JP5416705B2 - Patch and patch kit - Google Patents

Description

  The present invention relates to a patch containing a transdermal drug having permeability to, for example, skin, nails or stratum corneum, and in particular, a patch having a relatively small size to be applied to a small area such as a nail and The present invention relates to a patch kit.

A conventional patch has a configuration in which an adhesive layer is formed on one side of a film-like support, for example. Such a patch has a release liner for covering the pressure-sensitive adhesive layer. In general patch materials, a single patch material is individually affixed to a release liner of the same shape and size, or a plurality of patch materials are bonded together on a single release liner having a larger area. The pressure-sensitive adhesive layer was covered. The former patch is disclosed in JP-A-62-50623 (Patent Document 1), and the latter patch is disclosed in JP-A-2000-256185 (Patent Document 2). And when using the patch, the user peeled the patch from the release liner and stuck it on the target site.
JP-A-62-50623 JP 2000-256185 A Japanese Utility Model Publication No. 62-42815

However, there is an extremely small size of a few cm ² that is applied to a small area such as a hand or toenail, and the extremely small size adhesive can be handled after peeling from the release liner. There was a problem that it was difficult. That is, even if the user tries to pick a part of the extremely small-sized patch directly with the finger, the entire patch is stuck to the finger. For this reason, it has been difficult to attach the extremely small size patch to the target site accurately. In addition, there is a problem that the position of the pasted adhesive material is shifted or wrinkles occur in the pasted adhesive material. In particular, when applying a patch of extremely small size to the toenail, because the fingers are adjacent to each other, the finger located next to the nail to which the patch is to be applied becomes an obstacle, and the patch is applied to the small nail. It was difficult to apply it accurately. Furthermore, since the user must take an unreasonable posture when applying the patch to the toenail, a patch that can be easily and accurately applied to the toenail is desired.

  In this regard, the patch of Patent Document 2 according to the present applicant is configured such that a part of the patch peeled from the release liner is supported by the knob. With this configuration, the user can easily and accurately attach the patch to the target site by picking the knob. However, the adhesive material of Cited Document 2 has a configuration in which the adhesive layers of a plurality of adhesive materials are collectively covered with a single release liner, and the single adhesive material is individually covered with a single release liner. It wasn't something to do. In addition, since the knob piece is configured to support only one end side of the patch, the other end of the patch is in a free state. Improvements were needed to limit the free state of the side.

  Here, Japanese Utility Model Laid-Open No. 62-42815 (Patent Document 3) discloses a patch in which a mount having a separable central portion is attached to a surface opposite to a surface on which an adhesive layer is formed. Has been. The mount becomes substantially U-shaped after the central portion is divided to support the patch, and prevents wrinkles when the patch is applied. However, in the patch of Patent Document 3, it is necessary to provide a mount separately from the release liner that covers the adhesive layer. Further, depending on the material of the support constituting the patch, it is necessary to add an adhesive layer for attaching the mount to the patch, and there is a problem that the number of layers of the entire patch increases. Furthermore, since the adhesive material and the mount had a shape that coincided with each other, the adhesion area between them was large. For this reason, there also existed a problem that it was difficult to peel a substantially U-shaped mount from the sticking material affixed on the skin.

  The present invention has been made in view of the above problems, and an object of the present invention is to provide a patch and a patch kit that can be easily and accurately applied to a small area such as a nail.

  In order to achieve the above object, a patch according to an embodiment of the present invention is a patch in which an adhesive layer is formed on one side of a support, and the patch is a film that covers the adhesive layer. The release liner can be divided into at least two of a first release liner that covers the central portion of the pressure-sensitive adhesive layer and a second release liner that covers both ends of the pressure-sensitive adhesive layer. And the second release liner includes a grip portion that does not cover the pressure-sensitive adhesive layer, and a pair of support pieces that are coupled to the grip portion at a predetermined interval and cover both end portions of the pressure-sensitive adhesive layer. A portion of the contour of the first release liner matches the contour of the spacing of the second release liner, and another portion of the contour of the first release liner All of the release liner along with contours other than the spacing It is constituted to form a contour.

It is a top view which shows the sticking material which concerns on one Embodiment of this invention. It is the sectional view on the AA line of FIG. It is the schematic which shows the 1st step of the sticking method of the said sticking material. It is the schematic which shows the 2nd step of the sticking method of the said sticking material. It is the schematic which shows the 3rd step of the sticking method of the said sticking material. It is a top view which shows the adhesive material which concerns on other embodiment of this invention. Similarly, it is a top view which shows the adhesive material which concerns on other embodiment of this invention. Similarly, it is a top view which shows the adhesive material which concerns on other embodiment of this invention. Similarly, it is a top view which shows the adhesive material which concerns on other embodiment of this invention. It is a front view which shows the patch as a patch which concerns on one Embodiment of this invention. It is a rear view which shows the patch as said patch. It is a left view which shows the patch as said patch. It is a front view which shows the patch as said patch.

Detailed Description of the Invention

General Description An adhesive material according to an embodiment of the present invention is an adhesive material in which an adhesive layer is formed on one side of a support, and the adhesive material is a film-like release liner that covers the adhesive layer. The release liner can be divided into at least two of a first release liner that covers a central portion of the pressure-sensitive adhesive layer and a second release liner that covers both ends of the pressure-sensitive adhesive layer, 2 release liner has a gripping portion that does not cover the pressure-sensitive adhesive layer, and a pair of support pieces that are coupled to the gripping portion at a predetermined interval and cover both end portions of the pressure-sensitive adhesive layer, A part of the outline of the first release liner matches the outline of the interval of the second release liner, and another part of the outline of the first release liner is an outline other than the interval of the second release liner. Along with the contour of the entire release liner The configuration is as follows.

According to the above configuration, it is possible to easily and accurately affix an extremely small size patch of several cm ² to a small area such as a hand or a toenail. That is, when the user sticks the patch of the present invention on a predetermined site, the user grasps and holds the grip portion of the second release liner with a finger.

  As a first step, the user of the patch material peels the first release liner in a state where the grip part of the second release liner is picked with a finger, and exposes the adhesive layer in the central part of the patch material.

  As a second step, the user temporarily sticks the central portion of the patch to a target site (for example, a toenail) while holding the grip portion of the second release liner with a finger. At this time, since both ends of the patch are supported by the respective support pieces of the second release liner, the patch is maintained without being loosened. Thereby, in the process of moving to the target site, the patch does not become wrinkles or stick to unintended sites, and the patch can be accurately positioned and temporarily applied to the target site. .

  As a third step, the second release liner is peeled from the patch temporarily attached to the target site. That is, each support piece having a small adhesion area to the adhesive material is attached to both ends of the adhesive material by simply pulling the grip part of the second release liner in a predetermined peeling direction with the central part of the temporarily applied adhesive material as a fulcrum. Can be easily peeled off. Thereafter, the application of the patch is completed by pasting both ends of the patch with the adhesive layer exposed to the target site.

  As described above, according to the adhesive material of this embodiment, the grip portion of the second release liner can be gripped to easily handle the extremely small adhesive material, and the central portion of the extremely small adhesive material is temporarily attached. By doing so, it becomes possible to easily and accurately affix to a small area such as a hand or a toenail.

  Here, the “adhesive material” in the present embodiment includes a wide range of adhesive adhesives that have been used in various fields such as the medical industry, industry, and daily life. For example, drugs, adhesive tapes, Articles such as stickers and stickers are applicable. “Release liner” includes a wide range of resin films having good releasability from the pressure-sensitive adhesive layer or thin-film members coated with a resin. The material of the release liner is not particularly limited, but is preferably transparent in order to make it easy to accurately apply the patch to a target site.

  Further, the “first release liner” and the “second release liner” constituting the release liner only have to be separable from each other. For example, when both are completely cut in the thickness direction by a deep cutting line And a case where both are cut to the middle in the thickness direction by a shallow cutting line that is separable.

  Furthermore, in the patch of this embodiment, when the first and second release liners can be divided, “other part of the outline of the first release liner is other than the interval of the second release liner. It is necessary to have a configuration in which the entire contour of the release liner is formed together with the contour. With this configuration, when the first release liner is divided, each support piece of the second release liner is divided into two portions, and only the both ends of the patch are supported by each support piece. At this time, one end side of the interval between the support pieces divided into two is opened. In this state, after temporarily attaching the central portion of the adhesive material to the target site, the grip portion of the second release liner is pulled along the central portion of the adhesive material, that is, along the interval between the support pieces. Then, the second release liner can be smoothly peeled off from both ends of the patch without the support pieces divided into two forks being caught by other parts.

  As described above, the configuration in which “the other part of the outline of the first release liner forms the outline of the entire release liner together with the outline other than the interval of the second release liner” includes the first release liner. After the above is divided, each support piece of the second release liner is divided into two forks, so that one end of each interval is opened widely. For example, the first and second release liners share one side of a generally rectangular release liner, and a cutting line such as a substantially U shape, a substantially semicircular shape, a substantially semielliptical shape, and a substantially trapezoidal shape is formed. And the structure which can divide | segment a 2nd release liner corresponds. Conversely, for example, a configuration in which a circular cutting line is formed at the center of a substantially circular release liner as a whole and can be divided into a substantially circular first release liner and a substantially donut-shaped second release liner. Does not fall under the patch of the present invention.

  Preferably, in the patch of the present embodiment, for example, the release liner is divided from the one film by a substantially U-shaped cutting line, and the first peeling through the cutting line. The first and second release liners include the second release liner that is the remaining part of the film surrounding the liner, and the adhesive layer straddles the two opposing portions of the cutting line. The configuration is affixed to both liners.

  Preferably, in the patch of the present embodiment, with respect to an overlapping portion between one end portion of the pressure-sensitive adhesive layer and one supporting piece, the maximum width of the overlapping portion in a direction intersecting with the supporting piece is set to the supporting piece. And within the range of about 10 to 25% of the maximum width from one end to the other end of the pressure-sensitive adhesive layer in the direction intersecting with, the area of the overlapping portion is about 2 to 30% of the total area of the pressure-sensitive adhesive layer The configuration is within the range.

  More preferably, in the patch of the present embodiment, with respect to the overlapping portion between one end of the pressure-sensitive adhesive layer and one support piece, the maximum width of the overlapping portion is from one end to the other end of the pressure-sensitive adhesive layer. In the range of about 12.5 to 22.0% of the maximum width, the area of the overlapping portion is in the range of about 6 to 20% of the total area of the pressure-sensitive adhesive layer.

  When the maximum width and area of the overlapping part between one end of the pressure-sensitive adhesive layer and one support piece are within the above range, temporary sticking of the patch of this embodiment, and subsequent final sticking It is possible to perform well. That is, the first release liner is peeled off, the adhesive material supported on each support piece of the second release liner is temporarily attached, and the second release liner is peeled off and the adhesive material is finally attached. Both can be performed satisfactorily.

In the patch of the present embodiment, for example, the total area of the support of the patch can be less than 10 cm ² corresponding to a small area such as a hand or a toenail. Preferably, in the adhesive patch of the present invention, the adhesive layer of the adhesive patch is mixed with a drug that is absorbed into the body through the skin, nails or stratum corneum. More preferably, an antifungal agent as the drug is blended in the adhesive layer of the patch.

  According to the above configuration, even if the total area of the patch is extremely small, it can be easily and accurately applied to a predetermined site using the structure of the second release liner. Therefore, the adhesive material of the present invention is suitable for application to a small area such as a toe nail or an intercostal space between toes or a part having a narrow and complicated three-dimensional shape. Therefore, for example, an antifungal agent for treating fungal infections such as ringworm can be blended in the adhesive layer of the patch of the present embodiment. An antimycotic patch that can be easily and accurately applied to the nail or intercostal space is realized.

  The application of the patch of the present embodiment is not limited to pharmaceuticals such as the antifungal patch described above. For example, decoration or marking on a small area or a portion having a narrow and complicated three-dimensional shape. It can be widely applied to a patch to be applied for the purpose.

  A method of applying a patch according to an embodiment of the present invention includes a step of peeling only the first release liner to expose the pressure-sensitive adhesive layer at the center of the patch, A step of temporarily sticking the pressure-sensitive adhesive layer to a predetermined site; and peeling the second release liner from the temporarily stuck patch, and sticking the pressure-sensitive adhesive layers at both ends of the patch to the predetermined site And a step of performing.

  The patch kit according to an embodiment of the present invention is a patch kit including at least the patch of the present invention and an instruction sheet, and the instruction sheet peels only the first release liner. Then, the step of exposing the adhesive layer at the center of the adhesive material, the step of temporarily attaching the adhesive layer at the central portion of the adhesive material to a predetermined site, and the adhesive material temporarily attached A method of applying the adhesive material, including a step of peeling the second release liner and applying the adhesive layers at both ends of the adhesive material to the predetermined site.

Effects of the Invention According to the patch and the patch kit of the present invention, a small area such as a toe nail or an intercostal space between a toe or a finger, or a portion having a narrow and complicated three-dimensional shape is several cm. It is possible to easily and accurately affix an adhesive material of a minimum size of about ² .

DESCRIPTION OF EXEMPLARY EMBODIMENTS Hereinafter, an embodiment of a patch and a method for applying the patch according to the present invention will be described with reference to the drawings. 1 and 2, the patch 1 has a configuration in which an adhesive layer 10 is formed on the back surface of a film-like support, and this adhesive layer 10 is covered with a substantially square release liner 2. The release liner 2 can be divided into two inside and outside by a substantially U-shaped (inverted U-shaped in the figure) cutting line 2a connecting two points on one side thereof, and a small rectangular first release liner 21 and this A large substantially U-shaped second release liner 22 surrounding the first release liner 21 is formed.

[Attachment 1]
Examples of the support constituting the patch 1 include paper such as impregnated paper, coated paper, fine paper, kraft paper, Japanese paper and glassine paper; polyester film, polyethylene film, polypropylene film, polyvinyl chloride film, polycarbonate film, Examples thereof include plastic films such as polyurethane films and cellophane films; foams; non-woven fabrics made of polyester fibers, polyethylene fibers, polypropylene fibers, and the like; fabric base materials such as woven fabrics and knitted fabrics; and laminates thereof. Among these, olefin-based plastic films such as polyethylene are particularly preferable in terms of stretchability and usability. The thickness of the support is preferably 1 μm to 200 μm, more preferably 30 μm to 100 μm, as long as it is a plastic film.

  Examples of the pressure-sensitive adhesive layer 10 formed on the back surface of the support include the following.

<Acrylic adhesive or silicone adhesive>
For example, when the patch 1 according to this embodiment is a nail and / or skin patch, an acrylic pressure-sensitive adhesive or a silicone pressure-sensitive adhesive is blended as the pressure-sensitive adhesive component of the pressure-sensitive adhesive layer 10. In this case, any acrylic pressure-sensitive adhesive or silicone pressure-sensitive adhesive used for general nails and / or skin patches can be used.

  The acrylic pressure-sensitive adhesive is preferably based on a (meth) acrylic acid ester copolymer containing a (meth) acrylic acid alkyl ester having 4 to 12 carbon atoms in the alkyl group as an essential monomer component. Such (meth) acrylic acid alkyl ester monomer components include n-butyl acrylate, n-hexyl acrylate, n-octyl acrylate, 2-ethylhexyl acrylate, isooctyl acrylate, isononyl acrylate, Examples of n-decyl acrylate, isodecyl acrylate, and methacrylic acid ester include methacrylic acid-n-decyl, isodecyl methacrylate, and lauryl methacrylate.

  Among the (meth) acrylic acid alkyl ester monomer components, 2-ethylhexyl acrylate, n-octyl acrylate, isooctyl acrylate, isononyl acrylate, and lauryl methacrylate are particularly preferable.

  In such a (meth) acrylic acid ester copolymer, in addition to the above (meth) acrylic acid alkyl ester as a monomer component, for example, a vinyl monomer having a functional group is preferably blended as another monomer component. Can do. Specific examples include monomers having a hydroxyl group such as 2-hydroxyethyl acrylate, 3-hydroxypropyl acrylate, and 4-hydroxybutyl acrylate; acrylic acid, methacrylic acid, maleic acid, maleic anhydride, itaconic acid And monomers having a carboxyl group such as monobutyl maleate; monomers having an amino group such as acrylamide, dimethylacrylamide, diethylacrylamide, methacrylamide and N-methylolacrylamide; and having an epoxy group such as glycidyl acrylate and glycidyl methacrylate A monomer etc. can be mentioned.

  These vinyl monomers having a functional group can be used alone or in combination of two or more.

  The copolymerization ratio of the above-mentioned other monomer components of the (meth) acrylic acid ester copolymer, for example, a vinyl monomer having a functional group, is preferably 20% by mass or less, more preferably based on the whole copolymer. Is 10% by mass or less.

  In addition to the other monomer components described above, other possible monomer components can be blended in the (meth) acrylic acid ester copolymer. Such components include vinyl esters such as vinyl acetate, unsaturated nitriles such as acrylonitrile and methacrylonitrile, and vinyl aromatic compounds such as styrene. Furthermore, other monomer components that can be contained can be used alone or in combination of two or more. The copolymerization ratio of the monomer component that can be further contained is preferably 30% by mass or less, more preferably 20% by mass or less, based on the entire copolymer.

  The ratio of the (meth) acrylic acid alkyl ester monomer component to the entire (meth) acrylic acid ester copolymer is 60 to 100% by mass, and in particular, the (meth) acrylic acid ester monomer component is co-polymerized. A (meth) acrylic acid ester copolymer containing 70 to 100% by mass with respect to the whole coalescence is preferable.

  Specifically, the (meth) acrylic acid ester copolymer is preferably a copolymer of 2-ethylhexyl acrylate and acrylic acid, and the blending ratio is preferably 85:15 to 99: 1 (mass ratio).

  Such a (meth) acrylic acid ester copolymer can generally be synthesized by radical polymerization. Examples of the polymerization method include a solution polymerization method, an emulsion polymerization method, a bulk polymerization method, and the like, but a solution polymerization method is preferable because good adhesive properties can be obtained.

  In the polymerization reaction, a radical polymerization initiator is added at a ratio of about 0.1 to 1% by mass with respect to the total monomer component mass, and the temperature is about 40 to 90 ° C. under a nitrogen stream for several hours to several times. Stir for 10 hours to polymerize. Examples of the polymerization initiator used here include organic peroxides such as benzoyl peroxide and lauroyl peroxide, and azo initiators such as azobisisobutyronitrile.

On the other hand, as the silicone adhesive, for example, a silicone adhesive described in JP-A-2006-213650 can be used. Examples of the silicone pressure-sensitive adhesive include a mixture or partial condensate of silicone rubber and silicone resin. Examples of the silicone rubber include a high molecular weight linear polydiorganosiloxane having a silicon functional group such as a silanol group at both ends, and the silicone resin includes a monofunctional siloxane unit and a tetrafunctional siloxane unit, Examples thereof include polyorganosiloxanes having a branched or network structure having a silicon functional group such as a silanol group or a methoxy group in the molecule. More specifically, such a silicone rubber is a long-chain copolymer of polydimethylsiloxane, and the silicone resin is an MQ resin (M units ((CH ₃ ) ₃ SiO _1/2 ) and Q units). (Silicone resin having a three-dimensional structure made of (SiO ₂ )).

  The composition ratio of silicone rubber / silicone resin constituting the silicone-based pressure-sensitive adhesive is not particularly limited, but is preferably 30:70 to 60:40, more preferably 35:65 to 45:55 (mass ratio). ). Particularly preferable constituent ratios of silicone rubber / silicone resin in the present invention are 40/60 (w / w) (BIO-PSA4501, Dow Corning), 45/55 (w / w) (BIO-PSA4601, Dow Corning). ) And the like.

  A silicone-based pressure-sensitive adhesive is a pressure-sensitive adhesive having pressure-sensitive adhesive properties due to silicon functional groups present in the molecule. Examples of the organic group bonded to the silicon atom include various monovalent hydrocarbon groups such as methyl, ethyl, vinyl, and phenyl, and the adhesiveness can be adjusted by selecting the type of substituent. The silicone-based pressure-sensitive adhesive is rich in air permeability and moisture permeability because the intermolecular distance of the polyorganosiloxane that is the main component thereof is large.

<Combination of drug in adhesive layer>
When the adhesive layer 10 of the patch 1 according to the present embodiment is mixed with a drug that is absorbed into the body through the skin, nails or stratum corneum, the antifungal agent as a drug is mixed. It is preferable.

  Although the antifungal agent mix | blended with the adhesive layer 10 will not be specifically limited if it is an external medicine, As the specific example, an allylamine antifungal agent (terbinafine, naphthifine, etc.), an imidazole antifungal agent (bihonazole) , Clotrimazole, thioconazole, miconazole, econazole, isoconazole, sulconazole, oxyconazole, croconazole, ketoconazole, neticonazole, ranoconazole, omoconazole, itraconazole, fluconazole, etc.), benzylamine antifungal (butenafine, etc.), morpholine anti Fungal agents (such as amorolfine), thiocarbamine antifungal agents (such as rilanaphthate, naphththiomate N, tolnaphthalate, tolsiclate), fatty acid antifungal agents (undecylenic acid, zinc undecylenate, phenyl) 11-iodo-10-undecinoate, etc.), salicylic acid antifungal agents (salicylic acid, etc.), antifungal antibiotics (siccanin, tricomycin, pyrrolnitrin, nystatin, pimaricin, griseofulvin, variotin, etc.), polyene antifungal agents (Amphotericin B etc.), benzamide antifungal agent (exalamide etc.), pyridone antifungal agent (cyclopirox olamine etc.), iodopropargyl antifungal agent (haloprozine etc.), zinc diethyldithiocarbamate, thianthol, flucytosine, Examples thereof include 2,4,6-tribromophenylcaproic acid ester, trimethylacetylammonium pentachlorophenate, sulfur and bark or their salts.

  The blending ratio of the antifungal agent to the acrylic pressure-sensitive adhesive or silicone pressure-sensitive adhesive can be appropriately determined depending on the type of the antifungal agent, with the upper limit being the amount that can contain the antifungal agent in a dissolved state in the preparation. When the antifungal agent is blended with the acrylic pressure-sensitive adhesive, it is preferably 35% by mass or less, more preferably 5 to 35% by mass, and still more preferably 15 to 15% by mass based on the total mass of the acrylic adhesive. 35 mass%, particularly preferably 20 to 35 mass% is blended.

  When the antifungal agent is blended in the silicone pressure-sensitive adhesive, it is preferably 10% by mass or less, more preferably 0.5 to 10% by mass, and particularly preferably 2 to 10% by mass based on the total mass of the silicone-based adhesive. Mix by mass%.

<Other additives>
The acrylic pressure-sensitive adhesive or silicone pressure-sensitive adhesive that is the pressure-sensitive adhesive component of the pressure-sensitive adhesive layer 10 contains, in addition to the above-mentioned pressure-sensitive adhesive component, fillers, antioxidants, and the like used for general patch materials. Can do. Specifically, calcium carbonate, magnesium carbonate, silicate, zinc oxide, titanium oxide, magnesium sulfate, calcium sulfate can be blended as the filler, and specifically, butylhydroxytoluene can be blended as the antioxidant. .

  Moreover, you may mix | blend the solubilizer for preventing the crystal | crystallization precipitation of the chemical | medical agent in the adhesive layer 10, and the permeation promoter which accelerates | stimulates the chemical | medical agent permeation to a nail | claw and / or skin. Examples of the solubilizer include polyhydric alcohols (glycerin, sorbitol, propylene glycol, 1,3-butylene glycol, 1,3-tetramethylene glycol, polyethylene glycol, etc.), phenols (thymol, safrole, isosafrole, eugenol). , Isoeugenol, etc.), higher alcohols (benzyl alcohol, oleyl alcohol, cetyl alcohol, stearyl alcohol, cetostearyl alcohol, octyldodecanol, etc.), ester surfactants (sorbitan sesquioleate, polyoxyethylene hydrogenated castor oil, Polyoxyl stearate), fatty acid esters (isopropyl myristate, octyldodecyl myristate, oleyl oleate, diethyl phthalate, dibutyl phthalate, etc.) and And organic acids (lactic acid, citric acid, tartaric acid, maleic acid, malic acid, etc.) can be used.

  Examples of such permeation enhancers include fatty acids, fatty acid esters (isopropyl myristate, palmitic isopropyl, diisopropyl sebacate, diethyl sebacate, diisopropyl adipate, diethyl adipate, etc.), fatty acid amides, fatty alcohols, 2- (2 -Ethoxyethoxy) -ethanol, ester of glycerol, glycerol monolaurate, propylene glycol, polyethylene glycol, unsaturated polyglycolized glyceride, saturated polyglyceride, α-hydroxy acid, dimethyl sulfoxide, decylmethyl sulfoxide, pyrrolidones, salicylic acid, Lactic acid, dimethylformamide, dimethylacetamide, sodium dodecyl sulfate, phospholipid, oleic acid, oleic acid / 2- (2-ethoxyethoxy) ethano Le, it is possible to use those selected from proteolytic enzymes.

  Various cross-linking agents can be further added to the pressure-sensitive adhesive component for the purpose of increasing the cohesive strength of the acrylic pressure-sensitive adhesive used for the pressure-sensitive adhesive layer 10. Examples of the crosslinking agent include polyfunctional isocyanate compounds, polyfunctional epoxy compounds, and polyvalent metal salts. Specifically, polyisocyanate (for example, coronate HL (hexamethylene diisocyanate HDI-TMP adduct, Nippon Polyurethane Industry Co., Ltd.)) is preferable.

  On the other hand, various silicone fluids can be added for the purpose of improving the adhesion of the silicone-based pressure-sensitive adhesive used for the pressure-sensitive adhesive layer 10. As such silicone fluid, polydimethylsiloxane fluid, dimethylsiloxane / methylphenylsiloxane copolymer fluid, dimethylsiloxane / methylvinylsiloxane copolymer fluid, dimethylsiloxane Diphenylsiloxane copolymer fluid, dimethylsiloxane / methyl (2-phenylpropyl) siloxane copolymer fluid, dimethylsiloxane / methyl (2-phenylpropyl) siloxane / methyloctylsiloxane copolymer fluid, polyoxyalkylene modified polydimethylsiloxane Fluid can be blended.

In addition, the shape and magnitude | size of the patch 1 mentioned above are not specifically limited. As the shape of the patch 1, various shapes such as a circle, an ellipse, and a nail shape can be adopted in addition to the substantially square shape in FIG. 1. Further, the size of the patch 1 can be appropriately selected according to the area and shape of a predetermined part to which the patch 1 is stuck. Even when the patch 1 has a minimum size of several cm ² , the minimum size patch 1 can be easily and accurately applied to a predetermined site by the release liner 2 described in detail below.

[Release liner 2]
As described above, the release liner 2 can be divided into the first release liner 21 and the second release liner 22 via the cutting line 2a. If the first release liner 21 can be easily divided from the second release liner 22, the cutting line 2 a has a depth that completely cuts the film that forms the entire release liner 2, or the film is halfway Any of the depths to be cut (so-called “half cut”) may be used. In the present embodiment, the release liner 2 is a transparent film, and the state of the predetermined part can be visually recognized through the transparent release liner 2 when the patch 1 is attached to the predetermined part.

  In the present embodiment, the shape of the first release liner 21 is a rectangular shape sharing one side with the release liner 2, but the shape of the first release liner 21 is not particularly limited. The shape of the first release liner 21 covers the central portion 10b of the pressure-sensitive adhesive layer 10 of the patch 1 before being divided from the second release liner 22, and at least externally after being divided from the second release liner 22. Any space 23 (see FIG. 3A) communicating with each other and a pair of support pieces 22 b and 22 c facing each other via the space 23 may be formed on the second release liner 22.

  The second release liner 22 is generally U-shaped as a whole, and includes a gripping portion 22a for a user to grip with a finger, and a pair of support pieces 22b and 22c coupled to the gripping portion 22a with a gap 23 therebetween. Have The support pieces 22b and 22c support the adhesive material 1 without loosening while covering the both end portions 10a and 10c of the adhesive layer 10 of the adhesive material 1 until the final application of the adhesive material 1 is completed. . Thereby, even when only the 1st release liner 21 is peeled and the center part 10b of the adhesive layer 10 of the patch 1 is exposed, the patch 1 becomes a wrinkle or sticks to an unintended part. In this case, the sticking material 1 can be accurately positioned and temporarily attached to the target site. In the present embodiment, the shape of the second release liner 22 is substantially U-shaped. However, as long as it has the gripping portion 22a, the support pieces 22b and 22c, and the interval 23 communicating with the outside, The shape is not particularly limited.

  The release liner 2 described above can be appropriately selected according to the purpose in consideration of the peelability from the pressure-sensitive adhesive layer 10 of the patch 1, air permeability, water permeability, flexibility, and the like. Preferably, a film having a thickness of about 10 to 200 μm made of a polymer material such as polyethylene, polypropylene and polyester is used, and the surface of the film can be treated with silicone or fluorocarbon in order to improve the peelability.

[Positional relationship between patch 1 and release liner 2]
In order to improve the releasability when the first and second release liners 21 and 22 are individually peeled from the adhesive layer 10 of the patch 1, the patch 1 is peeled according to the positional relationship shown in FIGS. Affixed to the liner 2.

  That is, the patch 1 is stuck on both the first and second release liners 21 and 22 so that the pressure-sensitive adhesive layer 10 straddles two opposite sides of the cutting line 2a. Thereby, the center part 10b of the adhesive layer 10 is coat | covered by the 1st peeling liner 21, and the both ends 10a and 10c of the adhesive layer 10 are coat | covered by each support piece 22b and 22c.

  Preferably, as shown in FIG. 1, an excess portion (see a portion surrounded by a chain line of reference numeral 21a) that does not cover the adhesive layer 10 is left on one end side of the first release liner 21, and this excess portion is first peeled off. Let it be a gripping portion 21 a of the liner 21. With such a configuration, the user can easily peel only the first release liner 21 from the central portion 10a of the pressure-sensitive adhesive layer 10 by gripping the grip portion 21a with a finger.

  Further, preferably, as shown in FIG. 1, an excess portion that does not cover the pressure-sensitive adhesive layer 10 is left on the other end side of the first release liner 21, and only both end portions 10 a and 10 c of the pressure-sensitive adhesive layer 10 are the second release liner. 22 to be covered. By setting it as such a structure, the adhesion area of the adhesive layer 10 and the 2nd peeling liner 22 can be made into the minimum required. As a result, the user can easily peel the second release liner 22 from both ends 10a and 10c of the pressure-sensitive adhesive layer 10 after temporarily attaching the central portion 10b of the pressure-sensitive adhesive layer 10 to a predetermined site. It becomes.

[Overlapping part of pressure-sensitive adhesive layer 10 and support pieces 22b and 22c]
As shown in the results of Examples to be described later, an overlapping portion (see reference numeral L1) of one end 10a (or 10c) of the pressure-sensitive adhesive layer 10 shown in FIGS. 1 and 2 and one support piece 22b (or 22c). ) Preferred dimensions. Specifically, the maximum width L1 of the overlapping portion between the one end 10a of the pressure-sensitive adhesive layer 10 and the support piece 22b is the maximum width L2 from one end to the other end of the pressure-sensitive adhesive layer 10 in the direction intersecting the support piece 22b. A range of about 10 to 25% is preferable. Furthermore, the area of the overlapping portion of the one end portion 10a of the pressure-sensitive adhesive layer 10 and the support piece 22b (refer to the reference symbol L1) is within a range of about 2 to 30% of the total area of the pressure-sensitive adhesive layer 10 (refer to the reference symbol L2). It is preferable that

  More preferably, the maximum width L1 of the overlapping portion between the one end portion 10a of the pressure-sensitive adhesive layer 10 and the support piece 22b is about 12.5 to 22.0% of the maximum width L2 from one end of the pressure-sensitive adhesive layer 10 to the other end. Within the range of More preferably, the area of the overlapping portion of the one end portion 10a of the pressure-sensitive adhesive layer 10 and the support piece 22b (see reference L1) is about 6 to 20% of the total area of the pressure-sensitive adhesive layer 10 (see reference L2). It is preferable to be within the range.

  By setting the maximum width and area of the overlapping portion of the pressure-sensitive adhesive layer 10 and the support pieces 22b and 22c within the above range, the pressure-sensitive adhesive force of the pressure-sensitive adhesive layer 10 with respect to each of the first and second release liners 21 and 22 can be increased. It becomes an appropriate size, and all steps of peeling only the first release liner 21, temporarily sticking the patch 1, and peeling the second release liner 22 can be performed satisfactorily.

[Manufacturing method of patch 1]
When manufacturing the patch 1, the method of manufacturing a normal patch can be used as appropriate. Specifically, the manufacturing method described below can be mentioned.

  When using an acrylic pressure-sensitive adhesive based on a (meth) acrylic acid ester copolymer, first, a (meth) acrylic acid ester copolymer was synthesized by, for example, the solution polymerization method described above, and obtained. Using the (meth) acrylic acid ester copolymer solution, a patch is produced by a solution coating method.

  In the solution coating method, firstly, a prepared (meth) acrylic acid ester copolymer (adhesive) solution and an antifungal agent (active ingredient), and a solution to which a crosslinking agent and other additives are added as required are prepared. To this solution, an organic solvent can be added as a diluent to adjust the concentration appropriately.

  Examples of the organic solvent used here include n-hexane, toluene, ethyl acetate, acetone, and methyl ethyl ketone. When these organic solvents are added as a diluent, these organic solvents are used, and the (meth) acrylic acid ester copolymer is preferably 10 to 50% by mass, more preferably based on the total mass of the solution. Prepare a solution containing 20-40% by weight.

  The amount of the antifungal agent to be blended in the solution can be appropriately determined according to the type of the antifungal agent and the amount of the (meth) acrylic acid ester copolymer. The amount of the crosslinking agent and other additives can be appropriately determined according to the amount of each component.

  Next, the solution (diluent) containing each component is stirred to uniformly dissolve and disperse each component. The solution thus obtained is uniformly applied to, for example, the back surface of the support of the patch 1 or the surface of the release liner 2 using a coating machine such as a knife coater, comma coater or reverse coater. The coating amount of the solution can be appropriately determined according to the thickness of the target acrylic or silicone pressure-sensitive adhesive layer 10, the type of pressure-sensitive adhesive used, the type of antifungal agent, and the amount thereof. Preferably, the solution is applied so as to have a thickness of 10 to 400 μm, more preferably 20 to 300 μm after drying.

  After coating, the organic solvent is volatilized by holding for about 30 seconds to 10 minutes in a dry heat atmosphere maintained at a temperature of about 40 ° C to 130 ° C. The drying conditions are appropriately selected depending on the type of the organic solvent to be used and the thickness of the pressure-sensitive adhesive layer 10 to be applied.

  By laminating the release liner 2 or the support on the pressure-sensitive adhesive layer 10 obtained by the above method, the patch 1 with the release liner 2 according to this embodiment can be obtained.

[Preferred specifications of patch 1]
The release liner 2 has a bending resistance measured according to JIS (Japanese Industrial Standard (s)) L1096 (Method A: 45 ° cantilever method) of about 35 mm, or bending resistance (Method D: Heart Loop). Method) is about 100 mm.

  The adhesive strength of the pressure-sensitive adhesive layer 10 is preferably about 1.5 to 2.0 N / 10 mm, more preferably 1.65 to 1.85 N / 10 mm, with respect to the stainless steel plate measured according to JIS Z0237. . However, the stainless steel plate used for measuring the adhesive strength is SUS304BA defined in JIS.

  The adhesive force (peeling force) of the pressure-sensitive adhesive layer 10 to the release liner 2 is preferably 10 to 20 mN / 10 mm with respect to the release liner adhesive force measured according to JIS Z0237. However, the release liner 2 used for measuring the adhesive force is a silicone-treated PET film.

[Attaching method of patch 1]
Next, the usage method of the patch 1 which concerns on this embodiment is demonstrated, referring FIG. As shown in FIG. 3A, when the user sticks the patch 1 to a predetermined site, for example, a toenail, the user grasps and holds the grip 22a of the second release liner 2 with a finger.

  As a first step, as shown in FIG. 3A, the user of the patch 1 peels only the first release liner 21 in a state where the grip 22a of the second release liner 2 is picked with a finger. The first release liner 21 is peeled off by grasping the grip portion 21a not covering the pressure-sensitive adhesive layer 10 with a finger. By peeling the first release liner 21, the adhesive layer 10 b at the center of the patch 1 is exposed, and a gap 23 is formed in the second release liner 22. As a result, only the both end portions (see reference numerals 10 a and 10 c) of the patch 1 are supported by the pair of support pieces 22 b and 22 c of the second release liner 2.

  As a second step, as shown in FIG. 3B, the user temporarily sticks the central portion (see reference numeral 10b) of the patch 1 to the toenail while holding the grip portion 22a of the second release liner 2 with a finger. To do. At this time, since both ends (refer to reference numerals 10a and 10c) of the patch 1 are respectively supported by the support pieces 22b and 22c of the second release liner 22, the patch 1 does not loosen. Thereby, in the process of moving the patch 1 to the toenail, the patch 1 does not become a wrinkle or stick to an unintended part, and the patch 1 is accurately positioned on the toenail. Can be temporarily attached.

  As a 3rd step, as shown in Drawing 3C, the 2nd exfoliation liner 22 is exfoliated from patch 1 temporarily stuck on a toenail. That is, by simply pulling the gripping portion 22a of the second release liner 22 in the longitudinal direction of the interval 23 (see the white arrow in the figure) using the central portion (see reference numeral 10b) of the temporarily stuck patch 1 as a fulcrum. Each support piece 22b, 22c having a small adhesion area to the patch 1 can be easily peeled from both ends (see reference numerals 10a, 10c) of the patch 1. Then, sticking of the patch 1 is completed by sticking the both ends of the patch 1 where the adhesive layers 10a and 10c are exposed to the toenails.

  As described above, according to the patch 1 of the present embodiment, the minimal size patch 1 can be easily handled by grasping the grip portion 22a of the second release liner 22 with a finger, and the minimal size patch. By temporarily sticking the central portion of 1, it becomes possible to stick it easily and accurately to a small area such as a hand or a toenail.

[Example]
Using the patch materials (Examples 1 to 14) having the specifications shown in Table 1 below, performance evaluation of the patch materials was performed by five adult male and female subjects. The application site of the patch in this example was a toenail. Further, the performance to be evaluated for the patch was set to two items of “ease of temporary sticking” and “ease of sticking”.

The patch materials of Examples 1 to 14 were obtained by the following composition and manufacturing method.
1. Terbinafine ^{* 1} 30.0%
2. Acrylic adhesive ^{* 2} 69.84% (solid content)
3. Polyisocyanate ^{* 3} 0.16%
^{* 1} : Purchased from Kaneda Corporation
^{* 2} : 96% acrylic acid-2-ethylhexyl and 4% acrylic acid could be polymerized by a conventional solution polymerization method using 1.0 part of a polymerization initiator lauroyl peroxide.
^{* 3} : Coronate HL (Nippon Polyurethane Industry Co., Ltd.)
(Production method) After weighing the above components, the total solid content was adjusted to 25% in ethyl acetate and stirred until uniform. It is coated on a 75 μm single-sided silicone-treated PET (polyethylene terephthalate) film (Film Binner 75E-0010 BD, Fujimori Kogyo Co., Ltd.) so that the thickness of the pressure-sensitive adhesive layer after drying is 60 μm. Dried. Subsequently, a 60 μm polyethylene film (Toray Industries, Inc.) was bonded to one side of the pressure-sensitive adhesive layer to obtain a patch.

  In the evaluation item “ease of temporary sticking”, in the process of temporarily sticking the patch, only the first release liner can be easily peeled off, and each support piece of the second release liner has both ends. It is possible to easily and accurately temporarily apply the adhesive material supported on the toenails. On the other hand, “ease of sticking”, which is an evaluation item, indicates that the second release liner can be easily peeled off from the temporarily stuck patch, and that the patch that has been finally pasted is wrinkled or drowned. Is included.

The evaluation criteria for “ease of temporary sticking” and “ease of sticking” are as follows.
Evaluation A: It was judged that 4 to 5 subjects were good.
Evaluation B: It was judged that 2 to 3 subjects were good.
Evaluation C: One subject was judged to be good. Or there is no subject judged to be good.

  Among Examples 1 to 14, Examples 1 to 9 had an evaluation A for both “temporary sticking ease” and “easy sticking”. In Examples 10 to 14, both or one of “ease of temporary attachment” and “ease of application” was evaluated B. The reason why Examples 10 to 14 were evaluated as B was that “L1 / L2 (%)” was outside the range of about 10 to 25%, and “right area / total area (%) ) ”Or“ left area / total area (%) ”is considered to be out of the range of about 6 to 20%. However, if it has the performance of evaluation B, it is worth actually implementing the patch of Examples 10-14.

[Comparative example]
Based on the configuration shown in FIG. 3 of the above-mentioned Japanese Utility Model Publication No. 62-42815 (Patent Document 3), the entire pressure-sensitive adhesive layer of the patch has the same shape as the patch and is substantially U-shaped. The comparative example of the structure coat | covered with the release liner which has the following cutting line was created. Using this comparative example, “ease of temporary sticking” and “ease of sticking” were evaluated under the same conditions as described above. As a result, the “easiness of temporary sticking” was an evaluation A, and the “ease of sticking” was an evaluation C.

  In the comparative example, since the entire pressure-sensitive adhesive layer of the patch was covered with the release liner, it was difficult to peel the second release liner from the temporarily stuck patch. In particular, it takes a lot of work to pull and peel the second release liner. However, if the second release liner is pulled and peeled with excessive force, the temporarily stuck patch will cause significant wrinkles and wrinkles. Did not become a normal use state.

  Here, the configuration shown in FIG. 3 of Patent Document 3 is obtained by forming a substantially U-shaped “cut line 40” on a “mount 40” provided separately from the “release liner 30”. Thus, it is not a configuration in which the release liner can be divided into two by a substantially U-shaped cutting line.

  In addition, the adhesive material of this invention is not limited to embodiment mentioned above. For example, the overall shape of the release liner 2 and the shape of the cutting line 2a are not limited to the shapes shown in FIGS. For example, the shape of the cutting line 2a may be semi-elliptical (see FIG. 4A), trapezoid (see FIG. 4B), inverted trapezoid (see FIG. 4C), or the like. Further, as shown in FIG. 4C, when the grip portion 21 of the first release liner 21 protrudes from one side of the second release liner 22, only the first release liner 20 is more easily peeled off.

  Further, the shape of the patch 1 is not limited to the shape shown in FIGS. 1 and 2. For example, the shape of the patch 1 may be circular (not shown), oval (see FIG. 4B), nail shape (see FIGS. 5A and 5B), or the like.

  Furthermore, the use of the patch of the present invention is not limited to pharmaceutical products such as the patch for antimycosis as in the above embodiment. For example, the present invention can be widely applied to an extremely small-sized adhesive material to be applied to a small area, such as a decorative seal such as a nail seal, a pierce seal, and a tattoo seal, and a dry decal for decorating a plastic model. Even when applied to such applications, as in the above-described embodiment, an extremely small-sized patch can be easily and accurately applied to a small-area site.

[Others]
Finally, the external structure of the patch as a patch according to an embodiment of the present invention is shown in FIGS. Since the right side view appears symmetrically with the left side view, it is omitted. Similarly, the bottom view will be omitted because it appears symmetrically with the plan view.

  The patch 1 is a support made of a film having a shape corresponding to a human nail, an adhesive layer 10 containing a drug formed on the back surface of the support, and the adhesive layer 10 is covered from the back side. A film-like release liner 2 is provided. The release liner 2 is provided with an inverted U-shaped cutting line 2a as shown in the front view or the rear view. The release liner 2 can be divided into the first and second release liners 21 and 22 through the cutting line 2a.

  The patch 1 is handled by gripping the grip 22a of the second release liner 22 with a finger. When affixing the patch 1, first, only the first release liner 21 is peeled off, and the adhesive layer 10 at the center of the patch 1 is temporarily affixed to the affected part (for example, toenails). Then, the 2nd peeling liner 22 is peeled and the adhesive layer 10 of the both ends of the patch 1 is affixed on an affected part.

DESCRIPTION OF SYMBOLS 1 Adhesive material 10 Adhesive layer 10a, 10c End part 10b Center part 2 Release liner 2a Cutting line 21 1st release liner 21a Gripping part 22 2nd peeling liner 22a Gripping part 22b, 22c Supporting piece 23 space | interval

Claims (8)

A patch having an adhesive layer formed on one side of a support,
The patch has a film-like release liner that covers the pressure-sensitive adhesive layer,
The release liner can be divided into at least two of a first release liner that covers the central portion of the pressure-sensitive adhesive layer and a second release liner that covers both ends of the pressure-sensitive adhesive layer,
The second release liner includes a grip portion that does not cover the pressure-sensitive adhesive layer, and a pair of support pieces that are coupled to the grip portion at a predetermined interval and cover both end portions of the pressure-sensitive adhesive layer. ,
A part of the outline of the first release liner matches the outline of the interval of the second release liner, and another part of the outline of the first release liner is other than the interval of the second release liner. A patch for forming the outline of the entire release liner together with the outline. The release liner is the first release liner divided from one film by a substantially U-shaped cutting line, and the remaining part of the film surrounding the first release liner through the cutting line. Consisting of two release liners,
The patch according to claim 1, wherein the patch is stuck to both the first and second release liners so that the pressure-sensitive adhesive layer straddles two portions of the cutting line facing each other. About the overlapping part between one end of the pressure-sensitive adhesive layer and one of the support pieces,
The maximum width of the overlapping portion in the direction intersecting the support piece is within a range of about 10 to 25% of the maximum width from one end to the other end of the pressure-sensitive adhesive layer in the direction intersecting the support piece,
The patch according to claim 1 or 2, wherein an area of the overlapping portion is within a range of about 2 to 30% of a total area of the pressure-sensitive adhesive layer. About the overlapping part between one end of the pressure-sensitive adhesive layer and one of the support pieces,
The maximum width of the overlapping portion is within a range of about 12.5 to 22.0% of the maximum width from one end to the other end of the pressure-sensitive adhesive layer,
The patch according to claim 3, wherein an area of the overlapping portion is within a range of about 6 to 20% of a total area of the pressure-sensitive adhesive layer. Patch as claimed in any one of claims 1 to 4, the total area of the support of the patch was less than 10 cm ^2.   The patch according to any one of claims 1 to 5, wherein a drug that is absorbed into the body through the skin, nails, or stratum corneum is blended in the adhesive layer of the patch.   The patch according to claim 6, wherein an antifungal agent as the drug is blended in the adhesive layer of the patch. At least a patch kit comprising a set of the patch according to any one of claims 1 to 7 and instructions,
The instructions include
Peeling only the first release liner to expose the adhesive layer at the center of the patch; and
Temporarily sticking the adhesive layer at the center of the patch to a predetermined site;
Peeling the second release liner from the temporarily stuck patch, and pasting the adhesive layers at both ends of the patch to the predetermined site;
A patch kit that describes a method of sticking the patch, comprising:

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