JP5453715B2 - Hair nurturing agent and transdermal absorption enhancer - Google Patents

Description

  The present invention relates to a skin external preparation composition that promotes the percutaneous absorption of an active ingredient for nourishing hair by applying it externally to the scalp hair, and more specifically, by improving the percutaneous absorption of the active ingredient for nourishing hair, the nourishing hair The present invention relates to a scalp hair cosmetic that exhibits its effect more effectively and has an excellent feeling during use.

  In general, in a hair restorer containing a hair-growth active ingredient, the hair-growth active ingredient penetrates into the skin and expresses its effect. Therefore, in order to enhance the effect of the active nourishing hair ingredient, it is important to improve the skin permeability of the active nourishing hair ingredient. In skin external preparations such as cosmetics, ingredients that exhibit moisturizing action, whitening action, anti-inflammatory action, etc. by percutaneous absorption are used, but the stratum corneum, which is the outermost layer of the skin, is essentially a foreign substance. Since it has a physiological function as a barrier to prevent invasion, it is not possible to obtain sufficient transdermal absorbability simply by adding such a substance to an external preparation, and it fully exhibits the original action of the active ingredient. I couldn't. Moreover, even if the substance shows an excellent effect by being absorbed by the skin, there are many substances that cannot exhibit the original effect because of the low transdermal absorbability in the stratum corneum.

  For this reason, in recent years, for the purpose of improving the transdermal absorbability of various active ingredients, for example, surfactants, various oils, terpenes and the like have been proposed. Specifically, a percutaneous absorption enhancer containing a narcotic analgesic (Patent Document 1: JP-A-4-217926), a nicergoline as an active ingredient in the base of a transdermal absorption preparation, A transdermal preparation containing an absorption accelerator (Patent Document 2: see JP-A-5-25046), an absorption accelerator consisting of hexylene glycol and l-menthol (Patent Document 3: JP 2000-119195A) Etc.) have been proposed. However, these methods for improving transdermal absorbability do not provide sufficient transdermal absorbability, and when used in a large amount to improve transdermal absorbability, the feeling of use such as stickiness is deteriorated. There was a thing. For this reason, there has been a demand for a scalp hair cosmetic that further improves transdermal absorbability and has a good feeling when used. In addition, the following is mentioned as a prior art document relevant to this invention.

JP-A-4-217926 JP-A-5-25046 JP 2000-119195 A JP-A-4-145015 JP 2001-302462 A JP 58-180407 A

  The present invention improves the percutaneous absorption of active ingredients for nourishing hair by applying it externally to the scalp hair, and particularly has an effect of promoting hair growth and preventing hair loss by applying it externally to the scalp. An object of the present invention is to provide a scalp hair cosmetic with excellent feeling.

  The present inventor uses menthol and an amino acid-based nonionic surfactant to promote percutaneous absorption of a nourishing hair active ingredient, and when using a scalp hair cosmetic comprising these ingredients and a nourishing hair active ingredient, It has been found that there is no stickiness and excellent usability, and the present invention has been made.

Accordingly, the present invention provides the following hair nurturing agent and transdermal absorption enhancer.
[1]. One or more kinds of hair-growth active ingredients selected from the following (A) cell activator, (B) blood flow improving agent, (C) anti-inflammatory agent, (D) bactericidal agent and (E) local stimulant Menthol, 0.1 to 2.5 % by weight of the following amino acid-based nonionic surfactant, and 0.1 to 10% by weight of ester oil which is liquid at 25 ° C., selected from essence, tonic and hair cream Nourishing hair .
Nourishing hair active ingredients:
(A) Cell activator: pentadecanoic acid glyceride, pantothenyl alcohol, pantothenyl ethyl ether, adenosine (B) blood flow improving agent: carpronium chloride, tocopherol acetate, assembly extract, nicotinamide (C) anti-inflammatory agent: β- Glycyrrhetinic acid, glycyrrhetinic acid stearyl, glycyrrhizic acid, ammonium glycyrrhizinate, trisodium glycyrrhizinate, dipotassium glycyrrhizinate, methyl glycyrrhizinate (D) fungicide: isopropylmethylphenol, salicylic acid, hinokitiol, zinc pyrithione, piroctone olamine (E) topical Stimulants: benzyl nicotinate and nonyl acid vanillylamide amino acid nonionic surfactant:
Lauroylglutamate dihexyldecyl, stearoylglutamate dioctyldodecyl, lauroylglutamate dioctyldecyldecyl, lauroylglutamate polyoxyethyleneoctyldodecylether diester, lauroylglutamate polyoxyethylenestearyletherdiester, myristoylmethylaminohexyloxydecylate pyrostearate one or more members selected from castor Abura及 beauty pyroglutamic acid glyceryl oleate
Ester oil in liquid form at 25 ° C:
Propylene glycol dicaprate, neopentyl glycol dicaprate, pentaerythritol tetra2-ethylhexanoate, propylene glycol monocaprylate, propylene glycol dicaprylate, trimethylolpropane tri-2-ethylhexanoate, glyceryl tri-2-ethylhexanoate, 2 -2-butyl-2-ethyl-1,3-propanediol ethylhexanoate, 2-ethylhexyl hydroxystearate, cholesteryl hydroxystearate, isostearyl lactate, octyldodecyl lactate, triethylhexyl citrate, acetyltriethyl citrate, citrate Acetyl tributyl, diisostearyl malate, diethylhexyl succinate, diisopropyl adipate, diisobutyl adipate, diocty adipate , Hexyl adipate tri-2-ethyl, one or more compounds selected from diethyl sebacate and diisopropyl sebacate [2]. Nourishing hair active ingredients
(A) Cell activating agent: pantothenyl alcohol, pantothenyl ethyl ether, adenosine (B) blood flow improving agent: carpronium chloride, nicotinamide (C) anti-inflammatory agent: β-glycyrrhetinic acid, stearyl glycyrrhetinate, glycyrrhizic acid, Ammonium glycyrrhizinate, trisodium glycyrrhizinate, dipotassium glycyrrhizinate, methyl glycyrrhizinate (D) fungicide: isopropylmethylphenol, salicylic acid, hinokitiol, zinc pyrithione, piroctone olamine (E) local stimulant: selected from nonylic acid vanillylamide The hair nurturing agent according to [1].
[3]. The hair nurturing agent according to [1] or [2], wherein the amount of menthol is 0.01 to 2.0 mass%.
[4]. Furthermore, the hair restoring agent in any one of [1]-[3] containing 0.1-3 mass% of polyhydric alcohols.
[5]. The polyhydric alcohol is one or more selected from polyethylene glycol, propylene glycol, dipropylene glycol, glycerin, ethylene glycol, diethylene glycol, triethylene glycol, pentanediol, isoprene glycol, hexanediol and 1,3-butylene glycol. [4] The hair nurturing agent according to [4].
[ 6 ]. (A) Pentadecanoic acid glyceride, pantothenyl alcohol, pantothenyl ethyl ether, adenosine, biotin, placenta extract, mononitroguaiacol, (B) nicotinamide, tocopherol acetate, carpronium chloride, assembly extract, nicotinamide, minoxidil, cephalanthin , Carrot extract, (C) β-glycyrrhetinic acid, dipotassium glycyrrhizinate, ammonium glycyrrhizinate, (D) isopropylmethylphenol, hinokitiol, piroctone olamine, zinc pyrithione, salicylic acid, benzalkonium chloride, propolis and (E) nicotinic acid One or more active hair-growth ingredients selected from benzyl,
With menthol,
Lauroylglutamate dihexyldecyl, lauroylglutamate dioctyldodecyl, stearoylglutamate dioctyldodecyl, pyroglutamate oleic acid glyceryl, lauroylglutamate POE (2) octyldodecyl ether diester, pyroglutamate isostearic acid POE (30) hydrogenated castoramic acid POE (30) 40) hardened castor oil, peak b glutamic acid isostearate POE (50) hardened castor oil, lauroyl glutamic acid POE (5) octyl dodecyl ether diester, lauroylglutamic acid POE (2) stearyl ether diester, lauroylglutamic acid POE (5) stearyl ether diester, And hexyldecyl myristoylmethylaminopropionate Amino acid-based nonionic surfactant one selected et or more and 0.1 to 2.5 wt%,
One or more polyhydric alcohols selected from polyethylene glycol, propylene glycol, glycerin, 1,3-butylene glycol, isoprene glycol and pentanediol;
Propylene glycol monocaprylate, 2-ethylhexyl hydroxystearate, octyldodecyl lactate, triethylhexyl citrate, acetyltriethyl citrate, pentaerythritol tetra-2-ethylhexanoate, diisopropyl adipate, diethyl sebacate, diisostearyl malate, hydroxystearic acid 2-ethylhexyl, containing the neopentyl glycol dicaprate, liquid ester oil one at 25 ° C. selected from propylene glycol dicaprate and glyceryl tri-2-ethylhexanoate or 2 or more, essences, tonics and Hair nourishing agent selected from hair creams .
[ 7 ]. (A) pantothenyl alcohol, adenosine, (B) nicotinic acid amide, (C) β-glycyrrhetinic acid and (D) one or more kinds of nourishing hair active ingredients selected from isopropylmethylphenol,
With menthol,
Amino acid nonionic surfactant 1 selected from lauroyl glutamic acid POE (2) stearyl ether diester, lauroyl glutamic acid POE (5) stearyl ether diester, hexyldecyl myristoylmethylaminopropionate and isostearic acid pyrostearate POE (30) hydrogenated castor oil 0.1 to 2.5 mass% of seeds or two or more kinds,
One or more polyhydric alcohols selected from polyethylene glycol, propylene glycol, glycerin and 1,3-butylene glycol;
A hair nurturing agent selected from essence, tonic and hair cream, containing at least one ester oil that is liquid at 25 ° C selected from propylene glycol monocaprylate, 2-ethylhexyl hydroxystearate, and octyldodecyl lactate .
[ 8 ]. One or more kinds of hair-growth active ingredients selected from the following (A) cell activator, (B) blood flow improving agent, (C) anti-inflammatory agent, (D) bactericidal agent and (E) local stimulant Menthol, 0.1 to 2.5% by mass of the following amino acid nonionic surfactant , and a polyhydric alcohol selected from polyethylene glycol, propylene glycol, glycerin, 1,3-butylene glycol, isoprene glycol and pentanediol Or the above-mentioned nurturing containing 2 or more types and one or more ester oils liquid at 25 ° C. selected from propylene glycol monocaprylate, 2-ethylhexyl hydroxystearate, octyldodecyl lactate and triethylhexyl citrate Transdermal absorption enhancer of hair active ingredients.
(A) Cell activator: pentadecanoic acid glyceride, pantothenyl alcohol, pantothenyl ethyl ether, adenosine (B) blood flow improving agent: carpronium chloride, tocopherol acetate, assembly extract, nicotinamide (C) anti-inflammatory agent: β- Glycyrrhetinic acid, stearyl glycyrrhetinate, glycyrrhizic acid, ammonium glycyrrhizinate, trisodium glycyrrhizinate, dipotassium glycyrrhizinate, methyl glycyrrhizinate (D) fungicide: isopropylmethylphenol, salicylic acid, hinokitiol, zinc pyrithione, piroctone olamine (E) topical Stimulants: benzyl nicotinate and nonyl acid vanillylamide amino acid nonionic surfactant:
Lauroylglutamate dihexyldecyl, stearoylglutamate dioctyldodecyl, lauroylglutamate dioctyldecyldecyl, lauroylglutamate polyoxyethyleneoctyldodecylether diester, lauroylglutamate polyoxyethylenestearyletherdiester, myristoylmethylaminohexyloxydecylate pyrostearate one or more members selected from castor Abura及 beauty pyroglutamic acid glyceryl oleate

  By incorporating menthol and an amino acid-based nonionic surfactant as a transdermal absorption enhancer of the active hair-restoring ingredient into the scalp hair cosmetic containing the active hair-restoring ingredient of the present invention, transdermal absorption of the active hair-restoring ingredient is carried out. Can be promoted, excellent hair growth can be demonstrated, and the usability of scalp hair cosmetics can be improved.

It is a perspective view of the Franz diffusion cell used for the test of the present invention. It is explanatory drawing explaining the test method using a Franz-type diffusion cell.

Explanation of symbols

1 Franz diffusion cell 2 Donor 3 Receptor 4 Stirrer 5 Back peeling skin

The hair-growth active ingredient of the present invention is one or more selected from the following (A) cell activator, (B) blood flow improving agent, (C) anti-inflammatory agent, (D) bactericidal agent and (E) local stimulant. 2 or more types.
(A) Cell activating agent: pantothenic acid and derivatives thereof, adenosine, placenta extract, photosensitizer, biotin, pentadecanoic acid glyceride, adenine and derivatives thereof, thymine and derivatives thereof, cytosine and derivatives thereof, uracil and derivatives thereof Derivatives, astilbine and derivatives thereof, and mononitroguaiacol (B) blood flow improving agent: carpronium chloride, vitamin E derivatives, assembly extract, cephalanthin, nicotinamide, carrot extract and minoxidil (C) anti-inflammatory agent: glycyrrhetinic acid and its Derivatives and glycyrrhizic acid and its derivatives (D) fungicides: isopropylmethylphenol, salicylic acid, hinokitiol, benzalkonium chloride, benzethonium chloride, trichlorocarbanilide, zinc pyrithi Down, 1-hydroxy-2-pyridone compounds and their salts, and propolis (E) topical stimulants: Waniriruamido benzyl nicotinate and nonyl acid

  (A) Among cell activators, pantothenic acid such as pentadecanoic acid glyceride, pantothenyl alcohol, pantothenyl ethyl ether and derivatives thereof, and adenosine are preferable.

  (B) As a blood flow improving agent, vitamin E derivatives such as carpronium chloride and tocopherol acetate, assembly extract, and nicotinamide are preferable.

  (C) Specific examples of the anti-inflammatory agent include glycyrrhetinic acid such as β-glycyrrhetinic acid and stearyl glycyrrhetic acid and derivatives thereof, glycyrrhizic acid, ammonium glycyrrhizinate, trisodium glycyrrhizinate, dipotassium glycyrrhizinate, methyl glycyrrhizinate, and the like. Glycyrrhizic acid and its derivatives are preferred, and among them, β-glycyrrhetinic acid and dipotassium glycyrrhizinate are preferred.

  (D) As the disinfectant, 1-hydroxy-2-pyridone compounds such as isopropylmethylphenol, salicylic acid, hinokitiol, zinc pyrithione, piroctone olamine, and salts thereof are preferable.

  (E) Among local stimulants, benzyl nicotinate is preferred.

  (A) When mix | blending a cell activator, the compounding quantity in the scalp hair cosmetics of a cell activator is 0.001-5.0 mass% normally, 0.01-4.0 mass% is preferable, More preferably, it is 0.05-3.0 mass%. The upper limit of the amount is further preferably 2.0% by mass or less, and particularly preferably 1.0% by mass or less. If the amount is too small, a sufficient effect may not be obtained, and if it is too much, it may be uneconomical.

  (B) When mix | blending a blood flow improving agent, the compounding quantity in the scalp hair cosmetics of a blood flow improving agent is 0.001-5.0 mass% normally, and 0.01-2.0 mass% is Preferably, it is 0.05 to 1.0% by mass. If the amount is too small, a sufficient effect may not be obtained.

  (C) When mix | blending an anti-inflammatory agent, the compounding quantity in the scalp hair cosmetics of an anti-inflammatory agent is 0.001-2.0 mass% normally, 0.01-1.0 mass% is preferable, More preferably, it is 0.05-0.5 mass%. If the amount is too small, a sufficient effect may not be obtained, and if it is too much, it may be uneconomical.

  (D) When mix | blending a disinfectant, the compounding quantity in scalp hair cosmetics of a disinfectant is 0.001-2.0 mass% normally, 0.005-1.0 mass% is preferable, More preferably Is 0.01-0.5 mass%. If the amount is too small, a sufficient effect may not be obtained.

  (E) When a local stimulant is blended, the blended amount of the local stimulant in the scalp hair cosmetic is usually 0.00001 to 2% by mass, preferably 0.00005 to 0.5% by mass, more preferably. Is 0.0001-0.1 mass%. If the amount is too small, a sufficient effect may not be obtained.

  The menthol (1-menthol) of the present invention is used as a percutaneous absorption enhancer of a nourishing hair active ingredient. The blending amount of menthol in the scalp hair cosmetic is usually 0.001 to 5% by mass, preferably 0.01 to 2.0% by mass, more preferably 0.05 to 1.0% by mass, More preferably, it is 0.25-1.0 mass%. Within this range, the effect of improving the percutaneous absorption and usability of the active hair-restoring ingredient can be obtained.

  The amino acid-based nonionic surfactant of the present invention is used as a percutaneous absorption enhancer of a nourishing hair active ingredient. Examples of the amino acid-based nonionic surfactant include amino acid-based nonionic surfactants represented by the following general formulas (1) to (4), which can be used singly or in appropriate combination of two or more.

（式中、Ｒ¹ＣＯは独立に炭素数８〜２２の直鎖又は分岐鎖の長鎖アシル基であり、Ｒ¹は飽和又は不飽和の一価炭化水素基である。Ｒ²はコレステロールのエステル生成残基、炭素数８〜３３の直鎖又は分岐鎖の高級アルコールのエステル生成残基であり、ａ、ｂ及びｃは全て０又は独立に１〜３０の数である。）

(In the formula, R ¹ CO is independently a linear or branched long-chain acyl group having 8 to 22 carbon atoms, R ¹ is a saturated or unsaturated monovalent hydrocarbon group, and R ² is cholesterol. An ester-forming residue, an ester-forming residue of a linear or branched higher alcohol having 8 to 33 carbon atoms, and a, b and c are all 0 or independently a number of 1 to 30.)

  Specific examples of the compound represented by the general formula (1) include dihexyl decyl lauroyl glutamate, dioctyl dodecyl stearoyl glutamate, dioctyl dodecyl lauroyl glutamate, and the like. Examples of the compound represented by the general formula (2) include lauroyl glutamic acid polyoxyethylene octyldodecyl ether diester, lauroyl glutamic acid polyoxyethylene stearyl ether diester, and the like. Examples of the compound represented by the general formula (3) include pyroglutamic acid isostearate polyoxyethylene hydrogenated castor oil. Examples of the compound represented by the general formula (4) include glyceryl pyroglutamate oleate, and examples of the other amino acid-based nonionic surfactant include polyoxyethylene glyceryl pyrostearate. Among them, lauroylglutamate dihexyldecyl, stearoylglutamate dioctyldodecyl, lauroylglutamate dioctyldodecyl, lauroylglutamate POE (2) octyldodecyl ether diester, lauroylglutamate POE (2) stearyl ether diester, myristoylmethylaminopropyrate hexyldestearate Acid POE (30) hydrogenated castor oil, pyroglutamate isostearate POE (25) glyceryl, pyroglutamate oleate glyceryl are preferred.

  The compounding amount of the amino acid-based nonionic surfactant in the scalp hair cosmetic is 0.01 to 3% by mass, preferably 0.1 to 3% by mass. If the blending amount is too small, the effect of promoting percutaneous absorption of the active hair-restoring ingredient cannot be sufficiently exerted, and if it is too much, stickiness is produced during use.

  In the scalp hair cosmetic of the present invention, the effect of promoting percutaneous absorption of a nourishing hair active ingredient is further improved by blending polyhydric alcohol and liquid ester oil at 25 ° C. Examples of the polyhydric alcohol include polyethylene glycol, propylene glycol, dipropylene glycol, glycerin, ethylene glycol, diethylene glycol, triethylene glycol, pentanediol, isoprene glycol, and hexanediol. These can be used individually by 1 type or in combination of 2 or more types.

  When mix | blending a polyhydric alcohol, 0.05-5 mass% is preferable, and, as for the compounding quantity in scalp hair cosmetics, More preferably, it is 0.1-3 mass%.

  Examples of liquid ester oils at 25 ° C. include propylene glycol dicaprate, neopentyl glycol dicaprate, pentaerythritol tetra-2-ethylhexanoate, propylene glycol monocaprylate, propylene glycol dicaprylate, trimethylolpropane tri-2-ethylhexanoate. Glyceryl tri-2-ethylhexanoate, 2-butyl-2-ethyl-1,3-propanediol 2-ethylhexanoate, 2-ethylhexyl hydroxystearate, cholesteryl hydroxystearate, isostearyl lactate, octyldodecyl lactate, citric acid Triethylhexyl acid, acetyl triethyl citrate, acetyl tributyl citrate, diisostearyl malate, diethylhexyl succinate, diisopropyl adipate, adipine Diisobutyl, dioctyl adipate, hexyl adipate tri-2-ethyl, diethyl sebacate, sebacic acid diisopropyl. These can be used individually by 1 type or in combination of 2 or more types.

  When mix | blending liquid ester oil at 25 degreeC, 0.01-20 mass% is preferable, and, as for the compounding quantity in scalp hair cosmetics, More preferably, it is 0.1-10 mass.

  In the scalp hair cosmetic of the present invention, optional components can be blended depending on the purpose of use within a range not impairing the effects of the present invention. Examples of such components include anti-androgenic agents, moisturizers, vitamins, amino acids, purified water, ethanol, celluloses, surfactants other than the above amino acid nonionic surfactants, fats and oils, and polymer resins. , Coloring materials, fragrances, ultraviolet absorbers and the like.

  Examples of surfactants other than the amino acid-based nonionic surfactant include, for example, glycerin fatty acid ester and its alkylene glycol adduct, polyglycerin fatty acid ester of alkylene glycol adduct, propylene glycol fatty acid ester and its alkylene glycol adduct, and sorbitan fatty acid. Ester and its alkylene glycol adduct, sorbitol fatty acid ester and its alkylene glycol adduct, polyalkylene glycol fatty acid ester, sucrose fatty acid ester, polyoxyalkylene alkyl ether, glycerin alkyl ether, polyoxyethylene alkyl phenyl ether, polyoxyethylene hydrogenated castor Oil, lanolin alkylene glycol adduct, polyoxyalkylene modified silicone, polyoxyal Alkylene alkyl co-modified silicone, and alkoxy-modified silicones.

  When blending a fragrance in the scalp hair cosmetic of the present invention, the fragrance used is the same as the fragrance and fragrance composition described in JP-A-2003-1113019. It is suitable to mix | blend so that a fragrance | flavor composition may be 0.00001-50 mass% with respect to the whole quantity of a raw material, More preferably, 0.0001-30 mass% is mix | blended.

  The scalp hair cosmetic of the present invention can be prepared for both the scalp and the hair by mixing the above components, and if necessary, ethanol and water (remainder) based on a conventional method, and is suitable as a hair nurturing agent. Specifically, essence, tonic, hair cream, shampoo, rinse, conditioner, etc. can be used. The dosage form can be prepared in the form of a uniform solution, lotion, gel, cream, aerosol or the like according to a conventional method. In the case of an aerosol, a combustible gas selected from butane, propane, isobutane, liquefied petroleum gas, and dimethyl ether, a compressed gas selected from nitrogen gas, oxygen gas, carbon dioxide gas, and nitrous oxide gas can be blended. Mixtures can also be used.

  The menthol and amino acid-based nonionic surfactants have an excellent transdermal absorption promoting effect of a nourishing hair active ingredient, and the combined use of these has further superior transdermal absorption promoting effects. This is a new finding. Thereby, the scalp hair cosmetic of the present invention is selected from the above (A) cell activator, (B) blood flow improving agent, (C) anti-inflammatory agent, (D) bactericidal agent and (E) local stimulant. It is suitable as a percutaneous absorption enhancer consisting of a mixture containing one or more active hair-growth ingredients, menthol, and less than 0.1 to 3% by mass of an amino acid nonionic surfactant.

  EXAMPLES Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples, unless otherwise specified, “%” in the composition represents mass%.

[Examples 1-8 , Reference Examples 1-14, Comparative Examples 1-5]
A hair growth tonic agent having the composition shown in Tables 1 to 3 was prepared based on a conventional method, and the skin permeability of the hair growth active ingredient in the hair growth tonic agent and the feeling of use (no stickiness) were evaluated. The results are shown in Tables 1-3.

<Skin permeability of hair growth active ingredient>
Skin permeability was measured using a glass Franz diffusion cell shown in FIG. A method for measuring the skin transmittance of an active ingredient using a Franz diffusion cell will be described with reference to FIGS.
Pre-sheared guinea pig (HARTLEY female, female) back peeled skin (5) (5cm x 5cm) into Franz diffusion cell (1) (diffusion effective membrane area approx. 4cm ² ), stratum corneum side as donor (2) The phase was fixed with scissors so that the dermis side became the receptor (3) phase. The receptor (3) side was filled with physiological saline, and then kept at 32 ° C. in the constant temperature layer while stirring with a stirring bar (4). 50 μL of the test sample was added to the donor (2) (stratum corneum side), and physiological saline in the receptor (3) was sampled 24 hours after the addition. The active ingredient for nurturing hair in physiological saline was quantified, and the amount of the effective ingredient (skin permeation amount) in the receptor (3) phase was measured.
The relative value (%) of the permeation amount of each composition was calculated when the permeation amount of the ethanol solution (control) having the blending concentration of each active ingredient was 100%.

It shows below about the quantification method of a nourishing hair active ingredient.
Quantification was performed using high performance liquid chromatography (HPLC).
HPLC measurement condition detector: ultraviolet absorptiometer (measurement wavelength: 210-300 nm)
Column: Inertsil ODS-2 (φ4.6 × 150 mm, manufactured by GL Sciences Inc.)
Column temperature: 40 ° C
Mobile phase: methanol / water mixture When two or more active ingredients are contained, the skin permeability of each is shown.

<Evaluation of feeling of use (no stickiness)>
Ten men who had many hair loss at the time of shampooing and were aware that their hair had become thinly applied 2 mL of hair-growth tonic agent to the entire scalp after shampooing and towel drying, and sensory evaluation was performed. The results are shown according to the following criteria.
Proportion of panelists who judged that there was no standard stickiness and that the usability was good ◎: 8 or more (very good)
○: 6 to 7 people (good)
Δ: 4-5 people (slightly bad)
×: 3 or less (bad)

  Next, Examples prescribed for each dosage form are shown.

[Example 9 ]

[Example 10 ]

[Example 11 ]

[Example 12 ]

[Example 13 ]

[Example 14 ]

[Example 15 ]

[Example 16 ]

[Example 17 ]

[Example 18 ]

[Example 19 ]

[Example 20 ]

[Example 21 ]

[Example 22 ]

The scalp hair cosmetics of Examples 9 to 22 had good skin permeability of the nourishing hair component, had no stickiness, and were excellent in the feeling of use.

  The raw material used in the above example is shown.

Claims (8)

One or more kinds of hair-growth active ingredients selected from the following (A) cell activator, (B) blood flow improving agent, (C) anti-inflammatory agent, (D) bactericidal agent and (E) local stimulant Menthol, 0.1 to 2.5 % by weight of the following amino acid-based nonionic surfactant, and 0.1 to 10% by weight of ester oil which is liquid at 25 ° C., selected from essence, tonic and hair cream Nourishing hair .
Nourishing hair active ingredients:
(A) Cell activator: pentadecanoic acid glyceride, pantothenyl alcohol, pantothenyl ethyl ether, adenosine (B) blood flow improving agent: carpronium chloride, tocopherol acetate, assembly extract, nicotinamide (C) anti-inflammatory agent: β- Glycyrrhetinic acid, glycyrrhetinic acid stearyl, glycyrrhizic acid, ammonium glycyrrhizinate, trisodium glycyrrhizinate, dipotassium glycyrrhizinate, methyl glycyrrhizinate (D) fungicide: isopropylmethylphenol, salicylic acid, hinokitiol, zinc pyrithione, piroctone olamine (E) topical Stimulants: benzyl nicotinate and nonyl acid vanillylamide amino acid nonionic surfactant:
Lauroylglutamate dihexyldecyl, stearoylglutamate dioctyldodecyl, lauroylglutamate dioctyldecyldecyl, lauroylglutamate polyoxyethyleneoctyldodecylether diester, lauroylglutamate polyoxyethylenestearyletherdiester, myristoylmethylaminohexyloxydecylate pyrostearate one or more members selected from castor Abura及 beauty pyroglutamic acid glyceryl oleate
Ester oil in liquid form at 25 ° C:
Propylene glycol dicaprate, neopentyl glycol dicaprate, pentaerythritol tetra2-ethylhexanoate, propylene glycol monocaprylate, propylene glycol dicaprylate, trimethylolpropane tri-2-ethylhexanoate, glyceryl tri-2-ethylhexanoate, 2 -2-butyl-2-ethyl-1,3-propanediol ethylhexanoate, 2-ethylhexyl hydroxystearate, cholesteryl hydroxystearate, isostearyl lactate, octyldodecyl lactate, triethylhexyl citrate, acetyltriethyl citrate, citrate Acetyl tributyl, diisostearyl malate, diethylhexyl succinate, diisopropyl adipate, diisobutyl adipate, diocty adipate , Hexyl adipate tri-2-ethyl, one or more compounds selected from diethyl sebacate and diisopropyl sebacate Nourishing hair active ingredients
(A) Cell activating agent: pantothenyl alcohol, pantothenyl ethyl ether, adenosine (B) blood flow improving agent: carpronium chloride, nicotinamide (C) anti-inflammatory agent: β-glycyrrhetinic acid, stearyl glycyrrhetinate, glycyrrhizic acid, Ammonium glycyrrhizinate, trisodium glycyrrhizinate, dipotassium glycyrrhizinate, methyl glycyrrhizinate (D) fungicide: isopropylmethylphenol, salicylic acid, hinokitiol, zinc pyrithione, piroctone olamine (E) local stimulant: selected from nonylic acid vanillylamide The hair nurturing agent according to claim 1. The hair nurturing agent according to claim 1 or 2, wherein the amount of menthol is 0.01 to 2.0 mass%. Furthermore, the hair nourishing agent of any one of Claims 1-3 which contains a polyhydric alcohol 0.1-3 mass%. The polyhydric alcohol is one or more selected from polyethylene glycol, propylene glycol, dipropylene glycol, glycerin, ethylene glycol, diethylene glycol, triethylene glycol, pentanediol, isoprene glycol, hexanediol and 1,3-butylene glycol. The hair nurturing agent according to claim 4. (A) Pentadecanoic acid glyceride, pantothenyl alcohol, pantothenyl ethyl ether, adenosine, biotin, placenta extract, mononitroguaiacol, (B) nicotinamide, tocopherol acetate, carpronium chloride, assembly extract, nicotinamide, minoxidil, cephalanthin , Carrot extract, (C) β-glycyrrhetinic acid, dipotassium glycyrrhizinate, ammonium glycyrrhizinate, (D) isopropylmethylphenol, hinokitiol, piroctone olamine, zinc pyrithione, salicylic acid, benzalkonium chloride, propolis and (E) nicotinic acid One or more active hair-growth ingredients selected from benzyl,
With menthol,
Lauroylglutamate dihexyldecyl, lauroylglutamate dioctyldodecyl, stearoylglutamate dioctyldodecyl, pyroglutamate oleic acid glyceryl, lauroylglutamate POE (2) octyldodecyl ether diester, pyroglutamate isostearic acid POE (30) hydrogenated castoramic acid POE (30) 40) hardened castor oil, peak b glutamic acid isostearate POE (50) hardened castor oil, lauroyl glutamic acid POE (5) octyl dodecyl ether diester, lauroylglutamic acid POE (2) stearyl ether diester, lauroylglutamic acid POE (5) stearyl ether diester, And hexyldecyl myristoylmethylaminopropionate Amino acid-based nonionic surfactant one selected et or more and 0.1 to 2.5 wt%,
One or more polyhydric alcohols selected from polyethylene glycol, propylene glycol, glycerin, 1,3-butylene glycol, isoprene glycol and pentanediol;
Propylene glycol monocaprylate, 2-ethylhexyl hydroxystearate, octyldodecyl lactate, triethylhexyl citrate, acetyltriethyl citrate, pentaerythritol tetra-2-ethylhexanoate, diisopropyl adipate, diethyl sebacate, diisostearyl malate, hydroxystearic acid 2-ethylhexyl, containing the neopentyl glycol dicaprate, liquid ester oil one at 25 ° C. selected from propylene glycol dicaprate and glyceryl tri-2-ethylhexanoate or 2 or more, essences, tonics and Hair nourishing agent selected from hair creams . (A) pantothenyl alcohol, adenosine, (B) nicotinic acid amide, (C) β-glycyrrhetinic acid and (D) one or more kinds of nourishing hair active ingredients selected from isopropylmethylphenol,
With menthol,
Amino acid nonionic surfactant 1 selected from lauroyl glutamic acid POE (2) stearyl ether diester, lauroyl glutamic acid POE (5) stearyl ether diester, hexyldecyl myristoylmethylaminopropionate and isostearic acid pyrostearate POE (30) hydrogenated castor oil 0.1 to 2.5 mass% of seeds or two or more kinds,
One or more polyhydric alcohols selected from polyethylene glycol, propylene glycol, glycerin and 1,3-butylene glycol;
A hair nurturing agent selected from essence, tonic and hair cream, containing at least one ester oil that is liquid at 25 ° C selected from propylene glycol monocaprylate, 2-ethylhexyl hydroxystearate, and octyldodecyl lactate . One or more kinds of hair-growth active ingredients selected from the following (A) cell activator, (B) blood flow improving agent, (C) anti-inflammatory agent, (D) bactericidal agent and (E) local stimulant Menthol, 0.1 to 2.5% by mass of the following amino acid nonionic surfactant , and a polyhydric alcohol selected from polyethylene glycol, propylene glycol, glycerin, 1,3-butylene glycol, isoprene glycol and pentanediol Or the above-mentioned nurturing containing 2 or more types and one or more ester oils liquid at 25 ° C. selected from propylene glycol monocaprylate, 2-ethylhexyl hydroxystearate, octyldodecyl lactate and triethylhexyl citrate Transdermal absorption enhancer of hair active ingredients.
(A) Cell activator: pentadecanoic acid glyceride, pantothenyl alcohol, pantothenyl ethyl ether, adenosine (B) blood flow improving agent: carpronium chloride, tocopherol acetate, assembly extract, nicotinamide (C) anti-inflammatory agent: β- Glycyrrhetinic acid, glycyrrhetinic acid stearyl, glycyrrhizic acid, ammonium glycyrrhizinate, trisodium glycyrrhizinate, dipotassium glycyrrhizinate, methyl glycyrrhizinate (D) fungicide: isopropylmethylphenol, salicylic acid, hinokitiol, zinc pyrithione, piroctone olamine (E) topical Stimulants: benzyl nicotinate and nonyl acid vanillylamide amino acid nonionic surfactant:
Lauroylglutamate dihexyldecyl, stearoylglutamate dioctyldodecyl, lauroylglutamate dioctyldecyldecyl, lauroylglutamate polyoxyethyleneoctyldodecylether diester, lauroylglutamate polyoxyethylenestearyletherdiester, myristoylmethylaminohexyloxydecylate pyrostearate one or more members selected from castor Abura及 beauty pyroglutamic acid glyceryl oleate

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