbers such as homomenthyl-N-acetylanthranilate.
(3) Salicylic acid ultraviolet absorbers such as amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p-isopropanol phenyl salicylate and the like.
(4) Cinnamic acid ultraviolet absorbers such as octyl cinnamate, ethyl-4-isopropyl cinnamate, methyl-2,5-diisopropyl cinnamate, ethyl-2,4-diisopropyl cinnamate, methyl-2,4- Diisopropyl cinnamate, propyl-p-methoxycinnamate, isopropyl-p-methoxycinnamate, isoamyl-p-methoxycinnamate, octyl-p-methoxycinnamate (2-ethylhexyl-p-methoxycinnamate), 2-ethoxy Ethyl-p-methoxycinnamate, cyclohexyl-p-methoxycinnamate, ethyl-α-cyano-β-phenylcinnamate, 2-ethylhexyl-α-cyano-β-phenylcinnamate, glyceryl mono-2-ethylhexanoyl -Diparamet Such as Shishin'nameto.
(5) Triazine-based ultraviolet absorbers such as bisresorcinyl triazine.
More specifically, bis {[4- (2-ethylhexyloxy) -2-hydroxy] phenyl} -6- (4-methoxyphenyl) 1,3,5-triazine, 2,4,6-tris { 4- (2-ethylhexyloxycarbonyl) anilino} 1,3,5-triazine and the like.
(6) Other ultraviolet absorbers such as 3- (4′-methylbenzylidene) -d, l-camphor, 3-benzylidene-d, l-camphor, 2-phenyl-5-methylbenzoxazole, 2,2 '-Hydroxy-5-methylphenylbenzotriazole, 2- (2'-hydroxy-5'-t-octylphenyl) benzotriazole, 2- (2'-hydroxy-5'-methylphenylbenzotriazole), dibenzalazine, dianisoyl Pyridazine derivatives such as methane, 4-methoxy-4′-t-butyldibenzoylmethane, 5- (3,3-dimethyl-2-norbornylidene) -3-pentan-2-one, dimorpholinopyridazinone and the like.

  Examples of the sequestering agent include 1-hydroxyethane-1,1-diphosphonic acid, 1-hydroxyethane-1,1-diphosphonic acid tetrasodium salt, disodium edetate, trisodium edetate, and tetrasodium edetate. Sodium citrate, sodium polyphosphate, sodium metaphosphate, gluconic acid, phosphoric acid, citric acid, ascorbic acid, succinic acid, edetic acid, trisodium ethylenediaminehydroxyethyl triacetate and the like.

  Examples of the lower alcohol include ethanol, propanol, isopropanol, isobutyl alcohol, t-butyl alcohol and the like.

  Examples of the polyhydric alcohol include divalent alcohols (for example, ethylene glycol, propylene glycol, trimethylene glycol, 1,2-butylene glycol, 1,3-butylene glycol, tetramethylene glycol, 2,3-butylene glycol, Pentamethylene glycol, 2-butene-1,4-diol, hexylene glycol, octylene glycol, etc.); trivalent alcohol (eg, glycerin, trimethylolpropane, etc.); tetravalent alcohol (eg, 1, 2, 6) Pentaerythritol such as hexanetriol, etc .; pentavalent alcohol (eg, xylitol, etc.); hexavalent alcohol (eg, sorbitol, mannitol, etc.); polyhydric alcohol polymer (eg, diethylene glycol, dipropylene glycol, Tylene glycol, polypropylene glycol, tetraethylene glycol, diglycerin, polyethylene glycol, triglycerin, tetraglycerin, polyglycerin, etc.); divalent alcohol alkyl ethers (for example, ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol) Monobutyl ether, ethylene glycol monophenyl ether, ethylene glycol monohexyl ether, ethylene glycol mono 2-methylhexyl ether, ethylene glycol isoamyl ether, ethylene glycol benzyl ether, ethylene glycol isopropyl ether, ethylene glycol dimethyl ether, ethylene glycol diethyl ether, ethylene glycol Dibutyl Dihydric alcohol alkyl ethers (for example, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol monobutyl ether, diethylene glycol dimethyl ether, diethylene glycol diethyl ether, diethylene glycol butyl ether, diethylene glycol methyl ethyl ether, triethylene glycol monomethyl ether, triethylene glycol) Monoethyl ether, propylene glycol monomethyl ether, propylene glycol monoethyl ether, propylene glycol monobutyl ether, propylene glycol isopropyl ether, dipropylene glycol methyl ether, dipropylene glycol ethyl ether, dipropylene glycol Dibutyl alcohol ether ester (for example, ethylene glycol monomethyl ether acetate, ethylene glycol monoethyl ether acetate, ethylene glycol monobutyl ether acetate, ethylene glycol monophenyl ether acetate, ethylene glycol diazebate, ethylene glycol disuccine) , Diethylene glycol monoethyl ether acetate, diethylene glycol monobutyl ether acetate, propylene glycol monomethyl ether acetate, propylene glycol monoethyl ether acetate, propylene glycol monopropyl ether acetate, propylene glycol monophenyl ether acetate, etc.); glycerin monoalkyl ether (example) Sugar alcohol (eg, sorbitol, maltitol, maltotriose, mannitol, sucrose, erythritol, glucose, fructose, starch-degrading sugar, maltose, xylitol, starch degradation) Sugar-reduced alcohol, etc.); Glysolid; Tetrahydrofurfuryl alcohol; POE-Tetrahydrofurfuryl alcohol; POP-Butyl ether; POP / POE-Butyl ether; Tripolyoxypropylene glycerin ether; POP-glycerin ether; POP-glycerin ether phosphate POP · POE-pentane erythritol ether, polyglycerin and the like.

  Examples of higher alcohols include linear alcohols (eg, lauryl alcohol, cetyl alcohol, stearyl alcohol, behenyl alcohol, myristyl alcohol, oleyl alcohol, cetostearyl alcohol); branched chain alcohols (eg, monostearyl glycerin ether (batyl alcohol) ), 2-decyltetradecinol, lanolin alcohol, cholesterol, phytosterol, hexyldodecanol, isostearyl alcohol, octyldodecanol and the like.

  Examples of monosaccharides include tricarbon sugars (eg, D-glyceryl aldehyde, dihydroxyacetone, etc.); tetracarbon sugars (eg, D-erythrose, D-erythrulose, D-treose, erythritol, etc.); pentose sugars (eg, L-arabinose, D-xylose, L-lyxose, D-arabinose, D-ribose, D-ribulose, D-xylulose, L-xylulose, etc .; hexose (eg, D-glucose, D-talose, D) -Bucicose, D-galactose, D-fructose, L-galactose, L-mannose, D-tagatose, etc.); pentose sugar (eg, aldheptose, heproose, etc.); octose sugar (eg, octulose, etc.); For example, 2-deoxy-D-ribose, 6-deoxy-L-galactose, 6-deoxy-L Mannose, etc.]; amino sugars (eg, D-glucosamine, D-galactosamine, sialic acid, aminouronic acid, muramic acid, etc.); uronic acids (eg, D-glucuronic acid, D-mannuronic acid, L-guluronic acid, D- Galacturonic acid, L-iduronic acid, etc.).

  Examples of the oligosaccharide include sucrose, umbelliferose, lactose, planteose, isolicnose, α, α-trehalose, raffinose, lycnose, umbilicin, stachyose verbus course, and the like.

  Examples of the polysaccharide include cellulose, quince seed, chondroitin sulfate, starch, galactan, dermatan sulfate, glycogen, gum arabic, heparan sulfate, hyaluronic acid, tragacanth gum, keratan sulfate, chondroitin, xanthan gum, mucoitin sulfate, guar gum, dextran, kerato sulfate. , Locust bingham, succinoglucan, caronic acid and the like.

  Examples of amino acids include neutral amino acids (eg, threonine, cysteine, etc.); basic amino acids (eg, hydroxylysine, etc.) and the like. Examples of the amino acid derivative include acyl sarcosine sodium (lauroyl sarcosine sodium), acyl glutamate, acyl β-alanine sodium, glutathione, and pyrrolidone carboxylic acid.

  Examples of the organic amine include monoethanolamine, diethanolamine, triethanolamine, morpholine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-methyl-1-propanol, and the like. Is mentioned.

  Examples of the polymer emulsion include an acrylic resin emulsion, a polyethyl acrylate emulsion, an acrylic resin liquid, a polyacryl alkyl ester emulsion, a polyvinyl acetate resin emulsion, and a natural rubber latex.

  Examples of the pH adjusting agent include buffers such as lactic acid-sodium lactate, citric acid-sodium citrate, and succinic acid-sodium succinate.

  Examples of vitamins include vitamin A, B1, B2, B6, C, E and derivatives thereof, pantothenic acid and derivatives thereof, biotin and the like.

  Examples of the antioxidant include vitamin E and derivatives thereof (dl-α (β, γ) -tocopherol, dl-α-tocopherol acetate, nicotinic acid-dl-α-tocopherol, linoleic acid-dl-α-tocopherol, Tocopherols such as dl-α-tocopherol succinate and derivatives thereof, ubiquinones, etc., vitamin A and derivatives thereof (retinol palmitate, retinol acetate such as retinol and derivatives thereof, retinal such as dehydroretinal and derivatives thereof), carotenoids (Carotene, lycopene, astaxanthin, etc.), vitamin B and its derivatives (thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxine hydrochloride, pyridoxine dioctanoate, flavin adenine dinucleotide, cyanocobalamin, Acids, nicotinic acid amides, nicotinic acids such as benzyl nicotinate, cholines, etc.), vitamin C and derivatives thereof (L-ascorbic acid alkyl esters such as L-ascorbyl dipalmitate and L-ascorbyl tetraisopalmitate, L- Ascorbic acid phosphate, L-ascorbic acid sulfate, etc.), vitamin D and its derivatives (ergocalciferol, cholecalciferol, dihydroxystannal etc.), rutin and its derivatives, thiotaurine, taurine, hydroquinone and its derivatives, histidine Catechins and derivatives thereof, grabrizine, glabrene, liquiritin, isoliquiritin and licorice extract containing these, glutathione and derivatives thereof, dibutylhydroxytoluene, butylhydroxyanisole , Gallic acid and its derivatives, cholesterol and its derivatives, superoxide dismutase, mannitol, cucumber extract, quette extract, gentian (gentian) extract, genus shochu extract, hawthorn extract, peonies extract, ginkgo biloba extract, koganebana (Ougon) extract, carrot extract, maika (maikai, hermanus) extract, sunpens (kawara ketsumei) extract, tormentilla extract, parsley extract, grape extract, button (button pi) extract, mokka (bokeh) extract , Melissa extract, Yashajitsu (Yasha) extract, Yukinoshita extract, Rosemary (mannenrou) extract, lettuce extract, tea extract (Oolong tea, black tea, green tea, etc.), microbial fermentation metabolites, seaweed extract, Ganoderma extract, eggshell membrane extract, fetus Extracts include swingle extract or the like. (In parentheses, plant aliases and herbal medicine names are listed.)

Examples of the antioxidant assistant include phosphoric acid, citric acid, ascorbic acid, maleic acid, malonic acid, succinic acid, fumaric acid, kephalin, hexametaphosphate, phytic acid, and ethylenediaminetetraacetic acid.

Examples of humectants include polyethylene glycol, propylene glycol, glycerin, 1,3-butylene glycol, xylitol, sorbitol, maltitol, chondroitin sulfate, hyaluronic acid, mucoitin sulfate, caronic acid, atelocollagen, cholesteryl-12-hydroxystearate, and lactic acid. Examples thereof include sodium, bile salt, dl-pyrrolidone carboxylate, short-chain soluble collagen, diglycerin (EO) PO adduct, Izayoi rose extract, yarrow extract, merirot extract, purple root extract and the like.

Examples of whitening agents include resorcin, vitamin C and derivatives thereof (L-ascorbic acid alkyl esters such as L-ascorbyl dipalmitate, L-ascorbyl tetraisopalmitate, L-ascorbic acid phosphate, L-ascorbic acid sulfate). Etc.), placenta extract, glabrizine, glabrene, liquiritin, isoliquiritin and licorice extract, yokoinin extract, oganone extract, seaweed extract (comb, macombu, wakame, hijiki, hibamata) , Sugime, Trollocombu, Kajime, Tsuruarame, Chigaiso, Honda Rawa, Giant Kelp and other brown algae; Proboscis, Tsunomata, Sugiori, Usubanori, Asakusanori, Matsunori, Tosakamatsu, Funori, Ogonori, Kamensou, Igisu, Red algae such as Gonori; green algae such as Chlorella, Aonori, Donariella, Chlorococcus, Anaaaosa, Kawanori, Marimo, Shiogusa, Casanori, Futojusmo, Tamajusmo, Aeguro, Ao-Midro, etc .; , Grape extract, wheat extract, tomato extract, carotenoid (carotene, lycopene, astaxanthin, etc.), agarose, oligosaccharide, neoagarobiose, hydroquinone and its derivatives, cysteine and its derivatives, asparagus extract, Ibuki Toranoo extract, Neubara (agetsu) extract, Ezokogi extract, pea extract, chamomile extract, bayberry extract, orange extract, raspberry extract, kiwi extract, Clara extract, coffee Extract, Sesame oil, Sesame oil, Sesame extract, Rice extract, Rice bran extract, Saisin extract, Hawthorn extract, Sunpens extract, Peonies extract, Shirayuri extract, Mulberry extract Beech extract, beech sprout extract, black currant extract, hop extract, maika (maikai, hamanasu) extract, mokka (bokeh) extract, yukinoshita extract, tea extract (Oolong tea, black tea, green tea, etc.) , Reishi extract, microbial fermentation metabolite, soybean extract, molasses extract, rahan fruit extract, dokudami extract and the like. (In parentheses, plant aliases and herbal medicine names are listed.)

  Anti-inflammatory agents include glycyrrhizic acid and its derivatives, glycyrrhetinic acid and its derivatives, vitamin B and its derivatives (thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxine hydrochloride, pyridoxine dioctanoate, flavin adenine dinucleotide , Nicotinic acid such as cyanocobalamin, folic acid, nicotinic acid amide, benzyl nicotinate, choline, tranexamic acid, thiotaurine, hypotaurine, aloe extract, ashitaba extract, altea extract, arnica extract, sulfur and its derivatives, toki Extract, nettle extract, ginseng extract, turmeric extract, yellowfin extract, hypericum extract, chamomile extract, comfrey extract, honeysuckle (goldfish) ) Extract, Watercress extract, Salvia (sage) extract, Walnut extract (Jiuyu) extract, Perilla extract, Birch extract, Elderberry extract, Grape extract, Mucurodi extract, Eucalyptus extract, Artemisia extract Examples include extracts, Astragalus extract, chondroitin sulfate and derivatives thereof, zinc oxide, etc. (In parentheses, plant aliases, herbal medicine names, etc. are described.)

  Examples of cell activators include carotenoids (such as carotene, lycopene, astaxanthin), vitamin A and derivatives thereof (retinol such as retinol palmitate and retinol acetate; and retinals such as dehydroretinal and derivatives thereof), vitamin C and its derivatives. Derivatives (L-ascorbic acid alkyl esters such as L-ascorbyl dipalmitate and L-ascorbyl tetraisopalmitate, L-ascorbic acid phosphate, L-ascorbic acid sulfate, etc.), vitamin B and its derivatives (thiamine hydrochloride) Salt, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxine hydrochloride, pyridoxine dioctanoate, flavin adenine dinucleotide, cyanocobalamin, folic acid, nicotinamide and benzyl nicotinate (Tinic acids, choline, etc.), ribonucleic acid and salts thereof, deoxyribonucleic acid and salts thereof, α- and γ-linolenic acid, xanthine and derivatives thereof (caffeine, etc.), amino acids and derivatives thereof (serine, glutamic acid, theanine, hydroxy) Proline, pyrrolidone carboxylic acid, etc.), docosahexaenoic acid and its derivatives, eicosapentaenoic acid and its derivatives, citric acid, lactic acid, malic acid, succinic acid, almond extract, asparagus extract, apricot extract, ginkgo biloba extract , Kihada extract, barley extract, kiwi extract, cucumber extract, shiitake extract, cedar extract, assembly extract, soybean extract, jujube extract, clover extract , Pepper extract, red pepper extract, tomato extract, Garlic extract, carrot extract, hinokitiol, beech extract, grape seed oil, beech extract, beech bud extract, peach extract, eucalyptus extract, lily extract, lettuce extract, lemon extract, rosemary (Mannenrou) extract, malt root extract, animal-derived extract (mollusk and other mollusc extracts, shell extract, shellfish extract, fish extract, chicken crown extract, royal jelly, silk protein and its degradation product, placenta Extract, serum deproteinized extract, lactoferrin or degradation product thereof), yeast extract, microbial fermentation metabolite (derived from lactic acid bacteria, bifidobacteria, etc.), ganoderma extract, sesame extract and the like. (In parentheses, plant aliases and herbal medicine names are listed.)

  Examples of peripheral vascular blood flow promoters include vitamin E and its derivatives, assembly extract, garlic extract, ginger extract, red pepper extract, rosemary extract, and dio extract.

  The composition of the present invention and one or more of the above components can be combined to provide a multifunctional cosmetic.

EXAMPLES Hereinafter, although this invention is demonstrated in detail based on an Example, this invention is not limited to these Examples.

Example 1
[Preparation example of plant extract]
(1) 5 g of a powder obtained by mixing 4 g of an extract obtained by extracting the whole plant containing the bark and leaves of iporul (Euphorbiaceae alchornea castaneifolia or Euphorbiaceae alchornea floribunnda) with hot water and 1 g of dextrin. Add 100 g of 50 vol% ethanol. Next, after extracting by heating at 60 ° C. for 8 hours, an extract of iporul was obtained by filtration. At this time, the dry solid content was 2.53% by weight. This solution was diluted to adjust the concentration, and the following experiment was performed using this solution.
(2) Add 100 g of ethanol with a water content of 50% by volume to 5 g of an extract obtained by extracting the whole plant including bark and leaves of Euphorbiaceae alchornea trewioides with hot water and extracting it with hot water. Next, after extracting by heating at 60 ° C. for 8 hours, an extract of Oobabenigawa was obtained by filtration. At this time, the dry solid content was 1.58% by weight. This solution was diluted to adjust the concentration, and the following experiment was performed using this solution.
(3) Add 100 g of ethanol with a water content of 50% by volume to 5 g of an extract obtained by extracting leaves of dried Euglebiaceae alchornea liukiuensis with hot water. Next, after performing heat extraction at 60 ° C. for 8 hours, filtration was carried out to obtain an extract of a chisel. At this time, the dry solid content was 1.02% by weight. This solution was diluted to adjust the concentration, and the following experiment was performed using this solution.
(4) A carrot extract was used as a representative antioxidant. Its production method is Panax ginseng Panax
ginseng C.I. A. 100 g of ethanol with a water content of 50% by volume is added to 5 g of Meyet. Next, heat extraction was performed at 60 ° C. for 8 hours, followed by filtration to obtain a carrot extract. At this time, the dry solid content was 1.24% by weight. This solution was diluted to adjust the concentration, and the following experiment was performed using this solution.
(5) As a representative of the whitening agent, the following experiment was conducted using resorcin (Wako reagent special grade).
(6) As a representative anti-inflammatory agent, an extract of Toki root was used. “Touki: Toki” means adding 100 g of ethanol with a water content of 50% by volume to 5 g of rhizome / root bark of Umbelliferae and Angelica plant toki (Angelica acutiloba Kitagawa or other related plants). . Next, after performing heat extraction at 60 ° C. for 8 hours, filtration was performed to obtain a root extract of Japanese cypress. At this time, the dry solid content was 1.61% by weight. This solution was diluted to adjust the concentration, and the following experiment was performed using this solution.
(7) As a representative cell activator, an extract of sesame flower was used. The production method is to add 100 g of ethanol with a water content of 50% by volume to 5 g of dried sesame (Sesamum indicum) flowers. Next, after performing heat extraction at 60 ° C. for 8 hours, filtration was performed to obtain an extract of sesame flowers. At this time, the dry solid content was 1.40% by weight. This solution was diluted to adjust the concentration, and the following experiment was performed using this solution.
(8) As a typical humectant, an extract of purple root was used. In the production method, 100 g of ethanol having a water content of 50 vol% is added to 5 g of dried roots of Murasaki, a perennial herb of the family Murasaki. Next, after performing heat extraction at 60 ° C. for 8 hours, the purple root extract was obtained by filtration. At this time, the dry solid content was 2.03% by weight. This solution was diluted to adjust the concentration, and the following experiment was performed using this solution.
(9) As an example of a peripheral blood flow promoting agent, an extract of radish root was used. 100 g of ethanol with a water content of 50% by volume is added to 5 g of dried and finely crushed rhizomes of Rehmannia chinensis. Next, after performing heat extraction at 60 ° C. for 8 hours, filtration was performed to obtain an extract of radish root. At this time, the dry solid content was 2.77% by weight. This solution was diluted to adjust the concentration, and the following experiment was performed using this solution.

[Evaluation Test 1]
1. Cell proliferation test
Normal epidermal keratinocytes (Cambrex) dispersed in Eplife-KG2 (Kurabo) at a concentration of 11 × 10 ⁴ cells / mL in a 24 Well Cell Culture Cluster (CORNING Incorporated)
Corporation) was seeded with 0.5 mL each at n = 3.
After culturing in a CO ₂ incubator at 37 ° C for 24 hours, change the medium to Eplife-KG2 that does not contain growth factors (hydrocortisone, insulin, hEGF, BPE) so that the final concentration of each sample becomes the concentration shown in Table 1. The sample was added to. 144 hours after sample addition, WS-T assay was performed using Cell Counting Kit (Dojindo) to measure cell proliferation rate (%).
The results are shown in Table 1.

[Comparative Example 1]
The co-culture evaluation was performed in the same manner as in Example 1 except that ethanol was used instead of the test substance. The results are shown in Table 1.

  It was found that the extract of Ipollu, the extract of Oobabenigawa, and the extract of Japanese bittern promoted the growth of keratinocytes. It was also observed that the combination of the extract of iporul and carrot extract, resorcinol, toki root, sesame flower and purple root extract also promotes keratinocyte growth.

[Evaluation Test 2]
Next, the results of tests conducted to demonstrate how the hair growth agent of the present invention is excellent in terms of hair growth and hair growth effects are shown.

2. Human hair growth / growth evaluation test An evaluation test was conducted on the effect of actually using the hair growth agent formulated with the product of the present invention.
(1) Sample Product blended product of the present invention: Comparative hair tonic product of Production Example 1 described in Table 3 below: Ipollu extract was removed from the hair tonic of the product blended according to the present invention described in Table 3 below (increased water) Things (2) Test method The test was conducted by dividing 20 panelists (35 to 55 years old) complaining of hirsutism and alopecia into two groups, and applying each sample to the head evenly in the morning and night. . A questionnaire survey confirmed the actual usage of panelists who had been using the camera for 3 months. The evaluation is made in the 3rd month after the start of use. “Reduction of hair loss”, “Improvement of appearance”, “Delay of hair removal rate”, “Thickness of hair”, “Stiff hair”, “Improvement of gray hair” ”,” Reduction of hair loss ”, and the percentage of panelists who answered“ It was effective to some extent ”or“ It was very effective ”as a percentage It is shown in Table 2. In addition, we asked the panelists how much the improvement effect was felt for “the appearance of the hairline”, “the appearance of the top of the head”, and “the overall appearance”. Table 2 shows the percentage of panelists who answered “very satisfied”.

As is apparent from the results of [Table 2], in the group to which the hair restorer containing the extract of iporul of the present invention was applied, all of the panelists who felt the hair growth effect or felt satisfaction with the improvement in appearance. Since the proportion increased, the hair-growth effect was clearly recognized in humans. Furthermore, no skin damage such as deterioration of the scalp or inflammatory reaction was observed in any of the panelists during the study period, and the panel should be sufficiently safe for long-term continuous use. Was also confirmed.

  Hereinafter, blending examples of various dosage forms and a hair restorer containing an extract of iporul according to the present invention will be described as examples.

Using the blending components and blending ratios shown in the hair tonic [Table 3], the hair tonics of the comparative product and the product of the present invention were prepared by mixing sequentially. In addition, a mixture ratio is weight%.

[Production Example 1] Hair shampoo compounding ingredients Compounding amount (wt%)
(A) Lauric acid diethanolamide 5.0
Propylene glycol 5.0
Alkyltrimethylammonium chloride 0.2
Glycerin 0.2
1-menthol 0.1
Ipollu whole plant extract 1.0
(B) Trichlorocarbanilide 0.2
Purified water 88.2
(C) Fragrance 0.1
(Manufacturing method)
The component (A) was heated and mixed at 80 ° C. and cooled, the component (B) was added, and then the component (C) was added to prepare a hair shampoo.

[Production Example 2] Hair rinse compounding component Compounding amount (wt%)
(A) Liquid paraffin 10.0
Alkyltrimethylammonium chloride 0.2
Cetanol 2.0
Ipollu extract 0.1
(B) 1,3-butylene glycol 5.0
Diphenhydramine hydrochloride 0.01
Purified water 40.0
(C) Tocopherol nicotinate 0.02
Carrot extract 0.5
Resorcin 0.01
Extract of touki root 0.5
Sesame Flower Extract 1.0
Purple root extract 0.5
Giant root extract 0.5
Purified water 39.56
(D) Fragrance 0.1
(Manufacturing method)
The components (A) and (B) are heated and mixed at 80 ° C. and emulsified. Thereafter, it was cooled to around 40 ° C., component (C) was added, and then (D) was added to prepare a hair rinse.

[Production Example 3] Hair cream compounding ingredients Compounding amount (wt%)
(A) Extract from a magpie 10.0
Liquid paraffin 30.0
Solid paraffin 1.0
Vaseline 15.0
Polyoxyethylene cetyl ether 2.0
Vitamin E acetate 0.2
(B) Diphenhydramine hydrochloride 0.01
Propylene glycol 5.0
Ethyl paraoxybenzoate 0.5
Dipotassium glycyrrhizinate 0.1
Purified water 43.09
(C) Fragrance 0.1
(Manufacturing method)
(A) A component is mixed and dissolved at 80 ° C. Next, the component (B), which was heated and dissolved at 80 ° C. in advance, was added little by little to (A) to form a cream. Thereafter, it was cooled to 40 ° C. and added (C) to prepare a hair cream.

[Production Example 4] Hair essence blending component Blending amount (wt%)
(A) Liquid paraffin 20.0
Solid paraffin 3.0
Polyoxyethylene cetyl ether (B.O 15 mol) 2.0
(B) Oobabenigawa extract 2.0
Glycerin 3.0
Carboxyvinyl polymer 0.1
Ethyl paraoxybenzoate 0.5
Sodium hydroxide 0.1
Dipotassium glycyrrhizinate 0.1
Ethanol 10.0
Purified water 59.20
(Manufacturing method)
The component (A) was heated and dissolved in advance, and the component (B) was sequentially mixed with the component (A) to prepare a hair essence.

As described in detail in the Examples, the composition of the present invention is to provide a novel keratinocyte proliferation promoter having keratinocyte cell proliferation promoting activity that can be used as a hair growth agent or a hair growth agent. Since the keratinocyte growth promoting effect is exhibited, the composition containing the keratinocyte growth promoting agent of the present invention can be used as a hair restorer, a hair growth agent, and the like.

Claims (4)

A keratinocyte growth-promoting agent comprising a 50% by volume ethanol extract of water or water content of Euphorbiaceae alchornea plant . Euphorbiaceae alchornea castaneifolia (Euphorbiaceae alchornea castaneifolia) or (Euphorbiaceae alchornea)
The keratinocyte proliferation promoter according to claim 1, which is floribunnda) or Euphorbiaceae alchornea trewioides. A keratinocyte growth promoting composition comprising the following components (A) and (B):
(A) One or more extracts selected from a water or water content concentration 50% ethanol extract of Euphorbiaceae alchornea plants (B)
One or more selected from whitening agents, antioxidants, anti-inflammatory agents, cell activators, moisturizers, peripheral blood flow promoters   A hair restorer comprising the keratinocyte growth promoter according to any one of claims 1 to 2.