JP5565016B2 - Composition for improving hypothermia and composition for improving cooling - Google Patents

Description

  The present invention relates to an agent for improving hypothermia caused by, for example, modulation of life rhythm and a composition containing the same.

The body temperature of thermostats such as humans decreases due to, for example, lifestyle rhythms such as not having breakfast, night life, irregular sleeping hours, and inactive physical activity during the day. The decrease in body temperature causes, for example, a decrease in physiological functions such as chills / discomfort, wound infection, delayed wound healing, and decreased immunity, and may result in death due to an extreme decrease in body temperature. Therefore, when the body temperature falls beyond the range determined by the normal activity state of the species, it is necessary to restore the body temperature to an appropriate range, and thus various body temperature raising means have been developed so far. .

  For example, as a means for warming a cold body, blood circulation is promoted by ingestion of blood flow promoting agents such as tocopherol acetate, ginseng, ginger, etc., massage of limbs, etc., and ingestion of warm food and drink. In addition, for the purpose of increasing body temperature by promoting energy metabolism by pungent components, beverages containing capsaicin as an active ingredient have been proposed (Patent Document 1: JP 2000-189121 A). However, although the body surface temperature can be increased with the blood flow promoting agent, the deep body temperature cannot be increased, and the fundamental solution for the decrease in body temperature cannot be achieved. In addition, the intake of warm food and drink is a temporary effect, and there is a problem in terms of sustainability. About capsaicin, it is a pungent component contained in chili pepper, and when adding a large amount of capsaicin, the pungent taste is strongly felt, so the amount to be added is limited. From the above, what has promptly improved hypothermia has been desired.

JP 2000-189121 A

  The present invention has been made in view of the above circumstances, and includes a hypothermia improving agent that quickly improves a hypothermia state, for example, a hypothermia state caused by modulation of life rhythm, and increases a deep body temperature, and the same. It aims at providing the composition for hypothermia improvement, and the composition for cooling property improvement.

  As a result of intensive studies to achieve the above object, the present inventors have found that the quinoa extract has an effect of improving hypothermia, particularly an effect of suppressing a decrease in deep body temperature, and has led to the present invention. Conventionally, it is not known that the quinoa extract has the above-mentioned effect, which is a new finding of the present inventors.

Therefore, the present invention provides the following composition for improving hypothermia and composition for improving cooling .
[1]. 99% by mass or more of a quinoa extract containing an ethanol-containing solvent as an active ingredient, and the intake of the quinoa extract (solid content) is 0.01 to 100 mg / kg for an adult body weight of 1 to 100 mg / kg for hypothermia improvement Composition.
[2]. 99% by mass or more of a quinoa extract containing an ethanol-containing solvent as an active ingredient, and the intake of the quinoa extract (solid content) is 0.01 to 100 mg / kg for an adult body weight of 1 to 100 mg / kg. object.

  ADVANTAGE OF THE INVENTION According to this invention, the hypothermia state, for example, the hypothermia state resulting from the modulation | alteration of a life rhythm can be improved rapidly, and the hypothermia improvement agent and the composition for hypothermia improvement which raise deep body temperature are provided. it can.

It is a schematic diagram which shows the administration method in an Example.

  Hereinafter, the present invention will be described in detail. The hypothermia improving agent of this invention consists of a quinoa extract, and uses a quinoa extract for the hypothermia improvement use. Quinoa is a plant belonging to the genus Rhizoaceae, Rhizopus.

  The quinoa extract is not particularly limited as long as it is an extract from quinoa, and a plant extract obtained by a known extraction method can be used. The extraction part is not particularly limited, and specific parts such as whole plants or rhizome parts, bark parts and fruit parts of various plants can be used, and seeds are particularly preferred. In the case of seeds, they can be threshed, dried, ground and used as a powder. The extraction method is not particularly limited, and a known extraction method such as solvent extraction, steam distillation, or supercritical extraction can be employed. For example, in the case of solvent extraction, quinoa can be obtained raw or after being dried, cut and processed into an appropriate size, immersed in an extraction solvent, and stirred. The extraction may be heated as necessary, the time is appropriately selected, and the extraction pH is not particularly limited unless it is extremely acidic or alkaline. Examples of the solvent used in the extraction method include water; alcohols such as methanol, ethanol, propanol, and butanol; polyhydric alcohols such as propylene glycol and butylene glycol, and the like. These may be used alone or in appropriate combination of two or more. Can be used. As the extraction solvent, an ethanol-containing solvent is preferable. The ethanol-containing solvent may contain alcohol other than the above water and ethanol in addition to ethanol. The ethanol concentration of the ethanol-containing solvent is preferably 90% by mass or more, more preferably 95% by mass or more, and further preferably 99% by mass or more. Such an ethanol-containing solvent extract of 95% by mass or more shows a remarkable hypothermic improvement effect. In addition, you may filter after extraction and may perform well-known refinement | purification suitably. The shape of the Keanu extract is not particularly limited, and examples thereof include those obtained by the above treatment as they are, such as liquids such as dilutions and concentrates, pastes, and dry powders by freeze drying.

  Hypothermia is difficult to specify in the numerical range because of individual differences, but generally 36.5 to 37.5 ° C for rats and the like, and 35.0 to less than 36.0 ° C for humans .

  The dose of the quinoa extract (solid content) is appropriately selected depending on the type, age and degree of hypothermia, but is usually 0.01 to 100 mg / kg, preferably 0.1 to 0.1 kg of adult body weight. The range is 50 mg / kg.

  The hypothermia-improving agent of the present invention is used for animals having a constant deep body temperature (constant temperature animals), and particularly mammals (eg, humans, rats, mice, guinea pigs, dogs, cats, monkeys, horses, cows, sheep, goats). , Rabbits, etc.).

  The hypothermia improving agent of the present invention may be used in combination with other hypothermia improving agents. In addition, it is particularly effective in improving hypothermia caused by the modulation of life rhythm, and particularly exhibits an effect of suppressing deep body temperature decrease. Here, deep body temperature means the temperature of the deep part of the body (for example, rectum, esophagus, heart, brain, etc.), and is usually rectal temperature. For example, in the case of a rat, the deep body temperature can be measured using a capsule for body temperature measurement (23 mm long × 8 mm diameter, PDT-4000, manufactured by MiniMitter) in the abdominal cavity. The measurement in the case of humans can be based on the armpit temperature, oral cavity (sublingual) temperature, and rectal temperature.

  Since quinoa extract has the above effects, low blood pressure, decreased visceral function (constipation / diarrhea), decreased immunity, poor circulation (coldness, stiff shoulders, low back pain, joint pain), sleep disorders, metabolism by taking quinoa extract It can be expected to prevent or improve reduction (obesity), depression, etc.

  The hypothermia improving agent of the present invention can be used as it is, but it can also be used as a hypothermia improving composition containing the same. Moreover, from the above effect of the quinoa extract, it can also be provided as a cooling property improving composition, an obesity suppressing composition, and an immunostimulating composition. Furthermore, it can be set as the product which attached | subjected the indication that it was used for hypothermia improvement, coolness improvement, obesity suppression, and immunostimulation. The content of the quinoa extract (corresponding to the solid content) in the composition is not particularly limited and is appropriately selected according to the above dose (intake amount), 0.005 to 50% by mass, preferably 0.01 to It is appropriately selected within the range of 30% by mass.

  In the composition of the present invention, any commonly used optional component can be blended according to each dosage form. These can be used individually by 1 type or in combination of 2 or more types, The appropriate quantity can be mix | blended.

  Examples of optional ingredients include vitamins, minerals, skin-beautifying ingredients, sweeteners, sour agents, preservatives, fragrances, and pigments.

Vitamins, vitamin _{B 1, B 2, B 6} , B 12, C, A, D, E, K, niacin, folic acid, pantothenic acid, biotin, ubiquinone and derivatives thereof. Among _{these, B 1, B 2, B} 6, B 12, C is preferable. It is preferable that the proper blending amount in the vitamin composition is in accordance with the blending limit amount of each nutrient of the nutritional functional food.

  Examples of minerals include calcium, iron, phosphorus, magnesium, potassium, selenium, and zinc. The optimum blending amount is preferably in accordance with the blending limit amount of nutrients of the nutritional functional food. It is preferable that the optimum content in the mineral composition is in accordance with the nutritional limit of each nutrient-functional food.

  As a beautifying skin component, a component that enhances the moisture retention of the skin or improves the metabolism of the skin can be blended. Examples include hyaluronic acid, elastin, coenzyme Q10, α-lipoic acid, aloe, ceramide, royal jelly, astaxanthin, amino acids, glucosamine, ellagic acid, coenzyme and the like.

  Examples of the sweetener include sucrose, fructose, glucose, fructose glucose liquid sugar, honey, erythritol, sorbitol, xylitol, aspartame, acesulfame potassium, sucralose and the like. Examples of the sour agent include citric acid, malic acid, and lactic acid.

  For example, in the case of solid preparations such as tablets (including chewable tablets, orally disintegrating tablets), granules, capsules, etc., the following excipients, binders, disintegrants, lubricants, etc. may be blended. it can.

  Examples of excipients include cellulose and derivatives thereof, starch and derivatives thereof, saccharides, sugar alcohols, and the like. More specifically, crystalline cellulose, lactose, sucrose, mannitol, erythritol, corn starch, potato starch, hydroxy And propyl starch.

  Examples of the binder include hydroxypropylcellulose, hydroxypropylmethylcellulose, methylcellulose, ethylcellulose, polyvinyl alcohol, polyvinylpyrrolidone, gelatin, dextrin, starch, pregelatinized starch and the like.

  Examples of the disintegrant include carmellose, carmellose calcium, croscarmellose sodium, low-substituted hydroxypropylcellulose, low-substituted carboxymethyl starch sodium, crospovidone and the like.

  Examples of the lubricant include magnesium stearate, calcium stearate, sucrose fatty acid ester, anhydrous silicic acid, light anhydrous silicic acid, sodium stearyl fumarate, talc and the like.

  The production method of the solid preparation is not particularly limited, and the quinoa extract and an optional component are mixed, and the mixture can be compressed by a tableting machine or the like to obtain a tablet. By individually packaging the mixture, Granules can be obtained. Furthermore, the above mixture can be filled into capsules containing gelatin, hydroxypropylmethylcellulose and the like to form capsules.

  For example, in the case of a drink (liquid), a thickening polysaccharide or the like can be blended. Examples of the thickening polysaccharide include gellan gum, carrageenan, pectin, guar gum, locust bean gum, tamarind gum, xanthan gum, curdlan (β-1,3-glucan), hyaluronic acid and the like. These can be used individually by 1 type or in combination of 2 or more types. The liquid can be obtained by mixing the quinoa extract, optional components and water (remainder).

  EXAMPLES Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example.

[Preparation Example: Preparation of quinoa extract]
60 g of quinoa powder (seed derived, manufactured by Dainippon Meiji Sugar Co., Ltd.) was taken, immersed in 600 mL of ethanol (99.5%, manufactured by Wako Pure Chemical Industries, Ltd.), and extracted at room temperature for 5 days. The extract obtained by filtering the residue was concentrated under reduced pressure to obtain 3 g of a dried product (solid content).

[Example 1, Comparative Examples 1 and 2]
A schematic diagram showing the administration method is shown in FIG.
A body temperature measurement capsule (23 mm long × 8 mm diameter, PDT-4000, manufactured by MiniMitter) was implanted in the abdominal cavity of a rat (SD system, male, 5 weeks old; Japan SLC Co., Ltd.) and reared by free intake for 21 days. Body temperature was measured (body temperature at free intake: (1)) (environmental temperature 22 ° C. ± 0.5 ° C., light / dark cycle: light period 12 hours, dark period 12 hours). Thereafter, the standard diet CE-2 (manufactured by Clea Japan Co., Ltd.) was ingested only during the light period, which is the rest period, and the diet intake in the dark period was stopped and reared for 35 days to induce hypothermia (body temperature at the time of diet restriction: (2)). Next, 0.05% by mass of quinoa extract (the above preparation) was added to the standard bait (Example 1), and 0.02% by mass of capsaicin (manufactured by Wako Pure Chemical Industries, Ltd.) was added to the standard bait (comparison). Example 1) As a control, only a standard bait (Comparative Example 2) was ingested for 20 days per day for 20 days (corresponding to 10 mg for quinoa extract and 4 mg for capsaicin) for 45 days. Thereafter, a standard diet was freely ingested for 10 days, and the body temperature was measured (body temperature at the time of ingestion again: (3), measured daily). In addition, it implemented by 3 per group.
The body temperature was measured by using the capsule for measuring body temperature in the abdominal cavity. Moreover, the body temperature at the time of re-free intake: (3) was measured, and the body temperature at the time of diet restriction: (2) was evaluated for the period when the body temperature at the time of free intake: (1) was recovered. The results are shown in Table 1.

  As apparent from Table 1, the group to which the quinoa extract was administered had a short body temperature recovery period, and an effect of promoting recovery from hypothermia was observed.

[Example 2]
A chewable tablet having the following composition was obtained by a conventional method.
Composition Erythritol 85.0% by mass
Quinoa extract 1.0
Potato starch 4.0
Talc 3.5
Magnesium stearate 1.5
Citric acid 5.0
Total 100.0

[Example 3]
A drink having the following composition was obtained by a conventional method.
Composition glucose 1.5 mass%
Fructose 1.5
Quinoa extract 0.01
Sodium chloride 0.03
Vitamin C 0.03
Citric acid 0.01
Malic acid 0.01
Hyaluronic acid 0.01
Fragrance 0.01
Water balance
Total 100.00

Claims (2)

99% by mass or more of a quinoa extract containing an ethanol-containing solvent as an active ingredient, and the intake of the quinoa extract (solid content) is 0.01 to 100 mg / kg for an adult body weight of 1 to 100 mg / kg for hypothermia improvement Composition. 99% by mass or more of a quinoa extract containing an ethanol-containing solvent as an active ingredient, and the intake of the quinoa extract (solid content) is 0.01 to 100 mg / kg for an adult body weight of 1 to 100 mg / kg. object.

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